[PMID]: | 28273279 |
[Au] Autor: | Mardini V; Rohde LA; Ceresér KM; Gubert CM; Silva EGD; Xavier F; Parcianello R; Röhsig LM; Pechansky F; Szobot CM |
[Ad] Endereço: | Serviço de Psiquiatria da Infância e Adolescência (SPIA), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. |
[Ti] Título: | TBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy: a comparative study. |
[So] Source: | Rev Bras Psiquiatr;39(3):263-266, 2017 Jul-Sep. |
[Is] ISSN: | 1809-452X |
[Cp] País de publicação: | Brazil |
[La] Idioma: | eng |
[Ab] Resumo: | Objectives:: To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and non-exposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery. Methods:: This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed. Results:: After adjusting for potential confounders, adjusted mean BDNF was significantly higher in EN (3.86 ng/mL, 95% confidence interval [95%CI] 2.29-5.43) than in NEN (0.85 ng/mL, 95%CI 0.47-1.23; p < 0.001; Cohen effect size: 1.12), and significantly lower in crack/cocaine mothers than in control mothers (4.03 ng/mL, 95%CI 2.87-5.18 vs. 6.67 ng/mL, 95%CI 5.60-7.74; p = 0.006). The adjusted mean TBARS level was significantly lower in EN (63.97 µM MDA, 95%CI 39.43-88.50) than NEN (177.04 µM MDA, 95%CI 140.93-213.14; p < 0.001; effect size = 0.84), with no difference between mother groups (p = 0.86). Conclusions:: The changes in TBARS levels observed in EN suggest that fetuses exposed to cocaine mobilize endogenous antioxidant routes since very early stages of development. The increase in BDNF levels in EN might indicate changes in fetal development, whereas the changes in BDNF levels in mothers provide evidence of the complex metabolic processes involved in drug use during pregnancy. |
[Mh] Termos MeSH primário: |
Fator Neurotrófico Derivado do Encéfalo/sangue Cocaína Crack/farmacologia Sangue Fetal/química Substâncias Reativas com Ácido Tiobarbitúrico/análise
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[Mh] Termos MeSH secundário: |
Adolescente Adulto Transtornos Relacionados ao Uso de Cocaína/sangue Estudos Transversais Feminino Seres Humanos Recém-Nascido Meia-Idade Oxirredução/efeitos dos fármacos Período Pós-Parto/sangue Gravidez Adulto Jovem
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[Pt] Tipo de publicação: | COMPARATIVE STUDY; JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Brain-Derived Neurotrophic Factor); 0 (Crack Cocaine); 0 (Thiobarbituric Acid Reactive Substances) |
[Em] Mês de entrada: | 1711 |
[Cu] Atualização por classe: | 171106 |
[Lr] Data última revisão:
| 171106 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170309 |
[St] Status: | MEDLINE |
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