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  1 / 4996 MEDLINE  
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[PMID]:28637122
[Au] Autor:Wang ZG; Mi J; Wang XR; Huo YY; Peng YJ; Zhang HM; Gao Y; Zhang HL
[Ad] Endereço:a Department of Pharmaceutical Analysis , Heilongjiang University of Chinese Medicine , Harbin , China.
[Ti] Título:A new cinnamic acid glycoside from roots of Heracleum dissectum.
[So] Source:Nat Prod Res;32(2):133-140, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the roots of Heracleum dissectum Lebb., one new cinnamic acid glycoside derivative named dissectumoside (1), together with eight known compounds including three phenolics, three phenolic glycosides and two phenylpropanoic glycoside were isolated using various chromatographic methods. Among them compound 2-9 was isolated from the plant for the first time. Their structures were elucidated and identified on the basis of their physicochemical properties and by extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. The results of triglyceride accumulation screening in 3T3-L1 cells showed that compounds 1, 5 and 9 exhibited significantly accelerating activities of adipogenesis in adipocytes.
[Mh] Termos MeSH primário: Cinamatos/isolamento & purificação
Glicosídeos/isolamento & purificação
Heracleum/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/efeitos dos fármacos
Adipogenia/efeitos dos fármacos
Animais
Glicosídeos Cardíacos
Cinamatos/química
Glicosídeos/química
Camundongos
Fenóis/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiac Glycosides); 0 (Cinnamates); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1340285


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[PMID]:29345918
[Au] Autor:Villalva M; Jaime L; Aguado E; Nieto JA; Reglero G; Santoyo S
[Ad] Endereço:Institute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM + CSIC) , 28049 Madrid, Spain.
[Ti] Título:Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract.
[So] Source:J Agric Food Chem;66(5):1167-1174, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The potential use of Origanum majorana L. as a source of bioavailable phenolic compounds, specifically rosmarinic acid (RA), has been evaluated. Phenolic bioavailability was tested using an in vitro digestion process followed by a Caco-2 cellular model of intestinal absorption. The high-performance liquid chromatography-photodiode array detector-tandem mass spectrometry (HPLC-PAD-MS/MS) analysis showed the main components in the extract were 6-hydroxyluteolin-7-O-glucoside and rosmarinic acid, followed by luteolin-O-glucoside. After digestion process, the amount of total phenolic compounds (TPC) only decreased slightly, although a remarkable reduction in RA (near 50%) was detected. Bioavailable fraction contained 7.37 ± 1.39 mg/L digested extract of RA with small quantities of lithospermic acid and diosmin and presented an important antioxidant activity (0.89 ± 0.09 mmol Trolox/L digested extract). Besides, this bioavailable fraction produced a significant inhibition in TNF-α, IL-1ß, and IL-6 secretion, using a human THP-1 macrophages model. Therefore, RA content in the basolateral compartment could play an important role in the antioxidant and anti-inflammatory activities found.
[Mh] Termos MeSH primário: Anti-Inflamatórios
Antioxidantes
Cinamatos/farmacologia
Depsídeos/farmacologia
Origanum/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Células CACO-2
Cinamatos/análise
Cinamatos/farmacocinética
Depsídeos/análise
Depsídeos/farmacocinética
Seres Humanos
Absorção Intestinal
Fenóis/farmacocinética
Extratos Vegetais/farmacocinética
Folhas de Planta/química
Células THP-1
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cinnamates); 0 (Depsides); 0 (Phenols); 0 (Plant Extracts); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b06008


  3 / 4996 MEDLINE  
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[PMID]:29351879
[Au] Autor:Szopa A; Starzec A; Ekiert H
[Ad] Endereço:Chair and Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, ul. Medyczna 9, 30-688 Kraków, Poland. Electronic address: a.szopa@uj.edu.pl.
[Ti] Título:The importance of monochromatic lights in the production of phenolic acids and flavonoids in shoot cultures of Aronia melanocarpa, Aronia arbutifolia and Aronia נprunifolia.
[So] Source:J Photochem Photobiol B;179:91-97, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Shoot cultures of Aronia melanocarpa, A. arbutifolia and A. × prunifolia were maintained on Murashige and Skoog medium with 1 mg/l each of BA and NAA under monochromatic lights (far-red, red, blue lights, UV-A-irradiation), in darkness, and under white light (control). HPLC-DAD analyses of 19 phenolic acids and 11 flavonoids in methanolic extracts from the shoots revealed in all of them the presence of three depsides (chlorogenic, neochlorogenic and rosmarinic acids), protocatechuic acid, four flavonoid glycosides (cynaroside, quercitrin, hyperoside and rutoside), and additionally, in A. arbutifolia, 3,4-dihydroxyphenylacetic acid. Depending on light quality, the total amounts of these metabolites increased 1.8-5.9 times, reaching maximum values under blue light: 527.40 and 144.61 mg 100 g DW (A. melanocarpa), 543.27 and 85.82 mg 100 g DW (A. arbutifolia) and 1615.18 and 220.65 mg 100 g DW (A. × prunifolia), respectively. The maximum total amounts were 1.3-3.6 times higher than under white light. The quantities of individual metabolites changed from 1.2 to 11.0 times, with high amounts of neochlorogenic acid and quercitrin in A. melanocarpa (243.35 and 75.64 mg 100 g DW), and of chlorogenic and rosmarinic acids and quercitrin in A. arbutifolia (236.52, 219.35 and 51.01 mg 100 g DW). Extremely high amounts of depsides (418.83, 644.68, 548.86 mg 100 g DW) and quercitrin (165.88 mg 100 g DW) were produced in cultures of the hybrid - A. × prunifolia. The results are potentially useful for practical applications. This is the first report documented the importance of light quality on the production of phenolic acids and flavonoids in three aronia in vitro cultures.
[Mh] Termos MeSH primário: Flavonoides/metabolismo
Hidroxibenzoatos/metabolismo
Luz
Photinia/efeitos da radiação
[Mh] Termos MeSH secundário: Biomassa
Ácido Clorogênico/análise
Ácido Clorogênico/metabolismo
Cromatografia Líquida de Alta Pressão
Cinamatos/análise
Cinamatos/metabolismo
Depsídeos/análise
Depsídeos/metabolismo
Flavonoides/análise
Hidroxibenzoatos/análise
Photinia/química
Photinia/metabolismo
Brotos de Planta/química
Brotos de Planta/metabolismo
Brotos de Planta/efeitos da radiação
Quercetina/análogos & derivados
Quercetina/análise
Quercetina/metabolismo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Depsides); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); 2Y8906LC5P (quercitrin); 318ADP12RI (Chlorogenic Acid); 9IKM0I5T1E (Quercetin); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE


  4 / 4996 MEDLINE  
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[PMID]:29314866
[Au] Autor:Herrlinger KA; Nieman KM; Sanoshy KD; Fonseca BA; Lasrado JA; Schild AL; Maki KC; Wesnes KA; Ceddia MA
[Ad] Endereço:1 Kemin Foods, LC , Des Moines, IA.
[Ti] Título:Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.
[So] Source:J Altern Complement Med;24(1):37-47, 2018 Jan.
[Is] ISSN:1557-7708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI). DESIGN: Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System , Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS ), respectively. RESULTS: Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo. CONCLUSIONS: These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI.
[Mh] Termos MeSH primário: Transtornos da Memória/tratamento farmacológico
Memória de Curto Prazo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Cinamatos
Cognição/efeitos dos fármacos
Depsídeos
Feminino
Seres Humanos
Masculino
Mentha spicata
Meia-Idade
Polifenóis
Sono/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cinnamates); 0 (Depsides); 0 (Plant Extracts); 0 (Polyphenols); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1089/acm.2016.0379


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[PMID]:29374707
[Au] Autor:Uesawa Y; Sakagami H; Okudaira N; Toda K; Takao K; Kagaya H; Sugita Y
[Ad] Endereço:Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Tokyo, Japan uesawa@my-pharm.ac.jp.
[Ti] Título:Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.
[So] Source:Anticancer Res;38(2):817-823, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Many phenolic acid phenethyl esters possess diverse biological effects including antioxidant, cytoprotective, anti-inflammation and anti-tumor activities. However, most previous antitumor studies have not considered the cytotoxicity against normal cells. Ten cinnamic acid phenetyl esters were subjected to quantitative structure-activity relationship (QSAR) analysis, based on their cytotoxicity and tumor-specificity, in order to find their new biological activities. MATERIALS AND METHODS: Cytotoxicity against four human oral squamous cell carcinoma cell lines and three oral normal mesenchymal cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Tumor specificity (TS) was evaluated by the ratio of the mean 50% cytotoxic concentration (CC ) against normal oral cells to that against human oral squamous cell carcinoma cell lines. Potency-selectivity expression (PSE) value was calculated by dividing the TS value by CC against tumor cells. Apoptosis markers were detected by western blot analysis. Physicochemical, structural and quantum-chemical parameters were calculated based on the conformations optimized by force-field minimization. RESULTS: Western blot analysis demonstrated that [ ] stimulated the cleavage of caspase-3, suggesting the induction of apoptosis. QSAR analysis demonstrated that TS values were correlated with shape, size and ionization potential. CONCLUSION: Chemical modification of the lead compound may be a potential choice for designing a new type of anticancer drugs.
[Mh] Termos MeSH primário: Cinamatos/farmacologia
Ésteres/farmacologia
Álcool Feniletílico/farmacologia
[Mh] Termos MeSH secundário: Carcinoma de Células Escamosas/tratamento farmacológico
Carcinoma de Células Escamosas/patologia
Linhagem Celular Tumoral
Criança
Cinamatos/química
Cinamatos/toxicidade
Ésteres/química
Ésteres/toxicidade
Fibroblastos/efeitos dos fármacos
Neoplasias de Cabeça e Pescoço/tratamento farmacológico
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Masculino
Neoplasias Bucais/tratamento farmacológico
Neoplasias Bucais/patologia
Álcool Feniletílico/química
Álcool Feniletílico/toxicidade
Relação Quantitativa Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Esters); ML9LGA7468 (Phenylethyl Alcohol); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


  6 / 4996 MEDLINE  
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[PMID]:29447012
[Au] Autor:Gao X; Tang J; Liu H; Liu L; Kang L; Chen W
[Ad] Endereço:a Key Laboratory Breeding Base of Hu'nan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, College of Pharmacy , Changsha Medical University , Changsha , China.
[Ti] Título:Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid.
[So] Source:J Enzyme Inhib Med Chem;33(1):519-524, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d-6g, 10d-12g, 16d-18g and 22d-24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. The results revealed that the alteration of aminoalkyl types and substituted positions markedly influences the effects in inhibiting AChE. Almost of all cinnamic acid derivatives had the most potent inhibitory activity than that of other acid derivatives with the same aminoalkyl side chain. Unsaturated bond and benzene ring in cinnamic acid scaffold seems important for the inhibitory activity against AChE. Among them, compound 6g revealed the most potent AChE inhibitory activity (IC value: 3.64 µmol/L) and highest selectivity over BChE (ratio: 28.6). Enzyme kinetic study showed that it present a mixed-type inhibition against AChE. The molecular docking study suggested that it can bind with the catalytic site and peripheral site of AChE.
[Mh] Termos MeSH primário: Aminas/farmacologia
Caproatos/farmacologia
Inibidores da Colinesterase/farmacologia
Cinamatos/farmacologia
Fenilpropionatos/farmacologia
Ácido Sórbico/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Aminas/síntese química
Aminas/química
Animais
Butirilcolinesterase/metabolismo
Caproatos/química
Inibidores da Colinesterase/síntese química
Inibidores da Colinesterase/química
Cinamatos/química
Relação Dose-Resposta a Droga
Simulação de Acoplamento Molecular
Estrutura Molecular
Fenilpropionatos/química
Ratos
Ratos Sprague-Dawley
Ácido Sórbico/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Caproates); 0 (Cholinesterase Inhibitors); 0 (Cinnamates); 0 (Phenylpropionates); 1F8SN134MX (hexanoic acid); 5Q445IN5CU (3-phenylpropionic acid); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); U14A832J8D (cinnamic acid); X045WJ989B (Sorbic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1436053


  7 / 4996 MEDLINE  
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[PMID]:29262714
[Au] Autor:Karadag B; Yücel NC
[Ad] Endereço:Department of Chemistry, Faculty of Science, Dokuz Eylul University , Buca, 35390, Izmir , Turkey.
[Ti] Título:Cinnamic acid and fish flour affect wheat phenolic acids and flavonoid compounds, lipid peroxidation, proline levels under salt stress.
[So] Source:Acta Biol Hung;68(4):388-397, 2017 Dec.
[Is] ISSN:0236-5383
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:To elucidate the physiological mechanism of salt stress mitigated by cinnamic acid (CA) and fish flour (FF) pretreatment, wheat was pretreated with 20, 50 and 100 ppm CA and 1 g/10 mL FF for 2 d and was then cultivated. We investigated whether exogenous CA + FF could protect wheat from salt stress and examined whether the protective effect was associated with the regulation of seed vigor, antioxidant defense systems, phenolic biosynthesis and lipid peroxidation. At 2 days exogenous CA did not influence seed vigor. Salt stress increased the phenolic biosynthesis, but the CA + FF-combined pretreatment enhanced the phenolic biosynthesis even more under salt stress and decreased lipid peroxidation to some extent, enhancing the tolerance of wheat to salt stress.
[Mh] Termos MeSH primário: Cinamatos/metabolismo
Farinha de Peixe
Flavonoides/metabolismo
Hidroxibenzoatos/metabolismo
Peroxidação de Lipídeos
Pressão Osmótica
Triticum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1556/018.68.2017.4.5


  8 / 4996 MEDLINE  
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[PMID]:29394017
[Au] Autor:Kanlayavattanakul M; Kasikawatana N; Lourith N
[Ti] Título:Analysis of octyl methoxycinnamate in sunscreen products by a validated UV-spectrophotometric method.
[So] Source:J Cosmet Sci;67(3):167-73, 2016 May-Jun.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An inexpensive, rapid method for the determination of octyl methoxycinnamate (OMC) in sunscreen products using ultraviolet-spectrophotometry has been developed and validated according to International Council for Harmonisation and Association of Official Analytical Chemists guidelines. Methanol was the optimal solvent used with a linearity range of 4­12 µg\/ml (r = 0.999) being obtainable. The accuracy of the method is highlighted by the % recovery (98.23­98.50) and relative standard deviation (%RSD, 0.12), and it is widely applicable to prototype products composed of oil in water, and water in oil emulsions. Mineral oils containing low, intermediate, and high OMC levels (1%, 4%, and 7.5%) gave recovery percentages of 99.76­100.76 with %RSD of 0.02­0.28. In addition, this method is repeatable and affords a high degree of precision (%RSD = 0.12 and 0) with 96.08­99.27% recovery. The method is suitable for quality assurance of suncare product formulations, and could be applicable to product development and validation.
[Mh] Termos MeSH primário: Cinamatos/química
Protetores Solares/química
[Mh] Termos MeSH secundário: Composição de Medicamentos
Seres Humanos
Reprodutibilidade dos Testes
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Sunscreening Agents); 4Y5P7MUD51 (octylmethoxycinnamate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29278947
[Au] Autor:Chen Y; Zhu J; Mo J; Yang H; Jiang X; Lin H; Gu K; Pei Y; Wu L; Tan R; Hou J; Chen J; Lv Y; Bian Y; Sun H
[Ad] Endereço:a School of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , China.
[Ti] Título:Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
[So] Source:J Enzyme Inhib Med Chem;33(1):290-302, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer's disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure-activity relationship study and biological evaluation of a series of tacrine-cinnamic acid hybrids as new ChEIs. All target compounds are evaluated for their in vitro cholinesterase inhibitory activities. The representatives which show potent activity on cholinesterase, are evaluated for the amyloid ß-protein self-aggregation inhibition and in vivo assays. The optimal compound 19, 27, and 30 (human AChE IC = 10.2 ± 1.2, 16.5 ± 1.7, and 15.3 ± 1.8 nM, respectively) show good performance in ameliorating the scopolamine-induced cognition impairment and preliminary safety in hepatotoxicity evaluation. These compounds deserve further evaluation for the development of new therapeutic agents against AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Inibidores da Colinesterase/farmacologia
Cinamatos/farmacologia
Tacrina/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Doença de Alzheimer/metabolismo
Peptídeos beta-Amiloides/antagonistas & inibidores
Peptídeos beta-Amiloides/metabolismo
Animais
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/síntese química
Inibidores da Colinesterase/química
Cinamatos/química
Relação Dose-Resposta a Droga
Electrophorus
Cavalos
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos ICR
Modelos Moleculares
Estrutura Molecular
Agregados Proteicos/efeitos dos fármacos
Relação Estrutura-Atividade
Tacrina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Cholinesterase Inhibitors); 0 (Cinnamates); 0 (Protein Aggregates); 4VX7YNB537 (Tacrine); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1412314


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[PMID]:28464271
[Au] Autor:Yang X; Gao W; Wang B; Wang X; Guo H; Xiao Y; Kong L; Hao D
[Ad] Endereço:Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.
[Ti] Título:Picroside II Inhibits RANKL-Mediated Osteoclastogenesis by Attenuating the NF-κB and MAPKs Signaling Pathway In Vitro and Prevents Bone Loss in Lipopolysaccharide Treatment Mice.
[So] Source:J Cell Biochem;118(12):4479-4486, 2017 Dec.
[Is] ISSN:1097-4644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Picroside II, one of the major components isolated from the seed of natural plant picrorhiza, is widely used in traditional Chinese medicine. The present study was performed to define effects of picroside II on nuclear factor-kappaB ligand (RANKL)-stimulated osteoclast differentiation in vitro and on lipopolysaccharide (LPS)-induced bone loss in vivo. The bone marrow cells (BMMs) were harvested and induced with RANKL followed by treatment with picroside II at several doses, and the differentiation of osteoclasts from these cells was evaluated by tartrate-resistant acid phosphatase (TRAP) staining and resorption pit formation assay. The effects of picroside II on osteoclastogenesis were studied by examining RANKL-induced osteoclast F-actin ring formation and osteoclast bone resorption. Moreover, we explored the mechanisms of these downregulation effects by performed Western blotting and quantitative RT-PCR examination. Results demonstrated picroside II strongly inhibited RANKL-induced osteoclast formation when added during the early stage of BMMs cultures, suggesting that it acts on osteoclast precursors to inhibit RANKL/RANK signaling. Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-κB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis. Furthermore, in vivo studies verified the bone protection effects of picroside II. These results collectively suggested that picroside II acted as an anti-resorption agent by blocking osteoclast activation. J. Cell. Biochem. 118: 4479-4486, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Cinamatos/farmacologia
Glucosídeos Iridoides/farmacologia
Lipopolissacarídeos/toxicidade
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
NF-kappa B/metabolismo
Osteoclastos/metabolismo
Osteólise
Receptor Ativador de Fator Nuclear kappa-B/metabolismo
[Mh] Termos MeSH secundário: Animais
Camundongos
Osteoclastos/patologia
Osteólise/induzido quimicamente
Osteólise/metabolismo
Osteólise/patologia
Osteólise/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Iridoid Glucosides); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Receptor Activator of Nuclear Factor-kappa B); 0 (Tnfrsf11a protein, mouse); 39012-20-9 (picroside II)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/jcb.26105



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