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[PMID]:24261485
[Au] Autor:Hai Y; Dugery RJ; Healy D; Christianson DW
[Ad] Endereço:Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , Philadelphia, PA 19104-6323, U.S.A.
[Ti] Título:Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme.
[So] Source:Biochemistry;52(51):9294-309, 2013 Dec 23.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The crystal structure of formiminoglutamase from Trypanosoma cruzi (TcFIGase) is reported at 1.85 Å resolution. Although the structure of this enzyme was previously determined by the Structural Genomics of Pathogenic Protozoa Consortium (PDB accession code 2A0M), this structure was determined at low pH and lacked bound metal ions; accordingly, the protein was simply annotated as "arginase superfamily protein" with undetermined function. We show that reconstitution of this protein with Mn²âº confers maximal catalytic activity in the hydrolysis of formiminoglutamate to yield glutamate and formamide, thereby demonstrating that this protein is a metal-dependent formiminoglutamase. Equilibration of TcFIGase crystals with MnCl2 at higher pH yields a binuclear manganese cluster similar to that observed in arginase, except that the histidine ligand to the Mn²âº(A) ion of arginase is an asparagine ligand (N114) to the Mn²âº(A) ion of TcFIGase. The crystal structure of N114H TcFIGase reveals a binuclear manganese cluster essentially identical to that of arginase, but the mutant exhibits a modest 35% loss of catalytic efficiency (k(cat)/K(M)). Interestingly, when TcFIGase is prepared and crystallized in the absence of reducing agents at low pH, a disulfide linkage forms between C35 and C242 in the active site. When reconstituted with Mn²âº at higher pH, this oxidized enzyme exhibits a modest 33% loss of catalytic efficiency. Structure determinations of the metal-free and metal-bound forms of oxidized TcFIGase reveal that although disulfide formation constricts the main entrance to the active site, other structural changes open alternative channels to the active site that may help sustain catalytic activity.
[Mh] Termos MeSH primário: Ácido Formiminoglutâmico/metabolismo
Hidrolases/química
Metaloproteínas/química
Modelos Moleculares
Proteínas de Protozoários/química
Trypanosoma cruzi/enzimologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Substituição de Aminoácidos
Apoenzimas/química
Apoenzimas/genética
Apoenzimas/metabolismo
Arginase/química
Arginase/metabolismo
Asparagina/química
Sítios de Ligação
Sequência Conservada
Cisteína/química
Hidrolases/genética
Hidrolases/metabolismo
Manganês/análise
Manganês/química
Manganês/metabolismo
Metaloproteínas/genética
Metaloproteínas/metabolismo
Dados de Sequência Molecular
Proteínas Mutantes/química
Proteínas Mutantes/metabolismo
Conformação Proteica
Proteínas de Protozoários/genética
Proteínas de Protozoários/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Apoenzymes); 0 (Metalloproteins); 0 (Mutant Proteins); 0 (Protozoan Proteins); 0 (Recombinant Proteins); 42Z2K6ZL8P (Manganese); 7006-34-0 (Asparagine); 816-90-0 (Formiminoglutamic Acid); EC 3.- (Hydrolases); EC 3.5.3.1 (Arginase); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131123
[St] Status:MEDLINE
[do] DOI:10.1021/bi401352h


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[PMID]:22225844
[Au] Autor:Gerth ML; Ferla MP; Rainey PB
[Ad] Endereço:New Zealand Institute for Advanced Study, Massey University, Auckland, New Zealand. m.l.gerth@massey.ac.nz
[Ti] Título:The origin and ecological significance of multiple branches for histidine utilization in Pseudomonas aeruginosa PAO1.
[So] Source:Environ Microbiol;14(8):1929-40, 2012 Aug.
[Is] ISSN:1462-2920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pseudomonas proliferate in a wide spectrum of harsh and variable environments. In many of these environments, amino acids, such as histidine, are a valuable source of carbon, nitrogen and energy. Here, we demonstrate that the histidine uptake and utilization (hut) pathway of Pseudomonas aeruginosa PAO1 contains two branches from the intermediate formiminoglutamate to the product glutamate. Genetic analysis revealed that the four-step route is dispensable as long as the five-step route is present (and vice versa). Mutants with deletions of either the four-step (HutE) or five-step (HutFG) branches were competed against each other and the wild-type strain to test the hypothesis of ecological redundancy; that is, that the presence of two pathways confers no benefit beyond that delivered by the individual pathways. Fitness assays performed under several environmental conditions led us to reject this hypothesis; the four-step pathway can provide an advantage when histidine is the sole carbon source. An IclR-type regulator (HutR) was identified that regulates the four-step pathway. Comparison of sequenced genomes revealed that P.aeruginosa strains and P.fluorescens Pf-5 have branched hut pathways. Phylogenetic analyses suggests that the gene encoding formiminoglutamase (hutE) was acquired by horizontal gene transfer from a Ralstonia-like ancestor. Potential barriers to inter-species transfer of the hutRE module were explored by transferring it from P.aeruginosa PAO1 to P.fluorescens SBW25. Transfer of the operon conferred the ability to utilize histidine via the four-step pathway in a single step, but the fitness cost of acquiring this new operon was found to be environment dependent.
[Mh] Termos MeSH primário: Meio Ambiente
Histidina/metabolismo
Pseudomonas aeruginosa/metabolismo
[Mh] Termos MeSH secundário: Ácido Formiminoglutâmico/metabolismo
Regulação Bacteriana da Expressão Gênica
Genoma Bacteriano/genética
Ácido Glutâmico/biossíntese
Mutação
Óperon/genética
Filogenia
Pseudomonas aeruginosa/classificação
Pseudomonas aeruginosa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3KX376GY7L (Glutamic Acid); 4QD397987E (Histidine); 816-90-0 (Formiminoglutamic Acid)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120110
[St] Status:MEDLINE
[do] DOI:10.1111/j.1462-2920.2011.02691.x


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[PMID]:17118722
[Au] Autor:Bishop MJ; Crow BS; Kovalcik KD; George J; Bralley JA
[Ad] Endereço:Metametrix Clinical Laboratory, 4855 Peachtree Ind. Blvd. Norcross, GA 30092, USA. mbishop@metametrix.com
[Ti] Título:Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;848(2):303-10, 2007 Apr 01.
[Is] ISSN:1570-0232
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A rapid and accurate quantitative method was developed and validated for the analysis of four urinary organic acids with nitrogen containing functional groups, formiminoglutamic acid (FIGLU), pyroglutamic acid (PYRGLU), 5-hydroxyindoleacetic acid (5-HIAA), and 2-methylhippuric acid (2-METHIP) by liquid chromatography tandem mass spectrometry (LC/MS/MS). The chromatography was developed using a weak anion-exchange amino column that provided mixed-mode retention of the analytes. The elution gradient relied on changes in mobile phase pH over a concave gradient, without the use of counter-ions or concentrated salt buffers. A simple sample preparation was used, only requiring the dilution of urine prior to instrumental analysis. The method was validated based on linearity (r2>or=0.995), accuracy (85-115%), precision (C.V.<12%), sample preparation stability (
[Mh] Termos MeSH primário: Ácidos/urina
Cromatografia por Troca Iônica/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Ácidos/química
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Resinas de Troca de Ânions
Ácido Formiminoglutâmico/química
Ácido Formiminoglutâmico/urina
Hipuratos/química
Hipuratos/urina
Seres Humanos
Meia-Idade
Estrutura Molecular
Compostos Orgânicos/química
Compostos Orgânicos/urina
Ácido Pirrolidonocarboxílico/química
Ácido Pirrolidonocarboxílico/urina
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids); 0 (Anion Exchange Resins); 0 (Hippurates); 0 (Organic Chemicals); 42013-20-7 (2-methylhippuric acid); 816-90-0 (Formiminoglutamic Acid); SZB83O1W42 (Pyrrolidonecarboxylic Acid)
[Em] Mês de entrada:0706
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061123
[St] Status:MEDLINE


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[PMID]:16766145
[Au] Autor:Rajamani R; Muthuvel A; Senthilvelan M; Sheeladevi R
[Ad] Endereço:Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Taramani, Chennai, India.
[Ti] Título:Oxidative stress induced by methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve.
[So] Source:Toxicol Lett;165(3):265-73, 2006 Sep 10.
[Is] ISSN:0378-4274
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The vulnerability of the nervous system due to methanol (MeOH) intoxication is a well known fact and reports on the production of free radicals due to MeOH exposure and their involvement in excitotoxicity and neuronal apoptosis are being increasingly reported. We report on MeOH induced free radical changes and oxidative damages to proteins in the discrete regions of rat brain, retina and optic nerve. The present study used rats administered with methotrexate (MTX) to induce folate deficiency. Three groups of animals, namely saline control, MTX control, MTX-MeOH group were tested. The rats were injected intraperitoneally with MeOH (3 g/kg). After 24 h of MeOH administration, the levels of free radical scavengers, superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione levels were estimated in the six discrete regions of brain (cerebral cortex, cerebellum, midbrain, pons medulla, hippocampus and hypothalamus), retina and optic nerve specimens. The levels of protein thiol, protein carbonyl and lipid peroxidation were also estimated and the expression of HSP70 in the hippocampus was analyzed by Western blot. Marked reduction in the levels of glutathione in the MTX-MeOH group in relation to MTX control was observed and found to be increased in MTX control in relation to saline control. Increased protein carbonyls and decreased protein thiols were documented in all the specimens tested. In addition, marked expression of HSP70 was observed in the hippocampus. The present investigation suggest that MeOH exposure results in increased generation of free radicals and significant protein oxidative damage and attempts to study the underlying mechanisms involved might reveal more insights to our existing knowledge on MeOH intoxication and related areas.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Metanol/toxicidade
Metotrexato/toxicidade
Nervo Óptico/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Retina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Catalase/metabolismo
Quimioterapia Combinada
Formiatos/sangue
Ácido Formiminoglutâmico/metabolismo
Regulação da Expressão Gênica
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Proteínas de Choque Térmico HSP70/metabolismo
Peroxidação de Lipídeos
Masculino
Metanol/sangue
Ratos
Ratos Wistar
Compostos de Sulfidrila/sangue
Superóxido Dismutase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Formates); 0 (HSP70 Heat-Shock Proteins); 0 (Sulfhydryl Compounds); 0YIW783RG1 (formic acid); 816-90-0 (Formiminoglutamic Acid); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); Y4S76JWI15 (Methanol); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:0609
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060613
[St] Status:MEDLINE


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[PMID]:16354994
[Au] Autor:Baggot PJ; Eliseo AJ; Kalamarides JA; Shoemaker JD
[Ad] Endereço:Queen of Angels Hospital, Los Angeles, CA, USA. pjbaggot@hotmail.com
[Ti] Título:A folate-dependent metabolite in amniotic fluid from pregnancies with normal or trisomy 21 chromosomes.
[So] Source:Fetal Diagn Ther;21(1):148-52, 2006.
[Is] ISSN:1015-3837
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Previous studies have given conflicting results as to whether or not folate metabolism is altered in Down syndrome. Folate is necessary to facilitate metabolism of one-carbon units. Folate accepts one-carbon units from one-carbon unit donors, including formiminoglutamate (FIGLU). Folate deficiency leads to accumulation of FIGLU and impairment of one-carbon unit metabolism. FIGLU is a functional measure of folate deficiency. MATERIALS AND METHODS: Archived anonymized amniotic fluid specimens were obtained from normal pregnancies and those with Down syndrome. Gas liquid chromatography/mass spectrometry was used to quantitate FIGLU, which is elevated in folate deficiency. A tetra-deuterated FIGLU was used as a standard, and single-ion monitoring was performed. Nonparametric statistical analysis was performed with the Mann-Whitney U test. RESULTS: FIGLU was significantly lower in pregnancies with Down syndrome. The median FIGLU level was 0.9 micromol/l in amniotic fluid from fetuses with Down syndrome. The median FIGLU level was 1.3 in amniotic fluid from control fetuses. This difference was statistically significant (p = 0.009). No statistically significant differences were found with histidine or glutamate. DISCUSSION: There was no evidence of folate deficiency. FIGLU was decreased, not increased. Decreased FIGLU might result from accelerated activity of one or more genes on chromosome 21, by a gene dosage effect. Genes which might explain the reduced FIGLU include one which degrades FIGLU (glutamate formiminotransferase-cyclodeaminase), one which participates in purine synthesis, and one which degrades homocysteine (cystathionine-beta-synthase).
[Mh] Termos MeSH primário: Líquido Amniótico/metabolismo
Síndrome de Down/metabolismo
Ácido Formiminoglutâmico/metabolismo
[Mh] Termos MeSH secundário: Amniocentese
Síndrome de Down/diagnóstico
Feminino
Ácido Fólico/metabolismo
Seres Humanos
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
816-90-0 (Formiminoglutamic Acid); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:0601
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051216
[St] Status:MEDLINE


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[PMID]:9868217
[Au] Autor:Yu S; Morris JG
[Ad] Endereço:Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
[Ti] Título:Folate requirement of growing kittens to prevent elevated formiminoglutamic acid excretion following histidine loading.
[So] Source:J Nutr;128(12 Suppl):2606S-2608S, 1998 Dec.
[Is] ISSN:0022-3166
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Gatos/crescimento & desenvolvimento
Dieta
Ácido Fólico/administração & dosagem
Ácido Formiminoglutâmico/urina
Histidina/administração & dosagem
Necessidades Nutricionais
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/diagnóstico
Doenças do Gato/urina
Gatos/fisiologia
Ingestão de Alimentos
Índices de Eritrócitos
Feminino
Ácido Fólico/sangue
Deficiência de Ácido Fólico/diagnóstico
Deficiência de Ácido Fólico/urina
Deficiência de Ácido Fólico/veterinária
Masculino
Ganho de Peso
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
4QD397987E (Histidine); 816-90-0 (Formiminoglutamic Acid); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:9901
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:981230
[St] Status:MEDLINE


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[PMID]:9645043
[Au] Autor:Narisawa K
[Ad] Endereço:Department of Medical Genetics (Biochemical Genetics), Tohoku University School of Medicine.
[Ti] Título:[Glutamate-formiminotransferase deficiency].
[So] Source:Ryoikibetsu Shokogun Shirizu;(19 Pt 2):204-6, 1998.
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Hidroximetil e Formil Transferases/deficiência
[Mh] Termos MeSH secundário: Biomarcadores/urina
Teste de FIGLU
Ácido Fólico/administração & dosagem
Ácido Formiminoglutâmico/urina
Glutamato Formimidoiltransferase
Seres Humanos
Piridoxina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 816-90-0 (Formiminoglutamic Acid); 935E97BOY8 (Folic Acid); EC 2.1.2.- (Hydroxymethyl and Formyl Transferases); EC 2.1.2.5 (Glutamate Formimidoyltransferase); KV2JZ1BI6Z (Pyridoxine)
[Em] Mês de entrada:9809
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980630
[St] Status:MEDLINE


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[PMID]:9381269
[Au] Autor:Marín GH; Tentoni J; Cicchetti G
[Ad] Endereço:Servicio de Hematología, Hospital Interzonal Gral de Agudos San Martin, La Plata, Argentina.
[Ti] Título:[Megaloblastic anemia: rapid and economical study].
[Ti] Título:Anemia megaloblástica: su estudio en forma rápida y económica..
[So] Source:Sangre (Barc);42(3):235-8, 1997 Jun.
[Is] ISSN:0036-4355
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:The diagnosis of megaloblastic anaemias caused by cobalamine or folate deficiency are still difficult. The dosage of these two substances help to differenciate between both carencies, but it is not determinant of any of them and is an expensive method. Homocisteinuria (HC), methylmalonuria (MMA) and formiminoglutamic acid (FIGLU) are cheap tests which could help in the differential diagnosis, if they are used properly. We report 62 patients to whom we made these test simultaneously. All of the patients received 10 micrograms of vit B12 and after 72 hours, 1 mg/day of folic acid (for 3 days). In both cases waiting for the increase of reticulocytyes up to 150 x 10(9)/L as a form of therapeutic test of diagnosis. By this simple way we have detected 97.9% of specificity for cobalamin deficiency of the MMA test, and only 4.2% for HC. This last test had increased its specificity up to 91.6% in association with the negative FIGLU test. We have also found a high specificity (92.3%) for FIGLU due to the detection of folate deficiency, in opposition with other authors who had described it as low as 50%. We have also compared the costs of the 3 tests with the dosage of cobalamine and folate, and we have found that the formers are 11 times less expensive than the last ones.
[Mh] Termos MeSH primário: Anemia Megaloblástica/etiologia
Deficiência de Ácido Fólico/diagnóstico
Ácido Formiminoglutâmico/urina
Homocisteína/urina
Ácido Metilmalônico/urina
Deficiência de Vitamina B 12/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Algoritmos
Anemia Megaloblástica/sangue
Anemia Megaloblástica/economia
Anemia Megaloblástica/urina
Controle de Custos
Diagnóstico Diferencial
Testes Diagnósticos de Rotina/economia
Feminino
Ácido Fólico
Deficiência de Ácido Fólico/sangue
Deficiência de Ácido Fólico/complicações
Deficiência de Ácido Fólico/urina
Histidina
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Gravidez
Complicações Hematológicas na Gravidez/sangue
Complicações Hematológicas na Gravidez/diagnóstico
Contagem de Reticulócitos/efeitos dos fármacos
Estudos Retrospectivos
Sensibilidade e Especificidade
Fatores de Tempo
Urinálise/economia
Vitamina B 12/sangue
Vitamina B 12/farmacologia
Deficiência de Vitamina B 12/sangue
Deficiência de Vitamina B 12/complicações
Deficiência de Vitamina B 12/urina
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0LVT1QZ0BA (Homocysteine); 4QD397987E (Histidine); 816-90-0 (Formiminoglutamic Acid); 8LL8S712J7 (Methylmalonic Acid); 935E97BOY8 (Folic Acid); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:9710
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970601
[St] Status:MEDLINE


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[PMID]:9363317
[Au] Autor:Uthus EO; Poellot RA
[Ad] Endereço:United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202-9034, USA.
[Ti] Título:Dietary nickel and folic acid interact to affect folate and methionine metabolism in the rat.
[So] Source:Biol Trace Elem Res;58(1-2):25-33, 1997 Jul-Aug.
[Is] ISSN:0163-4984
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A previous experiment using rats indicated that dietary nickel (Ni), folic acid, and their interaction affected variables associated with one-carbon metabolism. That study used diets that produced only mild folate deficiency. Thus, an experiment was performed to determine the effect of a severe folate deficiency on nickel deprivation in rats. A 2 x 2 factorially arranged experiment used groups of six weanling Sprague-Dawley rats. Dietary variables were nickel, as NiCl2-6H2O, 0 or 1 microgram/g and folic acid, 0 or 4 mg/kg. All diets contained 10 g succinylsulfathiazole/kg to suppress microbial folate synthesis. The basal diet contained < 20 ng Ni/g. After 58 d, an interaction between nickel and folate affected the urinary excretion of formiminoglutamic acid (FIGLU) and the liver concentration of S-adenosylmethionine (SAM). Because of this, it is proposed that the physiological function of nickel is related to the common metabolism shared by SAM and FIGLU. Possibly the physiological function of nickel could be related to the tissue concentration of 5-methyltetrahydrofolate (MTHF) or tetrahydrofolate (THF).
[Mh] Termos MeSH primário: Deficiência de Ácido Fólico/metabolismo
Metionina/metabolismo
Níquel/metabolismo
[Mh] Termos MeSH secundário: Animais
Ácido Fólico/farmacologia
Ácido Formiminoglutâmico/metabolismo
Fígado/metabolismo
Masculino
Níquel/farmacologia
Ratos
Ratos Sprague-Dawley
S-Adenosil-Homocisteína/metabolismo
S-Adenosilmetionina/metabolismo
Sulfatiazóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfathiazoles); 7LP2MPO46S (S-Adenosylmethionine); 7OV03QG267 (Nickel); 816-90-0 (Formiminoglutamic Acid); 935E97BOY8 (Folic Acid); 979-92-0 (S-Adenosylhomocysteine); AE28F7PNPL (Methionine); RSS8647O4S (succinylsulfathiazole)
[Em] Mês de entrada:9801
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970701
[St] Status:MEDLINE


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Fotocópia
[PMID]:8753488
[Au] Autor:Owada M
[Ad] Endereço:Department of Pediatrics, Nihon University School of Medicine.
[Ti] Título:[Formiminoglutamic acid (FIGLU)].
[So] Source:Nihon Rinsho;53 Su Pt 1:518-22, 1995 Feb.
[Is] ISSN:0047-1852
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Ácido Formiminoglutâmico/urina
[Mh] Termos MeSH secundário: Ácido Formiminoglutâmico/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
816-90-0 (Formiminoglutamic Acid)
[Em] Mês de entrada:9610
[Cu] Atualização por classe:110727
[Lr] Data última revisão:
110727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950201
[St] Status:MEDLINE



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