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[PMID]:28610437
[Au] Autor:Song Y; Zhou J; Wang X; Xie X; Zhao Y; Ni F; Huang W; Wang Z; Xiao W
[Ad] Endereço:a Jiangsu Kanion Pharmaceutical Co., Ltd. , Lianyungang , People's Republic of China.
[Ti] Título:A new ferulic acid ester from Rhodiola wallichiana var. cholaensis (Crassulaceae).
[So] Source:Nat Prod Res;32(1):77-84, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new ferulic acid ester, 6-feruloyloxyhexanoic acid (1), was isolated along with 10 known ones (2-11), from the concentrated water extract of Rhodiola wallichiana var. cholaensis. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including Two-dimensional nuclear magnetic resonance (2D NMR) experiments. Compound 3 was isolated from this plant for the first time. The protective effects against H O -induced myocardial cell injury in cultured H9c2 cells were also evaluated. Compounds 1, 5 and 7-11 provided significant protective effects on H O -induced H9c2 cells injury at the concentration of 25 µg/mL. And the protective effects of compound 1 was also investigated by the oxygen-glucose deprivation/reperfusion (OGD/R) tests.
[Mh] Termos MeSH primário: Caproatos/farmacologia
Cardiotônicos/farmacologia
Ácidos Cumáricos/farmacologia
Rhodiola/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/farmacologia
Caproatos/administração & dosagem
Caproatos/química
Cardiotônicos/administração & dosagem
Cardiotônicos/química
Células Cultivadas
Ácidos Cumáricos/administração & dosagem
Ácidos Cumáricos/química
Relação Dose-Resposta a Droga
Ésteres/administração & dosagem
Ésteres/química
Ésteres/farmacologia
Peróxido de Hidrogênio/toxicidade
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Miócitos Cardíacos/citologia
Miócitos Cardíacos/efeitos dos fármacos
Extratos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Caproates); 0 (Cardiotonic Agents); 0 (Coumaric Acids); 0 (Esters); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335724


  2 / 3824 MEDLINE  
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[PMID]:29336154
[Au] Autor:Santiago R; López-Malvar A; Souto C; Barros-Ríos J
[Ad] Endereço:Departamento Biología Vegetal y Ciencias del Suelo, Unidad Asociada BVE1-UVIGO y Misión Biológica de Galicia (CSIC), Universidad de Vigo , Campus As Lagoas Marcosende, 36310 Vigo, Spain.
[Ti] Título:Methods for Determining Cell Wall-Bound Phenolics in Maize Stem Tissues.
[So] Source:J Agric Food Chem;66(5):1279-1284, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We compared two methods with different sample pretreatment, hydrolysis, and separation procedures to extract cell wall-bound phenolics. The samples were pith and rind tissues from six maize inbred lines reportedly containing different levels of cell wall-bound phenolics. In method 1, pretreated samples were extracted with a C solid-phase extraction cartridge, and it took 6 days to complete. In method 2, phenolics were extracted from crude samples with ethyl acetate, it took 2 days to complete, and the cost per sample was reduced more than 60%. Both methods extracted more 4-coumarate than ferulate. Overall, method 1 yielded more 4-coumarate, while method 2 yielded more ferulate. The lack of a genotype × method interaction and significant correlations between the results obtained using the two methods indicate that both methods are reliable for use in large-scale plant breeding programs. Method 2, scaled, is proposed for general plant biology research.
[Mh] Termos MeSH primário: Parede Celular/metabolismo
Fenóis/análise
Fenóis/metabolismo
Caules de Planta/química
Zea mays/química
[Mh] Termos MeSH secundário: Cruzamento
Parede Celular/química
Cromatografia Líquida de Alta Pressão
Ácidos Cumáricos/análise
Esterificação
Genótipo
Hidrólise
Propionatos/análise
Extração em Fase Sólida/métodos
Zea mays/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Phenols); 0 (Propionates); AVM951ZWST (ferulic acid); IBS9D1EU3J (trans-3-(4'-hydroxyphenyl)-2-propenoic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05752


  3 / 3824 MEDLINE  
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[PMID]:29037702
[Au] Autor:Benbettaïeb N; Tanner C; Cayot P; Karbowiak T; Debeaufort F
[Ad] Endereço:Univ. Bourgogne Franche-Comté/Agrosup Dijon, UMR PAM A02-102, Food and Wine Physical-Chemistry Lab, 1 esplanade Erasme, 21000 Dijon, France; IUT-Dijon-Auxerre, Dpt BioEngineering, 7 blvd Docteur Petitjean, 20178 Dijon Cedex, France.
[Ti] Título:Impact of functional properties and release kinetics on antioxidant activity of biopolymer active films and coatings.
[So] Source:Food Chem;242:369-377, 2018 Mar 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work deals with the study of the release kinetics of some natural antioxidants (ferulic acid, caffeic acid and tyrosol) from chitosan-fish gelatin edible films immersed ethanol at 96%, as well as the kinetics of their antioxidant activity using the DPPH assay. The aim was to determine how film functional properties influence the release kinetic and antioxidant activity. The addition of antioxidants to chitosan-fish gelatin matrix decreased the water vapour permeability by more than 30%. The tensile strength (TS) increased up to 50% after the incorporation of antioxidants. Some molecular interactions between polymer chains and antioxidants were confirmed by FTIR where spectra displayed a shift of the amide-III peak. Films containing caffeic acid or a caffeic-ferulic acid mixture exhibited the highest radical scavenging activity, leading to a 90% antioxidant activity at equilibrium but the release rate controlled the efficacy of the system.
[Mh] Termos MeSH primário: Antioxidantes/análise
Biopolímeros/química
Quitosana/química
Gelatina/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Ácidos Cafeicos/análise
Ácidos Cafeicos/química
Ácidos Cumáricos/análise
Ácidos Cumáricos/química
Produtos Pesqueiros
Cinética
Permeabilidade
Álcool Feniletílico/análogos & derivados
Álcool Feniletílico/análise
Álcool Feniletílico/química
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biopolymers); 0 (Caffeic Acids); 0 (Coumaric Acids); 1AK4MU3SNX (4-hydroxyphenylethanol); 9000-70-8 (Gelatin); 9012-76-4 (Chitosan); AVM951ZWST (ferulic acid); ML9LGA7468 (Phenylethyl Alcohol); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE


  4 / 3824 MEDLINE  
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[PMID]:29198862
[Au] Autor:Sall C; Ayé M; Bottzeck O; Praud A; Blache Y
[Ad] Endereço:Laboratoire de chimie, UFR des Sciences de la Santé, Université de Thiès, BP 967 Thiès, Senegal.
[Ti] Título:Towards smart biocide-free anti-biofilm strategies: Click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria.
[So] Source:Bioorg Med Chem Lett;28(2):155-159, 2018 01 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 = 11 µM) without toxic effect on bacterial growth even at high concentrations(100 µM).
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Biofilmes/efeitos dos fármacos
Ácidos Cumáricos/farmacologia
Paracoccus/efeitos dos fármacos
Pseudoalteromonas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Ácidos Cumáricos/síntese química
Ácidos Cumáricos/química
Relação Dose-Resposta a Droga
Testes de Sensibilidade Microbiana
Estrutura Molecular
Paracoccus/crescimento & desenvolvimento
Pseudoalteromonas/crescimento & desenvolvimento
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coumaric Acids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  5 / 3824 MEDLINE  
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[PMID]:29405075
[Au] Autor:Zhu J; Yang H; Chen Y; Lin H; Li Q; Mo J; Bian Y; Pei Y; Sun H
[Ad] Endereço:a Department of Medicinal Chemistry , China Pharmaceutical University , Nanjing , China.
[Ti] Título:Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
[So] Source:J Enzyme Inhib Med Chem;33(1):496-506, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The cholinergic hypothesis has long been a "polar star" in drug discovery for Alzheimer's disease (AD), resulting in many small molecules and biological drug candidates. Most of the drugs marketed for AD are cholinergic. Herein, we report our efforts in the discovery of cholinesterases inhibitors (ChEIs) as multi-target-directed ligands. A series of tacrine-ferulic acid hybrids have been designed and synthesised. All these compounds showed potent acetyl-(AChE) and butyryl cholinesterase(BuChE) inhibition. Among them, the optimal compound 10g, was the most potent inhibitor against AChE (electrophorus electricus (eeAChE) half maximal inhibitory concentration (IC ) = 37.02 nM), it was also a strong inhibitor against BuChE (equine serum (eqBuChE) IC = 101.40 nM). Besides, it inhibited amyloid ß-protein self-aggregation by 65.49% at 25 µM. In subsequent in vivo scopolamine-induced AD models, compound 10g obviously ameliorated the cognition impairment and showed preliminary safety in hepatotoxicity evaluation. These data suggest compound 10g as a promising multifunctional agent in the drug discovery process against AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Inibidores da Colinesterase/síntese química
Inibidores da Colinesterase/farmacologia
Ácidos Cumáricos/farmacologia
Simulação de Acoplamento Molecular
Tacrina/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Doença de Alzheimer/induzido quimicamente
Peptídeos beta-Amiloides/antagonistas & inibidores
Animais
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/química
Ácidos Cumáricos/química
Relação Dose-Resposta a Droga
Electrophorus
Cavalos
Seres Humanos
Ligantes
Masculino
Camundongos
Camundongos Endogâmicos ICR
Estrutura Molecular
Fragmentos de Peptídeos/antagonistas & inibidores
Agregados Proteicos/efeitos dos fármacos
Hidrobrometo de Escopolamina
Relação Estrutura-Atividade
Tacrina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Cholinesterase Inhibitors); 0 (Coumaric Acids); 0 (Ligands); 0 (Peptide Fragments); 0 (Protein Aggregates); 0 (amyloid beta-protein (1-42)); 451IFR0GXB (Scopolamine Hydrobromide); 4VX7YNB537 (Tacrine); AVM951ZWST (ferulic acid); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1430691


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[PMID]:29199224
[Au] Autor:Suzuki R; Kan S; Sugita Y; Shirataki Y
[Ad] Endereço:Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University.
[Ti] Título:p-Coumaroyl Malate Derivatives of the Pandanus amaryllifolius Leaf and Their Isomerization.
[So] Source:Chem Pharm Bull (Tokyo);65(12):1191-1194, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A novel p-coumaroyl dimethyl malate (1) was isolated from the Pandanus amaryllifolius leaf in addition to three known analogs of p-coumaroyl dimethyl malate (2-4), and their structures were elucidated by analysis of the spectroscopic data. The p-coumaroyl malate derivatives were isolated as a mixture of E and Z isomers. To determine the cause of isomerization, the p-coumaroyl malate isolated in this study was synthesized. We concluded that the Z isomer might be an artifact generated from the E isomer through purification steps.
[Mh] Termos MeSH primário: Ácidos Cumáricos/química
Malatos/química
Pandanaceae/química
[Mh] Termos MeSH secundário: Ácidos Cumáricos/síntese química
Ácidos Cumáricos/isolamento & purificação
Espectroscopia de Ressonância Magnética
Malatos/síntese química
Malatos/isolamento & purificação
Conformação Molecular
Pandanaceae/metabolismo
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Malates); 0 (Plant Extracts); 0 (p-coumaroylmalic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00604


  7 / 3824 MEDLINE  
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[PMID]:29196052
[Au] Autor:Hassanzadeh P; Arbabi E; Atyabi F; Dinarvand R
[Ad] Endereço:Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: p-hassanzadeh@razi.tums.ac.ir.
[Ti] Título:Ferulic acid-loaded nanostructured lipid carriers: A promising nanoformulation against the ischemic neural injuries.
[So] Source:Life Sci;193:64-76, 2018 Jan 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. MAIN METHODS: FA-NLCs were prepared by high-pressure homogenization followed by physicochemical characterization, evaluation of the bioactivity of FA-NLCs in oxygen-glucose deprivation (OGD) and global cerebral ischemia/reperfusion (I/R) injury and implication of phosphatidylinositol 3-kinase (PI3K) pathway in this regard. KEY FINDINGS: Formation of FA-NLCs which exhibited a controlled release profile, was confirmed by scanning electron microscope and differential scanning calorimetry. 1- and 8-h OGD followed by 24h re-oxygenation significantly reduced PC12 cell viability, increased lactate dehydrogenase activity and number of condensed nuclei, and induced oxidative stress as revealed by increased malondialdehyde and decreased glutathione content and superoxide dismutase and catalase activities. FA (80 and 100µM) reduced the cytotoxicity, oxidative stress, and cellular damage only after 1-h OGD, while, FA-NLCs (containing 80 and 100µM of FA) were effective at both time points. Intravenous injections of FA-NLCs (20 and 25mg/kg) into rats significantly attenuated I/R-induced neurobehavioural deficits, cellular damage, and oxidative stress, while, FA failed. Pre-treatment with PI3K inhibitor, LY294002, abolished the protective effects against OGD or I/R. SIGNIFICANCE: FA-NLCs by improving the pharmacological profile of FA and activating PI3K pathway might be of therapeutic value in cerebral stroke.
[Mh] Termos MeSH primário: Isquemia Encefálica/tratamento farmacológico
Ácidos Cumáricos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Isquemia Encefálica/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Modelos Animais de Doenças
Glucose/metabolismo
Lipídeos/uso terapêutico
Masculino
Nanoestruturas/uso terapêutico
Fármacos Neuroprotetores/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Oxigênio/metabolismo
Células PC12
Fosfatidilinositol 3-Quinase/efeitos dos fármacos
Fosfatidilinositol 3-Quinase/metabolismo
Ratos
Ratos Wistar
Traumatismo por Reperfusão
Acidente Vascular Cerebral
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Lipids); 0 (Neuroprotective Agents); AVM951ZWST (ferulic acid); EC 1.15.1.1 (Superoxide Dismutase); EC 2.7.1.137 (Phosphatidylinositol 3-Kinase); IY9XDZ35W2 (Glucose); S88TT14065 (Oxygen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


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[PMID]:28460278
[Au] Autor:Kamireddy K; Matam P; P S P; Parvatam G
[Ad] Endereço:Academy of Scientific and Innovative Research (CSIR-CFTRI campus, Mysore), India; Plant Cell Biotechnology Department, CSIR-CFTRI, Mysore-570020, India.
[Ti] Título:Biochemical characterization of a key step involved in 2H4MB production in Decalepis hamiltonii.
[So] Source:J Plant Physiol;214:74-80, 2017 Jul.
[Is] ISSN:1618-1328
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Decalepis hamiltonii is widely known for its flavour molecule 2-Hydroxy-4-Methoxy Benzaldehyde (2H4MB), a structural isomer of vanillin. As the biosynthetic pathway of 2H4MB is not known, we hypothesised 2H4MB origins could be from phenylpropanoid pathway (PPP). Accordingly, a study was conducted using PPP inhibitors (viz. piperonylic acid, MDCA and propanil) against in vitro root cultures of D. hamiltonii to find the branch of PPP which catalyses the 2H4MB formation. HPLC analysis was carried out to quantify 2H4MB levels in control and respective inhibitor treated root cultures in vitro. The results obtained revealed that piperonylic acid did not inhibit 2H4MB biosynthesis in the given period, whereas MDCA and propanil had the marked inhibitory effect. The inhibitory effect was evident with 13.2, 33.6 and 37.9% decrease in 2H4MB levels at 50, 100 and 150mM concentration of MDCA respectively in comparison with control roots. Similarly, the inhibitory effect of propanil on 2H4MB biosynthesis was obvious with 23.7, 49.5 and 57.9% decrease in 2H4MB levels at 50, 100 and 150µM concentration of inhibitor respectively when compared with control roots. Propanil showed a greater slow down effect on 2H4MB biosynthesis compared to MDCA. Incorporation of 0.1, 0.5 and 1.0mM ferulic acid as a precursor to in vitro root cultures of D. hamiltonii showed an increase in 2H4MB levels at the rate of 3.1, 107 and 94.1% respectively as quantified by HPLC analysis. However, ferulic acid in conjunction with propanil did not show any increase in 2H4MB levels. This clearly explains that ferulic acid is channelled through the 4-CL (4-coumarate CoA ligase) enzyme, where it would be converted to feruloyl-CoA and could be further converted to 2H4MB in D. hamiltonii.
[Mh] Termos MeSH primário: Apocynaceae/metabolismo
Extratos Vegetais/metabolismo
[Mh] Termos MeSH secundário: Benzaldeídos/metabolismo
Benzoatos/metabolismo
Ácidos Cumáricos/metabolismo
Fenilpropionatos/metabolismo
Raízes de Plantas/metabolismo
Propanil/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Benzoates); 0 (Coumaric Acids); 0 (Phenylpropionates); 0 (Plant Extracts); 0 (phenylpropanoid 3,4-(methylenedioxy)cinnamic acid); 709-98-8 (Propanil); AVM951ZWST (ferulic acid); QX3V1NO0KH (piperonylic acid); TA269SD04T (benzaldehyde)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  9 / 3824 MEDLINE  
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[PMID]:29190278
[Au] Autor:Rechner O; Neugart S; Schreiner M; Wu S; Poehling HM
[Ad] Endereço:Section of Phytomedicine, Institute of Horticultural Production Systems, Hannover, Germany.
[Ti] Título:Can narrow-bandwidth light from UV-A to green alter secondary plant metabolism and increase Brassica plant defenses against aphids?
[So] Source:PLoS One;12(11):e0188522, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Light of different wavelengths is essential for plant growth and development. Short-wavelength radiation such as UV can shift the composition of flavonoids, glucosinolates, and other plant metabolites responsible for enhanced defense against certain herbivorous insects. The intensity of light-induced, metabolite-based resistance is plant- and insect species-specific and depends on herbivore feeding guild and specialization. The increasing use of light-emitting diodes (LEDs) in horticultural plant production systems in protected environments enables the creation of tailor-made light scenarios for improved plant cultivation and induced defense against herbivorous insects. In this study, broccoli (Brassica oleracea var. italica) plants were grown in a climate chamber under broad spectra photosynthetic active radiation (PAR) and were additionally treated with the following narrow-bandwidth light generated with LEDs: UV-A (365 nm), violet (420 nm), blue (470 nm), or green (515 nm). We determined the influence of narrow-bandwidth light on broccoli plant growth, secondary plant metabolism (flavonol glycosides and glucosinolates), and plant-mediated light effects on the performance and behavior of the specialized cabbage aphid Brevicoryne brassicae. Green light increased plant height more than UV-A, violet, or blue LED treatments. Among flavonol glycosides, specific quercetin and kaempferol glycosides were increased under violet light. The concentration of 3-indolylmethyl glucosinolate in plants was increased by UV-A treatment. B. brassicae performance was not influenced by the different light qualities, but in host-choice tests, B. brassicae preferred previously blue-illuminated plants (but not UV-A-, violet-, or green-illuminated plants) over control plants.
[Mh] Termos MeSH primário: Afídeos/fisiologia
Brassica/metabolismo
Raios Ultravioleta
[Mh] Termos MeSH secundário: Animais
Brassica/imunologia
Ácidos Cumáricos/metabolismo
Glucosinolatos/metabolismo
Interações Hospedeiro-Parasita
Indóis/metabolismo
Quempferóis/metabolismo
Folhas de Planta
Quercetina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumaric Acids); 0 (Glucosinolates); 0 (Indoles); 0 (Kaempferols); 731P2LE49E (kaempferol); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188522


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[PMID]:27772541
[Au] Autor:Zhang Q; Chen ZW; Zhao YH; Liu BW; Liu NW; Ke CC; Tan HM
[Ti] Título:Bone Marrow Stromal Cells Combined With Sodium Ferulate and -Butylidenephthalide Promote the Effect of Therapeutic Angiogenesis via Advancing Astrocyte-Derived Trophic Factors After Ischemic Stroke.
[So] Source:Cell Transplant;26(2):229-242, 2017 Feb 16.
[Is] ISSN:1555-3892
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Being a potential candidate for stroke treatment, bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) have been demonstrated to be able to enhance angiogenesis and proliferation of reactive astrocytes, which subsequently leads to the amelioration of neurological injury. Increasing evidence further indicates that combining BM-MSCs with certain agents, such as simvastatin, may improve therapeutic effects. Sodium ferulate (SF) and n-butylidenephthalide (BP), two main components of Radix Angelica Sinensis, are proven to be important regulators of stem cells in cell migration, differentiation, and pluripotency maintenance. This study aimed to investigate whether combining BM-MSCs with SF and BP had better therapeutic effect in the treatment of stroke, and the underlying molecular basis for the therapeutic effects was also investigated. The results showed that combination treatment notably reduced neurological injury after stroke and increased the expression of astrocyte-derived vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and von Willebrand factor-positive vascular density in the ischemic boundary zone as evaluated by immunofluorescence staining. After treatment with BM-MSCs plus SF and BP, astrocytes showed increased expression of VEGF and BDNF by upregulating protein kinase B/mammalian target of rapamycin (AKT/mTOR) expression in an oxygen- and glucose-deprived (OGD) environment. Human umbilical vein endothelial cells (HUVECs) incubated with the conditioned medium (CM) derived from OGD astrocytes treated with BM-MSCs plus SF and BP showed significantly increased migration and tube formation compared with those incubated with the CM derived from OGD astrocytes treated with BM-MSCs alone. These results demonstrate that combination treatment enhances the expression of astrocyte-derived VEGF and BDNF, which contribute to angiogenesis after cerebral ischemia, and the underlying mechanism is associated with activation of the astrocytic AKT/mTOR signaling pathway. Our study provides a potential therapeutic approach for ischemic stroke.
[Mh] Termos MeSH primário: Células da Medula Óssea/citologia
Isquemia Encefálica/terapia
Ácidos Cumáricos/farmacologia
Células Mesenquimais Estromais/fisiologia
Anidridos Ftálicos/farmacologia
Acidente Vascular Cerebral/terapia
[Mh] Termos MeSH secundário: Animais
Astrócitos/citologia
Astrócitos/efeitos dos fármacos
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Células Cultivadas
Imunofluorescência
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Masculino
Células Mesenquimais Estromais/citologia
Neovascularização Fisiológica/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-akt/metabolismo
Ratos
Ratos Sprague-Dawley
Serina-Treonina Quinases TOR/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
Cicatrização/efeitos dos fármacos
Fator de von Willebrand/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Coumaric Acids); 0 (Phthalic Anhydrides); 0 (Vascular Endothelial Growth Factor A); 0 (brain-derived neurotrophic factor, human); 0 (von Willebrand Factor); AVM951ZWST (ferulic acid); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); S9178G4B3F (butylidenephthalide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.3727/096368916X693536



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