Base de dados : MEDLINE
Pesquisa : D02.241.081.337.593.750.500 [Categoria DeCS]
Referências encontradas : 3715 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 372 ir para página                         

  1 / 3715 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28458427
[Au] Autor:Panigrahi PN; Dey S; Sahoo M; Dan A
[Ad] Endereço:Division of Medicine, Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
[Ti] Título:Antiurolithiatic and antioxidant efficacy of pseudostem on ethylene glycol-induced nephrolithiasis in rat.
[So] Source:Indian J Pharmacol;49(1):77-83, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: has been used in the treatment of urolithiasis by the rural people in South India. Therefore, we plan to evaluate its efficacy and possible mechanism of antiurolithiatic effect to rationalize its medicinal use. MATERIALS AND METHODS: Urolithiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol (EG) for 28 days along with 1% ammonium chloride (AC) for the first 14 days. Antiurolithiatic effect of aqueous-ethanol extract of pseudostem (MUSA) was evaluated based on urine and serum biochemistry, microscopy of urine, oxidative/nitrosative indices, kidney calcium content, and histopathology. RESULTS: Administration of EG and AC resulted in increased crystalluria and oxaluria, hypercalciuria, polyuria, crystal deposition in urine, raised serum urea, and creatinine as well as nitric oxide concentration and erythrocytic lipid peroxidation in lithiatic group. However, MUSA treatment significantly restored the impairment in above kidney function test as that of standard treatment, cystone in a dose-dependent manner. CONCLUSIONS: The present findings demonstrate the efficacy of MUSA in EG-induced urolithiasis, which might be mediated through inhibiting various pathways involved in renal calcium oxalate formation, antioxidant effect, and potential to inhibit biochemical markers of renal impairment.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Musa/química
Nefrolitíase/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Cloreto de Amônio/toxicidade
Animais
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Oxalato de Cálcio/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Etilenoglicol/toxicidade
Índia
Testes de Função Renal
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Nefrolitíase/fisiopatologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (cystone); 01Q9PC255D (Ammonium Chloride); 2612HC57YE (Calcium Oxalate); FC72KVT52F (Ethylene Glycol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201026


  2 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29020580
[Au] Autor:Hanouneh M; Chen TK
[Ad] Endereço:Johns Hopkins University, Baltimore, MD mhanoun1@jhmi.edu.
[Ti] Título:Calcium Oxalate Crystals in Ethylene Glycol Toxicity.
[So] Source:N Engl J Med;377(15):1467, 2017 Oct 12.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Oxalato de Cálcio/urina
Etilenoglicol/envenenamento
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Etilenoglicol/sangue
Etilenoglicol/urina
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2612HC57YE (Calcium Oxalate); FC72KVT52F (Ethylene Glycol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1704369


  3 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28952687
[Au] Autor:Kustov AV; Strelnikov AI; Moryganov MA; Airapetyan AO; Smirnov PR; Lyalyakina EV; Toms SR
[Ad] Endereço:United Physico-Chemical Center of Solutions, G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences and Ivanovo State University of Chemical Technology, Ivanovo, Russia.
[Ti] Título:[Mineralogical composition of urinary stones, risk factors and metabolic disturbances in patients with calcium-oxalate urolithiasis].
[So] Source:Urologiia;(4):22-26, 2017 Sep.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To identify the most likely metabolic disturbances and risk factors for stone formation in a group of patients with calcium oxalate urolithiasis, and to establish the relationship between the mineralogical composition of calculi and impaired excretion of inhibitors and promoters of stone formation. MATERIALS AND METHODS: Fifty patients with calcium oxalate urolithiasis were tested using a complex of physicochemical methods. Patients assessment included evaluation of quantitative mineralogical composition of calculi, daily urine pH profile and daily urinary excretion of urates, calcium, magnesium, oxalate, phosphate and citrate ions. RESULTS: The main mineralogical phase of the stones in over 80% of patients was calcium oxalate monohydrate; none of the patients had pure dihydrate stones. The most frequent metabolic disorders were hypocitraturia, hypercalciuria and hyperuricosuria. Predominant risk factors were excessive body weight and insufficient fluid intake. Only one patient had an idiopathic stone formation. It was established for the first time that patients with calcium oxalate stones, containing 10 or more mass percent of apatites had statistically significantly lower daily urinary calcium and oxalate excretion and simultaneously increased phosphate excretion. CONCLUSIONS: The study findings showed that patients with calculi based on calcium oxalate dihydrate should undergo testing for daily urinary excretion of calcium and citrate while pa-tients with calcium oxalate stones containing 10 or more mass percent of apatites should also be tested for daily phosphate excretion and urine pH-profile. Daily urinary citrate excretion was reduced in all study patients, and urate excretion was significantly increased, apparently due to an imbalanced diet and excessive intake of animal protein. Menopausal and postmenopausal women are at a particular risk due to low urinary citrate excretion and high urinary calcium excretion regardless of stone composition.
[Mh] Termos MeSH primário: Oxalato de Cálcio/análise
Urolitíase/metabolismo
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Feminino
Seres Humanos
Masculino
Meia-Idade
Cálculos Urinários/química
Cálculos Urinários/metabolismo
Urodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  4 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28846699
[Au] Autor:Kaushik J; Tandon S; Gupta V; Nayyar J; Singla SK; Tandon C
[Ad] Endereço:Amity Institute of Biotechnology, Amity University, Noida, India.
[Ti] Título:Response surface methodology based extraction of Tribulus terrestris leads to an upsurge of antilithiatic potential by inhibition of calcium oxalate crystallization processes.
[So] Source:PLoS One;12(8):e0183218, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tribulus terrestris has significant antilithiatic efficacy established via both in vitro as well as in vivo studies and is used in numerous anti-urolithiatic herbal formulations viz. Cystone, Uriflow, Uritone and Neeri. However, to fully utilize its antilithiatic potential, the influence of different extraction parameters on antilithiatic ability of T. terrestris aqueous extract needs elucidation. Thus, the current study was undertaken using statistically optimized extraction conditions for aqueous extract preparation. Response surface methodology was employed to observe the influence of three variables i.e. temperature (°C), time (h) and solid: liquid ratio (S: L) on the extraction yield (%) and protein content (mg/g) of T. terrestris aqueous extract. RSM results revealed that the high S:L ratio, low temperature and reduced incubation time were optimal conditions for aqueous extraction. Under such extraction conditions the protein content reached the value of 26.6±1.22 mg/g and the obtained extraction yield was 27.32±1.62%. The assessment of antilithiatic activity of 4 selected extracts (AE1-4), revealed enhanced nucleation and aggregation inhibition of calcium oxalate crystals with AE1 and AE2, which in addition significantly altered the size and morphology of calcium oxalate monohydrate (COM) crystals compared to AE3 and AE4. In vitro cell culture based studies on renal epithelial cells (MDCK, NRK-52E and PK 15) proved that the AE1 showed higher cytoprotective potency by increasing cell viability as compared to the oxalate treated group. The free radical scavenging activity of aqueous extract lowered the reactive oxygen specie's induced damage and potentially reduced the signals of programmed cell death due to oxalate injury. In addition, modulation of the COM crystal morphology was enhanced by AE1 as compared to AE2. The FTIR and GC-MS analysis of AE1, showed the presence of biomolecules which could aid in the attenuation of lithiatic process. In the light of these results the utility of the RSM approach to fully optimize the antilithiatic potential of T. terrestris cannot be undermined.
[Mh] Termos MeSH primário: Oxalato de Cálcio/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Células Epiteliais/efeitos dos fármacos
Rim/efeitos dos fármacos
Extratos Vegetais/farmacologia
Tribulus
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Cristalização
Cães
Células Epiteliais/metabolismo
Rim/metabolismo
Ratos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183218


  5 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28739328
[Au] Autor:Marques S; Santos S; Fremin K; Fogo AB
[Ad] Endereço:Department of Nephrology, Centro Hospitalar São João, Porto, Portugal; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN. Electronic address: sofiahomemdemelo@gmail.com.
[Ti] Título:A Case of Oxalate Nephropathy: When a Single Cause Is Not Crystal Clear.
[So] Source:Am J Kidney Dis;70(5):722-724, 2017 Nov.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyperoxaluria can result in oxalate nephropathy with intratubular calcium oxalate crystallization and acute tubular injury. Primary inherited enzymatic deficiency or secondary causes such as excessive dietary intake, enteric increased absorption, or high doses of vitamin C, which is metabolized to oxalate, may underlie hyperoxaluria and oxalate nephropathy. We report a case of acute kidney injury due to oxalate nephropathy in a patient using chelating therapy with oral ethylenediamine tetra acetic acid (EDTA), intravenous supplementation with vitamin C, and chronic diarrhea and discuss the potential kidney damage these factors can cause in particular settings. To our knowledge, this is the first report suggesting an association between oral EDTA and oxalate nephropathy.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Ácido Ascórbico/efeitos adversos
Quelantes de Cálcio/efeitos adversos
Oxalato de Cálcio
Diarreia/complicações
Ácido Edético/efeitos adversos
Hiperoxalúria/etiologia
Vitaminas/efeitos adversos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/patologia
Lesão Renal Aguda/terapia
Idoso
Seres Humanos
Necrose Tubular Aguda/etiologia
Necrose Tubular Aguda/patologia
Masculino
Diálise Renal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Chelating Agents); 0 (Vitamins); 2612HC57YE (Calcium Oxalate); 9G34HU7RV0 (Edetic Acid); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  6 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28739184
[Au] Autor:Bischetti S; Scimeca M; Bonanno E; Federici M; Anemona L; Menghini R; Casella S; Cardellini M; Ippoliti A; Mauriello A
[Ad] Endereço:Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy. Electronic address: simone.bischetti@gmail.com.
[Ti] Título:Carotid plaque instability is not related to quantity but to elemental composition of calcification.
[So] Source:Nutr Metab Cardiovasc Dis;27(9):768-774, 2017 Sep.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Recent studies highlighted the role of calcification processes in the clinical progression of chronic cardiovascular diseases. In this study we investigated the relationship between the chemical composition of calcification and atherosclerotic plaque stability in carotid arteries. METHODS AND RESULTS: To this end, we characterized the calcification on 229 carotid plaques, by morphology, immunohistochemistry, transmission electron microscopy and energy dispersive X-ray microanalysis. Plaques were classified into two categories: unstable and stable. No significant differences were found in the incidence of the various risk factors between patients with and without carotid calcification, with the exception of diabetes. The energy dispersive X-ray microanalysis allowed us to identify two types of calcium salts in the atheromatous plaques, hydroxyapatite (HA) and calcium oxalate (CO). Our results showed that calcification is a common finding in carotid plaques, being present in 77.3% of cases, and the amount of calcium is not a factor of vulnerability. Noteworthy, we observed an association between HA calcification and unstable plaques. On the contrary, CO calcifications were mainly detected in stable plaques. CONCLUSIONS: The presence of different types of calcification in atheromatous plaques may open new perspectives in understanding the molecular mechanisms of atheroma formation and plaque instability.
[Mh] Termos MeSH primário: Oxalato de Cálcio/análise
Artérias Carótidas/química
Doenças das Artérias Carótidas/metabolismo
Durapatita/análise
Placa Aterosclerótica
Calcificação Vascular/metabolismo
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/análise
Biópsia
Artérias Carótidas/ultraestrutura
Doenças das Artérias Carótidas/patologia
Progressão da Doença
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Microscopia Eletrônica de Transmissão
Meia-Idade
Fatores de Risco
Ruptura Espontânea
Espectrometria por Raios X
Calcificação Vascular/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 2612HC57YE (Calcium Oxalate); 91D9GV0Z28 (Durapatite)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  7 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28442375
[Au] Autor:Bhardwaj R; Bhardwaj A; Tandon C; Dhawan DK; Bijarnia RK; Kaur T
[Ad] Endereço:Department of Biophysics, Panjab University, Chandigarh, India.
[Ti] Título:Implication of hyperoxaluria on osteopontin and ER stress mediated apoptosis in renal tissue of rats.
[So] Source:Exp Mol Pathol;102(3):384-390, 2017 Jun.
[Is] ISSN:1096-0945
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hyperoxaluria is a stress that leads to calcium oxalate crystal deposition which further causes inflammation and renal cell necroptosis. Many studies have linked osteopontin expression with apoptosis and inflammation but so far its association with apoptosis with regard to hyperoxaluria is undiscovered. Moreover, a recent report has suggested that osteopontin induces endoplasmic reticulum stress and subsequently apoptosis in myocytes. In this study, the impact of hyperoxaluria on the modulation of osteopontin expression and endoplasmic reticulum (ER) stress mediated apoptosis in rats is explored. Hyperoxaluria was induced in rats by three different doses viz. ethylene glycol alone, ethylene glycol and ammonium chloride together and third group were fed with hydroxyl-l-proline. After hyperoxaluria induction rats were sacrificed and renal tissue was analysed for crystal depositions, osteopontin expression, inflammation, ER stress and subsequent unfolded protein response intermediates (UPR). Altered histoarchitecture of renal tissue and elevated levels of reactive oxygen species (ROS) along with the presence of calcium oxalate crystals were observed in the hyperoxaluric groups. As expected, inflammation and apoptosis was significantly high in all hyperoxaluria groups. Osteopontin expression showed significant up-regulation following hyperoxaluria. Further, a similar trend between expression of osteopontin and elevated ER stress level was observed. Moreover, UPR intermediates expression was also concurrent with osteopontin levels. It is observed that the extent of calcium oxalate crystal deposition is directly associated with the expression of osteopontin, inflammation and ER stress. The results advocate possible association of osteopontin with ER stress, thus suggesting that the ER could be a new target for developing therapeutic regimes for kidney stones.
[Mh] Termos MeSH primário: Apoptose
Estresse do Retículo Endoplasmático/genética
Hiperoxalúria/patologia
Rim/patologia
Osteopontina/metabolismo
[Mh] Termos MeSH secundário: Animais
Oxalato de Cálcio/metabolismo
Modelos Animais de Doenças
Proteínas de Choque Térmico/genética
Proteínas de Choque Térmico/metabolismo
Masculino
Osteopontina/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Resposta a Proteínas não Dobradas
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heat-Shock Proteins); 0 (Hspa5 protein, rat); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 0 (Spp1 protein, rat); 106441-73-0 (Osteopontin); 2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


  8 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28342804
[Au] Autor:Plante G; Ouimet D; Robitaille R
[Ad] Endereço:Division of Clinical Biochemistry, CIUSSS de l'Est-de-l'Île-de-Montréal, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada. Electronic address: genevieve.plante@umontreal.ca.
[Ti] Título:Easy-to-use equations for the estimation of urine relative saturation in the assessment of risk of recurrence in urinary stones formers.
[So] Source:Clin Biochem;50(13-14):794-796, 2017 Sep.
[Is] ISSN:1873-2933
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is a fact that recurrence of urinary stones is a common medical problem. One of the key factors used in determining the risk of urinary stone-formation is the urine relative saturation in the major constituents of lithiasis. Nomograms were developed in the 1970's to estimate the relative saturation of urine. We present here easy-to-use mathematical equations derived from these nomograms. These equations can be integrated directly in the LIS of any laboratories, and can be used as a tool in the treatment and prevention of recurrent stone-formation.
[Mh] Termos MeSH primário: Cálculos Renais/química
Modelos Biológicos
Cálculos Urinários/urina
[Mh] Termos MeSH secundário: Algoritmos
Amônia/urina
Cálcio/urina
Oxalato de Cálcio/análise
Fosfatos de Cálcio/análise
Cisteína/urina
Cistina/análise
Hospitais Urbanos
Seres Humanos
Concentração de Íons de Hidrogênio
Magnésio/urina
Ácido Oxálico/urina
Fosfatos/urina
Quebeque/epidemiologia
Recidiva
Indução de Remissão
Fatores de Risco
Estruvita/análise
Ácido Úrico/análise
Cálculos Urinários/epidemiologia
Cálculos Urinários/terapia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Phosphates); 13767-12-9 (octacalcium phosphate); 2612HC57YE (Calcium Oxalate); 268B43MJ25 (Uric Acid); 48TCX9A1VT (Cystine); 7664-41-7 (Ammonia); 9E7R5L6H31 (Oxalic Acid); AW3EJL1462 (Struvite); I38ZP9992A (Magnesium); K848JZ4886 (Cysteine); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE


  9 / 3715 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28335665
[Au] Autor:Yu L; Gan X; Liu X; An R
[Ad] Endereço:a Department of Urology , the First Affiliated Hospital of Harbin Medical University , Harbin , Heilongjiang Province , P.R. China.
[Ti] Título:Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway.
[So] Source:Ren Fail;39(1):440-451, 2017 Nov.
[Is] ISSN:1525-6049
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tight junction plays important roles in regulating paracellular transports and maintaining cell polarity. Calcium oxalate monohydrate (COM) crystals, the major crystalline composition of kidney stones, have been demonstrated to be able to cause tight junction disruption to accelerate renal cell injury. However, the cellular signaling involved in COM crystal-induced tight junction disruption remains largely to be investigated. In the present study, we proved that COM crystals induced tight junction disruption by activating ROS/Akt/p38 MAPK pathway. Treating Madin-Darby canine kidney (MDCK) cells with COM crystals induced a substantial increasing of ROS generation and activation of Akt that triggered subsequential activation of ASK1 and p38 mitogen-activated protein kinase (MAPK). Western blot revealed a significantly decreased expression of ZO-1 and occludin, two important structural proteins of tight junction. Besides, redistribution and dissociation of ZO-1 were observed by COM crystals treatment. Inhibition of ROS by N-acetyl-l-cysteine (NAC) attenuated the activation of Akt, ASK1, p38 MAPK, and down-regulation of ZO-1 and occludin. The redistribution and dissociation of ZO-1 were also alleviated by NAC treatment. These results indicated that ROS were involved in the regulation of tight junction disruption induced by COM crystals. In addition, the down-regulation of ZO-1 and occludin, the phosphorylation of ASK1 and p38 MAPK were also attenuated by MK-2206, an inhibitor of Akt kinase, implying Akt was involved in the disruption of tight junction upstream of p38 MAPK. Thus, these results suggested that ROS-Akt-p38 MAPK signaling pathway was activated in COM crystal-induced disruption of tight junction in MDCK cells.
[Mh] Termos MeSH primário: Oxalato de Cálcio/metabolismo
Células Epiteliais/metabolismo
Túbulos Renais/citologia
Nefrolitíase/metabolismo
Transdução de Sinais
Junções Íntimas/metabolismo
[Mh] Termos MeSH secundário: Acetilcisteína/farmacologia
Animais
Apoptose
Células Cultivadas
Cães
Regulação para Baixo
Compostos Heterocíclicos com 3 Anéis/farmacologia
Seres Humanos
Cálculos Renais/química
Células Madin Darby de Rim Canino
Ocludina/metabolismo
Fosforilação
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-akt/metabolismo
Espécies Reativas de Oxigênio/antagonistas & inibidores
Espécies Reativas de Oxigênio/metabolismo
Proteína da Zônula de Oclusão-1/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heterocyclic Compounds, 3-Ring); 0 (MK 2206); 0 (Occludin); 0 (Reactive Oxygen Species); 0 (Zonula Occludens-1 Protein); 2612HC57YE (Calcium Oxalate); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1080/0886022X.2017.1305968


  10 / 3715 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:28221144
[Au] Autor:Grases F; Costa-Bauzá A; Prieto RM
[Ad] Endereço:Laboratorio de Investigación en Litiasis Renal. Instituto Universitario de Investigación en Ciencias de la Salud (IUNICSIdISPa). Universitat de les Illes Balears. Palma de Mallorca. Illes Balears. España.
[Ti] Título:[May renal lithiasis be really prevented? New trends and therapeutic tools.]
[Ti] Título:Se puede realmente prevenir la litiasis renal? Nuevas tendencias y herramientas terapéuticas..
[So] Source:Arch Esp Urol;70(1):91-102, 2017 Jan.
[Is] ISSN:0004-0614
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:Renal calculi are generally formed as a result of the combination of certain factors, some related to urine composition (concentration of lithogenic substances, deficiency of crystallization inhibitors, presence of heterogeneous nucleants) and others with renal morphology and anatomy (urinary tract stasis, low urodynamic efficiency cavities, morpho-anatomic deformations, renal papillary tissue lesions). In fact, the composition, macrostructure and microstructure of the calculus will clearly depend on the factors that have induced it. For this reason, the appropriate study and classification of the renal calculi simplifies the diagnosis and allows a more effective therapeutic approach since it can be oriented to directly correct the etiological factors responsible for stone formation. In this article, we review the main etiological factors involved in the formation of each type of calculus and the prophylactic measures that can be adopted for proper correction. The most frequent kidney stones have been classified into the following types: calcium oxalate monohydrate papillary calculi, calcium oxalate monohydrate non-papillary calculi, calcium oxalate dihydrate calculi, mixed hydroxyapatite/ calcium oxalate calculi, carboxyapatite/hydroxyapatite calculi, brushite calculi, struvite/carboxyapatite calculi, uric acid calculi, uric acid/calcium oxalate monohydrate calculi, and cystine calculi. Occasionally, however, the calculus is not available for study, in which case the only way forward is to use all available information (clinical history, life habits, radiological data), together with basic biochemical information, to identify and correct all etiological factors related to renal lithiasis that have been identified.
[Mh] Termos MeSH primário: Cálculos Renais/prevenção & controle
[Mh] Termos MeSH secundário: Oxalato de Cálcio/análise
Seres Humanos
Cálculos Renais/química
Cálculos Renais/etiologia
Guias de Prática Clínica como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
2612HC57YE (Calcium Oxalate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE



página 1 de 372 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde