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[PMID]:20207421
[Au] Autor:Lee BH; Kim YK
[Ad] Endereço:Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, 516, Gojan Dong, Ansan City, Kyunggi Province, 425-707 Seoul, Republic of Korea.
[Ti] Título:BDNF mRNA expression of peripheral blood mononuclear cells was decreased in depressive patients who had or had not recently attempted suicide.
[So] Source:J Affect Disord;125(1-3):369-73, 2010 Sep.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recent reports have suggested a pathophysiological role for brain-derived neurotrophic factor (BDNF) in major depression and suicide. We evaluate BDNF mRNA in peripheral blood mononuclear cells (PBMCs) of patients with major depression who had or had not recently attempted suicide. METHODS: BDNF mRNA expression was examined in PBMCs of 30 major depressed patients without recent suicide attempts, 30 major depressed patients with recent suicide attempts, and 30 healthy controls. All patients were diagnosed with major depressive disorder (MDD) and they were either medication-naïve or medication-free. BDNF mRNA expression was measured using real-time quantitative PCR. RESULTS: BDNF mRNA expression was significantly decreased in PBMCs of MDD patients, with or without a history of suicide attempts, when compared with healthy controls (Z=-5.233, p<0.001). Suicidal MDD patients had more decrease in BDNF mRNA expression (chi(2)=45.881, df=2, p<0.001). LIMITATIONS: The sample size of the present study was relatively small. Although suicidal MDD patients had higher HDRS scores than non-suicidal patients, the comparison of BDNF mRNA between them could not be adjusted for HDRS score. CONCLUSIONS: Our study suggests that the BDNF mRNA expression is reduced in PBMCs of patients with major depression. This alteration of BDNF mRNA expression was noteworthy in recent suicide attempters. Such a decrease in BDNF mRNA might be associated with BDNF decrease in serum or plasma, and might also correspond to a BDNF decline in the brains of MDD patients.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/genética
Transtorno Depressivo Maior/genética
RNA Mensageiro/sangue
Tentativa de Suicídio/psicologia
[Mh] Termos MeSH secundário: Adulto
Transtorno Depressivo Maior/diagnóstico
Transtorno Depressivo Maior/psicologia
Feminino
Ficoll
Genótipo
Seres Humanos
Masculino
Ácido Metrizoico
Meia-Idade
Monócitos/metabolismo
Distribuição Normal
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (RNA, Messenger); 25702-74-3 (Ficoll); 66720-17-0 (lymphoprep); CM1N99QR1M (Metrizoic Acid)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100309
[St] Status:MEDLINE
[do] DOI:10.1016/j.jad.2010.01.074


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[PMID]:20005388
[Au] Autor:Song HJ; Xue WJ; Li Y; Tian XH; Song Y; Ding XM; Feng XS; Tian PX; Li ZL
[Ad] Endereço:Department of Renal Transplant, Center of Nephropathy, First Affiliated Hospital, Xi'an Jiaotong University Medical College, Xi'an, Shannxi, PR China.
[Ti] Título:Improved islet survival and funtion with rat endothelial cells in vitro co-culture.
[So] Source:Transplant Proc;41(10):4302-6, 2009 Dec.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To preserve its function, transplanted islets must be revascularized because arterial and venous connections are disrupted during islet isolation. The current paradigm is that islet revascularization originates from the transplant recipient. This study was designed to test whether the function of isolated islets can be retained by co-culture with thoracic aorta endothelial cells in vitro. METHODS: Sprague-Dawley rats were used in this study. The endothelial cells (ECs) were isolated from the thoracic aorta. The viability of the isolated islets was assessed by acridine orange/propidium iodide (AO/PI) double staining. The islets were either placed in standard cultures (group A) or in co-cultures with ECs (group B). Islet viablity was assessed by an insulin release assay. RESULTS: The islets in group B exhibited normal morphology with >90% staining positive as detected by AO/PI with 7 days. Insulin release assays showed a significantly higher simulation index (SI) in group B compared with group A (P < .05) except on the first day. CONCLUSION: This study suggested that co-cultrue of freshly isolated rat islets with ECs improves postculture survival and islet function in vitro.
[Mh] Termos MeSH primário: Células Endoteliais/citologia
Ilhotas Pancreáticas/citologia
Ilhotas Pancreáticas/fisiologia
[Mh] Termos MeSH secundário: Animais
Separação Celular/métodos
Separação Celular/normas
Sobrevivência Celular
Técnicas de Cocultura
Colagenases
Ficoll
Indicadores e Reagentes
Ácido Metrizoico
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indicators and Reagents); 25702-74-3 (Ficoll); 66720-17-0 (lymphoprep); CM1N99QR1M (Metrizoic Acid); EC 3.4.24.- (Collagenases)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091217
[St] Status:MEDLINE
[do] DOI:10.1016/j.transproceed.2009.09.071


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[PMID]:16632707
[Au] Autor:Lasser EC
[Ti] Título:Inadvertent injection of inappropriate contrast material.
[So] Source:AJR Am J Roentgenol;186(5):E9; author reply E9, 2006 May.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Meios de Contraste/efeitos adversos
Diatrizoato/efeitos adversos
Erros de Medicação
Metrizamida/efeitos adversos
Ácido Metrizoico/efeitos adversos
[Mh] Termos MeSH secundário: Meios de Contraste/administração & dosagem
Seres Humanos
Injeções
Mielografia
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Contrast Media); 117-96-4 (Diatrizoate); CM1N99QR1M (Metrizoic Acid); RHH3W8F1CO (Metrizamide)
[Em] Mês de entrada:0607
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:060425
[St] Status:MEDLINE


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[PMID]:12069387
[Au] Autor:Nagaeva O; Bondestam K; Olofsson J; Damber MG; Mincheva-Nilsson L
[Ad] Endereço:Department of Clinical Immunology, Umeå University, Sweden.
[Ti] Título:An optimized technique for separation of human decidual leukocytes for cellular and molecular analyses.
[So] Source:Am J Reprod Immunol;47(4):203-12, 2002 Apr.
[Is] ISSN:1046-7408
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:PROBLEM: Human decidua contains a significant number of leukocytes, phenotypically and functionally different from peripheral blood. In vitro studies of decidual leukocytes require constant improvement of cell isolation technique in order to obtain highly purified viable and functionally active cells. METHOD OF STUDY: Optimized isolation procedure of decidual leukocytes, based on non-enzymatic cell dispersion, Percoll gradient centrifugation and purification step involving immunomagnetic beads is compared with a similar procedure with Lymphoprep gradient. RESULTS: The method based on Percoll gradient gave a viable leukocyte fraction with higher amount of alphabetaT- and gammadeltaT cells compared with Lymphoprep gradient. The leukocytes exhibited a well-preserved ultrastructure and surface marker expression and were suitable for molecular analysis. The magnitude and the kinetics of their proliferative response were comparable with peripheral blood lymphocytes. CONCLUSIONS: The results provide an optimized method for isolation and enrichment of decidual leukocytes, suitable for phenotypic, ultrastructural, molecular and functional analyses.
[Mh] Termos MeSH primário: Separação Celular/métodos
Decídua/citologia
Decídua/imunologia
Leucócitos/citologia
Leucócitos/imunologia
[Mh] Termos MeSH secundário: Anticorpos Monoclonais
Complexo CD3/genética
Antígeno CD56/metabolismo
Centrifugação com Gradiente de Concentração
Feminino
Ficoll
Seres Humanos
Separação Imunomagnética
Imunofenotipagem
Técnicas In Vitro
Antígenos Comuns de Leucócito/genética
Ativação Linfocitária
Ácido Metrizoico
Microscopia Imunoeletrônica
Povidona
Gravidez
RNA Mensageiro/genética
Receptores de Antígenos de Linfócitos T alfa-beta/metabolismo
Receptores de Antígenos de Linfócitos T gama-delta/metabolismo
Dióxido de Silício
Subpopulações de Linfócitos T/citologia
Subpopulações de Linfócitos T/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (CD3 Complex); 0 (CD56 Antigen); 0 (RNA, Messenger); 0 (Receptors, Antigen, T-Cell, alpha-beta); 0 (Receptors, Antigen, T-Cell, gamma-delta); 25702-74-3 (Ficoll); 65455-52-9 (Percoll); 66720-17-0 (lymphoprep); 7631-86-9 (Silicon Dioxide); CM1N99QR1M (Metrizoic Acid); EC 3.1.3.48 (Leukocyte Common Antigens); FZ989GH94E (Povidone)
[Em] Mês de entrada:0211
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020619
[St] Status:MEDLINE


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[PMID]:11202878
[Au] Autor:Gulabivala K; Abdo S; Sherriff M; Regan JD
[Ad] Endereço:Department of Conservative Dentistry, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK. K.Gulabivala@eastman.ucl.ac.uk
[Ti] Título:The influence of interfacial forces and duration of filing on root canal shaping.
[So] Source:Endod Dent Traumatol;16(4):166-74, 2000 Aug.
[Is] ISSN:0109-2502
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the possible relationship between interfacial forces, duration of instrumentation and effectiveness of root canal shaping by filing. All factors were standardised except the manner of manipulation of the files and the dependent variables (interfacial force and duration of filing). The outcome measured was the final prepared canal shape. The study tested the hypothesis that if interfacial forces and duration of filing had predictive value for effective canal shaping, a relationship between them should be apparent. If it was not, it could be inferred that the remaining uncontrollable variable, "manner of file manipulation" had a dominating influence. 18 operators used a standard filing technique to instrument a root canal each in single rooted teeth matched for anatomy. The teeth were mounted in a custom-made transducer designed to measure laterally applied interfacial forces between file and dentine. The length of time taken with each instrument in the series was measured giving a total duration of instrumentation. The final canal shape measured by standardised "before" and "after" radiographic images of the roots was judged against an "ideal" canal shape calculated from the size of instruments used and based on the preliminary canal shape. Although some trends were revealed, no obvious relationship was demonstrated between interfacial force, duration of filing and final canal shape. Operators clearly used a range of interfacial forces characteristic for each individual and for the different file sizes. Both light and heavy forces could produce a satisfactory canal shape. Use of light or heavy forces did not obviously affect speed of preparation. Tactile discrimination was not dependent on use of light or heavy forces. It was inferred that the "manner of file manipulation" remained undefined and was probably the dominant factor influencing outcome of canal shaping.
[Mh] Termos MeSH primário: Cavidade Pulpar/anatomia & histologia
Preparo de Canal Radicular/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Intervalos de Confiança
Meios de Contraste
Cavidade Pulpar/diagnóstico por imagem
Cavidade Pulpar/fisiologia
Dentina/anatomia & histologia
Dentina/fisiologia
Previsões
Seres Humanos
Modelos Lineares
Ácido Metrizoico
Variações Dependentes do Observador
Avaliação de Resultados (Cuidados de Saúde)
Radiografia
Reprodutibilidade dos Testes
Preparo de Canal Radicular/instrumentação
Limiar Sensorial/fisiologia
Estresse Mecânico
Fatores de Tempo
Raiz Dentária/diagnóstico por imagem
Tato/fisiologia
Transdutores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); CM1N99QR1M (Metrizoic Acid)
[Em] Mês de entrada:0103
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:010224
[St] Status:MEDLINE


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[PMID]:9801143
[Au] Autor:Ryningen A; Holmsen H
[Ad] Endereço:Department of Biochemistry and Molecular Biology, University of Bergen, Norway. anita.ryningen@pki.uib.no
[Ti] Título:Role of autocrine stimulation for the effects of cyclic AMP on protein and lipid phosphorylation in platelets activated by particles.
[So] Source:FEBS Lett;436(3):335-8, 1998 Oct 09.
[Is] ISSN:0014-5793
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have compared responses in platelets stimulated with the particulate materials, Intralipid (liposome-suspension) and a potential contrast medium IEEC (1'-(ethyloxycarbonyloxy)-ethyl-5-acetyl-amino-3-(N-methyl-acetyla mino)-2,4,6-triiodo-benzenecarboxylate coated with human serum albumin), with and without forskolin and inhibitors of autocrine stimulation (IAS: an ADP-removing system of creatine phosphate/creatine phosphokinase; RGDS to prevent fibrinogen/fibronectin binding to GPIIb/IIIa; SQ 29.548 as a TXA2 receptor antagonist; cyproheptadine as a serotonin receptor antagonist; BN 52021 as a platelet-activating factor receptor antagonist). The pattern of tyrosine-phosphorylated proteins, phosphorylation of initial lipids and phosphorylation of pleckstrin (P47) were used as markers for early signal transducing responses, while secretion of ADP+ATP and beta-N-acetyl-glycosaminidase were used as final responses. Intralipid showed no platelet activation except for some weak tyrosine protein phosphorylation that was inhibited by elevated cAMP. IEEC induced strong platelet activation that was partly inhibited by increased levels of cAMP and IAS. The inhibition of elevated cAMP seemed to be due to removal of the G protein-mediated activation from secreted autocrine stimulators either by IAS or forskolin. The remaining activity is a pure effect from IEEC which is not affected by elevated cAMP.
[Mh] Termos MeSH primário: Plaquetas/metabolismo
Proteínas Sanguíneas/metabolismo
Colforsina/farmacologia
AMP Cíclico/sangue
Emulsões Gordurosas Intravenosas/farmacologia
Lipídeos/sangue
Ácido Metrizoico/análogos & derivados
Fosfoproteínas
Ativação Plaquetária
[Mh] Termos MeSH secundário: Difosfato de Adenosina/sangue
Trifosfato de Adenosina/sangue
Plaquetas/efeitos dos fármacos
Meios de Contraste/farmacologia
Grânulos Citoplasmáticos/efeitos dos fármacos
Grânulos Citoplasmáticos/metabolismo
Seres Humanos
Técnicas In Vitro
Lisossomos/efeitos dos fármacos
Lisossomos/metabolismo
Ácido Metrizoico/farmacologia
Fosfatos/sangue
Fosfolipídeos/sangue
Fosforilação
Fosfotirosina/sangue
Ativação Plaquetária/efeitos dos fármacos
Proteína Quinase C/sangue
Albumina Sérica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 ((1'-ethyloxycarbonyloxy)ethyl 5-acetylamino-3-(N-methylacetylamino)-2,4,6-triiodobenzenecarboxylate); 0 (Blood Proteins); 0 (Contrast Media); 0 (Fat Emulsions, Intravenous); 0 (Lipids); 0 (Phosphates); 0 (Phospholipids); 0 (Phosphoproteins); 0 (Serum Albumin); 0 (platelet protein P47); 1F7A44V6OU (Colforsin); 21820-51-9 (Phosphotyrosine); 61D2G4IYVH (Adenosine Diphosphate); 8L70Q75FXE (Adenosine Triphosphate); CM1N99QR1M (Metrizoic Acid); E0399OZS9N (Cyclic AMP); EC 2.7.11.13 (Protein Kinase C)
[Em] Mês de entrada:9811
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:981104
[St] Status:MEDLINE


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[PMID]:9561036
[Au] Autor:Ranganathan RS; Arunachalam T; Song B; Mantha S; Ogan M; Wedeking P; Yost F; Jagoda E; Tweedle M
[Ad] Endereço:Bracco Research USA, Princeton, NJ 08540, USA.
[Ti] Título:Evaluation of N,N'-bis-dimethyldiatrizoic acid analogs as liver imaging agents.
[So] Source:Acad Radiol;5 Suppl 1:S23-7, 1998 Apr.
[Is] ISSN:1076-6332
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Meios de Contraste
Diatrizoato/análogos & derivados
Fígado/diagnóstico por imagem
Ácido Metrizoico/análogos & derivados
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Animais
Diatrizoato/efeitos adversos
Diatrizoato/farmacocinética
Tolerância a Medicamentos
Masculino
Metilação
Ácido Metrizoico/efeitos adversos
Ácido Metrizoico/farmacocinética
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (N,N'-dimethyldiatrizoic acid); 117-96-4 (Diatrizoate); CM1N99QR1M (Metrizoic Acid)
[Em] Mês de entrada:9807
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980430
[St] Status:MEDLINE


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[PMID]:9509977
[Au] Autor:Ferrero D; Tarella C; Cherasco C; Bondesan P; Omedè P; Ravaglia R; Caracciolo D; Castellino C; Pileri A
[Ad] Endereço:Dipartimento di Medicina e Oncologia Sperimentale, Divisione di Ematologia dell' Università di Torino, Azienda Ospedaliera San Giovanni Battista, Italy.
[Ti] Título:A single step density gradient separation for large scale enrichment of mobilized peripheral blood progenitor cells collected for autotransplantation.
[So] Source:Bone Marrow Transplant;21(4):409-13, 1998 Feb.
[Is] ISSN:0268-3369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Peripheral blood leukocytes are becoming the preferred source of hematopoietic progenitor/stem cells for autologous transplantation. However, in vitro purging procedures are complex and expensive when applied to peripheral blood progenitor cells harvests. This is mainly due to the large quantities of nucleated cells present in leukapheresis collections. Aiming to reduce total cellularity without significant loss of CD34+ cells, we developed an in vitro cell separation procedure based on ficoll/metrizoate gradient used at a final density of 1.067 g/ml. To obtain this density, standard Lympho-prep (1.077 g/ml) was diluted with normal saline solution (NaCl 9 g/l). Twenty-six leukapheresis collections (median cellularity 21.1 x 10(9), range 2.8-60) from 14 patients with non-Hodgkin's lymphoma, multiple myeloma or plasma cell leukemia were processed (median two leukaphereses per patient). Mean (+/- s.d.) recovery of total nucleated cells, CD34+ cells and CFU-GM was 20.9 +/- 10%, 74.7 +/- 22% and 70.5 +/- 19%, respectively. Cumulative per patient progenitor cell recovery was always above 50%, and as high as 80% in 10/14 patients, while total cellularity was reduced to a median 21.5% (10-33%) of pre-separation values. Contaminating neoplastic cells, identified by immunofluorescence in five collections, were reduced by 1-2 logs. The results indicate that our density gradient separation is an effective method to reduce total cellularity prior to immunological purging, without significant loss of progenitor cells.
[Mh] Termos MeSH primário: Centrifugação com Gradiente de Concentração/métodos
Transplante de Células-Tronco Hematopoéticas
Leucaférese/métodos
[Mh] Termos MeSH secundário: Antígenos CD34/metabolismo
Purging da Medula Óssea
Ensaio de Unidades Formadoras de Colônias
Ficoll
Células-Tronco Hematopoéticas/imunologia
Células-Tronco Hematopoéticas/patologia
Seres Humanos
Técnicas In Vitro
Leucemia Plasmocitária/terapia
Contagem de Leucócitos
Linfoma não Hodgkin/terapia
Ácido Metrizoico
Mieloma Múltiplo/terapia
Transplante Autólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, CD34); 25702-74-3 (Ficoll); 66720-17-0 (lymphoprep); CM1N99QR1M (Metrizoic Acid)
[Em] Mês de entrada:9806
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980324
[St] Status:MEDLINE


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[PMID]:9204361
[Au] Autor:Vik-Mo H; Danielsen R; Skinningsrud K; Haider T; Bjørkhaug A
[Ad] Endereço:Division of Cardiology, University Hospital Trondheim, Norway.
[Ti] Título:Cardiovascular and electrocardiographic effects of iopentol in left ventricular angiography. Comparison of the low-osmolar, non-ionic iopentol (Imagopaque 350) and the hyper-osmolar, ionic metrizoate meglumine-Na-Ca (Isopaque Coronar 370) in patients with coronary heart disease.
[So] Source:Eur Radiol;7 Suppl 4:S156-61, 1997.
[Is] ISSN:0938-7994
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The aim of the study was to evaluate and compare the hemodynamic and electrocardiographic effects following injection of the non-ionic, low-osmolar contrast medium iopentol (Imagopaque 350, Nycomed Imaging AS, Oslo, Norway) and the ionic, hyper-osmolar contrast medium metrizoate meglumine-Na-Ca (Isopaque Coronar 370, Nycomed Imaging AS, Oslo, Norway) when used for left ventricular angiography. The study was performed in a double-blind, randomized manner in 82 patients with severe coronary heart disease. The patients who received iopentol experienced less adverse events and subjective discomfort of lesser intensity than those who received metrizoate (p = 0.0001). Both contrast media induced a biphasic change in left ventricular (LV) systolic pressure, with an initial fall followed by a prolonged rise, but the alterations were statistically significantly more pronounced with metrizoate than with iopentol. The changes in LV end-diastolic pressure (p = 0.023), and LV negative dP/dt (p = 0.002) were significantly more pronounced with metrizoate than with iopentol. Cardiac output and heart rate increased more with metrizoate, while stroke volume was equally increased by both agents. A prolonged increase in the QT-interval, throughout the 10-min observation period, was seen only after injection of metrizoate (p = 0.0006 for comparison between contrast media). CONCLUSION: Iopentol was well tolerated and induced markedly less severe hemodynamic and electrocardiographic alterations than did metrizoate in patients with severe coronary heart disease.
[Mh] Termos MeSH primário: Meios de Contraste/efeitos adversos
Ácido Metrizoico/análogos & derivados
Ácidos Tri-Iodobenzoicos/efeitos adversos
[Mh] Termos MeSH secundário: Angiocardiografia
Doença das Coronárias/diagnóstico por imagem
Método Duplo-Cego
Eletrocardiografia/efeitos dos fármacos
Feminino
Hemodinâmica/efeitos dos fármacos
Seres Humanos
Masculino
Ácido Metrizoico/efeitos adversos
Meia-Idade
Segurança
Disfunção Ventricular Esquerda/diagnóstico por imagem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Contrast Media); 0 (Triiodobenzoic Acids); 7D6XWX076T (iopentol); CM1N99QR1M (Metrizoic Acid); RJY6JR42WQ (methylglucamine metrizoate)
[Em] Mês de entrada:9707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970101
[St] Status:MEDLINE


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[PMID]:7619627
[Au] Autor:Larsen JL; Skouen JS; Vik H
[Ad] Endereço:Department of Radiology, University Hospital, Bergen, Norway.
[Ti] Título:Contrast media leakage to the cerebrospinal fluid after intravenous injection. Comparison of stroke patients and controls.
[So] Source:Acta Radiol;36(4):440-7, 1995 Jul.
[Is] ISSN:0284-1851
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have tested a method to evaluate leakage of i.v. injected contrast media (CM) through the 3 partitions between blood and cerebrospinal fluid (CSF) in controls and in patients with acute cerebrovascular disease (ACBVD) to detect differences between normal brains and brains with ischemic lesions. High-osmolar (HOCM) and low-osmolar (LOCM) CM were used. In 55 patients and in 41 controls who underwent CT after i.v. contrast administration, lumbar CSF was collected 1 hour after injection and the iodine content in the CSF was measured. The concentration of iodine in CSF was very low, between 0.57 and 11.20 ng/l, and no significant difference could be found between patients and controls or between HOCM and LOCM. We conclude that under the conditions mentioned above, iodine detected in the human lumbar CSF does not reflect the true leakage of contrast agent through the blood-brain barrier.
[Mh] Termos MeSH primário: Transtornos Cerebrovasculares/diagnóstico por imagem
Meios de Contraste/administração & dosagem
Extravasamento de Materiais Terapêuticos e Diagnósticos/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Análise de Variância
Transtornos Cerebrovasculares/líquido cefalorraquidiano
Extravasamento de Materiais Terapêuticos e Diagnósticos/diagnóstico por imagem
Extravasamento de Materiais Terapêuticos e Diagnósticos/etiologia
Feminino
Seres Humanos
Injeções Intravenosas
Iohexol/administração & dosagem
Masculino
Ácido Metrizoico/administração & dosagem
Meia-Idade
Tomografia Computadorizada por Raios X/estatística & dados numéricos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 4419T9MX03 (Iohexol); CM1N99QR1M (Metrizoic Acid)
[Em] Mês de entrada:9508
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950701
[St] Status:MEDLINE



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