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Pesquisa : D02.241.081.901.434.249.750 [Categoria DeCS]
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  1 / 230 MEDLINE  
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[PMID]:29240374
[Au] Autor:Goldfarb DS; Grasso M
[Ti] Título:Case Study - Case Studies in Cystinuria.
[So] Source:Urol Nurs;37(2):90-3, 2017 Mar-Apr.
[Is] ISSN:1053-816X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The diagnosis and treatment of patients with rare inherited metabolic disorders associated with recurrent and often obstructive kidney stones are important to the prevention of chronic kidney disease or end stage renal disease. Two case studies in this article describe the diagnosis and management of cystinuria, the most common rare kidney stone disorder.
[Mh] Termos MeSH primário: Cistinúria/diagnóstico
Íleo/transplante
Cálculos Renais/cirurgia
Ureter/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Cistinúria/complicações
Cistinúria/terapia
Dietoterapia
Diuréticos/uso terapêutico
Feminino
Hidratação
Seres Humanos
Cálculos Renais/etiologia
Masculino
Adesão à Medicação
Citrato de Potássio/uso terapêutico
Procedimentos Cirúrgicos Reconstrutivos
Insuficiência Renal Crônica/etiologia
Bicarbonato de Sódio
Tiopronina/uso terapêutico
Tomografia Computadorizada por Raios X
Ureteroscopia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); 8MDF5V39QO (Sodium Bicarbonate); C5W04GO61S (Tiopronin); EE90ONI6FF (Potassium Citrate)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  2 / 230 MEDLINE  
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[PMID]:29049166
[Au] Autor:Wang L; Cui Y; Zhang J; Zhang Q
[Ad] Endereço:Department of Nephropathy, The Second Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
[Ti] Título:Safety of potassium-bearing citrate in patients with renal transplantation: A case report.
[So] Source:Medicine (Baltimore);96(42):e6933, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Urinary lithiasis is one of severe postoperative complications in patients undergoing renal transplantation, possibly leading to anuria, urinary infection, or even acute renal failure. Potassium sodium hydrogen citrate (PSHC), a potassium-bearing citrate, is commonly prescribed to prevent stone formation. PATIENT CONCERNS: A 25-year-old man (patient 1) and a 31-year-old man (patient 2) receiving renal transplantation for end-stage renal disease (ESRD) were enrolled in this study. They were given 10 g/day of PSHC granules from the ninth day to the 17th day after surgery. Patient 1 presented chest tightness, nausea, muscle weakness, and ascending paralysis on the 10th day. Patient 2 presented weak waves on EGG on the 17th day. Moreover, their serum potassium concentrations (SPCs) were 7.67 and 6.05 mmol/L, respectively. DIAGNOSIS: Acute hyperkalemia. INTERVENTIONS: Hemo-filtration was performed for patient 1, while patient 2 received 10% calcium gluconate 10 mL, 5% NaHCO3 125 mL, and 10% glucose 500 mL with the addition of 10 units of insulin through intravenous drip. OUTCOMES: Their SPCs dropped to the normal range. LESSONS: Physicians should pay close attentions to potential risks caused by PSHC, and monitor the SPCs to minimize the occurrence of hyperkalemia.
[Mh] Termos MeSH primário: Diuréticos/efeitos adversos
Hiperpotassemia/induzido quimicamente
Complicações Pós-Operatórias/prevenção & controle
Citrato de Potássio/efeitos adversos
Urolitíase/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Diuréticos/administração & dosagem
Seres Humanos
Transplante de Rim/efeitos adversos
Masculino
Complicações Pós-Operatórias/etiologia
Citrato de Potássio/administração & dosagem
Urolitíase/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); EE90ONI6FF (Potassium Citrate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006933


  3 / 230 MEDLINE  
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[PMID]:28715463
[Au] Autor:Granchi D; Torreggiani E; Massa A; Caudarella R; Di Pompo G; Baldini N
[Ad] Endereço:Orthopedic Pathophysiology and Regenerative Medicine Unit, Rizzoli Orthopedic Institute, Bologna, Italy.
[Ti] Título:Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss.
[So] Source:PLoS One;12(7):e0181230, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the skeleton and the deterioration of bone microarchitecture. Alkalinization through supplementation with potassium citrate (K citrate) has been proposed to limit the osteopenia progression, even though its pharmacological activity in bone microenvironment is not well defined. We evaluated if K citrate was able to prevent the adverse effects that acidic milieu induces on bone cells. OC and OB were maintained in neutral (pH 7.4) versus acidic (pH 6.9) culture medium, and treated with different K citrate concentrations. We evaluated the OC differentiation at seven days, by counting of multinucleated cells expressing tartrate-resistant acid phosphatase, and the activity of mature OC at 14 days, by quantifying of collagen degradation. To evaluate the effects on OB, we analyzed proliferation, mineralization, and expression of bone-related genes. We found that the low pH increased OC differentiation and activity and decreased OB function. The osteoclastogenesis was also promoted by RANKL concentrations ineffective at pH 7.4. Non-cytotoxic K citrate concentrations were not sufficient to steadily neutralize the acidic medium, but a) inhibited the osteoclastogenesis, the collagen degradation, and the expression of genes involved in RANKL-mediated OC differentiation, b) enhanced OB proliferation and alkaline phosphatase expression, whereas it did not affect the in vitro mineralization, and c) were effective also in OC cultures resistant to alendronate, i.e. the positive control of osteoclastogenesis inhibition. In conclusion, K citrate prevents the increase in OC activity induced by the acidic microenvironment, and the effect does not depend exclusively on its alkalizing capacity. These data provide the biological basis for the use of K citrate in preventing the osteopenia progression resulting from low-grade acidosis.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/farmacologia
Concentração de Íons de Hidrogênio
Osteoblastos/efeitos dos fármacos
Osteoclastos/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Citrato de Potássio/farmacologia
[Mh] Termos MeSH secundário: Alendronato/farmacologia
Fosfatase Alcalina/metabolismo
Animais
Conservadores da Densidade Óssea/toxicidade
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Meios de Cultura/química
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
Camundongos
Osteoblastos/metabolismo
Osteoclastos/metabolismo
Osteogênese/fisiologia
Osteoporose Pós-Menopausa/tratamento farmacológico
Osteoporose Pós-Menopausa/metabolismo
Citrato de Potássio/toxicidade
Ligante RANK/metabolismo
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Culture Media); 0 (RANK Ligand); 0 (TNFSF11 protein, human); 0 (Tnfsf11 protein, mouse); EC 3.1.3.1 (Alkaline Phosphatase); EE90ONI6FF (Potassium Citrate); X1J18R4W8P (Alendronate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181230


  4 / 230 MEDLINE  
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[PMID]:28542241
[Au] Autor:Forni Ogna V; Blanchard A; Vargas-Poussou R; Ogna A; Baron S; Bertocchio JP; Prot-Bertoye C; Nevoux J; Dubourg J; Maruani G; Mendes M; Garcia-Castaño A; Treard C; Lepottier N; Houillier P; Courbebaisse M
[Ad] Endereço:Centre d'Investigations Cliniques, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
[Ti] Título:Signification of distal urinary acidification defects in hypocitraturic patients.
[So] Source:PLoS One;12(5):e0177329, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Hypocitraturia has been associated with metabolic acidosis and mineral disorders. The aim of this study was to investigate the occurrence of urinary acidification defects underlying hypocitraturia. MATERIALS AND METHODS: This retrospective observational study included 67 patients (32 men), aged 40.7±15.1 years with hypocitraturia (<1.67 mmol/24-h) and nephrolithiasis, nephrocalcinosis, and/or bone demineralization, referred to our center from 2000 to 2015. We aimed to assess renal distal acidification capacity, prevalence and mechanisms of urinary acidification defects. Patients with low baseline plasma HCO3- (<22 mmol/L) were studied by bicarbonate loading or furosemide/fludrocortisone tests. Patients with normal baseline plasma HCO3- had an ammonium-chloride challenge test. A normal response was a decrease in urinary pH <5.3 and an increase in urinary NH4+ ≥33 µmol/min and defined idiopathic hypocitraturia. RESULTS: Eleven patients (16.4%) had low HCO3- and overt distal acidification defect. Three had a mutation in the gene encoding AE1, 4 had Gougerot-Sjögren syndrome and no cause was found in the remaining 4 cases. Fifty-six patients (83.6%) had normal HCO3-; of those, 33 (58.9%) had idiopathic hypocitraturia. Among the 23 (41%) remaining patients, 12 were unable to increase urinary NH4+ excretion (among them, 8 were able to decrease urinary pH and 4 were not) whereas 11 were able to increase urinary NH4+ excretion but unable to decrease urinary pH. These 11 patients had higher fasting urinary calcium, reflecting bone resorption, than the other 12 patients: median 0.41 [0.24-0.47] vs. 0.22 [0.08-0.37] mmol/mmol creatinine (P = 0.04). CONCLUSIONS: Patients with hypocitraturia and normal plasma HCO3- frequently show a latent acidification defect that can be further dissected into one of several subtypes based on urinary pH and NH4+ response to the acid load. Those patients with impaired urine acidification capacity but preserved NH4+ excretion exhibit particularly high calciuria and should be identified to optimize nephrolithiasis prevention.
[Mh] Termos MeSH primário: Citrato de Potássio/urina
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Rim/metabolismo
Masculino
Meia-Idade
Citrato de Potássio/metabolismo
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EE90ONI6FF (Potassium Citrate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177329


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[PMID]:28213035
[Au] Autor:Liato V; Hammami R; Aïder M
[Ad] Endereço:Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, QC, G1V 0A6, Canada; Department of Soil Sciences and Agri-Food Engineering, Université Laval, Quebec, QC, G1V 0A6, Canada.
[Ti] Título:Influence of electro-activated solutions of weak organic acid salts on microbial quality and overall appearance of blueberries during storage.
[So] Source:Food Microbiol;64:56-64, 2017 Jun.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to study the potential of diluted electro-activated solutions of weak organic acid salts (potassium acetate, potassium citrate and calcium lactate) to extend the shelf life of blueberries during post-harvest storage. The sanitizing capacity of these solutions was studied against pathogenic bacteria Listeria monocytogenes and E. coli O157:H7 as well as phytopathogenic fungi A. alternata, F. oxysporum and B. cinerea. The results showed that a 5-min treatment of inoculated blueberries with electro-activated solutions resulted in a 4 log CFU/g reduction in Listeria monocytogenes for all solutions. For E. coli O157:H7, the electro-activated potassium acetate and potassium citrate solutions achieved a decrease of 3.5 log CFU/g after 5 min of berry washing. The most important fungus reduction was found when blueberries were washed with an electro-activated solution of potassium acetate and a NaOCl solution. After 5 min of blueberry washing with an electro-activated potassium acetate solution, a very high reduction effect was observed for A. alternata, F. oxysporum and B. cinerea, which showed survival levels of only 2.2 ± 0.16, 0.34 ± 0.15 and 0.21 ± 0.16 log CFU/g, respectively. Regarding the effect of the washing on the organoleptic quality of blueberries, the obtained results showed no negative effect on the product color or textural profile. Finally, this work suggests that washing with electro-activated solutions of weak organic acid salts can be used to enhance the shelf-life of blueberries during post-harvest storage.
[Mh] Termos MeSH primário: Mirtilos Azuis (Planta)/microbiologia
Ácidos Carboxílicos/farmacologia
Escherichia coli O157/efeitos dos fármacos
Qualidade dos Alimentos
Armazenamento de Alimentos/métodos
Fungos/efeitos dos fármacos
Listeria monocytogenes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Mirtilos Azuis (Planta)/efeitos dos fármacos
Compostos de Cálcio/farmacologia
Ácidos Carboxílicos/química
Contagem de Colônia Microbiana
Desinfetantes/farmacologia
Microbiologia de Alimentos
Lactatos/farmacologia
Acetato de Potássio/farmacologia
Citrato de Potássio/farmacologia
Hipoclorito de Sódio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Compounds); 0 (Carboxylic Acids); 0 (Disinfectants); 0 (Lactates); 2URQ2N32W3 (calcium lactate); DY38VHM5OD (Sodium Hypochlorite); EE90ONI6FF (Potassium Citrate); M911911U02 (Potassium Acetate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28247720
[Au] Autor:Popkov VM; Usanov DA; Rebrov VG; Usanov AD; Verkhov DG; Bulanov VM
[Ad] Endereço:Saratov State Medical University named after V.I. Razumovsky.
[Ti] Título:[The influence of alternating magnetic field on in vitro litholysis of uroliths in blemaren water solutions].
[So] Source:Urologiia;(4):15-18, 2016 Aug.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:THE AIM OF THE RESEARCH: increase of efficiency of urolith in vitro solution using water Blemaren medication solutions after their exposure to 2 Hz alternating magnetic field. MATERIALS AND METHODS: water solution of Blemaren medication with pH=6,15 in concentrations corresponding to single portion of medication (1 tablet m=3,5282 g per 250 ml of water) and uroliths (oxalates, urates including uncommon xanthine calculi). Composition of calculi was determined by means of X-ray tests and IR spectroscopy. Photometry of Blemaren with saluted portion of calculi was conducted. RESULTS: it was established that in the Blemaren solutions which had been previously exposed to 2 Hz alternating magnetic filed during one hour the solution process is 1.92 - 2 times more effective than in common water solutions. Discussion - in control solutions pH values increased 5.65 - 6.8 times in the course of time, whereas in the Blemaren solutions exposed to alternating magnetic field pH values remained virtually unaltered during the whole experiment. CONCLUSION: there were detected significant differences in pH values of Blemaren solutions and its solvent properties between solutions which were exposed to alternating magnetic filed and those which were not.
[Mh] Termos MeSH primário: Citratos/química
Campos Magnéticos
Cálculos da Bexiga Urinária/química
[Mh] Termos MeSH secundário: Seres Humanos
Técnicas In Vitro
Citrato de Potássio/química
Soluções
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Solutions); 059QF0KO0R (Water); EE90ONI6FF (Potassium Citrate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


  7 / 230 MEDLINE  
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[PMID]:28073210
[Au] Autor:Barbera M; Tsirgiotis A; Barbera M; Paola Q
[Ad] Endereço:Operative Unit of Urology, Ospedale Giovanni Paolo II, Sciacca. barbera.mic@gmail.com.
[Ti] Título:The importance of citrates in treatment and prophylaxis of calcium oxalate urinary stones.
[So] Source:Arch Ital Urol Androl;88(4):343-344, 2016 Dec 30.
[Is] ISSN:1124-3562
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:About 10% of the people is the subject of an episode of kidney stones during their lifetime, about 70% of these people undergoes relapses. About 80% of the urinary stones contains calcium, of wich 80% is formed of calcium oxalate, in pure form or associated with calcium phosphate. Therefore we can saythat in most cases (about 65%) the urinary stones are composedof calcium oxalate. Use of supplements of potassium citrate and magnesium citrate can help in the prevention of kidney stones of calcium oxalate, but mostly they can be used in the days before a shockwaves lithotripsy treatment to make the stones more fragile to the effect of the shock waves. A case of successful treatment with magnesium potassium citrate of a SWL resistant ureteral stone is presented.
[Mh] Termos MeSH primário: Oxalato de Cálcio
Ácido Cítrico/uso terapêutico
Compostos Organometálicos/uso terapêutico
Citrato de Potássio/uso terapêutico
Cálculos Ureterais/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Oxalato de Cálcio/análise
Seres Humanos
Masculino
Cálculos Ureterais/química
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 2612HC57YE (Calcium Oxalate); 2968PHW8QP (Citric Acid); EE90ONI6FF (Potassium Citrate); RHO26O1T9V (magnesium citrate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.4081/aiua.2016.4.343


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[PMID]:28073209
[Au] Autor:Barbera M; Tsirgiotis A; Barbera M; Paola Q
[Ad] Endereço:Operative Unit of Urology, Ospedale Giovanni Paolo II, Sciacca. barbera.mic@gmail.com.
[Ti] Título:The importance of potassium citrate and potassium bicarbonate in the treatment of uric acid renal stones.
[So] Source:Arch Ital Urol Androl;88(4):341-342, 2016 Dec 30.
[Is] ISSN:1124-3562
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Uric acid calculi can also be treated without surgery, with simple medical lytic therapy. After appropriate dietary adjustments and add of mineral water, the needed amount of alkali supplementation can increase pH values of the urine in order to dissolve the stones. Treatment should be prolonged to prevent stone recurrence. A case of bilateral renal uric acid stones that were successfully treated by alakalizing treatment was presented.
[Mh] Termos MeSH primário: Bicarbonatos/uso terapêutico
Cálculos Renais/tratamento farmacológico
Citrato de Potássio/uso terapêutico
Compostos de Potássio/uso terapêutico
Ácido Úrico
[Mh] Termos MeSH secundário: Seres Humanos
Cálculos Renais/química
Masculino
Meia-Idade
Ácido Úrico/análise
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Potassium Compounds); 268B43MJ25 (Uric Acid); EE90ONI6FF (Potassium Citrate); HM5Z15LEBN (potassium bicarbonate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.4081/aiua.2016.4.341


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[PMID]:27448942
[Au] Autor:Vongpatanasin W; Peri-Okonny P; Velasco A; Arbique D; Wang Z; Ravikumar P; Adams-Huet B; Moe OW; Pak CYC
[Ad] Endereço:Cardiology Division Hypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
[Ti] Título:Effects of Potassium Magnesium Citrate Supplementation on 24-Hour Ambulatory Blood Pressure and Oxidative Stress Marker in Prehypertensive and Hypertensive Subjects.
[So] Source:Am J Cardiol;118(6):849-853, 2016 Sep 15.
[Is] ISSN:1879-1913
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diet rich in fruits, vegetables, and dairy products, known as the Dietary Approaches to Stop Hypertension (DASH) diet, is known to reduce blood pressure (BP) in hypertensive patients. More recently, the DASH diet was shown to reduce oxidative stress in hypertensive and nonhypertensive humans. However, the main nutritional components responsible for these beneficial effects of the DASH diet remain unknown. Because the DASH diet is rich in potassium (K), magnesium (Mg), and alkali, we performed a randomized, double-blinded, placebo-controlled study to compare effects of potassium magnesium citrate (KMgCit), potassium chloride (KCl), and potassium citrate (KCit) to allow dissociation of the three components of K, Mg, and citrate on 24-hour ambulatory BP and urinary 8-isoprostane in hypertensive and prehypertensive subjects, using a randomized crossover design. We found that KCl supplementation for 4 weeks induced a significant reduction in nighttime SBP compared with placebo (116 ± 12 vs 121 ± 15 mm Hg, respectively, p <0.01 vs placebo), whereas KMgCit and KCit had no significant effect in the same subjects (118 ± 11 and 119 ± 13 mm Hg, respectively, p >0.1 vs placebo). In contrast, urinary 8-isoprostane was significantly reduced with KMgCit powder compared with placebo (13.5 ± 5.7 vs 21.1 ± 10.5 ng/mgCr, respectively, p <0.001), whereas KCl and KCit had no effect (21.4 ± 9.1 and 18.3 ± 8.4, respectively, p >0.1 vs placebo). In conclusion, our study demonstrated differential effects of KCl and KMgCit supplementation on BP and the oxidative stress marker in prehypertensive and hypertensive subjects. Clinical significance of the antioxidative effect of KMgCit remains to be determined in future studies.
[Mh] Termos MeSH primário: Citratos/uso terapêutico
Hipertensão/tratamento farmacológico
Compostos de Magnésio/uso terapêutico
Estresse Oxidativo
Cloreto de Potássio/uso terapêutico
Citrato de Potássio/uso terapêutico
Compostos de Potássio/uso terapêutico
Pré-Hipertensão/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Anti-Hipertensivos/uso terapêutico
Pressão Sanguínea
Monitorização Ambulatorial da Pressão Arterial
Estudos Cross-Over
Suplementos Nutricionais
Dinoprosta/análogos & derivados
Dinoprosta/urina
Método Duplo-Cego
Combinação de Medicamentos
Feminino
Seres Humanos
Hipertensão/metabolismo
Modelos Lineares
Masculino
Meia-Idade
Potássio/metabolismo
Pré-Hipertensão/metabolismo
Rigidez Vascular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Citrates); 0 (Drug Combinations); 0 (Magnesium Compounds); 0 (Potassium Compounds); 27415-26-5 (8-epi-prostaglandin F2alpha); 660YQ98I10 (Potassium Chloride); B7IN85G1HY (Dinoprost); EE90ONI6FF (Potassium Citrate); RWP5GA015D (Potassium); TRI2520XBJ (potassium-magnesium citrate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27215244
[Au] Autor:Abouzeid SM; ElHossary HE
[Ad] Endereço:Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt.
[Ti] Título:Na/K citrate versus sodium bicarbonate in prevention of contrast-induced nephropathy.
[So] Source:Saudi J Kidney Dis Transpl;27(3):519-25, 2016 May.
[Is] ISSN:1319-2442
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:Contrast-induced nephropathy (CIN) is one of the important complications of radiographic procedures, especially in patients with chronic kidney disease. It is also one of the common causes of acute kidney injury. The pathogenesis is postulated to be the effect of oxygen- free radicals and hyperosmolar stress on the renal medulla. It is reported that the production of superoxide is most active at acid environment. K/Na citrate is well known as a urine alkalinization medium, and this has been evaluated earlier with standard hydration for reduction of CIN and was stated to be efficient. We aimed to determine the efficacy of Na/K citrate in reducing the frequency of CIN in comparison to sodium bicarbonate in patients after coronary angiography. Two hundred and ten patients with renal dysfunction [estimated glomerular filtration rate (eGFR), 60 mL/min/1.73 m(2) or less] who underwent elective or emergency coronary angiography (CAG) with/without percutaneous coronary intervention (PCI) at our institution were enrolled into the study. The patients were randomized into two groups, Group 1-Taking Na/K citrate and Group 2-Taking sodium bicarbonate. Radiographic contrast agent iohexol was used. Change in creatinine, percent change in creatinine, percent change in eGFR, change in serum potassium, and urine pH were all compared between the two groups. There was no significant difference for prevention of CIN when comparing the Na/K citrate with sodium bicarbonate solution in patients exposed to CAG with or without PCI. Mean absolute change in eGFR after 48 h after administration of contrast between sodium bicarbonate group and Na/K citrate group was -0.60 ± 1.58 versus -0.71 ± 1.38. Serum potassium decreased postprocedure in the sodium bicarbonate group than in the citrate group (3.90 ± 0.33 vs. 4.14 ± 0.39). Both agents are equally effective in reducing the incidence of CIN, but the citrate would possibly be a safer option for patients at risk of hypokalemia.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Lesão Renal Aguda/prevenção & controle
Citratos/uso terapêutico
Meios de Contraste/efeitos adversos
Citrato de Potássio/uso terapêutico
Bicarbonato de Sódio/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Citrates); 0 (Contrast Media); 1Q73Q2JULR (sodium citrate); 8MDF5V39QO (Sodium Bicarbonate); EE90ONI6FF (Potassium Citrate)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160524
[Lr] Data última revisão:
160524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE
[do] DOI:10.4103/1319-2442.182386



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