Base de dados : MEDLINE
Pesquisa : D02.172 [Categoria DeCS]
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[PMID]:29335213
[Au] Autor:Sugawara A; Kubo M; Hirose T; Yahagi K; Tsunoda N; Noguchi Y; Nakashima T; Takahashi Y; Welz C; Mueller D; Mertens C; Koebberling J; Omura S; Sunazuka T
[Ad] Endereço:Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan. Electronic address
[Ti] Título:Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes.
[So] Source:Eur J Med Chem;145:524-538, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Jietacins, an azoxy antibiotic class of chemicals, were isolated from the culture broth of Streptomyces sp. KP-197. They have a unique structural motif, including a vinyl azoxy group and a long acyclic aliphatic chain, which is usually branched but non-branched in the case of jietacin C. During a drug discovery program, we found that jietacins display potent anthelmintic activity against parasitic nematodes and that jietacin A has a moderate or low acute toxicity (LD > 300 mg/kg) and no mutagenic potential in a mini Ames screen. This suggests that jietacins have potential for drug discovery research. In order to create a novel anthelmintic agent, we performed design, synthesis, and biological evaluation of jietacin derivatives against parasitic nematodes. Of these derivatives, we found that a fully synthesized simplified derivative exhibited better anthelmintic activity against three parasitic nematodes than natural jietacins. In addition, it had a better efficacy in vivo through oral administration against a mouse nematode. This indicated that the azoxy motif could prove useful as a template for anthelmintic discovery, possibly creating a class of anthelmintic with novel skeletons, a potential new mode of action, and providing further insight for rational drug design.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Antibacterianos/farmacologia
Compostos Azo/farmacologia
Desenho de Drogas
Nematoides/efeitos dos fármacos
Nippostrongylus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/administração & dosagem
Anti-Helmínticos/química
Antibacterianos/administração & dosagem
Antibacterianos/química
Compostos Azo/administração & dosagem
Compostos Azo/química
Relação Dose-Resposta a Droga
Camundongos
Estrutura Molecular
Testes de Sensibilidade Parasitária
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Anti-Bacterial Agents); 0 (Azo Compounds); 109766-61-2 (jietacin A)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


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[PMID]:29247929
[Au] Autor:Lee SL; Ho LN; Ong SA; Wong YS; Voon CH; Khalik WF; Yusoff NA; Nordin N
[Ad] Endereço:School of Materials Engineering, Universiti Malaysia Perlis, 02600 Arau, Perlis, Malaysia.
[Ti] Título:Role of dissolved oxygen on the degradation mechanism of Reactive Green 19 and electricity generation in photocatalytic fuel cell.
[So] Source:Chemosphere;194:675-681, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, a membraneless photocatalytic fuel cell with zinc oxide loaded carbon photoanode and platinum loaded carbon cathode was constructed to investigate the impact of dissolved oxygen on the mechanism of dye degradation and electricity generation of photocatalytic fuel cell. The photocatalytic fuel cell with high and low aeration rate, no aeration and nitrogen purged were investigated, respectively. The degradation rate of diazo dye Reactive Green 19 and the electricity generation was enhanced in photocatalytic fuel cell with higher dissolved oxygen concentration. However, the photocatalytic fuel cell was still able to perform 37% of decolorization in a slow rate (k = 0.033 h ) under extremely low dissolved oxygen concentration (approximately 0.2 mg L ) when nitrogen gas was introduced into the fuel cell throughout the 8 h. However, the change of the UV-Vis spectrum indicates that the intermediates of the dye could not be mineralized under insufficient dissolved oxygen level. In the aspect of electricity generation, the maximum short circuit current (0.0041 mA cm ) and power density (0.00028 mW cm ) of the air purged photocatalytic fuel cell was obviously higher than that with nitrogen purging (0.0015 mA cm and 0.00008 mW cm ).
[Mh] Termos MeSH primário: Compostos Azo/química
Eletricidade
Eletrólise/métodos
Oxigênio/química
[Mh] Termos MeSH secundário: Carbono
Catálise
Eletrodos
Processos Fotoquímicos
Platina
Óxido de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (reactive green 19); 49DFR088MY (Platinum); 7440-44-0 (Carbon); S88TT14065 (Oxygen); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29024885
[Au] Autor:Jager D; Kupka D; Vaclavikova M; Ivanicova L; Gallios G
[Ad] Endereço:Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 040 01, Kosice, Slovakia.
[Ti] Título:Degradation of Reactive Black 5 by electrochemical oxidation.
[So] Source:Chemosphere;190:405-416, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Degradation of commercial grade Reactive Black 5 (RB5) azo dye by chemical and electrochemical treatment was examined using a dimensionally stable anode and stainless steel cathodes as electrode materials, with NaCl as supporting electrolyte. The electrochemical treatment was compared to the chemical treatment with hypochlorite generated by electrolysis. The compounds present in the commercial grade RB5 azo dye and the products of its electrochemical degradation were separated using ion-pairing high performance liquid chromatography on reversed phase. The separated species were detected by diode array detector and electrospray ionization mass spectrometry. A suitable ion-pairing reversed phase HPLC-MS method with electrospray ionization for the separation and identification of the components was developed. The accurate mass of the parent and fragment ions were used in the determination of the empirical formulas of the components using the first-order mass spectra. Structural formulas of degradation products were proposed using these information and principles of organic chemistry and electrochemistry.
[Mh] Termos MeSH primário: Eletrólise/métodos
Naftalenossulfonatos/química
[Mh] Termos MeSH secundário: Compostos Azo/química
Cromatografia Líquida de Alta Pressão/métodos
Corantes/química
Estrutura Molecular
Peso Molecular
Oxirredução
Espectrometria de Massas por Ionização por Electrospray/métodos
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Coloring Agents); 0 (Naphthalenesulfonates); O0HDY58362 (Remazol black B)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


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[PMID]:29231935
[Au] Autor:Roy S; Samanta D; Kumar P; Maji TK
[Ad] Endereço:Molecular Materials Laboratory, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore-560064, India. tmaji@jncasr.ac.in.
[Ti] Título:Pure white light emission and charge transfer in organogels of symmetrical and unsymmetrical π-chromophoric oligo-p-(phenyleneethynylene) bola-amphiphiles.
[So] Source:Chem Commun (Camb);54(3):275-278, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two novel bola-amphiphilic oligo-p-(phenyleneethynylene) (OPE) dicarboxylates have been synthesized having non-polar and mixed-polar side chains. This led to gelation in both with vesicular morphology. Upon in situ loading of a suitable dye and redox-active molecule, pure white light emitting and charge transfer (CT)-gels, respectively, were realized.
[Mh] Termos MeSH primário: Alquinos/química
Derivados de Benzeno/química
Substâncias Luminescentes/química
Tensoativos/química
[Mh] Termos MeSH secundário: Alquinos/síntese química
Alquinos/efeitos da radiação
Compostos Azo/química
Derivados de Benzeno/síntese química
Derivados de Benzeno/efeitos da radiação
Géis
Luz
Substâncias Luminescentes/síntese química
Substâncias Luminescentes/efeitos da radiação
Nitrilos/química
Tensoativos/síntese química
Tensoativos/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkynes); 0 (Azo Compounds); 0 (Benzene Derivatives); 0 (Gels); 0 (Luminescent Agents); 0 (Nitriles); 0 (Surface-Active Agents); 1518-16-7 (tetracyanoquinodimethane); 69083AX1ZX (methyl red)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc08046h


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[PMID]:29406107
[Au] Autor:Li X; Yuan H; Quan X; Chen S; You S
[Ad] Endereço:Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Ling gong Road 2, Dalian 116024, China.
[Ti] Título:Effective adsorption of sulfamethoxazole, bisphenol A and methyl orange on nanoporous carbon derived from metal-organic frameworks.
[So] Source:J Environ Sci (China);63:250-259, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nanoporous carbons (NPCs) derived from metal-organic frameworks (MOFs) are attracting increasing attention in many areas by virtue of their high specific surface area, large pore volume and unique porosity. The present work reports the preparation of an NPC with high surface area (1731m /g) and pore volume (1.68cm /g) by direct carbonization of MOF-5. We examined the adsorption of three typical contaminants from aqueous solutions, i.e., sulfamethoxazole (SMX), bisphenol A (BPA) and methyl orange (MO), by using the as-prepared NPC. The results demonstrated that NPC could adsorb the contaminants effectively, with adsorption capacity (q ) of 625mg/g (SMX), 757mg/g (BPA) and 872mg/g (MO), respectively. These values were approximately 1.0-3.2 times higher than those obtained for single-walled carbon nanotubes (SWCNTs) and commercial powder active carbon (PAC) under the same conditions. With its high surface area and unique meso/macropore structure, the enhanced adsorption of NPC most likely originates from the cooperative interaction of a pore-filling mechanism, electrostatic interaction, and hydrogen bonding. In particular, the pH value has a crucial impact on adsorption, suggesting the significant contribution of electrostatic interaction between NPC and the contaminants. This study provides a proof-of-concept demonstration of MOF-derived nanoporous carbons as effective adsorbents of contaminants for water treatment.
[Mh] Termos MeSH primário: Compostos Azo/química
Estruturas Metalorgânicas/química
Sulfametoxazol/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Compostos Azo/análise
Compostos Benzidrílicos
Carvão Vegetal
Concentração de Íons de Hidrogênio
Cinética
Nanoporos
Nanotubos de Carbono/química
Fenóis
Porosidade
Sulfametoxazol/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Benzhydryl Compounds); 0 (Metal-Organic Frameworks); 0 (Nanotubes, Carbon); 0 (Phenols); 0 (Water Pollutants, Chemical); 16291-96-6 (Charcoal); 6B4TC34456 (methyl orange); JE42381TNV (Sulfamethoxazole); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29191555
[Au] Autor:Lv M; Ma J; Li Q; Xu H
[Ad] Endereço:Research Institute of Pesticidal Design & Synthesis, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.
[Ti] Título:Discovery of benzotriazole-azo-phenol/aniline derivatives as antifungal agents.
[So] Source:Bioorg Med Chem Lett;28(2):181-187, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of benzotriazole-azo-phenol/aniline derivatives were prepared and evaluated for their antifungal activities against six phytopathogenic fungi such as Fusarium graminearum, Fusarium solani, Alternaria alternate, Valsa mali, Botrytis cinerea, and Curvularia lunata. Among them, compounds IIf, IIn, and IIr showed a broad-spectrum of potent antifungal activities. Especially some compounds displayed 3.5-10.8 folds more potent activities than carbendazim against A. alternata and C. lunata. Notably, compounds IIc, IIm, and IIr exhibited good protective and therapeutic effects against B. cinerea at 200 µg/mL. Their structure-activity relationships were also discussed.
[Mh] Termos MeSH primário: Compostos de Anilina/farmacologia
Antifúngicos/farmacologia
Compostos Azo/farmacologia
Fungos/efeitos dos fármacos
Fenóis/farmacologia
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Compostos de Anilina/química
Antifúngicos/síntese química
Antifúngicos/química
Compostos Azo/química
Relação Dose-Resposta a Droga
Descoberta de Drogas
Testes de Sensibilidade Microbiana
Estrutura Molecular
Fenóis/química
Relação Estrutura-Atividade
Triazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Antifungal Agents); 0 (Azo Compounds); 0 (Phenols); 0 (Triazoles); 86110UXM5Y (benzotriazole); SIR7XX2F1K (aniline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:29371602
[Au] Autor:Gélinas R; Mailleux F; Dontaine J; Bultot L; Demeulder B; Ginion A; Daskalopoulos EP; Esfahani H; Dubois-Deruy E; Lauzier B; Gauthier C; Olson AK; Bouchard B; Des Rosiers C; Viollet B; Sakamoto K; Balligand JL; Vanoverschelde JL; Beauloye C; Horman S; Bertrand L
[Ad] Endereço:Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, 1200, Belgium.
[Ti] Título:AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation.
[So] Source:Nat Commun;9(1):374, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without affecting downstream targets previously suggested to be involved, such as p70 ribosomal S6 protein kinase, calcineurin/nuclear factor of activated T cells (NFAT) and extracellular signal-regulated kinases. Instead, cardiomyocyte hypertrophy is accompanied by increased protein O-GlcNAcylation, which is reversed by AMPK activation. Decreasing O-GlcNAcylation by inhibitors of the glutamine:fructose-6-phosphate aminotransferase (GFAT), blocks cardiomyocyte hypertrophy, mimicking AMPK activation. Conversely, O-GlcNAcylation-inducing agents counteract the anti-hypertrophic effect of AMPK. In vivo, AMPK activation prevents myocardial hypertrophy and the concomitant rise of O-GlcNAcylation in wild-type but not in AMPKα2-deficient mice. Treatment of wild-type mice with O-GlcNAcylation-inducing agents reverses AMPK action. Finally, we demonstrate that AMPK inhibits O-GlcNAcylation by mainly controlling GFAT phosphorylation, thereby reducing O-GlcNAcylation of proteins such as troponin T. We conclude that AMPK activation prevents cardiac hypertrophy predominantly by inhibiting O-GlcNAcylation.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/genética
Acetilglucosamina/metabolismo
Cardiomegalia/genética
Miocárdio/metabolismo
Miócitos Cardíacos/metabolismo
Transferases de Grupos Nitrogenados/genética
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/deficiência
Acetilglucosamina/farmacologia
Acilação/efeitos dos fármacos
Animais
Animais Recém-Nascidos
Azasserina/farmacologia
Compostos Azo/farmacologia
Cardiomegalia/metabolismo
Cardiomegalia/patologia
Ativação Enzimática/efeitos dos fármacos
Ativadores de Enzimas/farmacologia
Regulação da Expressão Gênica
Glicosilação/efeitos dos fármacos
Ventrículos do Coração/efeitos dos fármacos
Ventrículos do Coração/metabolismo
Ventrículos do Coração/patologia
Masculino
Camundongos
Camundongos Knockout
Miocárdio/patologia
Miócitos Cardíacos/efeitos dos fármacos
Miócitos Cardíacos/patologia
Transferases de Grupos Nitrogenados/antagonistas & inibidores
Transferases de Grupos Nitrogenados/metabolismo
Norleucina/análogos & derivados
Norleucina/farmacologia
Fosforilação/efeitos dos fármacos
Cultura Primária de Células
Pironas/farmacologia
Ratos
Ratos Wistar
Transdução de Sinais
Tiofenos/farmacologia
Troponina T/genética
Troponina T/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (6-diazo-5-oxonorleucine); 0 (A 769662); 0 (Azo Compounds); 0 (Enzyme Activators); 0 (Pyrones); 0 (Thiophenes); 0 (Troponin T); 832C8OV84S (Norleucine); 87299V3Q9W (Azaserine); EC 2.6.- (Nitrogenous Group Transferases); EC 2.6.1.16 (Gfpt1 protein, mouse); EC 2.7.11.1 (AMPK alpha2 subunit, mouse); EC 2.7.11.31 (AMP-Activated Protein Kinases); V956696549 (Acetylglucosamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02795-4


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[PMID]:29241121
[Au] Autor:Udayabhanu J; Kannan V; Tiwari M; Natesan G; Giovanni B; Perumal V
[Ad] Endereço:Department of Biotechnology, Periyar University, Periyar Palkalai Nagar, Salem 636 011, Tamil Nadu, India.
[Ti] Título:Nanotitania crystals induced efficient photocatalytic color degradation, antimicrobial and larvicidal activity.
[So] Source:J Photochem Photobiol B;178:496-504, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Textile industries release tonnes of harmful toxic dyes into the environment, causing severe effects on living organisms, including humans. Mosquitoes vectors spread important diseases which cause millions of human deaths worldwide. To control mosquitoes a number of synthetic mosquitocidal agents have been employed but all these pesticides pose harmful effects to human health and non-target species and also led to resistance development in treated vectors. Microbial strains are also developing resistance to the available antibiotics, this currently represents a major public health challenge. The current study is focused on the green synthesis of titanium dioxide nanoparticles (TiO NPs) using aqueous leaf extracts of Euphorbia hirta. Results suggested an efficient remedy for the above mentioned problems using TiO NPs against the dye degradation, mosquito larvae and bacterial pathogens. The fabrication of TiO NPs was confirmed by UV-visible spectroscopy, the biomolecules involved in the synthesis process were evidenced by Fourier transform infra-red spectroscopy (FT-IR), the crystalline structure was observed by using X-ray powder diffraction (XRD) analysis. Spherical shaped TiO NPs were recorded using field emission scanning electron microscopy (FESEM). Energy dispersive X-ray spectroscopy (EDX) results showed the elemental composition of TiO NPs. Enhanced rate of photocatalytic dye degradation efficacy was recorded in in methylene blue (95.8%) followed by crystal violet (86.7%). Antibacterial activity assays indicated growth inhibition was highest in Staphylococcus epidermidis and Proteus vulgaris. The LC of TiO NPs and E. hirta extract on Aedes aegypti larvae were 13.2mg/l and 81.2mg/l, while on Culex quinquefasciatus they were 6.89mg/l and 46.1mg/l respectively. Overall, based on the results of the present study, the green engineered nanotitania could be considered as novel and promising photocatalytic, antibacterial, and mosquitocidal agent.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Corantes/química
Nanopartículas Metálicas/química
Titânio/química
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Aedes/crescimento & desenvolvimento
Animais
Anti-Infecciosos/farmacologia
Compostos Azo/química
Catálise
Escherichia coli/efeitos dos fármacos
Euphorbia/química
Euphorbia/metabolismo
Química Verde
Larva/efeitos dos fármacos
Luz
Nanopartículas Metálicas/toxicidade
Azul de Metileno/química
Fotólise/efeitos dos fármacos
Fotólise/efeitos da radiação
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Azo Compounds); 0 (Coloring Agents); 0 (Plant Extracts); 15FIX9V2JP (titanium dioxide); 6B4TC34456 (methyl orange); D1JT611TNE (Titanium); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  9 / 11098 MEDLINE  
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[PMID]:29121567
[Au] Autor:Li Y; Li L; Chen ZX; Zhang J; Gong L; Wang YX; Zhao HQ; Mu Y
[Ad] Endereço:CAS Key Laboratory of Urban Pollutant Conversion, Collaborative Innovation Centre of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei, China.
[Ti] Título:Carbonate-activated hydrogen peroxide oxidation process for azo dye decolorization: Process, kinetics, and mechanisms.
[So] Source:Chemosphere;192:372-378, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Advanced oxidation processes offer effective solutions in treating wastewater from various industries. This study is the first time to investigate the potential of carbonate-activated hydrogen peroxide (CAP) oxidation process for the removal of organic pollutant from highly alkaline wastewaters. Azo dye acid orange 7 (AO7) was selected as a model pollutant. The influences of various parameters on AO7 decolorization by the CAP oxidation were evaluated. Furthermore, the active species involved in AO7 degradation were explored using scavenger experiments and electron spin resonance analysis. Additionally, AO7 degradation products by the CAP oxidation were identified to elucidate possible transformation pathways. Results showed that the CAP oxidation had better AO7 decolorization performance compared to bicarbonate-activated hydrogen peroxide method. The AO7 decolorization efficiency augmented from 3.70 ± 0.76% to 54.27 ± 2.65% when carbonate concentration was increased from 0 to 50 mM at pH 13.0, and then changed slightly with further increasing carbonate concentration to 70 mM. It increased almost linearly from 5.95 ± 0.32% to 94.03 ± 0.39% as H O concentration was increased from 5 to 50 mM. Moreover, trace amount of Co(II) could facilitate AO7 decolorization by the CAP reaction. Superoxide and carbonate radicals might be the main reactive oxygen species involved in the CAP process. Finally, a possible degradation pathway of AO7 by the CAP oxidation was proposed based on the identified products.
[Mh] Termos MeSH primário: Compostos Azo/química
Carbonatos/química
Corantes/química
Recuperação e Remediação Ambiental/métodos
Peróxidos/química
[Mh] Termos MeSH secundário: Benzenossulfonatos
Bicarbonatos
Poluentes Ambientais/química
Peróxido de Hidrogênio
Cinética
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Benzenesulfonates); 0 (Bicarbonates); 0 (Carbonates); 0 (Coloring Agents); 0 (Environmental Pollutants); 0 (Peroxides); BBX060AN9V (Hydrogen Peroxide); Q1LIY3BO0U (2-naphthol orange)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171110
[St] Status:MEDLINE


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[PMID]:29351309
[Au] Autor:Nieto JA; Zhu J; Duan B; Li J; Zhou P; Paka L; Yamin MA; Goldberg ID; Narayan P
[Ad] Endereço:Department of Preclinical Research, Angion Biomedica Corp., Uniondale, New York, United States of America.
[Ti] Título:A modified elliptical formula to estimate kidney collagen content in a model of chronic kidney disease.
[So] Source:PLoS One;13(1):e0190815, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The extent of scarring or renal interstitial collagen deposition in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky, tissue biopsy. Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area. While treating the kidney as an ellipse with the major axis (a) the polar distance, this technique involves extending the minor axis (b) into the renal pelvis to obtain a new minor axis, be. The calculated renal parenchymal area is remarkably similar to the true or measured area. Biochemically determined kidney collagen content revealed a strong and positive correlation with the calculated renal parenchymal area. Picrosirius red staining for tubulointerstitial collagen also correlated with calculated renal parenchymal area. The extent of renal scarring, i.e. kidney interstitial collagen content, can now be computed by making just two axial measurements which can easily be accomplished via noninvasive imaging of this organ.
[Mh] Termos MeSH primário: Colágeno/metabolismo
Rim/metabolismo
Insuficiência Renal Crônica/metabolismo
[Mh] Termos MeSH secundário: Animais
Compostos Azo
Corantes
Modelos Animais de Doenças
Fibrose
Seres Humanos
Rim/diagnóstico por imagem
Rim/patologia
Masculino
Camundongos
Modelos Biológicos
Tamanho do Órgão
Insuficiência Renal Crônica/diagnóstico por imagem
Insuficiência Renal Crônica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Coloring Agents); 1294D5G72N (C.I. direct red 80); 9007-34-5 (Collagen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190815



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