Base de dados : MEDLINE
Pesquisa : D02.241.223.100.133.500 [Categoria DeCS]
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[PMID]:27790756
[Au] Autor:Dreno B; Tan J; Rivier M; Martel P; Bissonnette R
[Ad] Endereço:CHU Nantes, Nantes, France.
[Ti] Título:Adapalene 0.1%/benzoyl peroxide 2.5% gel reduces the risk of atrophic scar formation in moderate inflammatory acne: a split-face randomized controlled trial.
[So] Source:J Eur Acad Dermatol Venereol;31(4):737-742, 2017 Apr.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The efficacy of current topical acne treatments in mitigating the potential for acne scarring is not known. OBJECTIVE: To evaluate the effect of adapalene 0.1%/benzoyl peroxide 2.5% (A/BPO) gel compared to vehicle in reducing the risk of acne scarring. METHODS: Multicentre, randomized, investigator-blinded, vehicle-controlled, split-face study conducted over 6 months. Subjects were adults with active moderate facial acne vulgaris and at least 10 atrophic acne scars at baseline. Efficacy evaluations included counts of atrophic acne scars and primary acne lesions as well as a Scar Global Assessment (SGA; 5-point scale). RESULTS: After 6 months treatment, scar counts remained stable with A/BPO while increasing by approximately 25% with vehicle (mean scar count 11.58 vs. 13.55, respectively, at Month 6; P = 0.036). The percentage of subjects with a SGA of 'almost clear' (hardly visible scars) increased from 9.7% to 45.2% with A/BPO, whereas it did not change with vehicle (P = 0.0032). Total acne lesion counts decreased by 65% with A/BPO and 36% with vehicle (mean lesion count 8.5 vs. 16.1, respectively, at Month 6; P < 0.001). LIMITATIONS: Relatively small study group (31 subjects). CONCLUSION: Topical long-term treatment with A/BPO is effective in reducing the risk of atrophic scars and improving the global severity of scarring.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Combinação Adapaleno e Peróxido de Benzoil/uso terapêutico
Cicatriz/patologia
Cicatriz/prevenção & controle
Fármacos Dermatológicos/uso terapêutico
Dermatoses Faciais/tratamento farmacológico
[Mh] Termos MeSH secundário: Acne Vulgar/complicações
Combinação Adapaleno e Peróxido de Benzoil/efeitos adversos
Adulto
Atrofia/etiologia
Atrofia/prevenção & controle
Cicatriz/etiologia
Fármacos Dermatológicos/efeitos adversos
Dermatoses Faciais/complicações
Feminino
Géis
Seres Humanos
Masculino
Método Simples-Cego
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adapalene, Benzoyl Peroxide Drug Combination); 0 (Dermatologic Agents); 0 (Gels)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.14026


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[PMID]:26885793
[Au] Autor:Friedman A; Waite K; Brandt S; Meckfessel MH
[Ti] Título:Accelerated Onset of Action and Increased Tolerability in Treating Acne With a Fixed-Dose Combination Gel.
[So] Source:J Drugs Dermatol;15(2):231-6, 2016 Feb.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nonadherence to topical acne therapies is a major contributing factor to poor treatment outcomes. Multiple contributing factors have been identified, including a lack of perceived efficacy and fear of side effects. A fixed-dose combination gel of adapalene/benzoyl peroxide gel, 0.1%/2.5% (A-BPO) is an efficacious and safe treatment for a range of acne severities in patients as young as 9 years old. A meta-analysis of 14 clinical studies involving A-BPO was conducted to assess the 4 week efficacy and overall tolerability of this treatment. Over 2,300 subjects were included in the analysis. Mean total, inflammatory, and non-inflammatory lesion counts decreased at 4 weeks by 40.8%, 46.2%, and 37.5%, respectively. Worst post-baseline tolerability scores for stinging/burning, dryness, scaling, and erythema were none or mild for a majority of subjects. The result of this meta-analysis add to the body of literature supporting the use of A-BPO in a variety of acne patients and shows that A-BPO provides meaningful clinical results within 4 weeks and will be well-tolerated for a majority of patients. With a demonstrable quick onset of action and high tolerability, A-BPO may improve adherence, and ultimately treatment outcomes, by addressing factors that contribute to nonadherence.
[Mh] Termos MeSH primário: Acne Vulgar/diagnóstico
Acne Vulgar/tratamento farmacológico
Combinação Adapaleno e Peróxido de Benzoil/administração & dosagem
Fármacos Dermatológicos/administração & dosagem
[Mh] Termos MeSH secundário: Combinação Adapaleno e Peróxido de Benzoil/efeitos adversos
Adolescente
Adulto
Criança
Ensaios Clínicos como Assunto/métodos
Fármacos Dermatológicos/efeitos adversos
Combinação de Medicamentos
Feminino
Géis
Seres Humanos
Masculino
Meia-Idade
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adapalene, Benzoyl Peroxide Drug Combination); 0 (Dermatologic Agents); 0 (Drug Combinations); 0 (Gels)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE


  3 / 4 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:27168522
[Au] Autor:Sittart JA; Costa Ad; Mulinari-Brenner F; Follador I; Azulay-Abulafia L; Castro LC
[Ad] Endereço:Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.
[Ti] Título:Multicenter study for efficacy and safety evaluation of a fixeddose combination gel with adapalen 0.1% and benzoyl peroxide 2.5% (Epiduo® for the treatment of acne vulgaris in Brazilian population.
[So] Source:An Bras Dermatol;90(6 Suppl 1):1-16, 2015 Dec.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The current options for the treatment of acne vulgaris present many mechanisms of action. For several times, dermatologists try topical agents combinations, looking for better results. OBJECTIVES: To evaluate the efficacy, tolerability and safety of a topical, fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel for the treatment of acne vulgaris in the Brazilian population. METHODS: This is a multicenter, open-label and interventionist study. Patients applied 1.0 g of the fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel on the face, once daily at bedtime, during 12 weeks. Lesions were counted in all of the appointments, and the degree of acne severity, overall improvement, tolerability and safety were evaluated in each visit. RESULTS: From 79 recruited patients, 73 concluded the study. There was significant, fast and progressive reduction of non-inflammatory, inflammatory and total number of lesions. At the end of the study, 75.3% of patients had a reduction of >50% in non-inflammatory lesions, 69.9% in inflammatory lesions and 78.1% in total number of lesions. Of the 73 patients, 71.2% had good to excellent response and 87.6% had satisfactory to good response. In the first week of treatment, erythema, burning, scaling and dryness of the skin were frequent complaints, but, from second week on, these signals and symptoms have reduced. CONCLUSION: The fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel is effective, safe, well tolerated and apparently improves patient compliance with the treatment.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Combinação Adapaleno e Peróxido de Benzoil/administração & dosagem
Fármacos Dermatológicos/administração & dosagem
[Mh] Termos MeSH secundário: Acne Vulgar/patologia
Adolescente
Adulto
Anti-Inflamatórios não Esteroides/administração & dosagem
Brasil
Criança
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Masculino
Satisfação do Paciente
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Adapalene, Benzoyl Peroxide Drug Combination); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Dermatologic Agents)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE


  4 / 4 MEDLINE  
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[PMID]:26096777
[Au] Autor:Kwon HH; Park SY; Yoon JY; Min S; Suh DH
[Ad] Endereço:Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:Do tutorials on application method enhance adapalene-benzoyl peroxide combination gel tolerability in the treatment of acne?
[So] Source:J Dermatol;42(11):1058-65, 2015 Nov.
[Is] ISSN:1346-8138
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fixed-dose combination adapalene 0.1% and benzoyl peroxide 2.5% gel (A-BPO) has rarely been studied for Asian acne patients, while they have complained of local irritations more often when applying individual components. In this study, we compared A-BPO gel with benzoyl peroxide (BPO) in terms of efficacy and tolerability in Korean patients first, and assessed the clinical benefit of a dermatological tutorial on application technique in reducing irritations for A-BPO. This study was conducted as a single-blind controlled split-face trial for a 12-week period. Each half facial side of 85 patients was randomly assigned to either A-BPO or BPO. Success rate, lesion counts and safety profiles were evaluated (analysis I). During initial assignment, all patients were further randomized to either dermatological tutorial (DT) or non-tutorial (NT) subgroups depending on the presence of dermatologists' tutorials for application methods to their A-BPO sides. Clinical data of the A-BPO side was compared between two subgroups (analysis II). As a result, A-BPO gel outperformed BPO, demonstrating better efficacy in success rates and lesion counts as early as 1 week. However, A-BPO proved significantly less tolerable compared with both BPO and previous A-BPO data from Caucasians. Bioengineering measurements further confirmed clinical data (analysis I). The DT subgroup achieved much better tolerability with comparable therapeutic efficacies compared with the NT subgroup (analysis II). In conclusion, A-BPO demonstrated higher efficacies in acne compared with BPO in Korean patients, while skin irritation levels were notable concurrently. Dermatologists' education for application methods would significantly decrease these side-effects, maintaining superior efficacy levels.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Combinação Adapaleno e Peróxido de Benzoil/administração & dosagem
Fármacos Dermatológicos/administração & dosagem
[Mh] Termos MeSH secundário: Combinação Adapaleno e Peróxido de Benzoil/efeitos adversos
Adulto
Grupo com Ancestrais do Continente Asiático
Fármacos Dermatológicos/efeitos adversos
Feminino
Géis
Seres Humanos
Masculino
Educação de Pacientes como Assunto
República da Coreia
Método Simples-Cego
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adapalene, Benzoyl Peroxide Drug Combination); 0 (Dermatologic Agents); 0 (Gels)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE
[do] DOI:10.1111/1346-8138.12979



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