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[PMID]:29254452
[Au] Autor:García-Alva R; Guerrero-Hernández M; Anaya-Ayala JE; Leal-Anaya P; Gabutti A; Picazo A; Hinojosa CA
[Ad] Endereço:1 Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.
[Ti] Título:Successful Embolization of a Ruptured Ovarian Artery Aneurysm in a Postmenopausal Woman: Case Report and Literature Review of Gonadal Artery Aneurysms.
[So] Source:Vasc Endovascular Surg;52(2):159-163, 2018 Feb.
[Is] ISSN:1938-9116
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gonadal artery aneurysms (GADs) are extremely rare; their prevalence and natural history are unknown and their pathogenesis remains poorly understood. Based on the limited literature reports, these might present with rupture (ovarian artery) or pain and acute thrombosis (testicular artery). The present article reports the case of an 80-year-old woman who came to the emergency department (ED) with acute onset of abdominal and left flank pain. A computed tomography angiography (CTA) revealed a large retroperitoneal hematoma associated with the presence of a left ovarian artery aneurysm. The patient was taken to the angiography suite for a selective vessel catheterization and embolization with N-butyl-2-cyanoacrylate (NBCA). Following the procedure, her serial hemoglobin remained stable, her symptoms subsided, and she was discharged home 2 days later. The GADs are unrecognized entities until an acute event such as rupture occurs, and vessel embolization is effective for hemorrhage control. Close communication and collaboration with gynecologists and urologists are crucial to better define the prevalence, natural history, and the appropriate behavior and timing for elective treatment. With this article, the authors additionally present a review of the literature.
[Mh] Termos MeSH primário: Aneurisma Roto/terapia
Artérias
Embolização Terapêutica
Embucrilato/administração & dosagem
Ovário/irrigação sanguínea
Pós-Menopausa
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Aneurisma Roto/diagnóstico por imagem
Artérias/diagnóstico por imagem
Angiografia por Tomografia Computadorizada
Feminino
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1177/1538574417747427


  2 / 1502 MEDLINE  
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[PMID]:28462783
[Au] Autor:Lee H; Yoon CJ; Seong NJ; Jeon CH; Yoon HI; Go J
[Ad] Endereço:Division of Vascular and Interventional Radiology, Department of Radiology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea, 13620.
[Ti] Título:Cryptogenic Hemoptysis: Effectiveness of Bronchial Artery Embolization Using N-Butyl Cyanoacrylate.
[So] Source:J Vasc Interv Radiol;28(8):1161-1166, 2017 Aug.
[Is] ISSN:1535-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe angiographic findings and assess safety and effectiveness of bronchial artery embolization (BAE) with N-butyl cyanoacrylate (NBCA) in patients with cryptogenic hemoptysis (CH). MATERIALS AND METHODS: Between May 2003 and March 2014, 26 patients who underwent BAE for CH were enrolled. A retrospective review was conducted for angiographic findings and clinical outcomes of BAE, including technical and clinical success, complications, and recurrent hemoptysis. RESULTS: Selective arteriograms were abnormal in 22 patients (85%), showing hypertrophied bronchial arteries (n = 19), parenchymal hypervascularity (n = 18), and bronchial-to-pulmonary shunting (n = 8). All abnormal bronchial and nonbronchial collateral arteries (n = 36) were successfully embolized with NBCA. Hemoptysis ceased within 24 hours in all patients. There were no procedure-related complications. During 11-117 months of follow-up (median, 60.2 mo), 1 patient (4%) experienced recurrent hemoptysis at 5 months after initial BAE, which was treated with repeat BAE. The 5-year hemoptysis-free survival rate was 96%. CONCLUSIONS: Bronchial arteries were angiographically abnormal in most patients with CH (85%). BAE is a safe and effective treatment with excellent short- and long-term results in patients with CH. NBCA appears to be a useful embolic material for this application.
[Mh] Termos MeSH primário: Artérias Brônquicas
Embolização Terapêutica/métodos
Embucrilato/uso terapêutico
Hemoptise/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Angiografia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Taxa de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 1502 MEDLINE  
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[PMID]:28502685
[Au] Autor:Shakur SF; Brunozzi D; Setabutr P; Hussein AE; Charbel FT; Alaraj A
[Ad] Endereço:Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois.
[Ti] Título:Transorbital Glue Embolization of a Recurrent Venous Varix Using Real-Time Image Guidance in the Neuroangiography Suite.
[So] Source:World Neurosurg;104:1045.e1, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orbital lesions are challenging to access due to their location amid critical anatomic structures. Here, we demonstrate direct transorbital cannulation of an orbital venous varix using image guidance. A 36-year-old male was diagnosed with a left orbital venous varix approximately 5 years ago at an outside institution. He subsequently underwent surgery for direct intraoperative embolization of the venous varix followed by surgical resection. The patient recently presented to us with left eye pain, proptosis, double vision, and conjunctival hemorrhage precipitated by straining or lying flat. Orbital magnetic resonance imaging showed recurrence of the venous varix, which was then confirmed with digital subtraction angiography and intraprocedural computed tomography (DynaCT, Siemens Healthineers, Erlangen, Germany). Due to scarring from the previous surgery, percutaneous transorbital embolization of the venous varix was planned. The needle trajectory was determined and also visualized in real-time using image guidance (Needle Guidance, Siemens Healthineers). Once the needle reached the desired target, n-butyl cyanoacrylate glue (Codman Neuro, San Jose, California) was injected until nearly the entire venous varix was occluded. There were no complications, and at his postoperative visit the patient reported resolution of all symptoms.
[Mh] Termos MeSH primário: Adesivos/uso terapêutico
Embolização Terapêutica/métodos
Embucrilato/uso terapêutico
Órbita/irrigação sanguínea
Varizes/terapia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Adhesives); F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


  4 / 1502 MEDLINE  
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[PMID]:28481657
[Au] Autor:Jin X; Asghar S; Zhu X; Chen Z; Liu J; Li Y; Li H; Ping Q; Xiao Y
[Ad] Endereço:a Department of Pharmaceutics, State Key Laboratory of Natural Medicines , China Pharmaceutical University , Nanjing , PR China.
[Ti] Título:Enhanced oral bioavailability of 10-hydroxycamptothecin through the use of poly (n-butyl cyanoacrylate) nanospheres.
[So] Source:Drug Dev Ind Pharm;43(10):1637-1647, 2017 Oct.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The article describes the preparation, physicochemical characterization, drug release, and in vivo behavior of 10-hydroxycamptothecin-loaded poly (n-butyl cyanoacrylate) (PBCA) nanospheres (HCPT-PBCA-NSs). HCPT-PBCA-NSs were successfully prepared via emulsion polymerization of n-butyl cyanoacrylate (BCA) monomer in acidic medium with the aid of two colloidal stabilizers (Poloxamer 188 and Dextran 70). The influence of pH, the time of polymerization, and the dosage of the drug on particle size and encapsulation efficiency (EE) were studied. HCPT-PBCA-NSs were of spherical shape and uniformly dispersed with a particle size of 135.7 nm, and zeta potential of -18.18 mV. EE, drug loading (DL), and yield of HCPT-PBCA-NSs were 51.52, 0.63, and 88.25%, respectively. FTIR, H NMR, and DSC showed complete polymerization of BCA monomer and HCPT existed in the form of molecular or amorphous in NSs. In vitro release of the drug from HCPT-PBCA-NSs exhibited sustained-release behavior with an initial burst release and about 60% of HCPT was released from the formulation within 24 h of dialysis. The pharmacokinetic study in healthy rats after oral administration showed that encapsulation of HCPT into PBCA-NSs increased the C about 3.84 times and increased AUC about 5.40 times compared with that of HCPT suspension. It was concluded that PBCA-NSs could be a promising drug carrier to load HCPT for oral drug delivery if efforts are made in the future to improve its poor DL capacity.
[Mh] Termos MeSH primário: Camptotecina/análogos & derivados
Sistemas de Liberação de Medicamentos/métodos
Embucrilato/química
Nanopartículas/química
Nanosferas/química
Poloxâmero/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Camptotecina/administração & dosagem
Camptotecina/química
Química Farmacêutica
Portadores de Fármacos
Emulsões
Embucrilato/administração & dosagem
Tamanho da Partícula
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Emulsions); 106392-12-5 (Poloxamer); 9Z01632KRV (10-hydroxycamptothecin); F8CEP82QNP (Enbucrilate); XT3Z54Z28A (Camptothecin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1328432


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[PMID]:28445368
[Au] Autor:Yontar Y; Özyazgan I
[Ad] Endereço:Kayseri, Turkey From the Kayseri Training and Research Hospital, Clinic of Plastic, Reconstructive, and Aesthetic Surgery; and the Department of Plastic, Reconstructive, and Aesthetic Surgery, Erciyes University, Medical Faculty.
[Ti] Título:Correcting Concavity of Rabbit Auricular Cartilage: Comparison of Single Scoring Incisions with Butyl Cyanoacrylate-Aided Techniques.
[So] Source:Plast Reconstr Surg;139(5):1152-1164, 2017 May.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The authors present the results of an experimental study in which four different techniques were used for the correction of concave rabbit auricular cartilage. METHODS: Sixteen New Zealand adult male rabbits were used in the study. Butyl cyanoacrylate-aided cartilage graft fixation and butyl cyanoacrylate-aided bone graft fixation and scoring technique, alone or combined with butyl cyanoacrylate application, were performed to correct the concavity of rabbit auricular cartilage. RESULTS: Angle measurements showed that all four techniques were efficient for correction of the cartilage concavities. However, the mean postsacrifice angles of the graft fixation groups were significantly higher than those of the other study groups, reflecting the fact that graft fixation with butyl cyanoacrylate application was more efficient for preserving the final cartilage shape. Furthermore, in the ninth month, graft fixation groups had the lowest chondrocyte densities, the highest degree of inflammation, the highest degree of foreign body reaction, and the highest butyl cyanoacrylate density. CONCLUSIONS: Fibrosis or chondrocyte proliferation on scoring incision lines is not an associated feature of this technique. When the incision depths were standardized, the scoring technique provided efficacy similar to that of the scoring incisions combined with butyl cyanoacrylate application for correction of the cartilage concavity. The scoring incision plus butyl cyanoacrylate group showed less toxicity than the graft fixation groups because of rapid removal of toxic breakdown products. Graft fixation techniques were superior to other corrective procedures with regard to preservation of the final cartilage shape. Although they resulted in greater toxicity, the cartilage correction was not affected unfavorably.
[Mh] Termos MeSH primário: Cartilagem da Orelha/cirurgia
Embucrilato/uso terapêutico
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Animais
Embucrilato/toxicidade
Masculino
Complicações Pós-Operatórias/etiologia
Coelhos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003273


  6 / 1502 MEDLINE  
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[PMID]:28335495
[Au] Autor:Chung CY; Lin MH; Lee IN; Lee TH; Lee MH; Yang JT
[Ad] Endereço:Department of Neurosurgery, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan. yen5103106@gmail.com.
[Ti] Título:Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells.
[So] Source:Int J Mol Sci;18(3), 2017 Mar 19.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Brain derived neurotrophic factor (BDNF) can induce neural differentiation in stem cells and has the potential for repair of the nervous system. In this study, a polysorbate 80-coated polybutylcyanoacrylate nanocarrier (PS80 PBCA NC) was constructed to deliver plasmid DNAs ( DNAs) containing BDNF gene attached to a hypoxia-responsive element (HRE-cmvBDNF). The hypoxia-sensing mechanism of BDNF expression and inductiveness of the nano-formulation on mouse induced pluripotent stem cells (iPSCs) to differentiate into neurons following hypoxia was tested in vitro with immunofluorescent staining and Western blotting. The HRE-cmvBDNF appeared to adsorb onto the surface of PS80 PBCA NC, with a resultant mean diameter of 92.6 ± 1.0 nm and zeta potential of -14.1 ± 1.1 mV. HIF-1α level in iPSCs was significantly higher in hypoxia, which resulted in a 51% greater BDNF expression when transfected with PS80 PBCA NC/HRE-cmvBDNF than those without hypoxia. TrkB and phospho-Akt were also elevated which correlated with neural differentiation. The findings suggest that PS80 PBCA NC too can be endocytosed to serve as an efficient vector for genes coupled to the HRE in hypoxia-sensitive cells, and activation of the PI3/Akt pathway in iPSCs by BDNF is capable of neural lineage specification.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/genética
Diferenciação Celular
Embucrilato/química
Células-Tronco Pluripotentes Induzidas/citologia
Nanopartículas/química
Neurônios/citologia
[Mh] Termos MeSH secundário: Animais
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Hipóxia Celular
Linhagem Celular
Embucrilato/efeitos adversos
Vetores Genéticos/administração & dosagem
Subunidade alfa do Fator 1 Induzível por Hipóxia/genética
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
Células-Tronco Pluripotentes Induzidas/metabolismo
Camundongos
Neurônios/metabolismo
Fosfatidilinositol 3-Quinases/metabolismo
Polissorbatos/química
Proteínas Proto-Oncogênicas c-akt/metabolismo
RNA/administração & dosagem
Elementos de Resposta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (Polysorbates); 0 (RNA, recombinant); 63231-63-0 (RNA); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  7 / 1502 MEDLINE  
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[PMID]:28273742
[Au] Autor:Jang HY; Kim KW; Kwon JH; Kwon HJ; Kim B; Seo N; Lee J; Song GW; Lee SG
[Ad] Endereço:1 Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
[Ti] Título:N-butyl-2 cyanoacrylate (NBCA) embolus in the graft portal vein after portosystemic collateral embolization in liver transplantation recipient: what is the clinical significance?
[So] Source:Acta Radiol;58(11):1326-1333, 2017 Nov.
[Is] ISSN:1600-0455
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background An N-butyl-2 cyanoacrylate (NBCA) embolus in the graft portal vein was frequently observed after an intraoperative embolization of portosystemic collaterals performed to prevent portal steal in liver transplant (LT) recipients. The radiological and clinical features of NBCA emboli have not yet been described. Purpose To describe radiological and clinical features of NBCA embolus in graft portal vein after portosystemic collateral embolization in LT recipients. Material and Methods A total of 165 consecutive LT recipients who had undergone intraoperative NBCA embolization of varix were found in single institution's computerized databases of a clinical cohort of LT. Patients were evaluated for NBCA emboli (categorized into major and minor emboli according to location) on first postoperative computed tomography (CT). All electronic medical records and radiologic studies including follow-up was evaluated to determine any radiological and clinical abnormality associated with NBCA embolus. Results NBCA emboli were found in 24% (39/165) of recipients. Although most patients had minor emboli (77%, 30/39) without remarkable ultrasonography (US) abnormalities, seven (78%) of nine recipients with major emboli showed intraluminal echogenic lesions in graft portal vein on grayscale US, and five of them (71%) showed partial portal flow obstruction, although none exhibited any abnormality on contrast-enhanced US. Recipients with NBCA portal emboli showed no significant clinical abnormalities and were discharged safely. NBCA embolus eventually disappeared mostly within six months (82%, 32/39). Conclusion NBCA emboli are frequently observed after portosystemic collateral embolization in LT recipients and are not associated with poor clinical outcome. They may mimic ordinary thromboemboli on US.
[Mh] Termos MeSH primário: Embolia/diagnóstico por imagem
Embolização Terapêutica
Embucrilato
Transplante de Fígado
Veia Porta/diagnóstico por imagem
Complicações Pós-Operatórias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Tomografia Computadorizada por Raios X
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1177/0284185117693460


  8 / 1502 MEDLINE  
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[PMID]:28272716
[Au] Autor:Shen YM; Liu YT; Chen J; Sun L
[Ad] Endereço:Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. chenjie20160628@163.com.
[Ti] Título:Efficacy and safety of NBCA (n-butyl-2-cyanoacrylate) medical adhesive for patch fixation in totally extraperitoneal prosthesis (TEP): a prospective, randomized, controlled trial.
[So] Source:Eur Rev Med Pharmacol Sci;21(4):680-686, 2017 Feb.
[Is] ISSN:2284-0729
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the effectiveness of n-butyl-2-cyanoacrylate (NBCA) medical adhesive for mesh fixation in totally extraperitoneal prosthesis (TEP) for inguinal hernia repair. PATIENTS AND METHODS: A total of 160 patients with primary unilateral inguinal hernia were assigned randomly to receive TEP using NBCA medical adhesive for patch fixation (experimental group) and without patch fixation (control group). We evaluated operation time, visual analogue scale (VAS) pain score 24 h after surgery, postoperative duration of stay, hospital costs, postoperative complications, and hernia recurrence. RESULTS: A total of 160 cases were operated successfully. There was no significant difference in operation time, VAS pain score 24h after surgery, postoperative duration of stay, hospital costs and postoperative complications between the groups (p > 0.05). Hernia recurrence occurred in 4 cases of the control group. None of the experimental group had a significant difference (p < 0.05). CONCLUSIONS: The use of NBCA medical adhesive for patch fixation in TEP is effective and safe.
[Mh] Termos MeSH primário: Embucrilato/uso terapêutico
Hérnia Inguinal/cirurgia
Próteses e Implantes
Adesivos Teciduais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Laparoscopia
Masculino
Meia-Idade
Dor Pós-Operatória/tratamento farmacológico
Complicações Pós-Operatórias/cirurgia
Estudos Prospectivos
Recidiva
Telas Cirúrgicas
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Tissue Adhesives); F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


  9 / 1502 MEDLINE  
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[PMID]:28256302
[Au] Autor:Kim PH; Tsauo J; Shin JH; Yun SC
[Ad] Endereço:Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 86, Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Republic of Korea.
[Ti] Título:Transcatheter Arterial Embolization of Gastrointestinal Bleeding with N-Butyl Cyanoacrylate: A Systematic Review and Meta-Analysis of Safety and Efficacy.
[So] Source:J Vasc Interv Radiol;28(4):522-531.e5, 2017 Apr.
[Is] ISSN:1535-7732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the safety and efficacy of transcatheter arterial embolization with N-butyl cyanoacrylate (NBCA) for the treatment of gastrointestinal (GI) bleeding via a meta-analysis of published studies. MATERIALS AND METHODS: The MEDLINE/PubMed and EMBASE databases were searched for English-language studies from January 1990 to March 2016 that included patients with nonvariceal GI bleeding treated with transcatheter arterial embolization with NBCA with or without other embolic agents. The exclusion criteria were a sample size of < 5, no extractable data, or data included in subsequent articles or duplicate reports. RESULTS: The cases of 440 patients (mean age, 63.8 y ± 14.3; 319 men [72.5%] and 121 women [27.5%]) from 15 studies were evaluated. Of these patients, 261 (59.3%) had upper GI bleeding (UGIB) and 179 (40.7%) had lower GI bleeding (LGIB). Technical success was achieved in 99.2% of patients with UGIB (259 of 261) and 97.8% of those with LGIB (175 of 179). The pooled clinical success and major complication rates in the 259 patients with UGIB in whom technical success was achieved were 82.1% (95% confidence interval [CI], 73.0%-88.6%; P = 0.058; I = 42.7%) and 5.4% (95% CI, 2.8%-10.0%; P = 0.427; I = 0.0%), respectively, and those in the 175 patients with LGIB in whom technical success was achieved were 86.1% (95% CI, 79.9%-90.6%; P = 0.454; I = 0.0%) and 6.1% (95% CI, 3.1%-11.6%; P = 0.382; I = 4.4%), respectively. CONCLUSIONS: Transcatheter arterial embolization with NBCA is safe and effective for the treatment of GI bleeding.
[Mh] Termos MeSH primário: Embolização Terapêutica/métodos
Embucrilato/administração & dosagem
Hemorragia Gastrointestinal/terapia
[Mh] Termos MeSH secundário: Idoso
Embolização Terapêutica/efeitos adversos
Embolização Terapêutica/mortalidade
Embucrilato/efeitos adversos
Feminino
Hemorragia Gastrointestinal/diagnóstico
Hemorragia Gastrointestinal/mortalidade
Seres Humanos
Masculino
Meia-Idade
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28251148
[Au] Autor:Obata S; Kasai M; Kasai J; Seki K; Sekikawa Z; Torimoto I; Takebayashi S; Hirahara F; Aoki S
[Ad] Endereço:Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.
[Ti] Título:Emergent Uterine Arterial Embolization Using N-Butyl Cyanoacrylate in Postpartum Hemorrhage with Disseminated Intravascular Coagulation.
[So] Source:Biomed Res Int;2017:1562432, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although it is widely accepted that uterine artery embolization (UAE) is an effective therapeutic strategy for postpartum hemorrhage (PPH), no consensus has been reached regarding the efficacy of UAE in patients with PPH with disseminated intravascular coagulation (DIC). This single-center retrospective cohort study included patients treated with UAE using NBCA for PPH between 2010 and 2015. The patients were divided into DIC and non-DIC groups, according to the obstetrical DIC score and the overt DIC diagnostic criteria issued by the International Society of Thrombosis and Haemostasis (ISTH), and their clinical outcomes were compared. There were 28 patients treated with UAE using NBCA. Complete hemostasis was achieved by UAE in 19 of 28 patients. In eight of nine patients with unsuccessful hemostasis, surgical hemostatic interventions were performed after UAE, and hemostasis was achieved in seven patients. UAE using NBCA showed no significant intergroup differences in complete hemostasis according to the presence or absence of DIC based on obstetrical DIC score (70% versus 62.5%, = 1.000) or ISTH DIC score (54.5% versus 76.5%, = 0.409). UAE using NBCA may be a useful first-choice treatment for PPH with DIC.
[Mh] Termos MeSH primário: Coagulação Intravascular Disseminada/complicações
Coagulação Intravascular Disseminada/terapia
Embucrilato/farmacologia
Hemorragia Pós-Parto/terapia
Embolização da Artéria Uterina/métodos
Artéria Uterina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Feminino
Seres Humanos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
F8CEP82QNP (Enbucrilate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1155/2017/1562432



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