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  1 / 5709 MEDLINE  
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[PMID]:28886192
[Au] Autor:Deng T; Mai Z; Cai C; Duan X; Zhu W; Zhang T; Wu W; Zeng G
[Ad] Endereço:Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
[Ti] Título:Influence of weight status on 24-hour urine composition in adults without urolithiasis: A nationwide study based on a Chinese Han population.
[So] Source:PLoS One;12(9):e0184655, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study sought to explore the influence of different body weight statuses on 24-hour urine compositions in adults without urolithiasis based on a nationwide study of a Chinese Han population. MATERIAL AND METHODS: Twenty-four-hour urine samples from 584 Chinese Han adults without urolithiasis in six cities were analyzed. The participants were divided into four body weight status types according to their body mass indices (BMIs) according to WHO guidelines. The baseline characteristics and 24-hour urine compositions of the standard weight group were compared with those of the underweight, overweight and obese groups. The influences of different body weight statuses on the 24-hour urine compositions were explored using univariate and multivariate logistic regressions. RESULTS: The numbers of participants in the underweight, standard weight, overweight and obese status groups were 24, 376, 149 and 35, respectively. The overweight and obese groups suffered significantly higher risks of hypertension and diabetes mellitus than the standard weight group. In the univariate analyses, compared with the standard weight group, the overweight group had significantly higher levels of urine citrate (mean difference [MD] = 0.51 mmol, 95% confidence interval [CI]: 0.15-0.87, P = 0.001), potassium (MD = 6.63 mmol, 95% CI: 1.13-12.14, P = 0.01) and magnesium (MD = 0.38 mmol, 95% CI: 0.08-0.69, P = 0.014). Significant increases in urine citrate (MD = 0.85 mmol, 95% CI: 0.01-1.68, P = 0.046), magnesium (MD = 0.69 mmol, 95% CI: 0.13-1.25, P = 0.016) and phosphate (MD = 2.28 mmol, 95% CI: 0.03-4.54, P = 0.047) were found in the obese group. No significant differences were detected between the standard weight and underweight groups. In the multivariate logistic regression analyses, we only observed significantly higher levels of urine potassium (odds ratio [OR] = 1.02, 95% CI: 1.00-1.04, P = 0.03) in the overweight group and phosphate (OR = 1.32, 95% CI: 1.05-1.66, P = 0.018) in the obese group when compared with the standard weight group. CONCLUSIONS: Nonstone-forming adults with overweight or obese statuses were at higher risks of hypertension and diabetes mellitus. Obese nonstone-formers might have a greater risk of urinary stone formation due to increased urinary phosphate excretion. Additionally, underweight status had no influence on 24-hour urine composition.
[Mh] Termos MeSH primário: Peso Corporal/fisiologia
Obesidade/urina
Sobrepeso/urina
Urolitíase/urina
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Cálcio/urina
China
Ácido Cítrico/urina
Seres Humanos
Resistência à Insulina/fisiologia
Modelos Logísticos
Meia-Idade
Análise Multivariada
Oxalatos/urina
Sódio/urina
Ácido Úrico/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); 268B43MJ25 (Uric Acid); 2968PHW8QP (Citric Acid); 9NEZ333N27 (Sodium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184655


  2 / 5709 MEDLINE  
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[PMID]:28658741
[Au] Autor:Graça CAL; Correia de Velosa A; Teixeira ACSC
[Ad] Endereço:Universidade de São Paulo, Avenida Prof. Luciano Gualberto, tr. 3, 380, São Paulo, Brazil. Electronic address: catia.graca@usp.br.
[Ti] Título:Role of Fe(III)-carboxylates in AMZ photodegradation: A response surface study based on a Doehlert experimental design.
[So] Source:Chemosphere;184:981-991, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Photochemical redox reactions of Fe(III) complexes in surface waters are important sources of radical species, therefore contributing to the sunlight-driven elimination of waterborne recalcitrant contaminants. In this study, the effects of three Fe(III)-carboxylates (i.e., oxalate, citrate, and tartrate) on the UVA photoinduced oxidation of the herbicide amicarbazone (AMZ) were investigated. A Doehlert experimental design was applied to find the Fe(III):ligand ratios and pH that achieved the fastest AMZ degradation rate. The results indicated optimal ratios of 1:10 (Fe(III):oxalate), 1:4 (Fe(III):citrate), and 1:1 (Fe(III):tartrate), with the [Fe(III)] set at 0.1 mmol L and the best pH found to be 3.5 for all the complexes. In addition, a statistical model that predicts the observed degradation rate constant (k ) as a function of pH and Fe(III):carboxylate ratio was obtained for each complex, enabling AMZ-photodegradation predictions based on these two variables. To the best of our knowledge, this is the first time that such models are proposed. Not only the pH-dependent speciation of Fe(III) in solution but also the time profiles of photogenerated OH, Fe(II), and H O gave appropriate support to the experimental results. Additional experiments using a sampled sewage treatment plant effluent suggest that the addition of aqua and/or Fe(III)-oxalate complexes to the matrix may also be effective for AMZ removal from natural waters in case their natural occurrence is not high enough to promote pollutant degradation. Therefore, the inclusion of Fe(III)-complexes in investigations dealing with the environmental fate of emerging pollutants in natural waterbodies is strongly recommended.
[Mh] Termos MeSH primário: Compostos Férricos/química
Modelos Químicos
Fotólise
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Ácidos Carboxílicos
Citratos
Ácido Cítrico/química
Peróxido de Hidrogênio/química
Oxalatos/química
Oxirredução
Projetos de Pesquisa
Luz Solar
Água/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Citrates); 0 (Ferric Compounds); 0 (Oxalates); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 2968PHW8QP (Citric Acid); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE


  3 / 5709 MEDLINE  
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[PMID]:28514140
[Au] Autor:Pierce E; Mansoorabadi SO; Can M; Reed GH; Ragsdale SW
[Ad] Endereço:Department of Biological Chemistry, University of Michigan , Ann Arbor, Michigan 48109-0606, United States.
[Ti] Título:Properties of Intermediates in the Catalytic Cycle of Oxalate Oxidoreductase and Its Suicide Inactivation by Pyruvate.
[So] Source:Biochemistry;56(22):2824-2835, 2017 Jun 06.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxalate:ferredoxin oxidoreductase (OOR) is an unusual member of the thiamine pyrophosphate (TPP)-dependent 2-oxoacid:ferredoxin oxidoreductase (OFOR) family in that it catalyzes the coenzyme A (CoA)-independent conversion of oxalate into 2 equivalents of carbon dioxide. This reaction is surprising because binding of CoA to the acyl-TPP intermediate of other OFORs results in formation of a CoA ester, and in the case of pyruvate:ferredoxin oxidoreductase (PFOR), CoA binding generates the central metabolic intermediate acetyl-CoA and promotes a 10 -fold acceleration of the rate of electron transfer. Here we describe kinetic, spectroscopic, and computational results to show that CoA has no effect on catalysis by OOR and describe the chemical rationale for why this cofactor is unnecessary in this enzymatic transformation. Our results demonstrate that, like PFOR, OOR binds pyruvate and catalyzes decarboxylation to form the same hydroxyethylidine-TPP (HE-TPP) intermediate and one-electron transfer to generate the HE-TPP radical. However, in OOR, this intermediate remains stranded at the active site as a covalent inhibitor. These and other results indicate that, like other OFOR family members, OOR generates an oxalate-derived adduct with TPP (oxalyl-TPP) that undergoes decarboxylation and one-electron transfer to form a radical intermediate remaining bound to TPP (dihydroxymethylidene-TPP). However, unlike in PFOR, where CoA binding drives formation of the product, in OOR, proton transfer and a conformational change in the "switch loop" alter the redox potential of the radical intermediate sufficiently to promote the transfer of an electron into the iron-sulfur cluster network, leading directly to a second decarboxylation and completing the catalytic cycle.
[Mh] Termos MeSH primário: Oxalatos/metabolismo
Oxirredutases/metabolismo
Ácido Pirúvico/metabolismo
[Mh] Termos MeSH secundário: Catálise
Espectroscopia de Ressonância de Spin Eletrônica
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); 8558G7RUTR (Pyruvic Acid); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00222


  4 / 5709 MEDLINE  
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[PMID]:28505577
[Au] Autor:Jiang B; Xin S; He H; Liu X; Gao L; Tang Y; Bi X
[Ad] Endereço:School of Environmental and Municipal Engineering, Qingdao University Technology, Qingdao 266033, PR China; State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Qingdao 266580, Shandong, PR China.
[Ti] Título:Evaluation of the photooxidation efficiency of As(III) applying the UVC/oxalate technique.
[So] Source:Chemosphere;182:356-363, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the photooxidation capacity of UVC/Oxalate (Ox) was evaluated using As(III) as a typical pollutant. The results show that the direct oxidation amount of As(III) induced by UVC in water was negligible, but the presence of Ox remarkably accelerated the oxidation rate of As(III). Under UVC irradiation, 50 µM As(III) can be completely oxidized to As(V) in the case of Ox concentration above 300 µM within 60 min. As(III) oxidation was found greatly related with the photodecomposition of Ox. Much more Ox can be mineralized in more acidic solution. At the same time, the photooxidation of As(III) was significantly favored at decreased initial pH from 8.0 to 3.0. In this reaction system, the role of oxygen was indispensable for Ox photodecomposition and As(III) photooxidation, which can be ascribed to its special roles as a precursor of reactive superoxide and an electron acceptor. In oxygen-present atmosphere, the in situ production of H O was detected during the photolysis of Ox and its photolysis product, i.e., OH primarily contributed to the oxidation of As(III). However, the photodecomposition of Ox and photooxidation of As(III) were significantly inhibited in the anaerobic environment. In general, the homogeneous photolysis of Ox in many commonly practiced UVC oxidation processes can be also proposed as a supplementary method of generating highly oxiditive species in aerobic condition.
[Mh] Termos MeSH primário: Arsênico/química
Oxalatos/química
Raios Ultravioleta
[Mh] Termos MeSH secundário: Arsênico/efeitos da radiação
Peróxido de Hidrogênio/química
Concentração de Íons de Hidrogênio
Oxirredução
Fotólise
Superóxidos
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); 0 (Water Pollutants, Chemical); 11062-77-4 (Superoxides); BBX060AN9V (Hydrogen Peroxide); N712M78A8G (Arsenic)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


  5 / 5709 MEDLINE  
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[PMID]:28412486
[Au] Autor:Jiang J; Yang M; Gao Y; Wang J; Li D; Li T
[Ad] Endereço:School of Environment, Tsinghua University, Beijing, 100084, China; Key Laboratory of Solid Waste Management and Environment Safety (Tsinghua University), Ministry of Education, Tsinghua University, Beijing, 100084, China; Collaborative Innovation Center for Regional Environmental Quality, Tsinghua
[Ti] Título:Removal of toxic metals from vanadium-contaminated soils using a washing method: Reagent selection and parameter optimization.
[So] Source:Chemosphere;180:295-301, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vanadium (V) contamination in soils is an increasing worldwide concern facing human health and environmental conservation. The fractionation of a metal influences its mobility and biological toxicity. We analyzed the fractionations of V and several other metals using the BCR three-step sequential extraction procedure. Among methods for removing metal contamination, soil washing is an effective permanent treatment. We conducted experiments to select the proper reagents and to optimize extraction conditions. Citric acid, tartaric acid, oxalic acid, and Na EDTA all exhibited high removal rates of the extractable state of V. With a liquid-to-solid ratio of 10, washing with 0.4 mol/L citric acid, 0.4 mol/L tartaric acid, 0.4 mol/L oxalic acid, and 0.12 mol/L Na EDTA led to removal rates of 91%, 88%, 88%, and 61%, respectively. The effect of multiple washing on removal rate was also explored. According to the changes observed in metal fractionations, differences in removal rates among reagents is likely associated with their pK value, pH in solution, and chemical structure. We concluded that treating with appropriate washing reagents under optimal conditions can greatly enhance the remediation of vanadium-contaminated soils.
[Mh] Termos MeSH primário: Recuperação e Remediação Ambiental/métodos
Poluentes do Solo/análise
Vanádio/análise
[Mh] Termos MeSH secundário: Fracionamento Químico
Ácido Cítrico
Poluição Ambiental
Seres Humanos
Indicadores e Reagentes
Oxalatos/química
Solo/química
Tartaratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indicators and Reagents); 0 (Oxalates); 0 (Soil); 0 (Soil Pollutants); 0 (Tartrates); 00J9J9XKDE (Vanadium); 2968PHW8QP (Citric Acid); W4888I119H (tartaric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


  6 / 5709 MEDLINE  
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[PMID]:28402768
[Au] Autor:Jiang D; Geng H
[Ad] Endereço:Xinhua Hospital, Shanghai, China.
[Ti] Título:Primary Hyperoxaluria.
[So] Source:N Engl J Med;376(15):e33, 2017 Apr 13.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hiperoxalúria Primária/diagnóstico
Transaminases/genética
[Mh] Termos MeSH secundário: Pré-Escolar
Hematúria/etiologia
Seres Humanos
Hiperoxalúria Primária/complicações
Hiperoxalúria Primária/genética
Cálculos Renais/diagnóstico por imagem
Cálculos Renais/etiologia
Masculino
Oxalatos/urina
Radiografia Abdominal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); EC 2.6.1.- (Transaminases); EC 2.6.1.44 (Alanine-glyoxylate transaminase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1609986


  7 / 5709 MEDLINE  
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[PMID]:28392511
[Au] Autor:Jaturakan O; Dissayabutra T; Chaiyabutr N; Kijtawornrat A; Tosukhowong P; Rungsipipat A; Nhujak T; Buranakarl C
[Ad] Endereço:Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
[Ti] Título:Combination of vitamin E and vitamin C alleviates renal function in hyperoxaluric rats via antioxidant activity.
[So] Source:J Vet Med Sci;79(5):896-903, 2017 May 18.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Hyperoxaluria and oxidative stress are risk factors in calcium oxalate (CaOx) stone formation. Supplement with antioxidant could be effective in prevention of recurrent stone formation. The present study aims to evaluate the protective effects of vitamin E and vitamin C in hyperoxaluric rat. The experiment was performed in rats for 21 days. Rats were divided into 5 groups as follows: control (group 1, n=8), hyperoxaluric rats (group 2, n=8), hyperoxaluric rats with vitamin E supplement (group 3, n=7), hyperoxaluric rats with vitamin C supplement (group 4, n=7) and hyperoxaluric rats with vitamin E and C supplement (group 5, n=7). Hyperoxaluria was induced by feeding hydroxyl L-proline (HLP) 2% w/v dissolved in drinking water. Intraperitoneal 200 mg/kg of vitamin E was given in groups 3 and 5 on days 1, 6, 11 and 16, while 500 mg of vitamin C was injected intravenously in groups 4 and 5 on days 1 and 11. Renal functions and oxidative status were measured. The urinary oxalate excretion was increased in HLP supplement rats, while glomerular filtration rate, proximal water and sodium reabsorption were significantly lower in group 2 compared with a control (P<0.05). Giving antioxidants significantly lower urinary calcium oxalate crystals (P<0.05). Hyperoxaluric rats had higher plasma malondialdehyde (PMDA) and lower urinary total antioxidant status (UTAS), which were alleviated by vitamin E and/or vitamin C supplement. In conclusion, giving combination of vitamin E and vitamin C exerts a protective role against HLP-induced oxalate nephropathy.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Ácido Ascórbico/uso terapêutico
Hiperoxalúria/tratamento farmacológico
Rim/efeitos dos fármacos
Vitamina E/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Ácido Ascórbico/administração & dosagem
Peso Corporal
Citratos/urina
Ingestão de Líquidos
Quimioterapia Combinada
Ingestão de Alimentos
Eletrólitos/metabolismo
Hemodinâmica
Hiperoxalúria/patologia
Rim/patologia
Cálculos Renais/prevenção & controle
Glomérulos Renais/efeitos dos fármacos
Glomérulos Renais/fisiologia
Masculino
Oxalatos/urina
Substâncias Protetoras/uso terapêutico
Ratos
Ratos Sprague-Dawley
Vitamina E/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Citrates); 0 (Electrolytes); 0 (Oxalates); 0 (Protective Agents); 1406-18-4 (Vitamin E); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.17-0083


  8 / 5709 MEDLINE  
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[PMID]:28351009
[Au] Autor:Montgomery D; Barber K; Edayilam N; Oqujiuba K; Young S; Biotidara T; Gathers A; Danjaji M; Tharayil N; Martinez N; Powell B
[Ad] Endereço:Clemson University, Clemson, SC 29634, United States. Electronic address: damontg@clemson.edu.
[Ti] Título:The influence of citrate and oxalate on Tc , Cs, Np and U sorption to a Savannah River Site soil.
[So] Source:J Environ Radioact;172:130-142, 2017 Jun.
[Is] ISSN:1879-1700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Batch sorption experiments were conducted with 0.5-50 ppb Tc, Cs, Np and U in the presence and absence of citrate and/or oxalate in a 25 g/L Savannah River Site (SRS) soil suspension. Citrate and oxalate were the ligands of choice due to their relevancy to plant exudates, the nuclides were selected for their wide range of biogeochemical behavior, and the soil from SRS was selected as a model Department of Energy (DOE) site soil. Batch samples were continually mixed on a rotary shaker and maintained at a pH of approximately 5. Analysis via ICP-MS indicated that sorption of Np increased with ligand concentration compared to baseline studies, as did sorption of Tc although to a lesser extent. The increased sorption of Np is proposed to be due to a combination of factors that are dependent on the ligand(s) present in the specific system including, ligand dissolution of the soil by citrate and formation of tertiary soil-oxalate-Np complexes. The increased Tc sorption is attributed to the dissolution of the soil by the ligands, leading to an increase in the number of available sorption sites for Tc. Uranium sorption decreased and dissolution of native uranium was also observed with increasing ligand concentration, thought to be a result of the formation of strong U-ligand complexes remaining in the aqueous phase. The majority of these effects were observed at the highest ligand concentrations of 50 mg /L. No notable changes were observed for the Cs system which is ascribed to the minimal interaction of Cs with these organic ligands.
[Mh] Termos MeSH primário: Radioisótopos de Césio/análise
Ácido Cítrico/química
Oxalatos/química
Tecnécio/análise
Urânio/análise
[Mh] Termos MeSH secundário: Adsorção
Georgia
Modelos Químicos
Poluentes Radioativos do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cesium Radioisotopes); 0 (Oxalates); 0 (Soil Pollutants, Radioactive); 2968PHW8QP (Citric Acid); 4OC371KSTK (Uranium); 7440-26-8 (Technetium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE


  9 / 5709 MEDLINE  
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[PMID]:28261895
[Au] Autor:Villani V; Gupta N; Elias N; Vagefi PA; Markmann JF; Paul E; Traum AZ; Yeh H
[Ad] Endereço:Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
[Ti] Título:Bilateral native nephrectomy reduces systemic oxalate level after combined liver-kidney transplant: A case report.
[So] Source:Pediatr Transplant;21(3), 2017 May.
[Is] ISSN:1399-3046
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Primary hyperoxaluria type 1 (PH1) is a rare liver enzymatic defect that causes overproduction of plasma oxalate. Accumulation of oxalate in the kidney and subsequent renal failure are fatal to PH1 patients often in pediatric age. Combined liver and kidney transplantation is the therapy of choice for end-stage renal disease due to PH1. Levels of plasma oxalate remain elevated for several months after liver transplantation, as the residual body oxalate is slowly excreted. Patients with persistent hyperoxaluria after transplant often require hemodialysis, and accumulation of residual oxalate in the kidney can induce graft dysfunction. As the native kidneys are the main target of calcium oxalate accumulation, we postulated that removal of native kidneys could drastically decrease total body oxalate levels after transplantation. Here, we report a case of bilateral nephrectomy at the time of combined liver-kidney transplantation in a pediatric PH1 patient. Bilateral nephrectomy induced a rapid decrease in plasma oxalate to normal levels in less than 20 days, compared to the several months reported in the literature. Our results suggest that removal of native kidneys could be an effective strategy to decrease the need for hemodialysis and the risk of renal dysfunction after combined liver-kidney transplantation in patients with PH1.
[Mh] Termos MeSH primário: Hiperoxalúria Primária/cirurgia
Falência Renal Crônica/cirurgia
Transplante de Rim/métodos
Transplante de Fígado/métodos
Oxalatos/sangue
[Mh] Termos MeSH secundário: Criança
Feminino
Taxa de Filtração Glomerular
Seres Humanos
Hiperoxalúria/sangue
Rim/fisiopatologia
Nefrectomia
Diálise Renal
Insuficiência Renal/complicações
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Oxalates)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1111/petr.12901


  10 / 5709 MEDLINE  
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[PMID]:28125004
[Au] Autor:Kizivat T; Smolic M; Maric I; Tolusic Levak M; Smolic R; Bilic Curcic I; Kuna L; Mihaljevic I; Vcev A; Tucak-Zoric S
[Ad] Endereço:Clinical Hospital Osijek, Josipa Huttlera 4, HR-31000 Osijek, Croatia. tomislavkizivat@gmail.com.
[Ti] Título:Antioxidant Pre-Treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis.
[So] Source:Int J Environ Res Public Health;14(1), 2017 Jan 23.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Urolithiasis is characterized by the formation and retention of solid crystals within the urinary tract. Kidney stones are mostly composed of calcium oxalate, which predominantly generates free radicals that are toxic to renal tubular cells. The aim of the study is to explore possible effects of antioxidant pre-treatment on inhibition of oxidative stress. Three cell lines were used as in vitro model of urolithiasis: MDCK I, MDCK II and LLC-PK1. Oxidative stress was induced by exposure of cells to sodium oxalate in concentration of 8 mM. In order to prevent oxidative stress, cells were pre-treated with three different concentrations of l-arginine and vitamin E. Oxidative stress was evaluated by determining the expression of superoxide dismutase (SOD), osteopontin (OPN), and by the concentration of glutathione (GSH). In all three cell lines, pre-treatment of antioxidants increased cell survival. Positive correlation of SOD and OPN expression as well as GSH concentration was observed in all groups of cells. Our results indicate that an antioxidant pre-treatment with l-arginine and vitamin E is able to hamper oxalate-induced oxidative stress in kidney epithelial cells and as such could play a role in prevention of urolithiasis.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Células Epiteliais/efeitos dos fármacos
Rim/efeitos dos fármacos
Oxalatos/toxicidade
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Arginina/farmacologia
Linhagem Celular
Cães
Glutationa/metabolismo
Osteopontina/metabolismo
Superóxido Dismutase/metabolismo
Suínos
Vitamina E/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oxalates); 106441-73-0 (Osteopontin); 1406-18-4 (Vitamin E); 94ZLA3W45F (Arginine); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE



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