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[PMID]:29368826
[Au] Autor:Lauffer A; Lutz P; Flesher SL
[Ti] Título:Baylisascaris Procyonis Exposure Case Study.
[So] Source:W V Med J;112(6):32-3, 2016 Nov-Dec.
[Is] ISSN:0043-3284
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a case of exposure to raccoon feces found to be contaminated with baylisascaris procyonis. The exposure was recognized early enough by the family to allow prophylaxis with albendazole. Because of the potential fatal or neurologically catastrophic effects of this disease immediate treatment is indicated. This is started in advance of environmental studies that are done to determine if the feces is indeed contaminated.
[Mh] Termos MeSH primário: Albendazol
Anti-Helmínticos
Infecções por Ascaridida/veterinária
Ascaridídios
Guaxinins/parasitologia
[Mh] Termos MeSH secundário: Adulto
Albendazol/uso terapêutico
Animais
Anti-Helmínticos/uso terapêutico
Anticorpos Anti-Helmínticos/sangue
Ascaridídios/imunologia
Ascaridídios/isolamento & purificação
Infecções por Ascaridida/sangue
Infecções por Ascaridida/diagnóstico
Infecções por Ascaridida/tratamento farmacológico
Criança
Fezes/parasitologia
Seres Humanos
Masculino
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Antibodies, Helminth); F4216019LN (Albendazole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29329288
[Au] Autor:Pabalan N; Singian E; Tabangay L; Jarjanazi H; Boivin MJ; Ezeamama AE
[Ad] Endereço:Center for Research and Development, Angeles University Foundation, Angeles City, Philippines.
[Ti] Título:Soil-transmitted helminth infection, loss of education and cognitive impairment in school-aged children: A systematic review and meta-analysis.
[So] Source:PLoS Negl Trop Dis;12(1):e0005523, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evidence of an adverse influence of soil transmitted helminth (STH) infections on cognitive function and educational loss is equivocal. Prior meta-analyses have focused on randomized controlled trials only and have not sufficiently explored the potential for disparate influence of STH infection by cognitive domain. We re-examine the hypothesis that STH infection is associated with cognitive deficit and educational loss using data from all primary epidemiologic studies published between 1992 and 2016. METHODS: Medline, Biosis and Web of Science were searched for original studies published in the English language. Cognitive function was defined in four domains (learning, memory, reaction time and innate intelligence) and educational loss in two domains (attendance and scholastic achievement). Pooled effect across studies were calculated as standardized mean differences (SMD) to compare cognitive and educational measures for STH infected/non-dewormed children versus STH uninfected /dewormed children using Review Manager 5.3. Sub-group analyses were implemented by study design, risk of bias (ROB) and co-prevalence of Schistosoma species infection. Influential studies were excluded in sensitivity analysis to examine stability of pooled estimates. FINDINGS: We included 36 studies of 12,920 children. STH infected/non-dewormed children had small to moderate deficits in three domains-learning, memory and intelligence (SMD: -0.44 to -0.27, P<0.01-0.03) compared to STH-uninfected/dewormed children. There were no differences by infection/treatment status for reaction time, school attendance and scholastic achievement (SMD: -0.26 to -0.16, P = 0.06-0.19). Heterogeneity of the pooled effects in all six domains was high (P<0.01; I2 = 66-99%). Application of outlier treatment reduced heterogeneity in learning domain (P = 0.12; I2 = 33%) and strengthened STH-related associations in all domains but intelligence (SMD: -0.20, P = 0.09). Results varied by study design and ROB. Among experimental intervention studies, there was no association between STH treatment and educational loss/performance in tests of memory, reaction time and innate intelligence (SMD: -0.27 to 0.17, P = 0.18-0.69). Infection-related deficits in learning persisted within design/ROB levels (SMD: -0.37 to -52, P<0.01) except for pre-vs post intervention design (n = 3 studies, SMD = -0.43, P = 0.47). Deficits in memory, reaction time and innate intelligence persisted within observational studies (SMD: -0.23 to -0.38, all P<0.01) and high ROB strata (SMD:-0.37 to -0.83, P = 0.07 to <0.01). Further, in Schistosoma infection co-prevalent settings, associations were generally stronger and statistically robust for STH-related deficits in learning, memory and reaction time tests(SMD:-0.36 to -0.55, P = 0.003-0.02). STH-related deficits in school attendance and scholastic achievement was noted in low (SMD:-0.57, P = 0.05) and high ROB strata respectively. INTERPRETATION: We provide evidence of superior performance in five of six educational and cognitive domains assessed for STH uninfected/dewormed versus STH infected/not-dewormed school-aged children from helminth endemic regions. Cautious interpretation is warranted due to high ROB in some of the primary literature and high between study variability in most domains. Notwithstanding, this synthesis provides empirical support for a cognitive and educational benefit of deworming. The benefit of deworming will be enhanced by strategically employing, integrated interventions. Thus, multi-pronged inter-sectoral strategies that holistically address the environmental and structural roots of child cognitive impairment and educational loss in the developing world may be needed to fully realize the benefit of mass deworming programs.
[Mh] Termos MeSH primário: Disfunção Cognitiva/parasitologia
Testes de Memória e Aprendizagem
Esquistossomose/patologia
Esquistossomose/transmissão
Solo/parasitologia
[Mh] Termos MeSH secundário: Adolescente
Albendazol/uso terapêutico
Animais
Anti-Helmínticos/uso terapêutico
Criança
Pré-Escolar
Cognição/fisiologia
Avaliação Educacional
Função Executiva/fisiologia
Seres Humanos
Mebendazol/uso terapêutico
Schistosoma/isolamento & purificação
Esquistossomose/tratamento farmacológico
Esquistossomose/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005523


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[PMID]:27776379
[Au] Autor:Kadihasanoglu M; Kilciler M; Atahan O
[Ad] Endereço:Department of Urology, Istanbul Training and Research Hospital, Istanbul Turkey.
[Ti] Título:Endoscopic Treatment of Renal Hydatid Cyst with Percutaneous Access through an All Seeing Needle.
[So] Source:Aktuelle Urol;47(6):494-496, 2016 12.
[Is] ISSN:1438-8820
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A 44-year-old woman, who had had left flank pain for the previous 3 months, was treated successfully for renal hydatid cyst disease by using an endoscopic technique with percutaneous access through an all seeing needle. Abdominal ultrasonography showed a Gharbi type III cyst in the lower pole of the left kidney. Computerised tomography of the abdomen revealed a bulky solid-cystic mass with calcified and well-defined wall and daughter cyst without contrast enhancement. The patient, who refused any renal operation, underwent a percutaneous intervention with access through an all seeing needle access. There were no intraoperative or early postoperative complications. To our knowledge, this is the first published report of this minimally invasive percutaneous access technique through an all seeing needle.
[Mh] Termos MeSH primário: Equinococose/cirurgia
Nefropatias/cirurgia
Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação
Agulhas
Nefrostomia Percutânea/instrumentação
[Mh] Termos MeSH secundário: Adulto
Albendazol/uso terapêutico
Terapia Combinada
Equinococose/diagnóstico por imagem
Desenho de Equipamento
Feminino
Fluoroscopia
Seres Humanos
Nefropatias/diagnóstico por imagem
Sucção/instrumentação
Tomografia Computadorizada por Raios X
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
F4216019LN (Albendazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29253862
[Au] Autor:Luroni LT; Gabriel M; Tukahebwa E; Onapa AW; Tinkitina B; Tukesiga E; Nyaraga M; Auma AM; Habomugisha P; Byamukama E; Oguttu D; Katabarwa M; Unnasch TR
[Ad] Endereço:Vector Control Division, Ministry of Health, Kampala, Uganda.
[Ti] Título:The interruption of Onchocerca volvulus and Wuchereria bancrofti transmission by integrated chemotherapy in the Obongi focus, North Western Uganda.
[So] Source:PLoS One;12(12):e0189306, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTERVENTION: Few studies have documented the interruption of onchocerciasis and Lymphatic Filariasis (LF) by integrated chemotherapy in Uganda. The study describes the interruption of transmission of the two diseases co-endemic in Obongi focus, north western Uganda. Base line data for Onchocerciasis and LF were collected in 1994 and 2006, respectively. Annual mass drug administration for onchocerciasis (Ivermectin) and Lymphatic Filariasis (Ivermectin + albendazole) was conducted for 20 and 6 years, respectively. Thereafter, assessments by skin snip, larval searches in rivers and human landing catches were performed. Children <10 years were screened for IgG4 antibodies using Ov16 ELISA technique in 2013. LF Pre-TAS and TAS1 were conducted in sentinel sites. ITN coverage and utilization for the implementation unit was also reported. INTERVENTION COVERAGE: Onchocerciasis treatment coverage was <80% but improved with the introduction of CDTI in 1999. While for LF, effective coverage of >65% was achieved in the six treatment rounds. Household ownership of ITN's and utilization was 96% and 72.4%., respectively. IMPACT: Parasitological examinations conducted for onchocerciasis among 807 adults and children, revealed a reduction in mf prevalence from 58% in 1994 to 0% in 2012. Entomological monitoring conducted at the two sites had no single Simulium damnosum fly caught. Serological analysis using Ov16 ELISA for onchocerciasis revealed that out of the 3,308 children <10 years old screened in 2013, only 3/3308 (0.091%) positive cases were detected. All Ov16 positive children were negative when tested for patent infection by skin snip PCR. A reduction in LF microfilaria prevalence from 2.5% (n = 13/522) in 2006 to 0.0% (n = 602) in 2014 was observed. LF TAS1 conducted in 2015 among 1,532 children 6-7 years, all were negative for antigens of W. bancrofti. CONCLUSION: The results concluded that interruption of onchocerciasis and LF has been achieved.
[Mh] Termos MeSH primário: Antiparasitários/uso terapêutico
Filariose Linfática/tratamento farmacológico
Onchocerca volvulus
Oncocercose/tratamento farmacológico
Wuchereria bancrofti
[Mh] Termos MeSH secundário: Adolescente
Albendazol/administração & dosagem
Animais
Criança
Pré-Escolar
Filariose Linfática/epidemiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Imunoglobulina G/sangue
Ivermectina/administração & dosagem
Masculino
Oncocercose/epidemiologia
Prevalência
Uganda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Immunoglobulin G); 70288-86-7 (Ivermectin); F4216019LN (Albendazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189306


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[PMID]:29218962
[Ti] Título:Schistosomiasis and soil-transmitted helminthiases: number of people treated in 2016.
[Ti] Título:Schistosomiase et géohelminthiases: nombre de personnes traitées en 2016..
[So] Source:Wkly Epidemiol Rec;92(49):749-60, 2017 Dec 08.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Helmintíase/tratamento farmacológico
Helmintíase/epidemiologia
Mebendazol/uso terapêutico
Esquistossomose/tratamento farmacológico
Esquistossomose/epidemiologia
Solo/parasitologia
[Mh] Termos MeSH secundário: Adulto
África/epidemiologia
Albendazol/uso terapêutico
Américas/epidemiologia
Ásia/epidemiologia
Criança
Pré-Escolar
Feminino
Helmintíase/transmissão
Seres Humanos
Lactente
Masculino
Região do Mediterrâneo/epidemiologia
Praziquantel/uso terapêutico
Esquistossomose/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil); 6490C9U457 (Praziquantel); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29059186
[Au] Autor:Kar SK; Dwibedi B; Das BK; Agrawala BK; Ramachandran CP; Horton J
[Ad] Endereço:Director of Medical Research, IMS & Sum Hospital, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.
[Ti] Título:Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment.
[So] Source:PLoS Negl Trop Dis;11(10):e0005631, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Once interruption of transmission of lymphatic filariasis is achieved, morbidity prevention and management becomes more important. A study in Brugia malayi filariasis from India has shown sub-clinical lymphatic pathology with potential reversibility. We studied a Wuchereria bancrofti infected population, the major contributor to LF globally. METHODS: Children aged 5-18 years from Odisha, India were screened for W. bancrofti infection and disease. 102 infected children, 50 with filarial disease and 52 without symptoms were investigated by lymphoscintigraphy and then randomized to receive a supervised single oral dose of DEC and albendazole which was repeated either annually or semi-annually. The lymphatic pathology was evaluated six monthly for two years. FINDINGS: Baseline lymphoscintigraphy showed abnormality in lower limb lymphatics in 80% of symptomatic (40/50) and 63·5% (33/52) of asymptomatic children. Progressive improvement in baseline pathology was seen in 70·8, 87·3, 98·6, and 98·6% of cases at 6, 12, 18, and 24 months follow up, while in 4·2, 22·5, 47·9 and 64·8%, pathology reverted to normal. This was independent of age (p = 0·27), symptomatic status (p = 0·57) and semi-annual/bi-annual dosing (p = 0·46). Six of eleven cases showed clinical reduction in lymphedema of legs. INTERPRETATION: A significant proportion of a young W. bancrofti infected population exhibited lymphatic pathology which was reversible with annual dosage of DEC and albendazole. This provides evidence for morbidity prevention & treatment of early lymphedema. It can also be used as a tool to improve community compliance during mass drug administration. TRIAL REGISTRATION: ClinicalTrials.gov No CTRI/2013/10/004121.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Dietilcarbamazina/uso terapêutico
Filariose Linfática/tratamento farmacológico
Filariose Linfática/patologia
Filaricidas/uso terapêutico
Sistema Linfático/patologia
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Albendazol/administração & dosagem
Animais
Infecções Assintomáticas
Criança
Pré-Escolar
Dietilcarbamazina/administração & dosagem
Filariose Linfática/parasitologia
Feminino
Seres Humanos
Índia
Linfedema/tratamento farmacológico
Linfedema/parasitologia
Linfocintigrafia
Masculino
Resultado do Tratamento
Wuchereria bancrofti/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Filaricides); F4216019LN (Albendazole); V867Q8X3ZD (Diethylcarbamazine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005631


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[PMID]:28991899
[Au] Autor:Echazú A; Juarez M; Vargas PA; Cajal SP; Cimino RO; Heredia V; Caropresi S; Paredes G; Arias LM; Abril M; Gold S; Lammie P; Krolewiecki AJ
[Ad] Endereço:Instituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta-Sede Regional Orán, San Ramón de la Nueva Orán, Salta, Argentina.
[Ti] Título:Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study.
[So] Source:PLoS Negl Trop Dis;11(10):e0006003, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S. stercoralis and hookworm. METHODOLOGY: Community-based pragmatic trial conducted in Tartagal, Argentina; from 2012 to 2015. Six communities (5070 people) were enrolled for community-based PC with albendazole and ivermectin. Two communities (2721 people) were re-treated for second and third rounds. STH prevalence, anemia and malnutrition were explored through consecutive surveys. Anthropometric assessment of children, stool analysis, complete blood count and NIE-ELISA serology for S. stercoralis were performed. PRINCIPAL FINDINGS: STH infection was associated with anemia and stunting in the baseline survey that included all communities and showed a STH prevalence of 47.6% (almost exclusively hookworm and S. stercoralis). Among communities with multiple interventions, STH prevalence decreased from 62% to 23% (p<0.001) after the first PC; anemia also diminished from 52% to 12% (p<0.001). After two interventions S. stercoralis seroprevalence declined, from 51% to 14% (p<0.001) and stunting prevalence decreased, from 19% to 12% (p = 0.009). CONCLUSIONS: Hookworm' infections are associated with anemia in the general population and nutritional impairment in children. S. stercoralis is also associated with anemia. Community-based deworming with albendazole and ivermectin is effective for the reduction of STH prevalence and morbidity in communities with high prevalence of hookworm and S. stercoralis.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Ancylostomatoidea
Infecções por Uncinaria/tratamento farmacológico
Ivermectina/uso terapêutico
Strongyloides stercoralis
Estrongiloidíase/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Anti-Helmínticos/uso terapêutico
Argentina/epidemiologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Prevalência
Solo/parasitologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil); 70288-86-7 (Ivermectin); F4216019LN (Albendazole)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006003


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[PMID]:28984121
[Ti] Título:Global programme to eliminate lymphatic filariasis: progress report, 2016.
[Ti] Título:Programme mondial pour l'élimination de la filariose lymphatique: rapport de situation, 2016..
[So] Source:Wkly Epidemiol Rec;92(40):594-607, 2017 10 06.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Erradicação de Doenças
Filariose Linfática/prevenção & controle
Saúde Global
Doenças Negligenciadas/prevenção & controle
[Mh] Termos MeSH secundário: Albendazol/administração & dosagem
Dietilcarbamazina/administração & dosagem
Erradicação de Doenças/organização & administração
Erradicação de Doenças/estatística & dados numéricos
Quimioterapia Combinada/métodos
Filariose Linfática/tratamento farmacológico
Filariose Linfática/epidemiologia
Doenças Endêmicas/prevenção & controle
Doenças Endêmicas/estatística & dados numéricos
Seres Humanos
Ivermectina/administração & dosagem
Loíase/tratamento farmacológico
Loíase/epidemiologia
Loíase/prevenção & controle
Doenças Negligenciadas/tratamento farmacológico
Doenças Negligenciadas/epidemiologia
Oncocercose/tratamento farmacológico
Oncocercose/epidemiologia
Oncocercose/prevenção & controle
Avaliação de Programas e Projetos de Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 70288-86-7 (Ivermectin); F4216019LN (Albendazole); V867Q8X3ZD (Diethylcarbamazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28942047
[Au] Autor:Kotková M; Sak B; Hlásková L; Kvác M
[Ad] Endereço:Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in Ceské Budejovice, Ceské Budejovice, Czech Republic.
[Ti] Título:The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice.
[So] Source:Exp Parasitol;182:16-21, 2017 Nov.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Encephalitozoon cuniculi/fisiologia
Encefalitozoonose/imunologia
Imunocompetência
Hospedeiro Imunocomprometido
[Mh] Termos MeSH secundário: Albendazol/farmacologia
Animais
Antifúngicos/farmacologia
Antifúngicos/uso terapêutico
Encephalitozoon cuniculi/efeitos dos fármacos
Encephalitozoon cuniculi/genética
Encephalitozoon cuniculi/imunologia
Encefalitozoonose/tratamento farmacológico
Encefalitozoonose/parasitologia
Fezes/parasitologia
Genótipo
Camundongos
Camundongos Endogâmicos BALB C
Camundongos SCID
Esporos Fúngicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); F4216019LN (Albendazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28922418
[Au] Autor:Lau CL; Sheridan S; Ryan S; Roineau M; Andreosso A; Fuimaono S; Tufa J; Graves PM
[Ad] Endereço:Department of Global Health, Research School of Population Health, The Australian National University, Canberra, Australia.
[Ti] Título:Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping mass drug administration.
[So] Source:PLoS Negl Trop Dis;11(9):e0005914, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Global Programme to Eliminate Lymphatic Filariasis (LF) aims to eliminate the disease as a public health problem by 2020 by conducting mass drug administration (MDA) and controlling morbidity. Once elimination targets have been reached, surveillance is critical for ensuring that programmatic gains are sustained, and challenges include timely identification of residual areas of transmission. WHO guidelines encourage cost-efficient surveillance, such as integration with other population-based surveys. In American Samoa, where LF is caused by Wuchereria bancrofti, and Aedes polynesiensis is the main vector, the LF elimination program has made significant progress. Seven rounds of MDA (albendazole and diethycarbamazine) were completed from 2000 to 2006, and Transmission Assessment Surveys were passed in 2010/2011 and 2015. However, a seroprevalence study using an adult serum bank collected in 2010 detected two potential residual foci of transmission, with Og4C3 antigen (Ag) prevalence of 30.8% and 15.6%. We conducted a follow up study in 2014 to verify if transmission was truly occurring by comparing seroprevalence between residents of suspected hotspots and residents of other villages. In adults from non-hotspot villages (N = 602), seroprevalence of Ag (ICT or Og4C3), Bm14 antibody (Ab) and Wb123 Ab were 1.2% (95% CI 0.6-2.6%), 9.6% (95% CI 7.5%-12.3%), and 10.5% (95% CI 7.6-14.3%), respectively. Comparatively, adult residents of Fagali'i (N = 38) had significantly higher seroprevalence of Ag (26.9%, 95% CI 17.3-39.4%), Bm14 Ab (43.4%, 95% CI 32.4-55.0%), and Wb123 Ab 55.2% (95% CI 39.6-69.8%). Adult residents of Ili'ili/Vaitogi/Futiga (N = 113) also had higher prevalence of Ag and Ab, but differences were not statistically significant. The presence of transmission was demonstrated by 1.1% Ag prevalence (95% CI 0.2% to 3.1%) in 283 children aged 7-13 years who lived in one of the suspected hotspots; and microfilaraemia in four individuals, all of whom lived in the suspected hotspots, including a 9 year old child. Our results provide field evidence that integrating LF surveillance with other surveys is effective and feasible for identifying potential hotspots, and conducting surveillance at worksites provides an efficient method of sampling large populations of adults.
[Mh] Termos MeSH primário: Filariose Linfática/epidemiologia
Filariose Linfática/transmissão
Filaricidas/administração & dosagem
Wuchereria bancrofti/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Aedes/imunologia
Albendazol/administração & dosagem
Albendazol/uso terapêutico
Samoa Americana/epidemiologia
Animais
Anticorpos Anti-Helmínticos/sangue
Antígenos de Helmintos/sangue
Criança
Pré-Escolar
Dietilcarbamazina/administração & dosagem
Dietilcarbamazina/uso terapêutico
Erradicação de Doenças
Esquema de Medicação
Filariose Linfática/imunologia
Filariose Linfática/parasitologia
Feminino
Filaricidas/uso terapêutico
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Prevalência
Estudos Soroepidemiológicos
Wuchereria bancrofti/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Antigens, Helminth); 0 (Filaricides); F4216019LN (Albendazole); V867Q8X3ZD (Diethylcarbamazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005914



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