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[PMID]:28456841
[Au] Autor:Blanco-Gandía MC; Aracil-Fernández A; Montagud-Romero S; Aguilar MA; Manzanares J; Miñarro J; Rodríguez-Arias M
[Ad] Endereço:Departamento de Psicobiología, Facultad de Psicología, Unidad de Investigación Psicobiología de las Drogodependencias, , Universitat de València, Avda. Blasco Ibáñez, 21, 46010, Valencia, Spain.
[Ti] Título:Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.
[So] Source:Psychopharmacology (Berl);234(15):2337-2352, 2017 Aug.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Preclinical studies report that free access to a high-fat diet (HFD) alters the response to psychostimulants. OBJECTIVES: The aim of the present study was to examine how HFD exposure during adolescence modifies cocaine effects. Gene expression of CB1 and mu-opioid receptors (MOr) in the nucleus accumbens (N Acc) and prefrontal cortex (PFC) and ghrelin receptor (GHSR) in the ventral tegmental area (VTA) were assessed. METHODS: Mice were allowed continuous access to fat from PND 29, and the locomotor (10 mg/kg) and reinforcing effects of cocaine (1 and 6 mg/kg) on conditioned place preference (CPP) were evaluated on PND 69. Another group of mice was exposed to a standard diet until the day of post-conditioning, on which free access to the HFD began. RESULTS: HFD induced an increase of MOr gene expression in the N Acc, but decreased CB1 receptor in the N Acc and PFC. After fat withdrawal, the reduction of CB1 receptor in the N Acc was maintained. Gene expression of GHSR in the VTA decreased during the HFD and increased after withdrawal. Following fat discontinuation, mice exhibited increased anxiety, augmented locomotor response to cocaine, and developed CPP for 1 mg/kg cocaine. HFD reduced the number of sessions required to extinguish the preference and decreased sensitivity to drug priming-induced reinstatement. CONCLUSION: Our results suggest that consumption of a HFD during adolescence induces neurobiochemical changes that increased sensitivity to cocaine when fat is withdrawn, acting as an alternative reward.
[Mh] Termos MeSH primário: Cocaína/farmacologia
Dieta Hiperlipídica/psicologia
Dieta Hiperlipídica/tendências
Receptor CB1 de Canabinoide/biossíntese
Receptor CB1 de Canabinoide/genética
Recompensa
[Mh] Termos MeSH secundário: Animais
Condicionamento Clássico/efeitos dos fármacos
Condicionamento Clássico/fisiologia
Expressão Gênica
Masculino
Camundongos
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Córtex Pré-Frontal/efeitos dos fármacos
Córtex Pré-Frontal/metabolismo
Receptores de Grelina/metabolismo
Receptores Opioides mu/metabolismo
Reforço (Psicologia)
Área Tegmentar Ventral/efeitos dos fármacos
Área Tegmentar Ventral/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Cannabinoid, CB1); 0 (Receptors, Ghrelin); 0 (Receptors, Opioid, mu); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-017-4630-9


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[PMID]:28451642
[Au] Autor:Moschak TM; Carelli RM
[Ad] Endereço:Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC 27599.
[Ti] Título:Impulsive Rats Exhibit Blunted Dopamine Release Dynamics during a Delay Discounting Task Independent of Cocaine History.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The inability to wait for a large, delayed reward when faced with a small, immediate one, known as delay discounting, has been implicated in a number of disorders including substance abuse. Individual differences in impulsivity on the delay discounting task are reflected in differences in neural function, including in the nucleus accumbens (NAc) core. We examined the role of a history of cocaine self-administration, as well as individual differences in impulsivity, on rapid dopamine (DA) release dynamics in the NAc core. Rats with a history of cocaine or water/saline self-administration were tested on delay discounting while being simultaneously assayed for rapid DA release using electrochemical methods. In controls, we found that cue DA release was modulated by reward delay and magnitude, consistent with prior reports. A history of cocaine had no effect on either delay discounting or DA release dynamics. Nonetheless, independent of drug history, individual differences in impulsivity were related to DA release in the NAc core. First, high impulsive animals exhibited dampened cue DA release during the delay discounting task. Second, reward delay and magnitude in high impulsive animals failed to robustly modulate changes in cue DA release. Importantly, these two DAergic mechanisms were uncorrelated with each other and, together, accounted for a high degree of variance in impulsive behavior. Collectively, these findings demonstrate two distinct mechanisms by which rapid DA signaling may influence impulsivity, and illustrate the importance of NAc core DA release dynamics in impulsive behavior.
[Mh] Termos MeSH primário: Cocaína/administração & dosagem
Desvalorização pelo Atraso/efeitos dos fármacos
Dopamina/metabolismo
Comportamento Impulsivo
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
[Mh] Termos MeSH secundário: Animais
Condicionamento Operante
Masculino
Ratos Long-Evans
Recompensa
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
I5Y540LHVR (Cocaine); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29339724
[Au] Autor:Calipari ES; Godino A; Peck EG; Salery M; Mervosh NL; Landry JA; Russo SJ; Hurd YL; Nestler EJ; Kiraly DD
[Ad] Endereço:Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[Ti] Título:Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine.
[So] Source:Nat Commun;9(1):9, 2018 01 16.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex. In addition, G-CSF injections potentiate cocaine place preference and enhance motivation to self-administer cocaine, while not affecting responses to natural rewards. Infusion of G-CSF neutralizing antibody into NAc blocks the ability of G-CSF to modulate cocaine's behavioral effects, providing a direct link between central G-CSF action in NAc and cocaine reward. These results demonstrate that manipulating G-CSF is sufficient to alter the motivation for cocaine, but not natural rewards, providing a pharmacotherapeutic avenue to manipulate addictive behaviors without abuse potential.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico
Cocaína/farmacologia
Fator Estimulador de Colônias de Granulócitos/metabolismo
Plasticidade Neuronal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Comportamento Aditivo/tratamento farmacológico
Comportamento Aditivo/fisiopatologia
Cocaína/administração & dosagem
Transtornos Relacionados ao Uso de Cocaína/fisiopatologia
Condicionamento Operante
Fator Estimulador de Colônias de Granulócitos/administração & dosagem
Fator Estimulador de Colônias de Granulócitos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Ratos
Ratos Sprague-Dawley
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
143011-72-7 (Granulocyte Colony-Stimulating Factor); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-01881-x


  4 / 22156 MEDLINE  
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[PMID]:29393308
[Au] Autor:Farrell CM; Cucu DF
[Ad] Endereço:Resident Physician, Northwestern University.
[Ti] Título:Cocaine-Related Acute Spinal Cord Infarction.
[So] Source:R I Med J (2013);101(1):28-29, 2018 Feb 02.
[Is] ISSN:2327-2228
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a rare case of anterior spinal artery syndrome in the setting of acute cocaine use. A 31-year-old man presented to the hospital unarousable with leukocytosis and a positive toxicology screen for opioids, cocaine, benzodiazepines and cannabis. He was placed on intravenous naloxone. As the patient regained consciousness, he was found to have paraplegia, sensory loss below the level of T5, and urinary retention. MRI findings showed a signal intensity abnormality from the level of T1-4, highly suggestive of an acute ischemic spinal cord infarct. [Full article available at http://rimed.org/rimedicaljournal-2018-02.asp].
[Mh] Termos MeSH primário: Síndrome da Artéria Espinal Anterior/induzido quimicamente
Transtornos Relacionados ao Uso de Cocaína/complicações
Cocaína/toxicidade
Drogas Ilícitas/toxicidade
[Mh] Termos MeSH secundário: Adulto
Síndrome da Artéria Espinal Anterior/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


  5 / 22156 MEDLINE  
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[PMID]:29061385
[Au] Autor:Hofford RS; Prendergast MA; Bardo MT
[Ad] Endereço:Department of Psychology, University of Kentucky, Lexington, KY, 40536, USA. Electronic address: rebecca.hofford@uky.edu.
[Ti] Título:Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment.
[So] Source:Behav Brain Res;338:143-152, 2018 Feb 15.
[Is] ISSN:1872-7549
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration. The current study applied modified SPS (modSPS; two hours restraint immediately followed by cold swim stress) to rats raised in an isolation condition (Iso), enrichment condition (Enr), or standard condition (Std) to measure changes in cocaine self-administration and HPA markers. Regardless of rearing condition, rats exposed to modSPS had greater corticosterone (CORT) release and reduced cocaine self-administration during initial acquisition compared to non-stressed controls. In addition, during initial acquisition, rats that received both Iso rearing and modSPS showed a more rapid increase in cocaine self-administration across sessions compared to Enr and Std rats exposed to modSPS. Following initial acquisition, a dose response analysis showed that Iso rats were overall most sensitive to changes in cocaine unit dose; however, modSPS had no effect on the cocaine dose response curve. Further, there was no effect of either modSPS or differential rearing on expression of glucocorticoid receptor (GR) in hypothalamus, medial prefrontal cortex, amygdala, or nucleus accumbens. By using modSPS in combination with Iso housing, this study identified unique contributions of each stressor to acquisition of cocaine self-administration.
[Mh] Termos MeSH primário: Cocaína/administração & dosagem
Corticosterona/sangue
Inibidores da Captação de Dopamina/administração & dosagem
Receptores de Glucocorticoides/metabolismo
Isolamento Social
Estresse Psicológico/sangue
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/efeitos dos fármacos
Tonsila do Cerebelo/metabolismo
Animais
Abrigo para Animais
Masculino
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Córtex Pré-Frontal/efeitos dos fármacos
Córtex Pré-Frontal/metabolismo
Ratos
Ratos Sprague-Dawley
Restrição Física
Autoadministração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dopamine Uptake Inhibitors); 0 (Receptors, Glucocorticoid); I5Y540LHVR (Cocaine); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE


  6 / 22156 MEDLINE  
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[PMID]:28466092
[Au] Autor:Montagud-Romero S; Nuñez C; Blanco-Gandia MC; Martínez-Laorden E; Aguilar MA; Navarro-Zaragoza J; Almela P; Milanés MV; Laorden ML; Miñarro J; Rodríguez-Arias M
[Ad] Endereço:Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez, 21, 46010, Valencia, Spain.
[Ti] Título:Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system.
[So] Source:Psychopharmacology (Berl);234(13):2063-2075, 2017 Jul.
[Is] ISSN:1432-2072
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Repeated social defeat (RSD) increases the rewarding effects of cocaine in adolescent and adult rodents. OBJECTIVE: The aim of the present study was to compare the long-term effects of RSD on the conditioned rewarding effects of cocaine and levels of the transcription factors Pitx3 and Nurr1 in the ventral tegmental area (VTA), the dopamine transporter (DAT), the D2 dopamine receptor (D2DR) and precursor of brain-derived neurotrophic factor (proBDNF) signaling pathways, and the tropomyosin-related kinase B (TrkB) receptor in the nucleus accumbens (NAc) in adult and adolescent mice. METHODS: Male adolescent and young adult OF1 mice were exposed to four episodes of social defeat and were conditioned 3 weeks later with 1 mg/kg of cocaine. In a second set of mice, the expressions of the abovementioned dopaminergic and proBDNF and TrkB receptor were measured in VTA and NAc, respectively. RESULTS: Adolescent mice experienced social defeats less intensely than their adult counterparts and produced lower levels of corticosterone. However, both adult and adolescent defeated mice developed conditioned place preference for the compartment associated with this low dose of cocaine. Furthermore, only adolescent defeated mice displayed diminished levels of the transcription factors Pitx3 in the VTA, without changes in the expression of DAT and D2DR in the NAc. In addition, stressed adult mice showed a decreased expression of proBDNF and the TrkB receptor, while stressed adolescent mice exhibited increased expression of latter without changes in the former. CONCLUSION: Our findings suggest that dopaminergic pathways and proBDNF signaling and TrkB receptors play different roles in social defeat-stressed mice exposed to cocaine.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/fisiologia
Encéfalo/metabolismo
Cocaína/farmacologia
Condicionamento Clássico/efeitos dos fármacos
Corticosterona/metabolismo
Glicoproteínas de Membrana/metabolismo
Núcleo Accumbens/efeitos dos fármacos
Precursores de Proteínas/fisiologia
Receptor trkB/metabolismo
Receptores de Dopamina D2/metabolismo
Fatores de Transcrição/metabolismo
Área Tegmentar Ventral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Encéfalo/fisiologia
Fator Neurotrófico Derivado do Encéfalo/química
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Condicionamento Clássico/fisiologia
Corticosterona/química
Dopamina/metabolismo
Masculino
Glicoproteínas de Membrana/química
Camundongos
Precursores de Proteínas/química
Receptor trkB/química
Receptores de Dopamina D2/química
Recompensa
Estresse Psicológico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (DRD2 protein, human); 0 (Membrane Glycoproteins); 0 (Protein Precursors); 0 (Receptors, Dopamine D2); 0 (Transcription Factors); 0 (brain-derived neurotrophic factor precursor); EC 2.7.10.1 (Receptor, trkB); EC 2.7.10.1 (tropomyosin-related kinase-B, human); I5Y540LHVR (Cocaine); VTD58H1Z2X (Dopamine); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s00213-017-4612-y


  7 / 22156 MEDLINE  
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[PMID]:28993024
[Au] Autor:Parolini M; Bini L; Magni S; Rizzo A; Ghilardi A; Landi C; Armini A; Del Giacco L; Binelli A
[Ad] Endereço:Department of Environmental Science and Policy, University of Milan, via Celoria 2, I-20133 Milano, Italy. Electronic address: marco.parolini@unimi.it.
[Ti] Título:Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos.
[So] Source:Environ Pollut;232:603-614, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Illicit drugs have been identified as emerging aquatic pollutants because of their widespread presence in freshwaters and potential toxicity towards aquatic organisms. Among illicit drug residues, cocaine (COC) and its main metabolites, namely benzoylecgonine (BE) and ecgonine methyl ester (EME), are commonly detected in freshwaters worldwide at concentration that can induce diverse adverse effects to non-target organisms. However, the information of toxicity and mechanisms of action (MoA) of these drugs, mainly of COC metabolites, to aquatic species is still fragmentary and inadequate. Thus, this study was aimed at investigating the toxicity of two concentrations (0.3 and 1.0 µg/L) of COC, BE and EME similar to those found in aquatic ecosystems on zebrafish (Danio rerio) embryos at 96 h post fertilization through a functional proteomics approach. Exposure to COC and both its metabolites significantly altered the protein profile of zebrafish embryos, modulating the expression of diverse proteins belonging to different functional classes, including cytoskeleton, eye constituents, lipid transport, lipid and energy metabolism, and stress response. Expression of vitellogenins and crystallins was modulated by COC and both its main metabolites, while only BE and EME altered proteins related to lipid and energy metabolism, as well as to oxidative stress response. Our data confirmed the potential toxicity of low concentrations of COC, BE and EME, and helped to shed light on their MoA on an aquatic vertebrate during early developmental period.
[Mh] Termos MeSH primário: Cocaína/toxicidade
Embrião não Mamífero/efeitos dos fármacos
Drogas Ilícitas/toxicidade
Proteínas de Peixe-Zebra/metabolismo
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Cocaína/análogos & derivados
Cocaína/metabolismo
Embrião não Mamífero/fisiologia
Água Doce
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Street Drugs); 0 (Zebrafish Proteins); 5353I8I6YS (benzoylecgonine); I5Y540LHVR (Cocaine); Y35FJB3QBJ (ecgonine methyl ester)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE


  8 / 22156 MEDLINE  
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[PMID]:28928019
[Au] Autor:Parolini M; De Felice B; Ferrario C; Salgueiro-González N; Castiglioni S; Finizio A; Tremolada P
[Ad] Endereço:Department of Environmental Science and Policy, University of Milan, via Celoria 2, I-20133 Milan, Italy. Electronic address: marco.parolini@unimi.it.
[Ti] Título:Benzoylecgonine exposure induced oxidative stress and altered swimming behavior and reproduction in Daphnia magna.
[So] Source:Environ Pollut;232:236-244, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several monitoring studies have shown that benzoylecgonine (BE) is the main illicit drug residue commonly measured in the aquatic system worldwide. Few studies have investigated the potential toxicity of this molecule towards invertebrate and vertebrate aquatic non-target organisms focusing on effects at low levels of the biological organization, but no one has assessed the consequences at higher ones. Thus, the present study was aimed at investigating the toxicity of a 48-h exposure to two concentrations of BE, similar to those found in aquatic ecosystems (0.5 µg/L and 1.0 µg/L), on the cladoceran Daphnia magna at different levels of the ecological hierarchy. We relied on a multi-level approach focusing on the effects at biochemical/biomolecular (biomarkers), individual (swimming activity) and population (reproduction) levels. We measured the amount of reactive oxygen species and of the activity of antioxidant (SOD, CAT, and GPx) and detoxifying (GST) enzymes to assess if BE exposure can alter the oxidative status of D. magna specimens, while the lipid peroxidation (TBARS) was measured as a marker of oxidative damage. Moreover, we also measured the acetylcholinesterase (AChE) activity because it is strictly related to behavioral changes in aquatic organisms. Changes in swimming behavior were investigated by a video tracking analysis, while the consequences on reproduction were assessed by a chronic toxicity test. Our results showed that BE concentrations similar to those found in aquatic ecosystems induced oxidative stress and inhibited AChE activity, affecting swimming behavior and the reproduction of Daphnia magna individuals.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Cocaína/análogos & derivados
Daphnia/fisiologia
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Biomarcadores/metabolismo
Cocaína/toxicidade
Daphnia/efeitos dos fármacos
Peroxidação de Lipídeos
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio
Reprodução/efeitos dos fármacos
Natação
Testes de Toxicidade Crônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Reactive Oxygen Species); 0 (Water Pollutants, Chemical); 5353I8I6YS (benzoylecgonine); I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


  9 / 22156 MEDLINE  
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[PMID]:28455125
[Au] Autor:Amaning-Kwarteng AO; Asif-Malik A; Pei Y; Canales JJ
[Ad] Endereço:Department of Neuroscience, Psychology and Behaviour, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom.
[Ti] Título:Relapse to cocaine seeking in an invertebrate.
[So] Source:Pharmacol Biochem Behav;157:41-46, 2017 Jun.
[Is] ISSN:1873-5177
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Addiction is characterised by cycles of compulsive drug taking, periods of abstinence and episodes of relapse. The extinction/reinstatement paradigm has been extensively used in rodents to model human relapse and explore underlying mechanisms and therapeutics. However, relapse to drug seeking behaviour has not been previously demonstrated in invertebrates. Here, we used a cocaine conditioned place preference (CPP) paradigm in the flatworm, planarian, followed by extinction and reinstatement of drug seeking. Once baseline preference was established for one of two distinctly textured environments (i.e. compartments with a coarse or smooth surface), planarian received pairings of cocaine (5µM) in the non-preferred, and vehicle in the most preferred, environment, and were tested for conditioning thereafter. Cocaine produced robust CPP, measured as a significant increase in the time spent in the cocaine-paired compartment. Subsequently, planarian underwent extinction training, reverting back to their original preference within three sessions. Brief exposure to cocaine (5µM) or methamphetamine (5µM) reinstated cocaine-seeking behaviour. By contrast, the high affinity dopamine transporter inhibitor, (N-(n-butyl)-3α-[bis (4-fluorophenyl) methoxy]-tropane) (JHW007), which in rodents exhibits a neurochemical and behavioural profile distinct from cocaine, was ineffective. The present findings demonstrate for the first time reinstatement of extinguished cocaine seeking in an invertebrate model and suggest that the long-term adaptations underlying drug conditioning and relapse are highly conserved through evolution.
[Mh] Termos MeSH primário: Cocaína/farmacologia
Condicionamento Operante/efeitos dos fármacos
Comportamento de Procura de Droga/efeitos dos fármacos
Extinção Psicológica/efeitos dos fármacos
Locomoção/efeitos dos fármacos
Reforço (Psicologia)
[Mh] Termos MeSH secundário: Animais
Comportamento Aditivo/psicologia
Condicionamento Operante/fisiologia
Comportamento de Procura de Droga/fisiologia
Extinção Psicológica/fisiologia
Invertebrados
Locomoção/fisiologia
Planárias
Recidiva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
I5Y540LHVR (Cocaine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29176843
[Au] Autor:Javadi-Paydar M; Roscoe RF; Denton AR; Mactutus CF; Booze RM
[Ad] Endereço:Behavioral Neuroscience Laboratory, Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America.
[Ti] Título:HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum.
[So] Source:PLoS One;12(11):e0188404, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HIV-1 and addictive drugs, such as cocaine (COC), may act in combination to produce serious neurological complications. In the present experiments, striatal brain slices from HIV-1 transgenic (Tg) and F344 control female rats were studied. First, we examined dopamine (DA) reuptake in control, HIV-1, COC-treated (5µM) and HIV-1+COC-treated, striatal slices using fast scan cyclic voltammetry. COC-treated striatal slices from F344 control animals significantly increased DA reuptake time (T80), relative to untreated control slices. In contrast, in HIV-1 Tg striatal slices, DA reuptake time was extended by HIV-1, which was not further altered by COC treatment. Second, analysis of medium spiny neuronal populations from striatal brain slices found that controls treated with cocaine displayed increases in spine length, whereas cocaine treated HIV-1 slices displayed decreased spine length. Taken together, the current study provides evidence for dysfunction of the dopamine transporter (DAT) in mediating DA reuptake in HIV-1 Tg rats and limited responses to acute COC exposure. Collectively, dysfunction of the DAT reuptake and altered dendritic spine morphology of the MSNs, suggest a functional disruption of the dopamine system within the HIV-1 Tg rat.
[Mh] Termos MeSH primário: Cocaína/farmacologia
Corpo Estriado/citologia
Dopamina/metabolismo
HIV-1/fisiologia
Neurônios/metabolismo
[Mh] Termos MeSH secundário: Animais
Espinhas Dendríticas/efeitos dos fármacos
Espinhas Dendríticas/metabolismo
Feminino
Neurônios/efeitos dos fármacos
Núcleo Accumbens/efeitos dos fármacos
Núcleo Accumbens/metabolismo
Ratos Endogâmicos F344
Ratos Transgênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
I5Y540LHVR (Cocaine); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188404



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