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Pesquisa : D02.241.223.100.300.200.299 [Categoria DeCS]
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  1 / 1947 MEDLINE  
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[PMID]:29336147
[Au] Autor:Xu J; Yuan C; Wang G; Luo J; Ma H; Xu L; Mu Y; Li Y; Seeram NP; Huang X; Li L
[Ad] Endereço:Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University , Shenyang 110819, People's Republic of China.
[Ti] Título:Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways.
[So] Source:J Agric Food Chem;66(3):571-580, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emerging data suggest that urolithins, gut microbiota metabolites of ellagitannins, contribute toward multiple health benefits attributed to ellagitannin-rich foods, including walnuts, red raspberry, strawberry, and pomegranate. However, there is limited data on whether the potential neuroprotective effects of these ellagitannin-rich foods are mediated by urolithins. Herein, we evaluated the potential mechanisms of antineuroinflammatory effects of urolithins (urolithins A, B, and C; 8-methyl-O-urolithin A; and 8,9-dimethyl-O-urolithin C) in BV2 murine microglia in vitro. Nitrite analysis and qRT-PCR suggested that urolithins A and B reduced NO levels and suppressed mRNA levels of pro-inflammatory genes of TNF-α, IL-6, IL-1ß, iNOS, and COX-2 in LPS-treated microglia. Western blot revealed that urolithins A and B decreased phosphorylation levels of Erk1/2, p38 MAPK, and Akt, prevented IκB-α phosphorylation and degradation, and inhibited NF-κB p65 subunit phosphorylation and nuclear translocation in LPS-stimulated microglia. Our results indicated that urolithins A and B attenuated LPS-induced inflammation in BV2 microglia, which may be mediated by inhibiting NF-κB, MAPKs (p38 and Erk1/2), and Akt signaling pathway activation. The antineuroinflammatory activities of urolithins support their role in the potential neuroprotective effects reported for ellagitannin-rich foods warranting further in vivo studies on these ellagitannin gut microbial derived metabolites.
[Mh] Termos MeSH primário: Cumarínicos/farmacologia
Taninos Hidrolisáveis/farmacologia
Lipopolissacarídeos/efeitos adversos
Microglia/efeitos dos fármacos
Quinases de Proteína Quinase Ativadas por Mitógeno/imunologia
Fármacos Neuroprotetores/farmacologia
Proteínas Proto-Oncogênicas c-akt/imunologia
Fator de Necrose Tumoral alfa/imunologia
[Mh] Termos MeSH secundário: Animais
Cumarínicos/química
Taninos Hidrolisáveis/química
Camundongos
Microglia/imunologia
Quinases de Proteína Quinase Ativadas por Mitógeno/genética
Proteínas Proto-Oncogênicas c-akt/genética
Transdução de Sinais/efeitos dos fármacos
Fator de Necrose Tumoral alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Hydrolyzable Tannins); 0 (Lipopolysaccharides); 0 (Neuroprotective Agents); 0 (Tumor Necrosis Factor-alpha); 0 (urolithin C); 1143-70-0 (3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b03285


  2 / 1947 MEDLINE  
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[PMID]:29262676
[Au] Autor:Suvanto J; Tähtinen P; Valkamaa S; Engström MT; Karonen M; Salminen JP
[Ad] Endereço:Natural Chemistry Research Group, Department of Chemistry, University of Turku , FI-20014, Turku, Finland.
[Ti] Título:Variability in Foliar Ellagitannins of Hippophaë rhamnoides L. and Identification of a New Ellagitannin, Hippophaenin C.
[So] Source:J Agric Food Chem;66(3):613-620, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Berries of common sea-buckthorn (Hippophaë rhamnoides L.) are well-known and used for their bioactive components, and while there is a considerable amount of research on the leaves as well, their ellagitannins (ETs) have not been a prominent focus of research. We identified and quantified ten major hydrophilic polyphenols, all ETs, in H. rhamnoides leaves and compared their abundance between 58 plant individuals. Of these compounds, hippophaenin C was characterized as a new ellagitannin by various spectrometric methods. The total concentrations of ETs ranged from 42.5 mg g dry weight (DW) to 109.1 mg g DW between individual plants. Among the ETs, hippophaenin C, stachyurin, and casuarinin were on average the most abundant compounds. Sexes did not differ significantly, while cultivars showed variation in some ETs. These results suggest that H. rhamnoides leaves could be a potential and rich source of several ETs.
[Mh] Termos MeSH primário: Hippophae/química
Taninos Hidrolisáveis/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Espectrometria de Massas
Estrutura Molecular
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (ellagitannin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04834


  3 / 1947 MEDLINE  
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[PMID]:28454190
[Au] Autor:Piwowarski JP; Bobrowska-Korczak B; Stanislawska I; Bielecki W; Wrzesien R; Granica S; Krupa K; Kiss AK
[Ad] Endereço:Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Poland.
[Ti] Título:Evaluation of the Effect of Epilobium angustifolium Aqueous Extract on LNCaP Cell Proliferation in In Vitro and In Vivo Models.
[So] Source:Planta Med;83(14-15):1159-1168, 2017 Oct.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:sp. are commonly used in traditional medicine in the treatment of early stages of benign prostatic hyperplasia and inflammation. It is suggested that a dominating constituent, oenothein B, is responsible for the extracts therapeutic effects. Several bioactivities were established for extracts and oenothein B in various models, but due to the questionable bioavailability of this dimeric macrocyclic ellagitannin, their significance in the effects remains unresolved. We have thus focused our attention on a complex comparative investigation of the and activities of phytochemically characterized aqueous extract and oenothein B on prostate cancer cells proliferation.Incubation of different cell lines with aqueous extract resulted in a significant reduction of proliferation of PZ-HPV-7 and LNCaP cells, which was partly associated with antiandrogenic activity. These effects were fully congruent with oenothein B, examined in parallel. Oral supplementation of rats implanted with LNCaP cells with aqueous extract 50-200 mg/kg b. w. resulted in a reduction of the occurrence of prostatic adenoma up to 13 %. Oenothein B was not detected in the urine and feces of the aqueous extract-treated group, however, conjugates of nasutins gut microbiota metabolites of ellagitannins were detected in the urine, while in human volunteers supplemented with tea, only urolithin conjugates were present.Despite observing significant and consistent effects and , we were unable to point out unequivocally the factors contributing to the observed aqueous extract activity, facing the problems of an unknown metabolic fate of oenothein B and interspecies differences in aqueous extract gut microbiota metabolism.
[Mh] Termos MeSH primário: Epilobium/química
Taninos Hidrolisáveis/farmacologia
Extratos Vegetais/farmacologia
Hiperplasia Prostática/tratamento farmacológico
Neoplasias da Próstata/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Seres Humanos
Inflamação/tratamento farmacológico
Masculino
Medicina Tradicional
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Polifenóis/farmacologia
Ratos
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (Polyphenols); 0 (ellagitannin); 059QF0KO0R (Water); 104987-36-2 (oenothein B)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-109372


  4 / 1947 MEDLINE  
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[PMID]:28455553
[Au] Autor:Nakano F; Miyoshi S; Murakami T
[Ad] Endereço:Maruzen Pharmaceuticals Co.Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, Hiroshima, 729-3102, Japan. f-nakano@maruzenpcy.co.jp.
[Ti] Título:New ellagitannins from Tiencha and their inhibitory activity against dental plaque.
[So] Source:J Nat Med;71(3):545-552, 2017 Jul.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Four new galloyl-oxygen-diphenyl (GOD)-type ellagitannins, brambliins A-D (1-4), were isolated from the leaves of Rubus suavissimus. Their structures were elucidated by extensive spectroscopic analyses and the absolute configurations of 1-4 were determined by chemical and phytochemical evidence. These GOD-type ellagitannins inhibited the formation of dental plaque, which is beneficial for oral hygiene.
[Mh] Termos MeSH primário: Placa Dentária
Taninos Hidrolisáveis/farmacologia
Extratos Vegetais/farmacologia
Rubus/química
[Mh] Termos MeSH secundário: Taninos Hidrolisáveis/química
Taninos Hidrolisáveis/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-017-1090-9


  5 / 1947 MEDLINE  
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[PMID]:28835347
[Au] Autor:Park EJ; Lee D; Baek SE; Kim KH; Kang KS; Jang TS; Lee HL; Song JH; Yoo JE
[Ad] Endereço:Department of Obstetrics and Gynaecology, College of Korean Medicine, Daejeon University, Daejeon 35235, Republic of Korea.
[Ti] Título:Cytotoxic effect of sanguiin H-6 on MCF-7 and MDA-MB-231 human breast carcinoma cells.
[So] Source:Bioorg Med Chem Lett;27(18):4389-4392, 2017 09 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sanguiin H-6 is a dimer of casuarictin linked by a bond between the gallic acid residue and one of the hexahydroxydiphenic acid units. It is an effective compound extracted from Rubus coreanus. It has an anticancer effect against several human cancer cells; however, its effect on breast cancer cells has not been clearly demonstrated. Thus, we aimed to investigate the anticancer effect and mechanism of action of sanguiin H-6 against two human breast carcinoma cell lines (MCF-7 and MDA-MB-231). We found that sanguiin H-6 significantly reduced cell viability in a concentration-dependent manner. It also increased the rates at which MCF-7 and MDA-MB-231 cells underwent apoptosis. Furthermore, sanguiin H-6 induced the cleavage of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, which resulted in apoptosis. However, cleavage of caspase-9 was only detectable in MCF-7 cells. In addition, sanguiin H-6 increased the ratio of Bax to Bcl-2 in both MCF-7 and MDA-MB-231 cells. These findings suggest that sanguiin H-6 is a potent therapeutic agent against breast cancer cells. In addition, it exerts its anticancer effect in an estrogen-receptor-independent manner.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Taninos Hidrolisáveis/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Taninos Hidrolisáveis/síntese química
Taninos Hidrolisáveis/química
Células MCF-7
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Hydrolyzable Tannins); 82978-00-5 (sanguiin H 6)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


  6 / 1947 MEDLINE  
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[PMID]:28731232
[Au] Autor:Grochowski DM; Skalicka-Wozniak K; Orhan IE; Xiao J; Locatelli M; Piwowarski JP; Granica S; Tomczyk M
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Bialystok, Bialystok, Poland.
[Ti] Título:A comprehensive review of agrimoniin.
[So] Source:Ann N Y Acad Sci;1401(1):166-180, 2017 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin--dimeric ellagitannin--is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. (Rosaceae), a plant traditionally used in Japan and China as an antidiarrheal, hemostatic, and antiparasitic agent. Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures. It is also present in commonly consumed food products, such as strawberries and raspberries. It is metabolized by human gut microbiota into a series of low-molecular-weight urolithins with proven anti-inflammatory and anticancer in vivo and in vitro bioactivities. The compound has received widespread interest owing to some interesting biological effects and therapeutic activities, which we elaborate in the present review. Additionally, we present an overview of the techniques used for the analysis, isolation, and separation of agrimoniin from the practical perspective.
[Mh] Termos MeSH primário: Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Rosaceae
[Mh] Termos MeSH secundário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Seres Humanos
Taninos Hidrolisáveis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); 82203-01-8 (agrimoniin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13421


  7 / 1947 MEDLINE  
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[PMID]:28709945
[Au] Autor:Adaramoye O; Erguen B; Nitzsche B; Höpfner M; Jung K; Rabien A
[Ad] Endereço:Department of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Drug Metabolism and Toxicology Section, Department of Biochemistry, University of Ibadan, Nigeria. Electronic address: aoadaramoye@yahoo.com.
[Ti] Título:Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells.
[So] Source:Chem Biol Interact;274:100-106, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Prostate cancer (PCa) is an international health problem and search for its effective treatment is in progress. Punicalagin (PN), polyphenol from pomegranate fruit, is known to exhibit potent anticancer activity in lung, breast and cervical cells. However, there is paucity of information on its effect in PCa. This study evaluated anti-proliferative effects of PN and its effects on extrinsic pathway of apoptosis in PCa cells, and angiogenesis in chicken chorioallantoic membrane (CAM). Antioxidant activities of PN were determined by 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging and inhibition of lipid peroxidation (LPO) methods. PCa (PC-3 and LNCaP) and normal prostate (BPH-1) cells were cultured and treated with PN (10, 50 and 100 µM). Cytotoxicity and viability effects of PN were determined by lactate dehydrogenase (LDH) and XTT assays, respectively. Antiangiogenic effects were measured using CAM assay, while apoptosis was assessed by DNA fragmentation, enrichment factor by Cell Death Detection ELISA kit and expressions of caspases-3 and -8. Results showed that PN (10-200 µM) significantly scavenged DPPH and inhibited LPO in a concentration-dependent manner. Furthermore, PN (10-100 µM) concentration-dependently inhibited viability in PC-3 and LNCaP, while viability in BPH-1 was insignificantly affected. PN had low toxicity on cells in vitro at concentrations tested. Also, PN (100 µM) increased enrichment factor in PC-3 (2.34 ± 0.05) and LNCaP (2.31 ± 0.26) relative to control (1.00 ± 0.00). In addition, PN (50 µM) decreased the network of vessels in CAM, suggesting its anti-angiogenic effect. Moreso, PN increased the expressions of caspases-3 and -8 in PC-3. Overall, PN exerts anti-proliferative activity in PCa cells via induction of apoptosis and anti-angiogenic effect.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Taninos Hidrolisáveis/farmacologia
Extratos Vegetais/química
Punicaceae/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Caspase 3/análise
Caspase 8/análise
Linhagem Celular Tumoral
Fragmentação do DNA/efeitos dos fármacos
Frutas/química
Frutas/metabolismo
Seres Humanos
Taninos Hidrolisáveis/química
Taninos Hidrolisáveis/isolamento & purificação
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Neovascularização Fisiológica/efeitos dos fármacos
Polifenóis/química
Punicaceae/metabolismo
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (Polyphenols); 65995-63-3 (punicalagin); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 8)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


  8 / 1947 MEDLINE  
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[PMID]:28659035
[Au] Autor:Bing SJ; Cho J; Kim A; Herath KHINM; Ahn G; Lee NH; Park JW; Jee Y
[Ad] Endereço:* Department of Veterinary Medicine and Institute for Nuclear Science & Technology, Jeju National University, Jeju 63243, South Korea.
[Ti] Título:Geraniin Promotes Recovery of Hematopoietic Cells after Radiation Injury.
[So] Source:Am J Chin Med;45(5):1003-1016, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Cells of the hematopoietic system are uniquely radiosensitive due to their rapid proliferation. Consequently, immune suppression readily and undesirably results from irradiation. Our previous studies demonstrated that geraniin isolated from Nymphaea tetragona var. angusta (water lily) had a protective effect on the splenocytes and intestinal tract of irradiated mice. This study was designed to assess the effectiveness of geraniin, an ellagitannin isolated from the water lily, in decreasing gamma ray irradiation-induced destruction of the hematopoietic system in mice. Geraniin treatment improved the survival time of bone marrow cells and maintained bone marrow integrity and also up-regulated the expression of stem cell receptors and the extent of cell mitosis. Geraniin also enhanced the proliferation and differentiation of immune cells that had been suppressed by irradiation. These results suggest geraniin is a promising agent for reconstituting hematopoietic cells after exposure to irradiation.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/efeitos da radiação
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/efeitos da radiação
Glucosídeos/farmacologia
Células-Tronco Hematopoéticas/citologia
Taninos Hidrolisáveis/farmacologia
Lesões Experimentais por Radiação/tratamento farmacológico
Protetores contra Radiação/farmacologia
[Mh] Termos MeSH secundário: Animais
Células da Medula Óssea
Células Cultivadas
Raios gama/efeitos adversos
Glucosídeos/administração & dosagem
Glucosídeos/isolamento & purificação
Glucosídeos/uso terapêutico
Células-Tronco Hematopoéticas/efeitos da radiação
Taninos Hidrolisáveis/administração & dosagem
Taninos Hidrolisáveis/isolamento & purificação
Taninos Hidrolisáveis/uso terapêutico
Injeções Intraperitoneais
Camundongos Endogâmicos C57BL
Nymphaea/química
Fitoterapia
Lesões Experimentais por Radiação/patologia
Protetores contra Radiação/uso terapêutico
Baço/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Hydrolyzable Tannins); 0 (Radiation-Protective Agents); 0 (ellagitannin); 60976-49-0 (Geraniin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500537


  9 / 1947 MEDLINE  
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[PMID]:28648053
[Au] Autor:Gong Y; Pegg RB
[Ad] Endereço:Department of Food Science & Technology, College of Agricultural and Environmental Sciences, The University of Georgia , 100 Cedar Street, Athens, Georgia 30602, United States.
[Ti] Título:Separation of Ellagitannin-Rich Phenolics from U.S. Pecans and Chinese Hickory Nuts Using Fused-Core HPLC Columns and Their Characterization.
[So] Source:J Agric Food Chem;65(28):5810-5820, 2017 Jul 19.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:U.S. pecans and Chinese hickory nuts possess a wide array of phenolic constituents with potential health benefits including phenolic acids and proanthocyanidins. Only limited information is available, however, on their compositions. The present study optimized the separation performance and characterized the low-molecular-weight phenolic fractions of these nuts with C18 and pentafluorophenyl (PFP) fused-core LC columns by employing a kinetic approach. Although both types of reversed-phase columns demonstrated similar performance in general, the PFP column furnished greater plate numbers and superior peak shapes for the low-molecular-weight fractions as well as overall separations of ellagic acid derivatives. The high-molecular-weight fraction of pecans, analyzed by a 3-µm HILIC column, possessed more proanthocyanidins than the Chinese hickory nuts with dimers and trimers (31.4 and 18.34 mg/g crude extract, respectively) being present at the greatest levels. Chinese hickory nuts had lower proanthocyanidin content but possessed tetramers and pentamers at 4.46 and 4.01 mg/g crude extract, respectively.
[Mh] Termos MeSH primário: Carya/química
Taninos Hidrolisáveis/análise
Nozes/química
Fenóis/análise
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: China
Cromatografia Líquida de Alta Pressão
Taninos Hidrolisáveis/isolamento & purificação
Fenóis/isolamento & purificação
Extratos Vegetais/isolamento & purificação
Proantocianidinas/análise
Proantocianidinas/isolamento & purificação
Estados Unidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrolyzable Tannins); 0 (Phenols); 0 (Plant Extracts); 0 (Proanthocyanidins); 0 (ellagitannin); 18206-61-6 (proanthocyanidin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01597


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[PMID]:28640298
[Au] Autor:Pinela J; Prieto MA; Antonio AL; Carvalho AM; Oliveira MBPP; Barros L; Ferreira ICFR
[Ad] Endereço:Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, 1172, 5300-253 Bragança, Portugal. iferreira@ipb.pt.
[Ti] Título:Ellagitannin-rich bioactive extracts of Tuberaria lignosa: insights into the radiation-induced effects in the recovery of high added-value compounds.
[So] Source:Food Funct;8(7):2485-2499, 2017 Jul 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ellagitannins are polyphenols responsible for a number of bioactivities and health-promoting effects. These industrially important molecules can be affected by post-harvest treatments and recovery processes, but little is known about the irradiation-induced effects on their integrity, bioactivity and extractability. Herein, the impact of gamma radiation on the production of ellagitannin-rich extracts was investigated using Tuberaria lignosa as a case study. These effects were compared with those induced in flavonoids and organic acids. The extracts were particularly rich in hydrophilic antioxidants (measured by in vitro assays). The recovery of different phytochemicals was favoured by longer extraction times. Ellagitannins (mainly punicalagin derivatives) were extracted better from samples irradiated at 5 kGy and were not significantly affected by the 10 kGy dose. However, the total contents of flavonoids and organic acids were decreased by the consequent increase in irradiation dose. Therefore, this study supports the use of gamma radiation for processing T. lignosa, aiming to obtain ellagitannin-rich bioactive extracts.
[Mh] Termos MeSH primário: Antioxidantes/análise
Cistaceae/química
Cistaceae/efeitos da radiação
Taninos Hidrolisáveis/análise
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Raios gama
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (ellagitannin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00500h



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