Base de dados : MEDLINE
Pesquisa : D02.092.877.883 [Categoria DeCS]
Referências encontradas : 158 [refinar]
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  1 / 158 MEDLINE  
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[PMID]:27432339
[Au] Autor:Sullivan MR; Sokkalingam P; Nguyen T; Donahue JP; Gibb BC
[Ad] Endereço:Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA.
[Ti] Título:Binding of carboxylate and trimethylammonium salts to octa-acid and TEMOA deep-cavity cavitands.
[So] Source:J Comput Aided Mol Des;31(1):21-28, 2017 Jan.
[Is] ISSN:1573-4951
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In participation of the fifth statistical assessment of modeling of proteins and ligands (SAMPL5), the strength of association of six guests (3-8) to two hosts (1 and 2) were measured by H NMR and ITC. Each host possessed a unique and well-defined binding pocket, whilst the wide array of amphiphilic guests possessed binding moieties that included: a terminal alkyne, nitro-arene, alkyl halide and cyano-arene groups. Solubilizing head groups for the guests included both positively charged trimethylammonium and negatively charged carboxylate functionality. Measured association constants (K ) covered five orders of magnitude, ranging from 56 M for guest 6 binding with host 2 up to 7.43 × 10 M for guest 6 binding to host 1.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/química
Compostos Macrocíclicos/química
Proteínas/química
Compostos de Trimetil Amônio/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Desenho de Drogas
Ligantes
Estrutura Molecular
Ligação Proteica
Relação Estrutura-Atividade
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Ligands); 0 (Macrocyclic Compounds); 0 (Proteins); 0 (Trimethyl Ammonium Compounds)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1007/s10822-016-9925-0


  2 / 158 MEDLINE  
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[PMID]:27586274
[Au] Autor:Hee Kim Y; Kim KY; Jun do Y; Kim JS; Kim YH
[Ad] Endereço:Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea; Daegu Science High School, Daegu, 41566, South Korea.
[Ti] Título:Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells.
[So] Source:Biochem Biophys Res Commun;478(4):1609-16, 2016 09 30.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Treatment of Jurkat T cells with the dynamin inhibitor, myristyl trimethyl ammonium bromides (MiTMAB) caused cytokinesis impairment and apoptotic DNA fragmentation along with down-regulation of anti-apoptotic BAG3 and Mcl-1 levels, Bak activation, mitochondrial membrane potential (Δψm) loss, activation of caspase-9 and -3, and PARP cleavage, without accompanying necrosis. Bcl-xL overexpression completely abrogated these MiTMAB-induced mitochondrial damage and resultant caspase cascade activation, except for impaired cytokinesis and down-regulated BAG3 and Mcl-1 levels. Additionally, autophagic responses including Akt-mTOR pathway inhibition, formation of acridine orange-stainable acidic vesicular organelles, LC3-I/II conversion, and p62/SQSTM1 down-regulation were detected regardless of Bcl-xL overexpression. The autophagy inhibitors 3-methyladenine and LY294002 enhanced MiTMAB-induced apoptotic sub-G1 peak, BAG3 and Mcl-1 down-regulation, Bak activation, Δψm loss, and caspase activation. These results indicate that MiTMAB-caused cytokinesis failure leads to concomitant induction of apoptosis and cytoprotective autophagy, and suggest that inhibition of autophagy is a promising strategy to augment antitumor activity of MiTMAB.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Dinaminas/antagonistas & inibidores
Mitocôndrias/metabolismo
Compostos de Trimetil Amônio/farmacologia
Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo
[Mh] Termos MeSH secundário: Adenina/análogos & derivados
Adenina/farmacologia
Anexina A5/metabolismo
Caspases/metabolismo
Ciclo Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Cromonas/farmacologia
Fragmentação do DNA/efeitos dos fármacos
Dinaminas/metabolismo
Citometria de Fluxo
Fluoresceína-5-Isotiocianato/metabolismo
Seres Humanos
Células Jurkat
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Morfolinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Annexin A5); 0 (Chromones); 0 (Morpholines); 0 (Trimethyl Ammonium Compounds); 0 (bcl-2 Homologous Antagonist-Killer Protein); 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one); 5142-23-4 (3-methyladenine); EC 3.4.22.- (Caspases); EC 3.6.5.5 (Dynamins); I223NX31W9 (Fluorescein-5-isothiocyanate); JAC85A2161 (Adenine); Y3IR7RCT6J (tetradecyltrimethylammonium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171127
[Lr] Data última revisão:
171127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE


  3 / 158 MEDLINE  
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[PMID]:27581491
[Au] Autor:Mohd Noh MA; Khalid K; Ariffin A; Khan MN
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Malaya.
[Ti] Título:Kinetics and Mechanism of Cationic Flexible Nanoparticles (CFN) - Catalyzed Piperidinolysis of Anionic Phenyl Salicylate: CFN = TTABr/MX/H2O with MX = NaCl, NaBr; CnH2n+1CO2Na, n = 4, 5, 6 and 7.
[So] Source:J Oleo Sci;65(9):749-58, 2016.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The present study is focused on the effect of the TTABr/MX/H2O-nanoparticles on the rate of piperidinolysis of ionized phenyl salicylate where TTABr represents tetradecyltrimethylammonium bromide and MX = NaCl, NaBr and CnH2n+1CO2Na with n = 4, 5, 6 and 7. Pseudo-first-order rate constant for the piperidinolysis of ionized phenyl salicylate at 35°C and constant concentration [PSa(-)]T = 0.2 mM, [Pip]T = 0.1 M, [NaOH] = 30 mM, [TTABr]T and different [MX] follow an empirical relationship which gives two empirical constant, (X)kcat and K(X/S). The value of relative counterion (X) binding constant, RX(Br) were calculated from the relationship; RX(Br) = (X)kcat/(Br)kcat. The values of RX(Br) for X = C4H9CO2(-), C5H11CO2(-), C6H13CO2(-), and C7H15CO2(-) are increasing with increase in the number of alkyl chain of counterion X.
[Mh] Termos MeSH primário: Bromatos/química
Nanopartículas/química
Salicilatos/química
Cloreto de Sódio/química
Compostos de Sódio/química
Compostos de Trimetil Amônio/química
[Mh] Termos MeSH secundário: Ânions/química
Catálise
Cátions/química
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Bromates); 0 (Cations); 0 (Salicylates); 0 (Sodium Compounds); 0 (Trimethyl Ammonium Compounds); 28A37T47QO (phenyl salicylate); 451W47IQ8X (Sodium Chloride); U54JK6453O (sodium bromate); Y3IR7RCT6J (tetradecyltrimethylammonium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16048


  4 / 158 MEDLINE  
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[PMID]:27442261
[Au] Autor:López GA; Heredia RM; Boeris PS; Lucchesi GI
[Ad] Endereço:Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, Córdoba, Argentina.
[Ti] Título:Content of cardiolipin of the membrane and sensitivity to cationic surfactants in Pseudomonas putida.
[So] Source:J Appl Microbiol;121(4):1004-14, 2016 Oct.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To establish the role of cardiolipin (CL) of the membrane in response to the presence of tetradecyltrimethylammonium in Pseudomonas putida A (ATCC 12633). METHODS AND RESULTS: Two ORFs of Ps. putida A (ATCC 12633), which in Ps. putida KT2440 encode the putative CL synthase genes cls and cls2, were cloned, sequenced and mutated. Only the double mutant lacking cls and cls2 showed a reduction of the CL content, 83% lower than the amount produced by the wild-type. Accompanying this change was a 40% decrease in the content of unsaturated fatty acid. Consequently, the membrane of the mutant was more rigid than the one of the parental strain, as observed using fluorescence polarization techniques. The mutant strain showed reduced viability in the presence of tetradecyltrimethylammonium. The incorporation of exogenous CL into its membrane relieved sensitivity to the cationic detergent. CONCLUSIONS: Pseudomonas Putida cells with low levels of CL die in the presence of tetradecyltrimethylammonium, because they cannot counter the fluidizing effect of the cationic surfactant. SIGNIFICANCE AND IMPACT OF THE STUDY: The modification in the membrane phospholipids composition allows knowing the adaptation strategy of Ps. putida when these bacteria are exposed to cationic surfactant.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Pseudomonas putida/efeitos dos fármacos
Tensoativos/farmacologia
Compostos de Trimetil Amônio/farmacologia
[Mh] Termos MeSH secundário: Cardiolipinas/análise
Cardiolipinas/metabolismo
Clonagem Molecular
Polarização de Fluorescência
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Fases de Leitura Aberta
Fosfolipídeos/metabolismo
Pseudomonas putida/química
Pseudomonas putida/genética
Pseudomonas putida/metabolismo
Transferases (Outros Grupos de Fosfato Substituídos)/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cardiolipins); 0 (Membrane Proteins); 0 (Phospholipids); 0 (Surface-Active Agents); 0 (Trimethyl Ammonium Compounds); EC 2.7.8.- (Transferases (Other Substituted Phosphate Groups)); EC 2.7.8.- (cardiolipin synthetase); Y3IR7RCT6J (tetradecyltrimethylammonium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13238


  5 / 158 MEDLINE  
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[PMID]:27285732
[Au] Autor:Abozeid SM; Hathout RM; Abou-Aisha K
[Ad] Endereço:Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
[Ti] Título:Silencing of the metastasis-linked gene, AEG-1, using siRNA-loaded cholamine surface-modified gelatin nanoparticles in the breast carcinoma cell line MCF-7.
[So] Source:Colloids Surf B Biointerfaces;145:607-616, 2016 Sep 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cholamine surface-modified gelatin nanoparticles prepared by the double desolvation method using acetone as a dehydrating agent were selected and potentially evaluated as non viral vectors of siRNA targeting a metastatic gene AEG-1 in MCF-7 breast carcinoma cells. The ability of modified gelatin nanoparticle to complex and deliver siRNA for gene silencing was investigated. Hence, Particle size, surface charge (zeta potential) and morphology of siRNA/Gelatin nanoparticles (siGNPs) were characterized via dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscope (TEM). Moreover, the nanoparticles cytotoxicity, loading efficiency and interaction with MCF-7 human breast carcinoma cells were evaluated. Cationized GNPs of mean size range of 174nm and PDI of 0.101 were produced. The loading efficiency of siGNPs at a Nitrogen/Phosphate (N/P) ratio (w/w) of 200:1 was approximately 96%. Cellular uptake was evaluated after FITC conjugation where the particles produced high transfection efficiency. Finally, ELISA analysis of AEG-1/MTDH expression demonstrated the gene silencing effect of siGNPs, as more than 75% MTDH protein were inhibited. Our data indicate that cholamine modified GNPs pose a promising non-viral siRNA carrier for altering gene expression in MCF-7 breast cancer cells with many advantages such as relatively high gene transfection efficiency and efficient silencing ability.
[Mh] Termos MeSH primário: Neoplasias da Mama/genética
Neoplasias da Mama/patologia
Moléculas de Adesão Celular/genética
Gelatina/química
Inativação Gênica
Nanopartículas/química
RNA Interferente Pequeno/metabolismo
Compostos de Trimetil Amônio/farmacologia
[Mh] Termos MeSH secundário: Animais
Cátions
Moléculas de Adesão Celular/metabolismo
Morte Celular/efeitos dos fármacos
Endocitose/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Feminino
Fluoresceína-5-Isotiocianato/metabolismo
Fluorescência
Inativação Gênica/efeitos dos fármacos
Glutaral/química
Seres Humanos
Células MCF-7
Nanopartículas/ultraestrutura
Metástase Neoplásica
Tamanho da Partícula
Sus scrofa
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Cell Adhesion Molecules); 0 (MTDH protein, human); 0 (RNA, Small Interfering); 0 (Trimethyl Ammonium Compounds); 0 (cholamine); 9000-70-8 (Gelatin); I223NX31W9 (Fluorescein-5-isothiocyanate); T3C89M417N (Glutaral)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE


  6 / 158 MEDLINE  
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[PMID]:26925774
[Au] Autor:Marisa Heredia R; Sabrina Boeris P; Sebastián Liffourrena A; Fernanda Bergero M; Alberto López G; Inés Lucchesi G
[Ad] Endereço:Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, CPX5804BYA Río Cuarto, Córdoba, Argentina.
[Ti] Título:Release of outer membrane vesicles in Pseudomonas putida as a response to stress caused by cationic surfactants.
[So] Source:Microbiology;162(5):813-22, 2016 May.
[Is] ISSN:1465-2080
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pseudomonas putida A (ATCC 12633), a degrader of cationic surfactants, releases outer membrane vesicles (OMVs) when grown with tetradecyltrimethylammonium bromide (TTAB) as the sole carbon, nitrogen and energy source. The OMVs exhibit a bilayer structure and were found to be composed of lipopolysaccharides, proteins and phospholipids (PLs) such as cardiolipin, phosphatidylcholine, phosphatidic acid and phosphatidylglycerol (PG). The OMVs showed a marked increase in the PG content, approximately 43 % higher than the amount registered in the parent cells from which the vesicles were derived. After growth of P. putida with TTAB, the amount of lipoprotein covalently cross-linked to the peptidoglycan showed a twofold decrease when compared with values found after growth without the surfactant [16 ± 2 and 28 ± 3 µg (mg cell envelope protein)- 1, respectively]. This decrease in the amount of lipoprotein can be related to areas of loss of contact between the outer membrane and the peptidoglycan and, therefore, to OMV production. In addition, due to its amphiphilic nature, TTAB can contribute to OMV biogenesis, through a physical mechanism, by induction of the curvature of the membrane. Taking into account that OVMs were produced when the cells were grown under external stress, caused by the surfactant, and that TTAB was detected in the vesicles [48 nmol TTAB (nmol PL)- 1], we concluded that this system of TTAB elimination is a mechanism that P. putida A (ATCC 12633) would utilize for alleviating stress caused by cationic surfactants.
[Mh] Termos MeSH primário: Membrana Celular/metabolismo
Vesículas Extracelulares/metabolismo
Pseudomonas putida/metabolismo
Estresse Fisiológico/fisiologia
Tensoativos/farmacologia
Compostos de Trimetil Amônio/farmacologia
[Mh] Termos MeSH secundário: Animais
Cardiolipinas/metabolismo
Lipoproteínas/metabolismo
Peptidoglicano/metabolismo
Ácidos Fosfatídicos/metabolismo
Fosfatidilcolinas/metabolismo
Fosfatidilgliceróis/metabolismo
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiolipins); 0 (Lipoproteins); 0 (Peptidoglycan); 0 (Phosphatidic Acids); 0 (Phosphatidylcholines); 0 (Phosphatidylglycerols); 0 (Surface-Active Agents); 0 (Trimethyl Ammonium Compounds); Y3IR7RCT6J (tetradecyltrimethylammonium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1099/mic.0.000265


  7 / 158 MEDLINE  
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[PMID]:26915807
[Au] Autor:Bingol K; Bruschweiler-Li L; Li D; Zhang B; Xie M; Brüschweiler R
[Ad] Endereço:Pacific Northwest National Laboratory, Richland, WA 99352, USA.
[Ti] Título:Emerging new strategies for successful metabolite identification in metabolomics.
[So] Source:Bioanalysis;8(6):557-73, 2016 Mar.
[Is] ISSN:1757-6199
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This review discusses strategies for the identification of metabolites in complex biological mixtures, as encountered in metabolomics, which have emerged in the recent past. These include NMR database-assisted approaches for the identification of commonly known metabolites as well as novel combinations of NMR and MS analysis methods for the identification of unknown metabolites. The use of certain chemical additives to the NMR tube can permit identification of metabolites with specific physical chemical properties.
[Mh] Termos MeSH primário: Metabolômica
Preparações Farmacêuticas/metabolismo
[Mh] Termos MeSH secundário: Bases de Dados Factuais
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Metaboloma
Compostos de Trimetil Amônio/análise
Compostos de Trimetil Amônio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Trimethyl Ammonium Compounds); 0 (cholamine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160227
[St] Status:MEDLINE
[do] DOI:10.4155/bio-2015-0004


  8 / 158 MEDLINE  
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[PMID]:25892566
[Au] Autor:Deng J; Lu X; Constant C; Dogariu A; Fang J
[Ad] Endereço:Department of Materials Science and Engineering, University of Central Florida, Orlando, Florida 32816, USA. jfang@mail.ucf.edu.
[Ti] Título:Design of ß-CD-surfactant complex-coated liquid crystal droplets for the detection of cholic acid via competitive host-guest recognition.
[So] Source:Chem Commun (Camb);51(43):8912-5, 2015 May 28.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:ß-CD-C14TAB complex-coated 5CB droplets are designed by the adsorption of ß-CD-C14TAB complexes at the 5CB/aqueous interface. We show that the 5CB droplets can be used as an optical probe for the selective detection of cholic acid in aqueous solution containing uric acid and urea via competitive host-guest recognition.
[Mh] Termos MeSH primário: Ácido Cólico/análise
Cristais Líquidos/química
Espectrometria de Fluorescência
Tensoativos/química
beta-Ciclodextrinas/química
[Mh] Termos MeSH secundário: Ácido Cólico/urina
Seres Humanos
Microscopia Confocal
Compostos de Trimetil Amônio/química
Ureia/química
Ácido Úrico/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Surface-Active Agents); 0 (Trimethyl Ammonium Compounds); 0 (beta-Cyclodextrins); 268B43MJ25 (Uric Acid); 8W8T17847W (Urea); G1JO7801AE (Cholic Acid); Y3IR7RCT6J (tetradecyltrimethylammonium)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150514
[Lr] Data última revisão:
150514
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150421
[St] Status:MEDLINE
[do] DOI:10.1039/c5cc01561h


  9 / 158 MEDLINE  
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[PMID]:25890118
[Au] Autor:Xu H; Zhang H; Wang D; Wu L; Liu X; Jiao Z
[Ad] Endereço:Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
[Ti] Título:A facile route for rapid synthesis of hollow mesoporous silica nanoparticles as pH-responsive delivery carrier.
[So] Source:J Colloid Interface Sci;451:101-7, 2015 Aug 01.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this paper, a facile and effective route has been developed for rapid synthesis of hollow mesoporous silica nanoparticles (HMSNs) by using tetradecyltrimethylammonium bromide (TTAB) as the porogen with the assistance of triethanolamine (TEA). The products were characterized by various techniques including TEM, SEM, BET, and FT-IR, etc. The HMSNs obtained possess spherical morphology, mesoporous channels and very high specific surface areas (1355m(2)g(-1)). According to the experimental results, a possible formation mechanism was discussed. Moreover, the ability of HMSNs as drug carrier was evaluated by selecting doxorubicin hydrochloride (DOX) as the model drug. The results indicated that HMSNs showed high loading capacity and controlled pH-responsive release behavior. Considering their unique nanostructures and porous properties, we expect the HMSNs prepared have more potential applications in various fields such as nanoreactors, cellular imaging, and biosensor.
[Mh] Termos MeSH primário: Preparações de Ação Retardada/química
Nanopartículas/química
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Antibióticos Antineoplásicos/administração & dosagem
Preparações de Ação Retardada/síntese química
Doxorrubicina/administração & dosagem
Concentração de Íons de Hidrogênio
Nanopartículas/ultraestrutura
Porosidade
Compostos de Trimetil Amônio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (Delayed-Action Preparations); 0 (Trimethyl Ammonium Compounds); 7631-86-9 (Silicon Dioxide); 80168379AG (Doxorubicin); Y3IR7RCT6J (tetradecyltrimethylammonium)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150429
[Lr] Data última revisão:
150429
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150419
[St] Status:MEDLINE


  10 / 158 MEDLINE  
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[PMID]:25807451
[Au] Autor:Fegyver E; Mészáros R
[Ad] Endereço:†Laboratory of Interfaces and Nanosized Systems, Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, Pázmány Péter sétány 1/A, Hungary.
[Ti] Título:Complexation between Sodium Poly(styrenesulfonate) and Alkyltrimethylammonium Bromides in the Presence of Dodecyl Maltoside.
[So] Source:J Phys Chem B;119(16):5336-46, 2015 Apr 23.
[Is] ISSN:1520-5207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present paper, the impact of dodecyl maltoside (C12G2) on the association of sodium poly(styrenesulfonate) (PSS) with dodecyl- and hexadecyltrimethylammonium bromides (DTAB and CTAB) was studied. A low amount of nonionic surfactant enhances the binding of the investigated cationic amphiphiles on PSS, reducing the cationic surfactant-to-polyanion ratio needed for charge neutralization and precipitation. This effect is more pronounced for DTAB than for CTAB due to the considerably higher free surfactant concentration of the former cationic amphiphile. The synergistic surfactant binding also affects the nonequilibrium features of PSS/CTAB association via enhancing the kinetically stable concentration range of overcharged polyion/surfactant nanoparticle dispersions. With increasing C12G2 concentration, however, an opposite effect of the uncharged additive dominates. Namely, the CTAB molecules are solubilized excessively into mixed surfactant micelles, which reduces the surface charge of the PSS/CTAB/C12G2 nanoparticles and thus destabilizes their dispersion. At appropriately large nonionic surfactant concentrations, the binding of CTAB is largely reduced, resulting in the redissolution of the precipitate. In contrast, neither the destabilization nor the resolubilization effects of the added dodecyl maltoside were observed for the PSS/DTAB system due to the much lower driving force of DTAB binding compared to CTAB. Our results clearly demonstrate that the alkyl chain length of the ionic amphiphile has a pronounced effect on both the equilibrium and nonequilibrium aspects of polyion/mixed surfactant complexation which might be further exploited in various next generation applications.
[Mh] Termos MeSH primário: Brometos/química
Glucosídeos/química
Poliestirenos/química
Tensoativos/química
Compostos de Trimetil Amônio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bromides); 0 (Glucosides); 0 (Polystyrenes); 0 (Surface-Active Agents); 0 (Trimethyl Ammonium Compounds); 69227-93-6 (dodecyl maltoside); 70KO0R01RY (polystyrene sulfonic acid)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150423
[Lr] Data última revisão:
150423
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150326
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jpcb.5b01206



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