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[PMID]:29229332
[Au] Autor:Aparicio I; Martín J; Abril C; Santos JL; Alonso E
[Ad] Endereço:Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011 Seville, Spain. Electronic address: iaparicio@us.es.
[Ti] Título:Determination of household and industrial chemicals, personal care products and hormones in leafy and root vegetables by liquid chromatography-tandem mass spectrometry.
[So] Source:J Chromatogr A;1533:49-56, 2018 Jan 19.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A multiresidue method has been developed for the determination of emerging pollutants in leafy and root vegetables. Selected compounds were 6 perfluoroalkyl compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), 3 non-ionic surfactants (nonylphenol and nonylphenolethoxylates), 8 anionic surfactants (4 alkylsulfates and 4 linear alkylbenzene sulfonates), 4 preservatives (parabens), 2 biocides (triclosan and triclocarban), 2 plasticizers (bisphenol A and di-(2-ethylhexyl)phthalate), 6 UV-filters (benzophenones) and 4 hormones. The method is based on ultrasound-assisted extraction, clean-up by dispersive solid-phase extraction (d-SPE) and liquid chromatography-tandem mass spectrometry analysis. Due to the diversity of the physico-chemical properties of the target compounds, and to better evaluate the influence of sample treatment variables in extraction efficiencies, Box-Behnken design was applied to optimize extraction solvent volume, number of extraction cycles and d-SPE sorbent amount. Linearity (R ) higher than 0.992, accuracy (expressed as relative recoveries) in the range from 81 to 126%, precision (expressed as relative standard deviation) lower than 19% and limits of detection between 0.025 and 12.5ngg dry weight were achieved. The method was applied to leafy vegetables (lettuce, spinach and chard) and root vegetables (carrot, turnip and potato) from a local market. The highest concentrations corresponded to the surfactants reaching levels up to 114ngg (dry weight), in one of the lettuce samples analyzed.
[Mh] Termos MeSH primário: Cromatografia Líquida
Poluentes Ambientais/análise
Análise de Alimentos/métodos
Hormônios/análise
Compostos Orgânicos/análise
Espectrometria de Massas em Tandem
Verduras/química
[Mh] Termos MeSH secundário: Ácidos Alcanossulfônicos/análise
Compostos Benzidrílicos/análise
Fluorcarbonetos/análise
Análise de Alimentos/normas
Limite de Detecção
Parabenos/análise
Fenóis/análise
Ácidos Ftálicos/análise
Plastificantes/análise
Conservantes Farmacêuticos/análise
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Benzhydryl Compounds); 0 (Environmental Pollutants); 0 (Fluorocarbons); 0 (Hormones); 0 (Organic Chemicals); 0 (Parabens); 0 (Phenols); 0 (Phthalic Acids); 0 (Plasticizers); 0 (Preservatives, Pharmaceutical); 0 (alkylbenzyl sulfonic acid); 6O7F7IX66E (phthalic acid); 79F6A2ILP5 (nonylphenol); 9H2MAI21CL (perfluorooctane sulfonic acid); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:29313327
[Au] Autor:Chai WM; Huang Q; Lin MZ; Ou-Yang C; Huang WY; Wang YX; Xu KL; Feng HL
[Ad] Endereço:College of Life Science and Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi Normal University , Nanchang, Jiangxi 330022, People's Republic of China.
[Ti] Título:Condensed Tannins from Longan Bark as Inhibitor of Tyrosinase: Structure, Activity, and Mechanism.
[So] Source:J Agric Food Chem;66(4):908-917, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, the content, structure, antityrosinase activity, and mechanism of longan bark condensed tannins were evaluated. The findings obtained from mass spectrometry demonstrated that longan bark condensed tannins were mixtures of procyanidins, propelargonidins, prodelphinidins, and their acyl derivatives (galloyl and p-hydroxybenzoate). The enzyme analysis indicated that these mixtures were efficient, reversible, and mixed (competitive is dominant) inhibitor of tyrosinase. What's more, the mixtures showed good inhibitions on proliferation, intracellular enzyme activity and melanogenesis of mouse melanoma cells (B ). From molecular docking, the results showed the interactions between inhibitors and tyrosinase were driven by hydrogen bond, electrostatic, and hydrophobic interactions. In addition, high levels of total phenolic and extractable condensed tannins suggested that longan bark might be a good source of tyrosinase inhibitor. This study would offer theoretical basis for the development of longan bark condensed tannins as novel food preservatives and medicines of skin diseases.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Monofenol Mono-Oxigenase/antagonistas & inibidores
Casca de Planta/química
Sapindaceae/química
Taninos/química
Taninos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antocianinas/farmacologia
Biflavonoides/farmacologia
Catequina/farmacologia
Proliferação Celular/efeitos dos fármacos
Ligações de Hidrogênio
Interações Hidrofóbicas e Hidrofílicas
Espectrometria de Massas
Melaninas/análise
Melaninas/antagonistas & inibidores
Melaninas/biossíntese
Melanoma Experimental
Camundongos
Modelos Moleculares
Simulação de Acoplamento Molecular
Oxirredutases
Parabenos/farmacologia
Proantocianidinas/farmacologia
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Eletricidade Estática
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Biflavonoids); 0 (Enzyme Inhibitors); 0 (Melanins); 0 (Parabens); 0 (Proanthocyanidins); 0 (Tannins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); EC 1.- (Oxidoreductases); EC 1.14.18.- (monophenolase); EC 1.14.18.1 (Monophenol Monooxygenase); EM6MD4AEHE (delphinidin); JG8Z55Y12H (4-hydroxybenzoic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05481


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[PMID]:28466639
[Au] Autor:Ding K; Kong X; Wang J; Lu L; Zhou W; Zhan T; Zhang C; Zhuang S
[Ad] Endereço:College of Environmental and Resource Sciences, Zhejiang University , Hangzhou 310058, China.
[Ti] Título:Side Chains of Parabens Modulate Antiandrogenic Activity: In Vitro and Molecular Docking Studies.
[So] Source:Environ Sci Technol;51(11):6452-6460, 2017 Jun 06.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parabens have been widely used in packaged foods, pharmaceuticals, and personal-care products. Considering their potential hydrolysis, we herein investigated structural features leading to the disruption of human androgen receptor (AR) and whether hydrolysis could alleviate such effects using the recombinant yeast two-hybrid assay. Parabens with an aryloxy side chain such as benzyl paraben and phenyl paraben have the strongest antiandrogenic activity. The antiandrogenic activity of parabens with alkyloxyl side chains decreases as the side chain length increases from 1 to 4, and no antiandrogenic effect occurred for heptyl, octyl, and dodecyl parabens with the number of alkoxyl carbon atoms longer than 7. The antiandrogenic activity of parabens correlates significantly with their binding energies (R = 0.84, p = 0.01) and were completely diminished after the hydrolysis, particularly for parabens with aryloxy side chains. The K for the hydrolysis of parabens with aromatic moiety side chain is 1 order of magnitude higher than that of the parabens with alkyl side chains. Both in vitro and in silico data, for the first time, suggest parabens with aromatic side chains are less prone to hydrolysis. Our results provide an insight into risk of various paraben and considerations for design of new paraben-related substitutes.
[Mh] Termos MeSH primário: Antagonistas de Androgênios
Simulação de Acoplamento Molecular
Parabenos/química
[Mh] Termos MeSH secundário: Seres Humanos
Hidrólise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgen Antagonists); 0 (Parabens)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b00951


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[PMID]:28973488
[Au] Autor:Xue P; Zhao X; Qin M; Shi Z; Zhang M; Gu W
[Ad] Endereço:College of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China.
[Ti] Título:Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling.
[So] Source:J Insect Sci;17(4), 2017 Jul 01.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ethylparaben (EP) has been shown to have estrogenic effects and can affect the normal development, longevity, and reproductive system of some animals. In this study, we investigated the effects of EP in male Drosophila melanogaster using transcriptome analysis or digital gene expression profiling. We then screened differentially expressed genes (DEGs) between the two groups (EP-treated and control group) of Drosophila, and performed clustering analysis, gene ontology (GO) function annotation, kyoto encyclopedia of gene and genomes metabolic pathway analysis. We found that EP enriched GO in three processes: cellular component, molecular function, and biological process. Consequently, we detected 13,959 genes and among them, 18 genes were identified to be significantly expressed between the EP-treated and control samples. Of these, seven genes were down-regulated, and eleven genes were up-regulated in EP-treated samples. Furthermore, four DEGs including two down-regulated genes (CG9465, CG9468) and two up-regulated genes (TotA, Sqz) were verified by real-time quantitative PCR. This study revealed the impact of EP on gene expression in fruit fly and provided new insight into the mechanisms of this response, which is helpful for understanding EP toxicity to humans.
[Mh] Termos MeSH primário: Drosophila melanogaster/efeitos dos fármacos
Drosophila melanogaster/metabolismo
Parabenos/toxicidade
[Mh] Termos MeSH secundário: Animais
Perfilação da Expressão Gênica
Masculino
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parabens); 14255EXE39 (ethyl-p-hydroxybenzoate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1093/jisesa/iex050


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[PMID]:28886595
[Au] Autor:Nassan FL; Coull BA; Gaskins AJ; Williams MA; Skakkebaek NE; Ford JB; Ye X; Calafat AM; Braun JM; Hauser R
[Ad] Endereço:Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, Massachusetts, USA.
[Ti] Título:Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study.
[So] Source:Environ Health Perspect;125(8):087012, 2017 08 18.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however, their contribution to men's exposure is understudied. OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men. METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a urine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use. RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, -value<0.01) and deodorant (74%, -value<0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/body lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant. CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that their use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. https://doi.org/10.1289/EHP1374.
[Mh] Termos MeSH primário: Cosméticos
Exposição Ambiental/estatística & dados numéricos
Substâncias Perigosas/urina
Parabenos/metabolismo
Ácidos Ftálicos/urina
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics); 0 (Hazardous Substances); 0 (Parabens); 0 (Phthalic Acids); 6O7F7IX66E (phthalic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1289/EHP1374


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[PMID]:28803111
[Au] Autor:Schroyen M; Van Hulle SWH; Holemans S; Vervaeren H; Raes K
[Ad] Endereço:Department of Industrial Biological Sciences, Faculty of Bioscience Engineering, Ghent University, Campus Kortrijk, Graaf Karel de Goedelaan 5, 8500 Kortrijk, Belgium.
[Ti] Título:Laccase enzyme detoxifies hydrolysates and improves biogas production from hemp straw and miscanthus.
[So] Source:Bioresour Technol;244(Pt 1):597-604, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The impact of various phenolic compounds, vanillic acid, ferulic acid, p-coumaric acid and 4-hydroxybenzoic acid on anaerobic digestion of lignocellulosic biomass (hemp straw and miscanthus) was studied. Such phenolic compounds have been known to inhibit biogas production during anaerobic digestion. The different phenolic compounds were added in various concentrations: 0, 100, 500, 1000 and 2000mg/L. A difference in inhibition of biomethane production between the phenolic compounds was noted. Hydrolysis rate, during anaerobic digestion of miscanthus was inhibited up to 50% by vanillic acid, while vanillic acid had no influence on the initial rate of biogas production during the anaerobic digestion of hemp straw. Miscanthus has a higher lignin concentration (12-30g/100gDM) making it less accessible for degradation, and in combination with phenolic compounds released after harsh pretreatments, it can cause severe inhibition levels during the anaerobic digestion, lowering biogas production. To counter the inhibition, lignin degrading enzymes can be used to remove or degrade the inhibitory phenolic compounds. The interaction of laccase and versatile peroxidase individually with the different phenolic compounds was studied to have insight in the polymerization of inhibitory compounds or breakdown of lignocellulose. Hemp straw and miscanthus were incubated with 0, 100 and 500mg/L of the different phenolic compounds for 0, 6 and 24h and pretreated with the lignin degrading enzymes. A laccase pretreatment successfully detoxified the substrate, while versatile peroxidase however was inhibited by 100mg/L of each of the individual phenolic compounds. Finally a combination of enzymatic detoxification and subsequent biogas production showed that a decrease in phenolic compounds by laccase treatment can considerably lower the inhibition levels of the biogas production.
[Mh] Termos MeSH primário: Biocombustíveis
Cannabis/química
Lacase
[Mh] Termos MeSH secundário: Ácidos Cumáricos
Lignina
Parabenos
Propionatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Coumaric Acids); 0 (Parabens); 0 (Propionates); 9005-53-2 (Lignin); EC 1.10.3.2 (Laccase); IBS9D1EU3J (trans-3-(4'-hydroxyphenyl)-2-propenoic acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


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[PMID]:28692926
[Au] Autor:Hossy BH; da Costa Leitão AA; Dos Santos EP; Matsuda M; Rezende LB; Rurr JSC; Pinto AV; Ramos-E-Silva M; de Pádula M; de Oliveira Miguel NC
[Ad] Endereço:Programa de Pós-Graduação em Clínica Médica, Faculdade de Medicina - Serviço de Dermatologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study.
[So] Source:J Photochem Photobiol B;173:545-550, 2017 Aug.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cosmetic preservatives are used to protect cosmetic formulations and improve its shelf-life. However, these substances may exert phototoxic effects when used under sunlight. OBJECTIVE: To assess safety, efficacy and putative phototoxic effects of a sunscreen formulation SPF 30 and its excipients. MATERIALS/METHODS: Irradiation was performed with solar simulated light (SSL) and the sunscreen from the School of Pharmacy/UFRJ/Brazil. We used albino hairless mice in different groups (control (G1), only irradiated (G2), sunscreen plus irradiation (G3) and vehicle plus irradiation (G4) for morphological assessment and immunefluorescence detection to OKL38. In vitro analyses were with a Saccharomyces cerevisiae (SC) strain plus SSL in the presence of methylparaben, propylparaben, imidazolidinyl urea, aminomethyl propanol and their association. RESULTS: G3 and G4 displayed photosensitization leading to thickening of the epidermis and increased dermal cellularity. G4 displayed strong OKL38 labeling when compared with other groups. Aminomethyl propanol, methylparaben and propylparaben are endowed with phototoxic activity against SC. Propylparaben displayed the highest phototoxic effect, followed by excipients association. CONCLUSIONS: The sunscreen's vehicle is endowed with phototoxic activity. Propylparaben was the most phototoxic agent, increasing the overall phototoxicity of excipient association, pointing to a critical concern regarding vehicle associations intended to cosmetic purposes.
[Mh] Termos MeSH primário: Pele/efeitos dos fármacos
Protetores Solares/farmacologia
[Mh] Termos MeSH secundário: Animais
Cosméticos
Composição de Medicamentos
Camundongos
Camundongos Pelados
Microscopia de Fluorescência
Parabenos/toxicidade
Propanolaminas/toxicidade
Saccharomyces cerevisiae/efeitos dos fármacos
Saccharomyces cerevisiae/efeitos da radiação
Pele/patologia
Pele/efeitos da radiação
Luz Solar
Ureia/análogos & derivados
Ureia/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics); 0 (Parabens); 0 (Propanolamines); 0 (Sunscreening Agents); 8W8T17847W (Urea); A2I8C7HI9T (methylparaben); LU49E6626Q (2-amino-2-methyl-1-propanol); M629807ATL (imidazolidinyl urea); Z8IX2SC1OH (propylparaben)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE


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[PMID]:28688846
[Au] Autor:Castro G; Rodríguez I; Ramil M; Cela R
[Ad] Endereço:Departamento de Química Analítica, Nutrición y Bromatología, Instituto de Investigación y Análisis Alimentario (IIAA), Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain.
[Ti] Título:Evaluation of nitrate effects in the aqueous photodegradability of selected phenolic pollutants.
[So] Source:Chemosphere;185:127-136, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of nitrate in the aqueous photodegradation of five phenolic environmental pollutants (ortho-phenylphenol, OPP; methyl paraben, MeP; propyl paraben, PrP; Triclosan, TCS and bisphenol A, BPA) is evaluated. Time-course of precursor compounds and formation of transformation products (TPs) were investigated by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Nitrate showed a positive effect in the removal of selected pollutants. Observed TPs resulted from hydroxylation, aromatic nitration (with or without molecule cleavage) and nitro dehalogenation processes. The above reactions involved the participation of ·OH and ·NO radicals arising from photolysis of nitrate. Nitro TPs were produced in a different extent depending on the structure of the precursor pollutant, nitrate concentration, light source (254 nm UV and solar light) and water matrix (ultrapure, surface and urban wastewater). Some of these nitro TPs were also observed during UV irradiation of untreated and unbuffered wastewater, either naturally polluted with parent phenolic compounds or spiked with these species at the sub µg L level. Nitration reactions were particularly favourable for OPP with the generated nitro TPs displaying a higher stability than the precursor molecule and the hydroxylated TPs of the same compound.
[Mh] Termos MeSH primário: Nitratos/química
Fenóis/química
Processos Fotoquímicos
[Mh] Termos MeSH secundário: Compostos Benzidrílicos
Cromatografia Líquida/métodos
Luz
Espectrometria de Massas
Nitratos/análise
Parabenos
Fotólise
Raios Ultravioleta
Águas Residuais/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Nitrates); 0 (Parabens); 0 (Phenols); 0 (Waste Water); 0 (Water Pollutants, Chemical); A2I8C7HI9T (methylparaben); MLT3645I99 (bisphenol A); Z8IX2SC1OH (propylparaben)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


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[PMID]:28527915
[Au] Autor:Hu P; Overby H; Heal E; Wang S; Chen J; Shen CL; Zhao L
[Ad] Endereço:Department of Nutrition, The University of Tennessee, Knoxville, TN, United States.
[Ti] Título:Methylparaben and butylparaben alter multipotent mesenchymal stem cell fates towards adipocyte lineage.
[So] Source:Toxicol Appl Pharmacol;329:48-57, 2017 Aug 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paraben esters and their salts are widely used as preservatives in cosmetics, personal care products, pharmaceuticals, and foods. We previously reported that parabens promoted adipocyte differentiation in vitro and increased adiposity but suppressed serum marker of bone formation in vivo. Here, we investigated the effects of parabens (methylparaben and butylparaben) on modulating cell fate of multipotent stem cell line C3H10T1/2. Both parabens modulated adipogenic, osteogenic, and chondrogenic differentiation of C3H10T1/2 cells in vitro. Butylparaben markedly promoted adipogenic differentiation, but suppressed osteogenic and chondrogenic differentiation whereas methylparaben showed similar but less pronounced effects. Moreover, butylparaben, but not methylparaben, was shown to activate peroxisome proliferator-activated receptor (PPAR) γ whereas neither of the paraben was shown to activate glucocorticoid receptor (GR) responsive reporter in C3H10T1/2 cells. The adipogenic effects of butylparaben were significantly attenuated by PPARγ knockdown, but not by GR knockdown. In contrast, paraben's effects on osteoblast differentiation were affected by both knockdowns. Collectively, the results demonstrate opposing effects of parabens on adipogenic and osteoblastogenic/chondrogenic differentiation of multipotent stem cells. In light of the recent findings that parabens are detected in human placenta and milk, our studies provide rationales to study paraben exposure during early development of life in the future.
[Mh] Termos MeSH primário: Adipócitos/efeitos dos fármacos
Adipogenia/efeitos dos fármacos
Linhagem da Célula
Células Mesenquimais Estromais/efeitos dos fármacos
Parabenos/toxicidade
[Mh] Termos MeSH secundário: Adipócitos/metabolismo
Adipócitos/patologia
Animais
Linhagem Celular
Condrogênese/efeitos dos fármacos
Células Mesenquimais Estromais/metabolismo
Células Mesenquimais Estromais/patologia
Camundongos Endogâmicos C3H
Osteogênese/efeitos dos fármacos
PPAR gama/agonistas
PPAR gama/genética
PPAR gama/metabolismo
Fenótipo
Interferência de RNA
Receptores de Glucocorticoides/efeitos dos fármacos
Receptores de Glucocorticoides/genética
Receptores de Glucocorticoides/metabolismo
Medição de Risco
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
Transfecção
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PPAR gamma); 0 (Parabens); 0 (Receptors, Glucocorticoid); 3QPI1U3FV8 (butylparaben); A2I8C7HI9T (methylparaben)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


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[PMID]:28527332
[Au] Autor:Hui-Ting Z; Ding EMC; Ding WH
[Ad] Endereço:Department of Chemistry, National Central University, Chung-Li 320, Taiwan.
[Ti] Título:Determination of parabens in human urine by optimal ultrasound-assisted emulsification microextraction and on-line acetylation gas chromatography-mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1058:14-18, 2017 Jul 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An effective and solvent-less method for the rapid determination of four commonly detected parabens (methyl-, ethyl-, propyl- and butyl-) in human urine samples is described. This method employed ultrasound-assisted emulsification microextraction (USAEME) before identification and quantitation of the parabens via on-line acetylation gas chromatography-mass spectrometry (GC-MS). Urine samples were enzymatically de-conjugated with ß-glucuronidase and then extracted by an optimal USAEME procedure for the measurement of total concentrations of target analytes. The optimal USAEME parameters for one mL of urine sample (containing 0.1-g of sodium chloride), according to the Box-Behnken design method, are thus described: extractant of 200-µL of ethyl acetate, and ultrasonication for 1.0min and centrifugation at 7000rpm (3min). The supernatant was collected and evaporated until dry. Then the residue was re-dissolved in methanol (100-µL), and the extract was subjected to on-line acetylation GC-MS analysis. The limits of quantitation (LOQs) were less than 0.06ng/mL. Precisions for both intra- and inter-day analysis were calculated, and were less than 8%. Mean extraction recovery (known as trueness) was between 83 and 101% on three concentration levels. In human urine, the total concentrations of the four selected parabens, according to preliminary results, range from 0.3 to 124.5ng/mL for male, and from 27.2 to 246.3ng/mL for female. Female urine samples showed higher concentrations for the target parabens, which may indicate higher exposure due to lifestyle. This method permits accurate and high-throughput analysis of parabens for epidemiological studies.
[Mh] Termos MeSH primário: Fracionamento Químico/métodos
Cromatografia Gasosa-Espectrometria de Massas/métodos
Parabenos/análise
Sonicação/métodos
[Mh] Termos MeSH secundário: Acetilação
Emulsões
Feminino
Seres Humanos
Masculino
Parabenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Parabens)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE



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