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[PMID]:28461448
[Au] Autor:Borchert AJ; Downs DM
[Ad] Endereço:Department of Microbiology, University of Georgia, Athens, Georgia, USA.
[Ti] Título:The Response to 2-Aminoacrylate Differs in Escherichia coli and Salmonella enterica, despite Shared Metabolic Components.
[So] Source:J Bacteriol;199(14), 2017 07 15.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The metabolic network of an organism includes the sum total of the biochemical reactions present. In microbes, this network has an impeccable ability to sense and respond to perturbations caused by internal or external stimuli. The metabolic potential (i.e., network structure) of an organism is often drawn from the genome sequence, based on the presence of enzymes deemed to indicate specific pathways. and are members of the family of Gram-negative bacteria that share the majority of their metabolic components and regulatory machinery as the "core genome." In , the ability of the enamine intermediate 2-aminoacrylate (2AA) to inactivate a number of pyridoxal 5'-phosphate (PLP)-dependent enzymes has been established In this study, 2AA metabolism and the consequences of its accumulation were investigated in The data showed that despite the conservation of all relevant enzymes, and differed in both the generation and detrimental consequences of 2AA. In total, these findings suggest that the structure of the metabolic network surrounding the generation and response to endogenous 2AA stress differs between and This work compared the metabolic networks surrounding the endogenous stressor 2-aminoacrylate in two closely related members of the The data showed that despite the conservation of all relevant enzymes in this metabolic node, the two closely related organisms diverged in their metabolic network structures. This work highlights how a set of conserved components can generate distinct network architectures and how this can impact the physiology of an organism. This work defines a model to expand our understanding of the 2-aminoacrylate stress response and the differences in metabolic structures and cellular milieus between and .
[Mh] Termos MeSH primário: Acrilatos/farmacologia
Proteínas de Bactérias/metabolismo
Escherichia coli/efeitos dos fármacos
Salmonella enterica/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adenina/farmacologia
Ácido Aspártico/farmacologia
Proteínas de Bactérias/genética
Escherichia coli/metabolismo
Deleção de Genes
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Regulação Enzimológica da Expressão Gênica/fisiologia
L-Serina Desidratase/genética
L-Serina Desidratase/metabolismo
Salmonella enterica/metabolismo
Estresse Fisiológico/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Acrylates); 0 (Bacterial Proteins); 30KYC7MIAI (Aspartic Acid); EC 4.3.1.17 (L-Serine Dehydratase); JAC85A2161 (Adenine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29465569
[Au] Autor:Kang MJ; Joo CK
[Ad] Endereço:Department of Ophthalmology and Catholic Institute for Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
[Ti] Título:Three cases of a torn haptic after scleral fixation using a hydrophobic acrylic intraocular lens: Case reports.
[So] Source:Medicine (Baltimore);97(8):e9853, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report 3 cases of a torn haptic after successful scleral fixation with a hydrophobic acrylic intraocular lens. PATIENT CONCERNS: Patients complained of decreased visual acuity about 1 week to 1 month after scleral fixation. DIAGNOSES: In all 3 cases, the direction of the damaged haptic correlated with the direction of the pulling force made by the hung suture material. Observation of a cheese-wiring effect on scanning electron microscopy suggested that the haptic was cut by the suture. INTERVENTIONS: Patients underwent re-scleral fixation with caution. OUCTOMES: There was no complication of broken haptic after re-scleral fixation. LESSONS: To avoid unexpected haptic tears, great caution is needed; surgeons should avoid applying excessive pulling force to the intraocular lens when performing scleral fixation using a hydrophobic acrylic intraocular lens.
[Mh] Termos MeSH primário: Implante de Lente Intraocular/métodos
Lentes Intraoculares
Esclera/cirurgia
[Mh] Termos MeSH secundário: Acrilatos
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Complicações Pós-Operatórias
Reoperação
Técnicas de Sutura
Transtornos da Visão/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009853


  3 / 7449 MEDLINE  
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[PMID]:27779357
[Au] Autor:Venturato A; MacFarlane G; Geng J; Bradley M
[Ad] Endereço:School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, EH9 3KJ, UK.
[Ti] Título:Understanding Polymer-Cell Attachment.
[So] Source:Macromol Biosci;16(12):1864-1872, 2016 12.
[Is] ISSN:1616-5195
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The development of polymeric materials with cell adhesion abilities requires an understanding of cell-surface interactions which vary with cell type. To investigate the correlation between cell attachment and the nature of the polymer, a series of random and block copolymers composed of 2-(dimethylamino)ethyl acrylate and ethyl acrylate are synthesized through single electron transfer living radical polymerization. The polymers are synthesized with highly defined and controlled monomer compositions and exhibited narrow polydispersity indices. These polymers are examined for their performance in the attachment and growth of HeLa and HEK cells, with attachment successfully modeled on monomer composition and polymer chain length, with both cell lines found to preferentially attach to moderately hydrophobic functional materials. The understanding of the biological-material interactions assessed in this study will underpin further investigations of engineered polymer scaffolds with predictable cell binding performance.
[Mh] Termos MeSH primário: Acrilatos/química
Adesão Celular/fisiologia
Metilaminas/química
Polímeros/química
Polímeros/metabolismo
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/química
Materiais Biocompatíveis/metabolismo
Células HEK293
Células HeLa
Seres Humanos
Polimerização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-(dimethylamino ethyl)acrylate); 0 (Acrylates); 0 (Biocompatible Materials); 0 (Methylamines); 0 (Polymers); 71E6178C9T (ethyl acrylate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1002/mabi.201600253


  4 / 7449 MEDLINE  
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[PMID]:28812582
[Au] Autor:Schell JC; Wisidagama DR; Bensard C; Zhao H; Wei P; Tanner J; Flores A; Mohlman J; Sorensen LK; Earl CS; Olson KA; Miao R; Waller TC; Delker D; Kanth P; Jiang L; DeBerardinis RJ; Bronner MP; Li DY; Cox JE; Christofk HR; Lowry WE; Thummel CS; Rutter J
[Ad] Endereço:Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
[Ti] Título:Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.
[So] Source:Nat Cell Biol;19(9):1027-1036, 2017 Sep.
[Is] ISSN:1476-4679
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells.
[Mh] Termos MeSH primário: Proliferação Celular
Drosophila melanogaster/metabolismo
Glicólise
Intestinos/metabolismo
Mitocôndrias/metabolismo
Ácido Pirúvico/metabolismo
Células-Tronco/metabolismo
[Mh] Termos MeSH secundário: Acrilatos/farmacologia
Animais
Proteínas de Transporte de Ânions/antagonistas & inibidores
Proteínas de Transporte de Ânions/genética
Proteínas de Transporte de Ânions/metabolismo
Diferenciação Celular
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Proteínas de Drosophila/genética
Proteínas de Drosophila/metabolismo
Drosophila melanogaster/citologia
Genótipo
Seres Humanos
Intestinos/citologia
Intestinos/efeitos dos fármacos
Ácido Láctico/metabolismo
Camundongos Knockout
Mitocôndrias/efeitos dos fármacos
Proteínas de Transporte da Membrana Mitocondrial/antagonistas & inibidores
Proteínas de Transporte da Membrana Mitocondrial/genética
Proteínas de Transporte da Membrana Mitocondrial/metabolismo
Proteínas Mitocondriais/metabolismo
Fenótipo
Interferência de RNA
Receptores Acoplados a Proteínas-G/genética
Receptores Acoplados a Proteínas-G/metabolismo
Transdução de Sinais
Células-Tronco/efeitos dos fármacos
Fatores de Tempo
Técnicas de Cultura de Tecidos
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Anion Transport Proteins); 0 (Drosophila Proteins); 0 (Lgr5 protein, mouse); 0 (MPC1 protein, Drosophila); 0 (MPC1 protein, human); 0 (MPC1 pyruvate carrier protein, mouse); 0 (Mitochondrial Membrane Transport Proteins); 0 (Mitochondrial Proteins); 0 (Receptors, G-Protein-Coupled); 33X04XA5AT (Lactic Acid); 56396-35-1 (2-cyano-3-(1-phenylindol-3-yl)acrylate); 8558G7RUTR (Pyruvic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1038/ncb3593


  5 / 7449 MEDLINE  
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[PMID]:28812580
[Au] Autor:Flores A; Schell J; Krall AS; Jelinek D; Miranda M; Grigorian M; Braas D; White AC; Zhou JL; Graham NA; Graeber T; Seth P; Evseenko D; Coller HA; Rutter J; Christofk HR; Lowry WE
[Ad] Endereço:Department of Molecular Cell and Developmental Biology, UCLA, 90095, USA.
[Ti] Título:Lactate dehydrogenase activity drives hair follicle stem cell activation.
[So] Source:Nat Cell Biol;19(9):1017-1026, 2017 Sep.
[Is] ISSN:1476-4679
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. Furthermore, lactate generation appears to be critical for the activation of HFSCs as deletion of lactate dehydrogenase (Ldha) prevented their activation. Conversely, genetically promoting lactate production in HFSCs through mitochondrial pyruvate carrier 1 (Mpc1) deletion accelerated their activation and the hair cycle. Finally, we identify small molecules that increase lactate production by stimulating Myc levels or inhibiting Mpc1 carrier activity and can topically induce the hair cycle. These data suggest that HFSCs maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli.
[Mh] Termos MeSH primário: Proliferação Celular
Senescência Celular
Glicólise
Folículo Piloso/enzimologia
L-Lactato Desidrogenase/metabolismo
Ácido Láctico/metabolismo
Células-Tronco/enzimologia
[Mh] Termos MeSH secundário: Acrilatos/farmacologia
Animais
Proteínas de Transporte de Ânions/antagonistas & inibidores
Proteínas de Transporte de Ânions/genética
Proteínas de Transporte de Ânions/metabolismo
Proliferação Celular/efeitos dos fármacos
Senescência Celular/efeitos dos fármacos
Feminino
Genótipo
Glicólise/efeitos dos fármacos
Folículo Piloso/citologia
Folículo Piloso/efeitos dos fármacos
Isoenzimas/deficiência
Isoenzimas/genética
Isoenzimas/metabolismo
L-Lactato Desidrogenase/deficiência
L-Lactato Desidrogenase/genética
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Proteínas de Transporte da Membrana Mitocondrial/antagonistas & inibidores
Proteínas de Transporte da Membrana Mitocondrial/genética
Proteínas de Transporte da Membrana Mitocondrial/metabolismo
Fenótipo
Proteínas Proto-Oncogênicas c-myc/metabolismo
Transdução de Sinais
Células-Tronco/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Anion Transport Proteins); 0 (Isoenzymes); 0 (MPC1 pyruvate carrier protein, mouse); 0 (Mitochondrial Membrane Transport Proteins); 0 (Myc protein, mouse); 0 (Proto-Oncogene Proteins c-myc); 33X04XA5AT (Lactic Acid); 56396-35-1 (2-cyano-3-(1-phenylindol-3-yl)acrylate); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 1.1.1.27.- (lactate dehydrogenase 5)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1038/ncb3575


  6 / 7449 MEDLINE  
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[PMID]:28764891
[Au] Autor:Tian X; Qiu YR
[Ad] Endereço:College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
[Ti] Título:2-methoxyethylacrylate modified polysulfone membrane and its blood compatibility.
[So] Source:Arch Biochem Biophys;631:49-57, 2017 Oct 01.
[Is] ISSN:1096-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hydrophilic material 2-methoxyethylacrylate (MEA) was grafted onto polysulfone (PSF) membrane via Michael addition reaction. The H nuclear magnetic resonance ( H NMR), Attenuated total reflectance-Fourier transform infrared spectroscope (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) characterization of the modified membrane proved that MEA had been successfully grafted onto PSF membrane surface. The water contact angle of the membrane surface was tested. The results showed that the water contact angle changed from 76° to 59.5°, which means that the hydrophilicity of the modified membrane was improved. A series of blood compatibility tests including bovine serum protein adsorption, platelet adhesion, prothrombin time (PT), partial thromboplastin time (APTT) and thrombin time (TT) were carried out on PSF membrane and the modified PSF membrane with highest grafted density of MEA. All of the results indicate that MEA plays an important role in improving the blood compatibility of PSF membrane.
[Mh] Termos MeSH primário: Acrilatos/química
Materiais Biocompatíveis/química
Teste de Materiais
Membranas Artificiais
Polímeros/química
Sulfonas/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Coagulação Sanguínea
Plaquetas/citologia
Bovinos
Interações Hidrofóbicas e Hidrofílicas
Espectroscopia Fotoeletrônica
Adesividade Plaquetária
Soroalbumina Bovina/isolamento & purificação
Espectroscopia de Infravermelho com Transformada de Fourier
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Biocompatible Materials); 0 (Membranes, Artificial); 0 (Polymers); 0 (Sulfones); 0 (poly(2-methoxyethylacrylate)); 25135-51-7 (polysulfone P 1700); 27432CM55Q (Serum Albumin, Bovine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28686044
[Au] Autor:Bakkiyaraj D; Sritharadol R; Padmavathi AR; Nakpheng T; Srichana T
[Ad] Endereço:a Nanotec-PSU Excellence Center on Drug Delivery System, Faculty of Pharmaceutical Sciences , Prince of Songkla University , Hat Yai , Thailand.
[Ti] Título:Anti-biofilm properties of a mupirocin spray formulation against Escherichia coli wound infections.
[So] Source:Biofouling;33(7):591-600, 2017 Aug.
[Is] ISSN:1029-2454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mupirocin ointment is a widely used topical drug for the treatment of bacterial skin infections. However, ointments have some limitations which motivated the development of a film forming spray of mupirocin. Mupirocin spray (2%) was formulated with Eudragit E100 as a film forming agent and tested for its antibacterial and anti-biofilm activities against Escherichia coli, a skin pathogen causing wound and surgical site infections. Treatment with mupirocin spray resulted in significant antibacterial and anti-biofilm activities (inhibition and disruption) with single spray and sub-actual dose concentrations at par with the commercial ointment concentration. The spray formulation was found to be non-toxic to fibroblast cells and greatly resisted removal from the site of application upon washing, in contrast to the ointment which was significantly removed after a single wash. This is the first study to develop and evaluate a spray formulation for mupirocin that forms a stable thin film for sustained release of the drug.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Biofilmes/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Mupirocina/farmacologia
Dermatopatias Bacterianas/tratamento farmacológico
Infecções Estafilocócicas/tratamento farmacológico
Infecção dos Ferimentos/tratamento farmacológico
[Mh] Termos MeSH secundário: Acrilatos/química
Administração Cutânea
Aerossóis
Antibacterianos/administração & dosagem
Antibacterianos/toxicidade
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Composição de Medicamentos
Escherichia coli/isolamento & purificação
Seres Humanos
Mupirocina/administração & dosagem
Mupirocina/toxicidade
Pomadas
Polímeros/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Aerosols); 0 (Anti-Bacterial Agents); 0 (Eudragit E100); 0 (Ointments); 0 (Polymers); D0GX863OA5 (Mupirocin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1080/08927014.2017.1337100


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[PMID]:28685563
[Au] Autor:Romita P; Foti C; Masciopinto L; Nettis E; Di Leo E; Calogiuri G; Bonamonte D; Angelini G; Dipalma G; Ballini A; Inchingolo F
[Ad] Endereço:Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari "Aldo Moro", Bari, Italy.
[Ti] Título:Allergic contact dermatitis to acrylates.
[So] Source:J Biol Regul Homeost Agents;31(2):529-534, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Acrylates and methacrylates are a large group of chemically reactive monomers that are polymerized into acrylic plastics. These have very broad applications in glues, coatings and various plastic materials. Allergic contact dermatitis (ACD) caused by acrylates can be occupational, mainly in dentistry workers during the manufacturing and implantation of dental prosthesis, and in nail technicians during the sculpturing and application of artificial nails. The clinical manifestations vary according to the location of the contact. In non-occupational ACD, hand eczema, pulpitis and stomatitis are more frequent. We conducted a study to investigate the frequency of sensitization to acrylates, determining the most frequently sensitizing acrylates and assessing the possible role of 2-hydroxyethyl methacrylate (2-HEMA) as a screening allergen. From January 2013 to December 2014, 217 patients with a personal history and symptoms suggestive of contact dermatitis were patch tested with an extended series of acrylates at the Dermatology and Allergology Units of the University Hospital of Bari. Seven patients (3.2%) had positive reactions. The reactions were related to artificial nails in 2 patients (28.6%), both beauticians, and dental material in 5 patients (71.4%) with dental prosthesis. 2-HEMA detected 100%of sensitized patients to acrylates.
[Mh] Termos MeSH primário: Acrilatos/toxicidade
Prótese Dentária
Dermatite Alérgica de Contato/diagnóstico
Dermatite Alérgica de Contato/epidemiologia
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  9 / 7449 MEDLINE  
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[PMID]:28669445
[Au] Autor:McConkey GA; Bedingfield PTP; Burrell DR; Chambers NC; Cunningham F; Prior TJ; Fishwick CWG; Boa AN
[Ad] Endereço:School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
[Ti] Título:Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.
[So] Source:Bioorg Med Chem Lett;27(16):3878-3882, 2017 08 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new tricyclic ß-aminoacrylate derivatives (2e and 3e) have been found to be inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with Ki 0.037 and 0.15µM respectively. H and C NMR spectroscopic data show that these compounds undergo ready cis-trans isomerisation at room temperature in polar solvents. In silico docking studies indicate that for both molecules there is neither conformation nor double bond configuration which bind preferentially to PfDHODH. This flexibility is favourable for inhibitors of this channel that require extensive positioning to reach their binding site.
[Mh] Termos MeSH primário: Acrilatos/farmacologia
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/antagonistas & inibidores
Plasmodium falciparum/enzimologia
[Mh] Termos MeSH secundário: Acrilatos/síntese química
Acrilatos/química
Relação Dose-Resposta a Droga
Simulação de Acoplamento Molecular
Estrutura Molecular
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/genética
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acrylates); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.5.2 (dihydroorotate dehydrogenase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


  10 / 7449 MEDLINE  
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[PMID]:28661687
[Au] Autor:Patil VS; Gutierrez AM; Sunkara M; Morris AJ; Hilt JZ; Kalika DS; Dziubla TD
[Ad] Endereço:Department of Chemical and Materials Engineering, University of Kentucky , Lexington, Kentucky 40506, United States.
[Ti] Título:Curcumin Acrylation for Biological and Environmental Applications.
[So] Source:J Nat Prod;80(7):1964-1971, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Curcumin has recently gained interest for use in drug delivery, chemical sensing, and environmental applications. As a result, the development of synthesis strategies for the incorporation of curcumin into novel materials has become a priority. One such strategy, curcumin acrylation, involves the introduction of acrylate functional groups to the curcumin scaffold, with the potential generation of mono-, di-, and triacrylate curcumin species. The relative populations of these species in the resulting multiacrylate mixture can be controlled by the ratio of curcumin to acryloyl chloride in the initial reaction formulation. Characterization of the acrylation reaction and the resulting curcumin multiacrylate product is essential for the effective preparation of new curcumin-containing materials. In this work, a synthesis method for curcumin acrylation is presented and the resulting curcumin multiacrylate product is characterized via various techniques, i.e., HPLC, LCMS, and NMR, as a basis to establish the relationship between synthesis conditions and the extent of acrylation that is achieved.
[Mh] Termos MeSH primário: Curcumina/química
[Mh] Termos MeSH secundário: Acrilatos/metabolismo
Cromatografia Líquida de Alta Pressão
Curcumina/metabolismo
Sistemas de Liberação de Medicamentos/métodos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 8K23O56TG5 (acryloyl chloride); IT942ZTH98 (Curcumin); J94PBK7X8S (acrylic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00951



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