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[PMID]:26983915
[Au] Autor:Guelfi DRV; Gozzi F; Sirés I; Brillas E; Machulek A; de Oliveira SC
[Ad] Endereço:Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul, 549, Av. Senador Filinto Muller 1555, 79070-900, Campo Grande, Mato Grosso do Sul, Brazil.
[Ti] Título:Degradation of the insecticide propoxur by electrochemical advanced oxidation processes using a boron-doped diamond/air-diffusion cell.
[So] Source:Environ Sci Pollut Res Int;24(7):6083-6095, 2017 Mar.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A solution with 0.38 mM of the pesticide propoxur (PX) at pH 3.0 has been comparatively treated by electrochemical oxidation with electrogenerated H O (EO-H O ), electro-Fenton (EF), and photoelectro-Fenton (PEF). The trials were carried out with a 100-mL boron-doped diamond (BDD)/air-diffusion cell. The EO-H O process had the lowest oxidation ability due to the slow reaction of intermediates with OH produced from water discharge at the BDD anode. The EF treatment yielded quicker mineralization due to the additional OH formed between added Fe and electrogenerated H O . The PEF process was the most powerful since it led to total mineralization by the combined oxidative action of hydroxyl radicals and UVA irradiation. The PX decay agreed with a pseudo-first-order kinetics in EO-H O , whereas in EF and PEF, it obeyed a much faster pseudo-first-order kinetics followed by a much slower one, which are related to the oxidation of its Fe(II) and Fe(III) complexes, respectively. EO-H O showed similar oxidation ability within the pH range 3.0-9.0. The effect of current density and Fe and substrate contents on the performance of the EF process was examined. Two primary aromatic products were identified by LC-MS during PX degradation.
[Mh] Termos MeSH primário: Boro/química
Diamante/química
Inseticidas
Propoxur
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Inseticidas/análise
Inseticidas/química
Oxirredução
Propoxur/análise
Propoxur/química
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/química
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Water Pollutants, Chemical); 7782-40-3 (Diamond); BFH029TL73 (Propoxur); N9E3X5056Q (Boron)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6416-8


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[PMID]:27405213
[Au] Autor:Zhakhongirov ShM; Saifiev ShT; Abidov ZI
[Ti] Título:[INSECTICIDE RESISTANCE IN MAJOR MALARIA VECTORS IN UZBEKISTAN].
[So] Source:Med Parazitol (Mosk);(2):31-4, 2016 Apr-Jun.
[Is] ISSN:0025-8326
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The resistance of Anopheles artemievi to DDT (26.7%) and propoxur (80.0%) was established in the kishlak of Chubat, Bulungursky District, Samarkand Viloyati and that in the kishlak of Rastguzar, Uichinsky District, Namangan Viloyati, was 45.0 and 22.5%, respectively. In the kishlak of Navruz, Kanlikulsky District, Republic of Karakalpakstan, there was reduced propoxur susceptibil- ity (90.0% An. superpictus death); in other human settle- ments, An. artemievi was susceptible--100% death in the use of the test insecticides. An. superpictus proved to be susceptive to 7 test insecticides (other than propoxur). In Uzbekistan, the resistance of An. artemievi was noted only in a small area. Among the major malaria vectors, An. superpictus remained susceptible to pyrethroid insec- ticides.
[Mh] Termos MeSH primário: Anopheles/fisiologia
DDT
Insetos Vetores/fisiologia
Inseticidas
Propoxur
Piretrinas
[Mh] Termos MeSH secundário: Animais
Monitoramento Epidemiológico
Feminino
Seres Humanos
Resistência a Inseticidas
Malária/prevenção & controle
Malária/transmissão
Masculino
Uzbequistão
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Pyrethrins); BFH029TL73 (Propoxur); CIW5S16655 (DDT)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160713
[Lr] Data última revisão:
160713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160714
[St] Status:MEDLINE


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[PMID]:27151229
[Au] Autor:Yeebiyo Y; Dengela D; Tesfaye AG; Anshebo GY; Kolyada L; Wirtz R; Chibsa S; Fornadel C; George K; Belemvire A; Taffese HS; Lucas B
[Ad] Endereço:The President's Malaria Initiative Africa Indoor Residual Spraying Project, Abt Associates, Gerji Road, Sami Building, 1st Floor, Addis Ababa, Ethiopia.
[Ti] Título:Short persistence of bendiocarb sprayed on pervious walls and its implication for the indoor residual spray program in Ethiopia.
[So] Source:Parasit Vectors;9:266, 2016 May 05.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: With the emergence and spread of vector resistance to pyrethroids and DDT in Africa, several countries have recently switched or are considering switching to carbamates and/or organophosphates for indoor residual spraying (IRS). However, data collected on the residual life of bendiocarb used for IRS in some areas indicate shorter than expected bio-efficacy. This study evaluated the effect of pH and wall type on the residual life of the carbamates bendiocarb and propoxur as measured by the standard World Health Organization (WHO) cone bioassay test. METHODS: In phase I of this study, bendiocarb and propoxur were mixed with buffered low pH (pH 4.3) local water and non-buffered high pH (pH 8.0) local water and sprayed on two types of wall surface, mud and dung, in experimental huts. In the six month phase II study, the two insecticides were mixed with high pH local water and sprayed on four different surfaces: painted, dung, mud and mud pre-wetted with water. The residual bio-efficacy of the insecticides was assessed monthly using standard WHO cone bioassay tests. RESULTS: In phase I, bendiocarb mixed with high pH water killed more than 80% of susceptible Anopheles arabiensis mosquitoes for two months on both dung and mud surfaces. On dung surfaces, the 80% mortality threshold was achieved for three months when the bendiocarb was mixed with low pH water and four months when it was mixed with high pH water. Propoxur lasted longer than bendiocarb on dung surfaces, staying above the 80% mortality threshold for four and five months when mixed with high and low pH water, respectively. Phase II results also showed that the type of surface sprayed has a significant impact on the bio-efficacy of bendiocarb. Keeping the spray water constant at the same high pH of 8.0, bendiocarb killed 100% of exposed mosquitoes on impervious painted surfaces for the six months of the study period compared with less than one month on mud surfaces. CONCLUSIONS: Mixing the insecticides in alkaline water did not reduce the residual bio-efficacy of bendiocarb. However, bendiocarb performed much better on impervious (painted) surfaces than on porous dung or mud ones. Propoxur was less affected by wall type than was bendiocarb. Studies on the interaction between wall materials, soil, humidity, temperature and pH and the residual bio-efficacy of new and existing insecticides are recommended prior to their wide use in IRS.
[Mh] Termos MeSH primário: Inseticidas/química
Fenilcarbamatos/química
[Mh] Termos MeSH secundário: Animais
Anopheles/efeitos dos fármacos
Etiópia
Fezes
Habitação
Resíduos de Praguicidas/química
Propoxur/química
Solo/química
Propriedades de Superfície
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Pesticide Residues); 0 (Phenylcarbamates); 0 (Soil); 059QF0KO0R (Water); BFH029TL73 (Propoxur); QFH0ZU0A5U (bendiocarb)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-016-1549-7


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[PMID]:27029555
[Au] Autor:Shahid M; Takamiya M; Stegmaier J; Middel V; Gradl M; Klüver N; Mikut R; Dickmeis T; Scholz S; Rastegar S; Yang L; Strähle U
[Ad] Endereço:Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Postfach 3640, D76021 Karlsruhe.
[Ti] Título:Zebrafish biosensor for toxicant induced muscle hyperactivity.
[So] Source:Sci Rep;6:23768, 2016 Mar 31.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Robust and sensitive detection systems are a crucial asset for risk management of chemicals, which are produced in increasing number and diversity. To establish an in vivo biosensor system with quantitative readout for potential toxicant effects on motor function, we generated a transgenic zebrafish line TgBAC(hspb11:GFP) which expresses a GFP reporter under the control of regulatory elements of the small heat shock protein hspb11. Spatiotemporal hspb11 transgene expression in the musculature and the notochord matched closely that of endogenous hspb11 expression. Exposure to substances that interfere with motor function induced a dose-dependent increase of GFP intensity beginning at sub-micromolar concentrations, while washout of the chemicals reduced the level of hspb11 transgene expression. Simultaneously, these toxicants induced muscle hyperactivity with increased calcium spike height and frequency. The hspb11 transgene up-regulation induced by either chemicals or heat shock was eliminated after co-application of the anaesthetic MS-222. TgBAC(hspb11:GFP) zebrafish embryos provide a quantitative measure of muscle hyperactivity and represent a robust whole organism system for detecting chemicals that affect motor function.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Proteínas de Fluorescência Verde/genética
Peptídeos e Proteínas de Sinalização Intracelular/genética
Atividade Motora/efeitos dos fármacos
Músculos/efeitos dos fármacos
Proteínas Mutantes Quiméricas/genética
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Azinfos-Metil/análise
Azinfos-Metil/toxicidade
Relação Dose-Resposta a Droga
Efeito Fundador
Galantamina/análise
Galantamina/toxicidade
Regulação da Expressão Gênica
Proteínas de Fluorescência Verde/agonistas
Proteínas de Fluorescência Verde/antagonistas & inibidores
Proteínas de Fluorescência Verde/metabolismo
Peptídeos e Proteínas de Sinalização Intracelular/agonistas
Peptídeos e Proteínas de Sinalização Intracelular/antagonistas & inibidores
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Músculos/metabolismo
Proteínas Mutantes Quiméricas/agonistas
Proteínas Mutantes Quiméricas/antagonistas & inibidores
Proteínas Mutantes Quiméricas/metabolismo
Notocorda/efeitos dos fármacos
Notocorda/metabolismo
Praguicidas/análise
Praguicidas/toxicidade
Regiões Promotoras Genéticas
Propoxur/análise
Propoxur/toxicidade
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HSPB11 protein, human); 0 (Intracellular Signaling Peptides and Proteins); 0 (Mutant Chimeric Proteins); 0 (Pesticides); 0D3Q044KCA (Galantamine); 147336-22-9 (Green Fluorescent Proteins); 265842EWUV (Azinphosmethyl); BFH029TL73 (Propoxur)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.1038/srep23768


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[PMID]:26921225
[Au] Autor:Shan C; Zhang Y; Ma Z; Gao X
[Ti] Título:Inheritance of Propoxur Resistance in a Near-Isogenic Line of Musca domestica (Diptera: Muscidae).
[So] Source:J Econ Entomol;109(2):873-8, 2016 Apr.
[Is] ISSN:0022-0493
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Propoxur, a carbamate insecticide, has been used worldwide for the control of house flies (Musca domestica L.) for many decades. Resistance levels to propoxur have been detected in field populations of house flies in many parts of the world, including China. In this study, a near-isogenic house fly line (N-PRR) resistant to propoxur was used to determine the mode of inheritance. Bioassay results showed no significant differences in LD50 values or in the slope of log dose-probit lines between the reciprocal F1 and F1' progenies, and the degree of dominance (D) was more than −1 and less than 0. Chi-square analysis of the responses of self-bred (F2, F2') and backcross progenies (BC1, BC2, BC1', and BC2') indicated that a single gene was responsible for resistance. Propoxur resistance in the N-PRR strain of house fly was inherited as a single, major, autosomal, and incompletely recessive factor. These results should be useful to reveal the mode of inheritance and the development trend of propoxur resistance and develop a systematic strategy for the resistance management in house flies.
[Mh] Termos MeSH primário: Moscas Domésticas/genética
Inseticidas
Propoxur
[Mh] Termos MeSH secundário: Animais
Feminino
Padrões de Herança
Resistência a Inseticidas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); BFH029TL73 (Propoxur)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160630
[Lr] Data última revisão:
160630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160228
[St] Status:MEDLINE


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[PMID]:26802491
[Au] Autor:Li CX; Guo XX; Zhang YM; Dong YD; Xing D; Yan T; Wang G; Zhang HD; Zhao TY
[Ad] Endereço:Department of Vector Biology and Control, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing 100071, China. Electronic address: vectorlcx@126.com.
[Ti] Título:Identification of genes involved in pyrethroid-, propoxur-, and dichlorvos- insecticides resistance in the mosquitoes, Culex pipiens complex (Diptera: Culicidae).
[So] Source:Acta Trop;157:84-95, 2016 May.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Culex pipiens pallens and Cx. p. quinquefasciatus are important vectors of many diseases, such as West Nile fever and lymphatic filariasis. The widespread use of insecticides to control these disease vectors and other insect pests has led to insecticide resistance becoming common in these species. In this study, high throughout Illumina sequencing was used to identify hundreds of Cx. p. pallens and Cx. p. quinquefasciatus genes that were differentially expressed in response to insecticide exposure. The identification of these genes is a vital first step for more detailed investigation of the molecular mechanisms involved in insecticide resistance in Culex mosquitoes.
[Mh] Termos MeSH primário: Culex/efeitos dos fármacos
Culex/genética
Diclorvós/toxicidade
Resistência a Inseticidas/genética
Inseticidas/toxicidade
Propoxur/toxicidade
Piretrinas/toxicidade
[Mh] Termos MeSH secundário: Animais
China
Vetores de Doenças
Variação Genética
Larva/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Pyrethrins); 7U370BPS14 (Dichlorvos); BFH029TL73 (Propoxur)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160124
[St] Status:MEDLINE


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[PMID]:27011996
[Ti] Título:[Construction of Three-Dimensional Isobologram for Ternary Pollutant Mixtures].
[So] Source:Huan Jing Ke Xue;36(12):4574-81, 2015 Dec.
[Is] ISSN:0250-3301
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Tongji University, Shanghai 200092, China) Isobolographic analysis was widely used in the interaction assessment of binary mixtures. However, how to construct a three-dimensional (3D) isobologram for the assessment of toxicity interaction within ternary mixtures is still not reported up to date. The main purpose of this paper is to develop a 3D isobologram where the relative concentrations of three components are acted as three coordinate axes in 3D space to examine the toxicity interaction within ternary mixtures. Taking six commonly used pesticides in China, including three herbicides (2, 4-D, desmetryne and simetryn) and three insecticides ( dimethoate, imidacloprid and propoxur) as the mixture components, the uniform design ray procedure (UD-Ray) was used to rationally design the concentration composition of various components in the ternary mixtures so that effectively and comprehensively reflected the variety of actual environmental concentrations. The luminescent inhibition toxicities of single pesticides and their ternary mixtures to Vibrio fischeri at various concentration levels were determined by the microplate toxicity analysis. Selecting concentration addition (CA) as the addition reference, 3D isobolograms were constructed to study the toxicity interactions of various ternary mixtures. The results showed that the 3D isobologram could clearly and directly exhibit the toxicity interactions of ternary mixtures, and extend the use of isobolographic analysis into the ternary mixtures.
[Mh] Termos MeSH primário: Poluentes Ambientais/toxicidade
Herbicidas/toxicidade
Praguicidas/toxicidade
Testes de Toxicidade/métodos
[Mh] Termos MeSH secundário: Ácido 2,4-Diclorofenoxiacético
China
Dimetoato
Substâncias Perigosas
Imidazóis
Inseticidas
Neonicotinoides
Nitrocompostos
Propoxur
Triazinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Hazardous Substances); 0 (Herbicides); 0 (Imidazoles); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Pesticides); 0 (Triazines); 036180247V (simetryn); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); 36FZV8OVJS (semeron); 3BN7M937V8 (imidacloprid); BFH029TL73 (Propoxur); W6U08B045O (Dimethoate)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160326
[St] Status:MEDLINE


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[PMID]:26344869
[Au] Autor:Sivan A; Shriram AN; Sunish IP; Vidhya PT
[Ad] Endereço:Department of Health Research (Ministry of Health and Family Welfare, Government of India), Regional Medical Research Centre (Indian Council of Medical Research), Post Bag No.13, Port Blair, 744 101, Andaman and Nicobar Islands, India. arunsivan86@gmail.com.
[Ti] Título:Studies on insecticide susceptibility of Aedes aegypti (Linn) and Aedes albopictus (Skuse) vectors of dengue and chikungunya in Andaman and Nicobar Islands, India.
[So] Source:Parasitol Res;114(12):4693-702, 2015 Dec.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dengue and chikungunya are important arboviral infections in the Andaman Islands. Competent vectors viz. Aedes aegypti and Aedes albopictus are widely prevalent. The most effective proven method for interrupting the transmission of these arboviruses is vector control, mediated through insecticides. Currently, DDT and temephos are the insecticides used for vector control in these islands. Lack of information on susceptibility necessitated assessing the susceptibility profile of A. aegypti and A. albopictus. F1 generation of adult and larvae were assayed, and LT50 and LT90 values were interpreted following the World Health Organization (WHO) protocol. Adults were found resistant to DDT-4 % while susceptible to dieldrin-0.4 %. Against organophosphates, both showed resistance to fenitrothion but susceptible to malathion-5 %. Both species showed resistance to carbamate and bendiocarb-0.1 % while susceptible to propoxur-0.1 %. Of the four synthetic pyrethroids, both were susceptible to deltamethrin-0.05 %, while resistant to permethrin-0.75 %, lambdacyhalothrin-0.05 % and cyfluthrin-0.15 %. Larvae of both species showed resistance to temephos at 0.02 mg/L but susceptible to malathion at 1 mg/L and fenthion at 0.05 mg/L. Currently, there is no prescribed WHO dose for adult-insecticide susceptibility testing. The emergence of resistance to DDT and temephos in the vector population poses a challenge to the on-going vector control measures. The results highlight the need for monitoring resistance to insecticides in the vector population. Impetus for source reduction and alternative choices of control measures are discussed for tackling future threat of arboviral infections in these islands.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Febre de Chikungunya/transmissão
Dengue/transmissão
Insetos Vetores/efeitos dos fármacos
Inseticidas/farmacologia
[Mh] Termos MeSH secundário: Aedes/crescimento & desenvolvimento
Animais
Feminino
Seres Humanos
Índia
Insetos Vetores/crescimento & desenvolvimento
Ilhas
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Malation/farmacologia
Masculino
Nitrilos/farmacologia
Permetrina/farmacologia
Propoxur/farmacologia
Piretrinas/farmacologia
Temefós/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 509F88P9SZ (Permethrin); BFH029TL73 (Propoxur); ONP3ME32DL (Temefos); SCM2QLZ6S0 (cyfluthrin); U5N7SU872W (Malathion)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150908
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-015-4717-3


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[PMID]:26164753
[Au] Autor:Iatropoulos MJ; Duan JD; Schmuck G; Williams GM
[Ad] Endereço:New York Medical College, Valhalla, NY 10595, USA.
[Ti] Título:The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats.
[So] Source:Exp Toxicol Pathol;67(9):453-8, 2015 Sep.
[Is] ISSN:1618-1433
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Propoxur (PPX) is a carbamate insecticide which induced urinary bladder cancer in Wistar rats when fed at 5000ppm in Altromin 1321 diet (1321). In the present investigation, PPX was studied for induction of several key events related to modes of action (MOA) of carcinogenicity in urinary bladders (UBs). Wistar rats were administered the compound for 28 days at 8000ppm in Provini Liba SA 3883 diet, which is similar to the 1321 diet. o-Anisidine HCl (AH) was used as a genotoxic UB carcinogenic comparator, and trisodium nitrilotriacetate (NTA) as an epigenetic UB carcinogen comparator. Along with the non-dosed control and three test substance groups (PPX, AH, NTA), four more groups were additionally fed 2% ammonium chloride (AC) in the diet to acidify the urine, since 1321 was reported to increase urinary pH. AC did acidify the urine, as expected, although the 3883 diet itself did not increase pH values above 8. In the alkaline comet assay, AH produced DNA single strand breaks (SSBs) in the UB urothelium (UBU) irrespective of AC administration, whereas PPX and NTA did not. In the nucleotide (32)P-postlabeling assay (NPL), AH produced DNA adducts irrespective of AC administration, whereas PPX and NTA did not. Routine (H&E) histopathology evaluation of the UBU did not reveal any hyperplasia or evidence of luminal microprecipitates or calculi in any of the groups. Assessment of UBU proliferation as measured by immunohistochemistry of proliferating cell nuclear antigen, revealed that NTA and NTA plus AC increased the replicating fraction (RF). Also AH plus AC, but not AH alone, increased the RF of UBU, whereas PPX groups were not significantly different from controls. Thus, the results reveal no evidence for DNA SSBs, binding, or alteration of DNA synthesis in the UBU by PPX, while demonstrating UBU DNA damage by AH and showing that NTA does not damage DNA, but causes increased UBU proliferation. The findings are in accord with a genotoxic MOA for AH, and an epigenetic MOA for NTA. The MOA of PPX does not involve genotoxicity and may be specific to the 1321 diet.
[Mh] Termos MeSH primário: Adutos de DNA/metabolismo
Dano ao DNA
Inseticidas/toxicidade
Mutagênicos/toxicidade
Propoxur/toxicidade
Bexiga Urinária/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Proliferação Celular/efeitos dos fármacos
Ensaio Cometa
Masculino
Ratos Wistar
Bexiga Urinária/metabolismo
Bexiga Urinária/patologia
Urotélio/efeitos dos fármacos
Urotélio/metabolismo
Urotélio/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Adducts); 0 (Insecticides); 0 (Mutagens); BFH029TL73 (Propoxur)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150912
[Lr] Data última revisão:
150912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150713
[St] Status:MEDLINE


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[PMID]:25961834
[Au] Autor:Abd-Ella A; Stankiewicz M; Mikulska K; Nowak W; Pennetier C; Goulu M; Fruchart-Gaillard C; Licznar P; Apaire-Marchais V; List O; Corbel V; Servent D; Lapied B
[Ad] Endereço:Laboratoire Récepteurs et Canaux Ioniques Membranaires (RCIM) UPRES EA 2647/USC INRA 1330, SFR 4207 QUASAV, Université d'Angers, UFR SCIENCES, Angers cedex, France; Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut, Egypt.
[Ti] Título:The Repellent DEET Potentiates Carbamate Effects via Insect Muscarinic Receptor Interactions: An Alternative Strategy to Control Insect Vector-Borne Diseases.
[So] Source:PLoS One;10(5):e0126406, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insect vector-borne diseases remain one of the principal causes of human mortality. In addition to conventional measures of insect control, repellents continue to be the mainstay for personal protection. Because of the increasing pyrethroid-resistant mosquito populations, alternative strategies to reconstitute pyrethroid repellency and knock-down effects have been proposed by mixing the repellent DEET (N,N-Diethyl-3-methylbenzamide) with non-pyrethroid insecticide to better control resistant insect vector-borne diseases. By using electrophysiological, biochemichal, in vivo toxicological techniques together with calcium imaging, binding studies and in silico docking, we have shown that DEET, at low concentrations, interacts with high affinity with insect M1/M3 mAChR allosteric site potentiating agonist effects on mAChRs coupled to phospholipase C second messenger pathway. This increases the anticholinesterase activity of the carbamate propoxur through calcium-dependent regulation of acetylcholinesterase. At high concentrations, DEET interacts with low affinity on distinct M1/M3 mAChR site, counteracting the potentiation. Similar dose-dependent dual effects of DEET have also been observed at synaptic mAChR level. Additionally, binding and in silico docking studies performed on human M1 and M3 mAChR subtypes indicate that DEET only displays a low affinity antagonist profile on these M1/M3 mAChRs. These results reveal a selective high affinity positive allosteric site for DEET in insect mAChRs. Finally, bioassays conducted on Aedes aegypti confirm the synergistic interaction between DEET and propoxur observed in vitro, resulting in a higher mortality of mosquitoes. Our findings reveal an unusual allosterically potentiating action of the repellent DEET, which involves a selective site in insect. These results open exciting research areas in public health particularly in the control of the pyrethroid-resistant insect-vector borne diseases. Mixing low doses of DEET and a non-pyrethroid insecticide will lead to improvement in the efficiency treatments thus reducing both the concentration of active ingredients and side effects for non-target organisms. The discovery of this insect specific site may pave the way for the development of new strategies essential in the management of chemical use against resistant mosquitoes.
[Mh] Termos MeSH primário: Carbamatos/farmacologia
DEET/farmacologia
Repelentes de Insetos/farmacologia
Receptor Muscarínico M1/metabolismo
Receptor Muscarínico M3/metabolismo
[Mh] Termos MeSH secundário: Aedes
Animais
Sinergismo Farmacológico
Seres Humanos
Insetos Vetores
Propoxur/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbamates); 0 (Insect Repellents); 0 (Receptor, Muscarinic M1); 0 (Receptor, Muscarinic M3); 134-62-3 (DEET); BFH029TL73 (Propoxur)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150512
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0126406



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