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  1 / 8627 MEDLINE  
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[PMID]:29031613
[Au] Autor:Majd H; King MS; Smith AC; Kunji ERS
[Ad] Endereço:Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
[Ti] Título:Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis.
[So] Source:Biochim Biophys Acta;1859(1):1-7, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Missense mutations of the human mitochondrial citrate carrier, encoded by the SLC25A1 gene, lead to an autosomal recessive neurometabolic disorder characterised by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor development, often resulting in early death. Here, we have measured the effect of all twelve known pathogenic mutations on the transport activity. The results show that nine mutations abolish transport of citrate completely, whereas the other three reduce the transport rate by >70%, indicating that impaired citrate transport is the most likely primary cause of the disease. Some mutations may be detrimental to the structure of the carrier, whereas others may impair key functional elements, such as the substrate binding site and the salt bridge network on the matrix side of the carrier. To understand the consequences of impaired citrate transport on metabolism, the substrate specificity was also determined, showing that the human citrate carrier predominantly transports citrate, isocitrate, cis-aconitate, phosphoenolpyruvate and malate. Although D-2- and L-2 hydroxyglutaric aciduria is a metabolic hallmark of the disease, it is unlikely that the citrate carrier plays a significant role in the removal of hydroxyglutarate from the cytosol for oxidation to oxoglutarate in the mitochondrial matrix. In contrast, computer simulations of central metabolism predict that the export of citrate from the mitochondrion cannot be fully compensated by other pathways, restricting the cytosolic production of acetyl-CoA that is required for the synthesis of lipids, sterols, dolichols and ubiquinone, which in turn explains the severe disease phenotypes.
[Mh] Termos MeSH primário: Proteínas de Transporte de Ânions
Ácido Cítrico/metabolismo
Simulação por Computador
Dolicol
Proteínas Mitocondriais
Modelos Biológicos
Mutação de Sentido Incorreto
Esteróis
Ubiquinona
[Mh] Termos MeSH secundário: Proteínas de Transporte de Ânions/química
Proteínas de Transporte de Ânions/genética
Proteínas de Transporte de Ânions/metabolismo
Transporte Biológico Ativo/genética
Encefalopatias Metabólicas Congênitas/enzimologia
Encefalopatias Metabólicas Congênitas/genética
Domínio Catalítico
Dolicol/biossíntese
Dolicol/química
Dolicol/genética
Seres Humanos
Proteínas Mitocondriais/química
Proteínas Mitocondriais/genética
Proteínas Mitocondriais/metabolismo
Esteróis/biossíntese
Esteróis/química
Esteróis/metabolismo
Ubiquinona/biossíntese
Ubiquinona/química
Ubiquinona/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anion Transport Proteins); 0 (Mitochondrial Proteins); 0 (Slc25a1 protein, human); 0 (Sterols); 1339-63-5 (Ubiquinone); 2067-66-5 (Dolichol); 2968PHW8QP (Citric Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE


  2 / 8627 MEDLINE  
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[PMID]:29413574
[Au] Autor:Gao H; Yu X; Sun R; Yang N; He J; Tao M; Gu H; Yan C; Aa J; Wang G
[Ad] Endereço:Laboratory of Metabolomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Quantitative GC-MS assay of citric acid from humans and db/db mice blood serum to assist the diagnosis of diabetic nephropathy.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:28-34, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The early diagnosis of diabetic nephropathy (DN) is rather challenging. Our previous study suggested that citric acid is a potential marker for the early diagnosis of diabetic nephropathy in db/db mice. For the first time, in this study, a surrogate analyte of C -citric acid was employed to generate calibration curves for the quantitative measurement of the endogenous citric acid in the sera of db/db mice and diabetic nephropathy patients by GC/MS after the analytes were extracted, methoximated and trimethylsilylated. The constant response factor of C -citric acid versus citric acid over the linear range indicated the identical ionization efficiency of these two compounds. The full validation assessments suggested that the method is sensitive, specific, reliable, reproducible and has acceptable parameters. Statistical analysis revealed cut-off citric acid concentrations of 29.24 µg/mL with a 95% confidence interval between 32.75 and 39.16 µg/mL in the diabetic nephropathy patients and 16.74 and 22.57 µg/mL in the normal controls. The areas under the receiver operating characteristic curves indicated accuracies of over 90% for the diagnoses of early diabetic nephropathy in both humans and db/db mice, which suggests that the serum citric acid level is potentially a biomarker that could assist in the diagnosis of diabetic nephropathy.
[Mh] Termos MeSH primário: Ácido Cítrico/sangue
Nefropatias Diabéticas/metabolismo
Cromatografia Gasosa-Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Animais
Nefropatias Diabéticas/diagnóstico
Estabilidade de Medicamentos
Seres Humanos
Modelos Lineares
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
2968PHW8QP (Citric Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  3 / 8627 MEDLINE  
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[PMID]:29239435
[Au] Autor:Li Y; Tang A; Liu Z; Peng L; Yuan Y; Shi X; Yang C; Teng F
[Ad] Endereço:Department of Chemistry, School of Science, Beijing JiaoTong University, Beijing 100044, P. R. China. awtang@bjtu.edu.cn chy@bjtu.edu.cn.
[Ti] Título:Formation of uniform carrot-like Cu S -CuInS heteronanostructures assisted by citric acid at the oil/aqueous interface.
[So] Source:Dalton Trans;47(1):67-73, 2018 Jan 07.
[Is] ISSN:1477-9234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple two-phase strategy was developed to prepare Cu S -CuInS heterostructures (HNS) at the oil/aqueous interface, in which the In(OH) phase was often obtained in the products due to the reaction between indium ions and hydroxyl ions in the aqueous phase. To prevent the formation of the In(OH) phase, citric acid was incorporated into the aqueous phase to assist in the synthesis of uniform carrot-like Cu S -CuInS semiconductor HNS at the oil/aqueous interface for the first time. By manipulating the dosage of citric acid and Cu/In precursor ratios, the morphology of the Cu S -CuInS HNS could be tailored from mushroom to carrot-like, and the presence of citric acid played a critical role in the synthesis of high-quality Cu S -CuInS HNS, which inhibited the formation of the In(OH) phase due to the formation of the indium(iii)-citric acid complex. The formation mechanism was studied by monitoring the morphology and phase evolution of the Cu S -CuInS HNS with reaction time, which revealed that the Cu S seeds were first formed and then the cation-exchange reaction directed the subsequent anisotropic growth of the Cu S -CuInS HNS.
[Mh] Termos MeSH primário: Ácido Cítrico/química
Cobre/química
Índio/química
Óleos/química
Sulfetos/química
Água/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils); 0 (Sulfides); 045A6V3VFX (Indium); 059QF0KO0R (Water); 2968PHW8QP (Citric Acid); 789U1901C5 (Copper)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1039/c7dt04274d


  4 / 8627 MEDLINE  
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[PMID]:29272278
[Au] Autor:Brain MJ; Roodenburg OS; McNeil J
[Ad] Endereço:Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
[Ti] Título:Comparison of pre-filter and post-filter ionised calcium monitoring in continuous veno-venous hemodiafiltration (CVVHD-F) with citrate anti-coagulation.
[So] Source:PLoS One;12(12):e0189745, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It is widespread practice during citrate anticoagulated renal replacement therapy to monitor circuit ionised calcium (iCa2+) to evaluate the effectiveness of anticoagulation. Whether the optimal site to sample the blood path is before or after the haemofilter is a common question. METHODS: Using a prospectively collected observational dataset from intensive care patients receiving pre-dilution continuous veno-venous haemodiafiltration (CVVHD-F) with integrated citrate anticoagulation we compared paired samples of pre and post filter iCa2+ where the target range was 0.3-0.5 mmol.L-1 as well as concurrently collected arterial iCa2+. Two nested mixed methods linear models were fitted to the data describing post vs pre filter iCa2+, and the relationship of pre, post and arterial samples. SETTING: An 11 bed general intensive care unit. PARTICIPANTS: 450 grouped samples from 152 time periods in seven patients on CRRT with citrate anticoagulation. RESULTS: The relationship of post to pre-filter iCa2+ was not 1:1 with post = 0.082 + 0.751 x pre-filter iCa2+ (95% CI intercept: 0.015-0.152, slope 0.558-0.942). Variation was greatest between patients rather than between circuits within the same patient or citrate dose. Compared to arterial iCa2+ there was no significant difference between pre and post-filter sampling sites (F-value 0.047, p = 0.827). CONCLUSION: These results demonstrate that there is minimal difference between pre and post filter samples for iCa2+ monitoring of circuit anticoagulation in citrate patients relative to the arterial iCa2+ in CVVHD-F however compared to pre-filter sampling, post filter sampling has a flatter response and greater variation.
[Mh] Termos MeSH primário: Anticoagulantes/administração & dosagem
Cálcio/análise
Ácido Cítrico/administração & dosagem
Hemodiafiltração/métodos
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 2968PHW8QP (Citric Acid); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189745


  5 / 8627 MEDLINE  
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[PMID]:27770631
[Au] Autor:Guo J; Kim GB; Shan D; Kim JP; Hu J; Wang W; Hamad FG; Qian G; Rizk EB; Yang J
[Ad] Endereço:Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
[Ti] Título:Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives.
[So] Source:Biomaterials;112:275-286, 2017 01.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge in developing such adhesives was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent. Among the investigated formulations, the highest adhesion strength achieved (223.11 ± 15.94 kPa) was around 13 times higher than that of a commercially available fibrin glue (15.4 ± 2.8 kPa). In addition, dual-crosslinked (i.e. click crosslinking and mussel-inspired crosslinking) iCMBAs still preserved considerable antibacterial and antifungal capabilities that are beneficial for the bioadhesives used as hemostatic adhesives or sealants for wound management.
[Mh] Termos MeSH primário: Adesivos/administração & dosagem
Anti-Infecciosos/administração & dosagem
Fenômenos Fisiológicos Bacterianos/efeitos dos fármacos
Materiais Biomiméticos/síntese química
Bivalves/química
Ácido Cítrico/administração & dosagem
Ácido Cítrico/síntese química
[Mh] Termos MeSH secundário: Adesividade
Adesivos/química
Animais
Anti-Infecciosos/síntese química
Materiais Biomiméticos/administração & dosagem
Química Click/métodos
Desenho de Drogas
Teste de Materiais
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Adhesives); 0 (Anti-Infective Agents); 2968PHW8QP (Citric Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  6 / 8627 MEDLINE  
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[PMID]:29185591
[Au] Autor:Tuerdi B; Zuo L; Sun H; Wang K; Wang Z; Li G
[Ad] Endereço:Respiratory Intensive Care Units, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
[Ti] Título:Safety and efficacy of regional citrate anticoagulation in continuous blood purification treatment of patients with multiple organ dysfunction syndrome.
[So] Source:Braz J Med Biol Res;51(1):e6378, 2017 Nov 17.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to discuss the safety and efficacy of regional citrate anticoagulation (RCA) on continuous blood purification (CBP) during the treatment of multiple organ dysfunction syndrome (MODS). Thirty-five patients with MODS were divided into two groups: the local citrate anticoagulation (RCA) group, and the heparin-free blood purification (hfBP) group. The MODS severity was assessed according to Marshall's MODS score criteria. Blood coagulation indicators, blood pressure, filter lifespan, filter replacement frequency, anticoagulation indicators, and main metabolic and electrolyte indicators were analyzed and compared between RCA and hfBP groups. RCA resulted in lower blood pressure than hfBP. The filter efficacy in RCA treatment was longer than in the hfBP group. The blood clearance of creatine, blood urea nitrogen and uric acid was better in the RCA group. RCA also led to higher pH than hfBP. Neither treatment resulted in severe bleeding events. In addition, MODS score was positively correlated with prothrombin time and activated partial thromboplastin time but negatively correlated with platelet concentration. RCA is a safer and more effective method in CBP treatment; however, it could also lead to low blood pressure and blood alkalosis.
[Mh] Termos MeSH primário: Anticoagulantes/farmacologia
Citratos/farmacologia
Ácido Cítrico/farmacologia
Glucose/farmacologia
Hemofiltração/métodos
Insuficiência de Múltiplos Órgãos/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anticoagulantes/uso terapêutico
Coagulação Sanguínea/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Citratos/uso terapêutico
Ácido Cítrico/uso terapêutico
Feminino
Glucose/uso terapêutico
Hemorragia/induzido quimicamente
Heparina/farmacologia
Heparina/uso terapêutico
Seres Humanos
Masculino
Meia-Idade
Valores de Referência
Reprodutibilidade dos Testes
Fatores de Risco
Índice de Gravidade de Doença
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Citrates); 1Q73Q2JULR (sodium citrate); 2968PHW8QP (Citric Acid); 9005-49-6 (Heparin); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  7 / 8627 MEDLINE  
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[PMID]:28457369
[Au] Autor:Pertica N; Cicciarella L; Carraro A; Montin U; Violi P; Lupo A; Zaza G
[Ad] Endereço:Renal and Dialysis Unit, University Hospital of Verona, Verona, Italy. Electronic address: nicoletta.pertica@ospedaleuniverona.it.
[Ti] Título:Safety and Efficacy of Citrate Anticoagulation for Continuous Renal Replacement Therapy for Acute Kidney Injury After Liver Transplantation: A Single-Center Experience.
[So] Source:Transplant Proc;49(4):674-676, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute kidney injury (AKI) after liver transplantation (LT) is a frequent and serious complication. The incidence of AKI requiring continuous renal replacement therapy (CRRT) ranges from 10% to 30%. Kidney Disease: Improving Global Outcomes guidelines indicate the use of citrate as a locoregional anticoagulant drug for CRRT regardless of the patient's hemorrhagic risk. Despite this indication, however, the use of citrate is still under debate in patients with liver failure and/or LT owing to the potential risk of plasmatic citrate accumulation due to reduced liver clearance. The aim of this study was to evaluate the safety and efficacy of citrate as a locoregional anticoagulation drug in CRRT for AKI after LT. METHODS: A retrospective analysis was performed in patients with AKI after liver transplantation who were treated with CRRT using citrate as local anticoagulant. Five patients were enrolled from January to December 2015. RESULTS: No patients showed complications related to citrate (metabolic acidosis, hyperlactatemia, hypercalcemia, or hypernatremia). All treatments with heparin were stopped owing to circuit clotting. Treatments with citrate was interrupted where it was no longer needed or when other examinations had to be made. None were stopped because of circuit coagulation. CONCLUSIONS: At our center, 5 patients have been successfully treated with the use of CRRT with citrate for AKI during the post-LT course. Our results, though on a small series of patients, provide evidence that CRRT with citrate can be a safe and promising treatment for AKI after LT.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Lesão Renal Aguda/terapia
Anticoagulantes/uso terapêutico
Ácido Cítrico/uso terapêutico
Transplante de Fígado/efeitos adversos
Terapia de Substituição Renal/métodos
[Mh] Termos MeSH secundário: Coagulação Sanguínea/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 2968PHW8QP (Citric Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  8 / 8627 MEDLINE  
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[PMID]:28886192
[Au] Autor:Deng T; Mai Z; Cai C; Duan X; Zhu W; Zhang T; Wu W; Zeng G
[Ad] Endereço:Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
[Ti] Título:Influence of weight status on 24-hour urine composition in adults without urolithiasis: A nationwide study based on a Chinese Han population.
[So] Source:PLoS One;12(9):e0184655, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study sought to explore the influence of different body weight statuses on 24-hour urine compositions in adults without urolithiasis based on a nationwide study of a Chinese Han population. MATERIAL AND METHODS: Twenty-four-hour urine samples from 584 Chinese Han adults without urolithiasis in six cities were analyzed. The participants were divided into four body weight status types according to their body mass indices (BMIs) according to WHO guidelines. The baseline characteristics and 24-hour urine compositions of the standard weight group were compared with those of the underweight, overweight and obese groups. The influences of different body weight statuses on the 24-hour urine compositions were explored using univariate and multivariate logistic regressions. RESULTS: The numbers of participants in the underweight, standard weight, overweight and obese status groups were 24, 376, 149 and 35, respectively. The overweight and obese groups suffered significantly higher risks of hypertension and diabetes mellitus than the standard weight group. In the univariate analyses, compared with the standard weight group, the overweight group had significantly higher levels of urine citrate (mean difference [MD] = 0.51 mmol, 95% confidence interval [CI]: 0.15-0.87, P = 0.001), potassium (MD = 6.63 mmol, 95% CI: 1.13-12.14, P = 0.01) and magnesium (MD = 0.38 mmol, 95% CI: 0.08-0.69, P = 0.014). Significant increases in urine citrate (MD = 0.85 mmol, 95% CI: 0.01-1.68, P = 0.046), magnesium (MD = 0.69 mmol, 95% CI: 0.13-1.25, P = 0.016) and phosphate (MD = 2.28 mmol, 95% CI: 0.03-4.54, P = 0.047) were found in the obese group. No significant differences were detected between the standard weight and underweight groups. In the multivariate logistic regression analyses, we only observed significantly higher levels of urine potassium (odds ratio [OR] = 1.02, 95% CI: 1.00-1.04, P = 0.03) in the overweight group and phosphate (OR = 1.32, 95% CI: 1.05-1.66, P = 0.018) in the obese group when compared with the standard weight group. CONCLUSIONS: Nonstone-forming adults with overweight or obese statuses were at higher risks of hypertension and diabetes mellitus. Obese nonstone-formers might have a greater risk of urinary stone formation due to increased urinary phosphate excretion. Additionally, underweight status had no influence on 24-hour urine composition.
[Mh] Termos MeSH primário: Peso Corporal/fisiologia
Obesidade/urina
Sobrepeso/urina
Urolitíase/urina
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
Cálcio/urina
China
Ácido Cítrico/urina
Seres Humanos
Resistência à Insulina/fisiologia
Modelos Logísticos
Meia-Idade
Análise Multivariada
Oxalatos/urina
Sódio/urina
Ácido Úrico/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); 268B43MJ25 (Uric Acid); 2968PHW8QP (Citric Acid); 9NEZ333N27 (Sodium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184655


  9 / 8627 MEDLINE  
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[PMID]:28874460
[Au] Autor:Martin-Lorenzo M; Martinez PJ; Baldan-Martin M; Ruiz-Hurtado G; Prado JC; Segura J; de la Cuesta F; Barderas MG; Vivanco F; Ruilope LM; Alvarez-Llamas G
[Ad] Endereço:From the Department of Immunology, IIS-Fundacion Jimenez Diaz, REDinREN, Madrid, Spain (M.M.-L., P.J.M., F.V., G.A.-L.); Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos SESCAM, Toledo, Spain (M.B.-M., M.G.B.); Hypertension Unit, Instituto de Investigación imas12, Hospital U
[Ti] Título:Citric Acid Metabolism in Resistant Hypertension: Underlying Mechanisms and Metabolic Prediction of Treatment Response.
[So] Source:Hypertension;70(5):1049-1056, 2017 Nov.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Resistant hypertension (RH) affects 9% to 12% of hypertensive adults. Prolonged exposure to suboptimal blood pressure control results in end-organ damage and cardiovascular risk. Spironolactone is the most effective drug for treatment, but not all patients respond and side effects are not negligible. Little is known on the mechanisms responsible for RH. We aimed to identify metabolic alterations in urine. In addition, a potential capacity of metabolites to predict response to spironolactone was investigated. Urine was collected from 29 patients with RH and from a group of 13 subjects with pseudo-RH. For patients, samples were collected before and after spironolactone administration and were classified in responders (n=19) and nonresponders (n=10). Nuclear magnetic resonance was applied to identify altered metabolites and pathways. Metabolites were confirmed by liquid chromatography-mass spectrometry. Citric acid cycle was the pathway most significantly altered ( <0.0001). Metabolic concentrations were quantified and ranged from ng/mL malate to µg/mL citrate. Citrate and oxaloacetate increased in RH versus pseudoresistant. Together with α-ketoglutarate and malate, they were able to discriminate between responders and nonresponders, being the 4 metabolites increased in nonresponders. Combined as a prediction panel, they showed receiver operating characteristiccurve with area under the curve of 0.96. We show that citric acid cycle and deregulation of reactive oxygen species homeostasis control continue its activation after hypertension was developed. A metabolic panel showing alteration before spironolactone treatment and predicting future response of patients is shown. These molecular indicators will contribute optimizing the rate of control of RH patients with spironolactone.
[Mh] Termos MeSH primário: Ácido Cítrico
Resistência a Medicamentos/fisiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Hipertensão
Espironolactona
[Mh] Termos MeSH secundário: Idoso
Anti-Hipertensivos/administração & dosagem
Anti-Hipertensivos/efeitos adversos
Anti-Hipertensivos/farmacocinética
Cromatografia Líquida/métodos
Ácido Cítrico/análise
Ácido Cítrico/metabolismo
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/urina
Feminino
Seres Humanos
Hipertensão/tratamento farmacológico
Hipertensão/epidemiologia
Hipertensão/metabolismo
Ácidos Cetoglutáricos/análise
Ácidos Cetoglutáricos/metabolismo
Masculino
Meia-Idade
Valor Preditivo dos Testes
Prognóstico
Espanha/epidemiologia
Espironolactona/administração & dosagem
Espironolactona/efeitos adversos
Espironolactona/farmacocinética
Urinálise/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Ketoglutaric Acids); 27O7W4T232 (Spironolactone); 2968PHW8QP (Citric Acid); 8ID597Z82X (alpha-ketoglutaric acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.09819


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[PMID]:28857854
[Au] Autor:Faguer S; Saint-Cricq M; Nogier MB; Labadens I; Lavayssiere L; Kamar N; Cointault O
[Ad] Endereço:1Département de Néphrologie et Transplantation d'organes, Unité de Réanimation, CHU de Toulouse, Hôpital Rangueil, Toulouse, France. 2Université Toulouse-3, Toulouse, France. 3Institut National de la Santé et de la Recherche Médicale U1048 (équipe 12), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France. 4Pharmacology department, Unité de Pharmacie clinique, CHU de Toulouse, Toulouse, France.
[Ti] Título:Heparin-Free Prolonged Intermittent Hemodialysis Using Calcium-Free Citrate Dialysate in Critically Ill Patients.
[So] Source:Crit Care Med;45(11):1887-1892, 2017 Nov.
[Is] ISSN:1530-0293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Critically ill patients who have a high risk of bleeding but require prolonged intermittent dialysis need a heparin-free easy-to-use alternative type of anticoagulation within the dialysis circuit. We assessed the safety and efficiency of heparin-free regional citrate anticoagulation of the dialysis circuit using a calcium-free citrate-containing dialysate, with calcium reinjected according to ionic dialysance. DESIGN: Prospective cohort study. SETTING: Critical care units. PATIENTS: Critically ill patients who required renal replacement therapy. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 101 dialysis sessions were performed in 35 patients (mechanical ventilation n = 78; norepinephrine n = 13). Median duration of dialysis was 294 minutes (interquartile range, 240-300), and median ultrafiltration volume was 2.3 L (1-2.8). Urea and ß2-microglobulin reduction rates were 64.5% ± 0.4% and 48% ± 0.13%, respectively. Postfilter ionized calcium was 0.35 ± 0.17 and 0.38 ± 0.14 mmol/L at 1 and 3 hours, respectively, within the extracorporeal circuit. A major clotting event that led to premature termination of the session occurred in only three of 101 sessions. In these three cases, major catheter dysfunction occurred before clotting within the circuit. Prefilter ionized calcium remained within narrow ranges (before/after change +0.07 ± 0.006 mmol/L), and total-to-ionized calcium ratio, a surrogate marker for citratemia, was unchanged. CONCLUSIONS: Dialysis anticoagulation with calcium-free citrate-containing dialysate and calcium reinjection according to ionic dialysance is an easy-to-use, efficient, and inexpensive form of heparin-free regional anticoagulation. It allows prolonged hemodialysis sessions in critically ill patients without the need to systemically monitor ionized calcium. Furthermore, sessions can be safely extended according to the hemodynamic tolerance to ensure an adequate dose of dialysis and a negative water balance, a major point in patients with severe acute kidney disease.
[Mh] Termos MeSH primário: Ácido Cítrico/administração & dosagem
Estado Terminal/terapia
Soluções para Diálise/administração & dosagem
Soluções para Diálise/química
Diálise Renal/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Cloreto de Cálcio/administração & dosagem
Feminino
Heparina
Seres Humanos
Unidades de Terapia Intensiva
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Dialysis Solutions); 2968PHW8QP (Citric Acid); 9005-49-6 (Heparin); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/CCM.0000000000002694



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