Base de dados : MEDLINE
Pesquisa : D02.241.223 [Categoria DeCS]
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[PMID]:27814951
[Au] Autor:Gumbi BP; Moodley B; Birungi G; Ndungu PG
[Ad] Endereço:University of KwaZulu-Natal, School of Chemistry and Physics, Private Bag x 54001, Durban 4000, South Africa.
[Ti] Título:Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry.
[So] Source:Chemosphere;168:1042-1050, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A method was optimized for derivatization, separation, detection and quantification of salicylic acid, acetylsalicylic acid, nalidixic acid, ibuprofen, phenacetin, naproxen, ketoprofen, meclofenamic acid and diclofenac in surface water using gas chromatography-mass spectrometry. For most of the acidic drugs, recovery was in the range 60-110% and the percent standard deviation was below 15% for the entire method, with limits of detection ranging from 0.041 to 1.614 µg L . The developed method was applied in the analysis of acidic drugs in Umgeni River system, KwaZulu-Natal South Africa. All of the selected acidic drugs were detected and quantified, their concentration in Umgeni River system ranged from 0.0200 to 68.14 µg L .
[Mh] Termos MeSH primário: Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/análise
Aspirina/análise
Monitoramento Ambiental
Cromatografia Gasosa-Espectrometria de Massas/métodos
Concentração de Íons de Hidrogênio
Ácido Nalidíxico/análise
Naproxeno/análise
Fenacetina/análise
Rios/química
África do Sul
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 3B91HWA56M (Nalidixic Acid); 57Y76R9ATQ (Naproxen); ER0CTH01H9 (Phenacetin); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:27494565
[Au] Autor:Xu G; Singh S; Barnaby J; Buyer J; Reddy V; Sicher R
[Ad] Endereço:Crop Systems and Climate Change Laboratory, U.S.D.A.-Agricultural Research Service, Room 342, Building 001, BARC-west, 10300 Baltimore Avenue, Beltsville, MD 20705, USA.
[Ti] Título:Effects of growth temperature and carbon dioxide enrichment on soybean seed components at different stages of development.
[So] Source:Plant Physiol Biochem;108:313-322, 2016 Nov.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Soybean plants were grown to maturity in controlled environment chambers and at the onset of flowering three temperature treatments were imposed that provided optimum [28/24 °C], low [22/18 °C] or high [36/32 °C] chamber air temperatures. In addition, plants were treated continuously with either 400 or 800 µmol mol CO . Seeds were harvested at 42, 53, 69 and 95 days after planting (i.e., final maturity). This study quantified 51 metabolites in developing soybean seeds, plus total lipids and proteins were measured at maturity. About 80% of measured soluble carbohydrates, amines and organic acids decreased to low levels in mature seeds, although important exceptions were raffinose, ribose/arabinose, citrate and all eight fatty acids. This suggested that the metabolism of young seeds supported lipid and protein synthesis. A total of 35 and 9 metabolites differed among temperature and CO treatments, respectively, and treatment effects were predominately observed on the first and second samplings. However, shikimate, pinitol and oleate were increased by high temperature treatments in mature seeds. The above results indicated that CO enrichment primarily altered metabolite levels during the initial stages of seed development and this was likely due to enhanced photosynthate formation in leaves.
[Mh] Termos MeSH primário: Dióxido de Carbono
Sementes/crescimento & desenvolvimento
Sementes/metabolismo
Feijão de Soja/crescimento & desenvolvimento
Feijão de Soja/metabolismo
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/metabolismo
Aminoácidos/química
Metabolismo dos Carboidratos
Carboidratos/química
Ácido Cítrico/metabolismo
Ácidos Graxos/metabolismo
Metabolismo dos Lipídeos
Folhas de Planta/fisiologia
Proteínas de Plantas/metabolismo
Ácido Chiquímico/metabolismo
Solubilidade
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Amino Acids); 0 (Carbohydrates); 0 (Fatty Acids); 0 (Plant Proteins); 142M471B3J (Carbon Dioxide); 2968PHW8QP (Citric Acid); 29MS2WI2NU (Shikimic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170813
[Lr] Data última revisão:
170813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


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[PMID]:27041308
[Au] Autor:Su L; Hong R; Guo X; Wu J; Xia Y
[Ad] Endereço:State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Biotechnology and Key Laboratory of Industrial Biotechnology Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China.
[Ti] Título:Short-chain aliphatic ester synthesis using Thermobifida fusca cutinase.
[So] Source:Food Chem;206:131-6, 2016 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Short-chain aliphatic esters are commonly used as fruit flavorings in the food industry. In this study, Thermobifida fusca (T. fusca) cutinase was used for the synthesis of aliphatic esters, and the maximum yield of ethyl caproate reached 99.2% at a cutinase concentration of 50U/ml, 40°C, and water content of 0.5%, representing the highest ester yield to date. The cutinase-catalyzed esterification displayed strong tolerance for water content (up to 8%) and acid concentration (up to 0.8M). At substrate concentrations ⩽0.8M, the ester yield remained above 80%. Moreover, ester yields of more than 98% and 95% were achieved for acids of C3-C8 and alcohols of C1-C6, respectively, indicating extensive chain length selectivity of the cutinase. These results demonstrate the superior ability of T. fusca cutinase to catalyze the synthesis of short-chain esters. This study provides the basis for industrial production of short-chain esters using T. fusca cutinase.
[Mh] Termos MeSH primário: Actinobacteria/enzimologia
Hidrolases de Éster Carboxílico/metabolismo
Ésteres/metabolismo
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/metabolismo
Álcoois/metabolismo
Proteínas de Bactérias/metabolismo
Esterificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Alcohols); 0 (Bacterial Proteins); 0 (Esters); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.- (cutinase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


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[PMID]:26890088
[Au] Autor:Kim MS; Jin JS; Kwak YS; Hwang GS
[Ad] Endereço:Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute , Seoul 120-140, Republic of Korea.
[Ti] Título:Metabolic Response of Strawberry (Fragaria x ananassa) Leaves Exposed to the Angular Leaf Spot Bacterium (Xanthomonas fragariae).
[So] Source:J Agric Food Chem;64(9):1889-98, 2016 Mar 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants have evolved various defense mechanisms against biotic stress. The most common mechanism involves the production of metabolites that act as defense compounds. Bacterial angular leaf spot disease (Xanthomonas fragariae) of the strawberry (Fragaria x ananassa) has become increasingly destructive to strawberry leaves and plant production. In this study, we examined metabolic changes associated with the establishment of long-term bacterial disease stress using UPLC-QTOF mass spectrometry. Infected leaves showed decreased levels of gallic acid derivatives and ellagitannins, which are related to the plant defense system. The levels of phenylalanine, tryptophan, and salicylic acid as precursors of aromatic secondary metabolites were increased in inoculated leaves, whereas levels of coumaric acid, quinic acid, and flavonoids were decreased in infected plants, which are involved in the phenylpropanoid pathway. In addition, phenylalanine ammonia-lyase (PAL) activity, a key enzyme in the phenylpropanoid pathway, was decreased following infection. These results suggest that long-term bacterial disease stress may lead to down-regulation of select molecules of the phenylpropanoid metabolic pathway in strawberry leaves. This approach could be applied to explore the metabolic pathway associated with plant protection/breeding in strawberry leaves.
[Mh] Termos MeSH primário: Fragaria/metabolismo
Fragaria/microbiologia
Doenças das Plantas/microbiologia
Folhas de Planta/metabolismo
Folhas de Planta/microbiologia
Xanthomonas
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/análise
Resistência à Doença
Flavonoides/análise
Ácido Gálico/análise
Taninos Hidrolisáveis/análise
Fenilalanina Amônia-Liase/metabolismo
Folhas de Planta/química
Ácido Salicílico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Flavonoids); 0 (Hydrolyzable Tannins); 632XD903SP (Gallic Acid); EC 4.3.1.24 (Phenylalanine Ammonia-Lyase); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b05201


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[PMID]:26304344
[Au] Autor:Fu Q; Zhang C; Lin Z; Sun H; Liang Y; Jiang H; Song Z; Wang H; Chen S
[Ad] Endereço:School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: echo.huisheng@163.com.
[Ti] Título:Rapid screening and identification of compounds with DNA-binding activity from Folium Citri Reticulatae using on-line HPLC-DAD-MS(n) coupled with a post column fluorescence detection system.
[So] Source:Food Chem;192:250-9, 2016 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To study the interactions between natural compounds and deoxyribonucleic acid (DNA), a method has been established combining a high-performance liquid chromatography-diode array detector-multi-stage mass spectrometer with a fluorescence detector (HPLC-DAD-MS(n)-FLD). The FLD was used to monitor fluorescence intensity of the ethidium bromide-DNA (EB-DNA) complex when a compound separated by HPLC was introduced. This novel method was used to simultaneously obtain the HPLC fingerprint, UV spectra, MS(n) fragments and DNA-binding activity profile of various components in Folium Citri Reticulatae. As a result, 35 compounds were identified, of which 25 were found in the extract of Folium Citri Reticulatae for the first time, and 33 compounds showed DNA-binding activities, with the most active being feruloylhexaric and p-coumaroylhexaric acids. In addition, the precision, stability and reproducibility of this method were validated by two positive controls, quercetin and hesperidin. This new on-line method is accurate, precise and reliable for further high-throughput screening of DNA-binding compounds from food samples and other complex matrices.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Citrus/química
DNA/química
Flavonoides/análise
Fluorescência
Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/análise
Ácidos Carbocíclicos/química
Flavonoides/química
Hesperidina/análise
Modelos Lineares
Extratos Vegetais/química
Folhas de Planta/química
Quercetina/análise
Padrões de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Flavonoids); 0 (Plant Extracts); 9007-49-2 (DNA); 9IKM0I5T1E (Quercetin); E750O06Y6O (Hesperidin)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150825
[Lr] Data última revisão:
150825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150826
[St] Status:MEDLINE


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[PMID]:26613959
[Au] Autor:Ghasemzadeh A; Jaafar HZ; Rahmat A
[Ad] Endereço:Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. alighasemzadeh@upm.edu.my.
[Ti] Título:Phytochemical constituents and biological activities of different extracts of Strobilanthes crispus (L.) Bremek leaves grown in different locations of Malaysia.
[So] Source:BMC Complement Altern Med;15(1):422, 2015 Nov 27.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Strobilanthes crispus is a well-known herb in Malaysia with various pharmaceutical properties. S. crispus is known to contain several biologically active chemical constituents which are responsible for its pharmaceutical quality. METHODS: Strobilanthes crispus leaves grown in three different locations in Malaysia [Kelantan (North-east), Selangor (Central), and Penang (North)], were investigated for differences in the content of secondary metabolites [total phenolics content (TPC), total flavonoids content (TFC), and total saponins content (TSC)] as well as for their antioxidant and anticancer properties. Phenolic acids and flavonoids were identified using ultra-high performance liquid chromatography (UHPLC). Ferric reducing antioxidant potential (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays were used to evaluate the antioxidant activities. The anticancer activity of extracts against HeLa cancer cell line was evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. RESULTS: Samples from the three different locations when extracted with two solvents (aqueous and ethanol extracts) yielded significantly different results for TPC, TFC, and TSC as well as for antioxidant activity. Aqueous extract of S. crispus leaves collected from Kelantan exhibited the highest values: TPC [12.62 mg gallic acid equivalents (GAE)/g dry matter (DM)], TFC (7.44 mg quercetin equivalents (QE)/g DM), TSC (44.7 mg diosgenin equivalents (DE)/g DM), DPPH (73.8 %), and FRAP (267.5 µM of Fe (II)/g) activity with a half-maximal inhibitory concentration (IC50) of 44.1 µg/mL compared to the extracts of leaves collected from the other two locations. The most important secondary metabolites identified in this study, based on concentration, were phenolics classified as followed: caffeic acid>ferulic acid>gallic acid>chlorogenic acid>trans-cinnamic acid; flavonoids: quercetin>rutin>catechin>apigenin>naringenin>kaempferol. Extracts of leaves collected from Kelantan exhibited better anticancer activity against HeLa cancer cell line with an IC50 of 182.5 µg/mL compared to the extracts of leaves from Selangor (IC50 = 266.4 µg/mL) and Penang (IC50 = 331.5 µg/mL) and to tamoxifen (IC50 = 63.4 µg/mL). S. crispus leaves with the highest content of secondary metabolites exhibited the most potent antioxidant and anticancer activity. CONCLUSIONS: Therefore, based on the potent antioxidant and anticancer activity of leaves extracts, it appears that S. crispus grown in the North-east of Malaysia (Kelantan) is a potential source of anticarcinogenic therapeutic compounds.
[Mh] Termos MeSH primário: Acanthaceae
Antineoplásicos/farmacologia
Antioxidantes/farmacologia
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Acanthaceae/química
Ácidos Carbocíclicos/análise
Ácidos Carbocíclicos/farmacologia
Antineoplásicos/análise
Antioxidantes/análise
Linhagem Celular/efeitos dos fármacos
Flavonoides/análise
Flavonoides/farmacologia
Células HeLa/efeitos dos fármacos
Seres Humanos
Malásia
Compostos Fitoquímicos/análise
Extratos Vegetais/análise
Saponinas/análise
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Saponins)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0873-3


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[PMID]:25939096
[Au] Autor:Dong G; Xu J; Gu Y; Wei Y
[Ad] Endereço:State Key Laboratory of Chemical Resource Engineering, Beijing University Of Chemical Technology, No. 15 3rd North East Road, Chaoyang District, Beijing 100029, China.
[Ti] Título:A general separation method of phenolic acids using pH-zone-refining counter-current chromatography and its application to oat bran.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;992:36-42, 2015 Jun 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:pH-zone-refining counter-current chromatography technique for the separation of natural and synthetic mixtures has been widely used, especially for organic acids and alkaloids. Phenolic acids are very important compounds due to the potential treatment for a wide variety of diseases. However, there is not a general method for their separation. In this work, the conditions of pH-zone-refining counter-current chromatography, involving solvent systems, concentration of retainer and eluter, flow rate of mobile phase as well as sample pretreatment, were optimized to improve extraction efficiency and reduce separation time. Finally a general separation method for seven common phenolic acids has been established using pH-zone-refining counter-current chromatography. The separation of these phenolic acids was performed with a two-phase solvent system composed of methyl tert-butyl ether/acetonitrile/water at a volume ratio of 4.75: 0.25: 5, where 3mM trifluoroacetic acid was added to the organic stationary phase as a retainer and 3mM NH4OH was added to the aqueous mobile phase as an eluter. As a result, seven phenolic acids, including syringic acid, 4-hydroxyphenylacetic acid, vanillic acid, caffeic acid, p-hydroxybenzoic acid, ferulic acid and p-coumaric acid were successfully separated with the purities of 95.9%, 67.3%, 96.9%, 82.4%, 97.0%, 91.0%, and 97.2%, respectively. The established general method has been applied to the crude sample of oat bran pretreated with AB-8 resin. A total of 49.5mg of syringic acid, 109.2mg of p-coumaric acid and 184.5mg of ferulic acid were successfully purified in one run from 1.22g crude extract with the purities of 95.2%, 93.0%, and 91.8%, respectively.
[Mh] Termos MeSH primário: Ácidos Carbocíclicos/análise
Ácidos Carbocíclicos/isolamento & purificação
Avena/química
Distribuição Contracorrente/métodos
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/química
Cromatografia Líquida de Alta Pressão
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Plant Extracts)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150524
[Lr] Data última revisão:
150524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150505
[St] Status:MEDLINE


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[PMID]:25521719
[Au] Autor:Ramamurthy V; Jockusch S; Porel M
[Ad] Endereço:†Department of Chemistry, University of Miami, Coral Gables, Florida 33146, United States.
[Ti] Título:Supramolecular Photochemistry in Solution and on Surfaces: Encapsulation and Dynamics of Guest Molecules and Communication between Encapsulated and Free Molecules.
[So] Source:Langmuir;31(20):5554-70, 2015 May 26.
[Is] ISSN:1520-5827
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Supramolecular assemblies that help to preorganize reactant molecules have played an important role in the development of concepts related to the control of excited-state processes. This has led to a persistent search for newer supramolecular systems (hosts), and this review briefly presents our work with octa acid (OA) to a host to control excited-state processes of organic molecules. Octa acid, a water-soluble host, forms 1:1, 2:1, and 2:2 (host-guest) complexes with various organic molecules. A majority of the guest molecules are enclosed within a capsule made up of two molecules of OA whereas OA by itself remains as a monomer or aggregates. Luminescence and (1)H NMR spectroscopy help to characterize the structure and dynamics of these host-guest complexes. The guest molecule as well as the host-guest complex as a whole undergoes various types of motion, suggesting that the guests possess freedom inside the confined space of the octa acid capsule. In addition, the confined guests are not isolated but are able to communicate (energy, electron, and spin) with molecules present closer to the capsule. The host-guest complexes are stable even on solid surfaces such as silica, clay, α-Zr phosphate, TiO2, and gold nanoparticles. This opens up new opportunities to explore the interaction between confined guests and active surfaces of TiO2 and gold nanoparticles. In addition, this allows the possibility of performing energy and electron transfer between organic molecules that do not adsorb on inert surfaces of silica, clay, or α-Zr phosphate. The results summarized here, in addition to providing a fundamental understanding of the behavior of molecules in a confined space provided by the host OA, are likely to have a long-range effect on the capture and release of solar energy.
[Mh] Termos MeSH primário: Ácidos Carbocíclicos/química
Modelos Cardiovasculares
Processos Fotoquímicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Acids, Carbocyclic)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150526
[Lr] Data última revisão:
150526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141219
[St] Status:MEDLINE
[do] DOI:10.1021/la504130f


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[PMID]:25222557
[Au] Autor:Weidner S; Chrzanowski S; Karamac M; Król A; Badowiec A; Mostek A; Amarowicz R
[Ad] Endereço:Department of Biochemistry, University of Warmia and Mazury, Oczapowskiego Street 1A, 10-957 Olsztyn, Poland. weidner@uwm.edu.pl.
[Ti] Título:Analysis of phenolic compounds and antioxidant abilities of extracts from germinating Vitis californica seeds submitted to cold stress conditions and recovery after the stress.
[So] Source:Int J Mol Sci;15(9):16211-25, 2014 Sep 12.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The material for this study consisted of stratified seeds of Vitis californica submitted to germination under optimum conditions (+25 °C) or under chill stress (+10 °C), also followed by recovery. It has been determined that the germinating seeds contain considerable amounts of tannins, catechins as well as phenolic acids such as gallic, p-coumaric, caffeic and ferulic acids. Gallic acid appeared in the highest amount in the germinating seeds (from 42.40-204.00 µg/g of fresh weight (FW)), followed by caffeic acid (from 6.62-20.13 µg/g FW), p-coumaric acid (from 2.59-5.41 µg/g FW), and ferulic acid (from 0.56-0.92 µg/g FW). The phenolic acids occurred mostly in the ester form. Under chill stress, the germinating seeds were determined to contain an elevated total amount of phenolics, as well as raised levels of condensed tannins, catechins, gallic acid, and gafeic acid. The levels of p-coumoric and ferulic acids were found to have decreased. In extracts isolated from a sample exposed to low temperature, increased antioxidant activity and reduction potential were also demonstrated. Tissue of the germinating seeds which underwent post-stress recovery was found to have less total phenolics.
[Mh] Termos MeSH primário: Antioxidantes/química
Fenóis/análise
Extratos Vegetais/química
Vitis/química
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos/química
Ácidos Carbocíclicos/metabolismo
Catequina/química
Catequina/metabolismo
Cromatografia Líquida de Alta Pressão
Temperatura Baixa
Sementes/química
Sementes/metabolismo
Taninos/química
Taninos/metabolismo
Vitis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids, Carbocyclic); 0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 0 (Tannins); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140916
[St] Status:MEDLINE
[do] DOI:10.3390/ijms150916211


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[PMID]:25222521
[Au] Autor:Kim E; Kim S; Hong JH
[Ad] Endereço:a BK-21 Project Team, College of Pharmacy , Chosun University , Kwangju , Republic of Korea.
[Ti] Título:Synthesis and antiretroviral activity of novel 4'-fluoro-5'-deoxyphosphonic acid carbocyclic nucleoside analogs.
[So] Source:Nucleosides Nucleotides Nucleic Acids;33(10):678-95, 2014.
[Is] ISSN:1532-2335
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Novel 5'-deoxycarbocyclic purine phosphonic acid analogs with the 4'-electropositive moiety, fluorine were designed, and synthesized from glyceraldehyde. The cyclopentenol intermediate, 9, was successfully synthesized by the ring-closing metathesis of divinyl 8. The condensation reaction of cyclopentanol 15 with purine bases under Mitsunobu conditions successfully afforded the desired phosphonate analogs. The synthesized nucleoside phosphonic acid analogs, 19, 22, 26, and 29, were subjected to antiviral screening against human immunodeficiency virus (HIV)-1. Guanine phosphonic acid analog 29 showed significant anti-HIV activity (EC50 = 10.3 µM).
[Mh] Termos MeSH primário: Fármacos Anti-HIV/farmacologia
Guanina/análogos & derivados
HIV-1/efeitos dos fármacos
Organofosfonatos/farmacologia
Nucleotídeos de Purina/síntese química
Nucleotídeos de Purina/farmacologia
[Mh] Termos MeSH secundário: Ácidos Carbocíclicos
Fármacos Anti-HIV/síntese química
Fármacos Anti-HIV/química
Desenho de Drogas
Flúor/química
Gliceraldeído/química
Guanina/síntese química
Guanina/química
Guanina/farmacologia
Organofosfonatos/síntese química
Organofosfonatos/química
Nucleotídeos de Purina/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (9-((4'-fluoro-4'-ethylcyclopentan-1'-yl)guanine)phosphonic acid); 0 (Acids, Carbocyclic); 0 (Anti-HIV Agents); 0 (Organophosphonates); 0 (Purine Nucleotides); 284SYP0193 (Fluorine); 367-47-5 (Glyceraldehyde); 5Z93L87A1R (Guanine)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:140916
[Lr] Data última revisão:
140916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140916
[St] Status:MEDLINE
[do] DOI:10.1080/15257770.2014.920506



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