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[PMID]: 28135331 [Au] Autor: Karhula SS; Finnilä MA; Lammi MJ; Ylärinne JH; Kauppinen S; Rieppo L; Pritzker KP; Nieminen HJ; Saarakkala S [Ad] Endereço: Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland. [Ti] Título: Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography. [So] Source: PLoS One;12(1):e0171075, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Contrast-enhanced micro-computed tomography (CEµCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular cartilage. However, the selectivity of the PTA staining to articular cartilage constituents remains to be elucidated. The aim of this study was to investigate the dependence of PTA for the collagen content in bovine articular cartilage. Adjacent bovine articular cartilage samples were treated with chondroitinase ABC and collagenase to degrade the proteoglycan and the collagen constituents in articular cartilage, respectively. Enzymatically degraded samples were compared to the untreated samples using CEµCT and reference methods, such as Fourier-transform infrared imaging. Decrease in the X-ray attenuation of PTA in articular cartilage and collagen content was observed in cartilage depth of 0-13% and deeper in tissue after collagen degradation. Increase in the X-ray attenuation of PTA was observed in the cartilage depth of 13-39% after proteoglycan degradation. The X-ray attenuation of PTA-labelled articular cartilage in CEµCT is associated mainly with collagen content but the proteoglycans have a minor effect on the X-ray attenuation of the PTA-labelled articular cartilage. In conclusion, the PTA labeling provides a feasible CEµCT method for 3D characterization of articular cartilage. [Mh] Termos MeSH primário: Cartilagem Articular/diagnóstico por imagem Cartilagem Articular/metabolismo Ácido Fosfotúngstico/química Microtomografia por Raio-X/métodos [Mh] Termos MeSH secundário: Animais Bovinos Condroitina ABC Liase/metabolismo Colagenases/metabolismo Eletroforese em Gel de Ágar Ácido Ioxáglico/química Proteoglicanas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Proteoglycans); 12067-99-1 (Phosphotungstic Acid); EC 3.4.24.- (Collagenases); EC 4.2.2.20 (Chondroitin ABC Lyase); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170922 [Lr] Data última revisão: 170922 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170131 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0171075

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[PMID]: 27588734 [Au] Autor: Bertin H; Bonnet R; Delemazure AS; Mourrain-Langlois E; Mercier J; Corre P [Ad] Endereço: 1 Clinique de Chirurgie Maxillo-Faciale et Stomatologie, CHU de Nantes, Nantes, France. [Ti] Título: Three-dimensional cone-beam CT sialography in non tumour salivary pathologies: procedure and results. [So] Source: Dentomaxillofac Radiol;46(1):20150431, 2017 Jan. [Is] ISSN: 0250-832X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Non-tumour salivary diseases are common. Imaging studies are essential for their diagnosis and before undergoing an endoscopic or surgical treatment. In this study, we aimed at presenting our procedure and results obtained with three-dimensional CBCT (3D-CBCT) sialography for non-tumour salivary gland diseases. METHODS: Patients with parotid or submandibular salivary symptoms were examined by 3D-CBCT sialography. They received an intraductal injection of 0.5 mL of water-soluble contrast medium maintained in the gland, followed by examination in a NewTom wide-field CBCT device. Images were processed with multiplanar and 3D reconstructions. RESULTS: A ductal exploration could be performed until the fourth divisions. The main lesions found were stones, stenosis, dilatations and "dead tree" appearance of the ductal system. No side effects of the catheterization or the iodine contrast were reported, nor tissue damages related to the contrast keeping technique. CONCLUSIONS: 3D-CBCT sialography seems to represent a reliable non-invasive diagnostic tool for ductal salivary diseases. More studies are needed to assess the value of 3D-CBCT sialography compared with conventional imaging. [Mh] Termos MeSH primário: Tomografia Computadorizada de Feixe Cônico/métodos Imagem Tridimensional/métodos Doenças das Glândulas Salivares/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Meios de Contraste Feminino Seres Humanos Ácido Ioxáglico Masculino [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170924 [Lr] Data última revisão: 170924 [Sb] Subgrupo de revista: D [Da] Data de entrada para processamento: 160903 [St] Status: MEDLINE

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[PMID]: 27415967 [Au] Autor: Newton MD; Hartner SE; Timmons S; Delaney ND; Pirrone MG; Baker KC; Maerz T [Ad] Endereço: Orthopaedic Research Laboratory, Beaumont Health, 3811W Thirteen Mile Road, Royal Oak, Michigan, 48073. [Ti] Título: Contrast-enhanced µCT of the intervertebral disc: A comparison of anionic and cationic contrast agents for biochemical and morphological characterization. [So] Source: J Orthop Res;35(5):1067-1075, 2017 May. [Is] ISSN: 1554-527X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The objective of this study was to quantify and compare the contrast-enhancing properties of the anionic contrast agent ioxaglate/Hexabrix, and cationic contrast agent CA for biochemical and morphological characterization of the intervertebral disc (IVD) via µCT. Optimal contrast agent concentrations were determined by incubating rat lumbar IVDs in dilutions of Hexabrix-320 (20%, 30%, 40%, and 50%) and CA (10, 20, 30, and 40 mg I/ml). µCT imaging was performed at 70 kVp, 114 µA, and 250 ms integration time, 12 µm voxel size. The kinetics of contrast enhancement were quantified with cumulative incubations for 0.5, 1, 2, 12, 16, 20, and 24 h using both agents. Agreement in morphological quantification was assessed via serial scans of the same IVDs. Correlation of attenuation to glycosaminoglycan (GAG) content was determined by enzymatic digestion of IVDs, subsequent µCT imaging, and GAG quantification via dimethylmethylene blue assay. Forty percent Hexabrix and 30 mg I/ml CA were chosen as optimal concentrations. Hexabrix enabled greater delineation of the IVD from surrounding tissues, and CA had the lowest uptake in surrounding soft tissue. Twenty-four hour incubation was sufficient for >99% equilibration of both agents. A high level of agreement was observed in the quantification of IVD volume (ICC = 0.951, r = 0.997) and height (ICC = 0.947, r = 0.991). Both agents exhibited strong linear correlations between µCT attenuation and GAG content (Hexabrix: r = -0.940; CA : r = 0.887). Both agents enable biochemical and morphological quantification of the IVD via contrast-enhanced µCT and are effective tools for preclinical characterization. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1067-1075, 2017. [Mh] Termos MeSH primário: Meios de Contraste Etilenodiaminas Disco Intervertebral/diagnóstico por imagem Iodobenzenos Ácido Ioxáglico Microtomografia por Raio-X [Mh] Termos MeSH secundário: Animais Feminino Ratos Endogâmicos Lew [Pt] Tipo de publicação: COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); 0 (Ethylenediamines); 0 (Iodobenzenes); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160715 [St] Status: MEDLINE [do] DOI: 10.1002/jor.23364

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[PMID]: 27302693 [Au] Autor: Oh DJ; Lakin BA; Stewart RC; Wiewiorski M; Freedman JD; Grinstaff MW; Snyder BD [Ad] Endereço: Harvard-MIT Health Sciences and Technology Program, Harvard Medical School, Cambridge, Massachusetts. [Ti] Título: Contrast-enhanced CT imaging as a non-destructive tool for ex vivo examination of the biochemical content and structure of the human meniscus. [So] Source: J Orthop Res;35(5):1018-1028, 2017 May. [Is] ISSN: 1554-527X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The biochemical and histopathological techniques used to investigate meniscal content and structure are destructive and time-consuming. Therefore, this study evaluated whether contrast-enhanced computed tomography (CECT) attenuation and contrast agent flux using the iodinated contrast agents CA4+ and ioxaglate correlate with the glycosaminoglycan (GAG) content/distribution and water content in human menisci. The optimal ioxaglate and CA4+ contrast agent concentrations for mapping meniscal GAG distribution were qualitatively determined by comparison of CECT color maps with Safranin-O stained histological sections. The associations between CECT attenuation and GAG content, CECT attenuation and water content, and flux and water content at various time points were determined using both contrast agents. Depth-wise analyses were also performed through each of the native surfaces to examine differences in contrast agent diffusion kinetics and equilibrium partitioning. The optimal concentrations for GAG depiction for ioxaglate and CA4+ were ≥80 and 12 mgI/ml, respectively. Using these concentrations, weak to moderate associations were found between ioxaglate attenuation and GAG content at all diffusion time points (1-48 h), while strong and significant associations were observed between CA4+ attenuation and GAG content as early as 7 h (R ≥ 0.67), being strongest at the equilibrium time point (48 h, R = 0.81). CECT attenuation for both agents did not significantly correlate with water content, but CA4+ flux correlated with water content (R = 0.56-0.64). CECT is a promising, non-destructive imaging technique for ex vivo assessment of meniscal GAG concentration and water content compared to traditional biochemical and histopathological methods. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1018-1028, 2017. [Mh] Termos MeSH primário: Ácido Ioxáglico Meniscos Tibiais/diagnóstico por imagem Tomografia Computadorizada por Raios X [Mh] Termos MeSH secundário: Adulto Etilenodiaminas Feminino Glicosaminoglicanos/análise Seres Humanos Iodobenzenos Masculino Meia-Idade Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ethylenediamines); 0 (Glycosaminoglycans); 0 (Iodobenzenes); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160616 [St] Status: MEDLINE [do] DOI: 10.1002/jor.23337

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[PMID]: 28128751 [Au] Autor: Gerk U; Mrowietz C; Sternitzky R; Franke RP; Spitzer SG; Jung F [Ad] Endereço: Krankenhaus Dresden-Friedrichstadt, II. Medizinische Klinik, Dresden, Germany. [Ti] Título: Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study. [So] Source: Clin Hemorheol Microcirc;64(3):297-304, 2016. [Is] ISSN: 1875-8622 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography.The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line.VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%. [Mh] Termos MeSH primário: Doença da Artéria Coronariana/tratamento farmacológico Ácido Ioxáglico/uso terapêutico Microcirculação/efeitos dos fármacos [Mh] Termos MeSH secundário: Idoso Doença da Artéria Coronariana/sangue Método Duplo-Cego Feminino Seres Humanos Ácido Ioxáglico/administração & dosagem Masculino Meia-Idade Estudos Prospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170128 [St] Status: MEDLINE [do] DOI: 10.3233/CH-168101

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[PMID]: 27865075 [Au] Autor: Seto AH; Kern MJ [Ad] Endereço: Division of Cardiology, Department of Medicine, Veterans Affairs Long Beach Medical Center, University of California, Irvine Medical Center, Orange, California. [Ti] Título: Does the AToMIC trial explode concerns of contrast coagulopathy? [So] Source: Catheter Cardiovasc Interv;88(5):738-739, 2016 Nov. [Is] ISSN: 1522-726X [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Angiografia Coronária/métodos Doença da Artéria Coronariana/diagnóstico Fibrinólise/fisiologia Ácido Ioxáglico/farmacologia Intervenção Coronária Percutânea/métodos Trombose/sangue Ácidos Tri-Iodobenzoicos/farmacologia [Mh] Termos MeSH secundário: Biomarcadores/sangue Meios de Contraste/farmacologia Doença da Artéria Coronariana/cirurgia Seres Humanos Trombose/diagnóstico Trombose/etiologia [Pt] Tipo de publicação: EDITORIAL [Nm] Nome de substância: 0 (Biomarkers); 0 (Contrast Media); 0 (Triiodobenzoic Acids); HW8W27HTXX (iodixanol); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161120 [St] Status: MEDLINE [do] DOI: 10.1002/ccd.26827

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[PMID]: 27033729 [Au] Autor: Arbabi V; Pouran B; Weinans H; Zadpoor AA [Ad] Endereço: Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, 2628CD Delft, The Netherlands. Electronic address: v.arbabi@gmail.com. [Ti] Título: Multiphasic modeling of charged solute transport across articular cartilage: Application of multi-zone finite-bath model. [So] Source: J Biomech;49(9):1510-1517, 2016 Jun 14. [Is] ISSN: 1873-2380 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Charged and uncharged solutes penetrate through cartilage to maintain the metabolic function of chondrocytes and to possibly restore or further breakdown the cartilage tissue in different stages of osteoarthritis. In this study the transport of charged solutes across the various zones of cartilage was quantified, taken into account the physicochemical interactions between the solute and the cartilage constituents. A multiphasic finite-bath finite element (FE) model was developed to simulate equine cartilage diffusion experiments that used a negatively charged contrast agent (ioxaglate) in combination with serial micro-computed tomography (micro-CT) to measure the diffusion. By comparing the FE model with the experimental data both the diffusion coefficient of ioxaglate and the fixed charge density (FCD) were obtained. In the multiphasic model, cartilage was divided into multiple (three) zones to help understand how diffusion coefficient and FCD vary across cartilage thickness. The direct effects of charged solute-FCD interaction on diffusion were investigated by comparing the diffusion coefficients derived from the multiphasic and biphasic-solute models. We found a relationship between the FCD obtained by the multiphasic model and ioxaglate partitioning obtained from micro-CT experiments. Using our multi-zone multiphasic model, diffusion coefficient of the superficial zone was up to ten-fold higher than that of the middle zone, while the FCD of the middle zone was up to almost two-fold higher than that of the superficial zone. In conclusion, the developed finite-bath multiphasic model provides us with a non-destructive method by which we could obtain both diffusion coefficient and FCD of different cartilage zones. The outcomes of the current work will also help understand how charge of the bath affects the diffusion of a charged molecule and also predict the diffusion behavior of a charged solute across articular cartilage. [Mh] Termos MeSH primário: Cartilagem Articular/metabolismo Análise de Elementos Finitos [Mh] Termos MeSH secundário: Animais Transporte Biológico Cartilagem Articular/diagnóstico por imagem Condrócitos/metabolismo Meios de Contraste/química Difusão Cavalos Ácido Ioxáglico/metabolismo Modelos Biológicos Osteoartrite/metabolismo Microtomografia por Raio-X [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171024 [Lr] Data última revisão: 171024 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160402 [St] Status: MEDLINE

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[PMID]: 26773574 [Au] Autor: Shah B; Berger JS; Allen N; Guo Y; Sedlis SP; Xu J; Perez A; Attubato M; Slater J; Feit F [Ad] Endereço: Department of Medicine (Cardiology), NYU School of Medicine, New York, New York. [Ti] Título: The assessment of thrombotic markers utilizing ionic versus non-ionic contrast during coronary angiography and intervention trial. [So] Source: Catheter Cardiovasc Interv;88(5):727-737, 2016 Nov. [Is] ISSN: 1522-726X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To determine how two different types of iodinated contrast media (CM), low-osmolar ionic dimer ioxaglate (Hexabrix) and iso-osmolar non-ionic dimer iodixanol (Visipaque), affect multiple indices of hemostasis. BACKGROUND: In vitro models demonstrate differential effects of ionic and non-ionic CM on markers of hemostasis. METHODS: This blinded endpoint trial randomized 100 patients to ioxaglate or iodixanol. The primary endpoint was change in endogenous thrombin potential (ETP) following diagnostic angiography. Secondary endpoints included change in markers of fibrinolysis [tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1)] and platelet aggregation following diagnostic angiography and percutaneous coronary intervention (PCI) with bivalirudin. Data are presented as median [interquartile range]. RESULTS: ETP significantly decreased after diagnostic angiography in both ioxaglate (baseline 1810 nM*minute [1540-2089] to post-angiography 649 nM*minute [314-1347], p < 0.001) and iodixanol groups (baseline 1682 nM*minute [1534-2147] to post-angiography 681 nM*minute [229-1237], p < 0.001), but the decrease was not different between CM (p = 0.70). There was a significant increase in ETP during PCI (n = 45), despite the use of bivalirudin, suggesting a prothrombotic effect of PCI (post-angiography 764 nM*minute [286-1283] to post-PCI 1081 nM*minute [668-1552], p = 0.02). There were no significant differential effects on tPA, PAI-1, and markers of platelet activity. CONCLUSION: There were no significant differential effects between ioxaglate and iodixanol. Both CM led to significant reductions in thrombin generation and no significant effects on fibrinolytic activity or platelet activity, thereby contributing to a favorable antithrombotic milieu. © 2016 Wiley Periodicals, Inc. [Mh] Termos MeSH primário: Angiografia Coronária/métodos Doença da Artéria Coronariana/diagnóstico Fibrinólise/fisiologia Ácido Ioxáglico/farmacologia Intervenção Coronária Percutânea/métodos Trombose/sangue Ácidos Tri-Iodobenzoicos/farmacologia [Mh] Termos MeSH secundário: Idoso Biomarcadores/sangue Meios de Contraste/farmacologia Doença da Artéria Coronariana/cirurgia Feminino Seguimentos Seres Humanos Masculino Meia-Idade Estudos Prospectivos Método Simples-Cego Trombose/diagnóstico Trombose/etiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Biomarkers); 0 (Contrast Media); 0 (Triiodobenzoic Acids); HW8W27HTXX (iodixanol); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 171101 [Lr] Data última revisão: 171101 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160117 [St] Status: MEDLINE [do] DOI: 10.1002/ccd.26353

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[PMID]: 26481591 [Au] Autor: Giustino G; Baber U; Mastoris I; Vlachojannis GJ; Yu J; Teirstein PS; Downey WE; Batchelor WB; Casterella PJ; Nikolsky E; Wong SC; Theodoropoulos KN; Dangas GD; Mehran R [Ad] Endereço: Mount Sinai Medical Center, New York, New York. [Ti] Título: One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study. [So] Source: Catheter Cardiovasc Interv;87(4):703-9, 2016 Mar. [Is] ISSN: 1522-726X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Long-term clinical outcomes after exposure to non-ionic iso-osmolar contrast medium (IOCM) or ionic low-osmolar CM (LOCM) in patients with chronic kidney disease (CKD) undergoing coronary angiography are unclear. METHODS: The ICON trial was a prospective, double-blinded, multicentre study that randomly assigned 146 patients with CKD undergoing coronary angiography with or without percutaneous coronary intervention to the non-ionic IOCM Iodixanol or the ionic LOCM Ioxaglate. We report the 1-year clinical outcomes. RESULTS: After randomization, baseline and procedural characteristics were well-matched between the two groups. At 1 year, three deaths (4.1%) occurred in the ioxaglate and nine deaths in the iodixanol group (13.6%, P = 0.07). The cardiac death rate at 1 year was 2.7% in the ioxaglate group and 9.1% in the iodixanol group (P = 0.07). There were no significant differences in the rates of myocardial infarction (1.4% vs. 1.5%; P = 1.00) and repeated revascularization (6.8% vs. 9.1%; P = 0.75). CONCLUSIONS: The use of ionic LOCM ioxaglate was associated with a numerically lower mortality at 1 year as compared to iodixanol in patients who underwent cardiac catheterization. Future studies evaluating long-term safety following exposure to different types of CM are warranted. [Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente Angioplastia Coronária com Balão/efeitos adversos Meios de Contraste/efeitos adversos Angiografia Coronária/efeitos adversos Doença da Artéria Coronariana/diagnóstico por imagem Doença da Artéria Coronariana/terapia Ácido Ioxáglico/efeitos adversos Falência Renal Crônica/complicações Ácidos Tri-Iodobenzoicos/efeitos adversos [Mh] Termos MeSH secundário: Lesão Renal Aguda/diagnóstico Lesão Renal Aguda/mortalidade Idoso Idoso de 80 Anos ou mais Angioplastia Coronária com Balão/mortalidade Angiografia Coronária/mortalidade Doença da Artéria Coronariana/mortalidade Progressão da Doença Método Duplo-Cego Feminino Seres Humanos Ácido Ioxáglico/análogos & derivados Falência Renal Crônica/diagnóstico Falência Renal Crônica/mortalidade Masculino Meia-Idade Infarto do Miocárdio/etiologia Infarto do Miocárdio/mortalidade Valor Preditivo dos Testes Estudos Prospectivos Fatores de Risco Fatores de Tempo Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Contrast Media); 0 (Triiodobenzoic Acids); HW8W27HTXX (iodixanol); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151021 [St] Status: MEDLINE [do] DOI: 10.1002/ccd.26106

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[PMID]: 26378414 [Au] Autor: Christakopoulos GE; Kotsia AP; Christopoulos G; Abdullah SM; Rangan BV; Roesle M; Banerjee S; Brilakis ES [Ti] Título: Comparison of Iodixanol and Ioxaglate for Coronary Optical Coherence Tomography Imaging. [So] Source: J Invasive Cardiol;27(12):E287-90, 2015 Dec. [Is] ISSN: 1557-2501 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: The impact of contrast type on coronary imaging using optical coherence tomography (OCT) has received limited study. We compared OCT imaging obtained using the non-ionic, iso-osmolar iodixanol with the ionic, low-osmolar ioxaglate. METHODS: Twenty-two vessels in 20 patients were imaged twice using manual injection of iodixanol and ioxaglate in random order. OCT images were analyzed at 1 mm intervals to determine lumen area, artifact diameter and area, as well as stent strut coverage and malapposition in OCT pullbacks that included stents. RESULTS: There were no complications related to OCT imaging or to contrast administration. A total of 2184 cross-sections (1092 with iodixanol and 1092 with ioxaglate) were analyzed. Compared with iodixanol, imaging using ioxaglate provided similar mean lumen area (6.21 ± 2.83 mm2 vs 6.27 ± 2.83 mm2; Spearman's rho, 0.982), mean minimum lumen diameter (2.47 ± 0.59 mm vs 2.50 ± 0.58 mm; Spearman's rho, 0.939), and mean maximum lumen diameter (2.99 ± 0.71 mm vs 3.01 ± 0.70 mm; Spearman's rho, 0.964), but lower mean artifact area per cross-section (0.099 ± 0.325 mm2 vs 0.068 ± 0.329 mm2; P<.001). Analyses of 3303 stent struts in 388 cross-sections (194 with iodixanol and 194 with ioxaglate) demonstrated similar strut malapposition rates (11.82% vs 13.90%; P=.10) and strut coverage (41.92% vs 40.33%; P=.35). CONCLUSIONS: Compared with iodixanol, OCT imaging using ioxaglate provided similar lumen and diameter measurements and stent strut characterization, but smaller area of artifact. [Mh] Termos MeSH primário: Meios de Contraste/farmacologia Doença da Artéria Coronariana/diagnóstico Vasos Coronários/diagnóstico por imagem Ácido Ioxáglico/farmacologia Tomografia de Coerência Óptica/métodos Ácidos Tri-Iodobenzoicos/farmacologia [Mh] Termos MeSH secundário: Idoso Angiografia Coronária Doença da Artéria Coronariana/cirurgia Vasos Coronários/cirurgia Stents Farmacológicos Seres Humanos Injeções Intra-Arteriais Masculino Revascularização Miocárdica [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Contrast Media); 0 (Triiodobenzoic Acids); HW8W27HTXX (iodixanol); Z40X7EI2AF (Ioxaglic Acid) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150918 [St] Status: MEDLINE

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