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Pesquisa : D02.241.081.193 [Categoria DeCS]
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[PMID]:28610437
[Au] Autor:Song Y; Zhou J; Wang X; Xie X; Zhao Y; Ni F; Huang W; Wang Z; Xiao W
[Ad] Endereço:a Jiangsu Kanion Pharmaceutical Co., Ltd. , Lianyungang , People's Republic of China.
[Ti] Título:A new ferulic acid ester from Rhodiola wallichiana var. cholaensis (Crassulaceae).
[So] Source:Nat Prod Res;32(1):77-84, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound 3 was isolated from this plant for the first time. The protective effects against H O -induced myocardial cell injury in cultured H9c2 cells were also evaluated. Compounds 1, 5 and 7-11 provided significant protective effects on H O -induced H9c2 cells injury at the concentration of 25 µg/mL. And the protective effects of compound 1 was also investigated by the oxygen-glucose deprivation/reperfusion (OGD/R) tests.
[Mh] Termos MeSH primário: Caproatos/farmacologia
Cardiotônicos/farmacologia
Ácidos Cumáricos/farmacologia
Rhodiola/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/farmacologia
Caproatos/administração & dosagem
Caproatos/química
Cardiotônicos/administração & dosagem
Cardiotônicos/química
Células Cultivadas
Ácidos Cumáricos/administração & dosagem
Ácidos Cumáricos/química
Relação Dose-Resposta a Droga
Ésteres/administração & dosagem
Ésteres/química
Ésteres/farmacologia
Peróxido de Hidrogênio/toxicidade
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Miócitos Cardíacos/citologia
Miócitos Cardíacos/efeitos dos fármacos
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Caproates); 0 (Cardiotonic Agents); 0 (Coumaric Acids); 0 (Esters); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335724


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[PMID]:29447012
[Au] Autor:Gao X; Tang J; Liu H; Liu L; Kang L; Chen W
[Ad] Endereço:a Key Laboratory Breeding Base of Hu'nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy , Changsha Medical University , Changsha , China.
[Ti] Título:Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid.
[So] Source:J Enzyme Inhib Med Chem;33(1):519-524, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d-6g, 10d-12g, 16d-18g and 22d-24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of aminoalkyl types and substituted positions markedly influences the effects in inhibiting AChE. Almost of all cinnamic acid derivatives had the most potent inhibitory activity than that of other acid derivatives with the same aminoalkyl side chain. Unsaturated bond and benzene ring in cinnamic acid scaffold seems important for the inhibitory activity against AChE. Among them, compound 6g revealed the most potent AChE inhibitory activity (IC value: 3.64 µmol/L) and highest selectivity over BChE (ratio: 28.6). Enzyme kinetic study showed that it present a mixed-type inhibition against AChE. The molecular docking study suggested that it can bind with the catalytic site and peripheral site of AChE.
[Mh] Termos MeSH primário: Aminas/farmacologia
Caproatos/farmacologia
Inibidores da Colinesterase/farmacologia
Cinamatos/farmacologia
Fenilpropionatos/farmacologia
Ácido Sórbico/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Aminas/síntese química
Aminas/química
Animais
Butirilcolinesterase/metabolismo
Caproatos/química
Inibidores da Colinesterase/síntese química
Inibidores da Colinesterase/química
Cinamatos/química
Relação Dose-Resposta a Droga
Simulação de Acoplamento Molecular
Estrutura Molecular
Fenilpropionatos/química
Ratos
Ratos Sprague-Dawley
Ácido Sórbico/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Caproates); 0 (Cholinesterase Inhibitors); 0 (Cinnamates); 0 (Phenylpropionates); 1F8SN134MX (hexanoic acid); 5Q445IN5CU (3-phenylpropionic acid); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); U14A832J8D (cinnamic acid); X045WJ989B (Sorbic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1436053


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[PMID]:29364609
[Ti] Título:[Not Available.]
[So] Source:Mikrobiologiia;85(5):613-616, 2016 Sep.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Actinobacteria/metabolismo
Caprolactama/análogos & derivados
Caprolactama/metabolismo
Polímeros/metabolismo
[Mh] Termos MeSH secundário: Acetilcoenzima A/metabolismo
Actinobacteria/isolamento & purificação
Adipatos/metabolismo
Ácido Aminocaproico/metabolismo
Caproatos/metabolismo
Meios de Cultura/química
Hidrólise
Esgotos/microbiologia
Ácido Succínico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (6-oxohexanoic acid); 0 (Adipates); 0 (Caproates); 0 (Culture Media); 0 (Polymers); 0 (Sewage); 25038-54-4 (nylon 6); 6879X594Z8 (Caprolactam); 72-89-9 (Acetyl Coenzyme A); 76A0JE0FKJ (adipic acid); AB6MNQ6J6L (Succinic Acid); U6F3787206 (Aminocaproic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:29248446
[Au] Autor:Sanchez Garcia D; Sjödin M; Hellstrandh M; Norinder U; Nikiforova V; Lindberg J; Wincent E; Bergman Å; Cotgreave I; Munic Kos V
[Ad] Endereço:Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Forskargatan 20, SE-151 36 Södertälje, Sweden.
[Ti] Título:Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs.
[So] Source:Chem Biol Interact;281:1-10, 2018 Feb 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Many chemicals accumulate in organisms through a variety of different mechanisms. Cationic amphiphilic drugs (CADs) accumulate in lysosomes and bind to membranes causing phospholipidosis, whereas many lipophilic chemicals target adipose tissue. Perfluoroalkyl substances (PFASs) are widely used as surfactants, but many of them are highly bioaccumulating and persistent in the environment, making them notorious environmental toxicants. Understanding the mechanisms of their bioaccumulation is, therefore, important for their regulation and substitution with new, less harmful chemicals. We compared the highly bioaccumulative perfluorooctanesulfonic acid PFOS to its three less bioaccumulative alternatives perfluorooctanoic acid (PFOA), perfluorohexanoic acid (PFHxA) and perfluorobutane sulfonic acid (PFBS), in their ability to accumulate and remain in lung epithelial cells (NCI-H292) and adipocytes (3T3-L1K) in vitro. As a reference point we tested a set of cationic amphiphilic drugs (CADs), known to highly accumulate in cells and strongly bind to phospholipids, together with their respective non-CAD controls. Finally, all compounds were examined for their ability to bind to neutral lipids and phospholipids in cell-free systems. Cellular accumulation and retention of the test compounds were highly correlated between the lung epithelial cells and adipocytes. Interestingly, although an anion itself, intensities of PFOS accumulation and retention in cells were comparable to those of CAD compounds, but PFOS failed to induce phospholipidosis or alter lysosomal volume. Compared to other lipophilicity measures, phospholipophilicity shows the highest correlation (Rˆ2 = 0.75) to cellular accumulation data in both cell types and best distinguishes between high and low accumulating compounds. This indicates that binding to phospholipids may be the most important component in driving high cellular accumulation in lung epithelial cells, as well as in adipocytes, and for both CADs and bioaccumulating PFASs. Obtained continuous PLS models based on compound's affinity for phospholipids and neutral lipids can be used as good prediction models of cellular accumulation and retention of PFASs and CADs.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/metabolismo
Fluorcarbonetos/metabolismo
Lisossomos/metabolismo
Preparações Farmacêuticas/metabolismo
Fosfolipídeos/metabolismo
[Mh] Termos MeSH secundário: Adipócitos/citologia
Adipócitos/metabolismo
Ácidos Alcanossulfônicos/química
Animais
Azitromicina/química
Azitromicina/metabolismo
Caproatos/química
Caproatos/metabolismo
Caprilatos/química
Caprilatos/metabolismo
Cátions/química
Linhagem Celular
Sobrevivência Celular
Células Epiteliais/citologia
Células Epiteliais/metabolismo
Fluorcarbonetos/química
Seres Humanos
Análise dos Mínimos Quadrados
Modelos Lineares
Lipídeos/química
Camundongos
Preparações Farmacêuticas/química
Fosfolipídeos/química
Ácidos Sulfônicos/química
Ácidos Sulfônicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Caproates); 0 (Caprylates); 0 (Cations); 0 (Fluorocarbons); 0 (Lipids); 0 (Pharmaceutical Preparations); 0 (Phospholipids); 0 (Sulfonic Acids); 0 (perfluorobutanesulfonic acid); 83905-01-5 (Azithromycin); 947VD76D3L (perfluorooctanoic acid); 9H2MAI21CL (perfluorooctane sulfonic acid); ZP34Q2220R (perfluorohexanoic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171218
[St] Status:MEDLINE


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[PMID]:29172749
[Au] Autor:Li Y; Baiyang L; Leran B; Zhen W; Yandong X; Baixiang D; Dandan Z; Yufu Z; Jun L; Rutong Y; Hongmei L
[Ad] Endereço:a Insititute of Nervous System Diseases , Xuzhou Medical University , Xuzhou , PR China.
[Ti] Título:Reduction-responsive PEtOz-SS-PCL micelle with tailored size to overcome blood-brain barrier and enhance doxorubicin antiglioma effect.
[So] Source:Drug Deliv;24(1):1782-1790, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which were developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) and the micelle size could be regulated by designing the polymer structure. The DOX-loaded PEtOz-SS-PCL micelles had small size and rapid drug release in reductive intracellular environments. Biodistribution and in vivo imaging studies in C6 glioma mice tumor model showed that DOX loaded PEtOz-SS-PCL43 micelles with the smallest size had superior accumulation and fast drug release in tumor sites. In vivo antitumor activity demonstrated that DOX-loaded PEtOz-SS-PCL43 micelles improved antitumor efficacy in contrast to PEtOz-SS-PCL micelles with larger size toward the orthotopic C6-Luci cells-bearing mice. This study shows great potential in tailoring the micelle size and introducing the responsive bonds or compartment for intracellular drug delivery and release in glioma treatment by designing the architecture of the polymer.
[Mh] Termos MeSH primário: Antineoplásicos/química
Caproatos/química
Doxorrubicina/química
Doxorrubicina/farmacologia
Glioma/tratamento farmacológico
Lactonas/química
Oxazóis/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Transporte Biológico/fisiologia
Barreira Hematoencefálica/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Portadores de Fármacos/química
Sistemas de Liberação de Medicamentos/métodos
Liberação Controlada de Fármacos/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Micelas
Tamanho da Partícula
Polímeros/química
Distribuição Tecidual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Caproates); 0 (Drug Carriers); 0 (Lactones); 0 (Micelles); 0 (Oxazoles); 0 (Polymers); 56RE988L1R (caprolactone); 80168379AG (Doxorubicin); B8CD92T4P5 (2-ethyl-2-oxazoline)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2017.1402218


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[PMID]:29267346
[Au] Autor:Westrop GD; Wang L; Blackburn GJ; Zhang T; Zheng L; Watson DG; Coombs GH
[Ad] Endereço:Strathclyde Institute of Pharmacy and Biomedical Science, Strathclyde University, Glasgow, United Kingdom.
[Ti] Título:Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine.
[So] Source:PLoS One;12(12):e0189072, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Trichomonas vaginalis and Tritrichomonas foetus are pathogens that parasitise, respectively, human and bovine urogenital tracts causing disease. Using LC-MS, reference metabolomic profiles were obtained for both species and stable isotope labelling with D-[U-13C6] glucose was used to analyse central carbon metabolism. This facilitated a comparison of the metabolic pathways of T. vaginalis and T. foetus, extending earlier targeted biochemical studies. 43 metabolites, whose identities were confirmed by comparison of their retention times with authentic standards, occurred at more than 3-fold difference in peak intensity between T. vaginalis and T. foetus. 18 metabolites that were removed from or released into the medium during growth also showed more than 3-fold difference between the species. Major differences were observed in cysteine and methionine metabolism in which homocysteine, produced as a bi-product of trans-methylation, is catabolised by methionine γ-lyase in T. vaginalis but converted to cystathionine in T. foetus. Both species synthesise methylthioadenosine by an unusual mechanism, but it is not used as a substrate for methionine recycling. T. vaginalis also produces and exports high levels of S-methylcysteine, whereas only negligible levels were found in T. foetus which maintains significantly higher intracellular levels of cysteine. 13C-labeling confirmed that both cysteine and S-methylcysteine are synthesised by T. vaginalis; S-methylcysteine can be generated by recombinant T. vaginalis cysteine synthase using phosphoserine and methanethiol. T. foetus contained higher levels of ornithine and citrulline than T. vaginalis and exported increased levels of putrescine, suggesting greater flux through the arginine dihydrolase pathway. T. vaginalis produced and exported hydroxy acid derivatives of certain amino acids, particularly 2-hydroxyisocaproic acid derived from leucine, whereas negligible levels of these metabolites occurred in T. foetus.
[Mh] Termos MeSH primário: Aminoácidos/metabolismo
Caproatos/metabolismo
Cistationina/biossíntese
Cisteína/análogos & derivados
Metabolômica
Trichomonas vaginalis/metabolismo
Tritrichomonas foetus/metabolismo
[Mh] Termos MeSH secundário: Animais
Bovinos
Cromatografia Líquida
Cisteína/biossíntese
Glicólise
Seres Humanos
Marcação por Isótopo
Espectrometria de Massas
Trichomonas vaginalis/genética
Tritrichomonas foetus/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Caproates); 375YFJ481O (Cystathionine); 498-36-2 (alpha-hydroxyisocaproic acid); A34I1H07YM (S-methylcysteine); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189072


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[PMID]:29236389
[Au] Autor:Holota YV; Holubenko OO; Ostapchuk AM; Serhiychuk TM; Zakordonets LV; Tolstanova GM
[Ti] Título:Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats.
[So] Source:Ukr Biochem J;89(1):50-8, 2017 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Short-chain fatty acids (SCFAs) are major products of the microbial fermentation of dietary fiber in the colon. Recent studies suggest that these products of microbial metabolism in the gut act as signaling molecules, influence host energy homeostasis and play major immunological roles. In the present study, defined the long-term effects of ceftriaxone administration on the fecal SCFAs concentration in Wistar rats. Ceftriaxone (300 mg/kg, i.m.) was administered daily for 14 days. Rats were euthanized in 1, 15 and 56 days after ceftriaxone withdrawal. Caecal weight and fecal concentration of SCFAs by gas chromatography were measured. Ceftriaxone administration induced time-dependent rats' caecal enlargement through accumulation of undigestable substances. In 1 day after ceftriaxone withdrawal, the concentrations of acetic, propionic, butyric acids and total SCFAs were decreased 2.9-, 13.8-, 8.5-, 4.8-fold (P < 0.05), respectively. Concentration of valeric, isovaleric and caproic acids was below the detectable level. That was accompanied by decreased 4.3-fold anaerobic index and increased the relative amount of acetic acid (P < 0.05). In 56 days, concentration of SCFAs was still below control value but higher than in 1 day (except propionic acid). Anaerobic index was lower 1.3-fold (P < 0.05) vs. control. Conclusion: antibiotic therapy induced long-term disturbance in colonic microbiota metabolic activity.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Ceftriaxona/farmacologia
Colo/efeitos dos fármacos
Ácidos Graxos Voláteis/metabolismo
Fezes/química
[Mh] Termos MeSH secundário: Ácido Acético/metabolismo
Animais
Butiratos/metabolismo
Caproatos/metabolismo
Colo/metabolismo
Esquema de Medicação
Ácidos Graxos Voláteis/antagonistas & inibidores
Injeções Intramusculares
Masculino
Ácidos Pentanoicos/metabolismo
Propionatos/metabolismo
Ratos
Ratos Wistar
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Butyrates); 0 (Caproates); 0 (Fatty Acids, Volatile); 0 (Pentanoic Acids); 0 (Propionates); 1BR7X184L5 (isovaleric acid); 1F8SN134MX (hexanoic acid); 75J73V1629 (Ceftriaxone); GZK92PJM7B (n-pentanoic acid); JHU490RVYR (propionic acid); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj89.01.050


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[PMID]:28456470
[Au] Autor:Arikawa H; Sato S; Fujiki T; Matsumoto K
[Ad] Endereço:GP Group, Corporate R&D Planning and Administration Division, Kaneka Corporation, 1-8 Miyamae-Cho, Takasago-Cho, Takasago, Hyogo 676-8688, Japan. Electronic address: Hisashi.Arikawa@kaneka.co.jp.
[Ti] Título:Simple and rapid method for isolation and quantitation of polyhydroxyalkanoate by SDS-sonication treatment.
[So] Source:J Biosci Bioeng;124(2):250-254, 2017 Aug.
[Is] ISSN:1347-4421
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We developed a new method for isolation and quantitation of polyhydroxyalkanoate (PHA) from culture broth. In this method, the cells were sonicated in sodium dodecyl sulfate (SDS) solution and centrifuged to recover PHA. The recovered PHA was rinsed with deionized water and ethanol, and then weighed after drying. Hazardous chemicals such as chloroform, methanol, and sulfuric acid were not used, and no expensive analytical instruments were needed. We applied this method to Cupriavidus necator culture broths that included various amounts of poly(3-hydroxybutyrate) (PHB) or poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) from flasks and jar fermentors. The quantitation by this method was practical for use with a wide range of production amounts and PHA monomer compositions compared to the conventional whole-cell methanolysis method with gas chromatographic analysis, and besides, the recovered PHAs were adequately pure (≥96% purity). Therefore, this new method would be valuable not only for quantitation of PHA but also for preparation of samples to characterize their mechanical properties.
[Mh] Termos MeSH primário: Cupriavidus necator/química
Poli-Hidroxialcanoatos/análise
Poli-Hidroxialcanoatos/isolamento & purificação
Sonicação/métodos
[Mh] Termos MeSH secundário: Ácido 3-Hidroxibutírico
Caproatos
Cupriavidus necator/metabolismo
Poli-Hidroxialcanoatos/metabolismo
Dodecilsulfato de Sódio/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caproates); 0 (Polyhydroxyalkanoates); 0 (poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)); 368GB5141J (Sodium Dodecyl Sulfate); TZP1275679 (3-Hydroxybutyric Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29191318
[Au] Autor:Eriksson U; Haglund P; Kärrman A
[Ad] Endereço:Man-Technology-Environment (MTM) Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden. Electronic address: ulrika.eriksson@oru.se.
[Ti] Título:Contribution of precursor compounds to the release of per- and polyfluoroalkyl substances (PFASs) from waste water treatment plants (WWTPs).
[So] Source:J Environ Sci (China);61:80-90, 2017 Nov.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Per- and polyfluoroalkyl substances (PFASs) are ubiquitous in sludge and water from waste water treatment plants, as a result of their incorporation in everyday products and industrial processes. In this study, we measured several classes of persistent PFASs, precursors, transformation intermediates, and newly identified PFASs in influent and effluent sewage water and sludge from three municipal waste water treatment plants in Sweden, sampled in 2015. For sludge, samples from 2012 and 2014 were analyzed as well. Levels of precursors in sludge exceeded those of perfluoroalkyl acids and sulfonic acids (PFCAs and PFSAs), in 2015 the sum of polyfluoroalkyl phosphoric acid esters (PAPs) were 15-20ng/g dry weight, the sum of fluorotelomer sulfonic acids (FTSAs) was 0.8-1.3ng/g, and the sum of perfluorooctane sulfonamides and ethanols ranged from non-detected to 3.2ng/g. Persistent PFSAs and PFCAs were detected at 1.9-3.9ng/g and 2.4-7.3ng/g dry weight, respectively. The influence of precursor compounds was further demonstrated by an observed substantial increase for a majority of the persistent PFCAs and PFSAs in water after waste water treatment. Perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) had a net mass increase in all WWTPs, with mean values of 83%, 28%, 37% and 58%, respectively. The load of precursors and intermediates in influent water and sludge combined with net mass increase support the hypothesis that degradation of precursor compounds is a significant contributor to PFAS contamination in the environment.
[Mh] Termos MeSH primário: Fluorcarbonetos/análise
Eliminação de Resíduos Líquidos/estatística & dados numéricos
Águas Residuais/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Ácidos Alcanossulfônicos/análise
Caproatos/análise
Caprilatos/análise
Monitoramento Ambiental
Esgotos
Suécia
Águas Residuais/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Caproates); 0 (Caprylates); 0 (Fluorocarbons); 0 (Sewage); 0 (Waste Water); 0 (Water Pollutants, Chemical); 6P60ZBK0QL (perfluorooctane); 947VD76D3L (perfluorooctanoic acid); 9H2MAI21CL (perfluorooctane sulfonic acid); ZP34Q2220R (perfluorohexanoic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28456078
[Au] Autor:Liu Y; He P; Shao L; Zhang H; Lü F
[Ad] Endereço:State Key Laboratory of Pollution Control and Resources Reuse, Tongji University, Shanghai 200092, China; Institute of Waste Treatment and Reclamation, Tongji University, Shanghai 200092, China.
[Ti] Título:Significant enhancement by biochar of caproate production via chain elongation.
[So] Source:Water Res;119:150-159, 2017 08 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, biochar was introduced into a chain elongation system to enhance the bioproduction of caproate and caprylate. The concentration of caproate increased to 21.1 g/L upon the addition of biochar, which is the highest level of caproate reported for such a system to date when ethanol was used as electron donor. The addition of biochar created a tougher system with more stable microorganism community structure for chain elongation, in which no obvious inhibition by products or substrates was observed, moreover, the lag phase was reduced 2.3-fold compared to the system without biochar. These reinforcement effect of biochar are attributed to the enhanced conductivity due to the significant enrichment of functional microorganisms via the microbial network surrounding smaller biochar particles, and via the adsorption on the rough surfaces or pores of larger particles, which facilitated electron transfer. Higher amounts of extracellular polymer substances and higher conductivity induced by biochar could contribute to the reinforcement effect in chain elongation.
[Mh] Termos MeSH primário: Caproatos
Carvão Vegetal
[Mh] Termos MeSH secundário: Adsorção
Etanol
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caproates); 0 (biochar); 16291-96-6 (Charcoal); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE



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