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[PMID]:29220516
[Au] Autor:Depalo L; Lanzoni A; Masetti A; Pasqualini E; Burgio G
[Ad] Endereço:Dipartimento di Scienze Agrarie-Entomologia, Alma Mater Studiorum-Università di Bologna, Italy.
[Ti] Título:Lethal and Sub-lethal Effects of Four Insecticides on the Aphidophagous Coccinellid Adalia bipunctata (Coleoptera: Coccinellidae).
[So] Source:J Econ Entomol;110(6):2662-2671, 2017 12 05.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Conventional insecticide assays, which measure the effects of insecticide exposure on short-term mortality, overlook important traits, including persistence of toxicity or sub-lethal effects. Therefore, such approaches are especially inadequate for prediction of the overall impact of insecticides on beneficial arthropods. In this study, the side effects of four modern insecticides (chlorantraniliprole, emamectin benzoate, spinosad, and spirotetramat) on Adalia bipunctata (L.) (Coleoptera: Coccinellidae) were evaluated under laboratory conditions by exposition on treated potted plants. In addition to investigation of acute toxicity and persistence of harmful activity in both larvae and adults of A. bipunctata, demographic parameters were evaluated, to provide a comprehensive picture of the nontarget effects of these products. Field doses of the four insecticides caused detrimental effects to A. bipunctata; but in different ways. Overall, spinosad showed the best toxicological profile among the products tested. Emamectin benzoate could be considered a low-risk insecticide, but had high persistence. Chlorantraniliprole exhibited lethal effects on early instar larvae and adults, along with a long-lasting activity, instead spirotetramat showed a low impact on larval and adult mortality and can be considered a short-lived insecticide. However, demographic analysis demonstrated that chlorantraniliprole and spirotetramat caused sub-lethal effects. Our findings highlight that sole assessment of mortality can lead to underestimation of the full impact of pesticides on nontarget insects. Demographic analysis was demonstrated to be a sensitive method for detection of the sub-lethal effects of insecticides on A. bipunctata, and this approach should be considered for evaluation of insecticide selectivity.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Inseticidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Compostos Aza/toxicidade
Coleópteros/crescimento & desenvolvimento
Combinação de Medicamentos
Ivermectina/análogos & derivados
Ivermectina/toxicidade
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Macrolídeos/toxicidade
Compostos de Espiro/toxicidade
ortoaminobenzoatos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Aza Compounds); 0 (Drug Combinations); 0 (Insecticides); 0 (Macrolides); 0 (Spiro Compounds); 0 (ortho-Aminobenzoates); 4G7KR034OX (spirotetramat); 622AK9DH9G (chlorantranilipole); 70288-86-7 (Ivermectin); HVM3G4A01W (emamectin benzoate); XPA88EAP6V (spinosad)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox243


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[PMID]:29298067
[Au] Autor:Thomas M; Kim S; Guo W; Collins FW; Wise ML; Meydani M
[Ad] Endereço:Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University , 711 Washington Street, Boston, Massachusetts 02111, United States.
[Ti] Título:High Levels of Avenanthramides in Oat-Based Diet Further Suppress High Fat Diet-Induced Atherosclerosis in Ldlr Mice.
[So] Source:J Agric Food Chem;66(2):498-504, 2018 Jan 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oats, in addition to cholesterol-lowering properties, contain unique antioxidants called avenanthramides (Avns), which inhibit both inflammatory cytokines and adhesion molecules in endothelial cells in culture. This study evaluated the effects of Avns of oats on atherosclerosis in Ldlr mice, one of the most commonly used atherosclerosis mouse models with their similar cholesterol distributions to humans. The Ldlr mice were fed a low fat, high fat, high fat containing regular oat brans with low levels of Avns (HFLA), or high fat containing regular oat brans with high levels of Avns (HFHA) diet. After 16 weeks of intervention, blood cholesterol and extent of aortic lesions were evaluated. We found that both oat-based diets reduced high fat diet-induced atheroma lesions in the aortic valve (p < 0.01). Furthermore, the effects of oat-based diets are more profound in HFHA mice than mice fed HFLA. Total plasma cholesterol levels were similarly reduced in both oat-supplemented mice. We concluded that oat bran diets reduce atheroma lesions and higher levels of Avns further reduce aortic lesions compared to regular oat bran. These preliminary in vivo data indicate that consumption of oats bran, with high Avns, has demonstrable beneficial effects on prevention of cardiovascular disease.
[Mh] Termos MeSH primário: Aterosclerose/dietoterapia
Avena/metabolismo
Extratos Vegetais/metabolismo
Receptores de LDL/deficiência
ortoaminobenzoatos/metabolismo
[Mh] Termos MeSH secundário: Animais
Aterosclerose/etiologia
Aterosclerose/metabolismo
Avena/química
Colesterol/metabolismo
Dieta Hiperlipídica/efeitos adversos
Fibras na Dieta/metabolismo
Suplementos Nutricionais/análise
Seres Humanos
Masculino
Camundongos
Extratos Vegetais/análise
Receptores de LDL/genética
ortoaminobenzoatos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fiber); 0 (Plant Extracts); 0 (Receptors, LDL); 0 (avenanthramide-2C); 0 (ortho-Aminobenzoates); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04860


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[PMID]:29322271
[Au] Autor:Stenert C; de Mello ÍCMF; Pires MM; Knauth DS; Katayama N; Maltchik L
[Ad] Endereço:Laboratory of Ecology and Conservation of Aquatic Ecosystems, UNISINOS, Unisinos Avenue, 950, São Leopoldo, RS, 93.022-750, Brazil. cstenert@unisinos.br.
[Ti] Título:Responses of macroinvertebrate communities to pesticide application in irrigated rice fields.
[So] Source:Environ Monit Assess;190(2):74, 2018 Jan 10.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The ability to recover to original states after disturbances makes macroinvertebrates useful tools for assessing the impacts of pesticides. Many studies showed that direct exposure to pesticides decreases macroinvertebrate richness and alters their composition. The main objective of this study was to assess recovery patterns in macroinvertebrate communities after pesticide application in irrigated rice fields. We analyzed short-term temporal dynamics of macroinvertebrate communities after application of the herbicides bispyribac-sodium and clomazone and the insecticide chlorantraniliprole, over the rice-growing season in southern Brazil. We selected three conventional rice fields and the recovery of macroinvertebrate communities was also compared with three adjacent natural ponds. The study was developed from November 2011 to February 2012 (rice-growing season). Five macroinvertebrate collections were carried out 3, 7, 14, 38, and 60 days after pesticide application (November 25). Rice fields showed lower richness and abundance than ponds in the period immediately after pesticide application, and recovery rates in the richness of macroinvertebrate communities were more conspicuous as pesticide residuals dissipated from the fields. Macroinvertebrate community structure in rice fields also became more similar to natural ponds as pesticide traces were scarcer. However, macroinvertebrate abundance patterns were not related to pesticide concentrations in the fields. Our results supported the general hypothesis on the negative effects of pesticide application on macroinvertebrate community in irrigated rice fields, although other environmental features (e.g., length of the flooded period) also contributed to explain temporal dynamics in the macroinvertebrate communities from irrigated rice fields.
[Mh] Termos MeSH primário: Irrigação Agrícola
Herbicidas/toxicidade
Inseticidas/toxicidade
Invertebrados/efeitos dos fármacos
Oryza
[Mh] Termos MeSH secundário: Animais
Benzoatos/análise
Benzoatos/toxicidade
Monitoramento Ambiental/métodos
Herbicidas/análise
Inseticidas/análise
Isoxazóis/análise
Isoxazóis/toxicidade
Oxazolidinonas/análise
Oxazolidinonas/toxicidade
Pirimidinas/análise
Pirimidinas/toxicidade
ortoaminobenzoatos/análise
ortoaminobenzoatos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Herbicides); 0 (Insecticides); 0 (Isoxazoles); 0 (Oxazolidinones); 0 (Pyrimidines); 0 (ortho-Aminobenzoates); 570RAC03NF (clomazone); 622AK9DH9G (chlorantranilipole); 9W20BD966G (bispyribac)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6425-1


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[PMID]:29179179
[Au] Autor:Shi R; Xiao ZT; Zheng YJ; Zhang YL; Xu JW; Huang JH; Zhou WL; Li PB; Su WW
[Ad] Endereço:Guangdong Engineering & Technology Research Center for Quality and Efficacy Re-evaluation of Post-market Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
[Ti] Título:Naringenin Regulates CFTR Activation and Expression in Airway Epithelial Cells.
[So] Source:Cell Physiol Biochem;44(3):1146-1160, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Sputum symptoms are commonly seen in the elderly. This study aimed to identify an efficacious expectorant treatment stratagem through evaluating the secretion-promoting activation and cystic fibrosis transmembrane conductance regulator (CFTR) expression of the bioactive herbal monomer naringenin. METHODS: Vectorial Cl- transport was determined by measuring short-circuit current (ISC) in rat airway epithelium. cAMP content was measured by ELISA in primary cultured epithelial cells and Calu-3 cells. CFTR expression in Calu-3 cells was determined by qPCR. RESULTS: Addition of naringenin to the basolateral side of the rat airway led to a concentration-dependent sustained increase in ISC. The current was suppressed when exposed to Cl--free solution or by bumetanide, BaCl2, and DPC but not by DIDS and IBMX. Forskolin-induced ISC increase and CFTRinh-172/MDL-12330A-induced ISC inhibition were not altered by naringenin. Intracellular cAMP content was significantly increased by naringenin. With lipopolysaccharide stimulation, CFTR expression was significantly reduced, and naringenin dose-dependently enhanced CFTR mRNA expression. CONCLUSION: These results demonstrate that naringenin has the ability to stimulate Cl- secretion, which is mediated by CFTR through a signaling pathway by increasing cAMP content. Moreover, naringenin can increase CFTR expression when organism CFTR expression is seriously hampered. Our data suggest a potentially effective treatment strategy for sputum.
[Mh] Termos MeSH primário: Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo
Células Epiteliais/efeitos dos fármacos
Flavanonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Compostos de Bário/farmacologia
Benzoatos/farmacologia
Células Cultivadas
Canais de Cloreto/antagonistas & inibidores
Canais de Cloreto/metabolismo
Cloretos/farmacologia
Colforsina/farmacologia
AMP Cíclico/análise
Regulador de Condutância Transmembrana em Fibrose Cística/antagonistas & inibidores
Regulador de Condutância Transmembrana em Fibrose Cística/genética
Células Epiteliais/citologia
Células Epiteliais/metabolismo
Feminino
Seres Humanos
Iminas/farmacologia
Transporte de Íons/efeitos dos fármacos
Masculino
Microscopia de Fluorescência
Ratos
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Tiazolidinas/farmacologia
Traqueia/citologia
ortoaminobenzoatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone); 0 (Barium Compounds); 0 (Benzoates); 0 (Chloride Channels); 0 (Chlorides); 0 (Flavanones); 0 (Imines); 0 (Thiazolidines); 0 (ortho-Aminobenzoates); 0VK51DA1T2 (barium chloride); 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator); 1F7A44V6OU (Colforsin); 82985-31-7 (RMI 12330A); 952VN06WBB (fenamic acid); E0399OZS9N (Cyclic AMP); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1159/000485419


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[PMID]:29236390
[Au] Autor:Pismenetskaya IU; Butters TD
[Ti] Título:Serum glycomarkers of endoplasmic reticulum and lysosomal-endosomal system stress in human healthy aging and diseases.
[So] Source:Ukr Biochem J;89(1):59-70, 2017 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:To verify the idea that extracellular free oligosaccharides might be able to reflect the functional status of the endoplasmic reticulum (ER) and lysosomal-endosomal system, HPLC-profiles of serum-derived free oligosaccharides (FOS) in human healthy aging, acute myeloproliferative neoplasms, and cardiovascular pathologies were compared with intracellular glycans. After plasma deproteinization and FOS purification the oligosaccharides were labelled with anthranilic acid, separated into the neutral and charged with QAE Sephadex (Q25-120) chromatography and analysed using high-performance liquid chromatography (HPLC). The charged FOS were digested with a sialidase and compared with free oligosaccharides from transferrin for structural decoding. HPLC-profiles of serum-derived FOS revealed mild delay of the dolichol phosphate cycle in ER, moderate intensification of ER-associated degradation (ERAD) and degradation in endosomal-lysosomal system with aging; an inhibition of the dolichol phosphate cycle, intensification of ERAD and increasing of lysosomal exocytosis in acute myeloproliferative neoplasms; intensification of ERAD and glycocojugate degradation with endosomal-lysosomal system in cardiovascular diseases. As serum free oligosaccharides are able to reflect specifically perturbations in ER and endosomal-lysosomal system under wide range of stressors they can serve as extracellular markers of functionality of these organelles.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/sangue
Fosfatos de Dolicol/sangue
Degradação Associada com o Retículo Endoplasmático
Glicoconjugados/sangue
Envelhecimento Saudável/sangue
Transtornos Mieloproliferativos/sangue
Oligossacarídeos/sangue
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Biomarcadores/química
Sequência de Carboidratos
Doenças Cardiovasculares/diagnóstico
Estudos de Casos e Controles
Retículo Endoplasmático/metabolismo
Endossomos/metabolismo
Glicosilação
Seres Humanos
Lisossomos/metabolismo
Transtornos Mieloproliferativos/diagnóstico
Oligossacarídeos/química
Coloração e Rotulagem/métodos
ortoaminobenzoatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Dolichol Phosphates); 0 (Glycoconjugates); 0 (Oligosaccharides); 0 (ortho-Aminobenzoates); 0YS975XI6W (anthranilic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj89.01.059


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[PMID]:29202397
[Au] Autor:Xie R; Li Y; Tang P; Yuan Q
[Ad] Endereço:Medicinal Chemistry Research Division, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029, China.
[Ti] Título:Design, synthesis and biological evaluation of novel 2-aminobenzamides containing dithiocarbamate moiety as histone deacetylase inhibitors and potent antitumor agents.
[So] Source:Eur J Med Chem;143:320-333, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A novel series of 2-aminobenzamides with dithiocarbamate as cap group were designed and synthesized as histone deacetylase (HDAC) inhibitors. Most newly synthesized compounds displayed potent antiproliferative activity against diverse human tumor cell lines. The most potent compounds, M101, M122 and M133 exhibited remarkably enhanced anticancer potency against 6 kinds of cancer cell lines with IC values of as low as 0.54-2.49 µM compared with CS055 (2.28∼ >26 µM) and MS275 (0.47-6.74 µM). HDAC isoform selectivity assay indicated that M101, M122 and M133 are HDAC1 and HDAC2 selective inhibitors. We also rationalize the high potency and selectivity of compound M122 by molecular docking. Further investigation showed that M101, M122 and M133 could inhibit colony formation of human hepatocellular carcinoma cell line SMMC7721. Furthermore, M101, M122 and M133 remarkably induced apoptosis in SMMC7721 cancer cells. M101 and M133 were found to potently induce SMMC7721 cancer cell cycle arrest at G2/M phase. This study demonstrated that introducing dithiocarbamate as the capping group of 2-aminobenzamide is effective for improving both HDAC inhibitory activity and antitumor activity. The most potent compounds, M101, M122 and M133 could be promising candidates for cancer therapy.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Desenho de Drogas
Inibidores de Histona Desacetilases/farmacologia
Histona Desacetilases/metabolismo
Tiocarbamatos/farmacologia
ortoaminobenzoatos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Inibidores de Histona Desacetilases/síntese química
Inibidores de Histona Desacetilases/química
Seres Humanos
Simulação de Acoplamento Molecular
Estrutura Molecular
Relação Estrutura-Atividade
Tiocarbamatos/química
ortoaminobenzoatos/síntese química
ortoaminobenzoatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Histone Deacetylase Inhibitors); 0 (Thiocarbamates); 0 (ortho-Aminobenzoates); EC 3.5.1.98 (Histone Deacetylases); Q1M2WEK6VA (anthranilamide)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:28834007
[Au] Autor:Witzgall F; Ewert W; Blankenfeldt W
[Ad] Endereço:Structure and Function of Proteins, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany.
[Ti] Título:Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis.
[So] Source:Chembiochem;18(20):2045-2055, 2017 Oct 18.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pseudomonas aeruginosa, a prevalent pathogen in nosocomial infections and a major burden in cystic fibrosis, uses three interconnected quorum-sensing systems to coordinate virulence processes. At variance with other Gram-negative bacteria, one of these systems relies on 2-alkyl-4(1H)-quinolones (Pseudomonas quinolone signal, PQS) and might hence be an attractive target for new anti-infective agents. Here we report crystal structures of the N-terminal domain of anthranilate-CoA ligase PqsA, the first enzyme of PQS biosynthesis, in complex with anthraniloyl-AMP and with 6-fluoroanthraniloyl-AMP (6FABA-AMP) at 1.4 and 1.7 Šresolution. We find that PqsA belongs to an unrecognized subfamily of anthranilate-CoA ligases that recognize the amino group of anthranilate through a water-mediated hydrogen bond. The complex with 6FABA-AMP explains why 6FABA, an inhibitor of PQS biosynthesis, is a good substrate of PqsA. Together, our data might pave a way to new pathoblockers in P. aeruginosa infections.
[Mh] Termos MeSH primário: Ligases/química
Ligases/metabolismo
Pseudomonas aeruginosa/citologia
Pseudomonas aeruginosa/metabolismo
Quinolonas/metabolismo
Percepção de Quorum
ortoaminobenzoatos/metabolismo
[Mh] Termos MeSH secundário: Domínio Catalítico
Cristalografia por Raios X
Modelos Moleculares
Pseudomonas aeruginosa/enzimologia
ortoaminobenzoatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Quinolones); 0 (ortho-Aminobenzoates); 0YS975XI6W (anthranilic acid); EC 6.- (Ligases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700374


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[PMID]:28825957
[Au] Autor:Kohavi L; Sprecher E; Zur E; Artzi O
[Ad] Endereço:*Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; †Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; ‡LogiPharm Compounding Pharmacy, Tel-Mond, Israel.
[Ti] Título:The Effect of Tranilast 8% Liposomal Gel Versus Placebo on Post-Cesarean Surgical Scars: A Prospective Double-Blind Split-Scar Study.
[So] Source:Dermatol Surg;43(9):1157-1163, 2017 Sep.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tranilast (N-[3, 4-dimethoxycinnamoyl] anthranilic acid), an antiallergic drug, has been shown to attenuate scar formation possibly through inhibition of transforming growth factor beta 1 activity and consequent suppression of collagen synthesis in fibroblasts. OBJECTIVE: The authors aimed at evaluating the efficacy and safety of tranilast 8% gel in improving the appearance and symptoms of new post-cesarean section surgical wounds. METHODS: In this prospective double-blind split-scar study, the authors treated each half scar of 26 women with either tranilast 8% liposomal gel or tranilast-free liposomal gel (placebo). Treatment was applied twice daily for 3 months. Twenty women completed the trial. Scar halves were evaluated by 2 investigators and by the patients 9 months after the last application using the Patient and Observer Scar Assessment Scale (POSAS). The participants also rated overall satisfaction and recorded side effects of the treatment. RESULTS: The mean POSAS scores at 9 months post-treatment were significantly lower for tranilast-treated half scars compared with placebo-treated half scars (p < .001). The women were significantly more satisfied with the tranilast-treated half-scar appearance (p = .002). Three participants reported itching and erythema on the tranilast-treated side. CONCLUSION: Topical tranilast 8% gel provided significantly better postcaesarian section scar cosmesis and user satisfaction compared with placebo.
[Mh] Termos MeSH primário: Cesárea/efeitos adversos
Cicatriz/tratamento farmacológico
Fármacos Dermatológicos/uso terapêutico
Complicações Pós-Operatórias/tratamento farmacológico
Fator de Crescimento Transformador beta1/antagonistas & inibidores
ortoaminobenzoatos/uso terapêutico
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Fármacos Dermatológicos/administração & dosagem
Fármacos Dermatológicos/efeitos adversos
Método Duplo-Cego
Eritema/induzido quimicamente
Feminino
Géis
Seres Humanos
Meia-Idade
Satisfação do Paciente
Estudos Prospectivos
Prurido/induzido quimicamente
Resultado do Tratamento
Adulto Jovem
ortoaminobenzoatos/administração & dosagem
ortoaminobenzoatos/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dermatologic Agents); 0 (Gels); 0 (Transforming Growth Factor beta1); 0 (ortho-Aminobenzoates); HVF50SMY6E (tranilast)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001140


  9 / 3834 MEDLINE  
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[PMID]:28808157
[Au] Autor:Bhowmick R; Clark S; Bonventre JV; Leong JM; McCormick BA
[Ad] Endereço:School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma, USA.
[Ti] Título:Cytosolic Phospholipase A α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection.
[So] Source:Infect Immun;85(11), 2017 Nov.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary infection by is characterized by a robust alveolar infiltration of neutrophils (polymorphonuclear cells [PMNs]) that can promote systemic spread of the infection if not resolved. We previously showed that 12-lipoxygenase (12-LOX), which is required to generate the PMN chemoattractant hepoxilin A (HXA ) from arachidonic acid (AA), promotes acute pulmonary inflammation and systemic infection after lung challenge with As phospholipase A (PLA ) promotes the release of AA, we investigated the role of PLA in local and systemic disease during infection. The group IVA cytosolic isoform of PLA (cPLA α) was activated upon infection of cultured lung epithelial cells and was critical for AA release from membrane phospholipids. Pharmacological inhibition of this enzyme blocked -induced PMN transepithelial migration Genetic ablation of the cPLA isoform cPLA α dramatically reduced lung inflammation in mice upon high-dose pulmonary challenge with The cPLA α-deficient mice also suffered no bacteremia and survived a pulmonary challenge that was lethal to wild-type mice. Our data suggest that cPLA α plays a crucial role in eliciting pulmonary inflammation during pneumococcal infection and is required for lethal systemic infection following lung challenge.
[Mh] Termos MeSH primário: Células Epiteliais/imunologia
Fosfolipases A2 do Grupo IV/imunologia
Interações Hospedeiro-Patógeno
Pulmão/imunologia
Infecções Pneumocócicas/imunologia
Pneumonia Bacteriana/imunologia
[Mh] Termos MeSH secundário: Animais
Ácido Araquidônico/imunologia
Ácido Araquidônico/metabolismo
Bacteriemia/genética
Bacteriemia/imunologia
Bacteriemia/prevenção & controle
Linhagem Celular Tumoral
Fatores Quimiotáticos/imunologia
Fatores Quimiotáticos/metabolismo
Clorobenzoatos/farmacologia
Cinamatos/farmacologia
Cicloexanonas/farmacologia
Inibidores Enzimáticos/farmacologia
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/enzimologia
Células Epiteliais/microbiologia
Fosfolipases A2 do Grupo IV/antagonistas & inibidores
Fosfolipases A2 do Grupo IV/deficiência
Fosfolipases A2 do Grupo IV/genética
Seres Humanos
Pulmão/efeitos dos fármacos
Pulmão/enzimologia
Pulmão/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Infiltração de Neutrófilos/efeitos dos fármacos
Neutrófilos/efeitos dos fármacos
Neutrófilos/imunologia
Neutrófilos/microbiologia
Infecções Pneumocócicas/genética
Infecções Pneumocócicas/microbiologia
Infecções Pneumocócicas/mortalidade
Pneumonia Bacteriana/genética
Pneumonia Bacteriana/microbiologia
Pneumonia Bacteriana/mortalidade
Streptococcus pneumoniae/efeitos dos fármacos
Streptococcus pneumoniae/genética
Streptococcus pneumoniae/patogenicidade
Análise de Sobrevida
Migração Transendotelial e Transepitelial/efeitos dos fármacos
Migração Transendotelial e Transepitelial/imunologia
ortoaminobenzoatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemotactic Factors); 0 (Chlorobenzoates); 0 (Cinnamates); 0 (Cyclohexanones); 0 (Enzyme Inhibitors); 0 (ortho-Aminobenzoates); 110683-10-8 (4-amylcinnamoylanthranilic acid); 27YG812J1I (Arachidonic Acid); 83654-05-1 (1,6-bis(cyclohexyloximinocarbonyl)hexane); 99754-06-0 (2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid); EC 3.1.1.4 (Group IV Phospholipases A2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


  10 / 3834 MEDLINE  
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[PMID]:28708398
[Au] Autor:Wollenberg RD; Saei W; Westphal KR; Klitgaard CS; Nielsen KL; Lysøe E; Gardiner DM; Wimmer R; Sondergaard TE; Sørensen JL
[Ad] Endereço:Department of Chemistry and Bioscience, Aalborg University , Fredrik Bajers Vej 7H, 9220 Aalborg Ø, Denmark.
[Ti] Título:Chrysogine Biosynthesis Is Mediated by a Two-Module Nonribosomal Peptide Synthetase.
[So] Source:J Nat Prod;80(7):2131-2135, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Production of chrysogine has been reported from several fungal genera including Penicillium, Aspergillus, and Fusarium. Anthranilic acid and pyruvic acid, which are expected precursors of chrysogine, enhance production of this compound. A possible route for the biosynthesis using these substrates is via a nonribosomal peptide synthetase (NRPS). Through comparative analysis of the NRPSs from genome-sequenced producers of chrysogine we identified a candidate NRPS cluster comprising five additional genes named chry2-6. Deletion of the two-module NRPS (NRPS14 = chry1) abolished chrysogine production in Fusarium graminearum, indicating that the gene cluster is responsible for chrysogine biosynthesis. Overexpression of NRPS14 enhanced chrysogine production, suggesting that the NRPS is the bottleneck in the biosynthetic pathway.
[Mh] Termos MeSH primário: Alcaloides/metabolismo
Peptídeo Sintases/metabolismo
Quinazolinonas/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/química
Aspergillus/química
Aspergillus/genética
Vias Biossintéticas
Fusarium/química
Fusarium/genética
Estrutura Molecular
Família Multigênica
Penicillium/química
Penicillium/genética
Ácido Pirúvico/metabolismo
Quinazolinonas/química
ortoaminobenzoatos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Quinazolinones); 0 (ortho-Aminobenzoates); 0YS975XI6W (anthranilic acid); 42599-89-3 (chrysogine); 8558G7RUTR (Pyruvic Acid); EC 6.3.2.- (Peptide Synthases); EC 6.3.2.- (non-ribosomal peptide synthase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00822



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