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  1 / 1295 MEDLINE  
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[PMID]:15852673
[Au] Autor:Koroku M; Tanda H; Katoh S; Onishi S; Nakajima H; Nanbu A; Nitta T; Akagashi K; Satoh Y; Hanzawa T
[Ad] Endereço:Department of Sanjyukai Hospital.
[Ti] Título:[Malacoplakia in the ureter and bladder].
[So] Source:Hinyokika Kiyo;51(3):183-5, 2005 Mar.
[Is] ISSN:0018-1994
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We report a case of malacoplakia in the ureter and bladder. A 78-year-old woman was admitted to our department for detailed examination of hydronephrosis. A small-fingertip-sized tumorous yellowish white lesion was detected by cytoscopy at a site that appeared to be the right side of the ureteral orifice. Transurethral resection was performed on the same site. Flat yellowish white protruding lesions were seen at two sites on the right ureter. Michaelis-Gutmann bodies were observed in biopsy specimens from both the bladder and ureter, and a diagnosis of malacoplakia was made. Ascorbic acid and bethanechol chloride were administered postoperatively. Endoscopy performed three months after the operation showed that the protruding lesions in the bladder and ureter had disappeared. Narrowing of the ureter or vesicoureteral reflux has not been seen to date.
[Mh] Termos MeSH primário: Malacoplasia/diagnóstico
Doenças Ureterais/diagnóstico
Doenças da Bexiga Urinária/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Ácido Ascórbico/administração & dosagem
Compostos de Betanecol/administração & dosagem
Quimioterapia Combinada
Feminino
Seres Humanos
Hidronefrose/complicações
Malacoplasia/tratamento farmacológico
Doenças Ureterais/tratamento farmacológico
Doenças da Bexiga Urinária/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bethanechol Compounds); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:0505
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050428
[St] Status:MEDLINE


  2 / 1295 MEDLINE  
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[PMID]:14726613
[Au] Autor:Jaworek J; Bonior J; Konturek SJ; Bilski J; Szlachcic A; Pawlik WW
[Ad] Endereço:Chair of Physiology Jagiellonian University School of Medicine, Kraków, Poland. mpjawore@cyf-kr.edu.pl
[Ti] Título:Role of leptin in the control of postprandial pancreatic enzyme secretion.
[So] Source:J Physiol Pharmacol;54(4):591-602, 2003 Dec.
[Is] ISSN:0867-5910
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Leptin released by adipocytes has been implicated in the control of food intake but recent detection of specific leptin receptors in the pancreas suggests that this peptide may also play some role in the modulation of pancreatic function. This study was undertaken to examine the effect of exogenous leptin on pancreatic enzyme secretion in vitro using isolated pancreatic acini, or in vivo in conscious rats with chronic pancreatic fistulae. Leptin plasma level was measured by radioimmunoassay following leptin administration to the animals. Intraperitoneal (i.p.) administration of leptin (0.1, 1, 5, 10, 20 or 50 microg/kg), failed to affect significantly basal secretion of pancreatic protein, but markedly reduced that stimulated by feeding. The strongest inhibition has been observed at dose of 10 microg/kg of leptin. Under basal conditions plasma leptin level averaged about 0.15 +/- 0.04 ng/ml and was increased by feeding up to 1.8 +/- 0.4 ng/ml. Administration of leptin dose-dependently augmented this plasma leptin level, reaching about 0.65 +/- 0.04 ng/ml at dose of 10 microg/kg of leptin. This dose of leptin completely abolished increase of pancreatic protein output produced by ordinary feeding, sham feeding or by diversion of pancreatic juice to the exterior. Leptin (10(-10)-10(-7) M) also dose-dependently attenuated caerulein-induced amylase release from isolated pancreatic acini, whereas basal enzyme secretion was unaffected. We conclude that leptin could take a part in the inhibition of postprandial pancreatic secretion and this effect could be related, at least in part, to the direct action of this peptide on pancreatic acini.
[Mh] Termos MeSH primário: Leptina/fisiologia
Pâncreas/secreção
Período Pós-Prandial/fisiologia
[Mh] Termos MeSH secundário: Animais
Compostos de Betanecol/farmacologia
Ceruletídeo/farmacologia
Doença Crônica
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Esquema de Medicação
Avaliação Pré-Clínica de Medicamentos/métodos
Quimioterapia Combinada
Ingestão de Alimentos/fisiologia
Fístula Gástrica/etiologia
Fístula Gástrica/fisiopatologia
Injeções Intraperitoneais
Leptina/sangue
Leptina/farmacologia
Pâncreas/citologia
Pâncreas/efeitos dos fármacos
Fístula Pancreática/etiologia
Fístula Pancreática/fisiopatologia
Suco Pancreático/efeitos dos fármacos
Suco Pancreático/enzimologia
Suco Pancreático/secreção
Período Pós-Prandial/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (Leptin); 888Y08971B (Ceruletide)
[Em] Mês de entrada:0409
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040117
[St] Status:MEDLINE


  3 / 1295 MEDLINE  
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[PMID]:11998089
[Au] Autor:Bernier F; Davila GW
[Ad] Endereço:Continence Education Program, Colorado Gynecology and Continence Center, Denver, USA.
[Ti] Título:The treatment of nonobstructive urinary retention with high-frequency transvaginal electrical stimulation.
[So] Source:Urol Nurs;20(4):261-4, 2000 Aug.
[Is] ISSN:1053-816X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The usefulness of timed voiding, cholinergic medications, and high-frequency electrical stimulation in women with symptomatic urinary retention was evaluated. Results indicated that symptomatic urinary retention can be treated with behavioral modification and high-frequency electrical stimulation. Optimal results were found in younger women with stable bladders.
[Mh] Termos MeSH primário: Terapia por Estimulação Elétrica
Retenção Urinária/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Compostos de Betanecol/uso terapêutico
Terapia Combinada
Feminino
Seres Humanos
Meia-Idade
Agonistas Muscarínicos/uso terapêutico
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (Muscarinic Agonists)
[Em] Mês de entrada:0206
[Cu] Atualização por classe:100426
[Lr] Data última revisão:
100426
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:020510
[St] Status:MEDLINE


  4 / 1295 MEDLINE  
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[PMID]:10898103
[Au] Autor:Jaworek J; Bilski J; Jachimczak B; Cieszkowski M; Kot M; Bielanski W; Konturek SJ
[Ad] Endereço:Chair of Physiology University School of Medicine Jagiellonian University, Kraków, Poland.
[Ti] Título:The effects of ammonia on pancreatic enzyme secretion in vivo and in vitro.
[So] Source:J Physiol Pharmacol;51(2):315-32, 2000 Jun.
[Is] ISSN:0867-5910
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recent studies clearly demonstrate that Helicobacter pylori (H. pylori) infection of the stomach causes persistent elevation of ammonia (NH3) in gastric juice leading to hypergastrinemia and enhanced pancreatic enzyme secretion. METHODS: The aim of this study is to evaluate the influence of NH4OH on plasma gastrin level and exocrine pancreatic secretion in vivo in conscious dogs equipped with chronic pancreatic fistulas and on secretory activity of in vitro isolated acini obtained from the rat pancreas by collagenase digestion. The effects of NH4OH on amylase release from pancreatic acini were compared with those produced by simple alkalization of these acini with NaOH. RESULTS: NH4OH given intraduodenally (i.d.) in increasing concentrations (0.5, 1.0, 2.0, 4.0, or 8.0 mM/L) resulted in an increase of pancreatic protein output, reaching respectively 9%, 10%, 19%, 16% and 17% of caerulein maximum in these animals and in a marked increase in plasma gastrin level. NH4OH (8 x 0 mM/L, i.d.) given during intravenous (i.v.) infusion of secretin (50 pmol/kg-h) and cholecystokinin (50 pmol/kg-h) reduced the HCO3 and protein outputs by 35% and 37% respectively, as compared to control obtained with infusion of secretin plus cholecystokinin alone. When pancreatic secretion was stimulated by ordinary feeding the same amount of NH4OH administered i.d. decreased the HCO3- and protein responses by 78% and 47% respectively, and had no significant effect on postprandial plasma gastrin. In isolated pancreatic acini, increasing concentrations of NH4OH (10(-7)-10(-4) M) produced a concentration-dependent stimulation of amylase release, reaching about 43% of caerulein-induced maximum. When various concentrations of NH4OH were added to submaximal concentration of caerulein (10(-12) M) or urecholine (10(-5) M), the enzyme secretion was reduced at a dose 10(-5) M of NH4OH by 38% or 40%, respectively. Simple alkalization with NaOH of the incubation medium up to pH 8.5 markedly stimulated basal amylase secretion from isolated pancreatic acini, whereas the secretory response of these acini to pancreatic secretagogues was significantly diminished by about 30%. LDH release into the incubation medium was not significantly changed in all tests indicating that NH4OH did not produce any apparent damage of pancreatic acini and this was confirmed by histological examination of these acini. CONCLUSIONS: 1. NH4OH affects basal and stimulated pancreatic secretion. 2. The excessive release of gastrin may be responsible for the stimulation of basal pancreatic enzyme secretion in conscious animals, and 3. The inhibitory effects of NH4OH on stimulated secretion might be mediated, at least in part, by its direct action on the isolated pancreatic acini possibly due to the alkalization of these acini.
[Mh] Termos MeSH primário: Amônia/farmacologia
Pâncreas/enzimologia
Pâncreas/secreção
[Mh] Termos MeSH secundário: Álcalis/farmacologia
Hidróxido de Amônia
Amilases/metabolismo
Animais
Compostos de Betanecol/farmacologia
Ceruletídeo/farmacologia
Cães
Ingestão de Alimentos/fisiologia
Enzimas/efeitos dos fármacos
Enzimas/metabolismo
Gastrinas/sangue
Hidróxidos/farmacologia
Técnicas In Vitro
L-Lactato Desidrogenase/metabolismo
Hidróxido de Sódio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkalies); 0 (Bethanechol Compounds); 0 (Enzymes); 0 (Gastrins); 0 (Hydroxides); 5138Q19F1X (Ammonium Hydroxide); 55X04QC32I (Sodium Hydroxide); 7664-41-7 (Ammonia); 888Y08971B (Ceruletide); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.2.1.- (Amylases)
[Em] Mês de entrada:0010
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000718
[St] Status:MEDLINE


  5 / 1295 MEDLINE  
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[PMID]:10697692
[Au] Autor:Metwally E; Davison JS; Mathison RD
[Ad] Endereço:Department of Physiology and Biophysics, University of Calgary, Alberta, Canada.
[Ti] Título:Tyrosine is detrimental to the biological activity of submandibular gland peptide-T (SGP-T).
[So] Source:Proc West Pharmacol Soc;42:65-6, 1999.
[Is] ISSN:0083-8969
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Oligopeptídeos/antagonistas & inibidores
Tirosina/farmacologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Anafilaxia/fisiopatologia
Animais
Compostos de Betanecol/farmacologia
Sítios de Ligação
Técnicas In Vitro
Lisina/química
Masculino
Dados de Sequência Molecular
Contração Muscular/efeitos dos fármacos
Oligopeptídeos/síntese química
Oligopeptídeos/química
Ovalbumina/imunologia
Ratos
Ratos Sprague-Dawley
Tirosina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (Oligopeptides); 0 (submandibular gland peptide T); 42HK56048U (Tyrosine); 9006-59-1 (Ovalbumin); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:0004
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000304
[St] Status:MEDLINE


  6 / 1295 MEDLINE  
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[PMID]:9801129
[Au] Autor:Dion SB; Zvara P; Tu LM; Richer M; Corcos J
[Ad] Endereço:Urology Research Laboratories, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Québec, Canada.
[Ti] Título:Evaluation of the role of neurolinins and urecholine hypersensitivity in an animal model of infravesical outflow obstruction.
[So] Source:Urology;52(5):909-14, 1998 Nov.
[Is] ISSN:0090-4295
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To determine whether detrusor muscle strips from a male rat with infravesical outflow obstruction model demonstrate supersensitivity to parasympathomimetic and neurokinin NK-1 and NK-2 selective agonists. METHODS: Bladder instability developed after 6 weeks of partial urethral obstruction. The micturition frequency and voided volume were determined in unanesthetized animals. Detrusor hypertrophy was confirmed by evaluation of bladder weight. In vitro organ bath was used to compare the affinity and maximal activity of bethanechol and neurokinin NK-1 and NK-2 selective agonists on strips from the detrusor muscle of sham and obstructed rats. Bethanechol, N-Ac[Arg6, Sar9, Met(O2)]-SP(6-11), and [beta-Ala8]-NKA(4-10) were used to characterize cholinergic muscarinic, neurokinin NK-1 and NK-2 receptors. Results. No significant differences in affinities and maximal responses were found using 10-mg detrusor muscle strips with each of the three agonists. CONCLUSIONS: Bladder instability produced by outlet obstruction does not involve changes in the affinity or maximal activity of cholinergic muscarinic, neurokinin NK-1 and NK-2 receptors. Furthermore, detrusor supersensitivity to neurokinins or bethanechol was not seen. This suggests that bladder instability is not due to an increased affinity or maximal response to neurokinins or parasympathomimetics.
[Mh] Termos MeSH primário: Compostos de Betanecol/farmacologia
Neurocinina B/agonistas
Receptores da Neurocinina-1/efeitos dos fármacos
Receptores da Neurocinina-2/efeitos dos fármacos
Obstrução Uretral/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Técnicas In Vitro
Masculino
Músculo Liso
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (Receptors, Neurokinin-1); 0 (Receptors, Neurokinin-2); 86933-75-7 (Neurokinin B)
[Em] Mês de entrada:9812
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:981104
[St] Status:MEDLINE


  7 / 1295 MEDLINE  
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[PMID]:9387036
[Au] Autor:Jaworek J; Konturek SJ; Szlachcic A
[Ad] Endereço:Institute of Physiology, Colleguim Medicum Jagiellonian University, Kraków, Poland.
[Ti] Título:The role of CGRP and afferent nerves in the modulation of pancreatic enzyme secretion in the rat.
[So] Source:Int J Pancreatol;22(2):137-46, 1997 Oct.
[Is] ISSN:0169-4197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONCLUSION: Stimulation of pancreatic sensory nerves by capsaicin produced secretory effects probably caused, at least in part, by the release of CGRP. BACKGROUND: In the pancreas calcitonin gene-related peptide (CGRP) has been localized in the sensory nerves, but its physiological role is unknown. This study was undertaken to compare the changes of pancreatic enzyme secretion produced by CGRP and by stimulation or destruction of sensory nerves. METHODS: To stimulate sensory nerves, low doses of capsaicin (0.25-0.5 mg/kg) were given intraduodenally to the conscious rats with chronic pancreatic fistula. To inactivate sensory nerves high doses of capsaicin (100 mg/kg) were given subcutaneously 10 d before tests. For the in vitro experiments pancreatic slices and isolated pancreatic acini were prepared from intact and capsaicin-denervated rats. RESULTS: In conscious rats, CGRP given subcutaneously (5-10 micrograms/kg) and low doses of capsaicin given intraduodenally reduced basal pancreatic secretion. In isolated pancreatic acini, CGRP (10(-10)-10(-6) M), but not capsaicin, increased basal or secretagog-stimulated amylase release. In pancreatic slices (containing nerve fibers) capsaicin (10(-10)-10(-6) M) increased enzyme secretion, and this secretion was abolished by previous inactivation of sensory nerves by this neurotoxin. Capsaicin deactivation did not affect the secretory response of pancreatic acini to CGRP, cerulein, or urecholine. Sensory denervation by capsaicin did not change basal protein secretion, but reduced that produced by feeding or diversion of pancreatic juice to the exterior during first 2 h of the tests.
[Mh] Termos MeSH primário: Peptídeo Relacionado com Gene de Calcitonina/fisiologia
Neurônios Aferentes/fisiologia
Pâncreas/inervação
Pâncreas/secreção
[Mh] Termos MeSH secundário: Amilases/secreção
Animais
Compostos de Betanecol/farmacologia
Peptídeo Relacionado com Gene de Calcitonina/farmacologia
Capsaicina/administração & dosagem
Ceruletídeo/farmacologia
Relação Dose-Resposta a Droga
Técnicas In Vitro
Masculino
Neurônios Aferentes/efeitos dos fármacos
Pâncreas/efeitos dos fármacos
Fístula Pancreática
Ratos
Ratos Wistar
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bethanechol Compounds); 83652-28-2 (Calcitonin Gene-Related Peptide); 888Y08971B (Ceruletide); EC 3.2.1.- (Amylases); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:9802
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:971205
[St] Status:MEDLINE


  8 / 1295 MEDLINE  
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[PMID]:8832913
[Au] Autor:Lin W-C
[Ad] Endereço:Department of Pharmacology, China Medical College, Taiwan.
[Ti] Título:Potentiation by baclofen of gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia.
[So] Source:Res Commun Mol Pathol Pharmacol;91(2):211-24, 1996 Feb.
[Is] ISSN:1078-0297
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effect of intravenous administration of baclofen, a GABA(B) receptor agonist, on gastric acid secretion from perfused stomach was studied in vagotomized rats anesthetized with urethane. Baclofen did not stimulate acid secretion by itself. In contrast, baclofen dose-dependently potentiated acid secretion induced by pentagastrin, bethanechol and direct vagal stimulation, but not by histamine. Baclofen-potentiated acid secretion induced by pentagastrin and bethanechol was not influenced by pretreatment with atropine or cimetidine, respectively. Baclofen-potentiated acid secretion evoked by direct vagal stimulation was prevented by pretreatment with proglumide which is a gastrin receptor antagonist. Baclofen-potentiated acid secretion evoked by bethanechol was partly prevented by bicuculline methiodide which is a GABA(A) receptor antagonist, but not by phaclofen which is a GABA(B) receptor antagonist, suggesting an involvement of peripheral GABA(A) receptors. Baclofen-potentiated acid secretion induced by direct vagal stimulation was not affected by the change of body temperature. These results suggest that baclofen stimulates acid secretion under certain conditions, and that two mechanisms are involved in this effect. The effects of baclofen on acid secretion may be mediated by increasing the release of histamine by pentagastrin, bethanechol and direct vagal stimulation. In addition, baclofen would also be effective if muscarinic agents were already occupying muscarinic acetylcholine receptors on parietal cells.
[Mh] Termos MeSH primário: Baclofeno/farmacologia
Agonistas GABAérgicos/farmacologia
Ácido Gástrico/secreção
Vagotomia
[Mh] Termos MeSH secundário: Anestesia
Animais
Baclofeno/análogos & derivados
Compostos de Betanecol/farmacologia
Temperatura Corporal/fisiologia
Relação Dose-Resposta a Droga
Sinergismo Farmacológico
Estimulação Elétrica
Antagonistas GABAérgicos/farmacologia
Masculino
Pentagastrina/farmacologia
Ratos
Ratos Wistar
Uretana
Nervo Vago/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (GABA Agonists); 0 (GABA Antagonists); 108351-35-5 (phaclofen); 3IN71E75Z5 (Urethane); EF0NX91490 (Pentagastrin); H789N3FKE8 (Baclofen)
[Em] Mês de entrada:9705
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960201
[St] Status:MEDLINE


  9 / 1295 MEDLINE  
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[PMID]:8770789
[Au] Autor:Bilski J; Konturek SJ; Bielanski W
[Ad] Endereço:Institute of Physiology, Jagiellonian University School of Medicine, Cracow, Poland.
[Ti] Título:Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion.
[So] Source:J Physiol Pharmacol;46(4):447-62, 1995 Dec.
[Is] ISSN:0867-5910
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:L-Arginine (L-Arg), that is a substrate for nitric oxide (NO) synthase, stimulates the release of pancreatic islet hormones but the mechanism of this stimulation is unknown. The aim of this study was to determine the role of NO in the control of endocrine and exocrine pancreatic secretion in response to sham feeding (SF), ordinary meat feeding (F), duodenal perfusion with nutrients and i.v. infusion of gastrin releasing peptide (GRP) or urecholine in conscious dogs with chronic pancreatic fistulas. SF1 F, duodenal nutrient and GRP and urecholine resulted in the stimulation of pancreatic secretion reaching, respectively, 50%, 50%, 40%, 85% and 20% of maximal response to caerulein (200 pmol/kg-h i.v.). Infusion of L-Arg (50 mg/kg + 5 mg/kg-h i.v.) almost doubled the basal pancreatic protein secretion and significantly increased the secretory response to SF, F, and duodenal nutrient. After i.v. administration of L-NNA (2.5 mg/kg + 0.5 mg/kg-h), an inhibitor of NO synthase, the pancreatic secretory responses to SF, F, duodenal nutrient, GRP and urecholine were significantly inhibited by about 74%, 70%, 70%, 80% and 30%, respectively. When L-Arg was combined with L-NNA, the reduction in pancreatic secretion induced by L-NNA was significantly attenuated. SF resulted in a marked rise in plasma insulin and glucagon and this response was completely abolished by L-NNA infusion. Insulin and glucagon levels were 2-3 folds increased by F and L-NNA infusion inhibited these responses while the addition of L-Arg partly reversed this inhibition. Duodenal nutrient produced several fold increase in plasma insulin and glucagon levels that were significantly reduced by L-NNA and this reduction was partially reversed by L-Arg. GRP also caused moderate rise in plasma insulin and glucagon levels which were significantly reduced by L-NNA and this was partially restored by L-Arg. We conclude that SF, F, duodenal nutrient, GRP or urecholine stimulate both the exocrine and endocrine pancreatic secretion and that these effects are mediated, at least in part, through the NO pathway.
[Mh] Termos MeSH primário: Ilhotas Pancreáticas/fisiologia
Óxido Nítrico/fisiologia
Pâncreas/fisiologia
[Mh] Termos MeSH secundário: Animais
Arginina/análogos & derivados
Arginina/farmacologia
Compostos de Betanecol/farmacologia
Depressão Química
Cães
Ingestão de Alimentos/fisiologia
Inibidores Enzimáticos/farmacologia
Glucagon/sangue
Insulina/sangue
Ilhotas Pancreáticas/inervação
Ilhotas Pancreáticas/secreção
Óxido Nítrico Sintase/antagonistas & inibidores
Nitroarginina
Pâncreas/inervação
Pâncreas/secreção
Hormônios Pancreáticos/farmacologia
Sistema Nervoso Parassimpático/fisiologia
Proteínas/metabolismo
Nervo Vago/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (Enzyme Inhibitors); 0 (Insulin); 0 (Pancreatic Hormones); 0 (Proteins); 2149-70-4 (Nitroarginine); 31C4KY9ESH (Nitric Oxide); 9007-92-5 (Glucagon); 94ZLA3W45F (Arginine); EC 1.14.13.39 (Nitric Oxide Synthase)
[Em] Mês de entrada:9610
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:951201
[St] Status:MEDLINE


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Fotocópia
[PMID]:8690239
[Au] Autor:Longhurst PA; Leggett RE; Briscoe JA
[Ad] Endereço:Department of Pharmacology, University of Pennysylvania School of Medicine, Philadelphia 19104, USA.
[Ti] Título:Influence of strip size and location on contractile responses of rat urinary bladder body strips.
[So] Source:Gen Pharmacol;26(7):1519-27, 1995 Nov.
[Is] ISSN:0306-3623
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. We investigated the influence of strip length and dorsal or ventral location of rat urinary bladder strips on contractile responsiveness. 2. No differences occurred in the contractile responses of 0.5, 1.0 and 2.0 cm strips to field stimulation, carbachol, ATP, substance P or to KCl when the data were expressed as either absolute tension or as tension per cross-sectional area. However, correction for strip mass resulted in significant decreases in the contractile responses of the 2.0-cm strips compared with the 0.5-cm strips. 3. No differences occurred in length-tension curves for ventral and dorsal bladder strips, even though the strips from the dorsal surface appeared thinner than those from the ventral surface. 4. Strips from the ventral surface exhibited more variability in response to field stimulation and were less sensitive to atropine pre-treatment than were those from the dorsal surface. They were also less sensitive to the contractile effects of carbachol than dorsal strips. Dorsal and ventral strips were equally responsive to ATP, substance P and KCl. 5. Our data indicate that the contractile responsiveness of rat urinary bladder strips is independent of strip length. Although there are some differences between the cholinergic responsiveness of strips from the ventral and dorsal surfaces of the bladder, the differences are so small that for most studies they will probably have no influence on data interpretation.
[Mh] Termos MeSH primário: Contração Muscular/efeitos dos fármacos
Bexiga Urinária/efeitos dos fármacos
[Mh] Termos MeSH secundário: Trifosfato de Adenosina
Animais
Atropina/farmacologia
Compostos de Betanecol/farmacologia
Carbacol/farmacologia
Masculino
Agonistas Muscarínicos/farmacologia
Antagonistas Muscarínicos/farmacologia
Ratos
Ratos Sprague-Dawley
Bexiga Urinária/anatomia & histologia
Bexiga Urinária/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Bethanechol Compounds); 0 (Muscarinic Agonists); 0 (Muscarinic Antagonists); 7C0697DR9I (Atropine); 8L70Q75FXE (Adenosine Triphosphate); 8Y164V895Y (Carbachol)
[Em] Mês de entrada:9608
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:951101
[St] Status:MEDLINE



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