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[PMID]:29016608
[Au] Autor:Beard JD; Engel LS; Richardson DB; Gammon MD; Baird C; Umbach DM; Allen KD; Stanwyck CL; Keller J; Sandler DP; Schmidt S; Kamel F
[Ad] Endereço:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
[Ti] Título:Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis survival.
[So] Source:PLoS One;12(10):e0185751, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Military veterans may have higher rates of amyotrophic lateral sclerosis (ALS) mortality than non-veterans. Few studies, with sparse exposure information and mixed results, have studied relationships between military-related factors and ALS survival. We evaluated associations between military-related factors and ALS survival among U.S. military veteran cases. METHODS: We followed 616 medical record-confirmed cases from enrollment (2005-2010) in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study until death or July 25, 2013, whichever came first. We ascertained vital status information from several sources within the Department of Veterans Affairs. We obtained information regarding military service, deployments, and 39 related exposures via standardized telephone interviews. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals. We adjusted for potential confounding and missing covariate data biases via inverse probability weights. We also used inverse probability weights to adjust for potential selection bias among a case group that included a disproportionate number of long-term survivors at enrollment. RESULTS: We observed 446 deaths during 24,267 person-months of follow-up (median follow-up: 28 months). Survival was shorter for cases who served before 1950, were deployed to World War II, or mixed and applied burning agents, with HRs between 1.58 and 2.57. Longer survival was associated with exposure to: paint, solvents, or petrochemical substances; local food not provided by the Armed Forces; or burning agents or Agent Orange in the field with HRs between 0.56 and 0.73. CONCLUSIONS: Although most military-related factors were not associated with survival, associations we observed with shorter survival are potentially important because of the large number of military veterans.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/epidemiologia
Militares
Sobreviventes/estatística & dados numéricos
Veteranos
[Mh] Termos MeSH secundário: Ácido 2,4,5-Triclorofenoxiacético/toxicidade
Ácido 2,4-Diclorofenoxiacético/toxicidade
Adulto
Idoso
Agente Laranja
Esclerose Amiotrófica Lateral/etiologia
Esclerose Amiotrófica Lateral/mortalidade
Conflitos Armados/história
Substâncias para a Guerra Química/toxicidade
Exposição Ambiental/efeitos adversos
Feminino
História do Século XX
História do Século XXI
Seres Humanos
Masculino
Registros Médicos/estatística & dados numéricos
Meia-Idade
Dibenzodioxinas Policloradas/toxicidade
Modelos de Riscos Proporcionais
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185751


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[PMID]:28527418
[Au] Autor:Ngo TH; Hien TT; Thuan NT; Minh NH; Chi KH
[Ad] Endereço:Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei 112, Taiwan; International Health Program, National Yang Ming University, Taipei 112, Taiwan.
[Ti] Título:Atmospheric PCDD/F concentration and source apportionment in typical rural, Agent Orange hotspots, and industrial areas in Vietnam.
[So] Source:Chemosphere;182:647-655, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vietnam has a double burden of dioxin from both industrial sources and historical sources. To evaluate the concentration of PCDD/Fs in ambient air in different areas of Vietnam and their possible sources, atmospheric samples were collected from three areas namely Son La (rural area) and Da Nang (harbor - Agent Orange hotspot area), and Ho Chi Minh City (metropolitan - industrial city). Vapor and solid phases of PCDD/Fs were collected and analyzed following the TO-9A sampling method. Principal Component Analysis and Positive Matrix Factorization model were applied to characterize the possible source. The average concentrations of PCDD/Fs were found to be 21.3 ± 13 fg I-TEQ/m in Son La (n = 32), 65.2 ± 34 fg I-TEQ/m in Da Nang (n = 16) and 139 ± 84 fg I-TEQ/m in Ho Chi Minh City (n = 8). The findings of this study targeted open burning (42%) and biomass burning (51%) as the major emission sources of PCDD/Fs in ambient air of Son La, Vietnam. Major possible sources of PCDD/Fs in Da Nang could be transportation activities (64%), however, the other factor (36%) was suspected to be contaminated with 2,3,7,8-TeCDD from Agent Orange. Most of PCDD/Fs emitted in Ho Chi Minh City related to industrial activities (93%).
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/análise
Ácido 2,4-Diclorofenoxiacético/análise
Poluentes Atmosféricos/análise
Benzofuranos/análise
Dioxinas/análise
Dibenzodioxinas Policloradas/análise
[Mh] Termos MeSH secundário: Agente Laranja
Monitoramento Ambiental/métodos
Indústrias
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Benzofurans); 0 (Dioxins); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE


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[PMID]:27908921
[Au] Autor:Khan K; Wozniak SE; Coleman J; Didolkar MS
[Ad] Endereço:Department of General Surgery, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
[Ti] Título:Wartime toxin exposure: recognising the silent killer.
[So] Source:BMJ Case Rep;2016, 2016 Dec 01.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Wartime toxin exposures have been implicated in the genesis of malignancy in war veterans. Agent Orange, one toxin among many, has been linked to malignancy and the subcomponent phenoxyacetic acid has been associated with soft tissue sarcomas (STSs). This case demonstrates the association between a wartime toxin exposure (Agent Orange) and subsequent cancer development. Ultimately, we aim to highlight the importance of simple, specific questions in the patient history to account for previous wartime toxin exposures.
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/envenenamento
Ácido 2,4-Diclorofenoxiacético/envenenamento
Guerra Química
Desfolhantes Químicos/envenenamento
Exposição Ambiental/efeitos adversos
Anamnese
Dibenzodioxinas Policloradas/envenenamento
Sarcoma/induzido quimicamente
Veteranos
Guerra do Vietnã
[Mh] Termos MeSH secundário: Administração Cutânea
Agente Laranja
Seres Humanos
Masculino
Meia-Idade
Medição de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Defoliants, Chemical); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:27748632
[Au] Autor:Klickermann F
[Ad] Endereço:a School of Law , Trinity College , Dublin , Ireland.
[Ti] Título:Legal liability for Agent Orange-related illnesses: a reassessment of the 2005 VAVA case and prospects for new litigation.
[So] Source:Med Confl Surviv;32(2):138-152, 2016 Apr-Jun.
[Is] ISSN:1362-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Attempts through the US courts to hold the corporations responsible for the production of dioxin-contaminated herbicides used by the US military in the 1960s and early 1970s liable for their ongoing health consequences have failed. This article scrutinizes the most recent judgement - that of the United States District Court for the Eastern District of New York handed down in 2005 following a lawsuit brought by the Vietnam Association of Victims of Agent Orange/dioxin (VAVA). It is argued that despite this judgement there is the potential to bring a further legal case, with some prospect of success, on the basis of: (i) debatable legal judgements in the 2005 decision; (ii) new scientific evidence on the health effects of exposure to Agent Orange; and (iii) cases brought in other jurisdictions. The article concludes by noting the underfunding of ongoing remediation efforts, especially for the provision of assistance to affected individuals, and argues that it is desirable to oblige the producers of the herbicides to contribute financially to these efforts.
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/efeitos adversos
Ácido 2,4-Diclorofenoxiacético/efeitos adversos
Indústria Química/legislação & jurisprudência
Desfolhantes Químicos/efeitos adversos
Responsabilidade Legal
Dibenzodioxinas Policloradas/efeitos adversos
[Mh] Termos MeSH secundário: Agente Laranja
Causalidade
Seres Humanos
Direito Internacional
Estados Unidos
Veteranos/legislação & jurisprudência
Guerra do Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Defoliants, Chemical); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27466931
[Au] Autor:Collins AM
[Ti] Título:Peace and Reconciliation.
[So] Source:Am J Nurs;116(8):55-7, 2016 Aug.
[Is] ISSN:1538-7488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Susan Schnall speaks about the lingering effects of Agent Orange-and what remains to be done about them.
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/toxicidade
Ácido 2,4-Diclorofenoxiacético/toxicidade
Anormalidades Congênitas/etiologia
Substâncias Perigosas/toxicidade
Acesso aos Serviços de Saúde
Dibenzodioxinas Policloradas/toxicidade
Condições Sociais
[Mh] Termos MeSH secundário: Agente Laranja
Atitude do Pessoal de Saúde
Anormalidades Congênitas/terapia
Seres Humanos
Internacionalidade
Papel do Profissional de Enfermagem
Ajuda a Veteranos Incapacitados/legislação & jurisprudência
Vietnã
Guerra do Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1097/01.NAJ.0000490181.44302.09


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[PMID]:27296963
[Au] Autor:Hayashi S; Sano T; Suyama K; Itoh K
[Ad] Endereço:Faculty of Life and Environmental Science, Shimane University 1060 Nishikawatsu, Matsue, Shimane 690-8504, Japan.
[Ti] Título:2,4-Dichlorophenoxyacetic acid (2,4-D)- and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)-degrading gene cluster in the soybean root-nodulating bacterium Bradyrhizobium elkanii USDA94.
[So] Source:Microbiol Res;188-189:62-71, 2016 Jul-Aug.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Herbicides 2,4-dichlorophenoxyacetic acid (2,4-D)- and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)-degrading Bradyrhizobium strains possess tfdAα and/or cadABC as degrading genes. It has been reported that root-nodulating bacteria belonging to Bradyrhizobium elkanii also have tfdAα and cadA like genes but lack the ability to degrade these herbicides and that the cadA genes in 2,4-D-degrading and non-degrading Bradyrhizobium are phylogenetically different. In this study, we identified cadRABCK in the genome of a type strain of soybean root-nodulating B. elkanii USDA94 and demonstrated that the strain could degrade the herbicides when cadABCK was forcibly expressed. cadABCK-cloned Escherichia coli also showed the degrading ability. Because co-spiked phenoxyacetic acid (PAA) could induce the degradation of 2,4-D in B. elkanii USDA94, the lack of degrading ability in this strain was supposed to be due to the low inducing potential of the herbicides for the degrading gene cluster. On the other hand, tfdAα from B. elkanii USDA94 showed little potential to degrade the herbicides, but it did for 4-chlorophenoxyacetic acid and PAA. The 2,4-D-degrading ability of the cad cluster and the inducing ability of PAA were confirmed by preparing cadA deletion mutant. This is the first study to demonstrate that the cad cluster in the typical root-nodulating bacterium indeed have the potential to degrade the herbicides, suggesting that degrading genes for anthropogenic compounds could be found in ordinary non-degrading bacteria.
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/metabolismo
Ácido 2,4-Diclorofenoxiacético/metabolismo
Bradyrhizobium/metabolismo
Herbicidas/metabolismo
Família Multigênica
Raízes de Plantas/microbiologia
Feijão de Soja/microbiologia
[Mh] Termos MeSH secundário: Acetatos/metabolismo
Biotransformação
Bradyrhizobium/genética
Bradyrhizobium/isolamento & purificação
Clonagem Molecular
Escherichia coli/genética
Escherichia coli/metabolismo
Deleção de Genes
Expressão Gênica
Genes Bacterianos
Ativação Transcricional/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Herbicides); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid); YRC253429Q (phenoxyacetic acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


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[PMID]:27196847
[Au] Autor:Schmidt C
[Ti] Título:The Fog of Agent Orange.
[So] Source:Sci Am;314(6):70-5, 2016 Jun.
[Is] ISSN:0036-8733
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/toxicidade
Ácido 2,4-Diclorofenoxiacético/toxicidade
Anormalidades Induzidas por Medicamentos/etiologia
Dibenzodioxinas Policloradas/toxicidade
Guerra do Vietnã
[Mh] Termos MeSH secundário: Anormalidades Induzidas por Medicamentos/epidemiologia
Anormalidades Induzidas por Medicamentos/genética
Agente Laranja
Animais
Criança
Dano ao DNA
Desfolhantes Químicos
Dioxinas/toxicidade
Epigênese Genética
Feminino
Seres Humanos
Masculino
Gravidez
Estados Unidos
Vietnã/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Defoliants, Chemical); 0 (Dioxins); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE
[do] DOI:10.1038/scientificamerican0616-70


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[PMID]:27035455
[Au] Autor:Gunderson CH; Daroff RB
[Ti] Título:Neurology in the Vietnam War.
[So] Source:Front Neurol Neurosci;38:201-13, 2016.
[Is] ISSN:1662-2804
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Between December 1965 and December 1971, the United States maintained armed forces in Vietnam never less than 180,000 men and women in support of the war. At one time, this commitment exceeded half a million soldiers, sailors, and airmen from both the United States and its allies. Such forces required an extensive medical presence, including 19 neurologists. All but two of the neurologists had been drafted for a 2-year tour of duty after deferment for residency training. They were assigned to Vietnam for one of those 2 years in two Army Medical Units and one Air Force facility providing neurological care for American and allied forces, as well as many civilians. Their practice included exposure to unfamiliar disorders including cerebral malaria, Japanese B encephalitis, sleep deprivation seizures, and toxic encephalitis caused by injection or inhalation of C-4 explosive. They and neurologists at facilities in the United States published studies on all of these entities both during and after the war. These publications spawned the Defense and Veterans Head Injury Study, which was conceived during the Korean War and continues today as the Defense and Veterans Head Injury Center. It initially focused on post-traumatic epilepsy and later on all effects of brain injury. The Agent Orange controversy arose after the war; during the war, it was not perceived as a threat by medical personnel. Although soldiers in previous wars had developed serious psychological impairments, post-traumatic stress disorder was formally recognized in the servicemen returning from Vietnam.
[Mh] Termos MeSH primário: Distúrbios de Guerra
Medicina Militar/história
Neurologia/história
Veteranos/história
Guerra do Vietnã
[Mh] Termos MeSH secundário: Ácido 2,4,5-Triclorofenoxiacético/história
Ácido 2,4,5-Triclorofenoxiacético/toxicidade
Ácido 2,4-Diclorofenoxiacético/história
Ácido 2,4-Diclorofenoxiacético/toxicidade
Agente Laranja
Distúrbios de Guerra/história
Distúrbios de Guerra/terapia
História do Século XX
Seres Humanos
Dibenzodioxinas Policloradas/história
Dibenzodioxinas Policloradas/toxicidade
Transtornos de Estresse Pós-Traumáticos/história
Vietnã
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Nm] Nome de substância:
0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE
[do] DOI:10.1159/000442657


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[PMID]:26923711
[Au] Autor:Beard JD; Engel LS; Richardson DB; Gammon MD; Baird C; Umbach DM; Allen KD; Stanwyck CL; Keller J; Sandler DP; Schmidt S; Kamel F
[Ad] Endereço:Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
[Ti] Título:Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis etiology.
[So] Source:Environ Int;91:104-15, 2016 May.
[Is] ISSN:1873-6750
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Factors underlying a possible excess of amyotrophic lateral sclerosis (ALS) among military veterans remain unidentified. Limitations of previous studies on this topic include reliance on ALS mortality as a surrogate for ALS incidence, low statistical power, and sparse information on military-related factors. OBJECTIVES: We evaluated associations between military-related factors and ALS using data from a case-control study of U.S. military veterans. METHODS: From 2005 to 2010, we identified medical record-confirmed ALS cases via the National Registry of Veterans with ALS and controls via the Veterans Benefits Administration's Beneficiary Identification and Records Locator System database. In total, we enrolled 621 cases and 958 frequency-matched controls in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study. We collected information on military service and deployments and 39 related exposures. We used unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). We used inverse probability weighting to adjust for potential bias from confounding, missing covariate data, and selection arising from a case group that disproportionately included long-term survivors and a control group that may or may not differ from U.S. military veterans at large. RESULTS: The odds of ALS did not differ for veterans of the Air Force, Army, Marines, and Navy. We found higher odds of ALS for veterans whose longest deployment was World War II or the Korean War and a positive trend with total years of all deployments (OR=1.27; 95% CI: 1.06, 1.52). ALS was positively associated with exposure to herbicides for military purposes, nasopharyngeal radium, personal pesticides, exhaust from heaters or generators, high-intensity radar waves, contaminated food, explosions within one mile, herbicides in the field, mixing and application of burning agents, burning agents in the field, and Agent Orange in the field, with ORs between 1.50 and 7.75. CONCLUSIONS: Although our results need confirmation, they are potentially important given the large number of U.S. military veterans, and they provide clues to potential factors underlying the apparent increase of ALS in veteran populations.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/epidemiologia
Exposição Ambiental
Militares/estatística & dados numéricos
Veteranos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Ácido 2,4,5-Triclorofenoxiacético
Ácido 2,4-Diclorofenoxiacético
Adulto
Idoso
Agente Laranja
Estudos de Casos e Controles
Feminino
Seres Humanos
Incidência
Modelos Logísticos
Masculino
Meia-Idade
Razão de Chances
Praguicidas
Dibenzodioxinas Policloradas
Rádio (Elemento)
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Pesticides); 0 (Polychlorinated Dibenzodioxins); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid); W90AYD6R3Q (Radium)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160301
[St] Status:MEDLINE


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[PMID]:26758301
[Au] Autor:Sun XL; Kido T; Honma S; Okamoto R; Manh HD; Maruzeni S; Nishijo M; Nakagawa H; Nakano T; Koh E; Takasuga T; Nhu DD; Hung NN; Son le K
[Ad] Endereço:Department of Public Health, School of Medicine, Jiaxing University, Jiaxing, China.
[Ti] Título:Influence of dioxin exposure upon levels of prostate-specific antigen and steroid hormones in Vietnamese men.
[So] Source:Environ Sci Pollut Res Int;23(8):7807-13, 2016 Apr.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Most studies on the relationship between Agent Orange and prostate cancer have focused on US veterans of the Vietnam War. There have been few studies focusing on the relationship between levels of prostate-specific antigen (PSA) and dioxins or steroid hormones in Vietnamese men. In 2009-2011, we collected blood samples from 97 men who had resided in a "dioxin hotspot" and 85 men from a non-sprayed region in Vietnam. Then levels of PSA, dioxins, and steroid hormones were analyzed. Levels of most dioxins, furans, and non-ortho polychlorinated biphenyls were higher in the hotspot than those in the non-sprayed region. Levels of testosterone, dehydroepiandrosterone, and estradiol differed significantly between the hotspot and the non-sprayed region, but there were no correlations between levels of PSA and steroid hormones and dioxins in either of the two regions. Our findings suggest that PSA levels in Vietnamese men are not associated with levels of dioxin or steroid hormones in these two regions.
[Mh] Termos MeSH primário: Ácido 2,4,5-Triclorofenoxiacético/toxicidade
Ácido 2,4-Diclorofenoxiacético/toxicidade
Poluentes Ambientais/toxicidade
Hormônios Esteroides Gonadais/sangue
Dibenzodioxinas Policloradas/toxicidade
Antígeno Prostático Específico/sangue
[Mh] Termos MeSH secundário: Ácido 2,4,5-Triclorofenoxiacético/análise
Ácido 2,4-Diclorofenoxiacético/análise
Idoso
Agente Laranja
Benzofuranos
Dioxinas
Poluentes Ambientais/análise
Furanos/análise
Seres Humanos
Masculino
Meia-Idade
Bifenilos Policlorados/análise
Neoplasias da Próstata
Esteroides
Testosterona
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (Dioxins); 0 (Environmental Pollutants); 0 (Furans); 0 (Gonadal Steroid Hormones); 0 (Polychlorinated Dibenzodioxins); 0 (Steroids); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 39277-47-9 (Agent Orange); 3XMK78S47O (Testosterone); 9Q963S4YMX (2,4,5-Trichlorophenoxyacetic Acid); DFC2HB4I0K (Polychlorinated Biphenyls); EC 3.4.21.77 (Prostate-Specific Antigen)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160114
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-015-5931-3



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