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[PMID]:15950147
[Au] Autor:Broeders ME; Molema J; Hop WC; Folgering HT
[Ad] Endereço:Department of Pulmonary Diseases Dekkerswald, University of Nijmegen, P.O. Box 66, NL-6560 AB Groesbeek, The Netherlands. m.broeders@zonnet.nl
[Ti] Título:Bronchial challenge, assessed with forced expiratory manoeuvres and airway impedance.
[So] Source:Respir Med;99(8):1046-52, 2005 Aug.
[Is] ISSN:0954-6111
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The Methacholine concentration at which a 20% decrease of the forced expiratory volume in 1s (PC20_FEV1) or a 40% increase in airway resistance (PC40_Rrs6) occur are accepted indicators for airway hyperresponsiveness. We hypothesised that the level of detection of bronchial hyperresponsiveness will differ between the two methods. METHODS: The response to Methacholine was assessed by forced oscillation technique (FOT) and spirometry in 20 stable hyperresponsive asthmatics. The effects of repeated lung function measurements on respiratory muscle fatigue were measured from maximal inspiratory mouth pressure (MIP). After each dose, patients scored their perception of dyspnoea on a BORG scale. Differences in patient's burden were measured by comparing the BORG-score at PC40_Rrs6 (BORG-PC40_Rrs6) and at PC20_FEV1 (BORG-PC20_FEV1). Reproducibility was also evaluated. RESULTS: The PC20_FEV1-values were 2.2 (0.4) doubling dose higher as compared to the PC40_Rrs6 (P<0.001). The mean BORG-score at PC40_Rrs6 was 1.7 points lower as compared to the BORG-score at PC20_FEV1 (P<0.001). The difference (mean(sd)) between the PC20_FEV1 of measurement 1 and 2 was -0.1 (1.4) doubling dose, and -0.3 (2.7) doubling dose for PC40_Rrs6. The MIP after Methacholine provocation was 1.0(0.2) kPa lower as compared to the MIP before the challenge test (P<0.001), suggesting respiratory muscle fatigue. CONCLUSION: Measuring PC40_Rrs6 shortens the challenge test and lowers the concentrations of bronchoconstrictor agents as compared to measurements of PC20_FEV1. The FOT-method was less strenuous for patients. In spite of the fact that the reproducibility is two-fold worse than measuring PC20_FEV1, it still remains quite acceptable at a mean of 0.3 doubling dose. The respiratory muscle strength was deteriorated after the challenge test.
[Mh] Termos MeSH primário: Resistência das Vias Respiratórias/efeitos dos fármacos
Asma/fisiopatologia
Hiper-Reatividade Brônquica/diagnóstico
Testes de Provocação Brônquica/métodos
Volume Expiratório Forçado/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Hiper-Reatividade Brônquica/fisiopatologia
Broncoconstritores/administração & dosagem
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Compostos de Metacolina/administração & dosagem
Meia-Idade
Reprodutibilidade dos Testes
Músculos Respiratórios/efeitos dos fármacos
Músculos Respiratórios/fisiopatologia
Espirometria/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchoconstrictor Agents); 0 (Methacholine Compounds)
[Em] Mês de entrada:0601
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050614
[St] Status:MEDLINE


  2 / 2397 MEDLINE  
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[PMID]:12762349
[Au] Autor:Padoan M; Pozzato V; Simoni M; Zedda L; Milan G; Bononi I; Piola C; Maestrelli P; Boschetto P; Mapp CE
[Ad] Endereço:Dept of Environmental Medicine and Public Health, University of Padua, Padua, Italy.
[Ti] Título:Long-term follow-up of toluene diisocyanate-induced asthma.
[So] Source:Eur Respir J;21(4):637-40, 2003 Apr.
[Is] ISSN:0903-1936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eighty-seven cases of occupational asthma induced by toluene diisocyanate (TDI) were diagnosed by an inhalation challenge with TDI and methacholine. After an average follow-up interval of 11 yrs, all subjects were re-examined. Of the 87 subjects examined, 13 (15%) had remained in the same job, 44 (50.5%) had been removed from exposure for <10 yrs and 30 (34.5%) had been removed for >10 yrs. The proportion of subjects who experienced symptoms of asthma and those who were hyperresponsive to methacholine was significantly lower. Of the patients, 59% used short-acting bronchodilators, 8% long-acting bronchodilators and 18% were on regular inhaled glucocorticoids. Thus, multiple regression analysis showed a positive correlation between forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) at follow-up and FVC and FEV1 at diagnosis, and a negative correlation with smoking and with therapy with bronchodilators. Stepwise logistic regression showed that the follow-up provocative dose causing a 20% fall in the FEV1 (PD20) could be predicted from baseline PD20. These results indicate that respiratory symptoms and airway hyperresponsiveness to methacholine persist in subjects removed from exposure to TDI for >10 yrs. A more favourable prognosis was associated with a better lung function and a lower degree of airway hyperresponsiveness to methacholine at diagnosis.
[Mh] Termos MeSH primário: Asma/induzido quimicamente
Doenças Profissionais/induzido quimicamente
Tolueno 2,4-Di-Isocianato/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Asma/fisiopatologia
Testes de Provocação Brônquica
Feminino
Seguimentos
Seres Humanos
Modelos Logísticos
Estudos Longitudinais
Masculino
Cloreto de Metacolina
Compostos de Metacolina
Meia-Idade
Doenças Profissionais/fisiopatologia
Exposição Ocupacional
Prognóstico
Testes de Função Respiratória
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Methacholine Compounds); 0W5ETF9M2K (Methacholine Chloride); 17X7AFZ1GH (Toluene 2,4-Diisocyanate)
[Em] Mês de entrada:0309
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030524
[St] Status:MEDLINE


  3 / 2397 MEDLINE  
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[PMID]:12483011
[Au] Autor:Koh YI; Choi IS
[Ad] Endereço:Division of Allergy, Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Science, Gwangju, Korea. ischoi@chonnam.chonnam.ac.kr
[Ti] Título:Oropharyngeal angioedema induced by inhaled histamine.
[So] Source:J Korean Med Sci;17(6):830-2, 2002 Dec.
[Is] ISSN:1011-8934
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Inhaled histamine used to measure airway responsiveness produces some side effects more frequently than does methacholine. It is possible that the inhaled histamine induces the side effects in asthmatics with increased end organ responsiveness to histamine. A 56-yr-old woman with chronic idiopathic angioedema presented with asthma-like symptoms. Methacholine challenge test was performed, with a negative result. Five days later, histamine inhalation test was done. FEV1 fell by 37% after inhalation of histamine concentration of 8 mg/mL. Immediately thereafter, severe angioedema on face, lips, and oropharyngeal area, foreign body sensation at throat, and hoarseness occurred. To assess end organ responsiveness to histamine, skin prick tests with doubling concentrations of histamine (0.03-16 mg/mL) were carried out on the forearm of the patient and six age- and sex-matched asthmatic controls. The wheal areas were measured. The patient showed greater skin responses than the controls. Regression analysis showed that the intercept and slope were greater than cut-off levels determined from six controls. The patient showed an increased skin wheal response to histamine, indicating the enhanced end organ responsiveness to histamine, which is likely to contribute to the development of the oropharyngeal angioedema by inhaled histamine.
[Mh] Termos MeSH primário: Angioedema/etiologia
Histamina/administração & dosagem
Histamina/efeitos adversos
[Mh] Termos MeSH secundário: Testes de Provocação Brônquica
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Compostos de Metacolina/farmacologia
Meia-Idade
Nebulizadores e Vaporizadores
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methacholine Compounds); 820484N8I3 (Histamine)
[Em] Mês de entrada:0306
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:021217
[St] Status:MEDLINE


  4 / 2397 MEDLINE  
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[PMID]:11758470
[Au] Autor:Hots TIu
[Ad] Endereço:P.L. Shupik Medical Academy for Postgraduate Training, Kiev.
[Ti] Título:[The effects of ozone and toxic air particles on airway function in mice].
[Ti] Título:Vplyv ozonu ta toksychnykh chastok povitria na dykhal'ni shliakhy myshei..
[So] Source:Fiziol Zh;47(5):63-8, 2001.
[Is] ISSN:2522-9028
[Cp] País de publicação:Ukraine
[La] Idioma:ukr
[Ab] Resumo:We tested the hypothesis that exposures to particulate matter and ozone can produce asthma-like symptoms. Balb/c mice received a single intratracheal instillation of particulate matter and TiO2 or they were exposed to low concentration of ozone. We have established that exposure to particulate matter produces increased responsiveness to methacholine in mice. Exposure to ozone and TiO2 did not produce changes in respiratory mechanics. These data are spreading our understanding about mechanisms of environmental influence on airways.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/farmacologia
Brônquios/efeitos dos fármacos
Brônquios/fisiologia
Hiper-Reatividade Brônquica/etiologia
Ozônio/farmacologia
[Mh] Termos MeSH secundário: Animais
Testes de Provocação Brônquica
Masculino
Compostos de Metacolina/farmacologia
Camundongos
Camundongos Endogâmicos BALB C
Tamanho da Partícula
Testes de Função Respiratória
Titânio/farmacologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Methacholine Compounds); 15FIX9V2JP (titanium dioxide); 66H7ZZK23N (Ozone); D1JT611TNE (Titanium)
[Em] Mês de entrada:0207
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020105
[St] Status:MEDLINE


  5 / 2397 MEDLINE  
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[PMID]:10917853
[Au] Autor:Polosa R
[Ti] Título:Inhaled fluticasone.
[So] Source:Thorax;55(7):628-9, 2000 Jul.
[Is] ISSN:0040-6376
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Androstadienos
Antiasmáticos
Asma/diagnóstico
[Mh] Termos MeSH secundário: Anti-Inflamatórios/uso terapêutico
Asma/tratamento farmacológico
Diagnóstico Diferencial
Fluticasona
Seres Humanos
Pneumopatias Obstrutivas/diagnóstico
Compostos de Metacolina
Prednisolona/uso terapêutico
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Androstadienes); 0 (Anti-Asthmatic Agents); 0 (Anti-Inflammatory Agents); 0 (Methacholine Compounds); 9PHQ9Y1OLM (Prednisolone); CUT2W21N7U (Fluticasone)
[Em] Mês de entrada:0007
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000805
[St] Status:MEDLINE


  6 / 2397 MEDLINE  
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[PMID]:10903486
[Au] Autor:Waserman S; Dolovich J; Conway M; Marshall JS
[Ad] Endereço:Department of Medicine, McMaster University, Hamilton, Ontario, Canada. waserman@fhs.mcmaster.ca
[Ti] Título:TNF-alpha dysregulation in asthma: relationship to ongoing corticosteroidtherapy.
[So] Source:Can Respir J;7(3):229-37, 2000 May-Jun.
[Is] ISSN:1198-2241
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tumour necrosis factor-alpha (TNF-alpha) is a major proinflammatory cytokine that is thought to be important in the pathogenesis of asthma. However, alterations in systemic regulation of this cytokine in asthma have not been examined in the context of corticosteroid therapy. OBJECTIVES: To examine the ability of peripheral blood mononuclear cells (PBMC) from three different groups of patients with asthma requiring varying amounts of inhaled corticosteroids (ICS) for clinical control, and to examine cells from age- and sex-matched nonasthmatic patients to produce TNF-alpha. DESIGN: All patients with asthma had a positive methacholine challenge test. 'High dose' ICS patients with asthma required ICS greater than or equal to 800 microg/day. 'Medium dose' patients with asthma were on less than or equal to 500 microg/day of ICS, whereas 'no ICS' patients with asthma had received no ICS for at least three months. Each patient with asthma was examined in parallel with an age- and sex-matched, nonasthmatic, nonatopic control subject. Cells were cultured (with or without the addition of potential stimulators phytohemagglutinin, lipopolysaccharide, formyl-methionine-leucine-phenylalanine or antihuman CD3), and TNF-alpha production was assessed by ELISA. MAIN RESULTS: PBMC from both high dose ICS (n=8) and no ICS (n=11) patients with asthma produced more than twice the amount of TNF-alpha than cells from matched nonasthmatic control patients (P<0.01) when cultured alone or in the presence of each stimulus (P<0.05). In contrast, there was no significant difference in TNF-alpha production between medium dose ICS patients with asthma and control patients. A group of asymptomatic atopic patients (n=6) did not have an increased level of TNF-alpha production. CONCLUSIONS: Increases in TNF-a production within the PBMC compartment can be observed in both patients with asthma receiving high dose ICS and in a group of patients with mild asthma receiving no ICS therapy, but not in patients with asthma receiving a medium dose of ICS or atopic patients.
[Mh] Termos MeSH primário: Asma/metabolismo
Glucocorticoides/uso terapêutico
Fator de Necrose Tumoral alfa/biossíntese
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Idoso
Antiasmáticos/administração & dosagem
Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Asma/imunologia
Beclometasona/administração & dosagem
Beclometasona/uso terapêutico
Budesonida/administração & dosagem
Budesonida/uso terapêutico
Estudos de Casos e Controles
Células Cultivadas
Feminino
Glucocorticoides/administração & dosagem
Seres Humanos
Hipersensibilidade Imediata/metabolismo
Leucócitos Mononucleares/metabolismo
Masculino
Compostos de Metacolina/metabolismo
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Glucocorticoids); 0 (Methacholine Compounds); 0 (Tumor Necrosis Factor-alpha); 51333-22-3 (Budesonide); KGZ1SLC28Z (Beclomethasone)
[Em] Mês de entrada:0009
[Cu] Atualização por classe:160520
[Lr] Data última revisão:
160520
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000721
[St] Status:MEDLINE


  7 / 2397 MEDLINE  
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[PMID]:10814605
[Au] Autor:Ottanelli R; Rosi E; Romagnoli I; Ronchi MC; Lanini B; Grazzini M; Filippelli M; Stendardi L; Duranti R; Scano G
[Ad] Endereço:Section of Clinical Immunology and Respiratory Disease, Department of Internal Medicine, University of Florence, Florence, Italy.
[Ti] Título:Perception of bronchoconstriction and bronchial hyper-responsiveness in asthma.
[So] Source:Clin Sci (Lond);98(6):681-7, 2000 Jun.
[Is] ISSN:0143-5221
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The inter-relationship between the perception of bronchoconstriction, bronchial hyper-responsiveness and temporal adaptation in asthma is still a matter of debate. In a total of 52 stable asthmatic patients, 32 without airway obstruction ¿forced expiratory volume in 1 s (FEV(1))/vital capacity (VC) 84.1% (S.D. 7.9%), and 20 with airway obstruction [FEV(1)/VC 60% (4%)], we assessed the perception of bronchoconstriction during methacholine inhalation by using: (i) the slope and intercept of the Borg and VAS (Visual Analog Scale) scores against the decrease in FEV(1), expressed as a percentage of the predicted value; and (ii) the Borg and VAS scores at a 20% decrease in FEV(1) from the lowest post-saline level (PB(20)). Bronchial hyper-responsiveness was assessed as the provocative concentration of methacholine causing a 20% fall in FEV(1) (PC(20)FEV(1)). The reduction in FEV(1) was significantly related to the Borg and VAS scores, with values for the group mean slope and intercept of this relationship of 0.13 (S.D. 0.08) and -1.1 (3.02) for Borg, and 1.5 (1.19) and -12.01 (35) for VAS. PB(20) was 3 (1.75) with Borg scores and 34.6 (20.5) with VAS scores. Compared with the subgroup without airway obstruction, the obstructed subgroup exhibited similar slopes, but lower Borg and VAS intercepts. For similar decreases in FEV(1) (5-20% decreases from the lowest post-saline values), the Borg and VAS scores were lower in the non-obstructed than in the obstructed subgroup. PC(20)FEV(1) was significantly related to both Borg PB(20) and VAS PB(20) when considering all patients. When assessing the subgroups, PC(20)FEV(1) was related to Borg PB(20) and VAS PB(20) in the non-obstructed subjects, but not in the obstructed subjects. In neither subgroup was the log of the cumulative dose related to the Borg and VAS scores at the end of the test. We conclude that, unlike in previous studies, the ability to perceive acute bronchoconstriction may be reduced as background airflow obstruction increases in asthma. Bronchial hyper-responsiveness did not play a major role in perceived breathlessness in patients without airway obstruction, and even less of a role in patients with obstruction. The cumulative dose of agonist did not appear to influence the perception of bronchoconstriction.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hiper-Reatividade Brônquica/psicologia
Dispneia/psicologia
Percepção/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Obstrução das Vias Respiratórias/etiologia
Obstrução das Vias Respiratórias/fisiopatologia
Asma/complicações
Hiper-Reatividade Brônquica/etiologia
Hiper-Reatividade Brônquica/fisiopatologia
Testes de Provocação Brônquica
Broncoconstritores
Criança
Dispneia/etiologia
Dispneia/fisiopatologia
Feminino
Volume Expiratório Forçado
Seres Humanos
Masculino
Compostos de Metacolina
Meia-Idade
Capacidade Vital
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bronchoconstrictor Agents); 0 (Methacholine Compounds)
[Em] Mês de entrada:0007
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000518
[St] Status:MEDLINE


  8 / 2397 MEDLINE  
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[PMID]:10719299
[Au] Autor:Zimmerman B; Silverman FS; Tarlo SM; Chapman KR; Kubay JM; Urch B
[Ad] Endereço:Gage Occupational & Environmental Health Unit, St Michael's Hospital, and the Asthma Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Induced sputum: comparison of postinfectious cough with allergic asthma in children.
[So] Source:J Allergy Clin Immunol;105(3):495-9, 2000 Mar.
[Is] ISSN:0091-6749
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cough persisting after a respiratory infection is common in children and is often managed as asthma. However, little is known about the pathophysiologic mechanisms of such cough and how it compares with asthma. OBJECTIVE: We used the technique of induced sputum to examine the inflammatory index values associated with persistent cough or allergic asthma in children. We hypothesized that the sputum from children with persistent postinfectious cough would differ from that of children with allergic asthma in that the former would lack eosinophils compared with the latter. STUDY DESIGN: Sputum production was induced with hypertonic saline solution in 34 children: 12 with cough persisting for 1 month or more after an apparent respiratory tract infection, not treated with corticosteroid; 11 with untreated atopic asthma, not using inhaled corticosteroid; and 11 with treated atopic asthma using inhaled corticosteroid. RESULTS: The percentage of eosinophils in the sputum of children with cough was significantly lower than in the sputum of children with untreated allergic asthma (median 0.5% vs 14.5%, P <.0001). Similarly, the percentage of eosinophils in the sputum of children with asthma treated with inhaled steroids was significantly lower compared with untreated asthmatic children (1.5% vs 14.5%, P <.0001). The peripheral blood eosinophils, serum eosinophil cationic protein, and nasal percent eosinophils of the patients with cough were also significantly lower than those from patients with untreated asthma. Methacholine challenge in 6 of the 11 cough patients tested showed mild-to-moderate hyperresponsiveness, whereas the other 5 had a negative methacholine challenge. CONCLUSIONS: Children with persistent postinfectious cough do not have airway eosinophilia typical of untreated asthma. Despite the absence of eosinophilic inflammation, some of the patients with chronic cough had reactive airways. These results suggest that postinfectious cough in children has different pathophysiologic features than allergic asthma and probably represents a different disease.
[Mh] Termos MeSH primário: Ribonucleases
Escarro/citologia
[Mh] Termos MeSH secundário: Asma/complicações
Proteínas Sanguíneas/análise
Criança
Pré-Escolar
Tosse/etiologia
Proteínas Granulares de Eosinófilos
Eosinófilos/citologia
Feminino
Seres Humanos
Infecção/complicações
Mediadores da Inflamação/análise
Interleucina-8/análise
Contagem de Leucócitos
Masculino
Compostos de Metacolina/farmacologia
Escarro/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Eosinophil Granule Proteins); 0 (Inflammation Mediators); 0 (Interleukin-8); 0 (Methacholine Compounds); EC 3.1.- (Ribonucleases)
[Em] Mês de entrada:0004
[Cu] Atualização por classe:140728
[Lr] Data última revisão:
140728
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:000317
[St] Status:MEDLINE


  9 / 2397 MEDLINE  
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[PMID]:10619791
[Au] Autor:Louis R; Lau LC; Bron AO; Roldaan AC; Radermecker M; Djukanovic R
[Ad] Endereço:University of Southampton, Southampton, United Kingdom.
[Ti] Título:The relationship between airways inflammation and asthma severity.
[So] Source:Am J Respir Crit Care Med;161(1):9-16, 2000 Jan.
[Is] ISSN:1073-449X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to investigate the relationship between airways inflammation and disease severity, and improve the understanding of persistent asthma, 74 asthmatics, with disease severity ranging from intermittent, to mild to moderate and severe persistent (classified according to the Global Initiative for Asthma [GINA] guidelines), and 22 nonatopic control subjects were studied using the method of induced sputum. Sputum was analyzed for total and differential cell counts concentrations of albumin, and levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase, inflammatory mediators reflecting eosinophil, neutrophil, and mast cell activation. Asthma severity (assessed by FEV(1), peak expiratory flow [PEF] variability, and daily symptom scores) and methacholine airways responsiveness were related to sputum eosinophilia and ECP. In addition, sputum neutrophilia and MPO levels correlated, albeit weakly, with PEF variability and symptom scores, respectively. Tryptase concentrations were raised in mild to moderate asthmatics. Albumin concentrations were significantly raised across the spectrum of asthma severity and correlated with those of tryptase and ECP. Despite treatment with either high doses of inhaled corticosteroids or oral corticosteroids, prominent eosinophilic inflammation with raised ECP was noted. This study points to persistent, disease severity-related airways inflammation in asthma, involving eosinophils, mast cells, and neutrophils, which is evident despite treatment with corticosteroids.
[Mh] Termos MeSH primário: Asma/fisiopatologia
Hiper-Reatividade Brônquica/fisiopatologia
Ribonucleases
[Mh] Termos MeSH secundário: Adulto
Albuminas/metabolismo
Asma/tratamento farmacológico
Asma/metabolismo
Biomarcadores
Proteínas Sanguíneas/metabolismo
Hiper-Reatividade Brônquica/tratamento farmacológico
Hiper-Reatividade Brônquica/metabolismo
Quimases
Proteínas Granulares de Eosinófilos
Eosinófilos/metabolismo
Eosinófilos/patologia
Feminino
Glucocorticoides/uso terapêutico
Seres Humanos
Masculino
Mastócitos/enzimologia
Mastócitos/patologia
Compostos de Metacolina
Neutrófilos/enzimologia
Neutrófilos/patologia
Peroxidase/metabolismo
Testes de Função Respiratória
Serina Endopeptidases/metabolismo
Índice de Gravidade de Doença
Escarro/citologia
Escarro/metabolismo
Triptases
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Albumins); 0 (Biomarkers); 0 (Blood Proteins); 0 (Eosinophil Granule Proteins); 0 (Glucocorticoids); 0 (Methacholine Compounds); EC 1.11.1.7 (Peroxidase); EC 3.1.- (Ribonucleases); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.- (chymase 2); EC 3.4.21.39 (Chymases); EC 3.4.21.59 (Tryptases)
[Em] Mês de entrada:0002
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:000105
[St] Status:MEDLINE


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Fotocópia
[PMID]:9788693
[Au] Autor:Acero S; Tabar AI; Alvarez MJ; Garcia BE; Olaguibel JM; Moneo I
[Ad] Endereço:Seccion Alergología, Hospital Virgen del Camino, Pamplona, Spain.
[Ti] Título:Occupational asthma and food allergy due to carmine.
[So] Source:Allergy;53(9):897-901, 1998 Sep.
[Is] ISSN:0105-4538
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Carmine (E120), a natural red dye extracted from the dried females of the insect Dactylopius coccus var. Costa (cochineal), has been reported to cause hypersensitivity reactions. We report a case of occupational asthma and food allergy due to carmine in a worker not engaged in dye manufacturing. A 35-year-old nonatopic man, who had worked for 4 years in a spice warehouse, reported asthma and rhinoconjunctivitis for 5 months, related to carmine handling in his work. Two weeks before the visit, he reported one similar episode after the ingestion of a red-colored sweet containing carmine. Peak flow showed drops higher than 25% related to carmine exposure. Prick tests with the cochineal insect and carmine were positive, but negative to common aeroallergens, several mites, foods, and spices. The methacholine test was positive. Specific bronchial challenge test with a cochineal extract was positive with a dual pattern (20% and 24% fall in FEV1). Double-blind oral challenge with E120 was positive. The patient's sera contained specific IgE for various high-molecular-weight proteins from the cochineal extract, as shown by immunoblotting. Carmine proteins can induce IgE-mediated food allergy and occupational asthma in workers using products where its presence could be easily overlooked, as well as in dye manufacture workers.
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Asma/etiologia
Carmim/efeitos adversos
Corantes/efeitos adversos
Hipersensibilidade Alimentar/etiologia
Doenças Profissionais/etiologia
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Alérgenos/imunologia
Asma/diagnóstico
Asma/imunologia
Testes de Provocação Brônquica
Conjuntivite Alérgica/etiologia
Eletroforese em Gel de Poliacrilamida
Hipersensibilidade Alimentar/diagnóstico
Hipersensibilidade Alimentar/imunologia
Seres Humanos
Imunoglobulina E/análise
Masculino
Compostos de Metacolina
Doenças Profissionais/diagnóstico
Doenças Profissionais/imunologia
Pico do Fluxo Expiratório
Rinite/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Coloring Agents); 0 (Methacholine Compounds); 37341-29-0 (Immunoglobulin E); CID8Z8N95N (Carmine)
[Em] Mês de entrada:9812
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:981027
[St] Status:MEDLINE



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