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Pesquisa : D02.241.223.100.400.880.410 [Categoria DeCS]
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[PMID]:28774606
[Au] Autor:Jeong CH; Machek EJ; Shakeri M; Duirk SE; Ternes TA; Richardson SD; Wagner ED; Plewa MJ
[Ad] Endereço:Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: cjeong@wisc.edu.
[Ti] Título:The impact of iodinated X-ray contrast agents on formation and toxicity of disinfection by-products in drinking water.
[So] Source:J Environ Sci (China);58:173-182, 2017 Aug.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The presence of iodinated X-ray contrast media (ICM) in source waters is of high concern to public health because of their potential to generate highly toxic disinfection by-products (DBPs). The objective of this study was to determine the impact of ICM in source waters and the type of disinfectant on the overall toxicity of DBP mixtures and to determine which ICM and reaction conditions give rise to toxic by-products. Source waters collected from Akron, OH were treated with five different ICMs, including iopamidol, iopromide, iohexol, diatrizoate and iomeprol, with or without chlorine or chloramine disinfection. The reaction product mixtures were concentrated with XAD resins and the mammalian cell cytotoxicity and genotoxicity of the reaction mixture concentrates was measured. Water containing iopamidol generated an enhanced level of mammalian cell cytotoxicity and genotoxicity after disinfection. While chlorine disinfection with iopamidol resulted in the highest cytotoxicity overall, the relative iopamidol-mediated increase in toxicity was greater when chloramine was used as the disinfectant compared with chlorine. Four other ICMs (iopromide, iohexol, diatrizoate, and iomeprol) expressed some cytotoxicity over the control without any disinfection, and induced higher cytotoxicity when chlorinated. Only iohexol enhanced genotoxicity compared to the chlorinated source water.
[Mh] Termos MeSH primário: Meios de Contraste/análise
Desinfetantes/análise
Água Potável/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Meios de Contraste/química
Desinfetantes/toxicidade
Desinfecção/métodos
Halogenação
Iohexol/análogos & derivados
Iohexol/análise
Iohexol/química
Iopamidol/análogos & derivados
Iopamidol/análise
Iopamidol/química
Poluentes Químicos da Água/química
Poluentes Químicos da Água/toxicidade
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Disinfectants); 0 (Drinking Water); 0 (Water Pollutants, Chemical); 17E17JBP8L (iomeprol); 4419T9MX03 (Iohexol); 712BAC33MZ (iopromide); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28731812
[Au] Autor:Shibata E; Takao H; Amemiya S; Ohtomo K
[Ad] Endereço:1 All authors: Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hono, Bunkyo-ku, Tokyo 113-8655, Japan.
[Ti] Título:3D-Printed Visceral Aneurysm Models Based on CT Data for Simulations of Endovascular Embolization: Evaluation of Size and Shape Accuracy.
[So] Source:AJR Am J Roentgenol;209(2):243-247, 2017 Aug.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this study is to verify the accuracy of 3D-printed hollow models of visceral aneurysms created from CT angiography (CTA) data, by evaluating the sizes and shapes of aneurysms and related arteries. SUBJECTS AND METHODS: From March 2006 to August 2015, 19 true visceral aneurysms were embolized via interventional radiologic treatment provided by the radiology department at our institution; aneurysms with bleeding (n = 3) or without thin-slice (< 1 mm) preembolization CT data (n = 1) were excluded. A total of 15 consecutive true visceral aneurysms from 11 patients (eight women and three men; mean age, 61 years; range, 53-72 years) whose aneurysms were embolized via endovascular procedures were included in this study. Three-dimensional-printed hollow models of aneurysms and related arteries were fabricated from CTA data. The accuracies of the sizes and shapes of the 3D-printed hollow models were evaluated using the nonparametric Wilcoxon signed rank test and the Dice coefficient index. RESULTS: Aneurysm sizes ranged from 138 to 18,691 mm (diameter, 6.1-35.7 mm), and no statistically significant difference was noted between patient data and 3D-printed models (p = 0.56). Shape analysis of whole aneurysms and related arteries indicated a high level of accuracy (Dice coefficient index value, 84.2-95.8%; mean [± SD], 91.1 ± 4.1%). CONCLUSION: The sizes and shapes of 3D-printed hollow visceral aneurysm models created from CTA data were accurate. These models can be used for simulations of endovascular treatment and precise anatomic information.
[Mh] Termos MeSH primário: Aneurisma/terapia
Angiografia por Tomografia Computadorizada
Modelos Anatômicos
Impressão Tridimensional
Radiografia Intervencionista
Vísceras/irrigação sanguínea
[Mh] Termos MeSH secundário: Idoso
Artérias
Meios de Contraste
Embolização Terapêutica
Procedimentos Endovasculares
Feminino
Seres Humanos
Iohexol
Iopamidol
Masculino
Meia-Idade
Interpretação de Imagem Radiográfica Assistida por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 4419T9MX03 (Iohexol); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.17694


  3 / 2627 MEDLINE  
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[PMID]:28720415
[Au] Autor:Eddy K; Costa AF
[Ad] Endereço:Department of Diagnostic Radiology, QE II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
[Ti] Título:Assessment of Cirrhotic Liver Enhancement With Multiphasic Computed Tomography Using a Faster Injection Rate, Late Arterial Phase, and Weight-Based Contrast Dosing.
[So] Source:Can Assoc Radiol J;68(4):371-378, 2017 Nov.
[Is] ISSN:1488-2361
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study aimed to update our liver computed tomography (CT) protocol according to published guidelines, and to quantitatively evaluate the effect of these modifications. METHODS: The modified liver CT protocol employed a faster injection rate (5 vs 3 mL/s), later arterial phase (20-second vs 10-second postbolus trigger), and weight-based dosing of iodinated contrast (1.7 mL/kg vs 100 mL fixed dose). Liver and vascular attenuation values were measured on CTs of patients with cirrhosis from January to September 2015 (old protocol, n = 49) and from October to December 2015 (modified protocol, n = 31). CTs were considered adequate if liver enhancement exceeded 50 Hounsfield units (HU) in portal venous phase, or when the unenhanced phase was unavailable, if a minimum iodine concentration of 500 mg I/kg was achieved. Attenuations and iodine concentrations were compared using the t test and the number of suboptimal studies was compared with Fisher's exact test. RESULTS: CTs acquired with the modified protocol demonstrated higher aortic (P = .001) and portal vein (P < .0001) attenuations in the arterial phase as well as greater hepatic attenuation on all postcontrast phases (P = .0006, .002, and .003 for arterial, venous, and equilibrium phases, respectively). Hepatic enhancement in the portal venous phase (61 ± 15 HU vs 51 ± 16 HU; P = .0282) and iodine concentrations (595 ± 88 mg I/kg vs 456 ± 112 mg I/kg; P < .0001) were improved, and the number of suboptimal studies was reduced from 57% to 23% (P = .01). CONCLUSIONS: A liver CT protocol with later arterial phase, faster injection rate, and weight-based dosing of intravenous contrast significantly improves liver enhancement and iodine concentrations in patients with cirrhosis, resulting in significantly fewer suboptimal studies.
[Mh] Termos MeSH primário: Peso Corporal
Meios de Contraste/administração & dosagem
Iopamidol/administração & dosagem
Cirrose Hepática/diagnóstico por imagem
Intensificação de Imagem Radiográfica/métodos
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Relação Dose-Resposta a Droga
Feminino
Fidelidade a Diretrizes
Seres Humanos
Fígado/diagnóstico por imagem
Masculino
Meia-Idade
Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE


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[PMID]:28618281
[Au] Autor:Tian FX; Xu B; Lin YL; Hu CY; Zhang TY; Xia SJ; Chu WH; Gao NY
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, Institute of Disinfection By-product Control in Water Treatment, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.
[Ti] Título:Chlor(am)ination of iopamidol: Kinetics, pathways and disinfection by-products formation.
[So] Source:Chemosphere;184:489-497, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The degradation kinetics, pathways and disinfection by-products (DBPs) formation of iopamidol by chlorine and chloramines were investigated in this paper. The chlorination kinetics can be well described by a second-order model. The apparent second-order rate constants of iopamidol chlorination significantly increased with solution pH. The rate constants of iopamidol with HOCl and OCl were calculated as (1.66 ± 0.09) × 10 M s and (0.45± 0.02) M s , respectively. However, the chloramination of iopamidol fitted well with third-order kinetics and the maximum of the apparent rate constant occurred at pH 7. It was inferred that the free chlorine (i.e., HOCl and OCl ) can react with iopamidol while the combined chlorine species (i.e., NH Cl and NHCl ) were not reactive with iopamidol. The main intermediates during chlorination or chloramination of iopamidol were identified using ultra performance liquid chromatography - electrospray ionization-mass spectrometry (UPLC-ESI-MS), and the destruction pathways including stepwise deiodination, hydroxylation as well as chlorination were then proposed. The regular and iodinated DBPs formed during chlorination and chloramination of iopamidol were measured. It was found that iodine conversion from iopamidol to toxic iodinated DBPs distinctly increased during chloramination. The results also indicated that although chloramines were much less reactive than chlorine toward iopamidol, they led to the formation of much more toxic iodinated DBPs, especially CHI .
[Mh] Termos MeSH primário: Cloraminas/química
Desinfetantes/toxicidade
Desinfecção/métodos
Halogenação
Iopamidol/química
[Mh] Termos MeSH secundário: Desinfetantes/química
Iopamidol/toxicidade
Cinética
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/toxicidade
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chloramines); 0 (Disinfectants); 0 (Water Pollutants, Chemical); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE


  5 / 2627 MEDLINE  
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[PMID]:28601007
[Au] Autor:Xu Z; Li X; Hu X; Yin D
[Ad] Endereço:Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, China.
[Ti] Título:Distribution and relevance of iodinated X-ray contrast media and iodinated trihalomethanes in an aquatic environment.
[So] Source:Chemosphere;184:253-260, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Distribution and relevance of iodinated X-ray contrast media (ICM) and iodinated disinfection byproducts (I-DBPs) in a real aquatic environment have been rarely documented. In this paper, some ICM were proven to be strongly correlated with I-DBPs through investigation of five ICM and five iodinated trihalomethanes (I-THMs) in surface water and two drinking water treatment plants (DWTPs) of the Yangtze River Delta, China. The total ICM concentrations in Taihu Lake and the Huangpu River ranged from 88.7 to 131 ng L and 102-252 ng L , respectively. While the total I-THM concentrations ranged from 128 to 967 ng L in Taihu Lake and 267-680 ng L in the Huangpu River. Iohexol, the dominant ICM, showed significant positive correlation (p < 0.01) with CHClI in Taihu Lake. Iopamidol and iomeprol correlated positively (p < 0.01) with some I-THMs in the Huangpu River. The observed pronounced correlations between ICM and I-THMs indicated that ICM play an important role in the formation of I-THMs in a real aquatic environment. Characteristics of the I-THM species distributions indicated that I-THMs may be transformed by natural conditions. Both DWTPs showed negligible removal efficiencies for total ICM (<20%). Strikingly high concentrations of total I-THMs were observed in the finished water (2848 ng L in conventional DWTP and 356 ng L in advanced DWTP). Obvious transformation of ICM to I-THMs was observed during the chlorination and ozonization processes in DWTPs. We suggest that ICM is an important source for I-DBP formation in the real aquatic environment.
[Mh] Termos MeSH primário: Meios de Contraste/análise
Monitoramento Ambiental
Trialometanos/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: China
Desinfecção
Halogenação
Iodetos
Iodo
Iohexol
Iopamidol/análogos & derivados
Ozônio
Rios
Água
Purificação da Água
Abastecimento de Água
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Iodides); 0 (Trihalomethanes); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 17E17JBP8L (iomeprol); 4419T9MX03 (Iohexol); 66H7ZZK23N (Ozone); 9679TC07X4 (Iodine); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE


  6 / 2627 MEDLINE  
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[PMID]:28534069
[Au] Autor:Honda Y; Goto K; Nakamura Y; Terada H; Sentani K; Yasui W; Sekino Y; Hayashi T; Teishima J; Matsubara A; Fuji T; Kaichi Y; Higaki T; Baba Y; Iida M; Awai K
[Ad] Endereço:Department of Diagnostic Radiology, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 7340037, Japan. honday@hiroshima-u.ac.jp.
[Ti] Título:Imaging features of papillary renal cell carcinoma with cystic change-dominant appearance in the era of the 2016 WHO classification.
[So] Source:Abdom Radiol (NY);42(7):1850-1856, 2017 Jul.
[Is] ISSN:2366-0058
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Papillary renal cell carcinoma (P-RCC) typically exhibits a homogeneous, solid hypovascular mass; P-RCC with a cystic appearance is atypical. Tubulocystic RCC (TC-RCC), a newly proposed entity for renal tumors in the 2016 WHO classification, and cystic papillary RCC, may yield similar imaging findings. Therefore, we investigated the incidence of papillary RCC with cystic changes and compared its CT and pathologic features to differentiate between two entities. METHODS: We retrospectively evaluated 26 consecutive patients diagnosed with P-RCC. Two radiologists consensually identified dominant masses indicative of cystic changes on CT scans and recorded their Bosniak classification. In addition, two pathologists inspected the whole area of tumors macroscopically, labeled them as solid- or cystic change-dominant tumors, determined the pathogenesis of the cystic components (necrosis or hemorrhage), and recorded their inherent cystic characteristics (with/without TC-RCC components). We defined masses with cystic changes involving more than 50% of the entire tumor as cystic change-dominant tumors. RESULTS: Of the 26 tumors, 7 (27%) were diagnosed cystic change-dominant based on imaging and pathologic findings, of these, 2 were classified as Bosniak type III and 5 as Bosniak type IV. The pathologists confirmed that two type IV tumors demonstrated extensive necrosis and one type IV tumor revealed extensive hemorrhage. Four P-RCCs (type III and IV, 2 each) were of a mixed type harboring both solid and cystic components. Only one tumor exhibited a multilocular cystic appearance. All 7 cystic change-dominant P-RCCs were pathologically diagnosed as a pure P-RCC without TC-RCC components. CONCLUSION: While P-RCCs may contain cystic features, the multilocular type of cystic P-RCC is rare.
[Mh] Termos MeSH primário: Carcinoma Papilar/diagnóstico por imagem
Carcinoma Papilar/patologia
Carcinoma de Células Renais/diagnóstico por imagem
Carcinoma de Células Renais/patologia
Doenças Renais Císticas/diagnóstico por imagem
Doenças Renais Císticas/patologia
Neoplasias Renais/diagnóstico por imagem
Neoplasias Renais/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Meios de Contraste
Diagnóstico Diferencial
Feminino
Seres Humanos
Iopamidol
Masculino
Meia-Idade
Estadiamento de Neoplasias
Estudos Retrospectivos
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1007/s00261-017-1189-1


  7 / 2627 MEDLINE  
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[PMID]:28511589
[Au] Autor:Gill AB; Hilliard NJ; Hilliard ST; Graves MJ; Lomas DJ; Shaw A
[Ad] Endereço:1 Department of Radiology, University of Cambridge, Cambridge, UK.
[Ti] Título:A semi-automatic method for the extraction of the portal venous input function in quantitative dynamic contrast-enhanced CT of the liver.
[So] Source:Br J Radiol;90(1075):20160875, 2017 Jul.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To aid the extraction of the portal venous input function (PVIF) from axial dynamic contrast-enhanced CT images of the liver, eliminating the need for full manual outlining of the vessel across time points. METHODS: A cohort of 20 patients undergoing perfusion CT imaging of the liver was examined. Dynamic images of the liver were reformatted into contiguous thin slices. A region of interest was defined within a transverse section of the portal vein on a single contrast-enhanced image. This region of interest was then computationally projected across all thin slices for all time points to yield a semi-automated PVIF curve. This was compared against the "gold-standard" PVIF curve obtained by conventional manual outlining. RESULTS: Bland-Altman plots of curve characteristics indicated no substantial difference between automated and manual PVIF curves [concordance correlation coefficient in the range (0.66, 0.98)]. No substantial differences were shown by Bland-Altman plots of derived pharmacokinetic parameters when a suitable kinetic model was applied in each case [concordance correlation coefficient in range (0.92, 0.95)]. CONCLUSION: This semi-automated method of extracting the PVIF performed equivalently to a "gold-standard" manual method for assessing liver function. Advances in knowledge: This technique provides a quick, simple and effective solution to the problems incurred by respiration motion and partial volume factors in the determination of the PVIF in liver dynamic contrast-enhanced CT.
[Mh] Termos MeSH primário: Hepatopatias/diagnóstico por imagem
Fígado/irrigação sanguínea
Fígado/diagnóstico por imagem
Veia Porta/diagnóstico por imagem
Interpretação de Imagem Radiográfica Assistida por Computador/métodos
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Algoritmos
Meios de Contraste/farmacocinética
Seres Humanos
Iohexol/farmacocinética
Iopamidol/farmacocinética
Movimento (Física)
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 4419T9MX03 (Iohexol); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20160875


  8 / 2627 MEDLINE  
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[PMID]:28471868
[Au] Autor:Kidoh M; Nakaura T; Funama Y; Shimonobo T; Shirasaka T; Hatemura M; Utsunomiya D; Oda S; Yuki H; Namimoto T; Higaki T; Awai K; Yamashita Y
[Ad] Endereço:From the Departments of *Diagnostic Radiology and †Medical Physics, Kumamoto University, Kumamoto; and ‡Department of Diagnostic Radiology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
[Ti] Título:Paradoxical Effect of Cardiac Output on Arterial Enhancement at Computed Tomography: Does Cardiac Output Reduction Simply Result in an Increase in Aortic Peak Enhancement?
[So] Source:J Comput Assist Tomogr;41(3):349-353, 2017 May/Jun.
[Is] ISSN:1532-3145
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate the effect of cardiac output (CO) on aortic peak enhancement using protocols with different contrast material (CM) injection durations. METHODS: We used a flow phantom that simulated the human circulatory system. Contrast material was injected at a rate of 4.0 mL/s for a period of 2.5, 5, 10, 15, or 20 seconds for a CO of 2.8, 4.2, and 5.6 L/min. Single-level serial computed tomography scans of the simulated aorta were acquired after the start of CM delivery, and aortic peak enhancement was recorded under the different injection protocols. RESULTS: Under a long injection duration protocol (20 seconds), a decrease in CO increased aortic peak enhancement proportionally (CO of 2.8 L/min, 420 Hounsfield units [HU]; CO of 4.2 L/min, 365 HU; CO of 5.6 L/min, 291 HU). However, this effect was decreased under shorter injection duration protocols (5, 10, and 15 seconds); under the shortest (2.5-second) injection duration protocol, a decrease in CO resulted in a decrease in aortic peak enhancement (CO of 2.8 L/min, 36 HU; CO of 4.2 L/min, 51 HU; CO of 5.6 L/min, 55 HU). CONCLUSIONS: The magnitude of the effect of CO on aortic peak enhancement depends on the CM injection duration.
[Mh] Termos MeSH primário: Débito Cardíaco/fisiologia
Meios de Contraste/administração & dosagem
Iopamidol/administração & dosagem
Intensificação de Imagem Radiográfica/métodos
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Aorta/fisiologia
Imagens de Fantasmas
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/RCT.0000000000000541


  9 / 2627 MEDLINE  
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[PMID]:28445908
[Au] Autor:Petritsch B; Kosmala A; Gassenmaier T; Weng AM; Veldhoen S; Kunz AS; Bley TA
[Ti] Título:Diagnosis of Pulmonary Artery Embolism: Comparison of Single-Source CT and 3rd Generation Dual-Source CT using a Dual-Energy Protocol Regarding Image Quality and Radiation Dose.
[Ti] Título:Diagnostik der akuten Lungenarterienembolie: Vergleich von Single-Source CT und Dritt-Generation Dual-Source CT unter Einsatz eines Dual-Energy Protokolls ­ Bildqualität und Strahlenexposition..
[So] Source:Rofo;189(6):527-536, 2017 Jun.
[Is] ISSN:1438-9010
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:To compare radiation dose, subjective and objective image quality of 3 rd generation dual-source CT (DSCT) and dual-energy CT (DECT) with conventional 64-slice single-source CT (SSCT) for pulmonary CTA. 180 pulmonary CTA studies were performed in three patient cohorts of 60 patients each. Group 1: conventional SSCT 120 kV (ref.); group 2: single-energy DSCT 100 kV (ref.); group 3: DECT 90/Sn150 kV. CTDIvol, DLP, effective radiation dose were reported, and CT attenuation (HU) was measured on three central and peripheral levels. The signal-to-noise-ratio (SNR) and contrast-to-noise-ratio (CNR) were calculated. Two readers assessed subjective image quality according to a five-point scale. Mean CTDIvol and DLP were significantly lower in the dual-energy group compared to the SSCT group (p < 0.001 [CTDIvol]; p < 0.001 [DLP]) and the DSCT group (p = 0.003 [CTDIvol]; p = 0.003 [DLP]), respectively. The effective dose in the DECT group was 2.79 ±â€Š0.95 mSv and significantly smaller than in the SSCT group (4.60 ±â€Š1.68 mSv, p < 0.001) and the DSCT group (4.24 ±â€Š2.69 mSv, p = 0.003). The SNR and CNR were significantly higher in the DSCT group (p < 0.001). Subjective image quality did not differ significantly among the three protocols and was rated good to excellent in 75 % (135/180) of cases with an inter-observer agreement of 80 %. Dual-energy pulmonary CTA protocols of 3 rd generation dual-source scanners allow for significant reduction of radiation dose while providing excellent image quality and potential additional information by means of perfusion maps. · Dual-energy CT with 90/Sn150 kV configuration allows for significant dose reduction in pulmonary CTA.. · Subjective image quality was similar among the three evaluated CT-protocols (64-slice SSCT, single-energy DSCT, 90/Sn150 kV DECT) and was rated good to excellent in 75% of cases.. · Dual-energy CT provides potential additional information by means of iodine distribution maps.. · Petritsch B, Kosmala A, Gassenmaier T et al. Diagnosis of Pulmonary Artery Embolism: Comparison of Single-Source CT and 3rd Generation Dual-Source CT using a Dual-Energy Protocol Regarding Image Quality and Radiation Dose. Fortschr Röntgenstr 2017; 189: 527 - 536.
[Mh] Termos MeSH primário: Aumento da Imagem/instrumentação
Aumento da Imagem/métodos
Interpretação de Imagem Assistida por Computador/instrumentação
Interpretação de Imagem Assistida por Computador/métodos
Angiografia por Ressonância Magnética/instrumentação
Angiografia por Ressonância Magnética/métodos
Artéria Pulmonar/diagnóstico por imagem
Embolia Pulmonar/diagnóstico por imagem
Embolia Pulmonar/cirurgia
Imagem Radiográfica a Partir de Emissão de Duplo Fóton/instrumentação
Imagem Radiográfica a Partir de Emissão de Duplo Fóton/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Artefatos
Meios de Contraste
Desenho de Equipamento
Feminino
Seres Humanos
Iopamidol/análogos & derivados
Masculino
Meia-Idade
Variações Dependentes do Observador
Dose de Radiação
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 17E17JBP8L (iomeprol); JR13W81H44 (Iopamidol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-103089


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[PMID]:28402131
[Au] Autor:Mosconi C; Vicennati V; Papadopoulos D; Dalmazi GD; Morselli-Labate AM; Golfieri R; Pasquali R
[Ad] Endereço:1 Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi Hospital, Via Albertoni 15, 40138 Bologna, Italy.
[Ti] Título:Can Imaging Predict Subclinical Cortisol Secretion in Patients With Adrenal Adenomas? A CT Predictive Score.
[So] Source:AJR Am J Roentgenol;209(1):122-129, 2017 Jul.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study is to determine whether any correlation between CT findings and functional parameters exists to predict subclinical glucocorticoid secretion. MATERIALS AND METHODS: This is a retrospective database study of 55 patients with incidentally discovered adenomas, investigated through CT with an adrenal protocol, assessing diameters and attenuation values on the unenhanced and contrast-enhanced phases. Patients underwent blood cortisol and corticotropin evaluation and overnight dexamethasone suppression test (DST), in accordance with clinical recommendations. Cortisol levels higher than 50 nmol/L after DST identified subclinical cortisol secretion. We identified 28 subjects with lipid-rich nonsecreting adenomas, nine with lipid-rich secreting adenomas, 11 with lipid-poor nonsecreting adenomas, and seven with lipid-poor secreting adenoma. RESULTS: Cortisol levels after DST were significantly and positively related to mass diameters. At univariate analysis, maximum and minimum diameters and attenuation in the delayed phase were significantly related to the presence of secreting or nonsecreting adenoma; at multivariate analysis, only the minimum diameter and the attenuation in the venous phase entered the stepwise logistic regression. Similarly, minimum diameter and attenuation in the venous phase emerged also at the multivariate stepwise regression between radiologic parameters and cortisol levels after DST. The formula of the radiologic score computed by using the coefficients of the multivariate regression was as follows: (0.1914 × minimum diameter) + (0.0308 × enhanced attenuation). The diagnostic accuracy of this discriminatory score in differentiating secreting from nonsecreting adenomas was 84.9%, the sensitivity was 81.3%, and the specificity was 87.2%. Adenomas with scores greater than 7.59 were considered as secreting adenomas, and adenomas with scores less than 7.36 were considered as nonsecreting adenomas. CONCLUSION: This study shows that imaging parameters can predict subclinical cortisol hypersecretion in patients with adrenal adenomas.
[Mh] Termos MeSH primário: Adenoma Adrenocortical/diagnóstico por imagem
Adenoma Adrenocortical/patologia
Hidrocortisona/secreção
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/secreção
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Meios de Contraste
Feminino
Seres Humanos
Achados Incidentais
Iopamidol/análogos & derivados
Masculino
Meia-Idade
Valor Preditivo dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Contrast Media); 17E17JBP8L (iomeprol); 9002-60-2 (Adrenocorticotropic Hormone); JR13W81H44 (Iopamidol); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.16965



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