Base de dados : MEDLINE
Pesquisa : D02.172.030 [Categoria DeCS]
Referências encontradas : 95 [refinar]
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[PMID]:25894779
[Au] Autor:Morozkova TS; Bogdanova LA; Semenov DE; Zhukova NA; Popova NA
[Ad] Endereço:Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, pathol@inbox.ru.
[Ti] Título:PT/Y Mice Are Sensitive to the Inhibitory Effect of o-Aminoazotoluene on Glucocorticoid Induction of Tyrosine Aminotransferase and Its Hepatocarcinogenic Effect.
[So] Source:Bull Exp Biol Med;158(6):789-93, 2015 Apr.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PT/Y mice used for studies of the effects of mutagens are characterized by the absence of spontaneous tumors of the liver, but often develop these tumors in response to chronic oaminoazotoluene treatment. The level of glucocorticoid induction of adaptive hepatic enzyme tyrosine aminotransferase decreases by more than 70% 24 h after acute injection of o-aminoazotoluene to these animals. These mice can serve as a model for studies of the relationship between the effect of carcinogens on the regulation of activity of adaptive hepatic enzymes and their capacity to induce the development of liver tumors.
[Mh] Termos MeSH primário: Glucocorticoides/farmacologia
Fígado/metabolismo
Tirosina Transaminase/metabolismo
o-Aminoazotolueno/toxicidade
[Mh] Termos MeSH secundário: Animais
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); EC 2.6.1.5 (Tyrosine Transaminase); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150506
[Lr] Data última revisão:
150506
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150421
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-2863-3


  2 / 95 MEDLINE  
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[PMID]:25715596
[Au] Autor:Kaledin VI; Il'nitskaia SI; Ovchinnikova LP; Popova NA; Bogdanova LA; Morozkova TS
[Ti] Título:[Mutagenic activation and carcinogenicity of aminoazo dyes of ortho-aminoazotoluene and 3'-methyl-4-dimethylaminoazobenzene in experiments on suckling mice].
[So] Source:Biofizika;59(3):527-32, 2014 May-Jun.
[Is] ISSN:0006-3029
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:It is found that after administration of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB,) which was hepatocarcinogenic to rats, in suckling mice, the number of neoplastic lesions in the liver of mice was 3 times higher than after analogous administration of equimolar dose of ortho-aminoazotoluene (OAT)). However, in the Ames test (TA-98 strain of Salmonella typhimurium) with activation by hepatic enzymes (S-9 fraction) of both intact and Aroclor-1254-induced mice and rats OAT contributed by an order of magnitude to revertant colonies compared to 3'-Me-DAB. In vivo inhibition of sulfotransferase activity, the enzyme which catalyzes the final stage of the mutagenic activation of aminoazo dyes, had no effect on carcinogenicity of 3'-Me-DAB but more than 4 times elevated that of OAT. It was concluded that the mechanism of carcinogenic action of aminoazo dyes studied is not genotoxic and that the carcinogenic potential of OAT is lost in the process of mutagenic activation.
[Mh] Termos MeSH primário: Carcinógenos/toxicidade
Corantes/toxicidade
Neoplasias Hepáticas Experimentais
Metildimetilaminoazobenzeno/toxicidade
Mutagênicos/toxicidade
o-Aminoazotolueno/toxicidade
[Mh] Termos MeSH secundário: Animais
Carcinógenos/farmacologia
Corantes/farmacologia
Fígado/enzimologia
Fígado/patologia
Neoplasias Hepáticas Experimentais/induzido quimicamente
Neoplasias Hepáticas Experimentais/enzimologia
Neoplasias Hepáticas Experimentais/genética
Neoplasias Hepáticas Experimentais/patologia
Metildimetilaminoazobenzeno/farmacologia
Camundongos
Camundongos Endogâmicos CBA
Camundongos Endogâmicos ICR
Mutagênicos/farmacologia
Ratos
Salmonella typhimurium/genética
Salmonella typhimurium/metabolismo
o-Aminoazotolueno/farmacologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Coloring Agents); 0 (Mutagens); 55-80-1 (Methyldimethylaminoazobenzene); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150226
[Lr] Data última revisão:
150226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150227
[St] Status:MEDLINE


  3 / 95 MEDLINE  
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[PMID]:25707246
[Au] Autor:Kaledin VI; Il'nitskaia SI; Popova NA; Baginskaia NV; Bagdanova LA; Perepechaeva ML; Grishanova AIu
[Ti] Título:[Inhibitory effect of ortho-aminoazotoluene on diethylnirtosamine hepatocarcinogenesis in suckling mice. Phenomenon and possible mechanism].
[So] Source:Biofizika;59(4):776-84, 2014 Jul-Aug.
[Is] ISSN:0006-3029
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The modifying effect of the one compound on carcinogenicity of the other in the combined application is attributed usually to some changes in the carcinogen metabolism, i.e. its activation or inactivation. In this paper, when used separately, diethylnitrosamine (DENA) induced 4-6 times more neoplastic lesions in the liver of suckling mice than ortho-aminoazotoluene (OAT) did. However, after combined treatment with both carcinogens the total number of hepatic lesions was significantly lower than that in mice treated with DENA only. Similar effect was observed when OAT was administered 3 days before or 3 days after DENA injection. The observed protective effect is not mediated at metabolic level, because OAT has no effect on metabolism of DENA in mouse liver. Our findings can be unequivocally explained by the competition of the carcinogens for target protein molecules, presumably transcription factors, participating in hepatocyte differentiation, which differently interact with and are diversely impaired by different compounds.
[Mh] Termos MeSH primário: Carcinógenos/farmacologia
Dietilnitrosamina/efeitos adversos
Neoplasias Hepáticas Experimentais
Proteínas de Neoplasias/metabolismo
o-Aminoazotolueno/efeitos adversos
[Mh] Termos MeSH secundário: Alquilantes/efeitos adversos
Alquilantes/farmacologia
Animais
Animais Recém-Nascidos
Corantes/efeitos adversos
Corantes/farmacologia
Dietilnitrosamina/farmacologia
Antagonismo de Drogas
Feminino
Neoplasias Hepáticas Experimentais/induzido quimicamente
Neoplasias Hepáticas Experimentais/metabolismo
Neoplasias Hepáticas Experimentais/patologia
Masculino
Camundongos
Camundongos Endogâmicos CBA
Camundongos Endogâmicos ICR
o-Aminoazotolueno/farmacologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkylating Agents); 0 (Carcinogens); 0 (Coloring Agents); 0 (Neoplasm Proteins); 3IQ78TTX1A (Diethylnitrosamine); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150224
[Lr] Data última revisão:
150224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150225
[St] Status:MEDLINE


  4 / 95 MEDLINE  
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[PMID]:25065317
[Au] Autor:Kaledin VI; Il'nitskaya SI; Popova NA; Bogdanova LA
[Ad] Endereço:Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia, pathol@soramn.ru.
[Ti] Título:Suppression of sulfoconjugation reduces the protective effect of ortho-aminoazotoluene on hepatocarcinogenesis induced by diethylnitrosamine in mice.
[So] Source:Bull Exp Biol Med;157(3):368-70, 2014 Jul.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of ortho-aminoazotoluene on carcinogenic activity of diethylnitrosamine were studied in CBA and ICR mice. Injection of ortho-aminoazotoluene before and after diethylnitrosamine led to a significant reduction of its anticarcinogenic effect, judging from significantly lower level of liver tumors. Pentachlorophenol, inhibitor of sulfotransferase (catalyzing the terminal stage of ortho-aminoazotoluene metabolic activity), stimulated its carcinogenic effect on mouse liver. On the other hand, pentachlorophenol reduced the protective effect of ortho-aminoazotoluene on diethylnitrosamine-induced hepatocarcinogenesis in mice. Presumably, the carcinogenic and anticarcinogenic effects of ortho-aminoazotoluene were realized by its initial form or intermediate (non-sulfated) metabolites.
[Mh] Termos MeSH primário: Anticarcinógenos/farmacologia
Carcinogênese/efeitos dos fármacos
Neoplasias Hepáticas Experimentais/metabolismo
o-Aminoazotolueno/farmacologia
[Mh] Termos MeSH secundário: Animais
Dietilnitrosamina
Feminino
Fígado/química
Fígado/enzimologia
Fígado/patologia
Neoplasias Hepáticas Experimentais/induzido quimicamente
Masculino
Camundongos Endogâmicos CBA
Camundongos Endogâmicos ICR
Pentaclorofenol/farmacologia
Sulfotransferases/antagonistas & inibidores
Sulfotransferases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 3IQ78TTX1A (Diethylnitrosamine); D9BSU0SE4T (Pentachlorophenol); EC 2.8.2.- (Sulfotransferases); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140802
[Lr] Data última revisão:
140802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140729
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-014-2568-z


  5 / 95 MEDLINE  
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[PMID]:23658894
[Au] Autor:Ovchinnikova LP; Bogdanova LA; Kaledin VI
[Ad] Endereço:Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
[Ti] Título:Mutagenic activation reduces carcinogenic activity of ortho-aminoazotoluene for mouse liver.
[So] Source:Bull Exp Biol Med;154(5):664-8, 2013 Mar.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that of ortho-aminoazotoluene in suckling mice. Both 4-aminoazobenzene and ortho-aminoazotoluene exhibited mutagenic activity in Ames' test in vitro on S. typhimurium TA 98 strain with activation with liver enzymes; this mutagenic activity was similarly suppressed by adding pentachlorophenol into activation medium. Induction of xenobiotic metabolism enzymes, stimulating the mutagenic activity of ortho-aminoazotoluene, suppressed its carcinogenic effect on mouse liver. Hence, ortho-aminotoluene (the initial compound), but not its mutagenic metabolites, was the direct active hepatocarcinogen for mice.
[Mh] Termos MeSH primário: Carcinogênese
Carcinógenos/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Pentaclorofenol/farmacologia
o-Aminoazotolueno/metabolismo
[Mh] Termos MeSH secundário: Animais
Testes de Carcinogenicidade
Carcinógenos/toxicidade
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos CBA
Camundongos Endogâmicos ICR
Testes de Mutagenicidade
Pentaclorofenol/química
Pentaclorofenol/metabolismo
o-Aminoazotolueno/química
o-Aminoazotolueno/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); D9BSU0SE4T (Pentachlorophenol); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:130509
[Lr] Data última revisão:
130509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130510
[St] Status:MEDLINE


  6 / 95 MEDLINE  
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[PMID]:23287475
[Au] Autor:Marzi I; Cipolleschi MG; D'Amico M; Stivarou T; Rovida E; Vinci MC; Pandolfi S; Dello Sbarba P; Stecca B; Olivotto M
[Ad] Endereço:Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy.
[Ti] Título:The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming.
[So] Source:Cell Cycle;12(2):353-64, 2013 Jan 15.
[Is] ISSN:1551-4005
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One undisputed milestone of traditional oncology is neoplastic progression, which consists of a progressive selection of dedifferentiated cells driven by a chance sequence of genetic mutations. Recently it has been demonstrated that the overexpression of well-defined transcription factors reprograms somatic cells to the pluripotent stem status. The demonstration raises crucial questions as to whether and to what extent this reprogramming contributes to tumorigenesis, and whether the epigenetic changes involved in it are reversible. Here, we show for the first time that a tumor produced in vivo by a chemical carcinogen is the product of the interaction between neoplastic progression and reprogramming. The experimental model employed the prototype of ascites tumors, the Yoshida AH130 hepatoma and other neoplasias, including human melanoma. AH130 hepatoma was started in the liver by the carcinogen o-aminoazotoluene. This compound binds to and abolishes the p53 protein, producing a genomic instability that promotes both the neoplastic progression and the hepatoma reprogramming. Eventually this tumor contained 100% CD133(+) elements and pO(2)-dependent percentages of the three embryonic transcription factors Nanog, Klf4 and c-Myc. Once transferred into aerobic cultures, the minor cellular fraction expressing this triad generates various types of adherent cells, which are progressively substituted by non-tumorigenic elements committed to fibromuscular, neuronal and glial differentiation. This reprogramming appears to be accomplished stepwise, with the assembly of the triad into a sophisticated transcriptional, oxygen-dependent circuitry, in which Nanog and Klf4 antagonistically regulate c-Myc, and hence, cell hypoxia survival and cell cycle activation.
[Mh] Termos MeSH primário: Desdiferenciação Celular/fisiologia
Transformação Celular Neoplásica/metabolismo
Regulação Neoplásica da Expressão Gênica/fisiologia
Fatores de Transcrição Kruppel-Like/metabolismo
Proteínas Proto-Oncogênicas c-myc/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Animais
Desdiferenciação Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Transformação Celular Neoplásica/efeitos dos fármacos
Primers do DNA/genética
Citometria de Fluxo
Instabilidade Genômica/efeitos dos fármacos
Seres Humanos
Neoplasias Hepáticas Experimentais/induzido quimicamente
Masculino
Microscopia Eletrônica
Proteína Homeobox Nanog
Ratos
Ratos Wistar
Reação em Cadeia da Polimerase em Tempo Real
Proteína Supressora de Tumor p53/metabolismo
o-Aminoazotolueno/metabolismo
o-Aminoazotolueno/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Primers); 0 (GKLF protein); 0 (Kruppel-Like Transcription Factors); 0 (Nanog Homeobox Protein); 0 (Nanog protein, rat); 0 (Proto-Oncogene Proteins c-myc); 0 (Transcription Factors); 0 (Tumor Suppressor Protein p53); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130105
[St] Status:MEDLINE
[do] DOI:10.4161/cc.23200


  7 / 95 MEDLINE  
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[PMID]:23183023
[Au] Autor:Takeuchi A; Jukurogi A; Kaifuku Y; Natsumeda S; Ota H; Yamada S; Sumino K; Kanno S
[Ad] Endereço:Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Japan. a-takeuchi@jisha.or.jp
[Ti] Título:Determination method for p-Phenylazoaniline and 2-methyl-4-(2-tolylazo)aniline in workplace air by high-performance liquid chromatography.
[So] Source:J Occup Health;55(1):43-6, 2013.
[Is] ISSN:1348-9585
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this research was to develop a method for the simultaneous determination of p-Phenylazoaniline (also called 4-aminoazobenzene, AAB) and 2-methyl-4-(2-tolylazo)aniline (also called o-aminoazotoluene, AAT) in workplace air for risk assessment. METHODS: The characteristics of the proposed method, such as recovery, limit of quantitation, reproducibility and storage stability of the samples were examined. RESULTS: An air sampling cassette containing two sulfuric acid-treated glass fiber filters was chosen as the sampler. The AAB and AAT were extracted from the sampler filters by methanol and then analyzed by a high-performance liquid chromatograph equipped with a photo-diode array detector. The overall recoveries from spiked samplers were 77-98 and 85-98% for AAB and AAT, respectively. The recovery after 5 days of storage in a refrigerator exceeded 96%. The overall limits of quantitation were 5.00 and 2.50 µg/sample for AAB and AAT, respectively. The relative standard deviations, which represent the overall reproducibility defined as precision, were 0.6-1.8 and 0.5-2.2% for AAB and AAT, respectively. CONCLUSIONS: The proposed method enables 4-h personal exposure monitoring of AAB and AAT at concentrations of 21 to 2,000 µg/m3 for AAB and 10 to 2,000 µg/m3 for AAT, respectively. The proposed method is useful for estimating worker exposure to AAB and AAT.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Monitoramento Ambiental/métodos
Exposição Ocupacional/análise
o-Aminoazotolueno/química
p-Aminoazobenzeno/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Seres Humanos
Saúde do Trabalhador
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 57X2AH42T1 (p-Aminoazobenzene); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121128
[St] Status:MEDLINE


  8 / 95 MEDLINE  
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[PMID]:22803052
[Au] Autor:Pakharukova MY; Smetanina MA; Ilnitskaya SI; Kaledin VI; Merkulova TI
[Ad] Endereço:Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. pmaria@yandex.ru
[Ti] Título:OAT and 3'MeDAB azo compounds similarly cause liver tumors in GR mice, but differently modify activities of FoxA transcription factors.
[So] Source:Bull Exp Biol Med;152(1):101-4, 2011 Nov.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng; rus
[Ab] Resumo:Transcription factors of the FoxA family (forkhead box A) regulate cell metabolism and differentiation and maintain specificity of liver cell proteome and phenotype of mature hepatocytes. The relationship between hepatocarcinogenicity of azo compounds o-aminoazotoluene (OAT) and 3'-methyl-4-dimethylaminobenzene (3'MeDAB) for GR mice and one of the early events, modulation of the DNA-binding activity of FoxA transcription factor, was studied. Single injection of 3'MeDAB to 12-day-old mice caused liver tumors in 100% males and females similarly as OAT, a well-known mouse hepatocarcinogene. The DNA-binding activity of FoxA in the liver decreased 2.5-3 times by OAT, this resulting in a 40% reduction of glucocorticoid induction of tyrosine aminotransferase (liver-specific gene). In contrast to these, 3'MeDAB did not modify FoxA protein activities or the degree of glucocorticoid induction of tyrosine aminotransferase.
[Mh] Termos MeSH primário: Compostos Azo/toxicidade
Derivados de Benzeno/toxicidade
Fatores Nucleares de Hepatócito/metabolismo
Neoplasias Hepáticas/induzido quimicamente
o-Aminoazotolueno/toxicidade
[Mh] Termos MeSH secundário: Animais
Compostos Azo/farmacologia
Derivados de Benzeno/farmacologia
Feminino
Glucocorticoides
Fígado/efeitos dos fármacos
Fígado/metabolismo
Neoplasias Hepáticas/metabolismo
Masculino
Camundongos
Ligação Proteica
Proteínas Proto-Oncogênicas c-ets/metabolismo
Ativação Transcricional/efeitos dos fármacos
o-Aminoazotolueno/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3'-methyl 4-dimethylazobenzene); 0 (Azo Compounds); 0 (Benzene Derivatives); 0 (Glucocorticoids); 0 (Hepatocyte Nuclear Factors); 0 (Proto-Oncogene Proteins c-ets); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120718
[St] Status:MEDLINE


  9 / 95 MEDLINE  
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[PMID]:21829248
[Au] Autor:National Toxicology Program
[Ti] Título:o-Aminoazotoluene.
[So] Source:Rep Carcinog;12:37-8, 2011.
[Is] ISSN:1551-8280
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinógenos/toxicidade
Corantes/efeitos adversos
o-Aminoazotolueno/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Carcinógenos/química
Corantes/química
Seres Humanos
Neoplasias/induzido quimicamente
o-Aminoazotolueno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Coloring Agents); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110811
[St] Status:MEDLINE


  10 / 95 MEDLINE  
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[PMID]:21809668
[Au] Autor:Kaledin VI; Il'nitskaia SI
[Ti] Título:[Metabolism inhibition stimulates, metabolism activation inhibits cancerogenic activity of ortho-aminoazotoluene in mouse liver].
[So] Source:Vopr Onkol;57(2):216-20, 2011.
[Is] ISSN:0507-3758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Pentachlorophenol, an inhibitor of metabolic activation of aminoazo dyes was administered to suckling mice prior to o-aminoazotoluene (OAT). It was followed by formation of numerous preneoplastic nodules and tumors in the lungs and liver. At the same time, 2,3,7,8-tetrachlorodibenzo-p-dioxine treatment decreased their number in the liver while slightly increasing them in the lung. A possible mechanism of aminoazo dye carcinogenicity is suggested.
[Mh] Termos MeSH primário: Carcinógenos/toxicidade
Corantes/toxicidade
Fígado/patologia
Pulmão/patologia
Dibenzodioxinas Policloradas/farmacologia
Lesões Pré-Cancerosas/induzido quimicamente
o-Aminoazotolueno/toxicidade
[Mh] Termos MeSH secundário: Animais
Biotransformação/efeitos dos fármacos
Fígado/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos CBA
Pentaclorofenol/farmacologia
Dibenzodioxinas Policloradas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Coloring Agents); 0 (Polychlorinated Dibenzodioxins); D9BSU0SE4T (Pentachlorophenol); QHZ900P7ZA (o-Aminoazotoluene)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110804
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde