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  1 / 1904 MEDLINE  
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[PMID]:29194017
[Au] Autor:Abdul Manan FM; Attan N; Widodo N; Aboul-Enein HY; Wahab RA
[Ad] Endereço:a Department of Chemistry, Faculty of Science , Universiti Teknologi Malaysia , Skudai , Malaysia.
[Ti] Título:Rhizomucor miehei lipase immobilized on reinforced chitosan-chitin nanowhiskers support for synthesis of eugenyl benzoate.
[So] Source:Prep Biochem Biotechnol;48(1):92-102, 2018 Jan 02.
[Is] ISSN:1532-2297
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An alternative environmentally benign support was prepared from chitosan-chitin nanowhiskers (CS/CNWs) for covalent immobilization of Rhizomucor miehei lipase (RML) to increase the operational stability and recyclability of RML in synthesizing eugenyl benzoate. The CS/CNWs support and RML-CS/CNWs were characterized using X-ray diffraction, fluorescent microscopy, and Fourier transform infrared spectroscopy. Efficiency of the RML-CS/CNWs was compared to the free RML to synthesize eugenyl benzoate for parameters: reaction temperature, stirring rate, reusability, and thermal stability. Under optimal experimental conditions (50°C, 250 rpm, catalyst loading 3 mg/mL), a twofold increase in yield of eugenyl benzoate was observed for RML-CS/CNWs as compared to free RML, with the former achieving maximum yield of the ester at 62.1% after 5 hr. Results demonstrated that the strategy adopted to prepare RML-CS/CNWs was useful, producing an improved and prospectively greener biocatalyst that supported a sustainable process to prepare eugenyl benzoate. Moreover, RML-CS/CNWs are biodegradable and perform esterification reactions under ambient conditions as compared to the less eco-friendly conventional acid catalyst. This research provides a facile and promising approach for improving activity of RML in which the resultant RML-CS/CNWs demonstrated good operational stability for up to eight successive esterification cycles to synthesize eugenyl benzoate.
[Mh] Termos MeSH primário: Benzoatos/metabolismo
Quitina/química
Quitosana/química
Enzimas Imobilizadas/metabolismo
Eugenol/análogos & derivados
Lipase/metabolismo
Rhizomucor/enzimologia
[Mh] Termos MeSH secundário: Benzoatos/química
Estabilidade Enzimática
Enzimas Imobilizadas/química
Esterificação
Eugenol/metabolismo
Microbiologia Industrial
Lipase/química
Nanoestruturas/química
Rhizomucor/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Enzymes, Immobilized); 1398-61-4 (Chitin); 3T8H1794QW (Eugenol); 9012-76-4 (Chitosan); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1080/10826068.2017.1405021


  2 / 1904 MEDLINE  
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[PMID]:29328669
[Au] Autor:Feng Y; Wang S; Wang H; Peng Y; Zheng J
[Ad] Endereço:Wuya College of Innovation, Shenyang Pharmaceutical University , Shenyang, Liaoning 110016, People's Republic of China.
[Ti] Título:Urinary Methyleugenol-deoxyadenosine Adduct as a Potential Biomarker of Methyleugenol Exposure in Rats.
[So] Source:J Agric Food Chem;66(5):1258-1263, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity. In this work, a non-invasive approach to determine ME exposure was established by monitoring the urinary N -(methylisoeugenol-3'-yl)-2'-deoxyadenosine (ME-dA) adduct. The developed method entails liquid-liquid extraction enrichment of urinary ME-dA, incorporation of deuterated ME-dA as an internal standard, and analysis by liquid chromatography coupled tandem mass spectrometry. Male rats (10-12 weeks, 180-200 g) were treated (p.o.) with ME, and ME-dA was excreted in urine in a dose- and time-dependent manner. The non-invasive approach enabled us to successfully determine exposure to ME-containing herbs and spices. These results suggest that ME-dA can potentially serve as an effective biomarker of ME exposure in rats. It is expected that the developed approach of detecting urinary ME-dA will facilitate the investigation of ME carcinogenesis.
[Mh] Termos MeSH primário: Biomarcadores/urina
Carcinógenos
Adutos de DNA/urina
Desoxiadenosinas/urina
Eugenol/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Eugenol/análise
Eugenol/toxicidade
Eugenol/urina
Neoplasias Hepáticas/induzido quimicamente
Masculino
Ratos
Ratos Sprague-Dawley
Especificidade da Espécie
Especiarias/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Carcinogens); 0 (DNA Adducts); 0 (Deoxyadenosines); 29T9VA6R7M (methyleugenol); 3T8H1794QW (Eugenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05186


  3 / 1904 MEDLINE  
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[PMID]:29328639
[Au] Autor:Dubovina D; Mihailovic B; Bukumiric Z; Vlahovic Z; Miladinovic M; Mikovic N; Lazic Z
[Ti] Título:The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis.
[So] Source:Vojnosanit Pregl;73(11):1010-5, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Alveolar osteitis (AO), also known as "dry socket", is relatively common post-extraction complication. It probably occurs due to excessive fibrinolytic activity in the coagulum and is characterized by intense pain sensations. The aim of this clinical study was to examine the role of hyaluronic acid and aminocaproic acid in the treatment of AO. Methods: The study included 60 patients with the clinical diagnosis of AO. All the patients were divided into two groups of 30 patients each according to the applied non-pharmacological measure: irrigation ­ irrigation of dry socket with sterile saline; curettage ­ careful curettage. Both of these groups were further divided into three subgroups regarding the applied treatment (hyaluronic acid; hyaluronic acid + aminocaproic acid; Alvogyl ®, an anesthetic and antiseptic paste), each with 10 patients, according to the following protocol: 0.2 mL of hyaluronic acid in the form of a 0.8% gel; 2 mL of aminocaproic acid and hyaluronic acid; Alvogyl®. During each visit, scheduled for every two days until complete absence of painful sensations, the patients had the therapeutic method repeated as at the first examination. At each control visit the number of present symptoms and signs of AO was recorded, as well as the level of pain (measured with a visual analogue scale). Results: With the use of hyaluronic acid, with or without aminocaproic one, a statistically significantly faster reduction in pain sensations was achieved, along with the reduction in the number of symptoms and signs of AO compared to the use of Alvogyl®. Conclusion: Hyaluronic acid, applied alone or in combination with aminocaproic acid significantly reduces pain sensation, thus it can be successfully used in the treatment of AO.
[Mh] Termos MeSH primário: Ácido Aminocaproico/uso terapêutico
Analgésicos/uso terapêutico
Alvéolo Seco/tratamento farmacológico
Eugenol/uso terapêutico
Dor Facial/prevenção & controle
Ácido Hialurônico/uso terapêutico
Hidrocarbonetos Iodados/uso terapêutico
Óleos Voláteis/uso terapêutico
para-Aminobenzoatos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Ácido Aminocaproico/efeitos adversos
Analgésicos/efeitos adversos
Curetagem/efeitos adversos
Combinação de Medicamentos
Alvéolo Seco/diagnóstico
Eugenol/efeitos adversos
Dor Facial/diagnóstico
Dor Facial/etiologia
Dor Facial/fisiopatologia
Feminino
Seres Humanos
Ácido Hialurônico/efeitos adversos
Hidrocarbonetos Iodados/efeitos adversos
Masculino
Meia-Idade
Óleos Voláteis/efeitos adversos
Medição da Dor
Percepção da Dor/efeitos dos fármacos
Limiar da Dor/efeitos dos fármacos
Estudos Prospectivos
Sérvia
Irrigação Terapêutica
Fatores de Tempo
Resultado do Tratamento
para-Aminobenzoatos/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics); 0 (Drug Combinations); 0 (Hydrocarbons, Iodinated); 0 (Oils, Volatile); 0 (butyl aminobenzoate, eugenol, iodoform, spearmint oil drug combinations); 0 (para-Aminobenzoates); 3T8H1794QW (Eugenol); 9004-61-9 (Hyaluronic Acid); U6F3787206 (Aminocaproic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150304125D


  4 / 1904 MEDLINE  
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ALVARENGA, Elson Santiago
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[PMID]:29286652
[Au] Autor:Pinheiro PF; Menini LAP; Bernardes PC; Saraiva SH; Carneiro JWM; Costa AV; Arruda TR; Lage MR; Gonçalves PM; Bernardes CO; Alvarenga ES; Menini L
[Ti] Título:Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties.
[So] Source:J Agric Food Chem;66(1):323-330, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Semisynthetic phenol derivatives were obtained from the natural phenols: thymol, carvacrol, eugenol, and guaiacol through catalytic oxychlorination, Williamson synthesis, and aromatic Claisen rearrangement. The compounds characterization was carried out by H NMR, C NMR, and mass spectrometry. The natural phenols and their semisynthetic derivatives were tested for their antimicrobial activity against the bacteria: Staphylococcus aureus, Escherichia coli, Listeria innocua, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Salmonella enterica ssp. enterica, and Bacillus cereus. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values were determined using concentrations from 220 to 3.44 µg mL . Most of the tested compounds presented MIC values ≤220 µg mL for all the bacteria used in the assays. The molecular properties of the compounds were computed with the PM6 method. Through principle components analysis, the natural phenols and their semisynthetic derivatives with higher antimicrobial potential were grouped.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antibacterianos/farmacologia
Fenol/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Escherichia coli/efeitos dos fármacos
Eugenol/química
Eugenol/farmacologia
Listeria/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Monoterpenos/química
Monoterpenos/farmacologia
Fenol/síntese química
Fenol/química
Salmonella typhimurium/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
Timol/química
Timol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Monoterpenes); 339NCG44TV (Phenol); 3J50XA376E (Thymol); 3T8H1794QW (Eugenol); 9B1J4V995Q (carvacrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04418


  5 / 1904 MEDLINE  
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[PMID]:29251511
[Au] Autor:Celebioglu A; Yildiz ZI; Uyar T
[Ad] Endereço:Institute of Materials Science & Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University , Ankara 06800, Turkey.
[Ti] Título:Fabrication of Electrospun Eugenol/Cyclodextrin Inclusion Complex Nanofibrous Webs for Enhanced Antioxidant Property, Water Solubility, and High Temperature Stability.
[So] Source:J Agric Food Chem;66(2):457-466, 2018 Jan 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, inclusion complexes (IC) of three cyclodextrin derivatives (HP-ß-CD, HP-γ-CD, and M-ß-CD) with eugenol (essential oil compound) were formed in highly concentrated aqueous solutions and then transformed into self-standing functional nanofibrous webs by electrospinning. The improved aqueous solubility of eugenol was confirmed by phase solubility diagrams, in addition, the phase solubility tests also revealed 1:1 molar ratio complexation between host:guest molecules; CD:eugenol. Even though eugenol has a volatile nature, a large amount of eugenol (∼70-95%) was preserved in eugenol/cyclodextrin inclusion complex nanofibrous webs (eugenol/CD/IC-NW). Moreover, enhanced thermal stability of eugenol was recorded for eugenol/CD/IC-NW (up to ∼310 °C) when compared to pure form of eugenol (up to ∼200 °C). The eugenol/CD/IC-NW exhibited fast dissolving behavior in water, contrary to poorly water-soluble eugenol. It was observed that the complexation between M-ß-CD and eugenol was the strongest when compared to other two host CD molecules (HP-ß-CD and HP-γ-CD) for eugenol/CD/IC-NW samples. The electrospun eugenol/CD/IC-NW samples have shown enhanced antioxidant activity compared to pure form of eugenol. In summary, cyclodextrin inclusion complexes of essential oil compounds, such as eugenol, in the form of self-standing nanofibrous webs may have potentials for food and oral-care applications due to their particularly large surface area along with fast-dissolving character, improved water solubility, high temperature stability, and enhanced antioxidant activity.
[Mh] Termos MeSH primário: Antioxidantes/química
Ciclodextrinas/química
Eugenol/química
Nanofibras/química
[Mh] Termos MeSH secundário: Técnicas Eletroquímicas
Solubilidade
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cyclodextrins); 3T8H1794QW (Eugenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04312


  6 / 1904 MEDLINE  
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[PMID]:28749029
[Au] Autor:Shepherd M; Savins D; Dowell A; Morrow S; Allen G; Southwell I
[Ad] Endereço:Southern Cross Plant Science, Southern Cross University, Lismore, NSW, 2480, Australia.
[Ti] Título:Ecotype Variation of Methyl Eugenol Content in Tea Tree (Melaleuca alternifolia and Melaleuca linariifolia).
[So] Source:Chem Biodivers;14(11), 2017 Nov.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics, and health-care. As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. Consequently, its level has been restricted in some foodstuffs and cosmetics for some markets. In order to assess the potential to breed uniformly low methyl eugenol cultivars for an essential oil crop, tea tree, the source of 'Oil of Melaleuca, terpinene-4-ol type', we examine levels in individual trees (n = 30) from two geographic regions and six terpene chemotypes. Overall, methyl eugenol levels were low in this species (Mean [SD] 354 [239] ppm, n = 30), much lower than levels predicted to be of toxicological concern. Within each chemotype, there was a lack of evidence for correlations between terpenoid constituents and methyl eugenol levels. Further support for the independence of methyl eugenol and terpene biosynthesis was evident from similar mean levels in selected (Mean [SD] 586 [339] ppm, n = 12) and undomesticated Melaleuca alternifolia trees (Mean [SD] 480 [299] ppm, n = 5) with terpinen-4-ol type oils. By contrast, methyl eugenol level varied by geographic origin and chemotype. Trees from the upland region, where there is a prevalence of terpinolene type trees, had lower average methyl eugenol levels than trees from the coastal region, where there is a prevalence of terpinen-4-ol and 1,8-cineole type trees.
[Mh] Termos MeSH primário: Eugenol/análogos & derivados
Cromatografia Gasosa-Espectrometria de Massas
Melaleuca/química
[Mh] Termos MeSH secundário: Calibragem
Cromatografia Gasosa
Ecótipo
Eugenol/análise
Eugenol/química
Eugenol/normas
Cromatografia Gasosa-Espectrometria de Massas/normas
Limite de Detecção
Melaleuca/metabolismo
Óleos Voláteis/química
Terpenos/análise
Terpenos/química
Terpenos/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Terpenes); 29T9VA6R7M (methyleugenol); 3T8H1794QW (Eugenol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700278


  7 / 1904 MEDLINE  
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[PMID]:28854647
[Au] Autor:Vargas RI; Souder SK; Morse JG; Grafton-Cardwell EE; Haviland DR; Kabashima JN; Faber BA; Mackey B; Nkomo E; Cook PJ; Stark JD
[Ad] Endereço:USDA-ARS, Daniel K. Inouye U.S. Pacific Basin Agricultural Research Center, 64 Nowelo St, Hilo, HI 96720.
[Ti] Título:Chemical Degradation of TMR Multilure Dispensers for Fruit Fly Detection Weathered Under California Climatic Conditions.
[So] Source:J Econ Entomol;110(4):1495-1500, 2017 Aug 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Degradation models for multilure fruit fly trap dispensers were analyzed to determine their potential for use in large California detection programs. Solid three-component male lure TMR (trimedlure [TML], methyl eugenol [ME], raspberry ketone [RK]) dispensers impregnated with DDVP (2, 2-dichlorovinyl dimethyl phosphate) insecticide placed inside Jackson traps were weathered during summer (8 wk) and winter (12 wk) in five citrus-growing areas. Additionally, TMR wafers without DDVP, but with an insecticidal strip, were compared to TMR dispensers with DDVP. Weathered dispensers were sampled weekly and chemically analyzed. Percent loss of TML, the male lure for Ceratitis capitata (Wiedemann) Mediterranean fruit fly; ME, the male lure for Bactrocera dorsalis (Hendel), oriental fruit fly; RK, the male lure for Bactrocera cucurbitae (Coquillett), melon fly; and DDVP was measured. Based on regression analyses for the male lures, TML degraded the fastest followed by ME. Degradation of the more chemically stable RK was discontinuous, did not fit a regression model, but followed similar seasonal patterns. There were few location differences for all three male lures and DDVP. Dispensers degraded faster during summer than winter. An asymptotic regression model provided a good fit for % loss (ME, TML, and DDVP) for summer data. Degradation of DDVP in TMR dispensers was similar to degradation of DDVP in insecticidal strips. Based on these chemical analyses and prior bioassay results with wild flies, TMR dispensers could potentially be used in place of three individual male lure traps, reducing costs of fruit fly survey programs. Use of an insecticidal tape would not require TMR dispensers without DDVP to be registered with US-EPA.
[Mh] Termos MeSH primário: Diclorvós/química
Controle de Insetos/métodos
Feromônios/química
[Mh] Termos MeSH secundário: Animais
Butanonas/química
California
Ceratitis capitata/fisiologia
Ácidos Cicloexanocarboxílicos/química
Eugenol/análogos & derivados
Eugenol/química
Inseticidas/química
Masculino
Tephritidae/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanones); 0 (Cyclohexanecarboxylic Acids); 0 (Insecticides); 0 (Pheromones); 0 (insect attractants); 1H2MQB7WZ9 (trimedlure); 29T9VA6R7M (methyleugenol); 3T8H1794QW (Eugenol); 7QY1MH15BG (raspberry ketone); 7U370BPS14 (Dichlorvos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox159


  8 / 1904 MEDLINE  
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[PMID]:28826085
[Au] Autor:Charan Raja MR; Velappan AB; Chellappan D; Debnath J; Kar Mahapatra S
[Ad] Endereço:Department of Biotechnology, School of Chemical and Biotechnology, SASTRA University, Thanjavur, India.
[Ti] Título:Eugenol derived immunomodulatory molecules against visceral leishmaniasis.
[So] Source:Eur J Med Chem;139:503-518, 2017 Oct 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Visceral leishmaniasis (VL) is a life threatening infectious disease caused by Leishmania donovani. It leads to the severe immune suppression in the host defense system. Higher cytotoxicity, rigorous side effects and lower therapeutic indexes (TI) of current antileishmanial drugs have created a necessity to develop new molecules with better antileishmanial activity and high TI value. In this study, we have synthesized 36 derivatives of eugenol and screened them for their activity against promastigote and amastigote forms of L. donovani. Among the synthesized derivatives, comp.35 showed better antileishmanial activity against extra cellular promastigotes (IC - 20.13 ± 0.91 µM) and intracellular amastigotes (EC -4.25 ± 0.26 µM). The TI value (82.24 ± 3.77) was found to improve by 10-13 fold compared to Amphotericin B and Miltefosine respectively. Treatment with comp.35 (5 µg/ml) enhanced the nitric oxide (NO) generation, iNOS2 mRNA expression (∼8 folds increase) and decreased the arginase-1 activity (∼4 folds) in L. donovani infected peritoneal macrophages. Comp.35 had also increased the IL-12 (∼6 folds) and decreased the IL-10 (∼3 folds) mRNA expression and release in vitro. Results of in vivo studies revealed that comp.35 treatment at 25 mg/kg body weight efficiently cleared the hepatic and splenic parasite burden with enhanced Th1 response in L. donovani infected BALB/c mice. Hence, this study clearly represents comp.35, as an immunomodulatory molecule, can induce host protective immune response against visceral leishmaniasis through enhanced NO generation and Th1 response, which are essentials against this deadly disease.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Eugenol/farmacologia
Imunomodulação
Leishmania donovani/efeitos dos fármacos
Leishmaniose Visceral/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/síntese química
Antiprotozoários/química
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Eugenol/síntese química
Eugenol/química
Leishmania donovani/citologia
Macrófagos/efeitos dos fármacos
Macrófagos/parasitologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Estrutura Molecular
Testes de Sensibilidade Parasitária
Células RAW 264.7
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 3T8H1794QW (Eugenol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


  9 / 1904 MEDLINE  
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[PMID]:28763946
[Au] Autor:Resende DB; Martins HHA; Souza TB; Carvalho DT; Piccoli RH; Schwan RF; Dias DR
[Ad] Endereço:Federal University of Lavras, Department of Biology, P.O. Box 3037, 37200-000 Lavras, MG, Brazil.
[Ti] Título:Synthesis and in vitro evaluation of peracetyl and deacetyl glycosides of eugenol, isoeugenol and dihydroeugenol acting against food-contaminating bacteria.
[So] Source:Food Chem;237:1025-1029, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Essential oils, as well as their separate components, have shown promise as alternatives to synthetic preservatives. Therefore, it would be interesting to optimize the effect of these compounds and to evaluate their applicability as additives in food. To this end, six peracetyl and deacetyl glycosides were synthesized from eugenol, isoeugenol and dihydroeugenol. All of the glycosides were characterized by IR and NMR. The synthesized compounds and their aglycones were evaluated to determine their minimal bactericidal concentrations (MBC) against the spoilage food bacteria Escherichia coli, Listeria monocytogenes, Staphylococcus aureus and Salmonella enteritidis. All deacetyl glycosides were about twice as active as aglycones, and the peracetyl glycosides were, in most cases, equipotent with aglycones. The deacetyl glycoside of dihydroeugenol proved to be the most active compound against the bacteria tested, with a 0.37% MBC v/v for E. coli and 0.18% v/v for the other bacteria.
[Mh] Termos MeSH primário: Microbiologia de Alimentos
Glicosídeos/análise
[Mh] Termos MeSH secundário: Antibacterianos
Escherichia coli
Eugenol/análogos & derivados
Listeria monocytogenes
Testes de Sensibilidade Microbiana
Óleos Voláteis
Staphylococcus aureus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glycosides); 0 (Oils, Volatile); 3T8H1794QW (Eugenol); 5M0MWY797U (isoeugenol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28733207
[Au] Autor:Ma N; Karam I; Liu XW; Kong XJ; Qin Z; Li SH; Jiao ZH; Dong PC; Yang YJ; Li JY
[Ad] Endereço:Key Lab of New Animal Drug Project of Gansu Province, Key Lab of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Science of Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R. China.
[Ti] Título:UPLC-Q-TOF/MS-based urine and plasma metabonomics study on the ameliorative effects of aspirin eugenol ester in hyperlipidemia rats.
[So] Source:Toxicol Appl Pharmacol;332:40-51, 2017 Oct 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The main objective of this study was to investigate the ameliorative effects of aspirin eugenol ester (AEE) in hyperlipidemic rat. After five-week oral administration of AEE in high fat diet (HFD)-induced hyperlipidemic rats, the impact of AEE on plasma and urine metabonomics was investigated to explore the underlying mechanism by UPLC-Q-TOF/MS analysis. Blood lipid levels and histopathological changes of liver, stomach and duodenum were also evaluated after AEE treatment. Without obvious gastrointestinal (GI) side effects, AEE significantly relieved fatty degeneration of liver and reduced triglyceride (TG), low density lipoprotein (LDL) and total cholesterol (TCH) (P<0.01). Clear separations of metabolic profiles were observed among control, model and AEE groups by using principal component analysis (PCA) and orthogonal partial least-squares-discriminate analysis (OPLS-DA). 16 endogenous metabolites in plasma and 18 endogenous metabolites in urine involved in glycerophospholipid metabolism, fatty acid metabolism, fatty acid beta-oxidation, amino acid metabolism, TCA cycle, sphingolipid metabolism, gut microflora and pyrimidine metabolism were considered as potential biomarkers of hyperlipidemia and be regulated by AEE administration. It might be concluded that AEE was a promising drug candidate for hyperlipidemia treatment. These findings could contribute to the understanding of action mechanisms of AEE and provide evidence for further studies.
[Mh] Termos MeSH primário: Aspirina/análogos & derivados
Dieta Hiperlipídica
Eugenol/análogos & derivados
Hiperlipidemias/sangue
Hiperlipidemias/urina
Metabolômica
[Mh] Termos MeSH secundário: Administração Oral
Animais
Aspirina/farmacologia
Biomarcadores/sangue
Biomarcadores/urina
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Eugenol/farmacologia
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Análise Multivariada
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (aspirin eugenol ester); 3T8H1794QW (Eugenol); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE



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