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[PMID]:28866974
[Au] Autor:Hammond NE; Bellomo R; Gallagher M; Gattas D; Glass P; Mackle D; Micallef S; Myburgh J; Saxena M; Taylor C; Young P; Finfer S
[Ad] Endereço:Critical Care and Trauma Division, The George Institute for Global Health, Sydney, NSW, Australia.
[Ti] Título:The Plasma-Lyte 148 v Saline (PLUS) study protocol: a multicentre, randomised controlled trial of the effect of intensive care fluid therapy on mortality.
[So] Source:Crit Care Resusc;19(3):239-246, 2017 Sep.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: 0.9% sodium chloride (saline) is the most commonly administered resuscitation fluid on a global basis but emerging evidence suggests that its high chloride content may have important adverse effects. OBJECTIVE: To describe the study protocol for the Plasma- Lyte 148 v Saline study, which will test the hypothesis that in critically ill adult patients the use of Plasma-Lyte 148 (a buffered crystalloid solution) for fluid therapy results in different 90-day all-cause mortality when compared with saline. DESIGN AND SETTING: We will conduct this multicentre, blinded, randomised controlled trial in approximately 50 intensive care units in Australia and New Zealand. We will randomly assign 8800 patients to either Plasma-Lyte 148 or saline for all resuscitation fluid, maintenance fluid and compatible drug dilution therapy while in the ICU for up to 90 days after randomisation. OUTCOME MEASURES: The primary outcome is 90-day all-cause mortality; secondary outcomes include mean and peak creatinine concentration, incidence of renal replacement therapy, incidence and duration of vasoactive drug treatment, duration of mechanical ventilation, ICU and hospital length of stay, and quality of life and health services use at 6 months. RESULTS AND CONCLUSIONS: The PLUS study will provide high-quality data on the comparative safety and efficacy of Plasma-Lyte 148 compared with saline for resuscitation and compatible crystalloid fluid therapy in critically ill adult patients.
[Mh] Termos MeSH primário: Estado Terminal/terapia
Hidratação/métodos
Cloreto de Sódio/uso terapêutico
[Mh] Termos MeSH secundário: Austrália
Creatinina/metabolismo
Estado Terminal/mortalidade
Gluconatos/uso terapêutico
Serviços de Saúde/utilização
Seres Humanos
Unidades de Terapia Intensiva
Tempo de Internação
Cloreto de Magnésio/uso terapêutico
Mortalidade
Nova Zelândia
Cloreto de Potássio/uso terapêutico
Qualidade de Vida
Terapia de Substituição Renal/utilização
Respiração Artificial
Ressuscitação
Acetato de Sódio/uso terapêutico
Fatores de Tempo
Vasoconstritores/uso terapêutico
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gluconates); 0 (Plasma-lyte 148); 0 (Vasoconstrictor Agents); 0 (Vasodilator Agents); 02F3473H9O (Magnesium Chloride); 451W47IQ8X (Sodium Chloride); 4550K0SC9B (Sodium Acetate); 660YQ98I10 (Potassium Chloride); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28853155
[Au] Autor:Zhao X; Kasbi M; Chen J; Peres S; Jolicoeur M
[Ad] Endereço:Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, Montréal, Québec, Canada.
[Ti] Título:A dynamic metabolic flux analysis of ABE (acetone-butanol-ethanol) fermentation by Clostridium acetobutylicum ATCC 824, with riboflavin as a by-product.
[So] Source:Biotechnol Bioeng;114(12):2907-2919, 2017 Dec.
[Is] ISSN:1097-0290
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study reveals that supplementing sodium acetate (NaAc) strongly stimulates riboflavin production in acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum ATCC 824 with xylose as carbon source. Riboflavin production increased from undetectable concentrations to ∼0.2 g L (0.53 mM) when supplementing 60 mM NaAc. Of interest, solvents production and biomass yield were also promoted with fivefold acetone, 2.6-fold butanol, and 2.4-fold biomass adding NaAc. A kinetic metabolic model, developed to simulate ABE biosystem, with riboflavin production, revealed from a dynamic metabolic flux analysis (dMFA) simultaneous increase of riboflavin (ribA) and GTP (precursor of riboflavin) (PurM) synthesis flux rates under NaAc supplementation. The model includes 23 fluxes, 24 metabolites, and 72 kinetic parameters. It also suggested that NaAc condition has first stimulated the accumulation of intracellular metabolite intermediates during the acidogenic phase, which have then fed the solventogenic phase leading to increased ABE production. In addition, NaAc resulted in higher intracellular levels of NADH during the whole culture. Moreover, lower GTP-to-adenosine phosphates (ATP, ADP, AMP) ratio under NaAc supplemented condition suggests that GTP may have a minor role in the cell energetic metabolism compared to its contribution to riboflavin synthesis.
[Mh] Termos MeSH primário: Acetona/metabolismo
Butanóis/metabolismo
Clostridium acetobutylicum/metabolismo
Etanol/metabolismo
Análise do Fluxo Metabólico/métodos
Riboflavina/biossíntese
Acetato de Sódio/metabolismo
[Mh] Termos MeSH secundário: Acetona/isolamento & purificação
Reatores Biológicos/microbiologia
Butanóis/isolamento & purificação
Clostridium acetobutylicum/crescimento & desenvolvimento
Simulação por Computador
Meios de Cultura/metabolismo
Etanol/isolamento & purificação
Fermentação
Modelos Biológicos
Riboflavina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanols); 0 (Culture Media); 1364PS73AF (Acetone); 3K9958V90M (Ethanol); 4550K0SC9B (Sodium Acetate); TLM2976OFR (Riboflavin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1002/bit.26393


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[PMID]:28651514
[Au] Autor:Zampieri FG; Azevedo LCP; Corrêa TD; Falavigna M; Machado FR; Assunção MSC; Lobo SMA; Dourado LK; Berwanger O; Kellum JA; Brandão N; Cavalcanti AB; BaSICS Investigators and the BRICNet
[Ad] Endereço:Research Institute HCor, Hospital of Coração, São Paulo, Brazil. abiasi@hcor.com.br.
[Ti] Título:Study protocol for the Balanced Solution versus Saline in Intensive Care Study (BaSICS): a factorial randomised trial.
[So] Source:Crit Care Resusc;19(2):175-182, 2017 Jun.
[Is] ISSN:1441-2772
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The effectiveness and safety of balanced crystalloid fluids compared with saline (0.9% sodium chloride) as a fluid of choice in critically ill patients remain unclear. The effects of different fluid infusion rates on outcomes are also unknown. OBJECTIVES: To test the hypothesis that a balanced crystalloid solution, compared with saline, decreases 90-day all-cause mortality among critically ill patients; and to test the hypothesis that slow, compared with rapid, infusion rate decreases 90-day mortality in this population of patients. METHODS: The Balanced Solution versus Saline in Intensive Care Study (BaSICS) is a pragmatic, 2 ??2 factorial, randomised controlled trial. A total of 11 000 patients will be recruited from at least 100 Brazilian intensive care units. Patients will be randomised to receive Plasma-Lyte 148 or saline, and to rapid infusion (999 mL/h) or slow infusion (333 mL/h). Study fluids will be used for resuscitation episodes (at rapid or slow infusion rates), dilution of compatible medications and maintenance solutions. Patients, health care providers and investigators will be blinded to the solutions being tested. The rate of bolus infusion will not be blinded. OUTCOMES: The primary outcome is 90-day all-cause mortality. Secondary outcomes are: incidence of renal failure requiring renal replacement therapy within 90 days, incidence of acute kidney injury (Kidney Disease: Improving Global Outcomes stages 2 and 3), incidence of non-renal organ dysfunction assessed by Sepsis-related Organ Failure Assessment score at Days 3 and 7, and number of mechanical ventilationfree days within the first 28 days after randomisation. RESULTS AND CONCLUSIONS: The BaSICS trial will provide robust evidence on whether a balanced crystalloid, compared with saline, improves important patient outcomes in critically ill patients. BaSICS will also provide relevant information on whether bolus infusion rate affects outcomes in this population. TRIAL REGISTRATION: ClinicalTrials.gov NCT02875873.
[Mh] Termos MeSH primário: Estado Terminal/mortalidade
Estado Terminal/terapia
Hidratação/métodos
Unidades de Terapia Intensiva
Cloreto de Sódio/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Brasil
Causas de Morte
Método Duplo-Cego
Gluconatos/administração & dosagem
Mortalidade Hospitalar
Seres Humanos
Infusões Intravenosas/métodos
Cloreto de Magnésio/administração & dosagem
Seleção de Pacientes
Cloreto de Potássio/administração & dosagem
Projetos de Pesquisa
Acetato de Sódio/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gluconates); 0 (Plasma-lyte 148); 02F3473H9O (Magnesium Chloride); 451W47IQ8X (Sodium Chloride); 4550K0SC9B (Sodium Acetate); 660YQ98I10 (Potassium Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28317723
[Au] Autor:Mohammadzadeh-Aghdash H; Ezzati Nazhad Dolatabadi J; Dehghan P; Panahi-Azar V; Barzegar A
[Ad] Endereço:Department of Food Science and Technology, Faculty of Nutrition and Food Sciences, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
[Ti] Título:Multi-spectroscopic and molecular modeling studies of bovine serum albumin interaction with sodium acetate food additive.
[So] Source:Food Chem;228:265-269, 2017 Aug 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sodium acetate (SA) has been used as a highly effective protectant in food industry and the possible effect of this additive on the binding to albumin should be taken into consideration. Therefore, for the first time, the mechanism of SA interaction with bovine serum albumin (BSA) has been investigated by multi-spectroscopic and molecular modeling methods under physiological conditions. Stern-Volmer fluorescence quenching analysis showed an increase in the fluorescence intensity of BSA upon increasing the amounts of SA. The high affinity of SA to BSA was demonstrated by a binding constant value (1.09×10 at 310°K). The thermodynamic parameters indicated that hydrophobic binding plays a main role in the binding of SA to Albumin. Furthermore, the results of UV-vis spectra confirmed the interaction of this additive to BSA. In addition, molecular modeling study demonstrated that A binding sites of BSA play the main role in the interaction with acetate.
[Mh] Termos MeSH primário: Aditivos Alimentares/química
Soroalbumina Bovina/química
Acetato de Sódio/química
Espectrometria de Fluorescência/métodos
[Mh] Termos MeSH secundário: Animais
Bovinos
Modelos Moleculares
Simulação de Acoplamento Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives); 27432CM55Q (Serum Albumin, Bovine); 4550K0SC9B (Sodium Acetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28271384
[Au] Autor:Hosseini SM; Bahramnejad B; Douleti Baneh H; Emamifar A; Goodwin PH
[Ad] Endereço:Department of Agronomy and Plant Breeding, University of Kurdistan, P.O. Box: 416, Sanandaj, Iran.
[Ti] Título:Hairy root culture optimization and resveratrol production from Vitis vinifera subsp. sylvesteris.
[So] Source:World J Microbiol Biotechnol;33(4):67, 2017 Apr.
[Is] ISSN:1573-0972
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Resveratrol is a polyphenolic compound produced in very low levels in grapes. To achieve high yield of resveratrol in wild grape, three Agrobacterium rhizogenes strains, Ar318, ArA4 and LBA9402, were used to induce hairy roots following infection of internodes, nodes or petioles of in vitro grown Vitis vinifera subsp. sylvesteris accessions W2 and W16, and cultivar Rasha. The effects of inoculation time, age of explants, bacterial concentration and co-cultivation times were examined on the efficiency of the production of hairy roots. Strains Ar318, ArA4 and LBA9402 all induced hairy roots in the tested genotypes, but the efficiency of ArA4 strain was higher than the other strains. The highest hairy root production was with using internodes as explants. The transformation of hairy roots lines was confirmed by PCR detection of rolB gene. Half Murashige and Skoog (MS) medium was better for biomass production compared with MS medium. HPLC analysis of resveratrol production in the hairy root cultures showed that all the genotypes produced higher amounts of resveratrol than control roots. The highest amount of resveratrol was produced from W16 internode cultures, which was 31-fold higher than that of control root. Furthermore, TLC analysis showed that treatments of hairy roots with sodium acetate and jasmonate elevated resveratrol levels both in hairy root tissue and excreted into the half MS medium. These results demonstrate that endogenous and exogenous factors can affect resveratrol production in hairy root culture of grape, and this strategy could be used to increase low resveratrol production in grapes.
[Mh] Termos MeSH primário: Agrobacterium/fisiologia
Estilbenos/metabolismo
Vitis/genética
Vitis/microbiologia
[Mh] Termos MeSH secundário: Biomassa
Técnicas de Cocultura
Meios de Cultura/química
Ciclopentanos/farmacologia
DNA de Plantas/análise
Genótipo
Técnicas In Vitro
Oxilipinas/farmacologia
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/genética
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/microbiologia
Acetato de Sódio/farmacologia
Vitis/efeitos dos fármacos
Vitis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (Cyclopentanes); 0 (DNA, Plant); 0 (Oxylipins); 0 (Stilbenes); 4550K0SC9B (Sodium Acetate); 6RI5N05OWW (jasmonic acid); Q369O8926L (resveratrol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1007/s11274-017-2235-4


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[PMID]:27719911
[Au] Autor:Jin X; Yang R; Guo L; Wang X; Yan X; Gu Z
[Ad] Endereço:College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, People's Republic of China; College of Life Science, Shandong Normal University, Jinan 250000, People's Republic of China. Electronic address: 2013208009@njau.edu.cn.
[Ti] Título:iTRAQ analysis of low-phytate mung bean sprouts treated with sodium citrate, sodium acetate and sodium tartrate.
[So] Source:Food Chem;218:285-293, 2017 Mar 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of sodium citrate (SC), sodium acetate (SA) and sodium tartrate (ST) spraying on mung bean germination were investigated. Exogenous SC, ST and SA treatments significantly reduced the phytic acid content and increased the antioxidant enzyme activities. In this study, an iTRAQ-based proteomic approach was employed to explore the proteomes of mung bean sprouts, and 81, 101 and 90 differentially expressed proteins were identified in 4-day-old SC-, SA- and ST-treated mung bean sprouts, with 38 proteins present in all samples. Functional classification analysis showed that most of the differentially expressed proteins in mung bean sprouts subjected to the three treatments were involved in carbohydrate and energy metabolism. The inhibitory effect of the SA treatment was probably due to impairments in protein biosynthesis, whereas enhanced energy metabolism, accelerated reserve hydrolysis and protein processing were very important strategies for growth stimulation in response to ST and SC treatments.
[Mh] Termos MeSH primário: Citratos/química
Regulação da Expressão Gênica de Plantas
Ácido Fítico/análise
Acetato de Sódio/química
Tartaratos/química
Vigna/metabolismo
[Mh] Termos MeSH secundário: Fosfatase Ácida/genética
Fosfatase Ácida/metabolismo
Aditivos Alimentares/química
Manipulação de Alimentos
Glicoproteínas/genética
Glicoproteínas/metabolismo
Inositol Polifosfato 5-Fosfatases/genética
Inositol Polifosfato 5-Fosfatases/metabolismo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Biossíntese de Proteínas/efeitos dos fármacos
Proteômica
Regulação para Cima
Vigna/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Food Additives); 0 (Glycoproteins); 0 (Plant Proteins); 0 (Tartrates); 1Q73Q2JULR (sodium citrate); 4550K0SC9B (Sodium Acetate); 7IGF0S7R8I (Phytic Acid); EC 3.1.3.- (purple acid phosphatase); EC 3.1.3.2 (Acid Phosphatase); EC 3.1.3.56 (Inositol Polyphosphate 5-Phosphatases); W4888I119H (tartaric acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27336289
[Au] Autor:Li M; Pan Y; Huang L; Zhang Y; Yang J
[Ad] Endereço:a Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education (MOE) , School of Environmental Science and Technology, Dalian University of Technology , Dalian , People's Republic of China.
[Ti] Título:Continuous flow operation with appropriately adjusting composites in influent for recovery of Cr(VI), Cu(II) and Cd(II) in self-driven MFC-MEC system.
[So] Source:Environ Technol;38(5):615-628, 2017 Mar.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A self-driven microbial fuel cell (MFC) - microbial electrolysis cell (MEC) system, where electricity generated from MFCs is in situ utilized for powering MECs, has been previously reported for recovering Cr(VI), Cu(II) and Cd(II) with individual metals fed in different units of the system in batch operation. Here it was advanced with treating synthetic mixed metals' solution at appropriately adjusting composites in fed-batch and continuous flow operations for complete separation of Cr(VI), Cu(II) and Cd(II) from each other. Under an optimal condition of hydraulic residence time of 4 h, matching of two serially connected MFCs with one MEC, and fed with a composite of either 5 mg L Cr(VI), 1 mg L Cu(II) and 5 mg L Cd(II), or 1 mg L Cr(VI), 5 mg L Cu(II) and 5 mg L Cd(II), the self-driven MFC-MEC system can completely and sequentially recover Cu(II), Cr(VI) and Cd(II) from mixed metals. This study provides a true sustainable and zero-energy-consumed approach of using bioelectrochemical systems for completely recovering and separating Cr(VI), Cu(II) and Cd(II) from each other or from wastes or contaminated sites.
[Mh] Termos MeSH primário: Fontes de Energia Bioelétrica
Cádmio/química
Cromo/química
Cobre/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Eletrólise
Acetato de Sódio/química
Acetato de Sódio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 00BH33GNGH (Cadmium); 0R0008Q3JB (Chromium); 18540-29-9 (chromium hexavalent ion); 4550K0SC9B (Sodium Acetate); 789U1901C5 (Copper)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2016.1205149


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[PMID]:26467268
[Au] Autor:Rouch JA; Burton B; Dabb A; Brown V; Seung AH; Kinsman K; Holdhoff M
[Ad] Endereço:1 Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD, USA.
[Ti] Título:Comparison of enteral and parenteral methods of urine alkalinization in patients receiving high-dose methotrexate.
[So] Source:J Oncol Pharm Pract;23(1):3-9, 2017 Jan.
[Is] ISSN:1477-092X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Purpose Hyperhydration and urinary alkalinization is implemented with all high-dose (HD)-methotrexate infusions to promote excretion and prevent precipitation of methotrexate in the renal tubules. Our institution utilized enteral alkalinizing agents (sodium bicarbonate tablets and sodium citrate/citric acid solution) to alkalinize the urine of patients receiving HD-methotrexate during a parenteral sodium bicarbonate and sodium acetate shortage. The purpose of this study is to establish the safety and efficacy of the enteral route for urine alkalinization. Methods A single-center, retrospective, cohort study was conducted comparing cycles of HD-methotrexate using enteral alkalinizing agents to parenteral sodium bicarbonate. The primary objective was to compare the time, in hours, from administration of first inpatient administered dose of alkalinizing agent to time of achieving goal urine pH. Secondary objectives evaluated total dose of sodium bicarbonate required to achieve goal urine pH, time from start of urine alkalinizing agent until time of achieving methotrexate level safe for discharge, and toxicities associated with methotrexate and the alkalinizing agents. Results A total of 118 patients were included in this study, equally divided into two cohorts based on parenteral versus enteral routes of administration. No statistical difference was determined between the two cohorts regarding time to goal urine pH (6.5 h versus 7.9 h, P = 0.051) or regarding time to methotrexate level deemed safe for discharge (63.5 h versus 62.5 h, p = 0.835). There were no significant differences in methotrexate-induced toxicities. Conclusion Our study found enteral routes of urine alkalinization to be a viable alternative to the traditional parenteral sodium bicarbonate, especially during parenteral sodium bicarbonate and acetate shortages.
[Mh] Termos MeSH primário: Antiácidos/efeitos adversos
Metotrexato/efeitos adversos
Urina/química
[Mh] Termos MeSH secundário: Antiácidos/administração & dosagem
Citratos/efeitos adversos
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Nefropatias/induzido quimicamente
Masculino
Metotrexato/administração & dosagem
Meia-Idade
Estudos Retrospectivos
Acetato de Sódio/efeitos adversos
Bicarbonato de Sódio/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antacids); 0 (Citrates); 1Q73Q2JULR (sodium citrate); 4550K0SC9B (Sodium Acetate); 8MDF5V39QO (Sodium Bicarbonate); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151016
[St] Status:MEDLINE
[do] DOI:10.1177/1078155215610914


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[PMID]:28145854
[Au] Autor:Li D; Fang Z; Long X; Tang R; Di S
[Ad] Endereço:Department of Oil Application & Management Engineering Logistical Engineering University, Chongqing, China.
[Ti] Título:Effects of matrix types on formation and transformation of energy-accumulating substances in enhanced biological phosphorus removal (EBPR).
[So] Source:Cell Mol Biol (Noisy-le-grand);62(14):34-37, 2016 Dec 30.
[Is] ISSN:1165-158X
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Enhanced biological phosphorus removal (EBPR) has been widely used in wastewater treatment. In this study, a laboratory investigation of activated sludge in A/O-SBR reactor was conducted to probe the effects of the matrix types on EBPR polyphosphate, intracellular polysaccharide, polyhydroxyalkanoates (PHA) formation and transformation. There is a decrease in anaerobic condition and an increase in aerobic condition for the intracellular glycogen of sodium propionate matrix and sodium acetate matrix. While the intracellular glycogen of glucose matrix shows a decreasing tendency in both anaerobic and aerobic reaction process. Sodium acetate matrix is beneficial to the formation of polyhydroxybutyrate (PHB), but the content of PHB is relatively small. PHB and poly-3-hydroxyvalerate (PHV) contents in PHA are quite similar in both anaerobic and aerobic reactions with a PHB/PHV ratio of 0.83-1.45. The synthesis of PHV and PHB is mainly in the initial anaerobic stage (0 h - 1 h). Glucose matrix is helpful to the formation of PHV. The content of polymphosphorus shows an increasing tendency in both anaerobic and aerobic stages, suggesting that glucose matrix acclimation of the reactor favors the formation of polymphosphorus.
[Mh] Termos MeSH primário: Fósforo/metabolismo
Esgotos/química
Eliminação de Resíduos Líquidos/métodos
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Aerobiose
Anaerobiose
Bactérias/crescimento & desenvolvimento
Bactérias/metabolismo
Biodegradação Ambiental
Glucose/metabolismo
Glicogênio/metabolismo
Hidroxibutiratos/metabolismo
Fósforo/isolamento & purificação
Poliésteres/metabolismo
Poli-Hidroxialcanoatos/metabolismo
Polissacarídeos/metabolismo
Propionatos/metabolismo
Esgotos/microbiologia
Acetato de Sódio/metabolismo
Valeratos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydroxybutyrates); 0 (Polyesters); 0 (Polyhydroxyalkanoates); 0 (Polysaccharides); 0 (Propionates); 0 (Sewage); 0 (Valerates); 26063-00-3 (poly-beta-hydroxybutyrate); 27YLU75U4W (Phosphorus); 4550K0SC9B (Sodium Acetate); 83120-66-5 (poly(3-hydroxyvalerate)); 9005-79-2 (Glycogen); DK6Y9P42IN (sodium propionate); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.14715/cmb/ 2016.62.14.5


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[PMID]:27808354
[Au] Autor:Xia Y; Zhang XL; Jin F; Wang QX; Xiao R; Hao ZH; Gui QD; Sun J
[Ad] Endereço:Inner Mongolia Medical University, Hohhot, China.
[Ti] Título:Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line.
[So] Source:Genet Mol Res;15(4), 2016 Oct 05.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to investigate the effect of sodium acetate on the viability of the human gastric adenocarcinoma (AGS) epithelial cell line. AGS cells were exposed to a range of concentrations of sodium acetate for different periods of time, and the sodium acetate-induced cytotoxic effects, including cell viability, DNA fragmentation, apoptotic gene expression, and caspase activity, were assessed. The changes in these phenotypes were quantified by performing a lactate dehydrogenase cell viability assay, annexin V staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), and several caspase activity assays. In vitro studies demonstrated that the cytotoxicity of sodium acetate on the AGS cell line were dose- and time-dependent manners. No differences were found between the negative control and sodium acetate-treated cells stained with annexin V and subjected to the TUNEL assay. However, caspase-3 activity was increased in AGS cells exposed to sodium acetate. Overall, it was concluded that sodium acetate exerted an apoptotic effect in AGS cells via a caspase-dependent apoptotic pathway.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Apoptose/efeitos dos fármacos
Células Epiteliais/patologia
Acetato de Sódio/farmacologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/enzimologia
Caspases/metabolismo
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Fragmentação do DNA/efeitos dos fármacos
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/enzimologia
Histonas/metabolismo
Seres Humanos
Neoplasias Gástricas/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histones); 4550K0SC9B (Sodium Acetate); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15048375



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