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Pesquisa : D02.145.074.722.822.775 [Categoria DeCS]
Referências encontradas : 6176 [refinar]
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[PMID]:29260547
[Au] Autor:Hong SM; Soe KH; Lee TH; Kim IS; Lee YM; Lim BO
[Ad] Endereço:BK21PLUS Glocal Education Program of Nutraceuticals Development, Konkuk University , Chungju-si, Chungcheongbuk-do 27478, Republic of Korea.
[Ti] Título:Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model.
[So] Source:J Agric Food Chem;66(1):99-107, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the preventive effects of highbush blueberry (Vaccinium corymbosum L.) vinegar (BV) on cognitive functions in a scopolamine (Sco)-induced amnesia model in mice. In this study, Sco (1 mg/kg, intraperitoneal injection) was used to induce amnesia. ICR mice were orally administered donepezil (5 mg/kg), blueberry extract (120 mg/kg), and BV (120 mg/kg) for 7 days. After inducing cognitive impairment by Sco, a behavioral assessment using behavior tests (i.e., Y-maze and passive avoidance tests) was performed. The BV group showed significantly restored cognitive function in the behavioral tests. BV facilitated cholinergic activity by inhibiting acetylcholinesterase activity, and enhanced antioxidant enzyme activity. Furthermore, BV was found to be rehabilitated in the cornu ammonis 1 neurons of hippocampus. In our study, we demonstrated that the memory protection conferred by BV was linked to activation of brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein (CREB)/serine-threonine kinase (AKT) signaling.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Mirtilos Azuis (Planta)/química
Cognição/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Acetilcolinesterase/metabolismo
Amnésia/induzido quimicamente
Animais
Aprendizagem da Esquiva/efeitos dos fármacos
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Modelos Animais de Doenças
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Aprendizagem em Labirinto
Camundongos Endogâmicos ICR
Extratos Vegetais/química
Hidrobrometo de Escopolamina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide); EC 3.1.1.7 (Acetylcholinesterase); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b03965


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[PMID]:29405075
[Au] Autor:Zhu J; Yang H; Chen Y; Lin H; Li Q; Mo J; Bian Y; Pei Y; Sun H
[Ad] Endereço:a Department of Medicinal Chemistry , China Pharmaceutical University , Nanjing , China.
[Ti] Título:Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
[So] Source:J Enzyme Inhib Med Chem;33(1):496-506, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The cholinergic hypothesis has long been a "polar star" in drug discovery for Alzheimer's disease (AD), resulting in many small molecules and biological drug candidates. Most of the drugs marketed for AD are cholinergic. Herein, we report our efforts in the discovery of cholinesterases inhibitors (ChEIs) as multi-target-directed ligands. A series of tacrine-ferulic acid hybrids have been designed and synthesised. All these compounds showed potent acetyl-(AChE) and butyryl cholinesterase(BuChE) inhibition. Among them, the optimal compound 10g, was the most potent inhibitor against AChE (electrophorus electricus (eeAChE) half maximal inhibitory concentration (IC ) = 37.02 nM), it was also a strong inhibitor against BuChE (equine serum (eqBuChE) IC = 101.40 nM). Besides, it inhibited amyloid ß-protein self-aggregation by 65.49% at 25 µM. In subsequent in vivo scopolamine-induced AD models, compound 10g obviously ameliorated the cognition impairment and showed preliminary safety in hepatotoxicity evaluation. These data suggest compound 10g as a promising multifunctional agent in the drug discovery process against AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Inibidores da Colinesterase/síntese química
Inibidores da Colinesterase/farmacologia
Ácidos Cumáricos/farmacologia
Simulação de Acoplamento Molecular
Tacrina/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Doença de Alzheimer/induzido quimicamente
Peptídeos beta-Amiloides/antagonistas & inibidores
Animais
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/química
Ácidos Cumáricos/química
Relação Dose-Resposta a Droga
Electrophorus
Cavalos
Seres Humanos
Ligantes
Masculino
Camundongos
Camundongos Endogâmicos ICR
Estrutura Molecular
Fragmentos de Peptídeos/antagonistas & inibidores
Agregados Proteicos/efeitos dos fármacos
Hidrobrometo de Escopolamina
Relação Estrutura-Atividade
Tacrina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Cholinesterase Inhibitors); 0 (Coumaric Acids); 0 (Ligands); 0 (Peptide Fragments); 0 (Protein Aggregates); 0 (amyloid beta-protein (1-42)); 451IFR0GXB (Scopolamine Hydrobromide); 4VX7YNB537 (Tacrine); AVM951ZWST (ferulic acid); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1430691


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[PMID]:28449397
[Au] Autor:Baghel MS; Thakur MK
[Ad] Endereço:Department of Zoology, Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Banaras Hindu University, Varanasi, 221005, India.
[Ti] Título:Differential proteome profiling in the hippocampus of amnesic mice.
[So] Source:Hippocampus;27(8):845-859, 2017 Aug.
[Is] ISSN:1098-1063
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Amnesia or memory loss is associated with brain aging and several neurodegenerative pathologies including Alzheimer's disease (AD). This can be induced by a cholinergic antagonist scopolamine but the underlying molecular mechanism is poorly understood. This study of proteome profiling in the hippocampus could provide conceptual insights into the molecular mechanisms involved in amnesia. To reveal this, mice were administered scopolamine to induce amnesia and memory impairment was validated by novel object recognition test. Using two-dimensional gel electrophoresis coupled with MALDI-MS/MS, we have analyzed the hippocampal proteome and identified 18 proteins which were differentially expressed. Out of these proteins, 11 were downregulated and 7 were upregulated in scopolamine-treated mice as compared to control. In silico analysis showed that the majority of identified proteins are involved in metabolism, catalytic activity, and cytoskeleton architectural functions. STRING interaction network analysis revealed that majority of identified proteins exhibit common association with Actg1 cytoskeleton and Vdac1 energy transporter protein. Furthermore, interaction map analysis showed that Fascin1 and Coronin 1b individually interact with Actg1 and regulate the actin filament dynamics. Vdac1 was significantly downregulated in amnesic mice and showed interaction with other proteins in interaction network. Therefore, we silenced Vdac1 in the hippocampus of normal young mice and found similar impairment in recognition memory of Vdac1 silenced and scopolamine-treated mice. Thus, these findings suggest that Vdac1-mediated disruption of energy metabolism and cytoskeleton architecture might be involved in scopolamine-induced amnesia.
[Mh] Termos MeSH primário: Amnésia/patologia
Regulação da Expressão Gênica/fisiologia
Hipocampo/metabolismo
Proteoma/metabolismo
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Amnésia/induzido quimicamente
Animais
Antagonistas Colinérgicos/toxicidade
Modelos Animais de Doenças
Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Masculino
Camundongos
Proteínas dos Microfilamentos/genética
Proteínas dos Microfilamentos/metabolismo
Mapas de Interação de Proteínas
Proteoma/genética
RNA Interferente Pequeno/farmacologia
Receptores Odorantes/genética
Receptores Odorantes/metabolismo
Recognição (Psicologia)/efeitos dos fármacos
Hidrobrometo de Escopolamina/toxicidade
Fatores de Tempo
Canal de Ânion 1 Dependente de Voltagem/química
Canal de Ânion 1 Dependente de Voltagem/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actins); 0 (Cholinergic Antagonists); 0 (Microfilament Proteins); 0 (Proteome); 0 (RNA, Small Interfering); 0 (Receptors, Odorant); 0 (fascin1 protein, mouse); 145420-64-0 (coronin proteins); 451IFR0GXB (Scopolamine Hydrobromide); EC 1.6.- (Voltage-Dependent Anion Channel 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1002/hipo.22735


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[PMID]:29261656
[Au] Autor:Weed MR; Polino J; Signor L; Bookbinder M; Keavy D; Benitex Y; Morgan DG; King D; Macor JE; Zaczek R; Olson R; Bristow LJ
[Ad] Endereço:Genetically Defined Diseases and Genomics, Bristol-Myers Squibb Company, Wallingford, CT, United States of America.
[Ti] Título:Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
[So] Source:PLoS One;12(12):e0187609, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Agonists at the nicotinic acetylcholine alpha 7 receptor (nAChR α7) subtype have the potential to treat cognitive deficits in patients with Alzheimer's disease (AD) or schizophrenia. Visuo-spatial paired associates learning (vsPAL) is a task that has been shown to reliably predict conversion from mild cognitive impairment to AD in humans and can also be performed by nonhuman primates. Reversal of scopolamine-induced impairment of vsPAL performance may represent a translational approach for the development of nAChR α7 agonists. The present study investigated the effect of treatment with the acetylcholinesterase inhibitor, donepezil, or three nAChR α7 agonists, BMS-933043, EVP-6124 and RG3487, on vsPAL performance in scopolamine-treated cynomolgus monkeys. Scopolamine administration impaired vsPAL performance accuracy in a dose- and difficulty- dependent manner. The impairment of eventual accuracy, a measure of visuo-spatial learning during the task, was significantly ameliorated by treatment with donepezil (0.3 mg/kg, i.m.), EVP-6124 (0.01 mg/kg, i.m.) or BMS-933043 (0.03, 0.1 and 0.3 mg/kg, i.m.). Both nAChR α7 agonists showed inverted-U shaped dose-effect relationships with EVP-6124 effective at a single dose only whereas BMS-933043 was effective across at least a 10 fold dose/exposure range. RG3487 was not efficacious in this paradigm at the dose range examined (0.03-1 mg/kg, i.m.). These results are the first demonstration that the nAChR α7 agonists, EVP-6124 and BMS-933043, can ameliorate scopolamine-induced cognitive deficits in nonhuman primates performing the vsPAL task.
[Mh] Termos MeSH primário: Aprendizagem por Associação de Pares/efeitos dos fármacos
Quinuclidinas/farmacologia
Percepção Espacial/classificação
Compostos de Espiro/farmacologia
Tiofenos/farmacologia
Percepção Visual/efeitos dos fármacos
Receptor Nicotínico de Acetilcolina alfa7/agonistas
[Mh] Termos MeSH secundário: Animais
Indanos/farmacologia
Macaca fascicularis
Masculino
Piperidinas/farmacologia
Quinuclidinas/química
Tempo de Reação/efeitos dos fármacos
Hidrobrometo de Escopolamina
Compostos de Espiro/química
Análise e Desempenho de Tarefas
Tiofenos/química
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7-chloro-N-quinuclidin-3-yl-benzo(b)thiophene-2-carboxamide); 0 (BMS-933043); 0 (Indans); 0 (Piperidines); 0 (Quinuclidines); 0 (Spiro Compounds); 0 (Thiophenes); 0 (alpha7 Nicotinic Acetylcholine Receptor); 451IFR0GXB (Scopolamine Hydrobromide); 8SSC91326P (donepezil)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187609


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[PMID]:29195794
[Au] Autor:Piplani P; Jain A; Devi D; Anjali; Sharma A; Silakari P
[Ad] Endereço:University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India. Electronic address: ppvohra28in@pu.ac.in.
[Ti] Título:Design, synthesis and pharmacological evaluation of some novel indanone derivatives as acetylcholinesterase inhibitors for the management of cognitive dysfunction.
[So] Source:Bioorg Med Chem;26(1):215-224, 2018 01 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study reports the effect of indanone derivatives on scopolamine induced deficit cholinergic neurotransmission serving as promising leads for the therapeutics of cognitive dysfunction. Eleven compounds 54-64 have been designed, synthesised and evaluated against behavioural alterations using step down passive avoidance protocol at a dose of 0.5 mg/kg with Donepezil (1) as the reference standard. All the synthesised compounds were evaluated for their in vitro acetylcholinesterase (AChE) inhibition at five different concentrations using mice brain homogenate as the source of the enzyme. Compounds 54, 56, 59 and 64 displayed appreciable activity with an IC value of 14.06 µM, 12.30 µM, 14.06 µM and 12.01 µM, respectively towards acetylcholinesterase inhibition. The molecular docking study performed to predict the binding mode of the compounds suggested that these compounds could bind appreciably to the amino acids present at the active site of recombinant human acetylcholinesterase (rhAChE). The behavioural, biochemical and in silico pharmacokinetic studies were in concordance with each other.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Aprendizagem da Esquiva/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Disfunção Cognitiva/tratamento farmacológico
Desenho de Drogas
Indanos/farmacologia
[Mh] Termos MeSH secundário: Animais
Inibidores da Colinesterase/administração & dosagem
Inibidores da Colinesterase/química
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/metabolismo
Relação Dose-Resposta a Droga
Feminino
Indanos/administração & dosagem
Indanos/química
Camundongos
Simulação de Acoplamento Molecular
Estrutura Molecular
Hidrobrometo de Escopolamina
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Indans); 451IFR0GXB (Scopolamine Hydrobromide); B926Y9U4QN (indacrinone); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


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[PMID]:28458424
[Au] Autor:Pattanashetti LA; Taranalli AD; Parvatrao V; Malabade RH; Kumar D
[Ad] Endereço:Department of Pharmacology, K.L.E. University's, College of Pharmacy, Belgaum, Karnataka, India.
[Ti] Título:Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats.
[So] Source:Indian J Pharmacol;49(1):60-64, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this study was to evaluate the neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. MATERIALS AND METHODS: Five groups of adult male Wistar rats (12 months old) weighing 180-200 g ( = 6) were used. The normal control group received normal saline and test group animals were pretreated orally with quercetin (25 mg/kg), donepezil (3 mg/kg), and a combination of quercetin (25 mg/kg) with donepezil (3 mg/kg), respectively, dosed at every 24 h interval for 14 consecutive days, afterward amnesia was induced by scopolamine (3 mg/kg) on the 14 day through intraperitoneal route. Cognitive performance was assessed by the Morris water maze, elevated plus maze, and passive avoidance paradigm. Acetylcholinesterase enzyme (AchE) level, biochemical markers such as lipid peroxidase (LPO), glutathione (GSH), ß amyloid level, and histopathological study of rat brain were estimated. Statistical analysis was done by one-way analysis of variance, followed by Dunnett's test. ≥ 0.05 was considered statistically significant. RESULTS: Pretreatment with quercetin, donepezil, and their combination showed a significant increase in escape latency, step-through latency, and decreased transfer latency in respective cognitive models of the Morris water maze, passive avoidance test, and elevated plus maze. Further coadministration significantly decreased AchE level, ß amyloid level as compared to individual therapy. Biochemical markers such as elevated GSH, decreased LPO were observed, and histopathological studies revealed the reversal of neuronal damage in the treatment group ( < 0.05) as compared to scopolamine-treated control group. CONCLUSION: Pretreatment with quercetin potentiates the action of donepezil in scopolamine-induced amnesia in rats. The improved cognitive memory could be due to the synergistic effect of the drugs by decreasing AchE level, ß amyloid level, and antioxidant action in rat brain.
[Mh] Termos MeSH primário: Amnésia/prevenção & controle
Indanos/farmacologia
Fármacos Neuroprotetores/farmacologia
Piperidinas/farmacologia
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Antioxidantes/farmacologia
Aprendizagem da Esquiva/efeitos dos fármacos
Cognição/efeitos dos fármacos
Modelos Animais de Doenças
Sinergismo Farmacológico
Indanos/administração & dosagem
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Fármacos Neuroprotetores/administração & dosagem
Nootrópicos/administração & dosagem
Nootrópicos/farmacologia
Piperidinas/administração & dosagem
Quercetina/administração & dosagem
Ratos
Ratos Wistar
Hidrobrometo de Escopolamina/toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Indans); 0 (Neuroprotective Agents); 0 (Nootropic Agents); 0 (Piperidines); 451IFR0GXB (Scopolamine Hydrobromide); 8SSC91326P (donepezil); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201016


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[PMID]:28873551
[Au] Autor:Cirlini M; Demuth TM; Biancardi A; Rychlik M; Dall'Asta C; Bruni R
[Ad] Endereço:Department of Food and Drug - LS9 Interlab Group, University of Parma, Via G.P. Usberti 95/a, 43134 Parma, Italy.
[Ti] Título:Are tropane alkaloids present in organic foods? Detection of scopolamine and atropine in organic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
[So] Source:Food Chem;239:141-147, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A closer monitoring of tropane alkaloids (TA) in foods is now recommended by the European Commission, following a series of alerts related to the contamination of buckwheat with weeds of the genus Datura. A novel, accurate UHPLC-MS/MS method was developed and validated for the rapid detection of scopolamine and atropine in buckwheat foods. A suitable extraction protocol was set up to maximize recoveries and detection limits in different raw, processed and baked foods. The method offers good performances in terms of sensitivity, accuracy and precision, with LOQs at 0.04 and 0.10µg/kg. The established method is suitable for routine determination of trace levels of TA and was applied to 26 different buckwheat-derived organic foods, detecting TA in 3 samples (13.9-83.9µg/kg for atropine and 5.7-10.4µg/kg for scopolamine). Only in one case the level of contamination was relevant in terms of food safety.
[Mh] Termos MeSH primário: Alimentos Orgânicos
[Mh] Termos MeSH secundário: Alcaloides
Atropina
Cromatografia Líquida de Alta Pressão
Fagopyrum
Seres Humanos
Hidrobrometo de Escopolamina
Espectrometria de Massas em Tandem
Tropanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Tropanes); 451IFR0GXB (Scopolamine Hydrobromide); 7C0697DR9I (Atropine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  8 / 6176 MEDLINE  
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[PMID]:28837785
[Au] Autor:Arafa NMS; Ali EHA; Hassan MK
[Ad] Endereço:Faculty of Science, Biology Department, Jazan University, KSA & National Organization for Drug Control and Research, Department of Physiology, Egypt. Electronic address: nadianeuro@yahoo.com.
[Ti] Título:Canagliflozin prevents scopolamine-induced memory impairment in rats: Comparison with galantamine hydrobromide action.
[So] Source:Chem Biol Interact;277:195-203, 2017 Nov 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Canagliflozin (CAN) is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated to improve glycemic control in adults with type 2 diabetes mellitus. There is a little information about its effect on the cholinergic system that proposed mechanism for memory improvement occurring by SGLT2 drugs. This study aimed to estimate the effect of CAN as compared to galantamine (GAL) treatments for two weeks on scopolamine hydrobromide (SCO)-induced memory dysfunction in experimental rats. Animals divided into six groups; control (CON), CAN, GAL, SCO, SCO + CAN and SCO + GAL. Results indicated significant decrease in body weights of the CAN groups as compared to control values. Moreover, in the SCO + CAN and SCO + GAL the number of arm entry and number of correct alternation in Y maze task increased and showed improvement in the water maze task, acetylcholinesterase (AChE) activities decreased significantly, while monoamines levels significantly increased compared with the SCO group values. Results also recorded acetylcholine M1 receptor (M1 mAChR) in SCO + CAN or SCO + GAL groups in comparison with the SCO group. The study suggested that canagliflozin might improve memory dysfunction induced by scopolamine hydrobromide via cholinergic and monoamines system.
[Mh] Termos MeSH primário: Canagliflozina/uso terapêutico
Hipoglicemiantes/uso terapêutico
Transtornos da Memória/induzido quimicamente
Transtornos da Memória/prevenção & controle
Memória/efeitos dos fármacos
Hidrobrometo de Escopolamina
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Galantamina
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Transtornos da Memória/metabolismo
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0D3Q044KCA (Galantamine); 0SAC974Z85 (Canagliflozin); 451IFR0GXB (Scopolamine Hydrobromide); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


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[PMID]:28833459
[Au] Autor:Casalia ML; Howard MA; Baraban SC
[Ad] Endereço:Epilepsy Research Laboratory, Department of Neurological Surgery and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
[Ti] Título:Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.
[So] Source:Ann Neurol;82(4):530-542, 2017 Oct.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: A significant proportion of the more than 50 million people worldwide currently suffering with epilepsy are resistant to antiepileptic drugs (AEDs). As an alternative to AEDs, novel therapies based on cell transplantation offer an opportunity for long-lasting modification of epileptic circuits. To develop such a treatment requires careful preclinical studies in a chronic epilepsy model featuring unprovoked seizures, hippocampal histopathology, and behavioral comorbidities. METHODS: Transplantation of progenitor cells from embryonic medial or caudal ganglionic eminence (MGE, CGE) were made in a well-characterized mouse model of status epilepticus-induced epilepsy (systemic pilocarpine). Behavioral testing (handling and open field), continuous video-electroencephalographic (vEEG) monitoring, and slice electrophysiology outcomes were obtained up to 270 days after transplantation (DAT). Post-hoc immunohistochemistry was used to confirm cell identity. RESULTS: MGE progenitors transplanted into the hippocampus of epileptic mice rescued handling and open field deficits starting at 60 DAT. In these same mice, an 84% to 88% reduction in seizure activity was observed between 180 and 210 DAT. Inhibitory postsynaptic current frequency, measured on pyramidal neurons in acute hippocampal slices at 270 DAT, was reduced in epileptic mice but restored to naïve levels in epileptic mice receiving MGE transplants. No reduction in seizure activity was observed in epileptic mice receiving intrahippocampal CGE progenitors. INTERPRETATION: Our findings demonstrate that transplanted MGE progenitors enhance functional GABA-mediated inhibition, reduce spontaneous seizure frequency, and rescue behavioral deficits in a chronic epileptic animal model more than 6 months after treatment. Ann Neurol 2017;82:530-542.
[Mh] Termos MeSH primário: Epilepsia/cirurgia
Transplante de Células-Tronco/métodos
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Convulsivantes/toxicidade
Modelos Animais de Doenças
Embrião de Mamíferos
Epilepsia/induzido quimicamente
Comportamento Exploratório/fisiologia
Potenciais Pós-Sinápticos Inibidores/efeitos dos fármacos
Potenciais Pós-Sinápticos Inibidores/fisiologia
Interneurônios/efeitos dos fármacos
Interneurônios/fisiologia
Masculino
Eminência Mediana/citologia
Camundongos
Camundongos Transgênicos
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
Pilocarpina/toxicidade
Hidrobrometo de Escopolamina/toxicidade
Células-Tronco/metabolismo
Fator Nuclear 1 de Tireoide
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Convulsants); 0 (Nuclear Proteins); 0 (Thyroid Nuclear Factor 1); 0 (Transcription Factors); 01MI4Q9DI3 (Pilocarpine); 451IFR0GXB (Scopolamine Hydrobromide); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/ana.25021


  10 / 6176 MEDLINE  
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[PMID]:28830814
[Au] Autor:Kim HB; Lee S; Hwang ES; Maeng S; Park JH
[Ad] Endereço:Graduate School of East-West Medical Science, Kyung Hee University, Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do, 446-701, Republic of Korea.
[Ti] Título:p-Coumaric acid enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments.
[So] Source:Biochem Biophys Res Commun;492(3):493-499, 2017 Oct 21.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to the improvement of medical level, life expectancy increased. But the increased incidence of cognitive disorders is an emerging social problem. Current drugs for dementia treatment can only delay the progress rather than cure. p-Coumaric acid is a phenylpropanoic acid derived from aromatic amino acids and known as a precursor for flavonoids such as resveratrol and naringenin. It was shown to reduce oxidative stress, inhibit genotoxicity and exert neuroprotection. Based on these findings, we evaluated whether p-coumaric acid can protect scopolamine induced learning and memory impairment by measuring LTP in organotypic hippocampal slice and cognitive behaviors in rats. p-Coumaric acid dose-dependently increased the total activity of fEPSP after high frequency stimulation and attenuated scopolamine-induced blockade of fEPSP in the hippocampal CA1 area. In addition, while scopolamine shortened the step-through latency in the passive avoidance test and prolonged the latency as well as reduced the latency in the target quadrant in the Morris water maze test, co-treatment of p-coumaric acid improved avoidance memory and long-term retention of spatial memory in behavioral tests. Since p-coumaric acid improved electrophysiological and cognitive functional deterioration by scopolamine, it may have regulatory effects on central cholinergic synapses and is expected to improve cognitive problems caused by abnormality of the cholinergic nervous system.
[Mh] Termos MeSH primário: Ácidos Cumáricos/farmacologia
Potenciação de Longa Duração/efeitos dos fármacos
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Hidrobrometo de Escopolamina/farmacologia
[Mh] Termos MeSH secundário: Animais
Masculino
Propionatos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Propionates); 451IFR0GXB (Scopolamine Hydrobromide); IBS9D1EU3J (trans-3-(4'-hydroxyphenyl)-2-propenoic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE



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