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[PMID]:28233902
[Au] Autor:Siddiqui MT; Litts JK; Cheney DM; Kuhn MA; Nativ-Zeltzer N; Belafsky PC
[Ad] Endereço:Department of Otolaryngology, University of California, Davis, Sacramento, California, U.S.A.
[Ti] Título:The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model.
[So] Source:Laryngoscope;127(5):E148-E152, 2017 May.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: Contrast agents are an integral component of the video fluoroscopic swallow study. Agents commonly used include barium sulfate (E-Z Paque), iodixanol (Visipaque), and diatrizoic acid (Gastrografin). Barium is water insoluble, whereas iodixanol and diatrizoic acid are water-soluble iodine-based agents. The detrimental effect of these agents on the lungs has not been systematically evaluated. Our aim was to evaluate and compare the effects of aspirated barium, iodixanol, and diatrizoic acid on pulmonary injury in a lagomorph model. STUDY DESIGN: Animal model. METHODS: Twenty adult male New Zealand White rabbits were divided into four groups (n = 5). Group 1 received 3 mL of barium sulfate injected into the trachea for 3 consecutive days. Group 2 received 3 mL of iodixanol injected into the trachea for 3 consecutive days. Group 3 received 3 mL of diatrizoic acid injected into the trachea for 3 consecutive days. A control group received 3 mL of air injected into the trachea under an identical protocol. All animals were euthanized on day 4, and the lung and trachea were harvested for blinded histopathologic analysis. The primary outcome measure was survival. The secondary endpoint was a blinded, histologic grading system of lung injury. RESULTS: Two animals in the barium group, one in the diatrizoic acid group, and 0 animals in the iodixanol and control groups died. The overall lung injury score for the barium (60.60 ± 6.34) and iodixanol groups (52.30 ± 3.11) were significantly higher (worse) than the diatrizoic acid (49.60 ± 7.64) and control groups (37.80 ± 3.56) (P < .05). Diatrizoic acid produced the least amount of lung injury. CONCLUSIONS: The data suggest that 3 mL of aspirated barium sulfate (E-Z Paque) over 3 consecutive days causes more severe lung injury in a lagomorph model than 3 mL of aspirated iodixanol (Visipaque) and diatrizoic acid (Gastrografin). Diatrizoic acid caused the least histologic evidence of lung injury. LEVEL OF EVIDENCE: NA Laryngoscope, 127:E148-E152, 2017.
[Mh] Termos MeSH primário: Sulfato de Bário/envenenamento
Meios de Contraste/envenenamento
Diatrizoato/envenenamento
Lesão Pulmonar/induzido quimicamente
Ácidos Tri-Iodobenzoicos/envenenamento
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Lesão Pulmonar/mortalidade
Masculino
Coelhos
Aspiração Respiratória
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Triiodobenzoic Acids); 117-96-4 (Diatrizoate); 25BB7EKE2E (Barium Sulfate); 5UVC90J1LK (diatrizoic acid); HW8W27HTXX (iodixanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26494


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[PMID]:27460216
[Au] Autor:Fawaz EM; El-Rahman MK; Riad SM; Shehata MA
[Ad] Endereço:Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, 11562, Cairo, Egypt.
[Ti] Título:Monitoring of the degradation kinetics of diatrizoate sodium to its cytotoxic degradant using a stability-indicating high-performance liquid chromatographic method.
[So] Source:Biomed Chromatogr;31(2), 2017 Feb.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The X-ray diagnostic agent sodium diatrizoate (DTA) was studied for chemical degradation. The 3,5-diamino derivative was found to be the alkaline and acidic degradation product. The 3,5-diamino degradate is also the synthetic precursor of DTA and it is proved to have cytotoxic and mutagenic effects. A sensitive, selective and precise high-performance liquid chromatographic stability-indicating method for the determination of DTA in the presence of its acidic degradation product and in pharmaceutical formulation was developed and validated. Owing to the high toxicity of the degradation product, the kinetics of the acidic degradation process was monitored by the developed RP-HPLC method. The reaction was found to follow pseudo-first order kinetics. The kinetic parameters such as rate constant (K) and half-life (t ) were calculated under different temperatures and acid concentrations; activation energy was estimated from the Arrhenius plot. The developed RP-HPLC method depends on isocratic elution of a mobile phase composed of methanol-water (25:75 v/v; pH adjusted with phosphoric acid), and UV detection at 238 nm. The method showed good linearity over a concentration range of 2-100 µg/mL with mean percentage recovery of 100.04 ± 1.07. The selectivity of the proposed method was tested using laboratory-prepared mixtures. The proposed method has been successfully applied to the analysis of DTA in pharmaceutical dosage forms without interference from other dosage form additives and the results were statistically compared with the official USP method. Validation of the proposed method was performed according to International Conference on Harmonization guidelines.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Meios de Contraste/metabolismo
Diatrizoato/metabolismo
[Mh] Termos MeSH secundário: Meios de Contraste/análise
Meios de Contraste/toxicidade
Diatrizoato/análise
Diatrizoato/toxicidade
Estabilidade de Medicamentos
Seres Humanos
Cinética
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 117-96-4 (Diatrizoate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3799


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[PMID]:27681105
[Au] Autor:Azaïs A; Mendret J; Petit E; Brosillon S
[Ad] Endereço:Institut Européen des Membranes, Université Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.
[Ti] Título:Influence of volumetric reduction factor during ozonation of nanofiltration concentrates for wastewater reuse.
[So] Source:Chemosphere;165:497-506, 2016 Dec.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Global population growth induces increased threat on drinking water resources. One way to address this environmental issue is to reuse water from wastewater treatment plant. The presence of pathogenic microorganisms and potentially toxic organic micropollutants does not allow a direct reuse of urban effluents. Membrane processes such reverse osmosis (RO) or nanofiltration (NF) can be considered to effectively eliminate these pollutants. The integration of membrane processes involves the production of concentrated retentates which require being disposed. To date, no treatment is set up to manage safely this pollution. This work focuses on the application of ozonation for the treatment of NF retentates in the framework of the wastewater reuse. Ozonation is a powerful oxidation process able to react and degrade a wide range of organic pollutants. Four pharmaceutical micropollutants were selected as target molecules: acetaminophen, carbamazepine, atenolol and diatrozic acid. This study highlighted that NF represents a viable alternative to the commonly used RO process ensuring high retention at much lower operating costs. Ozonation appears to be effective to degrade the most reactive pollutants toward molecular ozone but is limited for the reduction of refractory ozone pollutants due to the inhibition of the radical chain by the high content of organic matter in the retentates. The ozonation process appears to be a promising NF retentate treatment, but additional treatments after ozonation are required to lead to a zero liquid discharge treatment scheme.
[Mh] Termos MeSH primário: Filtração/métodos
Oxidantes/química
Ozônio/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Acetaminofen/química
Atenolol/química
Carbamazepina/química
Diatrizoato/química
Nanotecnologia
Oxirredução
Reciclagem
Eliminação de Resíduos Líquidos
Águas Residuais/química
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxidants); 0 (Waste Water); 0 (Water Pollutants, Chemical); 117-96-4 (Diatrizoate); 33CM23913M (Carbamazepine); 362O9ITL9D (Acetaminophen); 50VV3VW0TI (Atenolol); 5UVC90J1LK (diatrizoic acid); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE


  4 / 2932 MEDLINE  
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[PMID]:27654222
[Au] Autor:Schoutteten KVKM; Hennebel T; Dheere E; Bertelkamp C; De Ridder DJ; Maes S; Chys M; Van Hulle SWH; Vanden Bussche J; Vanhaecke L; Verliefde ARD
[Ad] Endereço:Laboratory of Particle and Interfacial Technology (PaInT), Department of Applied Analytical and Physical Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium. Electronic address: Klaas.Schoutteten@UGent.be.
[Ti] Título:Effect of oxidation and catalytic reduction of trace organic contaminants on their activated carbon adsorption.
[So] Source:Chemosphere;165:191-201, 2016 Dec.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The combination of ozonation and activated carbon (AC) adsorption is an established technology for removal of trace organic contaminants (TrOCs). In contrast to oxidation, reduction of TrOCs has recently gained attention as well, however less attention has gone to the combination of reduction with AC adsorption. In addition, no literature has compared the removal behavior of reduction vs. ozonation by-products by AC. In this study, the effect of pre-ozonation vs pre-catalytic reduction on the AC adsorption efficiency of five TrOCs and their by-products was compared. All compounds were susceptible to oxidation and reduction, however the catalytic reductive treatment proved to be a slower reaction than ozonation. New oxidation products were identified for dinoseb and new reduction products were identified for carbamazepine, bromoxynil and dinoseb. In terms of compatibility with AC adsorption, the influence of the oxidative and reductive pretreatments proved to be compound dependent. Oxidation products of bromoxynil and diatrizoic acid adsorbed better than their parent TrOCs, but oxidation products of atrazine, carbamazepine and dinoseb showed a decreased adsorption. The reductive pre-treatment showed an enhanced AC adsorption for dinoseb and a major enhancement for diatrizoic acid. For atrazine and bromoxynil, no clear influence on adsorption was noted, while for carbamazepine, the reductive pretreatment resulted in a decreased AC affinity. It may thus be concluded that when targeting mixtures of TrOCs, a trade-off will undoubtedly have to be made towards overall reactivity and removal of the different constituents, since no single treatment proves to be superior to the other.
[Mh] Termos MeSH primário: 2,4-Dinitrofenol/análogos & derivados
Atrazina/metabolismo
Carbamazepina/metabolismo
Diatrizoato/metabolismo
Recuperação e Remediação Ambiental/métodos
Nitrilos/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: 2,4-Dinitrofenol/metabolismo
Adsorção
Catálise
Carvão Vegetal/química
Oxirredução
Ozônio/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitriles); 0 (Water Pollutants, Chemical); 117-96-4 (Diatrizoate); 16291-96-6 (Charcoal); 33CM23913M (Carbamazepine); 5UVC90J1LK (diatrizoic acid); 66H7ZZK23N (Ozone); J46EK95K0P (bromoxynil); Q13SKS21MN (2,4-Dinitrophenol); QJA9M5H4IM (Atrazine); YD44ZEM22M (dinoseb)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


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[PMID]:27494698
[Au] Autor:Azerrad SP; Lütke Eversloh C; Gilboa M; Schulz M; Ternes T; Dosoretz CG
[Ad] Endereço:Faculty of Civil and Environmental Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
[Ti] Título:Identification of transformation products during advanced oxidation of diatrizoate: Effect of water matrix and oxidation process.
[So] Source:Water Res;103:424-434, 2016 Oct 15.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Removal of micropollutants from reverse osmosis (RO) brines of wastewater desalination by oxidation processes is influenced by the scavenging capacity of brines components, resulting in the accumulation of transformation products (TPs) rather than complete mineralization. In this work the iodinated contrast media diatrizoate (DTZ) was used as model compound due to its relative resistance to oxidation. Identification of TPs was performed in ultrapure water (UPW) and RO brines applying nonthermal plasma (NTP) and UVA-TiO2 as oxidation techniques. The influence of main RO brines components in the formation and accumulation of TPs, such as chloride, bicarbonate alkalinity and humic acid, was also studied during UVA-TiO2. DTZ oxidation pattern in UPW resulted similar in both UVA-TiO2 and NTP achieving 66 and 61% transformation, respectively. However, DTZ transformation in RO brines was markedly lower in UVA-TiO2 (9%) than in NTP (27%). These differences can be attributed to the synergic effect of RO brines components during NTP. Moreover, reactive species other than hydroxyl radical contributed to DTZ transformation, i.e., direct photolysis in UVA-TiO2 and direct photolysis + O3 in NTP accounted for 16 and 23%, respectively. DTZ transformation led to iodide formation in both oxidation techniques but it further oxidized to iodate by ozone in NTP. In total 14 transformation products were identified in UPW of which 3 were present only in UVA-TiO2 and 2 were present exclusively in NTP; 5 of the 14 TPs were absent in RO brines. Five of them were new and were denoted as TP-474A/B, TP-522, TP-586, TP-602, TP-628. TP-522 (mono-chlorinated) was elucidated only in presence of high chloride titer-synthetic water matrix in NTP, most probably formed by active chlorine species generated in situ. TPs accumulation in RO brines was markedly different in comparison to UPW. This denotes the influence of RO brines components in the formation of reactive species that could further attack DTZ/TPs and/or scavenging performed by these brine components that could limit further TPs degradation. Five plausible degradation pathways are proposed for DTZ transformation in UPW.
[Mh] Termos MeSH primário: Diatrizoato
Água
[Mh] Termos MeSH secundário: Oxirredução
Fotólise
Águas Residuais
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Waste Water); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 117-96-4 (Diatrizoate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


  6 / 2932 MEDLINE  
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[PMID]:27349786
[Au] Autor:Bocos E; Oturan N; Pazos M; Sanromán MÁ; Oturan MA
[Ad] Endereço:Department of Chemical Engineering, University of Vigo, Isaac Newton Building, Campus As Lagoas Marcosende, 36310, Vigo, Spain.
[Ti] Título:Elimination of radiocontrast agent diatrizoic acid by photo-Fenton process and enhanced treatment by coupling with electro-Fenton process.
[So] Source:Environ Sci Pollut Res Int;23(19):19134-44, 2016 Oct.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The removal of radiocontrast agent diatrizoic acid (DIA) from water was performed using photo-Fenton (PF) process. First, the effect of H2O2 dosage on mineralization efficiency was determined using ultraviolet (UV) irradiation. The system reached a maximum mineralization degree of 60 % total organic carbon (TOC) removal at 4 h with 20 mM initial H2O2 concentration while further concentration values led to a decrease in TOC abatement efficiency. Then, the effect of different concentrations of Fenton's reagents was studied for homogeneous Fenton process. Obtained results revealed that 0.25 mM Fe(3+) and 20 mM H2O2 were the best conditions, achieving 80 % TOC removal efficiency at 4 h treatment. Furthermore, heterogeneous PF treatment was developed using iron-activated carbon as catalyst. It was demonstrated that this catalyst is a promising option, reaching 67 % of TOC removal within 4 h treatment without formation of iron leachate in the medium. In addition, two strategies of enhancement for process efficiency are proposed: coupling of PF with electro-Fenton (EF) process in two ways: photoelectro-Fenton (PEF) or PF followed by EF (PF-EF) treatments, achieving in both cases the complete mineralization of DIA solution within only 2 h. Finally, the Microtox tests revealed the formation of more toxic compounds than the initial DIA during PF process, while, it was possible to reach total mineralization by both proposed alternatives (PEF or PF-EF) and thus to remove the toxicity of DIA solution.
[Mh] Termos MeSH primário: Meios de Contraste/química
Peróxido de Hidrogênio/química
Ferro/química
Processos Fotoquímicos
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Catálise
Meios de Contraste/análise
Diatrizoato
Oxirredução
Raios Ultravioleta
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Fenton's reagent); 0 (Water Pollutants, Chemical); 117-96-4 (Diatrizoate); 5UVC90J1LK (diatrizoic acid); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7054-x


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[PMID]:27010251
[Au] Autor:Johnson B; Hinshaw JL; Robbins JB; Pickhardt PJ
[Ad] Endereço:1 All authors: Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252.
[Ti] Título:Objective and Subjective Intrapatient Comparison of Iohexol Versus Diatrizoate for Bowel Preparation Quality at CT Colonography.
[So] Source:AJR Am J Roentgenol;206(6):1202-7, 2016 Jun.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study is to objectively and subjectively compare nonionic iohexol and ionic diatrizoate iodinated oral contrast agents as part of a cathartic bowel regimen within the same CT colonography (CTC) cohort, with otherwise identical preparations. MATERIALS AND METHODS: In this retrospective study, 46 adults with no symptoms (mean age, 59.4 years; 26 men and 20 women) returning for follow-up CTC over a 9-month interval underwent the same bowel preparation with the exception of 75 mL of iohexol 350 in place of 60 mL of diatrizoate. All other preparation components (bisacodyl, magnesium citrate, and 2% barium) remained constant. Objective volumetric analysis of residual colonic fluid volume and fluid attenuation was performed. Additionally, two radiologists experienced with CTC who were blinded to the specific bowel preparation scored each of six colonic segments for adherent residual solid stool using a previously validated 4-point scale (0 for no stool; 1-3 for increasing residual stool). A paired t test was used for comparison of the cohorts. RESULTS: No clear clinically meaningful difference was found between the two preparations on overall objective or subjective evaluation. The mean (± SD) residual fluid volume was 173 ± 126 mL with the iohexol preparation and 130 ± 79 mL with the diatrizoate preparation (p = 0.02). The mean total colonic stool score was 2.5 (0.42/segment) with iohexol and 2.3 (0.38/segment) with diatrizoate (p = 0.69). The mean fluid attenuation was higher with iohexol (849 ± 270 HU) compared with diatrizoate (732 ± 168 HU) (p = 0.03). CONCLUSION: On the basis of this direct intrapatient comparison, we found that oral iohexol is a suitable alternative to diatrizoate for fluid tagging as part of a cathartic bowel preparation at CTC. Because this nonionic tagging agent is more palatable, less expensive, and likely safer than ionic diatrizoate, our CTC program now uses iohexol as the standard recommended regimen.
[Mh] Termos MeSH primário: Catárticos
Colonografia Tomográfica Computadorizada
Meios de Contraste
Diatrizoato
Iohexol
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cathartics); 0 (Contrast Media); 117-96-4 (Diatrizoate); 4419T9MX03 (Iohexol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160325
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.15.15373


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[PMID]:26938498
[Au] Autor:Radjenovic J; Petrovic M
[Ad] Endereço:Catalan Institute for Water Research (ICRA), Emili Grahit 101, 17003 Girona, Spain. Electronic address: jradjenovic@icra.cat.
[Ti] Título:Sulfate-mediated electrooxidation of X-ray contrast media on boron-doped diamond anode.
[So] Source:Water Res;94:128-35, 2016 May 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Recently, electrochemical activation of sulfate ions to sulfate radical species and nonradically activated persulfate has been demonstrated at boron-doped diamond (BDD) anode, which enhanced the electrooxidation kinetics of several persistent contaminants. In this study, we investigated the transformation pathways of two X-ray contrast media (ICM), diatrizoate and iopromide, in electrooxidation at BDD anode using sulfate and inert nitrate anolyte. Sulfate anolyte yielded a seven-fold increase in apparent rate constants for ICM oxidation compared to inert nitrate anolyte, and a two-fold increase for the removal of organic carbon. Higher iodine release was observed in electrooxidation of diatrizoate compared to iopromide. In the case of diatrizoate, around 80% of deiodination efficiency was achieved in both anolytes. Deiodination efficiency of iopromide was somewhat lower in nitrate anolyte (≤75%) and significantly reduced in sulfate anolyte (≤46%) due to a larger steric hindrance of alkyl side chains. Moreover, a considerable lag phase of iopromide deiodination was observed in sulfate anolyte, indicating that initial oxidation reactions took place almost exclusively at the alkyl side chains. Several transformation products (TPs) of ICM were identified in electrooxidation in sulfate anolyte, and only three TPs in the case of nitrate anolyte. The main mechanistic steps in the oxidation of iopromide were H-abstraction and bond cleavage in the alkyl side chains. Diatrizoate was mainly transformed through oxidative cleavage of iodine substituent and inter-molecular cyclization. Two hydroxylamine derivatives of iopromide and a nitro-derivative of diatrizoate were observed in sulfate anolyte. These products have not been reported previously for hydroxyl radical-mediated oxidation of ICM. Given that electron-transfer mechanism is more typical for sulfate than for hydroxyl radicals, formation of hydroxylamine and nitro-derivatives of ICM was assigned to one-electron charge transfer to sulfate radical species and formation of N-centered radicals.
[Mh] Termos MeSH primário: Boro/química
Meios de Contraste/química
Diamante/química
Sulfatos/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Diatrizoato/química
Eletroquímica
Eletrodos
Halogenação
Radical Hidroxila/química
Iohexol/análogos & derivados
Iohexol/química
Nitratos/química
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 0 (Nitrates); 0 (Sulfates); 0 (Water Pollutants, Chemical); 0 (sulfate radical); 117-96-4 (Diatrizoate); 3352-57-6 (Hydroxyl Radical); 4419T9MX03 (Iohexol); 712BAC33MZ (iopromide); 7782-40-3 (Diamond); N9E3X5056Q (Boron)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160304
[St] Status:MEDLINE


  9 / 2932 MEDLINE  
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[PMID]:26874446
[Au] Autor:Batisse F; Schmitt A; Vendeuvre T; Herbreteau D; Bonnard C
[Ad] Endereço:Service de chirurgie orthopédique et traumatologie, CHU de Poitiers, 1, rue de la Milétrie, 86021 Poitiers, France. Electronic address: francoisbatisse@hotmail.com.
[Ti] Título:Aneurysmal bone cyst: A 19-case series managed by percutaneous sclerotherapy.
[So] Source:Orthop Traumatol Surg Res;102(2):213-6, 2016 Apr.
[Is] ISSN:1877-0568
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Sclerotherapy offers an alternative to surgery for the treatment of aneurysmal bone cyst (ABC). The main objective of the present study was to assess the radiological efficacy of sclerotherapy in terms of ossification on MRI. Secondary objectives were to assess clinical efficacy on pain evaluation and to analyze recurrence and complications according to type of sclerosing agent and intraoperative imaging technique. MATERIALS AND METHODS: Between 2006 and 2014, 19 patients (7 females, 12 males, aged 3 to 17 years) with ABC treated by sclerotherapy were included. Six received Ethibloc(®), 9 Aetoxisclerol(®), 2 liquid absolute alcohol, and 2 absolute alcohol gel. Assessment used fluoroscopy in 17 cases and CT in 2. Ossification was assessed on MRI and pain on a visual analog scale and HEDEN score. RESULTS: Ossification was complete in 11 cases (84.6%) and partial in 2 (15.4%). Eighteen patients (94.7%) were pain-free at 3 months. There was no recurrence, at a minimum 2 years' follow-up. One case of skin necrosis was observed, associated with use of liquid absolute alcohol; there was 1 case of arterial reflux of Ethibloc(®) under CT control. DISCUSSION: Sclerotherapy enables minimally invasive treatment of lesions that are deep, difficult of access to surgery and potentially damaging. Use of absolute alcohol gel and fluoroscopic control seems to improve the risk/benefit ratio, limiting complications by vascular extravasation of the sclerosing agent, thanks to real-time visualization of diffusion. Its clinical and radiological efficacy makes sclerotherapy and alternative primary treatment choice in ABC. LEVEL OF EVIDENCE: IV, retrospective study.
[Mh] Termos MeSH primário: Cistos Ósseos Aneurismáticos/terapia
Soluções Esclerosantes/uso terapêutico
Escleroterapia
[Mh] Termos MeSH secundário: Adolescente
Cistos Ósseos Aneurismáticos/complicações
Cistos Ósseos Aneurismáticos/diagnóstico por imagem
Criança
Pré-Escolar
Diatrizoato/uso terapêutico
Combinação de Medicamentos
Etanol/uso terapêutico
Ácidos Graxos/uso terapêutico
Feminino
Fluoroscopia
Seguimentos
Seres Humanos
Masculino
Dor Musculoesquelética/etiologia
Dor Musculoesquelética/terapia
Osteogênese
Medição da Dor
Polietilenoglicóis/uso terapêutico
Propilenoglicóis/uso terapêutico
Recidiva
Estudos Retrospectivos
Soluções Esclerosantes/efeitos adversos
Escleroterapia/efeitos adversos
Resultado do Tratamento
Zeína/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Fatty Acids); 0 (Propylene Glycols); 0 (Sclerosing Solutions); 0AWH8BFG9A (polidocanol); 117-96-4 (Diatrizoate); 30IQX730WE (Polyethylene Glycols); 3K9958V90M (Ethanol); 9010-66-6 (Zein); 91196-33-7 (alcoholic prolamine solution)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160215
[St] Status:MEDLINE


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[PMID]:26865110
[Au] Autor:Ha H; Mahanty B; Yoon S; Kim CG
[Ad] Endereço:a Department of Environmental Engineering , INHA University , Incheon , South Korea.
[Ti] Título:Degradation of the long-resistant pharmaceutical compounds carbamazepine and diatrizoate using mixed microbial culture.
[So] Source:J Environ Sci Health A Tox Hazard Subst Environ Eng;51(6):467-71, 2016.
[Is] ISSN:1532-4117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The microbial degradation of two recalcitrant pharmaceutical compounds, carbamazepine (CBZ) and diatrizoate (DTZ), was studied in laboratory batch experiments. We used a defined mixed microbial culture comprising four distinct microbial species that were previously known to have high decomposition capacity toward recalcitrant substances. Biological decomposition in liquid phase cultures for either CBZ or DTZ, or in a combination of the two, was conducted for 12 days. DTZ and CBZ were degraded by 43.2% and 60%, respectively from an initial concentration of 100 µg L(-1). When degradation was assessed using a mixture of the two compounds, the initial degradation rates of CBZ and DTZ were lower than those observed in the single-compound study. However, the final cumulative removal efficiency was very similar. The extent of dissolved organic carbon (DOC) removal was correlated with the degradation of the pharmaceuticals.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Carbamazepina/análise
Carbamazepina/metabolismo
Células Cultivadas/metabolismo
Diatrizoato/análise
Diatrizoato/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
República da Coreia
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 117-96-4 (Diatrizoate); 33CM23913M (Carbamazepine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160212
[St] Status:MEDLINE
[do] DOI:10.1080/10934529.2015.1128712



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