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Pesquisa : D02.241.081.018.214 [Categoria DeCS]
Referências encontradas : 158 [refinar]
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[PMID]:28319739
[Au] Autor:Tang S; Wang XM; Liu ST; Yang HW; Xie YF; Yang XY
[Ad] Endereço:State Key Joint Laboratory of Environmental Simulation and Pollution Control, Beijing Key Laboratory for Emerging Organic Contaminants Control, School of Environment, Tsinghua University, Beijing, 100084, PR China; Energy and Environment International Centre, School of Energy and Power Engineering,
[Ti] Título:Mechanism and kinetics of halogenated compound removal by metallic iron: Transport in solution, diffusion and reduction within corrosion films.
[So] Source:Chemosphere;178:119-128, 2017 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A detailed kinetic model comprised of mass transport (k ), pore diffusion (k ), adsorption and reduction reaction (k ), was developed to quantitatively evaluate the effect of corrosion films on the removal rate (k ) of halogenated compounds by metallic iron. Different corrosion conditions were controlled by adjusting the iron aging time (0 or 1 yr) and dissolved oxygen concentration (0-7.09 mg/L DO). The k values for bromate, mono-, di- and tri-chloroacetic acids (BrO , MCAA, DCAA and TCAA) were 0.41-7.06, 0-0.16, 0.01-0.53, 0.10-0.73 h , with k values at 13.32, 12.12, 11.04 and 10.20 h , k values at 0.42-5.82, 0.36-5.04, 0.30-4.50, 0.30-3.90 h , and k values at 14.94-421.18, 0-0.19, 0.01-1.30, 0.10-3.98 h , respectively. The variation of k value with reaction conditions depended on the reactant species, while those of k , k and k values were irrelevant to the species. The effects of corrosion films on k and k values were responsible for the variation of k value for halogenated compounds. For a mass-transfer-limited halogenated compound such as BrO , an often-neglected k value primarily determined its k value when pore diffusion was the rate-limiting step of its removal. In addition, the value of k might influence product composition during a consecutive dechlorination, such as for TCAA and DCAA. For a reaction-controlled compound such as MCAA, an increased k value was achieved under low oxic conditions, which was favorable to improve its k value. The proposed model has a potential in predicting the removal rate of halogenated compounds by metallic iron under various conditions.
[Mh] Termos MeSH primário: Bromatos/isolamento & purificação
Cloroacetatos/isolamento & purificação
Ferro/química
Poluentes Químicos da Água/isolamento & purificação
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Bromatos/química
Cloroacetatos/química
Corrosão
Difusão
Cinética
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bromates); 0 (Chloroacetates); 0 (Water Pollutants, Chemical); E1UOL152H7 (Iron)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28107657
[Au] Autor:Heuckendorff M; Jensen HH
[Ad] Endereço:Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
[Ti] Título:Removal of some common glycosylation by-products during reaction work-up.
[So] Source:Carbohydr Res;439:50-56, 2017 Feb 01.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:With the aim of improving the general glycosylation protocol to facilitate easy product isolation it was shown that amide by-products from glycosylation with trichloroacetimidate and N-phenyl trifluoroacetimidate donors could be removed during reaction work-up by washing with a basic aqueous solution. Excess glycosyl acceptor or lactol originating from glycosyl donor hydrolysis could equally be removed from the reaction mixture by derivatization with a basic tag and washing with an acidic solution during reaction work-up.
[Mh] Termos MeSH primário: Acetamidas/isolamento & purificação
Cloroacetatos/química
Tioglicosídeos/química
[Mh] Termos MeSH secundário: Técnicas de Química Sintética
Cloroacetatos/isolamento & purificação
Diaminas/química
Glicosilação
Hidrólise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetamides); 0 (Chloroacetates); 0 (Diamines); 0 (Thioglycosides); I8BL3305RO (trichloroacetamide); I98I2UEC03 (3-dimethylaminopropylamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


  3 / 158 MEDLINE  
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[PMID]:27576348
[Au] Autor:Su X; Li R; Tsang JS
[Ad] Endereço:Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: xbsu@sjtu.edu.cn.
[Ti] Título:The 228bp upstream non-coding region of haloacids transporter gene dehp2 has regulated promoter activity.
[So] Source:Gene;593(2):322-9, 2016 Nov 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Biodegradation is an effective way to remove environmental pollutants haloacids, and haloacids uptake is an important step besides cytoplasmic dehalogenation. Previous study has identified a robust haloacids transport system in Burkholderia caribensis MBA4 with two homologous genes deh4p and dehp2 as major players. Both genes are inducible by monochloroacetate (MCA), and dehp2 is conserved among the Burkholderia genus with a two component system upstream. Here we show that dehp2 is not in the same operon with the upstream two component system, and fusion with lacZ confirmed the presence of MCA-inducible promoter activity in the 228bp upstream non-coding region of dehp2. Serial deletion confirmed 112bp upstream is enough for basic promoter activity, but sequence further upstream is useful for enhanced promoter activity. Electrophoretic mobility shift assay of the 228bp region showed a retardation complex with stronger hybridization in the induced condition, suggesting a positive regulation pattern. Regulator(s) binding region was found to lie between -228 to -113bp of dehp2. Quantitative real-time PCR showed that the expressions of dehp2 orthologs in three other Burkholderia species were also MCA-inducible, similar as dehp2. The 5' non-coding regions of these dehp2 orthologs have high sequence similarity with dehp2 promoter, and 100bp upstream of dehp2 orthologs is especially conserved. Our study identified a promoter of haloacids transporter gene that is conserved in the Burkholderia genus, which will benefit future exploitation of them for effective biodegradation of haloacids.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Proteínas de Transporte/genética
Regulação Bacteriana da Expressão Gênica
Regiões Promotoras Genéticas
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
Burkholderia/efeitos dos fármacos
Burkholderia/genética
Proteínas de Transporte/metabolismo
Cloroacetatos/farmacologia
Sequência Conservada
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Carrier Proteins); 0 (Chloroacetates)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160901
[St] Status:MEDLINE


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[PMID]:27362425
[Au] Autor:Schlüter T; Ziyaei Halimehjani A; Wachtendorf D; Schmidtmann M; Martens J
[Ad] Endereço:Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
[Ti] Título:Four-Component Reaction for the Synthesis of Dithiocarbamates Starting from Cyclic Imines.
[So] Source:ACS Comb Sci;18(8):456-60, 2016 Aug 08.
[Is] ISSN:2156-8944
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An efficient one-pot, four-component reaction for the synthesis of dithiocarbamates using carbon disulfide, cyclic imines, acid chlorides, and commercially available primary or secondary amines has been developed by performing an acid chloride addition to a heterocyclic imine followed by subsequent nucleophilic substitution of in situ generated dithiocarbamic acid. With the aid of the newly developed and powerful multicomponent reaction, a direct route for the synthesis of 24 unknown dithiocarbamates in moderate to good yield under mild conditions is enabled.
[Mh] Termos MeSH primário: Dissulfeto de Carbono/química
Iminas/química
Bibliotecas de Moléculas Pequenas/química
Tiocarbamatos/síntese química
[Mh] Termos MeSH secundário: Aminas/química
Cloroacetatos/química
Técnicas de Química Combinatória
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Chloroacetates); 0 (Imines); 0 (Small Molecule Libraries); 0 (Thiocarbamates); S54S8B99E8 (Carbon Disulfide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1021/acscombsci.6b00029


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[PMID]:27213572
[Au] Autor:Park KY; Choi SY; Lee SH; Kweon JH; Song JH
[Ad] Endereço:Department of Environmental Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea.
[Ti] Título:Comparison of formation of disinfection by-products by chlorination and ozonation of wastewater effluents and their toxicity to Daphnia magna.
[So] Source:Environ Pollut;215:314-321, 2016 Aug.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study compared the two most frequently used disinfectants (i.e., chlorine and ozone) to understand their efficiency in wastewater effluents and the ecotoxicity of disinfection by-products created during chlorination and ozonation. Four trihalomethanes (THMs) and nine haloacetic acids (HAAs) were measured from a chlorine-disinfected sample and two aldehydes (i.e., formaldehydes and acetaldehydes) were analyzed after ozonation. Chlorination was effective for total coliform removal with Ct value in the range of 30-60 mg-min/L. Over 1.6 mg/L of ozone dose and 0.5 min of the contact time presented sufficient disinfection efficiency. The concentration of THMs increased with longer contact time (24 h), but that of HAAs showed little change with contact time. The measured concentration of formaldehyde at the ozone dose of 1.6 mg/L and the contact time of 9 min showed the greatest value in this study, approximately 330 µg L(-1), from which the corresponding ecotoxicity was determined using an indicator species, Daphnia magna. The ecotoxicity results were consistent with the toxicological features judged by occurrence, genotoxicity, and carcinogenicity. Both the disinfection efficiency as well as the DBP formation potential should therefore be considered to avoid harmful impacts on aquatic environments when a disinfection method is used for wastewater effluents.
[Mh] Termos MeSH primário: Cloro/química
Daphnia/efeitos dos fármacos
Desinfetantes/química
Desinfecção/métodos
Halogenação
Ozônio/química
Águas Residuais/química
[Mh] Termos MeSH secundário: Acetaldeído/análise
Acetaldeído/toxicidade
Animais
Cloro/toxicidade
Cloroacetatos/análise
Cloroacetatos/toxicidade
Desinfetantes/toxicidade
Formaldeído/análise
Formaldeído/toxicidade
Ozônio/toxicidade
Trialometanos/análise
Trialometanos/toxicidade
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/toxicidade
Purificação da Água/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chloroacetates); 0 (Disinfectants); 0 (Trihalomethanes); 0 (Waste Water); 0 (Water Pollutants, Chemical); 1HG84L3525 (Formaldehyde); 4R7X1O2820 (Chlorine); 66H7ZZK23N (Ozone); GO1N1ZPR3B (Acetaldehyde)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170805
[Lr] Data última revisão:
170805
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


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[PMID]:26717545
[Au] Autor:Ali SP; Jalsa NK
[Ad] Endereço:Department of Chemistry, The University of the West Indies, St. Augustine, Trinidad and Tobago.
[Ti] Título:Synthesis of a 2-N,N-dibenzylamino glucopyranosyl trichloroacetimidate glycosyl donor and evaluation of its utility in stereoselective glycosylation.
[So] Source:Carbohydr Res;420:13-22, 2016 Feb.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The 2-N,N-dibenzylamino glucopyranosyl trichloroacetimidate donor was synthesized and an extensive investigation of its glycosyl donor properties was conducted. Coupling studies incorporated a variety of glycosyl promoters and a range of acceptor alcohols representing different reactivities and protecting group patterns. Various reaction temperatures, solvents and glycosylation protocols were also examined. Exclusive ß-stereoselectivity was obtained in moderate to good yields with eight novel glycosides being produced, by probable neighbouring group participation via the formation of an aziridinium ion intermediate. Plausible reaction mechanisms were proposed based on the results obtained.
[Mh] Termos MeSH primário: Acetamidas/química
Cloroacetatos/química
Glicosídeos/síntese química
[Mh] Termos MeSH secundário: Glicosídeos/química
Glicosilação
Estrutura Molecular
Estereoisomerismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetamides); 0 (Chloroacetates); 0 (Glycosides); I8BL3305RO (trichloroacetamide)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151231
[St] Status:MEDLINE


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[PMID]:26398451
[Au] Autor:Tang HL; Xie YF
[Ad] Endereço:Department of Water Engineering and Science, College of Civil Engineering, Hunan University, Changsha, Hunan 410082, China; Minn Water LLC, Minneapolis, MN 55441, USA. Electronic address: tang@minnwater.com.
[Ti] Título:Biologically active carbon filtration for haloacetic acid removal from swimming pool water.
[So] Source:Sci Total Environ;541:58-64, 2016 Jan 15.
[Is] ISSN:1879-1026
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A biologically activate carbon (BAC) filter was continuously operated on site for the treatment of haloacetic acids (HAAs) in an outdoor swimming pool at an average empty bed contact time (EBCT) of 5.8 min. Results showed that BAC filtration was a viable technology for direct removal of HAAs from the pool water with a nominal efficiency of 57.7% by the filter while the chlorine residuals were 1.71 ± 0.90 mg/L during the study. THMs and TOC were not removed and thus were not considered as indicators of the effectiveness of BAC filtration. Increased EBCT in the range of 4.5 and 6.4 min led to improved HAA removal performance, which could be best fit by a logarithmic regression model. BAC filtration also affected the HAA speciation by removing more dichloroacetic acid (DCAA) than trichloroacetic acid (TCAA), resulting in a lower ratio of DCAA/TCAA in the filtered effluent. However, the observation of an overall constant ratio could be attributable to a complex formation and degradation mechanism occurring in swimming pools.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Cloroacetatos/análise
Filtração/métodos
Piscinas
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Cloroacetatos/química
Ácido Dicloroacético/análise
Ácido Dicloroacético/química
Desinfecção
Ácido Tricloroacético
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chloroacetates); 0 (Water Pollutants, Chemical); 16291-96-6 (Charcoal); 5V2JDO056X (Trichloroacetic Acid); 9LSH52S3LQ (Dichloroacetic Acid)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150924
[St] Status:MEDLINE


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[PMID]:26364220
[Au] Autor:Huang H; Wu QY; Tang X; Jiang R; Hu HY
[Ad] Endereço:School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510275, Guangdong, PR China; State Key Joint Laboratory of Environment Simulation and Pollution Control, School of En
[Ti] Título:Formation of haloacetonitriles and haloacetamides and their precursors during chlorination of secondary effluents.
[So] Source:Chemosphere;144:297-303, 2016 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The formation of dichloroacetonitrile (DCAN), dichloroacetamide (DCAcAm) and trichloroacetamide (TCAcAm) during chlorination of secondary effluents was evaluated under different conditions. The formation of DCAN and DCAcAm increased, then decreased with increasing contact time and chlorine dose, while TCAcAm formation increased continually, exceeding DCAcAm formation after a relatively long contact time or in response to a relatively high chlorine dose (20-80 mg L(-1)). Increasing the sample pH from 6 to 9 reduced the formation of DCAN and TCAcAm, while DCAcAm formation was highest at pH 8. Precursors in the secondary effluent were characterized by separating the organic matter into several fractions using membrane filtration and XAD resins and then measuring the formation of DCAN, DCAcAm and TCAcAm from each fraction during chlorination. Dissolved organic matter (DOM) with a molecular weight less than 1 kDa dominated the formation of DCAcAm and TCAcAm. However, particle-associated DCAN precursors were detected in addition to potent DCAN precursors in the DOM fractions. Among the XAD fractions of DOM, the hydrophilic neutral fraction prevailed in the secondary effluent and produced the most DCAN, DCAcAm and TCAcAm per volume, and the hydrophilic basic fraction with a low organic content had the highest yields of DCAN, DCAcAm and TCAcAm on a DOC basis, so their dominant precursors were associated with hydrophilic matter.
[Mh] Termos MeSH primário: Acetamidas/análise
Acetonitrilos/análise
Cloro/química
Cloroacetatos/análise
Águas Residuais/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Desinfecção
Filtração
Halogenação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetamides); 0 (Acetonitriles); 0 (Chloroacetates); 0 (Waste Water); 0 (Water Pollutants, Chemical); 4R7X1O2820 (Chlorine); I202LTA03D (2,2-dichloroacetamide); I8BL3305RO (trichloroacetamide); O0L64V63M9 (dichloroacetonitrile)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150914
[St] Status:MEDLINE


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[PMID]:26394759
[Au] Autor:Chu W; Li X; Gao N; Deng Y; Yin D; Li D; Chu T
[Ad] Endereço:State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China.
[Ti] Título:Peptide bonds affect the formation of haloacetamides, an emerging class of N-DBPs in drinking water: free amino acids versus oligopeptides.
[So] Source:Sci Rep;5:14412, 2015 Sep 23.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Haloacetamides (HAcAms), an emerging class of nitrogenous disinfection by-products (N-DBPs) of health concern, have been frequently identified in drinking waters. It has long been appreciated that free amino acids (AAs), accounting for a small fraction of the dissolved organic nitrogen (DON) pool, can form dichloroacetamide (DCAcAm) during chlorination. However, the information regarding the impacts of combined AAs, which contribute to the greatest identifiable DON portion in natural waters, is limited. In this study, we compared the formation of HAcAms from free AAs (tyrosine [Tyr] and alanine [Ala]) and combined AAs (Tyr-Ala, Ala-Tyr, Tyr-Tyr-Tyr, Ala-Ala-Ala), and found that HAcAm formation from the chlorination of AAs in combined forms (oligopeptides) significantly exhibited a different pattern with HAcAm formation from free AAs. Due to the presence of peptide bonds in tripeptides, Tyr-Tyr-Tyr and Ala-Ala-Ala produced trichloroacetamide (TCAcAm) in which free AAs was unable to form TCAcAm during chlorination. Moreover, peptide bond in tripeptides formed more tri-HAcAms than di-HAcAms in the presence of bromide. Therefore, the peptide bond may be an important indicator to predict the formation of specific N-DBPs in chlorination. The increased use of algal- and wastewater-impacted water as drinking water sources will increase health concerns over exposure to HAcAms in drinking water.
[Mh] Termos MeSH primário: Acetamidas/química
Cloroacetatos/química
Desinfetantes/química
Água Potável/análise
Águas Residuais/análise
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Acetamidas/análise
Aminoácidos/química
Cloroacetatos/análise
Dipeptídeos/química
Desinfetantes/análise
Desinfecção
Água Potável/química
Halogenação/fisiologia
Nitrogênio/química
Oligopeptídeos/química
Águas Residuais/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetamides); 0 (Amino Acids); 0 (Chloroacetates); 0 (Dipeptides); 0 (Disinfectants); 0 (Drinking Water); 0 (Oligopeptides); 0 (Waste Water); 0 (Water Pollutants, Chemical); 1050-28-8 (tyrosyltyrosine); 3061-88-9 (alanyltyrosine); 5874-90-8 (alanyl-alanyl-alanine); I202LTA03D (2,2-dichloroacetamide); I8BL3305RO (trichloroacetamide); N762921K75 (Nitrogen)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150924
[St] Status:MEDLINE
[do] DOI:10.1038/srep14412


  10 / 158 MEDLINE  
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[PMID]:26348569
[Au] Autor:Zhang Q; Stockdale DP; Mixdorf JC; Topczewski JJ; Nguyen HM
[Ad] Endereço:Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
[Ti] Título:Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates.
[So] Source:J Am Chem Soc;137(37):11912-5, 2015 Sep 23.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Ir-catalyzed enantioselective fluorination of racemic, branched allylic trichloroacetimidates with Et3N·3HF is a mild and efficient route for selective incorporation of fluoride ion into allylic systems. We herein describe the asymmetric fluorination of racemic, secondary allylic electrophiles with Et3N·3HF using a chiral-diene-ligated Ir complex. The methodology enables the formation of acyclic fluorine-containing compounds in good yields with excellent levels of asymmetric induction and overcomes the limitations previously associated with the enantioselective construction of secondary allylic fluorides bearing α-linear substituents.
[Mh] Termos MeSH primário: Acetamidas/química
Cloroacetatos/química
Halogenação
Irídio/química
[Mh] Termos MeSH secundário: Catálise
Modelos Moleculares
Conformação Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetamides); 0 (Chloroacetates); 44448S9773 (Iridium); I8BL3305RO (trichloroacetamide)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171115
[Lr] Data última revisão:
171115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150909
[St] Status:MEDLINE
[do] DOI:10.1021/jacs.5b07492



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