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[PMID]: 27881023 [Au] Autor: Tyrväinen T; Nordback I; Toikka J; Piiroinen A; Herzig KH; Mäkelä K; Sand J [Ad] Endereço: a Department of Gastroenterology and Alimentary Tract Surgery , Tampere University Hospital , Tampere , Finland. [Ti] Título: Impaired gallbladder function in patients after total gastrectomy. [So] Source: Scand J Gastroenterol;52(3):334-337, 2017 Mar. [Is] ISSN: 1502-7708 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND AND AIMS: The incidence of gallstones and gallbladder sludge is higher in patients after total gastrectomy than in general population. Formation of gallstones after gastrectomy is multifactorial. Here, we investigate the changes in gallbladder and biliary tract functions by cholescintygraphy and monitored changes in cholecystokinin (CCK) release in long-term survivors after total gastrectomy for gastric carcinoma. MATERIAL AND METHODS: Patients had undergone total gastrectomy for gastric carcinoma at least five years ago. The final study population consisted of 25 patients. RESULTS: Eight patients had undergone cholecystectomy before or at the time of gastrectomy. Gallstone formation was observed in seven of the remaining 17 patients during follow-up (41%). Maximum uptake of radioactivity and gallbladder maximum uptake was significantly delayed in the gastrectomy group than in the control group. There was no significant difference in CCK levels after the overnight fasting and at 60 minutes after stimulation among patients with or without stones in situ compared with healthy volunteers, but 30 minutes after the energy-rich drink patients had higher CCK levels than the control group. CONCLUSIONS: In gastrectomy patients, technetium isotope visualisation of the gallbladder and time for maximum activity was significantly delayed. This may indicate impaired gallbladder function. On the contrary, CCK release was not impaired. [Mh] Termos MeSH primário: Sistema Biliar/diagnóstico por imagem Colecistectomia/efeitos adversos Colecistocinina/sangue Vesícula Biliar/fisiopatologia Cálculos Biliares/diagnóstico por imagem Gastrectomia/efeitos adversos [Mh] Termos MeSH secundário: Idoso Carcinoma/cirurgia Estudos de Casos e Controles Feminino Seguimentos Seres Humanos Masculino Meia-Idade Análise Multivariada Cintilografia Neoplasias Gástricas/cirurgia Disofenina Tecnécio Tc 99m [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 9011-97-6 (Cholecystokinin); QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170911 [Lr] Data última revisão: 170911 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161125 [St] Status: MEDLINE [do] DOI: 10.1080/00365521.2016.1256422

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[PMID]: 27834726 [Au] Autor: Fakhri AA; Hussain A; Taiyebi A; Fakhri AF [Ad] Endereço: Department of Nuclear Medicine and Molecular Imaging, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York; and asiffakh@buffalo.edu. [Ti] Título: Duodenal Obstruction on 99mTc-DISIDA Cholescintigraphy: A Noninvasive Approach to Bowel Obstruction Diagnosis. [So] Source: J Nucl Med Technol;44(4):265-266, 2016 Dec. [Is] ISSN: 1535-5675 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We present a case study of a 56-y-old man who was admitted with acute abdominal pain and was found to have retroperitoneal hematoma from a ruptured duodenal aneurysm. Tc-diisopropyliminodiacetic acid cholescintigraphy showed incidental absent transit of radiotracer into the distal duodenum and severe enterogastric reflux, thought to be secondary to duodenal obstruction from the hematoma. Findings were confirmed on esophagogastroduodenoscopy, and the patient improved after subsequent gastrojejunostomy. [Mh] Termos MeSH primário: Obstrução Duodenal/diagnóstico por imagem Cintilografia Disofenina Tecnécio Tc 99m [Mh] Termos MeSH secundário: Obstrução Duodenal/cirurgia Derivação Gástrica Seres Humanos Masculino Meia-Idade [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170228 [Lr] Data última revisão: 170228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161112 [St] Status: MEDLINE

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[PMID]: 26140885 [Au] Autor: Eckenrode AH; Ewing JA; Kotrady J; Hale AL; Smith DE [Ad] Endereço: Greenville Health System, Greenville, South Carolina, USA. [Ti] Título: HIDA Scan with Ejection Fraction Is over Utilized in the Management of Biliary Dyskinesia. [So] Source: Am Surg;81(7):669-73, 2015 Jul. [Is] ISSN: 1555-9823 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Patients with upper abdominal pain, nausea, and vomiting are often evaluated with ultrasound to diagnose symptomatic cholelithiasis or cholecystitis. With a normal ultrasound, a hepatobiliary iminodiacetic acid (HIDA) scan with ejection fraction (EF) is recommended to evaluate gallbladder function. The purpose of this study was to evaluate whether the HIDA scan with EF was appropriately utilized in considering cholecystectomy. Over 18 months, we performed 1533 HIDA scans with EF. After exclusion, 1501 were analyzable, 438 of whom underwent laparoscopic cholecystectomy. Patients were divided into two groups: those with typical and atypical symptoms of biliary colic. Our primary endpoint was symptom resolution of those who underwent laparoscopic cholecystectomy. Symptom resolution was assessed by chart review of postop visits or readmissions. In patients with typical symptoms, resolution occurred in 66 per cent of patients with positive HIDA and 77 per cent with negative HIDA (P = 0.292). In patients with atypical symptoms, resolution occurred in 64 per cent of patients with positive HIDA and 43 per cent with negative HIDA (P = 0.013). A HIDA scan with EF was not useful in patients with typical symptoms of biliary colic and negative ultrasounds, and should not be used to make a decision for cholecystectomy. However, this test can be helpful in patients with atypical symptoms, as it does predict symptom improvement in this group. [Mh] Termos MeSH primário: Discinesia Biliar/diagnóstico por imagem Técnicas de Diagnóstico do Sistema Digestório/utilização Iminoácidos Compostos Radiofarmacêuticos Disofenina Tecnécio Tc 99m [Mh] Termos MeSH secundário: Adulto Colecistectomia Laparoscópica Feminino Seres Humanos Masculino Meia-Idade Valor Preditivo dos Testes Cintilografia Estudos Retrospectivos Ultrassonografia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Imino Acids); 0 (Radiopharmaceuticals); EK22QV7701 (lidofenin); QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1509 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150705 [St] Status: MEDLINE

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[PMID]: 25754361 [Au] Autor: Lo RC; Huang WL; Fan YM [Ad] Endereço: National Taipei University of Technology, Dept. of Electronic Engineering & Graduate Institute of Computer and Communication Engineering, Taipei, Taiwan. Electronic address: rclo@ntut.edu.tw. [Ti] Título: Evaluation of bile reflux in HIDA images based on fluid mechanics. [So] Source: Comput Biol Med;60:51-65, 2015 May. [Is] ISSN: 1879-0534 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We propose a new method to help physicians assess, using a hepatobiliary iminodiacetic acid scan image, whether or not there is bile reflux into the stomach. The degree of bile reflux is an important index for clinical diagnosis of stomach diseases. The proposed method applies image-processing technology combined with a hydrodynamic model to determine the extent of bile reflux or whether the duodenum is also folded above the stomach. This condition in 2D dynamic images suggests that bile refluxes into the stomach, when endoscopy shows no bile reflux. In this study, we used optical flow to analyze images from Tc99m-diisopropyl iminodiacetic acid cholescintigraphy (Tc99m-DISIDA) to ascertain the direction and velocity of bile passing through the pylorus. In clinical diagnoses, single photon emission computed tomography (SPECT) is the main clinical tool for evaluating functional images of hepatobiliary metabolism. Computed tomography (CT) shows anatomical images of the external contours of the stomach, liver, and biliary extent. By exploiting the functional fusion of the two kinds of medical image, physicians can obtain a more accurate diagnosis. We accordingly reconstructed 3D images from SPECT and CT to help physicians choose which cross sections to fuse with software and to help them more accurately diagnose the extent and quantity of bile reflux. [Mh] Termos MeSH primário: Refluxo Biliar/diagnóstico por imagem Bile/química Processamento de Imagem Assistida por Computador Microfluídica Interpretação de Imagem Radiográfica Assistida por Computador [Mh] Termos MeSH secundário: Idoso Algoritmos Diagnóstico por Computador Duodeno/diagnóstico por imagem Endoscopia Feminino Seres Humanos Imagem Tridimensional Masculino Meia-Idade Software Estômago/diagnóstico por imagem Disofenina Tecnécio Tc 99m/química Tomografia Computadorizada de Emissão de Fóton Único Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1601 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150311 [St] Status: MEDLINE

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[PMID]: 25146931 [Au] Autor: LeBedis CA; Anderson SW; Mercier G; Kussman S; Coleman SL; Golden L; Penn DR; Uyeda JW; Soto JA [Ad] Endereço: Department of Radiology, Boston Medical Center, Boston University School of Medicine, FGH Building, 820 Harrison Ave, Boston, MA, 02118, USA, christina.lebedis@bmc.org. [Ti] Título: The utility of CT for predicting bile leaks in hepatic trauma. [So] Source: Emerg Radiol;22(2):101-7, 2015 Apr. [Is] ISSN: 1438-1435 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The purpose of this study was to determine the efficacy of CT to predict the development of bile leaks in hepatic trauma. This HIPAA-compliant retrospective study was IRB approved and consent was waived. All patients who sustained hepatic trauma between January 1, 2006, and January 31, 2012, and who underwent CT and hepatobiliary scans during the same hospital admission were included. One hundred and thirty-two patients met the inclusion criteria. Comparison between the presence of biliary injury relative to American Association for the Surgery of Trauma (AAST) hepatic injury grade and mean distance of the hepatic laceration to the inferior vena cava (IVC) was made. The ability of free fluid to predict bile injury was analyzed. Forty-one (31 %) of the 132 patients had positive hepatobiliary scans. Of these 41 patients, seven (17 %) sustained low-grade and 34 (83 %) sustained high-grade hepatic injury compared with the 37 (41 %) low-grade and 54 (59 %) high-grade hepatic injuries in the negative hepatobiliary scan group. The mean distance to the IVC was 2.4 cm (SD 2.9 cm) and 3.6 cm (SD 3.3 cm) in patients with and without bile leaks, respectively. A statistically significant difference in the proportion of high-grade injuries and the mean distance from the IVC between the two groups was identified. The presence of free fluid on CT is sensitive, but not specific, for detecting a bile leak. CT findings, including AAST liver injury grade and location of the liver laceration, are able to predict which patients are at risk for developing bile leaks as seen on hepatobiliary scintigraphy, whereas the presence of free fluid is not. [Mh] Termos MeSH primário: Bile Fígado/lesões Tomografia Computadorizada por Raios X Ferimentos não Penetrantes/diagnóstico por imagem [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Meios de Contraste Feminino Seres Humanos Iminoácidos Escala de Gravidade do Ferimento Lacerações/diagnóstico por imagem Masculino Meia-Idade Compostos de Organotecnécio Valor Preditivo dos Testes Cintilografia Compostos Radiofarmacêuticos Estudos Retrospectivos Disofenina Tecnécio Tc 99m Ácidos Tri-Iodobenzoicos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); 0 (Imino Acids); 0 (Organotechnetium Compounds); 0 (Radiopharmaceuticals); 0 (Triiodobenzoic Acids); F2NQ468L52 (technetium Tc 99m mebrofenin); N3RIB7X24K (ioversol); QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1512 [Cu] Atualização por classe: 171013 [Lr] Data última revisão: 171013 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140823 [St] Status: MEDLINE [do] DOI: 10.1007/s10140-014-1262-9

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[PMID]: 25097073 [Au] Autor: Fahey F; Zukotynski K; Zurakowski D; Markelewicz R; Falone A; Vitello M; Cao X; Grant F; Drubach L; Vija AH; Bhattacharya M; Ding X; Bar-Sever Z; Gelfand M; Treves ST [Ad] Endereço: Division of Nuclear Medicine and Molecular Imaging, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA, frederic.fahey@childrens.harvard.edu. [Ti] Título: Beyond current guidelines: reduction in minimum administered radiopharmaceutical activity with preserved diagnostic image quality in pediatric hepatobiliary scintigraphy. [So] Source: Eur J Nucl Med Mol Imaging;41(12):2346-53, 2014 Dec. [Is] ISSN: 1619-7089 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: PURPOSE: To determine if the minimum administered radiopharmaceutical activity for hepatobiliary scintigraphy can be reduced while preserving diagnostic image quality using enhanced planar processing (EPP). METHODS: A total of 40 infants between 10 and 270 days old (body mass 2.2 - 6.5 kg) had hepatobiliary scintigraphy during the period 2004 - 2010 following the intravenous administration of either (99m)Tc-mebrofenin (18 patients) or (99m)Tc-disofenin (22 patients). Due to the small size of these patients, they all received the minimum administered activity of 18.5 MBq consistent with the North American Consensus Guidelines. Six nuclear medicine physicians subjectively graded the acceptability of the image quality for clinical interpretation using a four-point scale (not acceptable, fair, good, excellent). Each physician independently graded seven image sets including the original study (full activity) and simulated reduced activity studies using binomial subsampling (50% of full activity, 25% of full activity and activity reduced by weight), with and without EPP. RESULTS: For full-activity studies, 98% were deemed acceptable by the six physicians for clinical interpretation. The percentages of acceptable 50% reduced activity studies with and without EPP were not significantly different from the percentage of acceptable full-activity studies (P = 0.193 and P = 0.998, respectively). The percentage of acceptable 25% reduced activity studies without EPP was significantly different from the percentage of acceptable full-activity studies (P < 0.001); however, this difference vanished when EPP was applied (P = 0.482). The activity reduced by weight ranged from 1.85 to 4.81 MBq (10% to 26% of full dose) and the percentages of acceptable studies with and without EPP were significantly different from the percentage of acceptable full-activity studies (P < 0.001 and P = 0.02, respectively). CONCLUSION: Clinically interpretable hepatobiliary scintigraphy images can be obtained in infants when the minimum administered activity is substantially reduced. Without EPP, clinically acceptable images may be produced with a reduction of 50%, and with EPP, a reduction of 75% or more may be possible. [Mh] Termos MeSH primário: Sistema Biliar/diagnóstico por imagem Iminoácidos/administração & dosagem Fígado/diagnóstico por imagem Compostos de Organotecnécio/administração & dosagem Guias de Prática Clínica como Assunto Compostos Radiofarmacêuticos/administração & dosagem Disofenina Tecnécio Tc 99m/administração & dosagem Tomografia Computadorizada de Emissão de Fóton Único/métodos [Mh] Termos MeSH secundário: Feminino Seres Humanos Processamento de Imagem Assistida por Computador/métodos Lactente Recém-Nascido Masculino Dose de Radiação Tomografia Computadorizada de Emissão de Fóton Único/normas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Imino Acids); 0 (Organotechnetium Compounds); 0 (Radiopharmaceuticals); F2NQ468L52 (technetium Tc 99m mebrofenin); QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1508 [Cu] Atualização por classe: 170924 [Lr] Data última revisão: 170924 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140807 [St] Status: MEDLINE [do] DOI: 10.1007/s00259-014-2860-1

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[PMID]: 23917780 [Au] Autor: Ueda CE; Ichiki WA; Ruiz MF; Santos AO; Etchebehere EC [Ad] Endereço: From the Division of Nuclear Medicine and PET/CT, Sirio-Libanes Hospital, São Paulo, Brazil. [Ti] Título: 99mTc-DISIDA uptake in liver lesion and pulmonary metastases shown on SPECT/CT in a patient with hepatocellular carcinoma. [So] Source: Clin Nucl Med;39(1):74-6, 2014 Jan. [Is] ISSN: 1536-0229 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A 43-year-old man, previously submitted to right hepatectomy, right hepatic artery chemoembolization, and surgical resection of liver lesions, with well-differentiated and moderately differentiated hepatocellular carcinoma (HCC) confirmed by histopathology, underwent cholescintigraphy with Tc diisopropyliminodiacetic acid (Tc-DISIDA) due to recurrent cholangitis. The scintigraphic images and the coregistered CT images showed radiotracer uptake in an area of biliary ectasia near the hepatic surface (which may be associated with recurrent cholangitis), in a hepatic nodule, and in multiple pulmonary metastases. [Mh] Termos MeSH primário: Carcinoma Hepatocelular/patologia Neoplasias Hepáticas/patologia Neoplasias Pulmonares/diagnóstico Neoplasias Pulmonares/secundário Imagem Multimodal Disofenina Tecnécio Tc 99m/metabolismo Tomografia Computadorizada de Emissão de Fóton Único [Mh] Termos MeSH secundário: Adulto Idoso Seres Humanos Neoplasias Pulmonares/metabolismo Masculino Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1408 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130807 [St] Status: MEDLINE [do] DOI: 10.1097/RLU.0b013e3182815d28

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[PMID]: 23353095 [Au] Autor: Brboric J; Jovanovic MS; Vranjes-Duric S; Cudina O; Markovic B; Vladimirov S [Ad] Endereço: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia. [Ti] Título: The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia. [So] Source: Appl Radiat Isot;74:31-5, 2013 Apr. [Is] ISSN: 1872-9800 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial (99m)Tc-BROMIDA. Log P of (99m)Tc-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to (99m)Tc-BROMIDA, (99m)Tc-DIETHYLIODIDA has: (a) better biliary excretion (2.76±0.15%ID/g versus 1.83±0.10%ID/g); (b) faster hepatic clearance (2.90±0.21%ID/g versus 7.47±0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15min. It is proved that (99m)Tc-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion. [Mh] Termos MeSH primário: Hiperbilirrubinemia/diagnóstico por imagem Iminoácidos Compostos de Organotecnécio [Mh] Termos MeSH secundário: Animais Sistema Biliar/diagnóstico por imagem Iminoácidos/química Fígado/diagnóstico por imagem Estrutura Molecular Compostos de Organotecnécio/química Cintilografia Compostos Radiofarmacêuticos/química Ratos Ratos Wistar Software Ácido Dietil-Iminodiacético Tecnécio Tc 99m/química Disofenina Tecnécio Tc 99m/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Imino Acids); 0 (Organotechnetium Compounds); 0 (Radiopharmaceuticals); 0 (Technetium Tc 99m Diethyl-iminodiacetic Acid); F2NQ468L52 (technetium Tc 99m mebrofenin); QTJ2VIW97T (Technetium Tc 99m Disofenin); XQM2L81M8Z (iminodiacetic acid) [Em] Mês de entrada: 1309 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130129 [St] Status: MEDLINE

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[PMID]: 21998045 [Au] Autor: Lee SY; Kim GC; Choe BH; Ryeom HK; Jang YJ; Kim HJ; Park JY; Cho SM [Ad] Endereço: Department of Radiology, Kyungpook National University School of Medicine, 101 Dongin dong 2 Ga, Jung gu, Daegu 700-422, Republic of Korea. [Ti] Título: Efficacy of US-guided percutaneous cholecystocholangiography for the early exclusion and type determination of biliary atresia. [So] Source: Radiology;261(3):916-22, 2011 Dec. [Is] ISSN: 1527-1315 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To evaluate the efficacy of ultrasonographically (US)-guided percutaneous cholecystocholangiography (PCC) for early diagnosis and characterization of biliary atresia in infants with cholestatic liver disease. MATERIALS AND METHODS: Institutional review board approval was obtained for this study. Parental informed written consent was obtained. From October 2003 to August 2010, 22 infants (12 male, 10 female; age range, 1-138 days) were referred to the radiology department for PCC. Indications for PCC were suspected biliary atresia at 24-hour delayed technetium 99m-diisopropyl-phenylcarbamoylmethyl-iminodiacetic acid (DISIDA) scintigraphy because no excretion was observed in the small bowel (n = 17) or when the results of the scan or liver biopsy could not be obtained within 3 days because of a delay in schedule (n = 5). A diagnosis of biliary atresia was excluded when there was contrast material visualized in the gallbladder, biliary system, and passage to the duodenum. Patients with biliary atresia underwent surgery as the reference standard. RESULTS: Among the 18 patients who underwent successful PCC, biliary atresia was excluded in 13, with diagnoses as follows: total parenteral nutrition-associated cholestasis (TPNAC) (n = 6), neonatal hepatitis (n = 4), congenital syphilis (n = 1), neonatal lupus (n = 1), and congenital cytomegalovirus hepatitis (n = 1). Biliary atresia was diagnosed in five patients (four with type IIIb and one with type IIIa) and was confirmed at surgery. In four infants in whom US-guided gallbladder puncture had failed, biliary atresia (n = 2) and TPNAC (n = 2) were diagnosed. CONCLUSION: PCC is a safe and useful technique for early exclusion when biliary atresia cannot be ruled out after traditional screening tests; in addition, it may be useful for preoperative type determination of biliary atresia. © RSNA, 2011. [Mh] Termos MeSH primário: Atresia Biliar/diagnóstico por imagem Colangiografia/métodos Colecistografia/métodos Colestase/diagnóstico por imagem Ultrassonografia de Intervenção [Mh] Termos MeSH secundário: Atresia Biliar/cirurgia Colestase/cirurgia Meios de Contraste Diagnóstico Precoce Feminino Seres Humanos Lactente Recém-Nascido Masculino Cintilografia Compostos Radiofarmacêuticos Disofenina Tecnécio Tc 99m Resultado do Tratamento Ácidos Tri-Iodobenzoicos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Contrast Media); 0 (Radiopharmaceuticals); 0 (Triiodobenzoic Acids); N3RIB7X24K (ioversol); QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1201 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 111015 [St] Status: MEDLINE [do] DOI: 10.1148/radiol.11110665

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[PMID]: 20461772 [Au] Autor: Kim JW; Yoon H; Kong SH; Kim JS; Paeng JC; Lee HJ; Lee KU; Yang HK [Ad] Endereço: Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea. [Ti] Título: Analysis of esophageal reflux after proximal gastrectomy measured by wireless ambulatory 24-hr esophageal pH monitoring and TC-99m diisopropyliminodiacetic acid (DISIDA) scan. [So] Source: J Surg Oncol;101(7):626-33, 2010 Jun 01. [Is] ISSN: 1096-9098 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND AND OBJECTIVES: Reflux is one of the most common sequela after proximal gastrectomy (PG). The aim of this study was to find a predicting factor related to the character of esophageal reflux after PG. METHODS: Wireless ambulatory 24-hr pH monitoring (for acid reflux, AR) and diisopropyliminodiacetic acid hepatobiliary scan (for bile reflux, BR) were performed on 24 patients who had reflux symptoms after PG with esophagogastrostomy from July 2008 to March 2009. Endoscopic examination was done and the length of remnant stomach (LoRS) was measure by postoperative UGI series. RESULTS: Eleven patients (45.8%) had only BR, 7 (29.2%) had AR only, Two patients (8.3%) had both acid and BR, and 3 (12.5%) had neither. The LoRS along greater curvature was significantly shorter in patients with only BR (16.11 +/- 2.87 cm) than in patients with only AR (23.69 +/- 6.15 cm, P = 0.003). Severity of symptoms or esophagitis was not significantly correlated with the content of acid or BR. CONCLUSION: Reflux symptom after PG is caused by either bile or acid rather than both. Character of reflux was related to the LoRS. [Mh] Termos MeSH primário: Refluxo Biliar/diagnóstico por imagem Monitoramento do pH Esofágico Ácido Gástrico/secreção Refluxo Gastroesofágico/diagnóstico Síndromes Pós-Gastrectomia/diagnóstico [Mh] Termos MeSH secundário: Monitoramento do pH Esofágico/efeitos adversos Monitoramento do pH Esofágico/instrumentação Esofagoscopia Feminino Seres Humanos Masculino Meia-Idade Síndromes Pós-Gastrectomia/diagnóstico por imagem Cintilografia Compostos Radiofarmacêuticos Índice de Gravidade de Doença Disofenina Tecnécio Tc 99m [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Radiopharmaceuticals); QTJ2VIW97T (Technetium Tc 99m Disofenin) [Em] Mês de entrada: 1006 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 100513 [St] Status: MEDLINE [do] DOI: 10.1002/jso.21560

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