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[PMID]:29318311
[Au] Autor:Santaladchaiyakit Y; Bunchamnan J; Tongsa D; Srijaranai S
[Ti] Título:Methyl Salicylate-Based Vortex-Assisted Surfactant-Enhanced Emulsification Microextraction and HPLC for Determination of Fungicides in Honey Samples.
[So] Source:Acta Chim Slov;64(4):849-857, 2017 Dec.
[Is] ISSN:1318-0207
[Cp] País de publicação:Slovenia
[La] Idioma:eng
[Ab] Resumo:Methyl salicylate based vortex-assisted surfactant-enhanced emulsification microextraction (MeSA-VASEME) has been developed and applied for rapid preconcentration of fungicides (i.e., carbendazim, thiabendazole, and fluberidazole) in honey samples followed by high performance liquid chromatographic analysis. MeSA was used as an extraction solvent, while surfactant was used to enhance the extraction performance under the dispersion by vortex agitation. The optimum MeSA-VASEME conditions were 100 µL MeSA, 2.0 mmol L‒1 sodium dodecyl sulfate, and vortex agitation at 1200 rpm for 90 s. Preconcentration factors were obtained in the range of 32-40. The limit of detection in the studied honey samples was 0.5 µg L‒1. The recovery of the spiked target fungicides at 20, 50, and 100 µg L‒1 were 81.5-116.8 % with the relative standard deviation below 11%. The proposed method is simple, sensitive, less organic solvent consuming, inexpensive, and a rapid procedure for the residue analysis of fungicides in honey samples.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Fungicidas Industriais/análise
Mel/análise
Microextração em Fase Líquida/métodos
[Mh] Termos MeSH secundário: Emulsões
Concentração de Íons de Hidrogênio
Salicilatos/química
Solventes/química
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Fungicides, Industrial); 0 (Salicylates); 0 (Solvents); 0 (Surface-Active Agents); LAV5U5022Y (methyl salicylate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:29289264
[Au] Autor:Meng Z; Huang R
[Ad] Endereço:Department of Orthopaedics, First People's Hospital of YunNan Province, Kunming, YunNan, P.R. China.
[Ti] Título:Topical Treatment of Degenerative Knee Osteoarthritis.
[So] Source:Am J Med Sci;355(1):6-12, 2018 01.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy. Current treatment guidelines recommend topical nonsteroidal anti-inflammatory drugs as an alternative and even first-line therapy for OA management, especially among elderly patients. Guidelines on other topical treatments vary, from recommendations against their use, to in favor as alternative or simultaneous therapy, especially for patients with contraindications to other analgesics. Although often well-tolerated and preferred by many patients, clinical care still lags in the adoption of topical treatments. Aspects of efficacy, safety and patient quality of life data require further research.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Capsaicina/administração & dosagem
Osteoartrite do Joelho/tratamento farmacológico
Guias de Prática Clínica como Assunto/normas
Salicilatos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Tópica
Analgésicos/administração & dosagem
Seres Humanos
Osteoartrite do Joelho/diagnóstico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Salicylates); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  3 / 10568 MEDLINE  
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[PMID]:29182277
[Au] Autor:Keszycka PK; Szkop M; Gajewska D
[Ad] Endereço:Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, and ‡Department of Biochemistry, Faculty of Agriculture and Biology, Warsaw University of Life Sciences-SGGW , Nowoursynowska 159, 02-776 Warsaw, Poland.
[Ti] Título:Overall Content of Salicylic Acid and Salicylates in Food Available on the European Market.
[So] Source:J Agric Food Chem;65(50):11085-11091, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The study aimed to determine the salicylates content in 112 products available on the European market. Quantitative determination of free and conjugated forms of salicylic acid in food was performed using reversed-phase high-performance liquid chromatography with fluorescence detection. The salicylates contents ranged from 0 to 1675.79 (µg/100 g). The results of this study confirm the presence of salicylates in food products, as well as a broad content diversity of these compounds depending on the species, variety, and method of processing the food items. The results can be very helpful for nutritionists and dieticians in planning low-salicylates or high-salicylates diets.
[Mh] Termos MeSH primário: Carne/análise
Óvulo/química
Extratos Vegetais/análise
Plantas/química
Salicilatos/análise
Ácido Salicílico/análise
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Europa (Continente)
Alimentos/economia
Análise de Alimentos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Salicylates); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04313


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[PMID]:27776888
[Au] Autor:Shchegol'kov EV; Shchur IV; Burgart YV; Saloutin VI; Trefilova AN; Ljushina GA; Solodnikov SY; Markova LN; Maslova VV; Krasnykh OP; Borisevich SS; Khursan SL
[Ad] Endereço:Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Science, S. Kovalevskoy Str., 22, Ekaterinburg 620990 Russia. Electronic address: schegolkov@ios.uran.ru.
[Ti] Título:Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation.
[So] Source:Bioorg Med Chem;25(1):91-99, 2017 01 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
[Mh] Termos MeSH primário: Analgésicos/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Inibidores de Ciclo-Oxigenase/uso terapêutico
Edema/tratamento farmacológico
Salicilatos/uso terapêutico
[Mh] Termos MeSH secundário: Analgésicos/química
Analgésicos/farmacocinética
Analgésicos/farmacologia
Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/farmacocinética
Anti-Inflamatórios não Esteroides/farmacologia
Ciclo-Oxigenase 1/metabolismo
Inibidores de Ciclo-Oxigenase/química
Inibidores de Ciclo-Oxigenase/farmacocinética
Inibidores de Ciclo-Oxigenase/farmacologia
Feminino
Halogenação
Masculino
Simulação de Acoplamento Molecular
Ratos Sprague-Dawley
Ratos Wistar
Salicilatos/química
Salicilatos/farmacocinética
Salicilatos/farmacologia
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cyclooxygenase Inhibitors); 0 (Salicylates); EC 1.14.99.1 (Cyclooxygenase 1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  5 / 10568 MEDLINE  
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[PMID]:28923384
[Au] Autor:Ebrahimipour SY; Mohamadi M; Torkzadeh Mahani M; Simpson J; Mague JT; Sheikhshoaei I
[Ad] Endereço:Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address: Ebrahimipour@ymail.com.
[Ti] Título:Synthesis and structure elucidation of novel salophen-based dioxo-uranium(VI) complexes: In-vitro and in-silico studies of their DNA/BSA-binding properties and anticancer activity.
[So] Source:Eur J Med Chem;140:172-186, 2017 Nov 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The synthesis and characterization of three dioxo U(VI) complexes, [UO (L )(OH )], [UO (L )DMF], and [UO (L )DMSO], [L ] = 1,1'-(4-methyl-1,2-phenylenebis (nitrilomethylidyne))di-2-naphtholate: [L ] = 1,1'-(o-phenylenebis (nitrilomethylidyne)) di-2-naphtholate, are reported. Elemental analysis, FT-IR, HNMR, UV-Vis spectroscopy, molar conductivity and single crystal X-ray diffraction were used to characterize the complexes. It was found that the complexes adopt a distorted pentagonal bipyramidal coordination geometry. The interaction of the synthesized complexes with DNA and bovine serum albumin was thoroughly investigated using both experimental and theoretical studies. UV-Vis absorption and fluorescence quenching techniques were applied to determine the binding parameters as well as the mechanism of the interaction of each complex with DNA and the protein. The results obtained suggested that interaction of the complexes with DNA occurred through partial intercalation into the minor grooves of DNA with binding constants in the range of 0.661 × 10 -1.56 × 10 M . In addition, interaction of the complexes with bovine serum albumin quenched the fluorescence emission of the tryptophan residues of the protein binding constants and thermodynamic parameters were obtained from the fluorescence quenching experiments at different temperatures. The values of binding constants revealed moderate interactions between the synthesized complexes and the protein suggesting that this protein could act as a suitable vehicle for transportation of the compounds. The results of molecular docking confirmed those of the experimental studies. The anticancer properties of the title complexes were also evaluated through a study of the in vitro cytotoxicity of the compounds against the HT-29 and MCF-7 cancer cell lines and the DPSC normal cell line using an MTT assay.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Compostos Organometálicos/farmacologia
Salicilatos/farmacologia
Urânio/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Sítios de Ligação/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
DNA de Neoplasias/química
DNA de Neoplasias/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Modelos Moleculares
Estrutura Molecular
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Salicilatos/química
Soroalbumina Bovina/química
Soroalbumina Bovina/efeitos dos fármacos
Relação Estrutura-Atividade
Termodinâmica
Células Tumorais Cultivadas
Urânio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (DNA, Neoplasm); 0 (Organometallic Compounds); 0 (Salicylates); 118-57-0 (salophen); 27432CM55Q (Serum Albumin, Bovine); 4OC371KSTK (Uranium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:28826779
[Au] Autor:Tsuchiyama H; Maeda A; Nakajima M; Kitsukawa M; Takahashi K; Miyoshi T; Mutsuga M; Asaoka Y; Miyamoto Y; Oshida K
[Ad] Endereço:Pharmaceutical Research Laboratories, Toray Industries Inc., 10-1, Tebiro 6-chome, Kamakura, Kanagawa, 248-8555, Japan.
[Ti] Título:Gene expression profiles in auricle skin as a possible additional endpoint for determination of sensitizers: A multi-endpoint evaluation of the local lymph node assay.
[So] Source:Toxicol Lett;280:133-141, 2017 Oct 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The murine local lymph node assay (LLNA) is widely used to test chemicals to induce skin sensitization. Exposure of mouse auricle skin to a sensitizer results in proliferation of local lymph node T cells, which has been measured by in vivo incorporation of H -methyl thymidine or 5-bromo-2'-deoxyuridine (BrdU). The stimulation index (SI), the ratio of the mean proliferation in each treated group to that in the concurrent vehicle control group, is frequently used as a regulatory-authorized endpoint for LLNA. However, some non-sensitizing irritants, such as sodium dodecyl sulfate (SDS) or methyl salicylate (MS), have been reported as false-positives by this endpoint. In search of a potential endpoint to enhance the specificity of existing endpoints, we evaluated 3 contact sensitizers; (hexyl cinnamic aldehyde [HCA], oxazolone [OXA], and 2,4-dinitrochlorobenzene [DNCB]), 1 respiratory sensitizer (toluene 2,4-diisocyanate [TDI]), and 2 non-sensitizing irritants (MS and SDS) by several endpoints in LLNA. Each test substance was applied to both ears of female CBA/Ca mice daily for 3 consecutive days. The ears and auricle lymph node cells were analyzed on day 5 for endpoints including the SI value, lymph node cell count, cytokine release from lymph node cells, and histopathological changes and gene expression profiles in auricle skin. The SI values indicated that all the test substances induced significant proliferation of lymph node cells. The lymph node cell counts showed no significant changes by the non-sensitizers assessed. The inflammatory findings of histopathology were similar among the auricle skins treated by sensitizers and irritants. Gene expression profiles of cytokines IFN-γ, IL-4, and IL-17 in auricle skin were similar to the cytokine release profiles in draining lymph node cells. In addition, the gene expression of the chemokine CXCL1 and/or CXCL2 showed that it has the potential to discriminate sensitizers and non-sensitizing irritants. Our results suggest that multi-endpoint analysis in the LLNA leads to a better determination of the sensitizing potential of test substances. We also show that the gene expression of CXCL1 and/or CXCL2, which is involved in elicitation of contact hypersensitivity (CHS), can be a possible additional endpoint for discrimination of sensitizing compounds in LLNA.
[Mh] Termos MeSH primário: Pavilhão Auricular/metabolismo
Ensaio Local de Linfonodo
Pele/metabolismo
Transcriptoma/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Citocinas/genética
Citocinas/metabolismo
Dinitroclorobenzeno/toxicidade
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos CBA
Oxazolona/toxicidade
Salicilatos/toxicidade
Dodecilsulfato de Sódio/toxicidade
Tolueno 2,4-Di-Isocianato/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Salicylates); 15646-46-5 (Oxazolone); 17X7AFZ1GH (Toluene 2,4-Diisocyanate); 368GB5141J (Sodium Dodecyl Sulfate); 78243HXH5O (2,6-diisocyanatotoluene); GE3IBT7BMN (Dinitrochlorobenzene); LAV5U5022Y (methyl salicylate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE


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[PMID]:28818753
[Au] Autor:Kamatham S; Pallu R; Pasupulati AK; Singh SS; Gudipalli P
[Ad] Endereço:Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India.
[Ti] Título:Benzoylsalicylic acid derivatives as defense activators in tobacco and Arabidopsis.
[So] Source:Phytochemistry;143:160-169, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Systemic acquired resistance (SAR) is a long lasting inducible whole plant immunity often induced by either pathogens or chemical elicitors. Salicylic acid (SA) is a known SAR signal against a broad spectrum of pathogens in plants. In a recent study, we have reported that benzoylsalicylic acid (BzSA) is a SAR inducer in tobacco and Arabidopsis plants. Here, we have synthesized BzSA derivatives using SA and benzoyl chlorides of various moieties as substrates. The chemical structures of BzSA derivatives were elucidated using Infrared spectroscopy (IR), Nuclear magnetic spectroscopy (NMR) and High-resolution mass spectrometer (HRMS) analysis. The bioefficacy of BzSA derivatives in inducing defense response against tobacco mosaic virus (TMV) was investigated in tobacco and SA abolished transgenic NahG Arabidopsis plants. Interestingly, pre-treatment of local leaves of tobacco with BzSA derivatives enhanced the expression of SAR genes such as NPR1 [Non-expressor of pathogenesis-related (PR) genes 1], PR and other defense marker genes (HSR203, SIPK, WIPK) in systemic leaves. Pre-treatment of BzSA derivatives reduced the spread of TMV infection to uninfected areas by restricting lesion number and diameter both in local and systemic leaves of tobacco in a dose-dependent manner. Furthermore, pre-treatment of BzSA derivatives in local leaves of SA deficient Arabidopsis NahG plants induced SAR through AtPR1 and AtPR5 gene expression and reduced leaf necrosis and curling symptoms in systemic leaves as compared to BzSA. These results suggest that BzSA derivatives are potent SAR inducers against TMV in tobacco and Arabidopsis.
[Mh] Termos MeSH primário: Arabidopsis/metabolismo
Salicilatos/farmacologia
Tabaco/metabolismo
[Mh] Termos MeSH secundário: Arabidopsis/genética
Índia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Plantas Geneticamente Modificadas
Salicilatos/química
Ácido Salicílico/metabolismo
Tabaco/genética
Vírus do Mosaico do Tabaco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Salicylates); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


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[PMID]:28738415
[Au] Autor:Sun YC; Liou HM; Yeh PT; Chen WL; Hu FR
[Ad] Endereço:Department of Ophthalmology, Taipei Tzu Chi Hospital, the Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan 2Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
[Ti] Título:Monocarboxylate Transporters Mediate Fluorescein Uptake in Corneal Epithelial Cells.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3716-3722, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To determine the presence of monocarboxylate transporter (MCT) in human and rabbit corneal epithelium and its role in transcellular fluorescein transportation in the cornea. Methods: The presence of MCTs in human and rabbit corneal epithelium was determined by RT-PCR and immunohistochemistry. Intracellular fluorescein uptake experiment was performed using cultured human corneal epithelial cells (HCECs). The involvement of MCT in fluorescein uptake was determined by addition of MCT inhibitors to HCECs and acute dry eye model on New Zealand albino rabbits by spectrophotometry, corneal impression cytology, and external eye photographs. Results: MCT-1 and MCT-4 were identified in both human and rabbit corneal epithelia. A longer treatment period and a lower pH value in culture medium increased fluorescein uptake in HCECs. Fluorescein uptake in HCECs was decreased following addition of MCT inhibitors in a concentration-dependent manner. Impression cytology under fluorescent microscopy showed intracellular fluorescein staining in the rabbit cornea with acute dry eye treatment that was decreased following topical treatment of MCT inhibitors. Conclusions: Fluorescein ingress in corneal epithelial cells is mediated by the MCT family. Further study of MCT-mediated transport on HCECs may potentially benefit differential diagnosis and contribute better understandings of ocular surface disorders.
[Mh] Termos MeSH primário: Epitélio Anterior/metabolismo
Fluoresceína/metabolismo
Corantes Fluorescentes/metabolismo
Transportadores de Ácidos Monocarboxílicos/metabolismo
Proteínas Musculares/metabolismo
Simportadores/metabolismo
[Mh] Termos MeSH secundário: Ácido 4,4'-Di-Isotiocianoestilbeno-2,2'-Dissulfônico/farmacologia
Doença Aguda
Animais
Transporte Biológico/fisiologia
Células Cultivadas
Relação Dose-Resposta a Droga
Síndromes do Olho Seco/metabolismo
Síndromes do Olho Seco/patologia
Seres Humanos
Concentração de Íons de Hidrogênio
Imuno-Histoquímica
Microscopia de Fluorescência
Transportadores de Ácidos Monocarboxílicos/antagonistas & inibidores
Proteínas Musculares/antagonistas & inibidores
Coelhos
Reação em Cadeia da Polimerase em Tempo Real
Salicilatos/farmacologia
Simportadores/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); 0 (Monocarboxylic Acid Transporters); 0 (Muscle Proteins); 0 (SLC16A4 protein, human); 0 (Salicylates); 0 (Symporters); 0 (monocarboxylate transport protein 1); Q1O6DSW23R (4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid); TPY09G7XIR (Fluorescein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20998


  9 / 10568 MEDLINE  
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[PMID]:28625729
[Au] Autor:Wang JF; Liang R; Liao SR; Yang B; Tu ZC; Lin XP; Wang BG; Liu Y
[Ad] Endereço:CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Key Laboratory of Experimental Marine Biology, Institu
[Ti] Título:Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii.
[So] Source:Fitoterapia;120:164-170, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ten new salicyloid derivatives, namely vaccinols J-S (1-10), along with five known compounds (11-15) were isolated from Pestalotiopsis vaccinii (cgmcc3.9199) endogenous with the mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). Their structures including absolute configurations were established on the basis of spectroscopic analysis, optical rotation, CD spectra, quantum ECD calculations. To the best of our knowledge, vaccinol J (1) is the first example of salicyloid derivatives containing 2-methylfuran moiety. All of the new compounds were tested for their anti-enterovirus 7l (EV71) and cytotoxic activities. Among them, vaccinol J (1) exhibited in vitro anti-EV71 with IC value of 30.7µM (IC 177.0µM for the positive control ribavirin).
[Mh] Termos MeSH primário: Rhizophoraceae/microbiologia
Salicilatos/farmacologia
Xylariales/química
[Mh] Termos MeSH secundário: Antivirais/isolamento & purificação
Antivirais/farmacologia
Linhagem Celular Tumoral
Enterovirus Humano A/efeitos dos fármacos
Seres Humanos
Estrutura Molecular
Salicilatos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Salicylates)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


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[PMID]:28600687
[Au] Autor:Rowen E; Gutensohn M; Dudareva N; Kaplan I
[Ad] Endereço:Department of Entomology, Pennsylvania State University, University Park, PA, 16802, USA. epr5119@psu.edu.
[Ti] Título:Carnivore Attractant or Plant Elicitor? Multifunctional Roles of Methyl Salicylate Lures in Tomato Defense.
[So] Source:J Chem Ecol;43(6):573-585, 2017 Jun.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Synthetic plant volatile lures attract natural enemies, but may have non-target effects due to the multifunctional nature of volatile signals. For example, methyl salicylate (MeSA) is used to attract predators, yet also serves as a signaling hormone involved in plant pathogen defense. We investigated the consequences of deploying MeSA lures to attract predators for tomato (Solanum lycopersicum) defense against herbivores. To understand the spatial distribution of the lure's effect, we exposed tomatoes in the field to MeSA along a linear distance gradient and induced defenses by simulating feeding by hornworm caterpillars in a fully crossed factorial design (+/- MeSA, +/- herbivory). Subsequently, we analyzed activity of several defensive proteins (protease inhibitors, polyphenol oxidase, peroxidase), development of hornworm larvae (Manduca sexta), growth of fungal pathogens (Cladosporium and Alternaria), and attractiveness to herbivores and predators. Overall, MeSA-exposed plants were more resistant to both insects and pathogens. Secondary pathogen infection was reduced by 25% in MeSA exposed plants, possibly due to elevated polyphenol oxidase activity. Interestingly, we found that lures affected plant pathogen defenses equivalently across all distances (up to 4 m away) indicating that horizontal diffusion of a synthetic volatile may be greater than previously assumed. While thrips avoided colonizing hornworm- damaged tomato plants, this induced resistance was not observed upon pre-exposure to MeSA, suggesting that MeSA suppresses the repellant effect induced by herbivory. Thus, using MeSA lures in biological control may inadvertently protect crops from pathogens, but has mixed effects on plant resistance to insect herbivores.
[Mh] Termos MeSH primário: Herbivoria
Lycopersicon esculentum
Manduca/fisiologia
Salicilatos/química
Salicilatos/farmacologia
[Mh] Termos MeSH secundário: Alternaria/crescimento & desenvolvimento
Animais
Catecol Oxidase/metabolismo
Cladosporium/crescimento & desenvolvimento
Larva/fisiologia
Lycopersicon esculentum/metabolismo
Lycopersicon esculentum/microbiologia
Peroxidase/metabolismo
Controle Biológico de Vetores
Folhas de Planta/microbiologia
Inibidores de Proteases/metabolismo
Espectrometria de Massas em Tandem
Compostos Orgânicos Voláteis/química
Compostos Orgânicos Voláteis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protease Inhibitors); 0 (Salicylates); 0 (Volatile Organic Compounds); EC 1.10.3.1 (Catechol Oxidase); EC 1.11.1.7 (Peroxidase); LAV5U5022Y (methyl salicylate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0856-6



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