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[PMID]:28449861
[Au] Autor:Herbert A; Edwards JH; Jones GL; Ingham E; Fisher J
[Ad] Endereço:(IMBE) Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK. Electronic address: A.Herbert@leeds.ac.uk.
[Ti] Título:The effects of irradiation dose and storage time following treatment on the viscoelastic properties of decellularised porcine super flexor tendon.
[So] Source:J Biomech;57:157-160, 2017 05 24.
[Is] ISSN:1873-2380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Decellularised porcine super flexor tendon (pSFT) offers a promising solution to the replacement of damaged anterior cruciate ligament. It is desirable to package and terminally sterilise the acellular grafts to eliminate any possible harmful pathogens. However, irradiation techniques can damage the collagen structure and consequently reduce the mechanical properties. The aims of this study were to investigate the effects of irradiation sterilisation of varying dosages on the viscoelastic properties of the decellularised pSFT. Decellularised pSFT tendons were subjected to irradiation sterilisation using either 30kGygamma, 55kGygamma, 34kGy E-beam, 15kGygamma, 15kGy E-beam and (15+15) kGy E-beam (fractionated dose). Specimens then underwent stress relaxation testing at 0 and 12months post sterilisation to determine whether any effect on the viscoelastic properties was progressive. Significant differences were found which demonstrated that all irradiation treatments had an effect on the time-independent and time-dependent viscoelastic properties of irradiated tendons compared to peracetic acid only treated controls. No significant differences were found between the irradiated groups and no significant differences were found between groups at 0 and 12months. These results indicate the decellularised pSFT graft has a stable shelf-life.
[Mh] Termos MeSH primário: Esterilização/métodos
Tendões
[Mh] Termos MeSH secundário: Animais
Elasticidade
Feminino
Ácido Peracético/farmacologia
Dose de Radiação
Manejo de Espécimes
Estresse Mecânico
Suínos
Tendões/efeitos dos fármacos
Tendões/fisiologia
Tendões/efeitos da radiação
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180120
[Lr] Data última revisão:
180120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29065168
[Au] Autor:Black E; Owens K; Staub R; Li J; Mills K; Valenstein J; Hilgren J
[Ad] Endereço:Ecolab Research, Development and Engineering Center, Eagan, Minnesota, United States of America.
[Ti] Título:Evaluation of AISI Type 304 stainless steel as a suitable surface material for evaluating the efficacy of peracetic acid-based disinfectants against Clostridium difficile spores.
[So] Source:PLoS One;12(10):e0187074, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Disinfectants play an important role in controlling microbial contamination on hard surfaces in hospitals. The effectiveness of disinfectants in real life can be predicted by laboratory tests that measure killing of microbes on carriers. The modified Quantitative Disk Carrier Test (QCT-2) is a standard laboratory method that employs American Iron and Steel Institute (AISI) Type 430 stainless steel carriers to measure hospital disinfectant efficacy against Clostridium difficile spores. The formation of a rust-colored precipitate was observed on Type 430 carriers when testing a peracetic acid (PAA)-based disinfectant with the QCT-2 method. It was hypothesized that the precipitate was indicative of corrosion of the Type 430 carrier, and that corrosion could impact efficacy results. The objective of this study was to compare the suitability of AISI Type 430 to Type 304 stainless steel carriers for evaluating PAA-based disinfectants using the QCT-2 method. Type 304 is more corrosion-resistant than Type 430, is ubiquitous in healthcare environments, and is used in other standard methods. Suitability of the carriers was evaluated by comparing their impacts on efficacy results and PAA degradation rates. In efficacy tests with 1376 ppm PAA, reductions of C. difficile spores after 5, 7 and 10 minutes on Type 430 carriers were at least about 1.5 log10 lower than reductions on Type 304 carriers. In conditions simulating a QCT-2 test, PAA concentration with Type 430 carriers was reduced by approximately 80% in 10 minutes, whereas PAA concentration in the presence of Type 304 carriers remained stable. Elemental analyses of residues on each carrier type after efficacy testing were indicative of corrosion on the Type 430 carrier. Use of Type 430 stainless steel carriers for measuring the efficacy of PAA-based disinfectants should be avoided as it can lead to an underestimation of real life sporicidal efficacy. Type 304 stainless steel carriers are recommended as a suitable alternative.
[Mh] Termos MeSH primário: Clostridium difficile/crescimento & desenvolvimento
Desinfetantes/farmacologia
Ácido Peracético/farmacologia
Esporos Bacterianos/efeitos dos fármacos
Aço Inoxidável
[Mh] Termos MeSH secundário: Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 12597-68-1 (Stainless Steel); I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187074


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[PMID]:28782995
[Au] Autor:Sreedharan A; Li Y; De J; Gutierrez A; Silverberg R; Schneider KR
[Ad] Endereço:Department of Food Science and Human Nutrition, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida 32611, USA.
[Ti] Título:Determination of Optimum Sanitizer Levels for Prevention of Salmonella Cross-Contamination of Mature Round Tomatoes in a Laboratory Model Flume System.
[So] Source:J Food Prot;80(9):1436-1442, 2017 Sep.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Salmonella has been reported to be involved in several foodborne illness outbreaks, many of which resulted from consumption of raw tomatoes. This research aimed to optimize and evaluate the concentration of free chlorine (hypochlorous acid [HOCl]) used as a sanitizer to prevent cross-contamination of tomatoes inoculated with a cocktail of five rifampin-resistant Salmonella enterica serovars in a laboratory-based model flume system. Organic load, prepared using sterilized Scotts Premium Topsoil, was added in different quantities to the flume wash water to simulate real-world packinghouse conditions. In a typical packinghouse operation utilizing a recirculating flume system, the organic matter washed from tomato surfaces accumulates over time. In this study, different concentrations (0, 25, 50, 75, and 100 ppm) of HOCl were used as sanitizers under three organic load conditions (0, 650, and 1,000 mg/L chemical oxygen demand). Results showed that 100 ppm of HOCl was necessary to prevent Salmonella cross-contamination of uninoculated tomatoes in the model flume system in the presence of organic loading. Also, when treated with 100 ppm of HOCl, Salmonella levels were reduced by >4.5 log CFU per tomato from inoculated tomatoes in the presence of organic load. At 75 ppm of HOCl, Salmonella cross-contamination was prevented, but only in the absence of organic loading. In studies in which plate counts were negative, whole tomato enrichment studies were performed. No cross-contamination of uninoculated tomatoes was recorded when 100 ppm of HOCl was used, even in the presence of high organic load (1,000 mg/L chemical oxygen demand). Although sanitizer application reduces contamination on tomato surfaces, the primary function of sanitizers in the wash water is to prevent cross-contamination.
[Mh] Termos MeSH primário: Desinfetantes/farmacologia
Contaminação de Alimentos/prevenção & controle
Lycopersicon esculentum/microbiologia
Salmonella/efeitos dos fármacos
Salmonella/isolamento & purificação
[Mh] Termos MeSH secundário: Contagem de Colônia Microbiana
Manipulação de Alimentos
Microbiologia de Alimentos
Ácido Peracético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-17-032


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[PMID]:28667013
[Au] Autor:Dornevil K; Davis I; Fielding AJ; Terrell JR; Ma L; Liu A
[Ad] Endereço:From the Department of Chemistry, University of Texas, San Antonio, Texas 78249 and.
[Ti] Título:Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from proceeds through a catalytic shunt pathway.
[So] Source:J Biol Chem;292(33):13645-13657, 2017 Aug 18.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CYP121, the cytochrome P450 enzyme in that catalyzes a single intramolecular C-C cross-linking reaction in the biosynthesis of mycocyclosin, is crucial for the viability of this pathogen. This C-C coupling reaction represents an expansion of the activities carried out by P450 enzymes distinct from oxygen insertion. Although the traditional mechanism for P450 enzymes has been well studied, it is unclear whether CYP121 follows the general P450 mechanism or uses a different catalytic strategy for generating an iron-bound oxidant. To gain mechanistic insight into the CYP121-catalyzed reaction, we tested the peroxide shunt pathway by using rapid kinetic techniques to monitor the enzyme activity with its substrate dicyclotyrosine (cYY) and observed the formation of the cross-linked product mycocyclosin by LC-MS. In stopped-flow experiments, we observed that cYY binding to CYP121 proceeds in a two-step process, and EPR spectroscopy indicates that the binding induces active site reorganization and uniformity. Using rapid freeze-quenching EPR, we observed the formation of a high-spin intermediate upon the addition of peracetic acid to the enzyme-substrate complex. This intermediate exhibits a high-spin ( = 5/2) signal with g values of 2.00, 5.77, and 6.87. Likewise, iodosylbenzene could also produce mycocyclosin, implicating compound I as the initial oxidizing species. Moreover, we also demonstrated that CYP121 performs a standard peroxidase type of reaction by observing substrate-based radicals. On the basis of these results, we propose plausible free radical-based mechanisms for the C-C bond coupling reaction.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
Dipeptídeos/metabolismo
Mycobacterium tuberculosis/enzimologia
Peptídeos Cíclicos/metabolismo
Tirosina/análogos & derivados
[Mh] Termos MeSH secundário: Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Biocatálise
Domínio Catalítico
Cromatografia Líquida de Alta Pressão
Sistema Enzimático do Citocromo P-450/química
Sistema Enzimático do Citocromo P-450/genética
Dicetopiperazinas/química
Dicetopiperazinas/metabolismo
Dipeptídeos/química
Espectroscopia de Ressonância de Spin Eletrônica
Iodobenzenos/farmacologia
Cinética
Ligantes
Espectrometria de Massas
Estrutura Molecular
Oxidantes/farmacologia
Oxirredução
Peptídeos Cíclicos/química
Ácido Peracético/farmacologia
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Espectrofotometria
Especificidade por Substrato
Tirosina/química
Tirosina/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Diketopiperazines); 0 (Dipeptides); 0 (Iodobenzenes); 0 (Ligands); 0 (Oxidants); 0 (Peptides, Cyclic); 0 (Recombinant Proteins); 0 (cytochrome P-450 CYP121); 0 (mycocyclosin); 42HK56048U (Tyrosine); 5625-40-1 (cyclo(tyrosyl-tyrosyl)); 9035-51-2 (Cytochrome P-450 Enzyme System); I6KPI2E1HD (Peracetic Acid); TWW7V7Q50P (iodosobenzene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.794099


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[PMID]:28662397
[Au] Autor:Zhang K; Zhou X; Du P; Zhang T; Cai M; Sun P; Huang CH
[Ad] Endereço:College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310058, People's Republic of China; School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, United States.
[Ti] Título:Oxidation of ß-lactam antibiotics by peracetic acid: Reaction kinetics, product and pathway evaluation.
[So] Source:Water Res;123:153-161, 2017 Oct 15.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Peracetic acid (PAA) is a disinfection oxidant used in many industries including wastewater treatment. ß-Lactams, a group of widely prescribed antibiotics, are frequently detected in wastewater effluents and surface waters. The reaction kinetics and transformation of seven ß-lactams (cefalexin (CFX), cefadroxil (CFR), cefapirin (CFP), cephalothin (CFT), ampicillin (AMP), amoxicillin (AMX) and penicillin G (PG)) toward PAA were investigated to elucidate the behavior of ß-lactams during PAA oxidation processes. The reaction follows second-order kinetics and is much faster at pH 5 and 7 than at pH 9 due to speciation of PAA. Reactivity to PAA follows the order of CFR âˆ¼ CFX > AMP âˆ¼ AMX > CFT âˆ¼ CFP âˆ¼ PG and is related to ß-lactam's nucleophilicity. The thioether sulfur of ß-lactams is attacked by PAA to generate sulfoxide products. Presence of the phenylglycinyl amino group on ß-lactams can significantly influence electron distribution and the highest occupied molecular orbital (HOMO) location and energy in ways that enhance the reactivity to PAA. Reaction rate constants obtained in clean water matrix can be used to accurately model the decay of ß-lactams by PAA in surface water matrix and only slightly overestimate the decay in wastewater matrix. Results of this study indicate that the oxidative transformation of ß-lactams by PAA can be expected under appropriate wastewater treatment conditions.
[Mh] Termos MeSH primário: Antibacterianos
Águas Residuais
beta-Lactamas/metabolismo
[Mh] Termos MeSH secundário: Cinética
Ácido Peracético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Waste Water); 0 (beta-Lactams); I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE


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Silva, Vinicius Duval da
Texto completo SciELO Brasil
[PMID]:28513789
[Au] Autor:Baldasso FER; Roleto L; Silva VDD; Morgental RD; Kopper PMP
[Ad] Endereço:Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Conservative Dentistry, Porto Alegre, RS, Brazil.
[Ti] Título:Effect of final irrigation protocols on microhardness reduction and erosion of root canal dentin.
[So] Source:Braz Oral Res;31:e40, 2017 May 15.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the effect of final irrigation protocols on microhardness reduction and erosion of root canal dentin. Sixty root canals from mandibular incisors were instrumented and randomly divided into six groups (n = 10) according to the irrigant used: QMiX, 17% EDTA, 10% citric acid (CA), 1% peracetic acid (PA), 2.5% NaOCl (solution control), and distilled water (negative control). The chelating solutions were used to irrigate the canal followed by 2.5% NaOCl as a final flush. After the irrigation protocols, all specimens were rinsed with 10 mL of distilled water to remove any residue of the chemical solutions. Before and after the final irrigation protocols, dentin microhardness was measured with a Knoop indenter. Three indentations were made at 100 µm and 500 µm from the root canal lumen. Afterwards, the specimens were prepared for scanning electron microscopic analysis and the amount of dentin erosion was examined. Wilcoxon and Kruskal-Wallis tests were used to analyze the results with a significance level set at 5%. At 100 µm, all protocols significantly reduced dentin microhardness (p < .05), while at 500 µm, this effect was detected only in the EDTA and QMiX groups (p < .05). CA was the irrigant that caused more extensive erosion in dentinal tubules, followed by PA and EDTA. QMiX opened dentinal tubules, but did not cause dentin erosion. Results suggest that QMiX and 17% EDTA reduced dentin microhardness at a greater depth. Additionally, QMiX did not cause dentin erosion.
[Mh] Termos MeSH primário: Cavidade Pulpar/efeitos dos fármacos
Dentina/efeitos dos fármacos
Irrigantes do Canal Radicular
Erosão Dentária/induzido quimicamente
[Mh] Termos MeSH secundário: Biguanidas
Ácido Cítrico/farmacologia
Dentina/ultraestrutura
Ácido Edético/farmacologia
Testes de Dureza
Seres Humanos
Teste de Materiais
Microscopia Eletrônica de Varredura
Ácido Peracético/farmacologia
Polímeros
Distribuição Aleatória
Reprodutibilidade dos Testes
Tratamento do Canal Radicular/métodos
Camada de Esfregaço
Hipoclorito de Sódio/farmacologia
Estatísticas não Paramétricas
Propriedades de Superfície/efeitos dos fármacos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biguanides); 0 (Polymers); 0 (QMix root canal irrigant); 0 (Root Canal Irrigants); 2968PHW8QP (Citric Acid); 9G34HU7RV0 (Edetic Acid); DY38VHM5OD (Sodium Hypochlorite); I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


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[PMID]:28415482
[Au] Autor:Pellegata AF; Bottagisio M; Boschetti F; Ferroni M; Bortolin M; Drago L; Lovati AB
[Ad] Endereço:Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
[Ti] Título:Terminal sterilization of equine-derived decellularized tendons for clinical use.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:43-49, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the last few years, the demand for tissue substitutes has increased and decellularized matrices has been widely proposed in the medical field to restore severe damages thanks to high biocompatibility and biomechanical properties similar to the native tissues. However, biological grafts represent a potential source of contamination and disease transmission; thus, there is the need to achieve acceptable levels of sterility. Several sterilization methods have been investigated with no consensus on the outcomes in terms of minimizing structural damages and preserving functional features of the decellularized matrix for transplantation in humans. With the aim of making decellularized tendons safe for clinical use, we evaluated the cytocompatibility, and biochemical, structural and biomechanical variations of decellularized equine tendons sterilized with peracetic acid or ß-irradiation and differently wet- or dry- stored at 4°C or -80°C, respectively. Considering that both sterilization and long-term storage are crucial steps that could not be avoided, our results pointed at ionizing ß-rays as terminal sterilization method for decellularized grafts followed by frozen dry storage. Indeed, this approach can maintain the integrity of collagen-based structures and can avoid biomechanical changes, thus making xenogeneic decellularized tendons a promising candidate for clinical use.
[Mh] Termos MeSH primário: Ácido Peracético/química
Esterilização/métodos
Tendões/química
[Mh] Termos MeSH secundário: Animais
Partículas beta
Cavalos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28319888
[Au] Autor:Zhao X; Gao T; Zhang J
[Ad] Endereço:State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China.
[Ti] Título:Heterogeneous reaction of peroxyacetyl nitrate (PAN) on soot.
[So] Source:Chemosphere;177:339-346, 2017 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The interaction between photochemical oxidants and aerosol particles has been examined in previous atmospheric pollution studies. The heterogeneous reaction can affect the concentration of gases and free radicals, as well as the morphology and properties of particles. In this report, the interaction between the photochemical oxidant peroxyacetyl nitrate (PAN) and soot particles was investigated using a flow tube system. We used real-time online monitoring equipment to track changes in PAN concentrations. Substances on the soot surface were detected using ion chromatography (IC), x-ray photoelectron spectroscopy (XPS), and other surface analysis methods. At 295 K, the upper and lower limits of the initial uptake coefficients were 1.28 × 10 and 9.16 × 10 , respectively. The heterogeneous reaction of PAN on soot was a first-order reaction to PAN under both dry and wet conditions. The products formed on soot included CH COO , HCOO , NO , and NO . With an increase in relative humidity, the production of all species decreased and the relative amounts changed.
[Mh] Termos MeSH primário: Aerossóis/análise
Oxidantes Fotoquímicos/análise
Ácido Peracético/análogos & derivados
Fuligem/análise
[Mh] Termos MeSH secundário: Cromatografia por Troca Iônica
Gases/análise
Íons
Nitrogênio/química
Ácido Peracético/análise
Espectrometria por Raios X
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Gases); 0 (Ions); 0 (Oxidants, Photochemical); 0 (Soot); I6KPI2E1HD (Peracetic Acid); N762921K75 (Nitrogen); SQ8V0P4N89 (peroxyacetyl nitrate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28237883
[Au] Autor:Davidson GR; Kaminski-Davidson CN; Ryser ET
[Ad] Endereço:Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:Persistence of Escherichia coli O157:H7 during pilot-scale processing of iceberg lettuce using flume water containing peroxyacetic acid-based sanitizers and various organic loads.
[So] Source:Int J Food Microbiol;248:22-31, 2017 May 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In order to minimize cross-contamination during leafy green processing, chemical sanitizers are routinely added to the wash water. This study assessed the efficacy of peroxyacetic acid and mixed peracid against E. coli O157:H7 on iceberg lettuce, in wash water, and on equipment during simulated commercial production in a pilot-scale processing line using flume water containing various organic loads. Iceberg lettuce (5.4kg) inoculated to contain 10 CFU/g of a 4-strain cocktail of non-toxigenic, GFP-labeled, ampicillin-resistant E. coli O157:H7, was shredded using a commercial shredder, step-conveyed to a flume tank, washed for 90s using water alone or two different sanitizing treatments (50ppm peroxyacetic acid or mixed peracid) in water containing organic loads of 0, 2.5, 5 or 10% (w/v) blended iceberg lettuce, and then dried using a shaker table and centrifugal dryer. Thereafter, three 5.4-kg batches of uninoculated iceberg lettuce were identically processed. Various product (25g) and water (50ml) samples collected during processing along with equipment surface samples (100cm ) from the flume tank, shaker table and centrifugal dryer were then assessed for numbers of E. coli O157:H7. Organic load rarely impacted (P>0.05) the efficacy of either peroxyacetic acid or mixed peracid, with typical reductions of >5logCFU/ml in wash water throughout processing for all organic loads. Increases in organic load in the wash water corresponded to changes in total solids, chemical oxygen demand, turbidity, maximum filterable volume, and oxidation/reduction potential. After 90s of exposure to flume water, E. coli O157:H7 reductions on inoculated lettuce ranged from 0.97 to 1.74logCFU/g using peroxyacetic acid, with an average reduction of 1.35logCFU/g for mixed peracid. E. coli O157:H7 persisted on all previously uninoculated lettuce following the inoculated batch, emphasizing the need for improved intervention strategies that can better ensure end-product safety.
[Mh] Termos MeSH primário: Desinfetantes/farmacologia
Escherichia coli O157/isolamento & purificação
Contaminação de Alimentos/análise
Manipulação de Alimentos/métodos
Alface/microbiologia
Ácido Peracético/farmacologia
[Mh] Termos MeSH secundário: Ampicilina/farmacologia
Contagem de Colônia Microbiana
Farmacorresistência Bacteriana
Escherichia coli O157/efeitos dos fármacos
Contaminação de Alimentos/prevenção & controle
Manipulação de Alimentos/instrumentação
Microbiologia de Alimentos
Folhas de Planta/microbiologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 059QF0KO0R (Water); 7C782967RD (Ampicillin); I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


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[PMID]:28192222
[Au] Autor:Ayoub F; Ben Oujji N; Chebli B; Ayoub M; Hafidi A; Salghi R; Jodeh S
[Ad] Endereço:Laboratory of Applied Chemistry and Environment, National School of Applied Science, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco. Electronic address: ayoub.fatima@gmail.com.
[Ti] Título:Antifungal effectiveness of fungicide and peroxyacetic acid mixture on the growth of Botrytis cinerea.
[So] Source:Microb Pathog;105:74-80, 2017 Apr.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the attempt to reduce the negative impacts of chemical pesticides on environment and consumer's health, a new plant treatment practice minimizing the amount of pesticides needed during pests and diseases treatments has been developed. Our approach is based on combining the biocide effects of fungicide with the peroxyacetic acid (PAA) one. In this paper, we focused on the in vitro study of the antifungal activity of this combination against Botrytis cinerea, the most redoubtable threat of tomatoes plants in Morocco. First, different concentrations of a peroxyacetic acid product (PERACLEAN 5) and two commercially available fungicides SWITCH and SIGNUM were tested separately for their inhibitory effects on the mycelial growth and spores germination of B. cinerea. 100% inhibition of fungal growth was achieved using 16.77 and 14.47 µg/ml of SIGNUM and SWITCH respectively and 1.5% of PERACLEAN 5. When combined with 0.5% of the peroxyacetic acid mixture (PERACLEAN 5), the pesticides 100% effective concentrations decreased to 0.5 µg/ml for both pesticides. Hence, this approach allowed us to suppress the pathogen while minimizing the amounts of applied fungicides by more than 95%.
[Mh] Termos MeSH primário: Botrytis/efeitos dos fármacos
Botrytis/crescimento & desenvolvimento
Sinergismo Farmacológico
Fungicidas Industriais/farmacologia
Ácido Peracético/farmacologia
[Mh] Termos MeSH secundário: Lycopersicon esculentum/microbiologia
Marrocos
Micélio/efeitos dos fármacos
Micélio/crescimento & desenvolvimento
Doenças das Plantas/microbiologia
Esporos Fúngicos/efeitos dos fármacos
Esporos Fúngicos/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); I6KPI2E1HD (Peracetic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE



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