Base de dados : MEDLINE
Pesquisa : D02.092.831 [Categoria DeCS]
Referências encontradas : 5155 [refinar]
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[PMID]:29247746
[Au] Autor:Sun X; Tang L; Winesett S; Chang W; Cheng SX
[Ad] Endereço:Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China; Department of Pediatrics, University of Florida, Gainesville, FL, USA.
[Ti] Título:Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons.
[So] Source:Life Sci;194:49-58, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Calcium-sensing receptor (CaSR) is expressed on neurons of both submucosal and myenteric plexuses of the enteric nervous system (ENS) and the CaSR agonist R568 inhibited Cl secretion in intestine. The purpose of this study was to localize the primary site of action of R568 in the ENS and to explore how CaSR regulates secretion through the ENS. MATERIALS AND METHODS: Two preparations of rat proximal and distal colon were used. The full-thickness preparation contained both the submucosal and myenteric plexuses, whereas for the "stripped" preparation the myenteric plexus with the muscle layers was removed. Both preparations were mounted onto Ussing chambers and Cl secretory responses were compared by measuring changes in short circuit current (I ). Two tissue-specific CaSR knockouts (i.e., neuron-specific vs. enterocyte-specific) were generated to compare the effect of R568 on expression of c-fos protein in myenteric neurons by immunocytochemistry. KEY FINDINGS: In full-thickness colons, tetrodotoxin (TTX) inhibited I , both in proximal and distal colons. A nearly identical inhibition was produced by R568. However, in stripped preparations, while the effect of TTX on I largely remained, the effect of R568 was nearly completely eliminated. In keeping with this, R568 reduced c-fos protein expression only in myenteric neurons of wild type mice and mutant mice that contained CaSR in neurons (i.e., Cre/Casr mice), but not in myenteric neurons of Cre/Casr mice in which neuronal cell CaSR was eliminated. SIGNIFICANCE: These results indicate that R568 exerts its anti-secretory effects predominantly via CaSR-mediated inhibition of neuronal activity in the myenteric plexus.
[Mh] Termos MeSH primário: Eletrólitos/metabolismo
Plexo Mientérico/efeitos dos fármacos
Neurônios/efeitos dos fármacos
Fenetilaminas/farmacologia
Propilaminas/farmacologia
Proteínas Proto-Oncogênicas c-fos/metabolismo
Receptores de Detecção de Cálcio/metabolismo
Bloqueadores dos Canais de Sódio/farmacologia
Tetrodotoxina/farmacologia
[Mh] Termos MeSH secundário: Animais
Colo/efeitos dos fármacos
Colo/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Plexo Mientérico/citologia
Neurônios/metabolismo
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Electrolytes); 0 (N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine); 0 (Phenethylamines); 0 (Propylamines); 0 (Proto-Oncogene Proteins c-fos); 0 (Receptors, Calcium-Sensing); 0 (Sodium Channel Blockers); 4368-28-9 (Tetrodotoxin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:28449584
[Au] Autor:Alghunaim A; Brink ET; Newby EY; Zhang Newby BM
[Ad] Endereço:Department of Chemical and Biomolecular Engineering, The University of Akron, 200 E. Buchtel Commons, Akron, Ohio 44325-3906.
[Ti] Título:Retention of poly(N-isopropylacrylamide) on 3-aminopropyltriethoxysilane.
[So] Source:Biointerphases;12(2):02C405, 2017 04 27.
[Is] ISSN:1559-4106
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Silane coupling agents are commonly employed to link an organic polymer to an inorganic substrate. One of the widely utilized coupling agents is 3-aminopropyltriethoxy silane (APTES). In this study, the authors investigated the ability of APTES to retain thermo-responsive poly(N-isopropylacrylamide) (pNIPAAm) on hydroxylated surfaces such as glass. For comparison purposes, the authors also evaluated the retention behaviors of (1) polystyrene, which likely has weaker van der Waals interactions and acid-base interactions (contributed by hydrogen-bonding) with APTES, on APTES as well as (2) pNIPAAm on two other silane coupling agents, which have similar structures to APTES, but exhibit less interaction with pNIPAAm. Under our processing conditions, the stronger interactions, particularly hydrogen bonding, between pNIPAAm and APTES were found to contribute substantially to the retention of pNIPAAm on the APTES modified surface, especially on the cured APTES layer when the interpenetration was minimal or nonexistent. On the noncured APTES layer, the formation of an APTES-pNIPAAm interpenetrating network resulted in the retention of thicker pNIPAAm films. As demonstrated by water contact angles [i.e., 7°-15° higher at 40 °C, the temperature above the lower critical solution temperature (LCST) of 32 °C for pNIPAAm, as compared to those at 25 °C] and cell attachment and detachment behaviors (i.e., attached/spread at 37 °C, above LCST; detached at 20 °C, below LCST), the retained pNIPAAm layer (6-15 nm), on both noncured and cured APTES, exhibited thermo-responsive behavior. The results in this study illustrate the simplicity of using the coupling/adhesion promoting ability of APTES to retain pNIPAAm films on hydroxylated substrates, which exhibit faster cell sheet detachment (≤30 min) as compared to pNIPAAm brushes (in hours) prepared using tedious and costly grafting approaches. The use of adhesion promoters to retain pNIPAAm provides an affordable alternative to current thermo-responsive supports for cell sheet engineering and stem cell therapy applications.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Propilaminas/química
Silanos/química
[Mh] Termos MeSH secundário: Adsorção
Solventes/química
Propriedades de Superfície
Temperatura Ambiente
Termodinâmica
Água/química
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Propylamines); 0 (Silanes); 0 (Solvents); 059QF0KO0R (Water); 25189-55-3 (poly-N-isopropylacrylamide); L8S6UBW552 (amino-propyl-triethoxysilane)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1116/1.4982248


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[PMID]:28470825
[Au] Autor:Börner T; Rämisch S; Bartsch S; Vogel A; Adlercreutz P; Grey C
[Ad] Endereço:Department of Chemistry and Biotechnology, Institute of Materials Science, Nestlé Research Center, Route du Jorat 57, 1000, Lausanne 26, Switzerland.
[Ti] Título:Three in One: Temperature, Solvent and Catalytic Stability by Engineering the Cofactor-Binding Element of Amine Transaminase.
[So] Source:Chembiochem;18(15):1482-1486, 2017 08 04.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Amine transaminase (ATA) catalyse enantioselectively the direct amination of ketones, but insufficient stability during catalysis limits their industrial applicability. Recently, we revealed that ATAs suffer from substrate-induced inactivation mechanism involving dissociation of the enzyme-cofactor intermediate. Here, we report on engineering the cofactor-ring-binding element, which also shapes the active-site entrance. Only two point mutations in this motif improved temperature and catalytic stability in both biphasic media and organic solvent. Thermodynamic analysis revealed a higher melting point for the enzyme-cofactor intermediate. The high cofactor affinity eliminates the need for pyridoxal 5'-phosphate supply, thus making large-scale reactions more cost effective. This is the first report on stabilising a tetrameric ATA by mutating a single structural element. As this structural "hotspot" is a common feature of other transaminases it could serve as a general engineering target.
[Mh] Termos MeSH primário: Transaminases/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Dimetil Sulfóxido/química
Estabilidade Enzimática
Propilaminas/química
Engenharia de Proteínas
Estrutura Quaternária de Proteína
Fosfato de Piridoxal/química
Piridoxamina/análogos & derivados
Piridoxamina/química
Solventes/química
Temperatura Ambiente
Temperatura de Transição
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Propylamines); 0 (Solvents); 059QF0KO0R (Water); 5V5IOJ8338 (Pyridoxal Phosphate); 6466NM3W93 (Pyridoxamine); EC 2.6.1.- (Transaminases); P8W26T4MTD (2-propylamine); QWW7V29814 (pyridoxamine phosphate); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700236


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[PMID]:28985483
[Au] Autor:Brigante TAV; Miranda LFC; de Souza ID; Acquaro Junior VR; Queiroz MEC
[Ad] Endereço:School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, Brazil.
[Ti] Título:Pipette tip dummy molecularly imprinted solid-phase extraction of Bisphenol A from urine samples and analysis by gas chromatography coupled to mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1067:25-33, 2017 Nov 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Molecularly imprinted polymers (MIPs) were synthesized and used as sorbent for Bisphenol A (BPA) pipette tip solid-phase microextraction from urine samples and BPA analysis by gas chromatography coupled to mass spectrometry (GC-MS). The MIPs were synthesized by the sol-gel methodology. Aminopropyltriethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) were used as functional monomer and cross-linking reagent, respectively. BPA and tetrabromobisphenol A (TBBPA) were evaluated as template during MIP synthesis. The BPA-based MIP displayed slightly higher extraction efficiency than the TBBPA-based dummy molecularly imprinted polymer (DMIP), but the TBBPA-based DMIP was selected as sorbent to minimize interference from leaked template. Comparison of the TBBPA-based DMIP, BPA-based MIP, and non-imprinted polymer (NIP) extraction efficiencies attested that the TBBPA-based DMIP was selective. The synthesized polymers were characterized by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared spectroscopy (FTIR). The TBBPA-based DMIP was reused for over 100 times, which confirmed its robustness. The developed method was linear from 50 to 500ngmL . Precision values had coefficient of variation (CV) ranging from 4 to 14%. The accuracy relative standard deviation values (RSD) varied from -13.6 to 12.3%.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/urina
Cromatografia Gasosa-Espectrometria de Massas/métodos
Impressão Molecular/métodos
Fenóis/urina
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Limite de Detecção
Modelos Lineares
Bifenil Polibromatos/química
Propilaminas/química
Reprodutibilidade dos Testes
Silanos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Phenols); 0 (Polybrominated Biphenyls); 0 (Propylamines); 0 (Silanes); FQI02RFC3A (tetrabromobisphenol A); L8S6UBW552 (amino-propyl-triethoxysilane); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28815595
[Au] Autor:Brindley RL; Bauer MB; Hartley ND; Horning KJ; Currie KPM
[Ad] Endereço:Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
[Ti] Título:Sigma-1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors.
[So] Source:J Neurochem;143(2):171-182, 2017 Oct.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adrenal chromaffin cells (ACCs) are the neuroendocrine arm of the sympathetic nervous system and key mediators of the physiological stress response. Acetylcholine (ACh) released from preganglionic splanchnic nerves activates nicotinic acetylcholine receptors (nAChRs) on chromaffin cells causing membrane depolarization, opening voltage-gated Ca channels (VGCC), and exocytosis of catecholamines and neuropeptides. The serotonin transporter is expressed in ACCs and interacts with 5-HT receptors to control secretion. In addition to blocking the serotonin transporter, some selective serotonin reuptake inhibitors (SSRIs) are also agonists at sigma-1 receptors which function as intracellular chaperone proteins and can translocate to the plasma membrane to modulate ion channels. Therefore, we investigated whether SSRIs and other sigma-1 receptor ligands can modulate stimulus-secretion coupling in ACCs. Escitalopram and fluvoxamine (100 nM to 1 µM) reversibly inhibited nAChR currents. The sigma-1 receptor antagonists NE-100 and BD-1047 also blocked nAChR currents (≈ 50% block at 100 nM) as did PRE-084, a sigma-1 receptor agonist. Block of nAChR currents by fluvoxamine and NE-100 was not additive suggesting a common site of action. VGCC currents were unaffected by the drugs. Neither the increase in cytosolic [Ca ] nor the resulting catecholamine secretion evoked by direct membrane depolarization to bypass nAChRs was altered by fluvoxamine or NE-100. However, both Ca entry and catecholamine secretion evoked by the cholinergic agonist carbachol were significantly reduced by fluvoxamine or NE-100. Together, our data suggest that sigma-1 receptors do not acutely regulate catecholamine secretion. Rather, SSRIs and other sigma-1 receptor ligands inhibit secretion evoked by cholinergic stimulation because of direct block of Ca entry via nAChRs.
[Mh] Termos MeSH primário: Medula Suprarrenal/secreção
Catecolaminas/secreção
Células Cromafins/secreção
Antagonistas Nicotínicos/farmacologia
Receptores Nicotínicos/fisiologia
Receptores sigma/fisiologia
[Mh] Termos MeSH secundário: Medula Suprarrenal/citologia
Medula Suprarrenal/efeitos dos fármacos
Animais
Anisóis/farmacologia
Catecolaminas/antagonistas & inibidores
Bovinos
Células Cultivadas
Células Cromafins/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ligantes
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Propilaminas/farmacologia
Receptores sigma/agonistas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Catecholamines); 0 (Ligands); 0 (Nicotinic Antagonists); 0 (Propylamines); 0 (Receptors, Nicotinic); 0 (Receptors, sigma); 0 (sigma-1 receptor); 149409-57-4 (N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14149


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[PMID]:28721039
[Au] Autor:Bao Z; Sun J; Zhao X; Li Z; Cui S; Meng Q; Zhang Y; Wang T; Jiang Y
[Ad] Endereço:Department of Gastrointestinal Surgery, Lianyungang First People's Hospital, Affiliated Hospital of the Clinical Medical School of Nanjing Medical University, Lianyungang.
[Ti] Título:Top-down nanofabrication of silicon nanoribbon field effect transistor (Si-NR FET) for carcinoembryonic antigen detection.
[So] Source:Int J Nanomedicine;12:4623-4631, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top-down approach is proposed and implemented to fulfill a novel silicon nano-ribbon FET, which acts as biomarker sensor for future clinical application. Compared with the bottom-up approach, a top-down fabrication approach can confine width and length of the silicon FET precisely to control its electrical properties. The silicon nanoribbon (Si-NR) transistor is fabricated on a Silicon-on-Insulator (SOI) substrate by a top-down approach with complementary metal oxide semiconductor (CMOS)-compatible technology. After the preparation, the surface of Si-NR is functionalized with 3-aminopropyltriethoxysilane (APTES). Glutaraldehyde is utilized to bind the amino terminals of APTES and antibody on the surface. Finally, a microfluidic channel is integrated on the top of the device, acting as a flowing channel for the carcinoembryonic antigen (CEA) solution. The Si-NR FET is 120 nm in width and 25 nm in height, with ambipolar electrical characteristics. A logarithmic relationship between the changing ratio of the current and the CEA concentration is measured in the range of 0.1-100 ng/mL. The sensitivity of detection is measured as 10 pg/mL. The top-down fabricated biochip shows feasibility in direct detecting of CEA with the benefits of real-time, low cost, and high sensitivity as a promising biosensor for tumor early diagnosis.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Antígeno Carcinoembrionário/análise
Nanotecnologia/métodos
Nanotubos de Carbono/química
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Desenho de Equipamento
Seres Humanos
Dispositivos Lab-On-A-Chip
Propilaminas/química
Sensibilidade e Especificidade
Silanos/química
Silício/química
Transistores Eletrônicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Carcinoembryonic Antigen); 0 (Nanotubes, Carbon); 0 (Propylamines); 0 (Silanes); L8S6UBW552 (amino-propyl-triethoxysilane); Z4152N8IUI (Silicon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S135985


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[PMID]:28652004
[Au] Autor:Speybrouck D; Doublet C; Cardinael P; Fiol-Petit C; Corens D
[Ad] Endereço:Analytical Sciences - Discovery Sciences, Janssen Research & Development, a Division of Janssen-Cilag, Campus de Maigremont, CS10615, F-27106 Val de Reuil Cedex, France. Electronic address: dspeybro@its.jnj.com.
[Ti] Título:The effect of high concentration additive on chiral separations in supercritical fluid chromatography.
[So] Source:J Chromatogr A;1510:89-99, 2017 Aug 11.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Supercritical Fluid Chromatography is frequently used to efficiently handle separations of enantiomers. The separation of basic analytes usually requires the addition of a basic additive in the mobile phase to improve the peak shape or even to elute the compounds. The effect of increasing the concentration of 2-propylamine as additive on the elution of a series of basic compounds on a Chiralpak-AD stationary phase was studied. In this study, unusual additive concentrations ranging from 0.3% to 10% of 2-propylamine 2-propylaminein the modifier were explored and the effect on retention, peak shape, selectivity and resolution was evaluated. The addition of a large quantity of additive allowed to drastically improve the selectivity and the resolution, and even enantiomers elution order reversal was observed by changing the concentration of basic additive. The role of the ratio additive/modifier appeared a key to tune the enantioselectivity. Finally, the impact of these drastic conditions on the column material was evaluated.
[Mh] Termos MeSH primário: Amilose/análogos & derivados
Cromatografia com Fluido Supercrítico/métodos
Fenilcarbamatos/química
Propilaminas/química
[Mh] Termos MeSH secundário: Amilose/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenylcarbamates); 0 (Propylamines); 138361-09-8 (Chiralpak AD); 9005-82-7 (Amylose); P8W26T4MTD (2-propylamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28333055
[Au] Autor:Li XS; Fan YH; Zhang SW; Qi SH
[Ad] Endereço:State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China E-mail: shihuaqi@cug.edu.cn.
[Ti] Título:Enhanced adsorption removal of anionic dyes via a facile preparation of amino-functionalized magnetic silica.
[So] Source:Water Sci Technol;75(5-6):1399-1409, 2017 03.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel amino-functionalized magnetic silica (Fe O @SiO -NH ) was easily prepared via a one-step method integrating the immobilization of 3-aminopropyltriethoxysilane with a sol-gel process of tetraethyl orthosilicate into a single process. This showed significant improvement in the adsorption capacity of anionic dyes. The product (Fe O @SiO -NH ) was characterized with scanning electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectrometry, zeta potential and vibrating sample magnetometry. The adsorption performance of Fe O @SiO -NH was then tested by removing acid orange 10 (AO10) and reactive black 5 (RB5) from the aqueous solutions under various experimental conditions including initial solution pH, initial dye concentrations, reaction time and temperature. The results indicated that the maximum adsorption capacity of AO10 and RB5 on Fe O @SiO -NH was 621.9 and 919.1 mg g at pH 2, respectively. The sorption isotherms fit the Langmuir model nicely. Similarly, the sorption kinetic data were better fitted into the pseudo-second order kinetic model than the pseudo-first order model. In addition, the thermodynamic data demonstrated that the adsorption process was endothermic, spontaneous and physical. Furthermore, Fe O @SiO -NH could be easily separated from aqueous solutions by an external magnetic field, and the preparation was reproducible.
[Mh] Termos MeSH primário: Corantes/isolamento & purificação
Fenômenos Magnéticos
Propilaminas/química
Silanos/química
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Adsorção
Ânions/isolamento & purificação
Compostos Azo/isolamento & purificação
Concentração de Íons de Hidrogênio
Cinética
Microscopia Eletrônica de Varredura
Naftalenossulfonatos/isolamento & purificação
Reprodutibilidade dos Testes
Soluções
Espectrometria por Raios X
Espectroscopia de Infravermelho com Transformada de Fourier
Eletricidade Estática
Temperatura Ambiente
Termodinâmica
Poluentes Químicos da Água/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anions); 0 (Azo Compounds); 0 (Coloring Agents); 0 (Naphthalenesulfonates); 0 (Propylamines); 0 (Silanes); 0 (Solutions); 0 (Water Pollutants, Chemical); 1Q6EJU80RN (Orange G); 7631-86-9 (Silicon Dioxide); L8S6UBW552 (amino-propyl-triethoxysilane); O0HDY58362 (Remazol black B)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2017.009


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[PMID]:28299545
[Au] Autor:Mu T; Zhao J; Guan Y; Tian J; Yang M; Guo C; Xing J
[Ad] Endereço:Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
[Ti] Título:Desulfurization with Thialkalivibrio versutus immobilized on magnetic nanoparticles modified with 3-aminopropyltriethoxysilane.
[So] Source:Biotechnol Lett;39(6):865-871, 2017 Jun.
[Is] ISSN:1573-6776
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Thialkalivibrio versutus D301 cells were immobilized on Fe O nanoparticles (NPs) synthesized by an improved chemical coprecipitation method and modified with 3-aminopropyltriethoxysilane (APTES), then the immobilized cells were used in sulfur oxidation. RESULTS: The prepared Fe O -APTES NPs had a narrow size distribution (10 ± 2 nm) and were superparamagnetic, with a saturation magnetization of 60.69 emu/g. Immobilized cells had a saturation magnetization of 34.95 emu/g and retained superparamagnetism. The optimum conditions for cell immobilization were obtained at pH 9.5 and 1 M Na . The immobilization capacity of Fe O -APTES NPs was 7.15 g DCW/g-NPs that was 2.3-fold higher than that of Fe O NPs. The desulfurization efficiency of the immobilized cells was close to 100%, having the same sulfur oxidation capacity as free cells. Further, the immobilized cells could be reused at least eight times, retaining more than 85% of their desulfurization efficiency. CONCLUSION: Immobilization of cells with the modified magnetic NPs efficiently increased cell controllability, have no effect on their desulfurization activity and could be effectively used in large-scale industrial applications.
[Mh] Termos MeSH primário: Células Imobilizadas/metabolismo
Ectothiorhodospiraceae/metabolismo
Nanopartículas de Magnetita/química
Nanopartículas de Magnetita/microbiologia
Propilaminas/química
Silanos/química
Enxofre/metabolismo
[Mh] Termos MeSH secundário: Reatores Biológicos/microbiologia
Reutilização de Equipamento
Oxirredução
Tamanho da Partícula
Enxofre/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Magnetite Nanoparticles); 0 (Propylamines); 0 (Silanes); 70FD1KFU70 (Sulfur); L8S6UBW552 (amino-propyl-triethoxysilane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1007/s10529-017-2317-2


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[PMID]:28235747
[Au] Autor:Arabi M; Ghaedi M; Ostovan A
[Ad] Endereço:Chemistry Department, Yasouj University, Yasouj, 75914-35, Iran.
[Ti] Título:Synthesis and application of in-situ molecularly imprinted silica monolithic in pipette-tip solid-phase microextraction for the separation and determination of gallic acid in orange juice samples.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1048:102-110, 2017 Mar 24.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A novel strategy was presented for the synthesis and application of functionalized silica monolithic as artificial receptor of gallic acid at micro-pipette tip. A sol-gel process was used to prepare the sorbent. In this in-situ polymerization reaction, tetraethyl orthosilicate (TEOS), 3-aminopropyl trimethoxysilane (APTMS), gallic acid and thiourea were used, respectively, as cross-linker, functionalized monomer, template and precursor to make crack-free and non-fragile structure. Such durable and inexpensive in-situ monolithic was successfully employed as useful tool for highly efficient extraction of gallic acid from orange juice samples. The effective parameters in extraction recovery were investigated and optimum conditions were obtained using experimental design methodology. Applying HPLC-UV for separation quantification at optimal conditions, the gallic acid was efficiently extracted without significant matrix interference. Good linearity for gallic acid in the range of 0.02-5.0mgL with correlation coefficients of R >0.999 revealed well applicability of the method for trace analysis.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Sucos de Frutas e Vegetais/análise
Ácido Gálico/isolamento & purificação
Impressão Molecular/métodos
Dióxido de Silício/química
Microextração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Citrus sinensis/química
Análise de Alimentos/métodos
Ácido Gálico/análise
Limite de Detecção
Polimerização
Propilaminas/química
Silanos/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Propylamines); 0 (Silanes); 13822-56-5 (3-aminopropyltrimethoxysilane); 42064KRE49 (tetraethoxysilane); 632XD903SP (Gallic Acid); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE



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