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Pesquisa : D02.241.081.337.052 [Categoria DeCS]
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  1 / 1101 MEDLINE  
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[PMID]:29364609
[Ti] Título:[Not Available.]
[So] Source:Mikrobiologiia;85(5):613-616, 2016 Sep.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Actinobacteria/metabolismo
Caprolactama/análogos & derivados
Caprolactama/metabolismo
Polímeros/metabolismo
[Mh] Termos MeSH secundário: Acetilcoenzima A/metabolismo
Actinobacteria/isolamento & purificação
Adipatos/metabolismo
Ácido Aminocaproico/metabolismo
Caproatos/metabolismo
Meios de Cultura/química
Hidrólise
Esgotos/microbiologia
Ácido Succínico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (6-oxohexanoic acid); 0 (Adipates); 0 (Caproates); 0 (Culture Media); 0 (Polymers); 0 (Sewage); 25038-54-4 (nylon 6); 6879X594Z8 (Caprolactam); 72-89-9 (Acetyl Coenzyme A); 76A0JE0FKJ (adipic acid); AB6MNQ6J6L (Succinic Acid); U6F3787206 (Aminocaproic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


  2 / 1101 MEDLINE  
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[PMID]:28392690
[Au] Autor:Jian YS; Chen CW; Lin CA; Yu HP; Lin HY; Liao MY; Wu SH; Lin YF; Lai PS
[Ad] Endereço:Department of Chemistry.
[Ti] Título:Hyaluronic acid-nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo.
[So] Source:Int J Nanomedicine;12:2315-2333, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Carrier-mediated drug delivery systems are promising therapeutics for targeted delivery and improved efficacy and safety of potent cytotoxic drugs. Nimesulide is a multifactorial cyclooxygenase 2 nonsteroidal anti-inflammatory drug with analgesic, antipyretic and potent anticancer properties; however, the low solubility of nimesulide limits its applications. Drugs conjugated with hyaluronic acid (HA) are innovative carrier-mediated drug delivery systems characterized by CD44-mediated endocytosis of HA and intracellular drug release. In this study, hydrophobic nimesulide was conjugated to HA of two different molecular weights (360 kDa as HA with high molecular weight [HAH] and 43kDa as HA with low molecular weight [HAL]) to improve its tumor-targeting ability and hydrophilicity. Our results showed that hydrogenated nimesulide ( -[4-amino-2-phenoxyphenyl]methanesulfonamide) was successfully conjugated with both HA types by carbodiimide coupling and the degree of substitution of nimesulide was 1%, which was characterized by H nuclear magnetic resonance 400 MHz and total correlation spectroscopy. Both Alexa Fluor 647 labeled HAH and HAL could selectively accumulate in CD44-overexpressing HT-29 colorectal tumor area in vivo, as observed by in vivo imaging system. In the in vitro cytotoxic test, HA-nimesulide conjugate displayed >46% cell killing ability at a nimesulide concentration of 400 µM in HT-29 cells, whereas exiguous cytotoxic effects were observed on HCT-15 cells, indicating that HA-nimesulide causes cell death in CD44-overexpressing HT-29 cells. Regarding in vivo antitumor study, both HAL-nimesulide and HAH-nimesulide caused rapid tumor shrinkage within 3 days and successfully inhibited tumor growth, which reached 82.3% and 76.4% at day 24 through apoptotic mechanism in HT-29 xenografted mice, without noticeable morphologic differences in the liver or kidney, respectively. These results indicated that HA-nimesulide with improved selectivity through HA/CD44 receptor interactions has the potential to enhance the therapeutic efficacy and safety of nimesulide for cancer treatment.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Neoplasias Colorretais/tratamento farmacológico
Receptores de Hialuronatos/metabolismo
Ácido Hialurônico/química
Sulfonamidas/uso terapêutico
[Mh] Termos MeSH secundário: Adipatos/química
Animais
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Neoplasias Colorretais/patologia
Quebras de DNA de Cadeia Dupla
Sistemas de Liberação de Medicamentos
Feminino
Citometria de Fluxo
Fluoresceína-5-Isotiocianato/metabolismo
Células HT29
Seres Humanos
Marcação In Situ das Extremidades Cortadas
Camundongos Endogâmicos BALB C
Camundongos Nus
Peso Molecular
Espectroscopia de Prótons por Ressonância Magnética
Sulfonamidas/química
Sulfonamidas/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipates); 0 (Antineoplastic Agents); 0 (CD44 protein, human); 0 (Hyaluronan Receptors); 0 (Sulfonamides); 76A0JE0FKJ (adipic acid); 9004-61-9 (Hyaluronic Acid); I223NX31W9 (Fluorescein-5-isothiocyanate); V4TKW1454M (nimesulide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S120847


  3 / 1101 MEDLINE  
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[PMID]:28365404
[Au] Autor:Kruyer NS; Peralta-Yahya P
[Ad] Endereço:School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States; Renewable Bioproducts Institute, Georgia Institute of Technology, Atlanta, GA 30332, United States.
[Ti] Título:Metabolic engineering strategies to bio-adipic acid production.
[So] Source:Curr Opin Biotechnol;45:136-143, 2017 Jun.
[Is] ISSN:1879-0429
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adipic acid is the most industrially important dicarboxylic acid as it is a key monomer in the synthesis of nylon. Today, adipic acid is obtained via a chemical process that relies on petrochemical precursors and releases large quantities of greenhouse gases. In the last two years, significant progress has been made in engineering microbes for the production of adipic acid and its immediate precursors, muconic acid and glucaric acid. Not only have the microbial substrates expanded beyond glucose and glycerol to include lignin monomers and hemicellulose components, but the number of microbial chassis now goes further than Escherichia coli and Saccharomyces cerevisiae to include microbes proficient in aromatic degradation, cellulose secretion and degradation of multiple carbon sources. Here, we review the metabolic engineering and nascent protein engineering strategies undertaken in each of these chassis to convert different feedstocks to adipic, muconic and glucaric acid. We also highlight near term prospects and challenges for each of the metabolic routes discussed.
[Mh] Termos MeSH primário: Escherichia coli/metabolismo
Engenharia Metabólica
Saccharomyces cerevisiae/metabolismo
[Mh] Termos MeSH secundário: Adipatos/metabolismo
Ração Animal
Carbono/metabolismo
Ciclo do Ácido Cítrico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adipates); 7440-44-0 (Carbon); 76A0JE0FKJ (adipic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


  4 / 1101 MEDLINE  
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[PMID]:28237749
[Au] Autor:Yang X; Cai X; Yu A; Xi Y; Zhai G
[Ad] Endereço:Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
[Ti] Título:Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel.
[So] Source:J Colloid Interface Sci;496:311-326, 2017 06 15.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To remedy the problems riddled in cancer chemotherapy, such as poor solubility, low selectivity, and insufficient intra-cellular release of drugs, novel heparin-based redox-sensitive polymeric nanoparticles were developed. The amphiphilic polymer, heparin-alpha-tocopherol succinate (Hep-cys-TOS) was synthesized by grafting hydrophobic TOS to heparin using cystamine as the redox-sensitive linker, which could self-assemble into nanoparticles in phosphate buffer saline (PBS) with low critical aggregation concentration (CAC) values ranging from 0.026 to 0.093mg/mL. Paclitaxel (PTX)-loaded Hep-cys-TOS nanoparticles were prepared via a dialysis method, exhibiting a high drug-loading efficiency of 18.99%. Physicochemical properties of the optimized formulation were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM) and differential scanning calorimetry (DSC). Subsequently, the redox-sensitivity of Hep-cys-TOS nanoparticles was confirmed by the changes in size distribution, morphology and appearance after dithiothreitol (DTT) treatment. Besides, the in vitro release of PTX from Hep-cys-TOS nanoparticles also exhibited a redox-triggered profile. Also, the uptake behavior and pathways of coumarin 6-loaded Hep-cys-TOS nanoparticles were investigated, suggesting the nanoparticles could be taken into MCF-7 cells in energy-dependent, caveolae-mediated and cholesterol-dependent endocytosis manners. Later, MTT assays of different PTX-free and PTX-loaded formulations revealed the desirable safety of PTX-free nanoparticles and the enhanced anti-cancer activity of PTX-loaded Hep-cys-TOS nanoparticles (IC =0.79µg/mL). Apoptosis study indicated the redox-sensitive formulation could induce more apoptosis of MCF-7 cells than insensitive one (55.2% vs. 41.7%), showing the importance of intracellular burst release of PTX. Subsequently, the hemolytic toxicity confirmed the safety of the nanoparticles for intravenous administration. The results indicated the developed redox-sensitive nanoparticles were promising as intracellular drug delivery vehicles for cancer treatment.
[Mh] Termos MeSH primário: Antineoplásicos/química
Heparina/química
Nanopartículas/química
Paclitaxel/química
alfa-Tocoferol/química
[Mh] Termos MeSH secundário: Adipatos/química
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Química Farmacêutica
Sistemas de Liberação de Medicamentos
Liberação Controlada de Fármacos
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Oxirredução
Paclitaxel/farmacologia
Tamanho da Partícula
Polímeros/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adipates); 0 (Antineoplastic Agents); 0 (Polymers); 9005-49-6 (Heparin); H4N855PNZ1 (alpha-Tocopherol); P88XT4IS4D (Paclitaxel); VK98I9YW5M (adipic dihydrazide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE


  5 / 1101 MEDLINE  
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[PMID]:28208822
[Au] Autor:Falamarzpour P; Behzad T; Zamani A
[Ad] Endereço:Department of Chemical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran. p.falamarzpour@gmail.com.
[Ti] Título:Preparation of Nanocellulose Reinforced Chitosan Films, Cross-Linked by Adipic Acid.
[So] Source:Int J Mol Sci;18(2), 2017 Feb 13.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Adipic acid, an abundant and nontoxic compound, was used to dissolve and cross-link chitosan. After the preparation of chitosan films through casting technique, the in situ amidation reaction was performed at 80-100 °C as verified by Fourier transform infrared (FT-IR). The reaction was accompanied by the release of water which was employed to investigate the reaction kinetics. Accordingly, the reaction rate followed the first-order model and Arrhenius equation, and the activation energy was calculated to be 18 kJ/mol. Furthermore, the mechanical properties of the chitosan films were comprehensively studied. First, optimal curing conditions (84 °C, 93 min) were introduced through a central composite design. In order to evaluate the effects of adipic acid, the mechanical properties of physically cross-linked (uncured), chemically cross-linked (cured), and uncross-linked (prepared by acetic acid) films were compared. The use of adipic acid improved the tensile strength of uncured and chemically cross-linked films more than 60% and 113%, respectively. Finally, the effect of cellulose nanofibrils (CNFs) on the mechanical performance of cured films, in the presence of glycerol as a plasticizer, was investigated. The plasticized chitosan films reinforced by 5 wt % CNFs showed superior properties as a promising material for the development of chitosan-based biomaterials.
[Mh] Termos MeSH primário: Adipatos/química
Celulose/química
Quitosana/química
Reagentes para Ligações Cruzadas/química
Membranas Artificiais
Nanopartículas/química
[Mh] Termos MeSH secundário: Amidas/química
Cinética
Fenômenos Mecânicos
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipates); 0 (Amides); 0 (Cross-Linking Reagents); 0 (Membranes, Artificial); 76A0JE0FKJ (adipic acid); 9004-34-6 (Cellulose); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


  6 / 1101 MEDLINE  
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[PMID]:28143563
[Au] Autor:Karlsson E; Mapelli V; Olsson L
[Ad] Endereço:Department of Biology and Biological Engineering, Division of Industrial Biotechnology, Chalmers University of Technology, Gothenburg, Sweden.
[Ti] Título:Adipic acid tolerance screening for potential adipic acid production hosts.
[So] Source:Microb Cell Fact;16(1):20, 2017 Feb 01.
[Is] ISSN:1475-2859
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Biobased processes for the production of adipic acid are of great interest to replace the current environmentally detrimental petrochemical production route. No efficient natural producer of adipic acid has yet been identified, but several approaches for pathway engineering have been established. Research has demonstrated that the microbial production of adipic acid is possible, but the yields and titres achieved so far are inadequate for commercialisation. A plausible explanation may be intolerance to adipic acid. Therefore, in this study, selected microorganisms, including yeasts, filamentous fungi and bacteria, typically used in microbial cell factories were considered to evaluate their tolerance to adipic acid. RESULTS: Screening of yeasts and bacteria for tolerance to adipic acid was performed in microtitre plates, and in agar plates for A. niger in the presence of adipic acid over a broad range of concentration (0-684 mM). As the different dissociation state(s) of adipic acid may influence cells differently, cultivations were performed with at least two pH values. Yeasts and A. niger were found to tolerate substantially higher concentrations of adipic acid than bacteria, and were less affected by the undissociated form of adipic acid than bacteria. The yeast exhibiting the highest tolerance to adipic acid was Candida viswanathii, showing a reduction in maximum specific growth rate of no more than 10-15% at the highest concentration of adipic acid tested and the tolerance was not dependent on the dissociation state of the adipic acid. CONCLUSIONS: Tolerance to adipic acid was found to be substantially higher among yeasts and A. niger than bacteria. The explanation of the differences in adipic acid tolerance between the microorganisms investigated are likely related to fundamental differences in their physiology and metabolism. Among the yeasts investigated, C. viswanathii showed the highest tolerance and could be a potential host for a future microbial cell factory for adipic acid.
[Mh] Termos MeSH primário: Adipatos/metabolismo
Adipatos/farmacologia
Leveduras/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adipatos/química
Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Bactérias/metabolismo
Candida/efeitos dos fármacos
Candida/crescimento & desenvolvimento
Candida/metabolismo
Tolerância a Medicamentos
Fermentação
Ensaios de Triagem em Larga Escala
Concentração de Íons de Hidrogênio
Saccharomyces cerevisiae/efeitos dos fármacos
Saccharomyces cerevisiae/crescimento & desenvolvimento
Saccharomyces cerevisiae/metabolismo
Leveduras/crescimento & desenvolvimento
Leveduras/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipates); 76A0JE0FKJ (adipic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1186/s12934-017-0636-6


  7 / 1101 MEDLINE  
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[PMID]:28125209
[Au] Autor:Kascholke C; Loth T; Kohn-Polster C; Möller S; Bellstedt P; Schulz-Siegmund M; Schnabelrauch M; Hacker MC
[Ad] Endereço:Institute of Pharmacy, Pharmaceutical Technology, Leipzig University , Eilenburger Straße 15 a, 04317 Leipzig, Germany.
[Ti] Título:Dual-Functional Hydrazide-Reactive and Anhydride-Containing Oligomeric Hydrogel Building Blocks.
[So] Source:Biomacromolecules;18(3):683-694, 2017 Mar 13.
[Is] ISSN:1526-4602
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biomimetic hydrogels are advanced biomaterials that have been developed following different synthetic routes. Covalent postfabrication functionalization is a promising strategy to achieve efficient matrix modification decoupled of general material properties. To this end, dual-functional macromers were synthesized by free radical polymerization of maleic anhydride with diacetone acrylamide (N-(1,1-dimethyl-3-oxobutyl)acrylamide) and pentaerythritol diacrylate monostearate. Amphiphilic oligomers (M < 7.5 kDa) with anhydride contents of 7-20% offered cross-linking reactivity to yield rigid hydrogels with gelatinous peptides (E = 4-13 kPa) and good cell adhesion properties. Mildly reactive methyl ketones as second functionality remained intact during hydrogel formation and potential of covalent matrix modification was shown using hydrazide and hydrazine model compounds. Successful secondary dihydrazide cross-linking was demonstrated by an increase of hydrogel stiffness (>40%). Efficient hydrazide/hydrazine immobilization depending on solution pH, hydrogel ketone content as well as ligand concentration for bioconjugation was shown and reversibility of hydrazone formation was indicated by physiologically relevant hydrazide release over 7 days. Proof-of-concept experiments with hydrazido-functionalized hyaluronan demonstrated potential for covalent aECM immobilization. The presented dual-functional macromers have perspective as reactive hydrogel building blocks for various biomedical applications.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Hidrogéis/química
Anidridos Maleicos/química
[Mh] Termos MeSH secundário: Acrilamidas/química
Acrilatos/química
Adipatos/química
Adesão Celular
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Gelatina/química
Seres Humanos
Ácido Hialurônico/química
Concentração de Íons de Hidrogênio
Cetonas/química
Polietilenoglicóis/química
Polimerização
Estearatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylamides); 0 (Acrylates); 0 (Adipates); 0 (Biocompatible Materials); 0 (Hydrogels); 0 (Ketones); 0 (Maleic Anhydrides); 0 (N-(1,1-dimethyl-3-oxobutyl)acrylamide); 0 (Stearates); 0 (pentaerythritol diacrylate monostearate); 30IQX730WE (Polyethylene Glycols); 9000-70-8 (Gelatin); 9004-61-9 (Hyaluronic Acid); VK98I9YW5M (adipic dihydrazide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biomac.6b01355


  8 / 1101 MEDLINE  
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[PMID]:27933454
[Au] Autor:Kallscheuer N; Gätgens J; Lübcke M; Pietruszka J; Bott M; Polen T
[Ad] Endereço:IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülich GmbH, 52425, Jülich, Germany. n.kallscheuer@fz-juelich.de.
[Ti] Título:Improved production of adipate with Escherichia coli by reversal of ß-oxidation.
[So] Source:Appl Microbiol Biotechnol;101(6):2371-2382, 2017 Mar.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The linear C dicarboxylic acid adipic acid is an important bulk chemical in the petrochemical industry as precursor of the polymer nylon-6,6-polyamide. In recent years, efforts were made towards the biotechnological production of adipate from renewable carbon sources using microbial cells. One strategy is to produce adipate via a reversed ß-oxidation pathway. Hitherto, the adipate titers were very low due to limiting enzyme activities for this pathway. In most cases, the CoA intermediates are non-natural substrates for the tested enzymes and were therefore barely converted. We here tested heterologous enzymes in Escherichia coli to overcome these limitations and to improve the production of adipate via a reverse ß-oxidation pathway. We tested in vitro selected enzymes for the efficient reduction of the enoyl-CoA and in the final reaction for the thioester cleavage. The genes encoding the enzymes which showed in vitro the highest activity were then used to construct an expression plasmid for a synthetic adipate pathway. Expression of paaJ, paaH, paaF, dcaA, and tesB in E. coli BL21(DE3) resulted in the production of up to 36 mg/L of adipate after 30 h of cultivation. Beside the activities of the pathway enzymes, the availability of metabolic precursors may limit the synthesis of adipate, providing another key target for further strain engineering towards high-yield production of adipate with E. coli.
[Mh] Termos MeSH primário: Acetil-CoA C-Aciltransferase/metabolismo
Adipatos/metabolismo
Enoil-CoA Hidratase/metabolismo
Proteínas de Escherichia coli/metabolismo
Escherichia coli/metabolismo
Regulação Bacteriana da Expressão Gênica
Oxirredutases/metabolismo
[Mh] Termos MeSH secundário: Acetil-CoA C-Aciltransferase/genética
Enoil-CoA Hidratase/genética
Escherichia coli/genética
Proteínas de Escherichia coli/genética
Engenharia Metabólica
Redes e Vias Metabólicas/genética
Oxirredução
Oxirredutases/genética
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipates); 0 (Escherichia coli Proteins); 0 (Recombinant Proteins); 76A0JE0FKJ (adipic acid); EC 1.- (Oxidoreductases); EC 2.3.1.16 (Acetyl-CoA C-Acyltransferase); EC 2.3.1.174 (3-oxoadipyl-coenzyme A thiolase); EC 4.2.1.17 (Enoyl-CoA Hydratase); EC 4.2.1.17 (PaaF protein, E coli)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-016-8033-3


  9 / 1101 MEDLINE  
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[PMID]:27907880
[Au] Autor:Kumar M; Ladyman MK; Mai N; Temple T; Coulon F
[Ad] Endereço:Centre for Defence Chemistry, Cranfield University, Defence Academy of the United Kingdom, Shrivenham, SN6 7LA, UK.
[Ti] Título:Release of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) from polymer-bonded explosives (PBXN-109) into water by artificial weathering.
[So] Source:Chemosphere;169:604-608, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polymer-bonded explosives (PBX) fulfil the need for insensitive munitions. However, the environmental impacts of PBX are unclear, even though it is likely that PBX residues from low-order detonations and unexploded ordnance are deposited on military training ranges. The release of high explosives from the polymer matrix into the environment has not been studied in detail, although as polymers degrade slowly in the environment we anticipate high explosives to be released into the environment. In this study, PBXN-109 (nominally 64% RDX) samples were exposed to variable UK climatic conditions reproduced in the laboratory to determine the effects of temperature, UV irradiation and rainfall on the release of RDX from the polymer binder. The most extreme conditions for spring, summer and winter in the UK were artificially reproduced. We found that up to 0.03% of RDX was consistently released from PBXN-109. The rate of RDX release was highest in samples exposed to the summer simulation, which had the lowest rainfall, but the highest temperatures and longest UV exposure. This was confirmed by additional experiments simulating an extreme summer month with consistently high temperatures and long periods of sunlight. These results probably reflect the combination of polymer swelling and degradation when samples are exposed to higher temperatures and prolonged UV irradiation.
[Mh] Termos MeSH primário: Substâncias Explosivas/química
Polímeros/química
Triazinas/análise
Poluentes Químicos da Água/análise
Tempo (Meteorologia)
[Mh] Termos MeSH secundário: Adipatos/química
Butadienos/química
Elastômeros/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,3,5-trinitroperhydro-1,3,5-triazine); 0 (Adipates); 0 (Butadienes); 0 (Elastomers); 0 (Explosive Agents); 0 (Polymers); 0 (Triazines); 0 (Water Pollutants, Chemical); 2BD76YG9SI (dioctyl adipate); 9003-17-2 (polybutadiene); W91SSV5831 (cyclonite)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


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[PMID]:27723700
[Au] Autor:Belik BM
[Ad] Endereço:Department of General Surgery, Rostov State Medical University, Health Ministry of Russia, Rostov-on-Don, Russia.
[Ti] Título:[Evaluation of clinical efficacy of serotonin adipate in treatment and prevention of enteral insufficiency syndrome at generalized peritonitis].
[Ti] Título:Otsenka klinicheskoi effektivnosti preparata serotonina adipinat v lechenii i profilaktike sindroma enteral'noi nedostatochnosti pri rasprostranennom peritonite..
[So] Source:Khirurgiia (Mosk);(9):76-82, 2016.
[Is] ISSN:0023-1207
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To substantiate pathogenetic expediency and to evaluate the clinical efficacy of the drug use serotonin adipate (dinaton) in a complex correction enteral insufficiency syndrome (EIN) in patients with generalized peritonitis (GP). MATERIAL AND METHODS: The comparative analysis of results of treatment of 182 patients with GP, which in principle approach to EIN correction in the postoperative period were divided into two groups. Group I consisted of 92 patients who received standard intensive therapy using conventional methods of stimulation of intestinal peristalsis. Group II consisted of 90 patients on a background of standard treatment was carried further pharmacological stimulation of intestinal motility drug serotonin adipate (dinaton). The research program included an assessment of clinical parameters intestinal motility recovery, evaluation of the severity of the patients on a scale of APACHE II, determining the blood levels of serotonin and the level of the main biomarkers of systemic inflammatory response (SIR), the study of blood flow in the vessels of splanchnic bed, the measurement of intra-abdominal pressure with the calculation of intraperitoneal perfusion pressure. RESULTS: It is found that the development and progression of abdominal inflammation is accompanied by a sharp decrease in blood serotonin level is in phase III GP decreases 4.7 times compared to the control value. It is shown that using of serotonin adipate (dinaton) in treatment of patients with GP promotes early recovery of intestinal motility and the resolution of EIN, the elimination of intra-abdominal hypertension and disorders of splanchnic blood flow, as well as the rapid regression of the manifestations of the SIR and endotoxemia. Postoperative mortality in group I patients was 28.3% in group II - 20.0%. CONCLUSION: The inclusion of serotonin adipate (dinaton) in the complex corrective therapy standard in the postoperative period in GP patients is pathogenetically justified, as it promotes early restoration of motor activity of the gastrointestinal tract, the elimination of intestinal paresis and resolution of EIN, which leads to an improvement of results of surgical treatment of this patients.
[Mh] Termos MeSH primário: Adipatos/administração & dosagem
Motilidade Gastrointestinal/efeitos dos fármacos
Peritonite
Complicações Pós-Operatórias
Serotonina/análogos & derivados
Serotonina/sangue
Procedimentos Cirúrgicos Operatórios/efeitos adversos
[Mh] Termos MeSH secundário: APACHE
Cavidade Abdominal/cirurgia
Adulto
Idoso
Feminino
Fármacos Gastrointestinais/administração & dosagem
Seres Humanos
Hipertensão Intra-Abdominal/diagnóstico
Hipertensão Intra-Abdominal/etiologia
Hipertensão Intra-Abdominal/prevenção & controle
Masculino
Meia-Idade
Peritonite/sangue
Peritonite/diagnóstico
Peritonite/tratamento farmacológico
Peritonite/fisiopatologia
Complicações Pós-Operatórias/sangue
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/prevenção & controle
Serotonina/administração & dosagem
Procedimentos Cirúrgicos Operatórios/métodos
Síndrome de Resposta Inflamatória Sistêmica/diagnóstico
Síndrome de Resposta Inflamatória Sistêmica/etiologia
Síndrome de Resposta Inflamatória Sistêmica/prevenção & controle
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipates); 0 (Gastrointestinal Agents); 16031-83-7 (serotonin adipinate); 333DO1RDJY (Serotonin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE
[do] DOI:10.17116/hirurgia2016976-82



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