Base de dados : MEDLINE
Pesquisa : D02.241.223.100.200 [Categoria DeCS]
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[PMID]:28808157
[Au] Autor:Bhowmick R; Clark S; Bonventre JV; Leong JM; McCormick BA
[Ad] Endereço:School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma, USA.
[Ti] Título:Cytosolic Phospholipase A α Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection.
[So] Source:Infect Immun;85(11), 2017 Nov.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary infection by is characterized by a robust alveolar infiltration of neutrophils (polymorphonuclear cells [PMNs]) that can promote systemic spread of the infection if not resolved. We previously showed that 12-lipoxygenase (12-LOX), which is required to generate the PMN chemoattractant hepoxilin A (HXA ) from arachidonic acid (AA), promotes acute pulmonary inflammation and systemic infection after lung challenge with As phospholipase A (PLA ) promotes the release of AA, we investigated the role of PLA in local and systemic disease during infection. The group IVA cytosolic isoform of PLA (cPLA α) was activated upon infection of cultured lung epithelial cells and was critical for AA release from membrane phospholipids. Pharmacological inhibition of this enzyme blocked -induced PMN transepithelial migration Genetic ablation of the cPLA isoform cPLA α dramatically reduced lung inflammation in mice upon high-dose pulmonary challenge with The cPLA α-deficient mice also suffered no bacteremia and survived a pulmonary challenge that was lethal to wild-type mice. Our data suggest that cPLA α plays a crucial role in eliciting pulmonary inflammation during pneumococcal infection and is required for lethal systemic infection following lung challenge.
[Mh] Termos MeSH primário: Células Epiteliais/imunologia
Fosfolipases A2 do Grupo IV/imunologia
Interações Hospedeiro-Patógeno
Pulmão/imunologia
Infecções Pneumocócicas/imunologia
Pneumonia Bacteriana/imunologia
[Mh] Termos MeSH secundário: Animais
Ácido Araquidônico/imunologia
Ácido Araquidônico/metabolismo
Bacteriemia/genética
Bacteriemia/imunologia
Bacteriemia/prevenção & controle
Linhagem Celular Tumoral
Fatores Quimiotáticos/imunologia
Fatores Quimiotáticos/metabolismo
Clorobenzoatos/farmacologia
Cinamatos/farmacologia
Cicloexanonas/farmacologia
Inibidores Enzimáticos/farmacologia
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/enzimologia
Células Epiteliais/microbiologia
Fosfolipases A2 do Grupo IV/antagonistas & inibidores
Fosfolipases A2 do Grupo IV/deficiência
Fosfolipases A2 do Grupo IV/genética
Seres Humanos
Pulmão/efeitos dos fármacos
Pulmão/enzimologia
Pulmão/microbiologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Infiltração de Neutrófilos/efeitos dos fármacos
Neutrófilos/efeitos dos fármacos
Neutrófilos/imunologia
Neutrófilos/microbiologia
Infecções Pneumocócicas/genética
Infecções Pneumocócicas/microbiologia
Infecções Pneumocócicas/mortalidade
Pneumonia Bacteriana/genética
Pneumonia Bacteriana/microbiologia
Pneumonia Bacteriana/mortalidade
Streptococcus pneumoniae/efeitos dos fármacos
Streptococcus pneumoniae/genética
Streptococcus pneumoniae/patogenicidade
Análise de Sobrevida
Migração Transendotelial e Transepitelial/efeitos dos fármacos
Migração Transendotelial e Transepitelial/imunologia
ortoaminobenzoatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemotactic Factors); 0 (Chlorobenzoates); 0 (Cinnamates); 0 (Cyclohexanones); 0 (Enzyme Inhibitors); 0 (ortho-Aminobenzoates); 110683-10-8 (4-amylcinnamoylanthranilic acid); 27YG812J1I (Arachidonic Acid); 83654-05-1 (1,6-bis(cyclohexyloximinocarbonyl)hexane); 99754-06-0 (2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid); EC 3.1.1.4 (Group IV Phospholipases A2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


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[PMID]:28674327
[Au] Autor:Trabelsi I; Essid K; Frikha MH
[Ad] Endereço:Laboratory of Physical and Organic Chemistry: Department of Chemistry, Faculty of Sciences in Sfax.
[Ti] Título:Esterification of Mixed Carboxylic-fatty Anhydrides Using Amberlyst-15 as Heterogeneous Catalyst.
[So] Source:J Oleo Sci;66(7):667-676, 2017.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The article deals with the use of mixed anhydrides for the synthesis of fatty esters. Both aliphatic and aromatic acids are involved, indicating different behaviors according to the chain length of the aliphatic acid. We describe a novel and efficient method for the synthesis of fatty esters by the esterification reaction of primary, secondary and tertiary alcohols with mixed carboxylic-palmitic anhydrides using resin Amberlyst-15 as heterogeneous acid catalyst. Influence of various reaction parameters such as molar ratio (anhydride/alcohol), catalyst amount, type of alcohol and type of mixed anhydride were studied to optimize the conditions for maximum yield. Among tested anhydrides we quote mainly the 4-chlorobenzoic palmitic anhydride because it was both reactive and selective for the preparation of palmitic acid ester. This anhydride gave a good yield of palmitic ester.
[Mh] Termos MeSH primário: Anidridos/química
Ésteres/síntese química
Ácidos Graxos/química
Estirenos/química
[Mh] Termos MeSH secundário: Ácidos Carboxílicos/química
Catálise
Clorobenzoatos/química
Esterificação
Ácido Palmítico/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anhydrides); 0 (Carboxylic Acids); 0 (Chlorobenzoates); 0 (Esters); 0 (Fatty Acids); 0 (Styrenes); 0 (amberlyst-15); 2V16EO95H1 (Palmitic Acid); IC7888DF4L (4-chlorobenzoic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17008


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[PMID]:28655115
[Au] Autor:Ahn Y; Lee D; Kwon M; Choi IH; Nam SN; Kang JW
[Ad] Endereço:Department of Environmental Engineering, Yonsei University, Wonju, Kangwon-do, 26493, South Korea.
[Ti] Título:Characteristics and fate of natural organic matter during UV oxidation processes.
[So] Source:Chemosphere;184:960-968, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Advanced oxidation processes (AOPs) are widely used in water treatments. During oxidation processes, natural organic matter (NOM) is modified and broken down into smaller compounds that affect the characteristics of the oxidized NOM by AOPs. In this study, NOM was characterized and monitored in the UV/hydrogen peroxide (H O ) and UV/persulfate (PS) processes using a liquid chromatography-organic carbon detector (LC-OCD) technique, and a combination of excitation-emission matrices (EEM) and parallel factor analysis (PARAFAC). The percentages of mineralization of NOM in the UV/H O and UV/PS processes were 20.5 and 83.3%, respectively, with a 10 mM oxidant dose and a contact time of 174 s (UV dose: approximately 30,000 mJ). Low-pressure, Hg UV lamp (254 nm) was applied in this experiment. The steady-state concentration of SO was 38-fold higher than that of OH at an oxidant dose of 10 mM. With para-chlorobenzoic acid (pCBA) as a radical probe compound, we experimentally determined the rate constants of Suwannee River NOM (SRNOM) with OH (k = 3.3 × 10 M s ) and SO (k = 4.55 × 10 M s ). The hydroxyl radical and sulfate radical showed different mineralization pathways of NOM, which have been verified by the use of LC-OCD and EEM/PARAFAC. Consequently, higher steady-state concentrations of SO , and different reaction preferences of OH and SO with the NOM constituent had an effect on the mineralization efficiency.
[Mh] Termos MeSH primário: Substâncias Húmicas/análise
Modelos Químicos
Oxirredução
Raios Ultravioleta
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Clorobenzoatos
Peróxido de Hidrogênio
Radical Hidroxila
Cinética
Compostos Orgânicos
Rios
Sulfatos
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzoates); 0 (Humic Substances); 0 (Organic Chemicals); 0 (Sulfates); 0 (Water Pollutants, Chemical); 0 (sulfate radical); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide); IC7888DF4L (4-chlorobenzoic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28565907
[Au] Autor:Güssregen S; Matter H; Hessler G; Lionta E; Heil J; Kast SM
[Ad] Endereço:R&D, IDD, Structural Design and Informatics, Sanofi-Aventis Deutschland GmbH , Industriepark Höchst, Building G877, 65926 Frankfurt am Main, Germany.
[Ti] Título:Thermodynamic Characterization of Hydration Sites from Integral Equation-Derived Free Energy Densities: Application to Protein Binding Sites and Ligand Series.
[So] Source:J Chem Inf Model;57(7):1652-1666, 2017 Jul 24.
[Is] ISSN:1549-960X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Water molecules play an essential role for mediating interactions between ligands and protein binding sites. Displacement of specific water molecules can favorably modulate the free energy of binding of protein-ligand complexes. Here, the nature of water interactions in protein binding sites is investigated by 3D RISM (three-dimensional reference interaction site model) integral equation theory to understand and exploit local thermodynamic features of water molecules by ranking their possible displacement in structure-based design. Unlike molecular dynamics-based approaches, 3D RISM theory allows for fast and noise-free calculations using the same detailed level of solute-solvent interaction description. Here we correlate molecular water entities instead of mere site density maxima with local contributions to the solvation free energy using novel algorithms. Distinct water molecules and hydration sites are investigated in multiple protein-ligand X-ray structures, namely streptavidin, factor Xa, and factor VIIa, based on 3D RISM-derived free energy density fields. Our approach allows the semiquantitative assessment of whether a given structural water molecule can potentially be targeted for replacement in structure-based design. Finally, PLS-based regression models from free energy density fields used within a 3D-QSAR approach (CARMa - comparative analysis of 3D RISM Maps) are shown to be able to extract relevant information for the interpretation of structure-activity relationship (SAR) trends, as demonstrated for a series of serine protease inhibitors.
[Mh] Termos MeSH primário: Simulação de Dinâmica Molecular
Proteínas/química
Proteínas/metabolismo
[Mh] Termos MeSH secundário: Sítios de Ligação
Proteínas Sanguíneas/química
Proteínas Sanguíneas/farmacologia
Clorobenzoatos/química
Clorobenzoatos/farmacologia
Fator VIIa/química
Fator VIIa/metabolismo
Fator Xa/química
Fator Xa/metabolismo
Inibidores do Fator Xa/química
Inibidores do Fator Xa/farmacologia
Ligantes
Ligação Proteica
Conformação Proteica
Proteínas/antagonistas & inibidores
Relação Quantitativa Estrutura-Atividade
Estreptavidina/química
Estreptavidina/metabolismo
Termodinâmica
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Chlorobenzoates); 0 (Factor Xa Inhibitors); 0 (Ligands); 0 (Proteins); 0 (factor XIIa inhibitor); 059QF0KO0R (Water); 9013-20-1 (Streptavidin); EC 3.4.21.21 (Factor VIIa); EC 3.4.21.6 (Factor Xa); IC7888DF4L (4-chlorobenzoic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jcim.6b00765


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[PMID]:28002779
[Au] Autor:Wang S; Wang J; Sun Y
[Ad] Endereço:Collaborative Innovation Center for Advanced Nuclear Energy Technology, INET, Tsinghua University, Beijing 100084, PR China.
[Ti] Título:Degradation of chlorinated paraben by integrated irradiation and biological treatment process.
[So] Source:J Environ Manage;189:29-35, 2017 Mar 15.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chlorinated paraben, namely, methyl 3, 5-dichloro-4-hydroxybenzoate (MDHB) is the by-product of chlorination disinfection of paraben and frequently detected in the aquatic environments, which exhibited higher persistence and toxicity than paraben itself. In this paper, the combined irradiation and biological treatment process was employed to investigate the removal of MDHB from aqueous solution. The results showed that the removal efficiency of MDHB and total organic carbon (TOC) by irradiation process increased with radiation dose no matter what the initial concentration of MDHB was. The maximum removal efficiency of MDHB was 100%, 91.1%, 93%, respectively, for the initial concentration of MDHB of 1 mg/L, 5 mg/L and 10 mg/L with the radiation dose of 800 Gy. However, the maximum removal efficiency of TOC among all the experimental groups was only 15.3% obtained with the initial concentration of 1 mg/L at dose of 800 Gy. The subsequent biological treatment enhanced the mineralization of MDHB. The suitable radiation dose for the subsequent biological treatment was determined to be 600 Gy. In this case the removal efficiency of TOC increased to about 70%. Compared to the single biological treatment, the integrated irradiation and biological treatment significantly increase the degradation and mineralization of MDHB. Moreover, the dechlorination efficiency reached 77.4% during the integrated irradiation and biological treatment process. In addition, eight intermediates were identified during the combined process and the possible degradation pathway was proposed.
[Mh] Termos MeSH primário: Clorobenzoatos/química
Parabenos/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Carbono/química
Carbono/isolamento & purificação
Clorobenzoatos/metabolismo
Raios gama
Halogenação
Parabenos/metabolismo
Poluentes Químicos da Água/isolamento & purificação
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzoates); 0 (Parabens); 0 (Water Pollutants, Chemical); 0 (methyl 3,5-dichloro-4-hydroxybenzoate); 7440-44-0 (Carbon)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE


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[PMID]:27858250
[Au] Autor:Xu CF; Zhang L; Huang JW; Chen K; Li SP; Jiang JD
[Ad] Endereço:Department of Microbiology, Key Lab of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
[Ti] Título:Aquamicrobium soli sp. nov., a bacterium isolated from a chlorobenzoate-contaminated soil.
[So] Source:Antonie Van Leeuwenhoek;110(3):305-312, 2017 Mar.
[Is] ISSN:1572-9699
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An aerobic, Gram-stain negative, short rod-shaped, asporogenous, non-motile bacterium designated strain NK8 was isolated from a chlorobenzoate contaminated soil in China. Strain NK8 was observed to grow optimally at pH 7.0, 30 °C and in the absence of NaCl in LB medium. The G + C content of the total DNA of strain NK8 was found to be 65.5 mol%. The 16S rRNA gene sequence of strain NK8 showed high similarity to that of Aquamicrobium aerolatum Sa14 (97.3%), followed by Aquamicrobium lusatiense S1 (96.7%) and Mesorhizobium sangali SCAU7 (96.6%). The DNA-DNA relatedness between strain NK8 and A. aerolatum Sa14 was 35.5 ± 0.9%. The major fatty acids of strain NK8 were determined to be C cyclo ω8c (45.6%), C ω7c (33.4%) and C (8.4%). The respiratory quinone was found to be ubiquinone Q-10. The major polyamine was found to be spermidine. The polar lipid profile include the major compounds phosphatidylcholine and diphosphatidylglycerol, and moderate amounts of phosphatidylethanolamine, phosphatidylmonomethylethanolamine, aminolipid and phospholipid. Based on the differential biochemical and physiological characteristics, the geno-, chemo- and phenotypic characteristics, strain NK8 is proposed to represent a novel species of the genus Aquamicrobium, Aquamicrobium soli sp. nov. The type strain is NK8 (=KCTC 52165 =CCTCC AB2016045 ).
[Mh] Termos MeSH primário: Clorobenzoatos/química
Phyllobacteriaceae/classificação
Phyllobacteriaceae/isolamento & purificação
Microbiologia do Solo
Poluentes do Solo/química
[Mh] Termos MeSH secundário: China
Cloretos/metabolismo
DNA Bacteriano/genética
Poluição Ambiental
Ácidos Graxos/análise
Fosfolipídeos/análise
Phyllobacteriaceae/genética
Phyllobacteriaceae/fisiologia
Filogenia
Quinonas/análise
Solo/química
Especificidade da Espécie
Ubiquinona/análogos & derivados
Ubiquinona/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Chlorobenzoates); 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (Quinones); 0 (Soil); 0 (Soil Pollutants); 1339-63-5 (Ubiquinone); EJ27X76M46 (coenzyme Q10); Z63H374SB6 (chlorite)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1007/s10482-016-0800-8


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[PMID]:27766437
[Au] Autor:Adebusoye SA
[Ad] Endereço:Department of Microbiology, Faculty of Science, University of Lagos, Akoka, Yaba, Lagos, Nigeria. sadebusoye@yahoo.com.
[Ti] Título:Biological degradation of 4-chlorobenzoic acid by a PCB-metabolizing bacterium through a pathway not involving (chloro)catechol.
[So] Source:Biodegradation;28(1):37-51, 2017 Feb.
[Is] ISSN:1572-9729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cupriavidus sp. strain SK-3, previously isolated on polychlorinated biphenyl mixtures, was found to aerobically utilize a wide spectrum of substituted aromatic compounds including 4-fluoro-, 4-chloro- and 4-bromobenzoic acids as a sole carbon and energy source. Other chlorobenzoic acid (CBA) congeners such as 2-, 3-, 2,3-, 2,5-, 3,4- and 3,5-CBA were all rapidly transformed to respective chlorocatechols (CCs). Under aerobic conditions, strain SK-3 grew readily on 4-CBA to a maximum concentration of 5 mM above which growth became impaired and yielded no biomass. Growth lagged significantly at concentrations above 3 mM, however chloride elimination was stoichiometric and generally mirrored growth and substrate consumption in all incubations. Experiments with resting cells, cell-free extracts and analysis of metabolite pools suggest that 4-CBA was metabolized in a reaction exclusively involving an initial hydrolytic dehalogenation yielding 4-hydroxybenzoic acid, which was then hydroxylated to protocatechuic acid (PCA) and subsequently metabolized via the ß-ketoadipate pathway. When strain SK-3 was grown on 4-CBA, there was gratuitous induction of the catechol-1,2-dioxygenase and gentisate-1,2-dioxygenase pathways, even if both were not involved in the metabolism of the acid. While activities of the modified ortho- and meta-cleavage pathways were not detectable in all extracts, activity of PCA-3,4-dioxygenase was over ten-times higher than those of catechol-1,2- and gentisate-1,2-dioxygenases. Therefore, the only reason other congeners were not utilized for growth was the accumulation of CCs, suggesting a narrow spectrum of the activity of enzymes downstream of benzoate-1,2-dioxygenase, which exhibited affinity for a number of substituted analogs, and that the metabolic bottlenecks are either CCs or catabolites of the modified ortho-cleavage metabolic route.
[Mh] Termos MeSH primário: Catecóis/metabolismo
Clorobenzoatos/metabolismo
Cupriavidus/metabolismo
Bifenilos Policlorados/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Dioxigenases/metabolismo
Hidroxibenzoatos/metabolismo
Consumo de Oxigênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Chlorobenzoates); 0 (Hydroxybenzoates); 36R5QJ8L4B (protocatechuic acid); DFC2HB4I0K (Polychlorinated Biphenyls); EC 1.13.11.- (Dioxygenases); IC7888DF4L (4-chlorobenzoic acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE
[do] DOI:10.1007/s10532-016-9776-3


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[PMID]:27879680
[Au] Autor:Shul'pin GB; Loginov DA; Shul'pina LS; Ikonnikov NS; Idrisov VO; Vinogradov MM; Osipov SN; Nelyubina YV; Tyubaeva PM
[Ad] Endereço:Semenov Institute of Chemical Physics, Russian Academy of Sciences, ulitsa Kosygina, dom 4, Moscow 119991, Russia. shulpin@chph.ras.ru.
[Ti] Título:Stereoselective Alkane Oxidation with meta-Chloroperoxybenzoic Acid (MCPBA) Catalyzed by Organometallic Cobalt Complexes.
[So] Source:Molecules;21(11), 2016 Nov 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Cobalt pi-complexes, previously described in the literature and specially synthesized and characterized in this work, were used as catalysts in homogeneous oxidation of organic compounds with peroxides. These complexes contain pi-butadienyl and pi-cyclopentadienyl ligands: [(tetramethylcyclobutadiene)(benzene)cobalt] hexafluorophosphate, [(C4Me4)Co(C6H6)]PF6 ( ); diiodo(carbonyl)(pentamethylcyclopentadienyl)cobalt, Cp*Co(CO)I2 ( ); diiodo(carbonyl)(cyclopentadienyl)cobalt, CpCo(CO)I2 ( ); (tetramethylcyclobutadiene)(dicarbonyl)(iodo)cobalt, (C4Me4)Co(CO)2I ( ); [(tetramethylcyclobutadiene)(acetonitrile)(2,2'-bipyridyl)cobalt] hexafluorophosphate, [(C4Me4)Co(bipy)(MeCN)]PF6 ( ); bis[dicarbonyl(B-cyclohexylborole)]cobalt, [(C4H4BCy)Co(CO)2]2 ( ); [(pentamethylcyclopentadienyl)(iodo)(1,10-phenanthroline)cobalt] hexafluorophosphate, [Cp*Co(phen)I]PF6 ( ); diiodo(cyclopentadienyl)cobalt, [CpCoI2]2 ( ); [(cyclopentadienyl)(iodo)(2,2'-bipyridyl)cobalt] hexafluorophosphate, [CpCo(bipy)I]PF6 ( ); and [(pentamethylcyclopentadienyl)(iodo)(2,2'-bipyridyl)cobalt] hexafluorophosphate, [Cp*Co(bipy)I]PF6 ( ). Complexes and catalyze very efficient and stereoselective oxygenation of tertiary C-H bonds in isomeric dimethylcyclohexanes with MCBA: cyclohexanols are produced in 39 and 53% yields and with the / ratio (of isomers with mutual - or -configuration of two methyl groups) 0.05 and 0.06, respectively. Addition of nitric acid as co-catalyst dramatically enhances both the yield of oxygenates and stereoselectivity parameter. In contrast to compounds and , complexes and turned out to be very poor catalysts (the yields of oxygenates in the reaction with -1,2-dimethylcyclohexane were only 5%-7% and / ratio 0.8 indicated that the oxidation is not stereoselective). The chromatograms of the reaction mixture obtained before and after reduction with PPh3 are very similar, which testifies that alkyl hydroperoxides are not formed in this oxidation. It can be thus concluded that the interaction of the alkanes with MCPBA occurs without the formation of free radicals. The complexes catalyze oxidation of alcohols with -butylhydroperoxide (TBHP). For example, -BuOOH efficiently oxidizes 1-phenylethanol to acetophenone in 98% yield if compound is used as a catalyst.
[Mh] Termos MeSH primário: Alcanos/química
Clorobenzoatos/química
Cobalto/química
Compostos Organometálicos/química
[Mh] Termos MeSH secundário: Catálise
Estrutura Molecular
Oxirredução
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Chlorobenzoates); 0 (Organometallic Compounds); 3G0H8C9362 (Cobalt); G203D4H1RB (3-chloroperbenzoic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


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[PMID]:27705845
[Au] Autor:Park D; Shahbaz HM; Kim SH; Lee M; Lee W; Oh JW; Lee DU; Park J
[Ad] Endereço:Department of Biotechnology, Yonsei University, Seoul 03722, South Korea.
[Ti] Título:Inactivation efficiency and mechanism of UV-TiO photocatalysis against murine norovirus using a solidified agar matrix.
[So] Source:Int J Food Microbiol;238:256-264, 2016 Dec 05.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Human norovirus (HuNoV) is the primary cause of viral gastroenteritis worldwide. Fresh blueberries are among high risk foods associated with norovirus related outbreaks. Therefore, it is important to assess intervention strategies to reduce the risk of foodborne illness. The disinfection efficiency of decontamination methods is difficult to evaluate for fruits and vegetables due to an inconsistent degree of contamination and irregular surface characteristics. The inactivation efficiency and mechanism of murine norovirus 1 (MNV-1, a surrogate for HuNoV) was studied on an experimentally prepared solidified agar matrix (SAM) to simulate blueberries using different wavelengths (A, B, C) of UV light both with and without TiO photocatalysis (TP). MNV-1 was inoculated on exterior and interior of SAM and inactivation efficiencies of different treatments were investigated using a number of assays. Initial inoculum levels of MNV-1 on the SAM surface and interior were 5.2logPFU/mL. UVC with TiO (UVC-TP) achieved the highest level of viral reduction for both externally inoculated and internalized MNV-1. Externally inoculated MNV-1 was reduced to non-detectable levels after UVC-TP treatment for 5min while there was still a 0.9 log viral titer after UVC alone. For internalized MNV-1, 3.2 log and 2.7 log reductions were obtained with UVC-TP and UVC alone treatments for 10min, respectively. The Weibull model was applied to describe the inactivation behavior of MNV-1, and the model showed a good fit to the data. An excellent correlation between the steady-state concentration of OH radicals ([OH] ) and viral inactivation was quantified using a para-chlorobenzoic acid (pCBA) probe compound, suggesting that OH radicals produced in the UV-TP reaction were the major species for MNV-1 inactivation. Transmission electron microscopy images showed that the structure of viral particles was completely disrupted with UVC-TP and UVC alone. SDS-PAGE analysis showed that the major capsid protein VP1 was degraded after UVC-TP and UVC alone. Real-time RT-qPCR analysis showed that UVC-TP and UVC alone caused a reduction in the level of viral genomic RNA. Propidium monoazide (PMA) pretreatment RT-qPCR analysis showed that UVC-TP caused damage to the viral capsid protein in addition to viral genomic RNA. UVC both with and without TiO was more effective for MNV-1 inactivation than UVB and UVA. Thus, UVC-TP disinfection aimed to reduce levels of food-borne viruses can inactivate viruses present on the surface and internalized in the interior of blueberries.
[Mh] Termos MeSH primário: Mirtilos Azuis (Planta)/virologia
Desinfecção/métodos
Doenças Transmitidas por Alimentos/prevenção & controle
Frutas/virologia
Norovirus/efeitos da radiação
Raios Ultravioleta
Inativação de Vírus/efeitos dos fármacos
Inativação de Vírus/efeitos da radiação
[Mh] Termos MeSH secundário: Ágar
Animais
Azidas
Proteínas do Capsídeo/metabolismo
Clorobenzoatos/química
Eletroforese em Gel de Poliacrilamida
Doenças Transmitidas por Alimentos/virologia
Gastroenterite/prevenção & controle
Gastroenterite/virologia
Seres Humanos
Camundongos
Microscopia Eletrônica de Transmissão
Norovirus/fisiologia
Propídio/análogos & derivados
Reação em Cadeia da Polimerase em Tempo Real/métodos
Titânio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azides); 0 (Capsid Proteins); 0 (Chlorobenzoates); 0 (propidium monoazide); 15FIX9V2JP (titanium dioxide); 36015-30-2 (Propidium); 9002-18-0 (Agar); D1JT611TNE (Titanium); IC7888DF4L (4-chlorobenzoic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


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[PMID]:27649311
[Au] Autor:Mizukami-Murata S; Sakakibara F; Fujita K; Fukuda M; Kuramata M; Takagi K
[Ad] Endereço:The Japan Society for the Promotion of Science, Tokyo, Japan; Institute for Agro-Environmental Sciences, NARO, Tsukuba, Ibaraki, Japan.
[Ti] Título:Detoxification of hydroxylated polychlorobiphenyls by Sphingomonas sp. strain N-9 isolated from forest soil.
[So] Source:Chemosphere;165:173-182, 2016 Dec.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To examine the biodegradation of hydroxylated polychlorobiphenyls (OH-PCBs), we isolated Sphingomonas sp. strain N-9 from forest soil using mineral salt medium containing 4-hydroxy-3-chlorobiphenyl (4OH-3CB) at the concentration of 10 mg/L. Following incubation with strain N-9, the concentration of 4OH-3CB decreased in inverse proportion to strain N-9 proliferation, and it was converted to 3-chloro-4-hydroxybenzoic acid (4OH-3CBA) after 1 day. We observed that strain N-9 efficiently degraded lowly chlorinated OH-PCBs (1-4 Cl), while highly chlorinated OH-PCBs (5-6 Cl) were less efficiently transformed. Additionally, strain N-9 degraded PCBs and OH-PCBs with similar efficiencies, and the efficiency of OH-PCB degradation was dependent upon the positional relationships between OH-PCB hydroxyl groups and chlorinated rings. OH-PCB biodegradation may result in highly toxic products, therefore, we evaluated the cytotoxicity of two OH-PCBs [4OH-3CB and 4-hydroxy-3,5-dichlorobiphenyl (4OH-3,5CB)] and their metabolites [4OH-3CBA and 3,5-chloro-4-hydroxybenzoic acid (4OH-3,5CBA)] using PC12 rat pheochromocytoma cells. Our results revealed that both OH-PCBs induced cell membrane damage and caused neuron-like elongations in a dose-dependent manner, while similar results were not observed for their metabolites. These results indicated that strain N-9 can convert OH-PCBs into chloro-hydroxybenzoic acids having lower toxicity.
[Mh] Termos MeSH primário: Compostos de Bifenilo/metabolismo
Clorobenzoatos/metabolismo
Hidroxibenzoatos/metabolismo
Bifenilos Policlorados/metabolismo
Sphingomonas/metabolismo
[Mh] Termos MeSH secundário: Animais
Biodegradação Ambiental
Compostos de Bifenilo/toxicidade
Linhagem Celular Tumoral
Clorobenzoatos/toxicidade
Florestas
Hidroxibenzoatos/toxicidade
Hidroxilação
Inativação Metabólica
Células PC12
Bifenilos Policlorados/toxicidade
Ratos
Solo
Microbiologia do Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Chlorobenzoates); 0 (Hydroxybenzoates); 0 (Soil); 3964-58-7 (3-chloro-4-hydroxybenzoate); DFC2HB4I0K (Polychlorinated Biphenyls); IXL47709VM (3,5-dichlorobiphenyl); QA22Z3NGLU (4-chlorobiphenyl); WLQ4633SJY (3-chlorobiphenyl)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE



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