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[PMID]:29177263
[Au] Autor:Cheki M; Gali H
[Ad] Endereço:Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. mohsencheky@gmail.com.
[Ti] Título:Primary radiation dosimetry of a novel PET radiopharmaceutical Ga-NODAGA-glycine in comparison with Tc-DTPA in renal studies.
[So] Source:Hell J Nucl Med;20(3):241-246, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In this study, we tried to estimate human absorbed dose of Ga-NODAGA-glycine as a new potential positron emission tomography (PET) renal agent based on the biodistribution data reported in healthy rats, and compare our estimation with the available absorbed dose data from technetium-99m-diethylenetriaminepentaacetic acid ( Tc-DTPA). SUBJECTS AND METHODS: The medical internal radiation dose (MIRD) formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for various organs in humans. S factor calculated by Monte-Carlo N-particle (MCNP) simulation and also this factor has been taken from the tables presented in MIRD pamphlet No.11. Hence, two radiation absorbed dose were calculated for organs. RESULTS: Our dose prediction shows that an 185MBq injection of gallium-68-1,4,7-triazacyclononane-1-γ-glutamylglycine-4,7-diacetic acid ( Ga-NODAGA-glycine) in humans might result in an estimated absorbed dose of 0.063mGy in the whole body when S factor calculated by MCNP simulation. The highest absorbed doses are observed in kidneys, lungs, spleen, liver, and red marrow with 3.510, 0.453, 0.335, 0.268, and 0.239mGy, respectively. In addition to, the estimated absorbed dose for total body after injection of 185MBq of Ga-NODAGA-glycine is 0.053mGy when S factor has been taken from MIRD pamphlet No.11. The highest absorbed doses are observed in kidneys, lungs, liver, spleen, and red marrow with 3.110, 0.438, 0.209, 0.203, and 0.203mGy, respectively. Comparison between human absorbed dose estimation for Ga-NODAGA-glycine and Tc-DTPA indicated that the absorbed dose of the most organs after injection of Tc-DTPA is higher than the amount after Ga-NODAGA-glycine. CONCLUSION: The results showed that Ga-NODAGA-glycine delivers lower dose to the patients. Also due to its application in PET (which offers higher sensitivity and spatial resolution compared to planar or SPET), Ga-NODAGA-glycine would be a superior choice than Tc-DTPA for renography and impose less radiation doses to patients.
[Mh] Termos MeSH primário: Absorção de Radiação/fisiologia
Complexos de Coordenação/farmacocinética
Glicina/análogos & derivados
Compostos Heterocíclicos com 1 Anel/farmacocinética
Rim/metabolismo
Modelos Biológicos
Tomografia por Emissão de Pósitrons/métodos
Radiometria/métodos
Pentetato de Tecnécio Tc 99m/farmacocinética
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Glicina/farmacocinética
Seres Humanos
Rim/diagnóstico por imagem
Especificidade de Órgãos/fisiologia
Projetos Piloto
Dose de Radiação
Exposição à Radiação/análise
Compostos Radiofarmacêuticos/farmacocinética
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (68Ga-NODAGA-glycine); 0 (Coordination Complexes); 0 (Heterocyclic Compounds, 1-Ring); 0 (Radiopharmaceuticals); TE7660XO1C (Glycine); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910609


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[PMID]:28982888
[Au] Autor:Morine Y; Enkhbold C; Imura S; Ikemoto T; Iwahashi S; Saito YU; Yamada S; Utsunomiya T; Shimada M
[Ad] Endereço:Department of Surgery, Institute of Biochemical Sciences, Tokushima University Graduate School, Tokushima, Japan ymorine@tokushima-u.ac.jp.
[Ti] Título:Accurate Estimation of Functional Liver Volume Using Gd-EOB-DTPA MRI Compared to MDCT/ Tc-SPECT Fusion Imaging.
[So] Source:Anticancer Res;37(10):5693-5700, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: We assessed the utility of dynamic magnetic resonance imaging (MRI) with gadoxetate-ethoxybenzyl-diethylenetriamine penta-aceticpenta-acetic acid (Gd-EOB-DTPA) (EOB-MRI) for estimating functional liver volume compared to Tc-galactosyl albumin single-photon-emission computed tomography ( Tc-GSA SPECT). PATIENTS AND METHODS: Regional functional liver volume (left lateral, medial, right anterior, right posterior) of 58 hepatectomized patients was assessed using EOB-MRI and Tc-GSA SPECT, and compared to the actual liver volume with MDCT-3D volumetry. RESULTS: Tc-GSA SPECT found a significantly lower functional volume of the left lateral section than the actual volume found by MDCT-3D volumetry (p=0.003) and EOB-MRI (p<0.001). Functional liver volume of right anterior section found with Tc-GSA SPECT was significantly higher than that found by MDCT-3D volumetry (p=0.04), despite no differences in asialoglycoprotein receptor 1 (ASGR1) or ATP-dependent organic anion transporting polypeptide 1 (OATP) expression between the left lateral and right anterior sections. CONCLUSION: Tc-GSA SPECT might underestimate the function of the left lobe and overestimate that of the right lobe. Therefore, EOB-MRI could be better for estimating the true regional functional liver reserve.
[Mh] Termos MeSH primário: Meios de Contraste/administração & dosagem
Gadolínio DTPA/administração & dosagem
Fígado/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Tomografia Computadorizada Multidetectores
Compostos Radiofarmacêuticos/administração & dosagem
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único/métodos
Agregado de Albumina Marcado com Tecnécio Tc 99m/administração & dosagem
Pentetato de Tecnécio Tc 99m/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Receptor de Asialoglicoproteína/análise
Biomarcadores/análise
Biópsia
Feminino
Hepatectomia
Seres Humanos
Imuno-Histoquímica
Fígado/química
Fígado/cirurgia
Masculino
Meia-Idade
Tamanho do Órgão
Transportadores de Ânions Orgânicos/análise
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ASGR1 protein, human); 0 (Asialoglycoprotein Receptor); 0 (Biomarkers); 0 (Contrast Media); 0 (Organic Anion Transporters); 0 (Radiopharmaceuticals); 0 (SLCO1A2 protein, human); 0 (Technetium Tc 99m Aggregated Albumin); 0 (gadolinium ethoxybenzyl DTPA); 0 (technetium Tc 99m DTPA-galactosyl-human serum albumin); K2I13DR72L (Gadolinium DTPA); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28445308
[Au] Autor:Tsai SY; Wang SY; Shiau YC; Yang LH; Wu YW
[Ad] Endereço:aDepartment of Nuclear Medicine, Far Eastern Memorial Hospital, New Taipei City bDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei cDepartment of Neurosurgery, Far Eastern Memorial Hospital, New Taipei City dNational Yang-Ming University School of Medicine, Taipei eDepartment of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
[Ti] Título:Clinical value of radionuclide shuntography by qualitative methods in hydrocephalic adult patients with suspected ventriculoperitoneal shunt malfunction.
[So] Source:Medicine (Baltimore);96(17):e6767, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To determine the clinical value of radionuclide shuntography in the evaluation of adult hydrocephalic patients with suspected ventriculoperitoneal (V-P) shunt malfunction. All adult patients who underwent Tc-99m diethylenetriamine pentaacetic acid shuntographic scans at Far Eastern Memorial Hospital between August 2005 and December 2015 were included. Shuntographic results were visually evaluated in a simple qualitative manner: prompt flow that reached the peritoneum on 30-minute early images and diffuse peritoneal tracer distribution on 2-hour delayed images were interpreted as nonobstructive shunt flow. Partial dysfunction was diagnosed as scintigraphic findings between no obstruction and complete obstruction (where complete malfunction indicated no peritoneal distribution on delayed images). The results were correlated with the clinical outcomes and surgical results within 30 days. Diagnostic sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were also calculated. A total of 93 scans in 69 patients with suspected V-P shunt malfunction were analyzed. Sixty-two scans were interpreted as abnormal, including complete (n = 26, 41.9) distal obstruction, partial (n = 35, 56.5) distal dysfunction, and miscellaneous (n = 1, 1.6, cerebrospinal fluid leak). The Se and Sp were 83.0% and 55.0%, respectively, and PPV, NPV, and accuracy were all 71.0%. Twenty-five patients (28 scans) underwent surgical revision, and the results were highly concordant with the imaging findings (Se, 92.0%; Sp, 100.0%; PPV, 100.0%; NPV, 60.0%; and accuracy, 92.9%). Radionuclide shuntography provides useful information in adult patients with V-P shunt malfunction and could be used to guide further surgical intervention.
[Mh] Termos MeSH primário: Análise de Falha de Equipamento
Hidrocefalia/terapia
Derivação Ventriculoperitoneal/instrumentação
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cintilografia
Compostos Radiofarmacêuticos
Reoperação
Estudos Retrospectivos
Sensibilidade e Especificidade
Pentetato de Tecnécio Tc 99m
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Radiopharmaceuticals); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006767


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[PMID]:28223001
[Au] Autor:Molitoris BA
[Ad] Endereço:Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indiana Center for Biological Microscopy, Rouderbush VA, Indianapolis, IN. Electronic address: bmolitor@iu.edu.
[Ti] Título:Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity?
[So] Source:Am J Kidney Dis;69(5):675-683, 2017 May.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic kidney disease (CKD) is an increasing clinical problem. Although clinical risk factors and biomarkers for the development and progression of CKD have been identified, there is no commercial surveillance technology to definitively diagnose and quantify the severity and progressive loss of glomerular filtration rate (GFR) in CKD. This has limited the study of potential therapies to late stages of CKD when FDA-registerable events are more likely. Because patient outcomes, including the rate of CKD progression, correlate with disease severity and effective therapy may require early intervention, being able to diagnose and stratify patients by their level of decreased kidney function early on is key for translational progress. In addition, renal reserve, defined as the increase in GFR following stimulation, may improve the quantification of GFR based solely on basal levels. Various groups are developing and characterizing optical measurement techniques using new minimally invasive or noninvasive approaches for quantifying basal and stimulated kidney function. This development has the potential to allow widespread individualization of therapy at an earlier disease stage. Therefore, the purposes of this review are to suggest why quantifying stimulated GFR, by activating renal reserve, may be advantageous in patients and to review fluorescent technologies to deliver patient-specific GFR.
[Mh] Termos MeSH primário: Creatinina/metabolismo
Taxa de Filtração Glomerular
Insuficiência Renal Crônica/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Nefropatias Diabéticas/metabolismo
Nefropatias Diabéticas/fisiopatologia
Proteínas na Dieta/metabolismo
Progressão da Doença
Intervenção Médica Precoce
Fluoresceína-5-Isotiocianato/análogos & derivados
Fluoresceínas
Seres Humanos
Inulina/análogos & derivados
Rim/diagnóstico por imagem
Oligossacarídeos
Imagem Óptica
Volume Plasmático
Compostos Radiofarmacêuticos
Insuficiência Renal Crônica/diagnóstico por imagem
Insuficiência Renal Crônica/fisiopatologia
Índice de Gravidade de Doença
Pentetato de Tecnécio Tc 99m
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dietary Proteins); 0 (FITC-inulin); 0 (Fluoresceins); 0 (Oligosaccharides); 0 (Radiopharmaceuticals); 0 (fluorescein-isothiocyanate sinistrin); 9005-80-5 (Inulin); AYI8EX34EU (Creatinine); I223NX31W9 (Fluorescein-5-isothiocyanate); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


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[PMID]:28204544
[Au] Autor:Zanni MV; Toribio M; Wilks MQ; Lu MT; Burdo TH; Walker J; Autissier P; Foldyna B; Stone L; Martin A; Cope F; Abbruzzese B; Brady T; Hoffmann U; Williams KC; El-Fakhri G; Grinspoon SK
[Ad] Endereço:Program in Nutritional Metabolism and.
[Ti] Título:Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals.
[So] Source:J Infect Dis;215(8):1264-1269, 2017 Apr 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background.: The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease. Methods.: We trialed a novel macrophage-specific arterial imaging technique. Results.: We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status. Conclusion.: These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV. Clinical Trials Registration.: NCT02542371.
[Mh] Termos MeSH primário: Aterosclerose/diagnóstico por imagem
Infecções por HIV/complicações
Macrófagos/citologia
Placa Aterosclerótica/diagnóstico por imagem
[Mh] Termos MeSH secundário: Aorta/diagnóstico por imagem
Aterosclerose/etiologia
Estudos de Casos e Controles
Estudos Transversais
Dextranos
Seres Humanos
Lectinas Tipo C/metabolismo
Linfonodos/diagnóstico por imagem
Masculino
Mananas
Lectinas de Ligação a Manose/metabolismo
Meia-Idade
Placa Aterosclerótica/virologia
Compostos Radiofarmacêuticos
Receptores de Superfície Celular/metabolismo
Análise de Regressão
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
Pentetato de Tecnécio Tc 99m/análogos & derivados
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Dextrans); 0 (Lectins, C-Type); 0 (Mannans); 0 (Mannose-Binding Lectins); 0 (Radiopharmaceuticals); 0 (Receptors, Cell Surface); 0 (mannose receptor); 0 (technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix095


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[PMID]:28166156
[Au] Autor:Vamadevan S; Le K; Bui C; Mansberg R
[Ad] Endereço:From the *Department of Nuclear Medicine and PET, Nepean Hospital, Penrith, NSW, Australia; and †Nepean Medical School, University of Sydney, NSW, Australia.
[Ti] Título:Incidental 99mTc-DTPA Uptake in Tarlov Cysts on Radionuclide SPECT/CT Cisternography.
[So] Source:Clin Nucl Med;42(4):287-288, 2017 Apr.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sacral perineural cysts are also known as Tarlov cysts. A 58-year-old man with suspected intracranial hypotension was evaluated with Tc-DTPA radionuclide cisternography. Radionuclide planar and SPECT/CT cisternography revealed Tc-DTPA uptake in sacral lesions. Spine MRI confirmed Tarlov cysts at the S1 and S2 levels.
[Mh] Termos MeSH primário: Mielografia
Compostos Radiofarmacêuticos
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
Cistos de Tarlov/diagnóstico por imagem
Pentetato de Tecnécio Tc 99m
[Mh] Termos MeSH secundário: Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Sacro/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001572


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[PMID]:28154020
[Au] Autor:Haddadin Z; Lee V; Conlin C; Zhang L; Carlston K; Morrell G; Kim D; Hoffman JM; Morton K
[Ad] Endereço:University of Utah School of Medicine, Salt Lake City, Utah.
[Ti] Título:Comparison of Performance of Improved Serum Estimators of Glomerular Filtration Rate (GFR) to Tc-DTPA GFR Methods in Patients with Hepatic Cirrhosis.
[So] Source:J Nucl Med Technol;45(1):42-49, 2017 03.
[Is] ISSN:1535-5675
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glomerular filtration rate (GFR) measurements are critical in patients with hepatic cirrhosis but potentially erroneous when based on serum creatinine. New equations for estimated GFR (eGFR) have shown variable performance in cirrhotics, possibly because of inaccuracies in reference methods for measured GFR (mGFR). The primary objective was to compare the performance of 4 improved eGFR equations with a 1-compartment, 2-sample plasma slope intercept Tc-DTPA mGFR method to determine whether any of the eGFR calculations could replace plasma Tc-DTPA mGFR in patients with cirrhosis. The secondary objective was to test the hypothesis that mGFR using voluntary voided urine collections introduces error compared with plasma-only methods. Fifty-four patients with hepatic cirrhosis underwent mGFR determinations from 2 plasma samples at 1 and 3 h after intravenous administration of 185 MBq of Tc-DTPA. GFR was also generated by a UV/P calculation derived from blood and urine samples. These mGFRs were compared with the eGFRs generated by 4 estimating equations: MDRD (Modified Diet in Renal Disease), CKD-EPI (Chronic Kidney Disease-Epidemiology Collaboration) (serum creatinine [SCr]), CKD-EPI (cystatin [CysC]), and CKD-EPI (CysC+SCr). eGFRs were compared with mGFRs by Pearson correlation, precision, bias, percentage bias, and accuracy (eGFRs varying by <10% [p10], <20% [p20] or <30% [p30] from the corresponding mGFR). All eGFRs showed poorer performance when the UV/P Tc-DTPA mGFR was used as the reference than when the plasma Tc-DTPA mGFR was used. When compared with the plasma Tc-DTPA mGFR method, the performance of all eGFR equations was superior to most published reports. There was a moderately good positive correlation between eGFRs and mGFRs. When compared with plasma Tc-DTPA mGFR, precision of eGFRs was in the range of 14-20 mL/min and showed a negligible bias. Compared with the plasma Tc-DTPA mGFR, CKD-EPI (CysC+SCr) showed the best overall performance and accuracy, at 85.19% (p30), 75.93% (p20), and 42.59% (p10). Estimating equations for measuring eGFR performed better than in most published reports, attributable to use of the plasma Tc-DTPA mGFR method as a reference. CKD-EPI (CysC+SCr) eGFR showed the best overall performance. However, more discriminating methods may be required when accurate GFR measurements are necessary. mGFR measurements using urine collections may introduce error compared with plasma-only methods.
[Mh] Termos MeSH primário: Taxa de Filtração Glomerular
Testes de Função Renal/métodos
Cirrose Hepática/sangue
Cirrose Hepática/fisiopatologia
Pentetato de Tecnécio Tc 99m/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Cirrose Hepática/complicações
Masculino
Meia-Idade
Insuficiência Renal Crônica/complicações
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.2967/jnmt.116.180851


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[PMID]:28081622
[Au] Autor:Zhou Y; Gurioli A; Luo J; Li Z; Zhu J; Li J; Liu Y
[Ad] Endereço:1 Guangdong Key Laboratory of Urology, Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, China .
[Ti] Título:Comparison of Effect of Minimally Invasive Percutaneous Nephrolithotomy on Split Renal Function: Single Tract vs Multiple Tracts.
[So] Source:J Endourol;31(4):361-365, 2017 Apr.
[Is] ISSN:1557-900X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To observe serum creatinine (SCr) and treated side glomerular filtration rate (TGFR) variations in patients with upper urinary tract calculi after minimally invasive percutaneous nephrolithotomy (MPCNL). PATIENTS AND METHODS: A total of 178 patients underwent MPCNL in our institute and they were retrospectively evaluated between May 2014 and February 2016. SCr and TGFR variations were observed with renal scintigraphy using 99mTc-diethylene triamine pentaacetic acid ( Tc-DTPA) preoperatively and after at least 6 months of follow-up (FU). The patients were categorized into two groups according to the number of percutaneous access tracts: group I (single tract, n = 122) and group II (multiple tracts, n = 56). RESULTS: At a mean FU of 7.6 months, SCr dropped from 192.9 ± 151.9/L to 167.6 ± 113.9 µM (13.15% decrease, p = 0.008) and TGFR increased from 29.8 ± 21.2 mL/minute preoperatively to 32.7 ± 22.5 mL/minute postoperatively (9.79% increase, p = 0.022) in group I. Similarly, SCr dropped from 238.5 ± 130.1 to 215.8 ± 128.1µ (9.50% decrease, p = 0.013) and TGFR increased from 29.6 ± 21.4 mL/minute preoperatively to 32.9 ± 25.1 mL/minute postoperatively (11.17% increase, p = 0.014) in group II. No statistically significant difference between two groups according to SCr or TGFR variation was observed (p > 0.05). CONCLUSIONS: Stone clearance resulted in improvement of split kidney function after single tract or multiple tract MPCNL. Single tract or multiple tract MPCNL did not show statistically significant difference in split renal function postoperative recovery.
[Mh] Termos MeSH primário: Creatinina/metabolismo
Taxa de Filtração Glomerular
Cálculos Renais/cirurgia
Rim/cirurgia
Nefrostomia Percutânea/métodos
Complicações Pós-Operatórias/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Rim/diagnóstico por imagem
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Complicações Pós-Operatórias/diagnóstico por imagem
Período Pós-Operatório
Cintilografia
Compostos Radiofarmacêuticos
Estudos Retrospectivos
Pentetato de Tecnécio Tc 99m
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); AYI8EX34EU (Creatinine); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1089/end.2016.0822


  9 / 3203 MEDLINE  
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[PMID]:28060781
[Au] Autor:Wu H; Huang Z; Ji M; Li Y; Zhao R
[Ad] Endereço:From the Departments of *Nuclear Medicine, †Gastroenterology, and ‡Radiology, Children's Hospital of Fudan University, Shanghai, People's Republic of China.
[Ti] Título:Detection of an Infant's Duodenal Atresia by Milk Scan.
[So] Source:Clin Nucl Med;42(2):140-142, 2017 Feb.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Duodenal membranous atresia is a rare congenital disease. Here, we present a case of 6-month-old girl referred to us for repeated vomiting since birth. Milk scan was performed, and the results revealed a typical "double-bubble" sign. In addition, only very little activity was shown in the small intestine even at the end of the scintigraphy. These results led to the diagnosis of duodenal atresia, which was subsequently confirmed by gastroenterography and laparotomy. Our case demonstrated the potential value of milk scan in the diagnosis of this congenital disorder.
[Mh] Termos MeSH primário: Obstrução Duodenal/diagnóstico por imagem
Leite
Cintilografia/métodos
Compostos Radiofarmacêuticos/administração & dosagem
Pentetato de Tecnécio Tc 99m/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Duodeno/diagnóstico por imagem
Esôfago/diagnóstico por imagem
Feminino
Seres Humanos
Lactente
Estômago/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001524


  10 / 3203 MEDLINE  
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[PMID]:27812743
[Au] Autor:Kwatra NS; Meany HJ; Ghelani SJ; Zahavi D; Pandya N; Majd M
[Ad] Endereço:Division of Diagnostic Imaging and Radiology, Children's National Medical Center, 111 Michigan Ave. NW, Washington, DC, 20010, USA.
[Ti] Título:Glomerular hyperfiltration in children with cancer: prevalence and a hypothesis.
[So] Source:Pediatr Radiol;47(2):221-226, 2017 Feb.
[Is] ISSN:1432-1998
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Glomerular hyperfiltration has recently been reported in children with malignancies and has been attributed to increased solute from breakdown of tumor tissues. OBJECTIVE: To evaluate the prevalence of hyperfiltration in the pediatric oncology population and explore its pathophysiological mechanism. MATERIALS AND METHODS: Tc-99 m diethylenetriaminepentaacetic acid (DTPA) glomerular filtration rate (GFR) examinations (437 studies) and medical records of 177 patients <21 years of age diagnosed with a malignancy between January 2005 and October 2013 were retrospectively reviewed. Hyperfiltration was defined as a GFR ≥ 160 ml/min/1.73 m . RESULTS: Seventy-seven (43.5%) patients had hyperfiltration in at least one GFR exam. A significantly higher percentage of patients with central nervous system (CNS) tumors (63.6%) had hyperfiltration when compared to other tumor types (27.3%, P < 0.001). No association was found between hyperfiltration and age, gender, race or bone marrow involvement. There was a significant trend toward decreasing hyperfiltration after the second cycle of chemotherapy (P = 0.006) and a significant increase in subjects with low GFR (<100 ml/min/1.73 m ) with increasing number of cycles of chemotherapy (P = 0.005). CONCLUSION: Glomerular hyperfiltration is common in children with malignancies at diagnosis and during initial cycles of chemotherapy. It is particularly prevalent in patients with central nervous tumors, which are frequently smaller in volume. Therefore, the pathophysiological mechanism of hyperfiltration cannot be explained solely on the basis of large tumor volume and subsequent cell breakdown. We hypothesize that host hypermetabolic state plays an important role in pathophysiology of hyperfiltration.
[Mh] Termos MeSH primário: Taxa de Filtração Glomerular
Nefropatias/fisiopatologia
Neoplasias/fisiopatologia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Neoplasias/tratamento farmacológico
Prevalência
Estudos Retrospectivos
Fatores de Risco
Pentetato de Tecnécio Tc 99m/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (technetium Tc 99m diethylene triamine pentaacetic acid, dimethyl ester); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE
[do] DOI:10.1007/s00247-016-3733-5



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