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[PMID]:28792968
[Au] Autor:Adams DJ; Nemkov TG; Mayer JP; Old WM; Stowell MHB
[Ad] Endereço:The Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America.
[Ti] Título:Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-ß42.
[So] Source:PLoS One;12(8):e0182804, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemistry. These synthetic methods can lead to minor impurities which can have profound effects on the biological activity of amyloid peptides. Here we used a combination of cytotoxicity assays, fibrillation assays and high resolution mass spectrometry (MS) to identify impurities in synthetic amyloid preparations that inhibit both cytotoxicity and aggregation. We identify the Aß42Δ39 species as the major peptide contaminant responsible for limiting both cytotoxicity and fibrillation of the amyloid peptide. In addition, we demonstrate that the presence of this minor impurity inhibits the formation of a stable Aß42 dimer observable by MS in very pure peptide samples. These results highlight the critical importance of purity and provenance of amyloid peptides in Alzheimer's research in particular, and biological research in general.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/química
Fragmentos de Peptídeos/química
[Mh] Termos MeSH secundário: Fluorenos
Ésteres do Ácido Fórmico
Seres Humanos
Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (9-fluorenylmethoxycarbonyl); 0 (Amyloid beta-Peptides); 0 (Fluorenes); 0 (Formic Acid Esters); 0 (Peptide Fragments); 0 (amyloid beta-protein (1-42)); 0 (t-butyloxycarbonyl group)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182804


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[PMID]:27986937
[Au] Autor:Yang J; Park Y; Hyun IH; Kim GH; Kim BS; Lee BH; Ren Y
[Ad] Endereço:Plant Quarantine Technology Center, Animal and Plant Quarantine Agency (QIA), Republic of Korea (joyang12@gmail.com; heroine1966@naver.com; ihhyun@korea.kr) joyang12@gmail.com.
[Ti] Título:A Combination Treatment Using Ethyl Formate and Phosphine to Control Planococcus citri (Hemiptera: Pseudococcidae) on Pineapples.
[So] Source:J Econ Entomol;109(6):2355-2363, 2016 Dec.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Citrus mealybug, Planococcus citri (Risso), is a known quarantine pest that is difficult to control with phosphine (PH ) or low concentrations of ethyl formate (EF), particularly at low temperatures. Methyl bromide (MB) is a fumigant used for quarantine and preshipment (QPS) that can eradicate target pests with short fumigation periods. However, MB, which is an ozone-depleting substance, is scheduled to be phased out in South Korea over the next decade. There is no ideal alternative fumigant to replace MB for QPS of perishable commodities. A laboratory study was conducted to compare the individual effects of EF and PH individually, and the effects of EF mixed with PH as an MB alternative for the control of P. citri adults, nymphs, and eggs. In comparison to treatments with EF and PH individually, EF mixed with PH resulted in high toxicity to all stages of P. citri. The eggs were more tolerant than the nymphs and adults. A mixed treatment of EF and PH achieved complete control of eggs infesting pineapples at concentrations of 25.1/1.0 (EF/PH ) mg/liter at 8 °C for 4 h of exposures. This new combined EF/PH fumigation technology could offer shorter exposure times and less damage to perishable commodities at low temperatures, and could potentially be extended to controlling other quarantine pests as a replacement treatment for fruit and vegetables in which methyl bromide is currently being used.
[Mh] Termos MeSH primário: Ésteres do Ácido Fórmico
Fumigação
Hemípteros
Controle de Insetos
Inseticidas
Fosfinas
[Mh] Termos MeSH secundário: Ananas
Animais
Hemípteros/crescimento & desenvolvimento
Ninfa/crescimento & desenvolvimento
Óvulo/crescimento & desenvolvimento
República da Coreia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Formic Acid Esters); 0 (Insecticides); 0 (Phosphines); 0K3E2L5553 (ethyl formate); FW6947296I (phosphine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


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[PMID]:26952276
[Au] Autor:Trost BM; Saget T; Hung CI
[Ad] Endereço:Department of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
[Ti] Título:Direct Catalytic Asymmetric Mannich Reactions for the Construction of Quaternary Carbon Stereocenters.
[So] Source:J Am Chem Soc;138(11):3659-62, 2016 Mar 23.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Herein, we report a Zn-ProPhenol catalyzed Mannich reaction using α-branched ketones as nucleophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon stereocenters. The reaction can be run on a gram-scale with a low catalyst loading without impacting its efficiency. Moreover, the Mannich adducts can be further elaborated with complete diastereocontrol to access molecules possessing complex stereotriads.
[Mh] Termos MeSH primário: Carbono/química
Iminas/química
Cetonas/química
[Mh] Termos MeSH secundário: Catálise
Ésteres do Ácido Fórmico/química
Bases de Mannich/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Formic Acid Esters); 0 (Imines); 0 (Ketones); 0 (Mannich Bases); 0 (t-butyloxycarbonyl group); 7440-44-0 (Carbon)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160309
[St] Status:MEDLINE
[do] DOI:10.1021/jacs.6b01187


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[PMID]:26860556
[Au] Autor:Zounr RA; Khuhawar MY; Jahangir TM; Alamgir M
[Ad] Endereço:Institute of Advanced Research Studies in Chemical Sciences, University of Sindh.
[Ti] Título:Improved Gas Chromatographic Determination of Guanidino Compounds Using Isovaleroylacetone and Ethyl Chloroformate as Derivatizing Reagents.
[So] Source:Anal Sci;32(2):141-6, 2016.
[Is] ISSN:1348-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:An improved GC method in terms of sensitivity and decrease in the analysis time has been developed for the analysis of eight guanidino compounds: guanidine (G), methylguanidine (MG), creatinine (CTN), guanidinoacetic acid (GAA), guanidinobutyric acid (GBA), guanidinopropionic acid (GPA), argenine (Arg), and guanidinosuccinic acid (GSA), using isovaleroylacetone (IVA) and ethyl chloroformate (ECF) as derivatizing reagents. The separation was obtained from column HP-5 (30 m × 0.32 mm i.d.) with film thickness of 0.25 µm within 11 min. The linear calibrations were obtained with 0.5 to 50 µg/mL with coefficient of determination (R(2)) within 0.9969 - 0.9998. Limits of detections (LODs) were within 5 - 140 ng/mL. The derivatization, separation and determination was repeatable (n = 6) with relative standard deviation (RSD) within 1.2 - 3.1%. The guanidino compounds were determined in deproteinized serum of healthy volunteers and uremic patients within below LOD to 8.8 µg/mL and below LOD to 43.99 µg/mL with RSD within 1.4 - 3.6%. The recovery of guanidino compounds calculated by standard addition from serum was within 96.1 - 98.9%, with RSD 1.4 - 3.6%.
[Mh] Termos MeSH primário: Arginina/análise
Ácido Butírico/análise
Cromatografia Gasosa/métodos
Creatinina/análise
Guanidina/análise
Uremia/sangue
[Mh] Termos MeSH secundário: Acetona/química
Ácidos Bóricos/química
Butiratos/análise
Calibragem
Ésteres do Ácido Fórmico/química
Glicina/análogos & derivados
Glicina/análise
Guanidinas/análise
Voluntários Saudáveis
Seres Humanos
Concentração de Íons de Hidrogênio
Cetonas/química
Limite de Detecção
Metilguanidina/análise
Propionatos/análise
Valores de Referência
Reprodutibilidade dos Testes
Succinatos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Boric Acids); 0 (Butyrates); 0 (Formic Acid Esters); 0 (Guanidines); 0 (Ketones); 0 (Propionates); 0 (Succinates); 09601EZP9R (ethyl chloroformate); 107-92-6 (Butyric Acid); 1364PS73AF (Acetone); 5L0H5Q9VAG (Methylguanidine); 6133-30-8 (guanidinosuccinic acid); 94ZLA3W45F (Arginine); AYI8EX34EU (Creatinine); GO52O1A04E (glycocyamine); JU58VJ6Y3B (Guanidine); R57ZHV85D4 (boric acid); TE7660XO1C (Glycine); UL1984YRKA (guanidinopropionic acid)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160211
[St] Status:MEDLINE
[do] DOI:10.2116/analsci.32.141


  5 / 312 MEDLINE  
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[PMID]:26806113
[Au] Autor:Forbes CR; Pandey AK; Ganguly HK; Yap GP; Zondlo NJ
[Ad] Endereço:Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. zondlo@udel.edu gpyap@udel.edu.
[Ti] Título:4R- and 4S-iodophenyl hydroxyproline, 4R-pentynoyl hydroxyproline, and S-propargyl-4-thiolphenylalanine: conformationally biased and tunable amino acids for bioorthogonal reactions.
[So] Source:Org Biomol Chem;14(7):2327-46, 2016 Feb 21.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bioorthogonal reactions allow the introduction of new functionalities into peptides, proteins, and other biological molecules. The most readily accessible amino acids for bioorthogonal reactions have modest conformational preferences or bases for molecular interactions. Herein we describe the synthesis of 4 novel amino acids containing functional groups for bioorthogonal reactions. (2S,4R)- and (2S,4S)-iodophenyl ethers of hydroxyproline are capable of modification via rapid, specific Suzuki and Sonogashira reactions in water. The synthesis of these amino acids, as Boc-, Fmoc- and free amino acids, was achieved through succinct sequences. These amino acids exhibit well-defined conformational preferences, with the 4S-iodophenyl hydroxyproline crystallographically exhibiting ß-turn (Ï•, ψ∼-80°, 0°) or relatively extended (Ï•, ψ∼-80°, +170°) conformations, while the 4R-diastereomer prefers a more compact conformation (ϕ∼-60°). The aryloxyproline diastereomers present the aryl groups in a highly divergent manner, suggesting their stereospecific use in molecular design, medicinal chemistry, and catalysis. Thus, the 4R- and 4S-iodophenyl hydroxyprolines can be differentially applied in distinct structural contexts. The pentynoate ester of 4R-hydroxyproline introduces an alkyne functional group within an amino acid that prefers compact conformations. The propargyl thioether of 4-thiolphenylalanine was synthesized via copper-mediated cross-coupling reaction of thioacetic acid with protected 4-iodophenylalanine, followed by thiolysis and alkylation. This amino acid combines an alkyne functional group with an aromatic amino acid and the ability to tune aromatic and side chain properties via sulfur oxidation. These amino acids provide novel loci for peptide functionalization, with greater control of conformation possible than with other amino acids containing these functional groups.
[Mh] Termos MeSH primário: Alanina/química
Hidroxiprolina/química
Iodo/química
Peptídeos/síntese química
Fenilacetatos/química
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Ésteres do Ácido Fórmico
Hidroxiprolina/síntese química
Espectroscopia de Ressonância Magnética
Conformação Molecular
Peptídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Formic Acid Esters); 0 (Peptides); 0 (Phenylacetates); 0 (t-butyloxycarbonyl group); 934-87-2 (thiophenyl acetate); 9679TC07X4 (Iodine); OF5P57N2ZX (Alanine); RMB44WO89X (Hydroxyproline)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE
[do] DOI:10.1039/c5ob02473k


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[PMID]:26611919
[Au] Autor:Zwick V; Nurisso A; Simões-Pires C; Bouchet S; Martinet N; Lehotzky A; Ovadi J; Cuendet M; Blanquart C; Bertrand P
[Ad] Endereço:School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland.
[Ti] Título:Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
[So] Source:Bioorg Med Chem Lett;26(1):154-9, 2016 Jan 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Conditions for the metathesis of alkenes in the convergent synthesis of HDAC inhibitors have been improved by continuous catalyst flow injection in the reaction media. Intermediate and target compounds obtained were tested for their ability to induce HDAC inhibition and tubulin acetylation, revealing the key role of the tert-butyloxycarbonyl (BOC) group for more HDAC6 selectivity. Molecular modelling added rationale for this BOC effect.
[Mh] Termos MeSH primário: Alcenos/química
Benzamidas/química
Ésteres do Ácido Fórmico/química
Inibidores de Histona Desacetilases/química
Inibidores de Histona Desacetilases/farmacologia
Histona Desacetilases/metabolismo
Ácidos Hidroxâmicos/química
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Seres Humanos
Modelos Moleculares
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkenes); 0 (Benzamides); 0 (Formic Acid Esters); 0 (Histone Deacetylase Inhibitors); 0 (Hydroxamic Acids); 0 (t-butyloxycarbonyl group); 6X80438640 (benzamide); EC 3.5.1.98 (Histone Deacetylases)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151128
[St] Status:MEDLINE


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[PMID]:26476554
[Au] Autor:Lee BH; Kim HM; Kim BS; Yang JO; Moon YM; Ren Y
[Ti] Título:Evaluation of the Synergistic Effect Between Ethyl Formate and Phospine for Control of Aphis gossypii (Homoptera: Aphididae).
[So] Source:J Econ Entomol;109(1):143-7, 2016 Feb.
[Is] ISSN:0022-0493
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cotton aphid, Aphis gossypii Glover, is known as a quarantine pest that is hard to control with short periods of fumigation with phosphine (PH(3)) or low concentrations of ethyl formate. Moreover, low-temperature fumigation with ethyl formate can lead to phototoxic damage of some perishable commodities. Therefore, a laboratory study was conducted to evaluate the synergistic effect of mixing ethyl formate and PH(3) for the treatment of adults and nymphs of A. gossypii. Combined toxicity was observed and compared with a single dose of eitherrethyl formate or PH(3). When insects were exposed to 0.5 g/m(3) of PH(3) combined with different levels of ethyl formate from 1.6 to 16.3 g/m(3) at 5 and 20C for 2 h, L(Ct)(50) and L(Ct)(99) values were greatly reduced in comparison with a single dose of either ethyl formate or PH(3). The synergistic ratio (SR) is described as L(Ct) of ethyl formate alone/L(Ct) of ethyl formate + PH(3). The SR values of L(Ct)(50) and L(Ct)(99) for adult A. gossypii at 5C were 4.55 and 2.33, respectively. However, at 20C the SR levels of L(Ct)(50) and L(Ct)(99) were 2.22 and 1.45, respectively, but still showed significant synergism (significant difference, P<0.5). This new technology could meet quarantine and preshipment requirements for shorter exposure times and less damage of perishable commodities, and could also be extended for controlling other quarantine pests and thereby be a useful alternative to methyl bromide for fruit and vegetable applications.
[Mh] Termos MeSH primário: Afídeos
Ésteres do Ácido Fórmico
Fumigação
Controle de Insetos
Inseticidas
Fosfinas
[Mh] Termos MeSH secundário: Animais
Afídeos/crescimento & desenvolvimento
Relação Dose-Resposta a Droga
Sinergismo Farmacológico
Ninfa/crescimento & desenvolvimento
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Formic Acid Esters); 0 (Insecticides); 0 (Phosphines); 0K3E2L5553 (ethyl formate); FW6947296I (phosphine)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151019
[St] Status:MEDLINE


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[PMID]:24593666
[Au] Autor:Osathananda R; Wiwatwarrapan C
[Ad] Endereço:Faculty of Dentistry, Department of Prosthodontics, Chulalongkorn University, Bangkok, Thailand.
[Ti] Título:Surface treatment with methyl formate-methyl acetate increased the shear bond strength between reline resins and denture base resin.
[So] Source:Gerodontology;33(2):147-54, 2016 Jun.
[Is] ISSN:1741-2358
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chemical surface treatment increases the shear bond strength (SBS) between hard reline resins (HRRs) and denture base resin. OBJECTIVE: To evaluate the effect of methyl formate-methyl acetate (MF-MA), when used as a surface treatment agent, on the SBS between denture base resin and different HRRs. MATERIALS AND METHODS: One hundred and twenty specimens of heat-polymerised acrylic resin denture base (Meliodent(®) ) were divided into 12 groups. These groups comprised denture base relined with three self-polymerised HRRs [Unifast trad(®) (UT), Tokuyama(®) RebaseII Fast (TR), Ufi gel hard(®) (UG)], and treated with their respective Bonding Agent (BA) or by MF:MA solutions at ratios of 35:65, 25:75, and 15:85 for 15 s. The SBS was measured using a Universal Testing Machine. The data were analysed using two-way anova and post hoc Tukey's analysis at p < 0.05. RESULTS: The highest SBS was in the UT treated with MF:MA at a ratio of 25:75 group, followed by UT treated with MF:MA at ratios of 15:85, 35:65, UT treated with BA, and all UG treated with MF:MA groups. The SBS of the UT treated with MF:MA at a ratio of 25:75 group was significantly higher than those of the groups treated with BA. The SBS of the UG treated with MF:MA groups was significantly higher than control. The TR groups treated with BA or MF:MA groups showed no significant difference in SBS. CONCLUSION: Surface treatment with MF-MA significantly enhanced the SBS of denture base resin and UT and UG compared to that of the groups treated with BA.
[Mh] Termos MeSH primário: Acetatos
Resinas Acrílicas
Colagem Dentária/métodos
Bases de Dentadura
Ésteres do Ácido Fórmico
[Mh] Termos MeSH secundário: Reembasamento de Dentadura/métodos
Seres Humanos
Teste de Materiais
Resistência ao Cisalhamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Acrylic Resins); 0 (Formic Acid Esters); 1MPH591FTG (methyl formate); W684QT396F (methyl acetate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:140306
[St] Status:MEDLINE
[do] DOI:10.1111/ger.12120


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[PMID]:26575732
[Au] Autor:Ahmad M; Helms V; Lengauer T; Kalinina OV
[Ad] Endereço:Department for Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics , Campus E1 4, 66123 Saarbrücken, Germany.
[Ti] Título:How Molecular Conformational Changes Affect Changes in Free Energy.
[So] Source:J Chem Theory Comput;11(7):2945-57, 2015 Jul 14.
[Is] ISSN:1549-9626
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A simple quantitative relationship between the molecular conformational changes and the corresponding changes in the free energy is presented. The change in free energy is the sum of that part of the enthalpic change that is due to the externally applied work (perturbation) and of that part of the entropic change, termed dissipative entropy, that is related to the conformational changes. The dissipative entropy is equivalent to the relative entropy, a concept from information theory, between the distributions of the conformations in the initial and the final states. The remaining change in entropy (nondissipative) cancels exactly with the remaining enthalpic change. The calculation of the dissipative entropy is demonstrated to pose the main difficulty in free energy computation. The straightforward decomposition of the dissipative entropy into contributions from different parts of the system promises to improve the understanding of the role of conformational changes in biochemical reactions.
[Mh] Termos MeSH primário: Ésteres do Ácido Fórmico/química
Guaiacol/química
Termodinâmica
[Mh] Termos MeSH secundário: Conformação Molecular
Simulação de Dinâmica Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Formic Acid Esters); 1MPH591FTG (methyl formate); 6JKA7MAH9C (Guaiacol)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151120
[Lr] Data última revisão:
151120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jctc.5b00235


  10 / 312 MEDLINE  
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[PMID]:26470389
[Au] Autor:Kim HK; Lee SW; Kim JI; Yang JO; Koo HN; Kim GH
[Ad] Endereço:Department of Plant Medicine, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea. khkim@chungbuk.ac.kr.
[Ti] Título:Synergistic Effects of Oxygen on Phosphine and Ethyl Formate for the Control of Phthorimaea operculella (Lepidoptera: Gelechiidae).
[So] Source:J Econ Entomol;108(6):2572-80, 2015 Dec.
[Is] ISSN:0022-0493
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phosphine (PH3) and ethyl formate (EF) are two potentially powerful postharvest fumigant insecticides. We investigated the effectiveness of both PH3 and EF as fumigants at all developmental stages of the potato tuber moth Phthorimaea operculella Zeller, and we also studied the synergistic effects of these fumigants under controlled atmospheres of 50 and 80% oxygen (O2). The larval stage of P. operculella was the most susceptible to fumigation with PH3 at both 5°C and 20°C. All of the developmental stages showed greater susceptibility to PH3 at 20°C than at 5°C, whereas the susceptibility of adult P. operculella to this fumigant was not affected by temperature. The toxicity of EF did not differ with temperature for any of the P. operculella developmental stages. The atmospheric oxidation of PH3 increased the toxicity of this fumigant toward all developmental stages at both temperatures. In contrast, no differences in toxicity were observed for oxidized EF compared with EF alone at any developmental stage. In conclusion, using fumigation tests, we showed that atmospherically oxidized PH3 was much more effective against P. operculella than PH3 alone, demonstrating a synergistic effect for this fumigant and O2. Therefore, treatment with PH3 and high concentrations of O2, as described in this study, could be useful for managing the postharvest pest P. operculella.
[Mh] Termos MeSH primário: Ésteres do Ácido Fórmico
Fumigação
Mariposas
Oxigênio
Fosfinas
[Mh] Termos MeSH secundário: Animais
Sinergismo Farmacológico
Larva
Óvulo
Pupa
Testes de Toxicidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Formic Acid Esters); 0 (Phosphines); 0K3E2L5553 (ethyl formate); FW6947296I (phosphine); S88TT14065 (Oxygen)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151016
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tov244



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