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[PMID]:29441997
[Au] Autor:Bhunchu S; Muangnoi C; Rojsitthisak P; Rojsitthisak P
[Ti] Título:Curcumin diethyl disuccinate encapsulated in chitosan/alginate nanoparticles for improvement of its cytotoxicity against MDA-MB-231 human breast cancer cells.
[So] Source:Pharmazie;71(12):691-700, 2016 Dec 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Curcumin diethyl disuccinate (CDD) is a succinate prodrug of curcuminoids that has better stability in human plasma and improved in vitro cytotoxicity compared to curcumin. Therefore, CDD has the potential for further development as an anticancer agent. In this study, we focused on optimization of the formulation of CDD-loaded chitosan/alginate nanoparticles using Box-Behnken statistical design to enhance the therapeutic efficacy of CDD. Oil-in-water emulsification followed by ionotropic gelification was used to prepare the CDD-loaded chitosan/ alginate nanoparticles. A formulation with a 0.05:1 chitosan/alginate mass ratio, 0.65% (w/v) Pluronic F127 and 1.5 mg/ml CDD was found to be optimal. FTIR, TGA and XRD confirmed the encapsulation of CDD molecules in the nanoparticles. In vitro cytotoxicity and cellular uptake studies showed that CDD-loaded chitosan/alginate nanoparticles had significantly higher cytotoxicity and cellular uptake in human breast adenocarcinoma MDA-MB-231 cells, compared to free CDD. Physical and chemical stability studies indicated that the optimally formulated CDD-loaded chitosan/alginate nanoparticles were stable at 4 °C for 3 months.
[Mh] Termos MeSH primário: Alginatos/química
Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/farmacologia
Neoplasias da Mama/tratamento farmacológico
Quitosana/química
Curcumina/análogos & derivados
Excipientes/química
Nanopartículas
Succinatos/administração & dosagem
Succinatos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacocinética
Neoplasias da Mama/metabolismo
Linhagem Celular Tumoral
Curcumina/administração & dosagem
Curcumina/farmacocinética
Curcumina/farmacologia
Composição de Medicamentos
Estabilidade de Medicamentos
Emulsões
Feminino
Seres Humanos
Poloxâmero
Pró-Fármacos
Succinatos/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Antineoplastic Agents, Phytogenic); 0 (Emulsions); 0 (Excipients); 0 (Prodrugs); 0 (Succinates); 0 (curcumin diethyl disuccinate); 106392-12-5 (Poloxamer); 9012-76-4 (Chitosan); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6105


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[PMID]:27773789
[Au] Autor:Mkrtchyan G; Graf A; Bettendorff L; Bunik V
[Ad] Endereço:Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Leninskije gori 1, 119992 Moscow, Russia.
[Ti] Título:Cellular thiamine status is coupled to function of mitochondrial 2-oxoglutarate dehydrogenase.
[So] Source:Neurochem Int;101:66-75, 2016 12.
[Is] ISSN:1872-9754
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Decreased thiamine and reduced activity of thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase (OGDH) cause neurodegeneration. We hypothesized on concerted cell-specific regulation of the thiamine metabolism and ThDP-dependent reactions. We identified a smaller thiamine pool, a lower expression of the mitochondrial ThDP transporter, and a higher expression of OGDH in rat astrocytes versus neuroblastoma N2A. According to the data, the astrocytic OGDH may be up-regulated by an increase in intracellular ThDP, while the neuroblastomal OGDH functions at full ThDP saturation. Indeed, in rat astrocytes and brain cortex, OGDH inhibition by succinyl phosphonate (SP) enlarged the pool of thiamine compounds. Increased ThDP level in response to the OGDH inhibition presumably up-regulated the enzyme to compensate for a decrease in reducing power which occurred in SP-treated astrocytes. Under the same SP treatment of N2A cells, their thiamine pool and reducing power were unchanged, although SP action was evident from accumulation of glutamate. The presented data indicate that functional interplay between OGDH, other proteins of the tricarbocylic acid cycle and proteins of thiamine metabolism is an important determinant of physiology-specific networks and their homeostatic mechanisms.
[Mh] Termos MeSH primário: Córtex Cerebral/efeitos dos fármacos
Complexo Cetoglutarato Desidrogenase/metabolismo
Mitocôndrias/efeitos dos fármacos
Tiamina/metabolismo
[Mh] Termos MeSH secundário: Animais
Córtex Cerebral/metabolismo
Citoplasma/metabolismo
Ácido Glutâmico/metabolismo
Homeostase/efeitos dos fármacos
Homeostase/fisiologia
Camundongos
Mitocôndrias/metabolismo
Organofosfonatos/metabolismo
Organofosfonatos/farmacologia
Succinatos/metabolismo
Succinatos/farmacologia
Tiamina Pirofosfato/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Organophosphonates); 0 (Succinates); 0 (succinyl phosphonate); 3KX376GY7L (Glutamic Acid); EC 1.2.4.2 (Ketoglutarate Dehydrogenase Complex); Q57971654Y (Thiamine Pyrophosphate); X66NSO3N35 (Thiamine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:29244925
[Au] Autor:Zadnipryanyy IV; Tretiakova OS; Sataieva TP
[Ti] Título:Cardio and cytoprotective effect of cytoflavin in terms of experimental perinatal hemic hypoxia.
[So] Source:Patol Fiziol Eksp Ter;60(4):64-71, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose: The purpose of research is to study cardiocytoprotective effect of cytoflavin in terms of aperinatal hypoxia in experiment. Methods: During research the offspring (22 pups) of 15 females of white Wistar line rats aged 3-4 months were involved. The hypoxia was recreated by daily intraperitoneal introduction of sodium nitrite (NaNO2) in a dose of 5 mg/100 g of the body weight causing a moderately severe hypoxia. To females of the first group, and also their posterity medicamental correction wasn't carried out. To females of the second group (8 females) after administration of sodium nitrite Cytoflavin was injected intraperitoneally. For an assessment of consequences of a perinatal hypoxia pups aged 7 days were slaughtered by means of a fast decapitation under ethereal anesthesia. Results: It is taped that the hypoxia induced by nitrobonds has the expressed damaging effect on cardiomyocytes of newborn infant rats which is shown in the form of the hypoxemic and ischemic changes caused, first of all, by disturbance of integrity of cellular and mitochondrial membranes causes formation of hypoxemic type of a metabolism in a cardiac muscle, disturbance of energy balance in it found reflection in disturbance of automatism of a myocardium of experimental animals. Cytoflavin at pregnant females in experiment allows to lower a damage rate of cardiomyocytes at newborn animals, first of all, at the expense of his protective properties. Conclusion: Membrane-protective properties of the drug along with its anti-hypoxic and antioxidant effects can put Cytoflavin in a number of promising drugs with cardiological and cytological protective action, leading to the optimization of energy metabolism in ischemic myocardium and allows it to take its rightful place among the modern drugs which are used to correct disorders of energy metabolism in the ischemic myocardium including pathologies in the neonatal period.
[Mh] Termos MeSH primário: Cardiotônicos/farmacologia
Mononucleotídeo de Flavina/farmacologia
Hipóxia
Inosina Difosfato/farmacologia
Miocárdio
Miócitos Cardíacos
Niacinamida/farmacologia
Succinatos/farmacologia
[Mh] Termos MeSH secundário: Animais
Combinação de Medicamentos
Feminino
Hipóxia/induzido quimicamente
Hipóxia/tratamento farmacológico
Hipóxia/metabolismo
Hipóxia/patologia
Masculino
Miocárdio/metabolismo
Miocárdio/patologia
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/patologia
Ratos
Ratos Wistar
Nitrito de Sódio/efeitos adversos
Nitrito de Sódio/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 0 (Drug Combinations); 0 (Succinates); 0 (cytoflavin); 25X51I8RD4 (Niacinamide); 7N464URE7E (Flavin Mononucleotide); 86-04-4 (Inosine Diphosphate); M0KG633D4F (Sodium Nitrite)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:29244923
[Au] Autor:Valeev VV; Trashkov; Kovaleko AL; Petrov AU; Vasiliev AG
[Ti] Título:Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity.
[So] Source:Patol Fiziol Eksp Ter;60(4):52-7, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.
[Mh] Termos MeSH primário: Arginina/farmacologia
Cardiomiopatias
Doxorrubicina/efeitos adversos
Succinatos/farmacologia
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Cardiomiopatias/induzido quimicamente
Cardiomiopatias/prevenção & controle
Cardiotoxicidade/tratamento farmacológico
Doxorrubicina/farmacologia
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Succinates); 0 (Vasodilator Agents); 80168379AG (Doxorubicin); 94ZLA3W45F (Arginine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:28832260
[Au] Autor:Davoudi Z; Rabiee M; Houshmand B; Eslahi N; Khoshroo K; Rasoulianboroujeni M; Tahriri M; Tayebi L
[Ad] Endereço:a Biomaterials Group, Faculty of Biomedical Engineering , Amirkabir University of Technology , Tehran , Iran.
[Ti] Título:Development of chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis.
[So] Source:Drug Dev Ind Pharm;44(1):40-55, 2018 Jan.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this research was to develop chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate as a buccal mucoadhesive patch to treat desquamative gingivitis, which was fabricated through an environmental friendly process. Mucoadhesive films increase the advantage of higher efficiency and drug localization in the affected region. In this research, mucoadhesive films, for the release of hydrocortisone sodium succinate, were prepared using different ratios of chitosan, gelatin and keratin. In the first step, chitosan and gelatin proportions were optimized after evaluating the mechanical properties, swelling capacity, water uptake, stability, and biodegradation of the films. Then, keratin was added at different percentages to the optimum composite of chitosan and gelatin together with the drug. The results of surface pH showed that none of the samples were harmful to the buccal cavity. FTIR analysis confirmed the influence of keratin on the structure of the composite. The presence of a higher amount of keratin in the composite films resulted in high mechanical, mucoadhesive properties and stability, low water uptake and biodegradation in phosphate buffer saline (pH = 7.4) containing 10 U/ml lysozyme. The release profile of the films ascertained that keratin is a rate controller in the release of the hydrocortisone sodium succinate. Finally, chitosan/gelatin/keratin composite containing hydrocortisone sodium succinate can be employed in dental applications.
[Mh] Termos MeSH primário: Quitosana/química
Gelatina/química
Gengivite/tratamento farmacológico
Hidrocortisona/análogos & derivados
Hidrocortisona/química
Queratinas/química
Succinatos/química
[Mh] Termos MeSH secundário: Adesividade
Hidrocortisona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Succinates); 68238-35-7 (Keratins); 9000-70-8 (Gelatin); 9012-76-4 (Chitosan); LIU00Z1Z84 (cortisol succinate); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1371738


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[PMID]:28452034
[Au] Autor:Fang L; Wang M; Cai L; Cang L
[Ad] Endereço:State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A&F University, Yangling, 712100, China.
[Ti] Título:Deciphering biodegradable chelant-enhanced phytoremediation through microbes and nitrogen transformation in contaminated soils.
[So] Source:Environ Sci Pollut Res Int;24(17):14627-14636, 2017 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Biodegradable chelant-enhanced phytoremediation offers an alternative treatment technique for metal contaminated soils, but most studies to date have addressed on phytoextraction efficiency rather than comprehensive understanding of the interactions among plant, soil microbes, and biodegradable chelants. In the present study, we investigated the impacts of biodegradable chelants, including nitrilotriacetate, S,S-ethylenediaminedisuccinic acid (EDDS), and citric acid on soil microbes, nitrogen transformation, and metal removal from contaminated soils. The EDDS addition to soil showed the strongest ability to promote the nitrogen cycling in soil, ryegrass tissue, and microbial metabolism in comparison with other chelants. Both bacterial community-level physiological profiles and soil mass specific heat rates demonstrated that soil microbial activity was inhibited after the EDDS application (between day 2 and 10), but this effect completely vanished on day 30, indicating the revitalization of microbial activity and community structure in the soil system. The results of quantitative real-time PCR revealed that the EDDS application stimulated denitrification in soil by increasing nitrite reductase genes, especially nirS. These new findings demonstrated that the nitrogen release capacity of biodegradable chelants plays an important role in accelerating nitrogen transformation, enhancing soil microbial structure and activity, and improving phytoextraction efficiency in contaminated soil.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Quelantes
Etilenodiaminas
Nitrogênio/metabolismo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Solo
Succinatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Ethylenediamines); 0 (Soil); 0 (Soil Pollutants); 0 (Succinates); N762921K75 (Nitrogen)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-9029-y


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[PMID]:28745667
[Au] Autor:Novikov AY; Kovalev VA; Vinichuk NV; Chernyh YA; Golub IE; Sorokina LV
[Ad] Endereço:Primorye regional clinical hospital #1, Vladivostok, Russia.
[Ti] Título:[Prevention and correction of cognitive dysfunction after general anesthesia].
[Ti] Título:Profilaktika i korrektsiia kognitivnykh narushenii posle obshchei anestezii..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):28-31, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate clinical efficacy of intraoperative use of cytoflavin in the prevention and correction of cognitive functions in surgical patients with no history of neurological and psychosomatic disorders. MATERIAL AND METHODS: The study included 60 female patients who underwent surgery on the thyroid gland. Patients were stratified into two equal groups matched for main indices. Patients of the main group received infusions of cytoflavin (20 ml in 200 ml of 5% glucose solution). Patients underwent thyroidectomy with general inhalation anesthesia using desflurane. Cognitive testing was performed one day before operation and 6, 24 and 48 h after. Waking time after stopping desflurane administration and time prior tracheal extubation were recorded. RESULTS AND CONCLUSION: The use of cytoflavin promoted the early post anesthesia adaptation and more rapid recovery of initial cognitive status of the patients.
[Mh] Termos MeSH primário: Período de Recuperação da Anestesia
Anestesia por Inalação/efeitos adversos
Anestésicos Inalatórios/efeitos adversos
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/prevenção & controle
Mononucleotídeo de Flavina/uso terapêutico
Inosina Difosfato/uso terapêutico
Niacinamida/uso terapêutico
Succinatos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Anestésicos Inalatórios/administração & dosagem
Combinação de Medicamentos
Feminino
Seres Humanos
Cuidados Intraoperatórios
Isoflurano/administração & dosagem
Isoflurano/efeitos adversos
Isoflurano/análogos & derivados
Meia-Idade
Doenças da Glândula Tireoide/cirurgia
Tireoidectomia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Drug Combinations); 0 (Succinates); 0 (cytoflavin); 25X51I8RD4 (Niacinamide); 7N464URE7E (Flavin Mononucleotide); 86-04-4 (Inosine Diphosphate); CRS35BZ94Q (desflurane); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171176128-31


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[PMID]:28836855
[Au] Autor:Chamsai B; Limmatvapirat S; Sungthongjeen S; Sriamornsak P
[Ad] Endereço:a Department of Pharmaceutical Technology, Faculty of Pharmacy , Silpakorn University , Nakhon Pathom , Thailand.
[Ti] Título:Enhancement of solubility and oral bioavailability of manidipine by formation of ternary solid dispersion with d-α-tocopherol polyethylene glycol 1000 succinate and copovidone.
[So] Source:Drug Dev Ind Pharm;43(12):2064-2075, 2017 Dec.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Low bioavailability of oral manidipine (MDP) is due to its low water solubility. OBJECTIVE: The objective of this study was to increase the solubility and bioavailability of MDP by fabricating ternary solid dispersion (tSD) with d-α-tocopherol polyethyleneglycol-1000-succinate and copovidone. METHODS: In this study, solid ternary phase diagram was applied in order to check the homogeneity of tSD prepared by melting and solidifying with dry ice. The physicochemical properties of different formulations were determined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and hot stage microscopy. Their solubility, dissolution, stability and bioavailability were also investigated. RESULTS AND DISCUSSION: The results demonstrated that tSD obtained from ternary phase diagram divided into homogeneous and non-homogeneous regions. In the homogenous region, the transparent characteristics of tSD was observed and considered as a glass solution, which have a higher MDP solubility than that in non-homogenous region. The hot stage microscopy, DSC and PXRD confirmed that solid dispersion was formed in which MDP was molecularly dispersed in the carriers, especially in the homogenous region of phase diagram. FTIR analysis demonstrated strong hydrogen bonding between amine groups of MDP and carbonyl groups of copovidone, which supported a higher solubility and dissolution of tSD. The pharmacokinetic study in Wistar rats showed that the tSD had the greatest effect on oral bioavailability. Immediate hypotensive effect of tSD was also observed in vivo. CONCLUSIONS: The improvement of stability, dissolution and oral bioavailability of MDP could be achieved by using tSD technique.
[Mh] Termos MeSH primário: Di-Hidropiridinas/química
Di-Hidropiridinas/farmacocinética
Polietilenoglicóis/química
Pirrolidinas/química
Succinatos/química
Compostos de Vinila/química
alfa-Tocoferol/química
alfa-Tocoferol/farmacocinética
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Varredura Diferencial de Calorimetria
Pós
Ratos
Ratos Wistar
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dihydropyridines); 0 (Powders); 0 (Pyrrolidines); 0 (Succinates); 0 (Vinyl Compounds); 0 (poly(vinylpyrrolidone-co-vinyl-acetate)); 30IQX730WE (Polyethylene Glycols); 6O4754US88 (manidipine); H4N855PNZ1 (alpha-Tocopherol); U076Q6Q621 (polyethylene glycol 1000)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1371731


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[PMID]:28806652
[Au] Autor:Race M
[Ad] Endereço:Dipartimento di Ingegneria Civile, Edile ed Ambientale, Università di Napoli Federico II, 80125 Napoli, Italy. Electronic address: marco.race@unina.it.
[Ti] Título:Applicability of alkaline precipitation for the recovery of EDDS spent solution.
[So] Source:J Environ Manage;203(Pt 1):358-363, 2017 Dec 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper presents an innovative procedure for the recovery of SS-ethylenediamine-N,N'-disuccinic acid (EDDS) solution used for soil washing processes. The procedure is derived from that applied for the recovery of ethylenediamine-tetraacetic acid (EDTA), modifying and optimizing the choice of the chemical agents used for the protonation of the chelant, the exchange of the metals, and the final precipitation of the unwanted compounds. To select the reagents and test the proposed approach, an experimental study was conducted on real EDDS spent solutions, obtained washing a Cu and Zn real contaminated soil. According to the results obtained, the precipitation ranges from 30% to more than 90% for both Cu and Zn, depending on the adopted reagent sequence, and on the molar ratio between the salt and the chelant contained in the spent solution. Data were in agreement with chemical equilibrium predicted in ideal conditions. The recovered solutions had a reduced ability to remove the contaminants when applied in a new soil washing cycle (15% less for Cu and 30% less for Zn) because of the high concentration of alkaline metal ions required for the precipitation. At the same time, they were more biodegradable compared to non-treated solutions, confirming that EDDS-metal chelates may represent a threat for biological wastewater processes.
[Mh] Termos MeSH primário: Etilenodiaminas/química
Poluentes do Solo
Succinatos/química
[Mh] Termos MeSH secundário: Quelantes
Ácido Edético
Metais Pesados
Águas Residuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Ethylenediamines); 0 (Metals, Heavy); 0 (Soil Pollutants); 0 (Succinates); 0 (Waste Water); 20846-91-7 (N,N'-ethylenediamine disuccinic acid); 9G34HU7RV0 (Edetic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


  10 / 9532 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28678947
[Au] Autor:Gomes RS; Souza CMC; Bergamo ETP; Bordin D; Del Bel Cury AA
[Ad] Endereço:Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Departamento de Prótese e Periodontia, Piracicaba, SP, Brasil.
[Ti] Título:Misfit and fracture load of implant-supported monolithic crowns in zirconia-reinforced lithium silicate.
[So] Source:J Appl Oral Sci;25(3):282-289, 2017 May-Jun.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: In this study, marginal and internal misfit and fracture load with and without thermal-mechanical aging (TMA) of monolithic ZLS and lithium disilicate (LDS) crowns were evaluated. Material and methods: Crowns were milled using a computer-aided design/computer-aided manufacturing system. Marginal gaps (MGs), absolute marginal discrepancy (AMD), axial gaps, and occlusal gaps were measured by X-ray microtomography (n=8). For fracture load testing, crowns were cemented in a universal abutment, and divided into four groups: ZLS without TMA, ZLS with TMA, LDS without TMA, and LDS with TMA (n=10). TMA groups were subjected to 10,000 thermal cycles (5-55°C) and 1,000,000 mechanical cycles (200 N, 3.8 Hz). All groups were subjected to compressive strength testing in a universal testing machine at a crosshead speed of 1 mm/min until failure. Student's t-test was used to examine misfit, two-way analysis of variance was used to analyze fracture load, and Pearson's correlation coefficients for misfit and fracture load were calculated (α=0.05). The materials were analyzed according to Weibull distribution, with 95% confidence intervals. Results: Average MG (p<0.001) and AMD (p=0.003) values were greater in ZLS than in LDS crowns. TMA did not affect the fracture load of either material. However, fracture loads of ZLS crowns were lower than those of LDS crowns (p<0.001). Fracture load was moderately correlated with MG (r=-0.553) and AMD (r=-0.497). ZLS with TMA was least reliable, according to Weibull probability. Conclusion: Within the limitations of this study, ZLS crowns had lower fracture load values and greater marginal misfit than did LDS crowns, although these values were within acceptable limits.
[Mh] Termos MeSH primário: Coroas
Adaptação Marginal Dentária
Prótese Dentária Fixada por Implante/métodos
Falha de Restauração Dentária
Compostos Organometálicos/química
Succinatos/química
Zircônio/química
[Mh] Termos MeSH secundário: Análise de Variância
Força Compressiva
Projeto Auxiliado por Computador
Planejamento de Prótese Dentária
Teste de Materiais
Valores de Referência
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Propriedades de Superfície
Fatores de Tempo
Fraturas dos Dentes
Microtomografia por Raio-X
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 0 (Succinates); C6V6S92N3C (Zirconium); MD64P82Y28 (lithium succinate); S38N85C5G0 (zirconium oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE



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