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[PMID]:29441969
[Au] Autor:Lin S; Wu J; Guo W; Zhu Y
[Ti] Título:Effects of leonurine on intracerebral haemorrhage by attenuation of perihematomal edema and neuroinflammation the JNK pathway.
[So] Source:Pharmazie;71(11):644-650, 2016 11 02.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Perihematomal edema plays a critical role in secondary brain injury in intracerebral hemorrhage (ICH), which is associated with inflammation, hematoma toxicity and oxidative stress. In this work, we investigated the protective effects of leonurine, an alkaloid of Herbal Leonuri, and possible mechanisms to provide a basis for a new therapeutic approach for ICH treatment. In in vivo studies, we demonstrated for the first time that leonurine treatment substantially decreased perihematomal edema, ameliorated neurobehavioral function deficits, reduced apoptosis and protected injured cerebral tissue after ICH. These benefits appear to be ascribed to leonurine effectively attenuating bloodbrain barrier (BBB) breakdown in vivo, by inhibiting degradation of hemoglobin and alleviating inflammatory mediator release. In this study, BV-2 cells were exposed in vitro to oxyhemoglobin (OxyHb) at a concentration of 10 µM to mimic neuroinflammation after ICH. Consistent with the results of the in vivo study, leonurine significantly inhibited OxyHbinduced inflammatory proteins expression in BV-2 cells, mainly through inhibiting the c-Jun N-terminal kinase (JNK) signaling pathway. This is the first time that leonurine is proved to be capable to protect the injured cerebral tissue after ICH, based on alleviating neuroinflammation and attenuating BBB breakdown to ameliorate perihematomal edema.
[Mh] Termos MeSH primário: Edema Encefálico/tratamento farmacológico
Hemorragia Cerebral/tratamento farmacológico
Encefalite/tratamento farmacológico
Ácido Gálico/análogos & derivados
Hematoma/tratamento farmacológico
Proteínas Proto-Oncogênicas c-jun/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Barreira Hematoencefálica/efeitos dos fármacos
Água Corporal/metabolismo
Edema Encefálico/patologia
Edema Encefálico/psicologia
Hemorragia Cerebral/psicologia
Encefalite/psicologia
Ácido Gálico/farmacologia
Hematoma/patologia
Hematoma/psicologia
Mediadores da Inflamação/metabolismo
Masculino
Metaloproteinase 9 da Matriz/metabolismo
Oxiemoglobinas/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inflammation Mediators); 0 (Oxyhemoglobins); 0 (Proto-Oncogene Proteins c-jun); 09Q5W34QDA (leonurine); 632XD903SP (Gallic Acid); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, rat)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6692


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[PMID]:29442036
[Au] Autor:Pivodová V; Zahler S; Karas D; Valentová K; Ulrichova J
[Ti] Título: study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis.
[So] Source:Pharmazie;71(8):478-483, 2016 08 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:2,3-Dehydrosilybin exhibits substantial anticancer and antiangiogenic effects, which can be potentially improved by semi-synthetic modification such as esterification with gallic acid. The aim of this study was to examine the potential antiangiogenic effect of 2,3-dehydrosilybin and its galloyl esters (3-O-galloyl-2,3-dehydrosilybin; 7-O-galloyl-2,3-dehydrosilybin; 20-O-galloyl-2,3-dehydrosilybin and 23-O-galloyl-2,3-dehydrosilybin) and to determine which molecular mechanism could be responsible for their activity. The effect on cell proliferation, tube formation, signal transduction pathways (PI3K/Akt and ERK) and the cell cycle was studied in human microvascular endothelial cells (HMEC). The results showed that all compounds decreased the growth of HMEC, but the strongest effect was observed for 20-O-galloyl-2,3-dehydrosilybin at 5 µmol/l. In addition, at 5 and 10 µmol/l, this was the only compound that significantly inhibited HMEC tube formation. Based on an assessment of Akt and ERK1/2 expression, we suggest that 20-O-galloyl-2,3-dehydrosilybin influences the angiogenic process through the Akt pathway.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Silimarina/farmacologia
[Mh] Termos MeSH secundário: Inibidores da Angiogênese/síntese química
Ciclo Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Endoteliais/efeitos dos fármacos
Ésteres/síntese química
Ésteres/farmacologia
Ácido Gálico/síntese química
Ácido Gálico/farmacologia
Seres Humanos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Microtúbulos/efeitos dos fármacos
Neovascularização Patológica/tratamento farmacológico
Proteína Oncogênica v-akt/efeitos dos fármacos
Fosfatidilinositol 3-Quinases/efeitos dos fármacos
Silimarina/síntese química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Esters); 0 (Silymarin); 4RKY41TBTF (silybin); 632XD903SP (Gallic Acid); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Oncogene Protein v-akt)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6579


  3 / 3251 MEDLINE  
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Yunes, Rosendo A
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[PMID]:28746057
[Au] Autor:Cordova CAS; Locatelli C; Winter E; Silva AH; Zanetti-Ramos BG; Jasper R; Mascarello A; Yunes RA; Nunes RJ; Creczynski-Pasa TB
[Ad] Endereço:aDepartment of Pharmaceutical Sciences bDepartment of Biochemistry cDepartment of Chemistry, Federal University of Santa Catarina dNanovetores Technology S.A., Florianópolis eUniversity of Western Santa Catarina, Videira, SC fFederal University of Tocantins, Araguaína, TO, Brazil.
[Ti] Título:Solid lipid nanoparticles improve octyl gallate antimetastatic activity and ameliorate its renal and hepatic toxic effects.
[So] Source:Anticancer Drugs;28(9):977-988, 2017 10.
[Is] ISSN:1473-5741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Metastasis is the main cause of cancer-related death and requires the development of effective treatments with reduced toxicity and effective anticancer activity. Gallic acid derivatives have shown significant biological properties including antitumoral activity as shown in a previous study with octyl gallate (G8) in vitro. Thus, the aim of this work was to evaluate the antimetastatic effect of free and solid lipid nanoparticle-loaded G8 in mice in a lung metastasis model. Animals inoculated with melanoma cells presented metastasis in lungs, which was significantly inhibited by treatment with G8 and solid lipid nanoparticle-loaded G8, named G8-NVM. However, G8-treated mice showed an increase in several toxicological parameters, which were almost completely circumvented by G8-NVM treatment. This study supports the need for pharmacological studies on new potential medicinal plants to treat cancer and can provide new perspectives on using nanotechnology to improve biological activities while decreasing the chemotherapy toxicological effects of anticancer drugs.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Ácido Gálico/análogos & derivados
Nefropatias/induzido quimicamente
Nefropatias/prevenção & controle
Lipídeos/administração & dosagem
Nanopartículas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Cercopithecus aethiops
Feminino
Ácido Gálico/administração & dosagem
Ácido Gálico/efeitos adversos
Ácido Gálico/química
Lipídeos/química
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/secundário
Melanoma Experimental/tratamento farmacológico
Melanoma Experimental/metabolismo
Melanoma Experimental/patologia
Camundongos
Nanopartículas/química
Metástase Neoplásica
Espécies Reativas de Oxigênio/metabolismo
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipids); 0 (Reactive Oxygen Species); 079IIA2811 (octyl gallate); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1097/CAD.0000000000000539


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[PMID]:29205955
[Au] Autor:Li B; Weng Q; Liu Z; Shen M; Zhang J; Wu W; Liu H
[Ad] Endereço:College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China.
[Ti] Título:Selection of antioxidants against ovarian oxidative stress in mouse model.
[So] Source:J Biochem Mol Toxicol;31(12), 2017 Dec.
[Is] ISSN:1099-0461
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxidative stress (OS) plays an important role in the process of ovarian granulosa cell apoptosis and follicular atresia. The aim of this study was to select antioxidant against OS in ovary tissue. Firstly, we chose the six antioxidants and analyzed the reactive oxygen species (ROS) level in the ovary tissue. The results showed that proanthocyanidins, gallic acid, curcumin, and carotene decrease the ROS level compared with control group. We further demonstrated that both proanthocyanidins and gallic acid increase the antioxidant enzymes activity. Moreover, change in the ROS level was not observed in proanthocyanidins and gallic acid group of brain, liver, spleen, and kidney tissues. Finally, we found that proanthocyanidins and gallic acid inhibit pro-apoptotic genes expression in granulosa cells. Taken together, proanthocyanidins and gallic acid may be the most acceptable and optimal antioxidants specifically against ovarian OS and also may be involved in the inhibition of granulosa cells apoptosis in mouse ovary.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Ácido Gálico/farmacologia
Ovário/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Proantocianidinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose
Proteínas Reguladoras de Apoptose/genética
Proteínas Reguladoras de Apoptose/metabolismo
Avaliação Pré-Clínica de Medicamentos
Feminino
Expressão Gênica/efeitos dos fármacos
Camundongos Endogâmicos ICR
Ovário/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Apoptosis Regulatory Proteins); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 18206-61-6 (proanthocyanidin); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/jbt.21997


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[PMID]:29331653
[Au] Autor:Garud MS; Kulkarni YA
[Ad] Endereço:Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India.
[Ti] Título:Gallic acid attenuates type I diabetic nephropathy in rats.
[So] Source:Chem Biol Interact;282:69-76, 2018 Feb 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Literature suggests that TGF-ß1 has a central role in the progression of diabetic nephropathy and its down regulation can improve the disease condition. Oxidative stress, generation of advanced glycation end products and activation of renin angiotensin system are the connecting links between hyperglycemia and TGF-ß1 over expression. Gallic acid is a phytochemical having wide range of biological activities. Gallic acid is reported to have antioxidant and advanced glycation inhibitory activity. It has also shown inhibitory effects on angiotensin converting enzyme. Gallic acid qualifies as a drug candidate to be tested in the diabetic nephropathy, one of the important complication of diabetes. Streptozotocin (55 mg/kg body weight, i.p.) induced diabetic nephropathy was used as an experimental model. Gallic acid was evaluated for its possible effect at the dose of 20 and 40 mg/kg body weight. Gallic acid treatment significantly lowered plasma levels of the creatinine and blood urea nitrogen and elevated the levels of the protein and albumin. Gallic acid also improved creatinine clearance. Determination of oxidative stress parameters showed that the oxidative stress in kidney tissues was reduced significantly in gallic acid treated animals. Results of the plasma, urine and oxidative stress parameters were also reflected in the histopathological evaluation showing improvement in kidney pathophysiology. ELISA assay for circulating TGF-ß1 evaluation and immunohistochemical study for determination of kidney expression of TGF-ß1 revealed that gallic acid significantly lowered both the circulating and tissue levels of TGF-ß1. Results support the hypothesis that gallic acid can be effectively used in the treatment of diabetic nephropathy.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/complicações
Nefropatias Diabéticas/tratamento farmacológico
Nefropatias Diabéticas/etiologia
Ácido Gálico/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Nitrogênio da Ureia Sanguínea
Creatinina/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/complicações
Modelos Animais de Doenças
Rim/efeitos dos fármacos
Rim/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Estreptozocina/farmacologia
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Transforming Growth Factor beta1); 5W494URQ81 (Streptozocin); 632XD903SP (Gallic Acid); AYI8EX34EU (Creatinine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


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[PMID]:28942286
[Au] Autor:Can ÖD; Turan N; Demir Özkay Ü; Öztürk Y
[Ad] Endereço:Anadolu University, Faculty of Pharmacy, Department of Pharmacology, 26470 Eskisehir, Turkey. Electronic address: ozgurdt@anadolu.edu.tr.
[Ti] Título:Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems.
[So] Source:Life Sci;190:110-117, 2017 Dec 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: This study was planned to examine the antidepressant potency of gallic acid (30 and 60mg/kg), a phenolic acid widely distributed in nature, together with its possible underlying monoaminergic mechanisms. MAIN METHODS: Antidepressant-like activity was assessed using the tail suspension (TST) and the modified forced swimming tests (MFST). Locomotor activity was evaluated in an activity cage. KEY FINDINGS: Administration of gallic acid at 60mg/kg reduced the immobility duration of mice in both the TST and MFST without any changes in the locomotor activity. The anti-immobility effect observed in the TST was abolished with pre-treatment of p-chlorophenylalanine methyl ester (an inhibitor of serotonin synthesis; 100mg/kg i.p. administered for 4-consecutive days), ketanserin (a 5-HT2A/2C antagonist; 1mg/kg i.p.), ondansetron (a 5-HT3 antagonist; 0.3mg/kg i.p.), α-methyl-para-tyrosine methyl ester (an inhibitor of catecholamine synthesis; 100mg/kg i.p.), phentolamine (non-selective alpha-adrenoceptor antagonist; 5mg/kg i.p.), SCH 23390 (a dopamine D1 antagonist; 0.05mg/kg s.c.), and sulpiride (a dopamine D2/D3 antagonist; 50mg/kg i.p.). However, NAN 190 (a 5-HT1A antagonist; 0.5mg/kg i.p.) and propranolol (a non-selective ß-adrenoceptor antagonist; 5mg/kg i.p.) pre-treatments were ineffective at reversing the antidepressant-like effects of gallic acid. SIGNIFICANCE: The results of the present study indicate that gallic acid seems to have a dual mechanism of action by increasing not only serotonin but also catecholamine levels in synaptic clefts of the central nervous system. Further alpha adrenergic, 5-HT2A/2C and 5-HT3 serotonergic, and D1, D2, and D3 dopaminergic receptors also seem to be involved in this antidepressant-like activity.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Depressão/tratamento farmacológico
Ácido Gálico/farmacologia
Atividade Motora/efeitos dos fármacos
Serotonina/metabolismo
[Mh] Termos MeSH secundário: Animais
Antidepressivos/administração & dosagem
Catecolaminas/metabolismo
Depressão/fisiopatologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Ácido Gálico/administração & dosagem
Elevação dos Membros Posteriores
Imobilização
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Natação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Catecholamines); 333DO1RDJY (Serotonin); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28838645
[Au] Autor:Zhang Y; Cheng Y; Liu Z; Ding L; Qiu T; Chai L; Qiu F; Wang Z; Xiao W; Zhao L; Chen X
[Ad] Endereço:School of Pharmacy, Shenyang Pharmaceutical University, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China.
[Ti] Título:Systematic screening and characterization of multiple constituents in Guizhi Fuling capsule and metabolic profiling of bioactive components in rats using ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1061-1062:474-486, 2017 Sep 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Guizhi Fuling capsule (GFC), a prestigious traditional Chinese medicinal (TCM) prescription, is efficiently used to treat primary dysmenorrhea in the clinical practice. It's significant to explore the metabolic fate of multiple components in vivo which are responsible for the pharmacological effects but not fully investigated. A rapid and high-throughput method using ultra performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS/MS) was established for systematic investigation on GFC, including GFC chemical compositions, and their absorption and metabolism in rat plasma, urine, uterus and brain after oral administration of GFC. A total of 102 nonvolatile GFC phytochemistry components were identified based on the accurately measured mass value, fragmentation pattern and retention behavior. Compared to the previous GFC study, additional 47 different GFC components were detected. Furthermore 21, 9, 4 and 3 prototype compounds were separately observed in plasma, urine, uterus and brain samples with the support of in vitro GFC study. While 29, 33, 10 and 8 metabolites were also identified with the assistance of the MetaboLynx tool in these biological samples. The result indicated that the developed method was suitable for the components identification even in the complex matrix. The chemical and metabolic profiling of GFC provided an abundant substance foundation for the extensive GFC research, especially for the pharmacodynamic mechanisms research.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas
Metabolômica/métodos
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Acetofenonas/análise
Acetofenonas/química
Acetofenonas/metabolismo
Animais
Encéfalo/metabolismo
Química Encefálica
Cápsulas
Medicamentos de Ervas Chinesas/análise
Medicamentos de Ervas Chinesas/metabolismo
Medicamentos de Ervas Chinesas/farmacocinética
Feminino
Ácido Gálico/análise
Ácido Gálico/química
Ácido Gálico/metabolismo
Glicosídeos/análise
Glicosídeos/química
Glicosídeos/metabolismo
Monoterpenos/análise
Monoterpenos/química
Monoterpenos/metabolismo
Ratos
Ratos Sprague-Dawley
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Distribuição Tecidual
Útero/química
Útero/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetophenones); 0 (Capsules); 0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Monoterpenes); 0 (guizhi-fuling); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  8 / 3251 MEDLINE  
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[PMID]:28789935
[Au] Autor:Zhou R; Liu ZQ
[Ad] Endereço:Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, China.
[Ti] Título:Tetramer as efficient structural mode for organizing antioxidative carboxylic acids: The case in inhibiting DNA oxidation.
[So] Source:Arch Biochem Biophys;631:1-10, 2017 Oct 01.
[Is] ISSN:1096-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To overcome the problem on the relationship of antioxidative effect with the branch number in a tetramer, we herein designed a series of antioxidants with pentaerythritol, glycerol, and ethylene glycol as the cores, and gallic, ferulic, caffeic, and p-hydroxybenzoic acids as the antioxidative moieties. In the case of DNA oxidation mediated by 2,2'-azobis(2-amidinopropane hydrochloride, AAPH), it was found that the stoichiometric factor (n) of a carboxylic acid increased rapidly when the acid was esterified with ethylene glycol, glycerol, and pentaerythritol to form a dimer, trimer, and tetramer, respectively. Interestingly, the coefficient in the equation of n∼{branch} ({branch} referred to the number of branches) was higher than one, indicating that the antioxidative effect was enhanced more promptly than the increase of the number of branches. Meanwhile, tetramer exhibited high intercalation effect with DNA strand. Therefore, additionally antioxidative effect was ascribed to the tethering effect resulting from tetrameric structure and strong intercalation with DNA strand generated by tetramer.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Ácidos Carboxílicos/química
Ácidos Carboxílicos/farmacologia
DNA/química
Oxirredução/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amidinas/química
Antioxidantes/síntese química
Ácidos Cafeicos/síntese química
Ácidos Cafeicos/química
Ácidos Cafeicos/farmacologia
Ácidos Carboxílicos/síntese química
Ácidos Cumáricos/síntese química
Ácidos Cumáricos/química
Ácidos Cumáricos/farmacologia
Dimerização
Esterificação
Ácido Gálico/síntese química
Ácido Gálico/química
Ácido Gálico/farmacologia
Hidroxibenzoatos/síntese química
Hidroxibenzoatos/química
Hidroxibenzoatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amidines); 0 (Antioxidants); 0 (Caffeic Acids); 0 (Carboxylic Acids); 0 (Coumaric Acids); 0 (Hydroxybenzoates); 632XD903SP (Gallic Acid); 7381JDR72F (2,2'-azobis(2-amidinopropane)); 9007-49-2 (DNA); AVM951ZWST (ferulic acid); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE


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[PMID]:28778164
[Au] Autor:Shah NA; Khan MR; Nigussie D
[Ad] Endereço:Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan. drnaseeralishah@gmail.com.
[Ti] Título:Phytochemical investigation and nephroprotective potential of Sida cordata in rat.
[So] Source:BMC Complement Altern Med;17(1):388, 2017 Aug 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants are an efficient source of natural antioxidant against free radicals causing kidney damages. Sida cordata ethyl acetate fraction has been reported for strong in vitro antioxidant potency, previously. In the present study, our objective was to evaluate its in vivo antioxidant potency against CCl induced nephrotoxicity and investigates the bioactive phytochemicals by HPLC-DAD analysis. METHODS: Phytochemical analysis was performed by HPLC-DAD methodology. For in vivo study, 42 male Sprague-Dawley rats were treated with alternatively managed doses for 60 days. Group I animals were remained untreated. Group II animals were treated with vehicle (1 mL of olive oil) by intragastric route on alternate days. Group III was treated with 30% CCl (1 mL/kg b.w.) i.p. Group IV was treated with 30% CCl (1 mL/kg b.w.) i.p and silymarin intragastric. Group V and VI rats were treated with 30% CCl and SCEE (150 and 300 mg/kg b.w., respectively) intragastric. Group VII animals were treated with SCEE (300 mg/kg b.w.) intragastrically. Blood parameters, Serum proteins and urine profile were investigated. Activities of tissue enzyme i.e. catalase, peroxidase, superoxide dismutase, glutathione-S-transferase, glutathione reductase, GSH and γ-GT were evaluated. Histopathological observations, total protein contents, lipid peroxidation, DNA damage and relative weight were also analyzed. RESULTS: Gallic acid, catechin and caffeic acid were identified in SCEE fraction by HPLC-DAD. Decrease in the count of red blood cells, neutrophils, eosinophils and concentration of hemoglobin whereas increase in lymphocyte count and estimation of sedimentation rate (ESR) with 1 mL CCl (30% in Olive oil) administration (30 doses in 60 days) was restored dose dependently with co-treatment of SCEE (150 and 300 mg/kg b.w.). Treatment of rats with CCl markedly (P < 0.01) increased the count of urinary red blood cells and leucocytes, concentration of urea, creatinine and urobilinogen and specific gravity whereas creatinine clearance was reduced. Serum level of total protein, albumin, globulin, nitrite, creatinine and blood urea nitrogen (BUN) was significantly increased (P < 0.01) by CCl treatment. The activity of antioxidant enzymes; catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase and content of reduced glutathione was decreased (P < 0.01) significantly. However, increased concentration (P < 0.01) of thiobarbituric acid reactive substances and histopathological injuries were noticed in the renal tissues of rats after the treatment with CCl . Co-administration of SCEE, dose dependently, protected the alterations in the studied parameters of rats at 150 and 300 mg/kg b.w. The present study revealed that SCEE could be used as a possible remedy for renal toxicity abnormalities. CONCLUSION: These results are an evidence of the renal protective role of S.cordat ethyl acetate fraction against CCl induced nephrotoxicity in rats which may be due to its antioxidant compounds.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Ácidos Cafeicos/uso terapêutico
Catequina/uso terapêutico
Ácido Gálico/uso terapêutico
Nefropatias/prevenção & controle
Rim/efeitos dos fármacos
Malvaceae/química
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Antioxidantes/uso terapêutico
Proteínas Sanguíneas/metabolismo
Ácidos Cafeicos/análise
Ácidos Cafeicos/farmacologia
Tetracloreto de Carbono
Catequina/análise
Catequina/farmacologia
Dano ao DNA
Ácido Gálico/análise
Ácido Gálico/farmacologia
Rim/enzimologia
Rim/metabolismo
Rim/patologia
Nefropatias/metabolismo
Nefropatias/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Estresse Oxidativo/efeitos dos fármacos
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/farmacologia
Compostos Fitoquímicos/uso terapêutico
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Ratos Sprague-Dawley
Substâncias Reativas com Ácido Tiobarbitúrico
Urinálise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Proteins); 0 (Caffeic Acids); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Thiobarbituric Acid Reactive Substances); 632XD903SP (Gallic Acid); 8R1V1STN48 (Catechin); CL2T97X0V0 (Carbon Tetrachloride); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1896-8


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[PMID]:28766866
[Au] Autor:Athukuri BL; Neerati P
[Ad] Endereço:DMPK and Clinical Pharmacology Division, Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, 506 009, TS, India.
[Ti] Título:Enhanced Oral Bioavailability of Diltiazem by the Influence of Gallic Acid and Ellagic Acid in Male Wistar Rats: Involvement of CYP3A and P-gp Inhibition.
[So] Source:Phytother Res;31(9):1441-1448, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The oral bioavailability of diltiazem is very low due to rapid first pass metabolism in liver and intestine. The purpose of the study was to investigate the effect of gallic acid and ellagic acid on intestinal transport and oral bioavailability of diltiazem in rats. The intestinal transport and permeability of diltiazem was evaluated by in vitro non-everted sac method and in situ single pass intestinal perfusion study. The oral pharmacokinetics was evaluated by conducting oral bioavailability study. The intestinal transport and apparent permeability of diltiazem were significantly enhanced in duodenum, jejunum, and ileum of gallic and ellagic acid-treated groups. The effective permeability of diltiazem was significantly enhanced in ileum part of gallic and ellagic acid-treated groups. When compared with control group, the presence of these two phytochemicals significantly enhanced the area under plasma concentration-time curve and the peak plasma concentration of diltiazem (C ). Gallic acid and ellagic acid significantly increased the bioavailability of diltiazem due to the inhibition of both CYP3A-mediated metabolism and P-glycoprotein-mediated efflux in the intestine and/or liver. Based on these results, the clinical experiments are warranted for the confirmation to reduce the dose of diltiazem when concomitantly administered with these phytochemicals. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Citocromo P-450 CYP3A/metabolismo
Diltiazem/farmacocinética
Ácido Elágico/farmacologia
Ácido Gálico/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Disponibilidade Biológica
Diltiazem/administração & dosagem
Interações Medicamentosas
Absorção Intestinal
Intestinos/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP Binding Cassette Transporter, Sub-Family B); 19YRN3ZS9P (Ellagic Acid); 632XD903SP (Gallic Acid); EC 1.14.14.1 (Cytochrome P-450 CYP3A); EE92BBP03H (Diltiazem)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5873



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