Base de dados : MEDLINE
Pesquisa : D02.241.081.337.759.500 [Categoria DeCS]
Referências encontradas : 1515 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 152 ir para página                         

  1 / 1515 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28220909
[Au] Autor:Xie Y; Zhou G
[Ad] Endereço:Hunan Normal University, Changsha, China (College of Medicine, Department of Preventive Medicine). lilac0408@sina.com.
[Ti] Título:Effects of meso-2,3-dimercaptosuccinic acid, potassium iodide and chlorophyll on lead accumulation in male mice.
[So] Source:Int J Occup Med Environ Health;30(1):87-93, 2017 Feb 21.
[Is] ISSN:1896-494X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Lead (Pb) pollution is a serious public health problem all over the world, it especially plays severe damage role in children's health. Apart from reducing lead-induced damages, the decrease of lead accumulation is also critical. This study has been the first attempt to investigate effects of meso-2,3-dimercaptosuccinic acid (DMSA), potassium iodide (KI) and chlorophyll (Chl) on lead accumulation in male mice. MATERIAL AND METHODS: Eighty healthy Kunming male mice were selected and divided randomly into 8 groups. They were treated with lead acetate (PbAc) intraperitoneally, individually and in combination with the DMSA, KI or Chl once daily for 5 days. Meanwhile, the control group was treated with normal saline during the whole exposure period. On 30th day, mice were sacrificed and lead concentrations were detected in the whole blood, livers, kidneys, and testicles of mice by means of the graphite furnace atomic absorption spectrometry. RESULTS: In comparison with the control group, lead concentrations increased in mice treated with the PbAc and DMSA, KI and Chl diminished lead accumulation in the whole blood, livers, and kidneys. Chl had specifically the same effects on lead concentrations in the testicles of male mice. CONCLUSIONS: Potassium iodide and Chl, as food additives, had the same effects as the DMSA to reduce lead accumulation in male mice effectively. Our results provided experimental evidence in vivo for the preventive measures of lead poisoning. Int J Occup Med Environ Health 2017;30(1):87-93.
[Mh] Termos MeSH primário: Quelantes/uso terapêutico
Clorofila/uso terapêutico
Intoxicação por Chumbo/tratamento farmacológico
Iodeto de Potássio/uso terapêutico
Succímero/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Aditivos Alimentares
Rim/química
Chumbo/análise
Chumbo/sangue
Intoxicação por Chumbo/metabolismo
Intoxicação por Chumbo/prevenção & controle
Fígado/química
Masculino
Camundongos
Testículo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Food Additives); 1406-65-1 (Chlorophyll); 1C4QK22F9J (Potassium Iodide); 2P299V784P (Lead); DX1U2629QE (Succimer)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE


  2 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28115250
[Au] Autor:Xiang Y; Bai Z; Zhang S; Sun Y; Wang S; Wei X; Mo W; Long J; Liu Z; Yang C; Zheng L; Guo X; Xiaoyang W; Mao F; Feng N
[Ad] Endereço:Urology Surgery of Haikou People's Hospital, Haikou, China.
[Ti] Título:Lead adsorption, anticoagulation and in vivo toxicity studies on the new magnetic nanomaterial Fe O @SiO @DMSA as a hemoperfusion adsorbent.
[So] Source:Nanomedicine;13(4):1341-1351, 2017 May.
[Is] ISSN:1549-9642
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This project aimed to develop and characterize a new nanoadsorbent for hemoperfusion. Fe O nanoparticles synthesized by a facile solvothermal method were coated with S O and further modified by DMSA. TEM, XRD, FTIR, XPS and SEM were performed before and after lead adsorption to reveal the general performance and adsorption mechanism. Rabbit lead poisoning models were established to study the adsorption rate; then, a pig hemoperfusion experiment was used for further validation. In addition, coagulation, liver, kidney and heart function, blood lipids, electrolytes and the immune inflammatory system were studied before and after hemoperfusion. The results indicated that the materials had a high adsorption rate and chemisorbed lead mainly in the plasma. No obvious coagulation-fibrinolysis, organ toxicity, electrolyte disturbances, inflammatory reactions or immunosuppression was observed. The excellent blood compatibility and high biosafety of this material demonstrate its potential as a new type of hemoperfusion adsorbent.
[Mh] Termos MeSH primário: Óxido Ferroso-Férrico/química
Hemoperfusão
Intoxicação por Chumbo/terapia
Chumbo/química
Nanopartículas/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Teste de Materiais
Coelhos
Dióxido de Silício/química
Succímero/química
Suínos
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2P299V784P (Lead); 7631-86-9 (Silicon Dioxide); DX1U2629QE (Succimer); XM0M87F357 (Ferrosoferric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


  3 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27919185
[Au] Autor:van Eijkeren JC; Olie JD; Bradberry SM; Vale JA; de Vries I; Clewell HJ; Meulenbelt J; Hunault CC
[Ad] Endereço:a National Institute for Public Health and the Environment , Bilthoven , The Netherlands.
[Ti] Título:Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead.
[So] Source:Clin Toxicol (Phila);55(2):133-141, 2017 Feb.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of chelation in lead poisoning. Our aim was to devise a model to predict the effect of succimer (dimercaptosuccinic acid; DMSA) chelation therapy on blood lead concentrations. MATERIALS AND METHODS: We integrated a two-compartment kinetic succimer model into an existing PBPK lead model and produced a Chelation Lead Therapy (CLT) model. The accuracy of the model's predictions was assessed by simulating clinical observations in patients poisoned by lead and treated with succimer. The CLT model calculates blood lead concentrations as the sum of the background exposure and the acute or chronic lead poisoning. The latter was due either to ingestion of traditional remedies or occupational exposure to lead-polluted ambient air. The exposure duration was known. The blood lead concentrations predicted by the CLT model were compared to the measured blood lead concentrations. RESULTS: Pre-chelation blood lead concentrations ranged between 99 and 150 µg/dL. The model was able to simulate accurately the blood lead concentrations during and after succimer treatment. The pattern of urine lead excretion was successfully predicted in some patients, while poorly predicted in others. CONCLUSIONS: Our model is able to predict blood lead concentrations after succimer therapy, at least, in situations where the duration of lead exposure is known.
[Mh] Termos MeSH primário: Quelantes/uso terapêutico
Intoxicação por Chumbo/tratamento farmacológico
Modelos Biológicos
Succímero/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antídotos/uso terapêutico
Terapia por Quelação/métodos
Seres Humanos
Chumbo/sangue
Chumbo/urina
Intoxicação por Chumbo/etiologia
Masculino
Medicina Tradicional/efeitos adversos
Exposição Ocupacional/efeitos adversos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Chelating Agents); 2P299V784P (Lead); DX1U2629QE (Succimer)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2016.1263855


  4 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27916642
[Au] Autor:Oh Y; Moorthy MS; Manivasagan P; Bharathiraja S; Oh J
[Ad] Endereço:Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, South Korea.
[Ti] Título:Magnetic hyperthermia and pH-responsive effective drug delivery to the sub-cellular level of human breast cancer cells by modified CoFe O nanoparticles.
[So] Source:Biochimie;133:7-19, 2017 Feb.
[Is] ISSN:1638-6183
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Magnetic iron oxide nanoparticles (MNPs) have been extensively utilized in a wide range of biomedical applications including magnetic hyperthermia agent. To improve the efficiency of the MNPs in therapeutic applications, in this study, we have synthesized CoFe O nanoparticles and its surface was further functionalized with meso-2,3-dimercaptosuccinic acid (DMSA). The anticancer agent, Doxorubucin (DOX) was conjugated with CoFe O @DMSA nanoparticle to evaluate the combined effects of thermotherapy and chemotherapy. The drug delivery efficiency of the DOX loaded CoFe O @DMSA nanoparticles were examined based on magnetically triggered delivery of DOX into the subcellular level of cancer cells by using MDA-MB-231 cell line. The amine part of the DOX molecules were effectively attached through an electrostatic interactions and/or hydrogen bonding interactions with the carboxylic acid groups of the DMSA functionalities present onto the surface of the CoFe O nanoparticles. The DOX loaded CoFe O @DMSA nanoparticles can effectively uptake with cancer cells via typical endocytosis process. After endocytosis, DOX release from CoFe O nanoparticles was triggered by intracellular endosomal/lysosomal acidic environments and the localized heat can be generated under an alternating magnetic field (AMF). In the presence of AMF, the released DOX molecules were accumulated with high concentrations into the subcellular level at a desired sites and exhibited a synergistic effect of an enhanced cell cytotoxicity by the combined effects of thermal-chemotherapy. Importantly, pH- and thermal-responsive Dox-loaded CoFe O nanoparticles induced significant cellular apoptosis more efficiently mediated by active mitochondrial membrane and ROS generation than the free Dox. Thus, the Dox-loaded CoFe O @DMSA nanoparticles can be used as a potential therapeutic agent in cancer therapy by combining the thermo-chemotherapy techniques.
[Mh] Termos MeSH primário: Neoplasias da Mama/tratamento farmacológico
Doxorrubicina/administração & dosagem
Sistemas de Liberação de Medicamentos
Nanopartículas de Magnetita/administração & dosagem
[Mh] Termos MeSH secundário: Neoplasias da Mama/patologia
Linhagem Celular Tumoral
Cobalto/química
Doxorrubicina/química
Endocitose/efeitos dos fármacos
Feminino
Compostos Férricos/química
Seres Humanos
Concentração de Íons de Hidrogênio
Hipertermia Induzida
Campos Magnéticos
Nanopartículas de Magnetita/química
Succímero/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Magnetite Nanoparticles); 1K09F3G675 (ferric oxide); 3G0H8C9362 (Cobalt); 80168379AG (Doxorubicin); DX1U2629QE (Succimer)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


  5 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27799742
[Au] Autor:Abu El-Saad AM; Al-Kahtani MA; Abdel-Moneim AM
[Ad] Endereço:Department of Biology, Faculty of Medicine, Dammam University, Dammam, Saudi Arabia; Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.
[Ti] Título:N-acetylcysteine and meso-2,3-dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats.
[So] Source:Drug Des Devel Ther;10:3425-3434, 2016.
[Is] ISSN:1177-8881
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Environmental exposure to arsenic represents a serious challenge to humans and other animals. The aim of the present study was to test the protective effect of antioxidant N-acetylcysteine (NAC) either individually or in combination with a chelating agent, meso-2,3-dimercaptosuccinic acid (DMSA), against sodium arsenite oral toxicity in male rats. Five groups were used: control; arsenic group (orally administrated in a concentration of 2 mg/kg body weight [b.w.]); the other three groups were orally administrated sodium arsenite in a concentration of 2 mg/kg b.w. followed by either NAC (10 mg/kg b.w., intraperitoneally [i.p.]), DMSA (50 mg/kg b.w., i.p.) or NAC plus DMSA. Arsenic toxicity caused significant rise in serum aspartate aminotransferase, alanine aminotransferase and total bilirubin, and a significant decrease in total protein (TP) and albumin levels after 3 weeks of experimental period. In addition, arsenic-treated rats showed significantly higher arsenic content in liver and significant rise in hepatic malondialdehyde level. By contrast, sharp decreases in glutathione content and catalase and glutathione reductase activities were discernible. NAC and/or DMSA counteracted most of these physiologic and biochemical defects. NAC monotherapy was more effective than DMSA in increasing TP, while DMSA was more effective in decreasing alanine aminotransferase. The combined treatment was superior over monotherapies in recovery of TP and glutathione. Biochemical data were well supported by histopathological and ultrastructural findings. In conclusion, the combination therapy of NAC and DMSA may be an ideal choice against oxidative insult induced by arsenic poisoning.
[Mh] Termos MeSH primário: Acetilcisteína/farmacologia
Acetilcisteína/uso terapêutico
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia
Estresse Oxidativo/efeitos dos fármacos
Succímero/farmacologia
Succímero/uso terapêutico
[Mh] Termos MeSH secundário: Acetilcisteína/administração & dosagem
Animais
Arsenitos/administração & dosagem
Arsenitos/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Masculino
Ratos
Ratos Wistar
Compostos de Sódio/administração & dosagem
Compostos de Sódio/toxicidade
Succímero/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenites); 0 (Sodium Compounds); 48OVY2OC72 (sodium arsenite); DX1U2629QE (Succimer); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE


  6 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27793866
[Au] Autor:Zellner T; Zellner N; Felgenhauer N; Eyer F
[Ad] Endereço:Department for Clinical Toxicology, Klinikum rechts der Isar-School of Medicine, Technical University of Munich, Munich, Germany.
[Ti] Título:Dementia, epilepsy and polyneuropathy in a mercury-exposed patient: investigation, identification of an obscure source and treatment.
[So] Source:BMJ Case Rep;2016, 2016 Oct 28.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present a patient aged 54 years with early onset of dementia, epilepsy and peripheral polyneuropathy. A mercury intoxication was diagnosed in 2010, chelation therapy with 2,3-dimercaptopropane-1-sulfonate had failed. A source of exposure could not be identified. MRI showed unspecific hyperintense brain lesions in 2015. She was referred for diagnosis and treatment. Neuropsychological testing indicated severe memory loss and nerve conduction speed measurements showed chronic neurogenically changed potentials. Mercury levels in blood and urine and neuron-specific enolase (NSE) were elevated. A detailed patient history revealed a daily application of mercury-containing skin lightening creams for 6 years. Treatment with 2,3-dimercaptosuccinic acid (DMSA) was started, blood mercury levels were falling during treatment. She was discharged with DMSA prescriptions. A renewed MRI revealed unchanged brain lesions. Blood and urine mercury levels and NSE were falling. Memory function had improved qualitatively and quantitatively.
[Mh] Termos MeSH primário: Demência/induzido quimicamente
Epilepsia/induzido quimicamente
Intoxicação por Mercúrio/etiologia
Polineuropatias/induzido quimicamente
Creme para a Pele/efeitos adversos
[Mh] Termos MeSH secundário: Quelantes/uso terapêutico
Feminino
Seres Humanos
Mercúrio/análise
Intoxicação por Mercúrio/tratamento farmacológico
Meia-Idade
Creme para a Pele/química
Succímero/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); DX1U2629QE (Succimer); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  7 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27710180
[Au] Autor:van Eijkeren JC; Olie JD; Bradberry SM; Vale JA; de Vries I; Meulenbelt J; Hunault CC
[Ad] Endereço:a National Institute for Public Health and the Environment , Bilthoven , The Netherlands.
[Ti] Título:Modelling dimercaptosuccinic acid (DMSA) plasma kinetics in humans.
[So] Source:Clin Toxicol (Phila);54(9):833-839, 2016 Nov.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: No kinetic models presently exist which simulate the effect of chelation therapy on lead blood concentrations in lead poisoning. OBJECTIVE: Our aim was to develop a kinetic model that describes the kinetics of dimercaptosuccinic acid (DMSA; succimer), a commonly used chelating agent, that could be used in developing a lead chelating model. MATERIAL AND METHODS: This was a kinetic modelling study. We used a two-compartment model, with a non-systemic gastrointestinal compartment (gut lumen) and the whole body as one systemic compartment. The only data available from the literature were used to calibrate the unknown model parameters. The calibrated model was then validated by comparing its predictions with measured data from three different experimental human studies. RESULTS: The model predicted total DMSA plasma and urine concentrations measured in three healthy volunteers after ingestion of DMSA 10 mg/kg. The model was then validated by using data from three other published studies; it predicted concentrations within a factor of two, representing inter-human variability. CONCLUSIONS: A simple kinetic model simulating the kinetics of DMSA in humans has been developed and validated. The interest of this model lies in the future potential to use it to predict blood lead concentrations in lead-poisoned patients treated with DMSA.
[Mh] Termos MeSH primário: Quelantes/farmacocinética
Intoxicação por Chumbo/tratamento farmacológico
Modelos Biológicos
Succímero/farmacocinética
[Mh] Termos MeSH secundário: Adulto
Terapia por Quelação/métodos
Seres Humanos
Chumbo/sangue
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Chelating Agents); 2P299V784P (Lead); DX1U2629QE (Succimer)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE


  8 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27431051
[Au] Autor:Silva LH; da Silva JR; Ferreira GA; Silva RC; Lima EC; Azevedo RB; Oliveira DM
[Ad] Endereço:IB-Departamento de Genética e Morfologia, Universidade de Brasília-UNB, Campus Universitário Darcy Ribeiro-Asa Norte, Brasília, DF, CEP 70910-970, Brazil.
[Ti] Título:Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles: assessment of biocompatibility and potential applications.
[So] Source:J Nanobiotechnology;14(1):59, 2016 Jul 18.
[Is] ISSN:1477-3155
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nanoparticles' unique features have been highly explored in cellular therapies. However, nanoparticles can be cytotoxic. The cytotoxicity can be overcome by coating the nanoparticles with an appropriated surface modification. Nanoparticle coating influences biocompatibility between nanoparticles and cells and may affect some cell properties. Here, we evaluated the biocompatibility of gold and maghemite nanoparticles functionalized with 2,3-dimercaptosuccinic acid (DMSA), Au-DMSA and γ-Fe2O3-DMSA respectively, with human mesenchymal stem cells. Also, we tested these nanoparticles as tracers for mesenchymal stem cells in vivo tracking by computed tomography and as agents for mesenchymal stem cells magnetic targeting. RESULTS: Significant cell death was not observed in MTT, Trypan Blue and light microscopy analyses. However, ultra-structural alterations as swollen and degenerated mitochondria, high amounts of myelin figures and structures similar to apoptotic bodies were detected in some mesenchymal stem cells. Au-DMSA and γ-Fe2O3-DMSA labeling did not affect mesenchymal stem cells adipogenesis and osteogenesis differentiation, proliferation rates or lymphocyte suppression capability. The uptake measurements indicated that both inorganic nanoparticles were well uptaken by mesenchymal stem cells. However, Au-DMSA could not be detected in microtomograph after being incorporated by mesenchymal stem cells. γ-Fe2O3-DMSA labeled cells were magnetically responsive in vitro and after infused in vivo in an experimental model of lung silicosis. CONCLUSION: In terms of biocompatibility, the use of γ-Fe2O3-DMSA and Au-DMSA as tracers for mesenchymal stem cells was assured. However, Au-DMSA shown to be not suitable for visualization and tracking of these cells in vivo by standard computed microtomography. Otherwise, γ-Fe2O3-DMSA shows to be a promising agent for mesenchymal stem cells magnetic targeting.
[Mh] Termos MeSH primário: Rastreamento de Células/métodos
Nanopartículas de Magnetita/química
Células Mesenquimais Estromais/efeitos dos fármacos
Silicose/diagnóstico por imagem
Coloração e Rotulagem/métodos
Succímero/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Polpa Dentária/citologia
Polpa Dentária/efeitos dos fármacos
Compostos Férricos/química
Compostos Férricos/farmacologia
Ouro/química
Ouro/farmacologia
Seres Humanos
Nanopartículas de Magnetita/ultraestrutura
Células Mesenquimais Estromais/ultraestrutura
Camundongos
Camundongos Endogâmicos C57BL
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/ultraestrutura
Tamanho da Partícula
Cultura Primária de Células
Silicose/patologia
Succímero/química
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Magnetite Nanoparticles); 1K09F3G675 (ferric oxide); 7440-57-5 (Gold); DX1U2629QE (Succimer)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1186/s12951-016-0213-x


  9 / 1515 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27305822
[Au] Autor:Su T; Wang Y; Wang J; Han D; Ma S; Cao J; Li X; Zhang R; Qiao H; Liang J; Liu G; Yang B; Liang S; Nie Y; Wu K; Li J; Cao F
[Ti] Título:In Vivo Magnetic Resonance and Fluorescence Dual-Modality Imaging of Tumor Angiogenesis in Rats Using GEBP11 Peptide Targeted Magnetic Nanoparticles.
[So] Source:J Biomed Nanotechnol;12(5):1011-22, 2016 May.
[Is] ISSN:1550-7033
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Angiogenesis is an essential process for tumor progression. Tumor vasculature-targeting peptides have shown great potential for use in cancer imaging and therapy. Our previous studies have shown that GEBP11, a novel vasculature-specific binding peptide that exhibits high affinity and specificity to tumor angiogenesis, is a promising candidate for the diagnosis and targeted radiotherapy of gastric cancer. In the present study, we developed a novel magnetic resonance and fluorescence (MR/Fluo) dual-modality imaging probe by covalently coupling 2,3-dimercaptosuccinnic acid-coated paramagnetic nanoparticles (DMSA-MNPs) and Cy5.5 to the GEBP11 peptide. The probe Cy5.5-GEBP11-DMSA-MNPs (CGD-MNPs), with a hydrodynamic diameter of 82.8 ± 6.5 nm, exhibited good imaging properties, high stability and little cytotoxicity. In vivo MR/Fluo imaging revealed that CGD-MNPs were successfully applied to visualize tumor angiogenesis in SGC-7901 xenograft mouse models. Prussian blue and CD31 immunohistochemical staining confirmed that CGD-MNPs co-localized with tumor blood vessels. In conclusion, CGD-MNPs are promising candidates for use as MR and fluorescence imaging probes for visualizing gastric cancer angiogenesis in vivo.
[Mh] Termos MeSH primário: Diagnóstico por Imagem
Imagem por Ressonância Magnética
Nanopartículas de Magnetita/química
Neoplasias/irrigação sanguínea
Neovascularização Patológica/diagnóstico
Peptídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Carbocianinas/metabolismo
Morte Celular/efeitos dos fármacos
Endocitose/efeitos dos fármacos
Fluorescência
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/metabolismo
Seres Humanos
Espectroscopia de Ressonância Magnética
Nanopartículas de Magnetita/toxicidade
Nanopartículas de Magnetita/ultraestrutura
Camundongos Nus
Neoplasias/patologia
Ratos
Succímero/metabolismo
Distribuição Tecidual/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CY5.5 cyanine dye); 0 (Carbocyanines); 0 (GEBP11 peptide); 0 (Magnetite Nanoparticles); 0 (Peptides); DX1U2629QE (Succimer)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160616
[Lr] Data última revisão:
160616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE


  10 / 1515 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27280908
[Au] Autor:Paschali A; Tsiouris S
[Ad] Endereço:From the Nuclear Medicine Department, University Hospital of Ioannina, Ioannina, Greece.
[Ti] Título:Increased Background Activity in DMSA Scintigraphy of a Nonazotemic Patient With ß-Thalassemia Major.
[So] Source:Clin Nucl Med;41(9):714-5, 2016 Sep.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Renal DMSA uptake provides an index for evaluation of the functional tubular mass, which depends on the renal blood flow, proximal tubular cell membrane function, and urinary acid-base balance. We present a case of a nonazotemic 48-year-old adult with ß-thalassemia major under regular blood transfusions and iron chelation therapy that underwent DMSA scan showing minor cortical abnormalities and high background activity, featuring prominent cardiac blood pool and liver uptake. This case highlights the pitfall of high background activity during DMSA study in patients with ß-thalassemia major due to tubular disorders.
[Mh] Termos MeSH primário: Rim/diagnóstico por imagem
Cintilografia/métodos
Succímero/farmacocinética
Talassemia beta/diagnóstico por imagem
[Mh] Termos MeSH secundário: Seres Humanos
Meia-Idade
Talassemia beta/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
DX1U2629QE (Succimer)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170106
[Lr] Data última revisão:
170106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001270



página 1 de 152 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde