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[PMID]:28466135
[Au] Autor:da Silveira TFF; Meinhart AD; de Souza TCL; Cunha ECE; de Moraes MR; Filho JT; Godoy HT
[Ad] Endereço:School of Food Engineering, State University of Campinas (UNICAMP), Campinas, SP, Brazil. ferreira.tayse@gmail.com.
[Ti] Título:Optimization of the Preparation Conditions of Yerba Mate tea Beverage to Maximize Chlorogenic Acids Extraction.
[So] Source:Plant Foods Hum Nutr;72(2):219-223, 2017 Jun.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The beverage obtained from the yerba mate tea, besides being the most consumed in Brazil, has high concentrations of chlorogenic acids. In this study, a central composite design was employed to establish the best infusion time, temperature and water volume to maximize the extraction of chlorogenic acids 5-caffeoylquinic (5CQ), 3.4-dicaffeoylquinic (3.4 DQ), 3.5-dicaffeoylquinic (3.5 DQ) and 4.5-dicaffeoylquinic (4.5 DQ), from the leaves and stems of yerba mate tea (beverage ready for consumption). Analyses were performed by high-performance liquid chromatography and the optimum conditions were obtained through the use of the desirability function of Derringer and Suich. The maximum chlorogenic acids content in the beverage was obtained when the infusion was prepared with 2 g of mate tea, in 300 mL of water at 95 °C, under infusion for 16 min. The optimal conditions were applied for the preparation of beverages from 15 commercial samples of yerba mate tea, and it was observed that the sum of the concentration of the four compounds showed variation of up to 79 times between the average of the samples, which can be attributed to climatic conditions of cultivation of the plant and/or of processing.
[Mh] Termos MeSH primário: Ácido Clorogênico/isolamento & purificação
Ilex paraguariensis/química
Ácido Quínico/análogos & derivados
[Mh] Termos MeSH secundário: Brasil
Ácido Clorogênico/análise
Cromatografia Líquida de Alta Pressão
Metanol
Folhas de Planta/química
Caules de Planta/química
Ácido Quínico/análise
Ácido Quínico/isolamento & purificação
Chás de Ervas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Teas, Herbal); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid); 318ADP12RI (Chlorogenic Acid); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-017-0613-6


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[PMID]:28796787
[Au] Autor:He H; Weir RL; Toutounchian JJ; Pagadala J; Steinle JJ; Baudry J; Miller DD; Yates CR
[Ad] Endereço:Department of Pharmaceutical Sciences, UTHSC College of Pharmacy, Memphis, Tennessee, United States of America.
[Ti] Título:The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism.
[So] Source:PLoS One;12(8):e0180808, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Retinal microaneurysms, an early disease manifestation of diabetic retinopathy, are associated with retinal endothelial cell (REC) death and macular edema. We previously demonstrated that a quinic acid (QA) analog, KZ-41, promoted REC survival by blunting stress-induced p38 MAPK activation. Herein, we sought to expand our understanding of the pro-survival signal transduction pathways actuated by KZ-41. Using human RECs exposed to high glucose (25 mM, 72 hours), we demonstrated that KZ-41 blocks caspase-3 activation by triggering phosphorylation of the PI3K regulatory subunit (p85; Tyr458) and its downstream target Akt (Ser473). Akt signal transduction was accompanied by autophosphorylation of the receptor tyrosine kinase, insulin growth factor-1 receptor (IGF-1R). IGF-1R knockdown using either the tyrosine kinase inhibitor AG1024 or silencing RNA abolished KZ-41's pro-survival effect. Under high glucose stress, caspase-3 activation correlated with elevated ERK1/2 phosphorylation and decreased insulin receptor substrate-1 (IRS-1) levels. KZ-41 decreased ERK1/2 phosphorylation and reversed the glucose-dependent reduction in IRS-1. To gain insight into the mechanistic basis for IGF-1R activation by KZ-41, we used molecular modeling and docking simulations to explore a possible protein:ligand interaction between the IGF-1R kinase domain and KZ-41. Computational investigations suggest two possible KZ-41 binding sites within the kinase domain: a region with high homology to the insulin receptor contains one potential allosteric binding site, and another potential site on the other side of the kinase domain, near the hinge domain. These data, together with previous proof-of-concept efficacy studies demonstrating KZ-41 mitigates pathologic retinal neovascularization in the murine oxygen-induced retinopathy model, suggests that QA derivatives may offer therapeutic benefit in ischemic retinopathies.
[Mh] Termos MeSH primário: Caspase 3/metabolismo
Células Endoteliais/efeitos dos fármacos
Ativação Enzimática/efeitos dos fármacos
Glucose/metabolismo
Ácido Quínico/análogos & derivados
Receptor IGF Tipo 1/metabolismo
Retina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células Cultivadas
Retinopatia Diabética/tratamento farmacológico
Retinopatia Diabética/metabolismo
Células Endoteliais/citologia
Células Endoteliais/metabolismo
Seres Humanos
Simulação de Acoplamento Molecular
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Ácido Quínico/química
Ácido Quínico/farmacologia
Retina/citologia
Retina/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KZ 41 compound); 058C04BGYI (Quinic Acid); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.10.1 (Receptor, IGF Type 1); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.22.- (Caspase 3); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180808


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[PMID]:28763758
[Au] Autor:Wang Y; Wang Y; Wu X; Xiong Z; Xiao W; Ma C
[Ad] Endereço:School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
[Ti] Título:Simultaneous determination of three di-caffeoylquinic acids by UHPLC-MS/MS in rat plasma and its application to a comparative pharmacokinetic study in normal and acute lung injury rat.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1061-1062:275-281, 2017 Sep 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Acute lung injury (ALI) is a severe inflammatory disease with high mortality rates. Di-caffeoylquinic acids (DCQAs), the bioactive components of reduning injection (RDN), may play important roles in the protective effect on acute lung injury (ALI). A selective and rapid ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method has been developed and validated for the simultaneous determination of 3,4-, 3,5- and 4,5-DCQA in rat plasma. The DCQAs were extracted by liquid-liquid extraction with ethyl acetate-isopropyl alcohol (7:3, v/v). Chromatographic separation was accomplished on a C18 column using gradient elution. Detection was performed in the multiple reaction monitoring (MRM) mode. The lower limits of quantification were all 2.0ng/mL for the three analytes. Intra-day and inter-day precision were less than 15% and accuracy ranged from -13.8% to 10.0%, and the mean extraction recoveries of analytes from rat plasma were all more than 72.9%. Meanwhile, this method had been successfully applied to compare the pharmacokinetics of the three DCQAs in normal and ALI model rat after RDN was given intravenously administration. The pharmacokinetic parameters of the 3,4-, 3,5- and 4,5- DCQA were remarkably different from those in normal rats. It might result from the effects of the pathological status of ALI. This study presented a meaningful basis for the clinical applications of RDN when used in the treatment of ALI.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/metabolismo
Cromatografia Líquida de Alta Pressão/métodos
Ácido Quínico/análogos & derivados
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/farmacocinética
Limite de Detecção
Modelos Lineares
Masculino
Ácido Quínico/sangue
Ácido Quínico/química
Ácido Quínico/farmacocinética
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (caffeoylquinic acid); 0 (reduning); 058C04BGYI (Quinic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE


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Bastos, Jairo Kenupp
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[PMID]:28756355
[Au] Autor:Motta EVDS; da Costa JC; Bastos JK
[Ad] Endereço:School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
[Ti] Título:A validated HPLC-UV method for the analysis of galloylquinic acid derivatives and flavonoids in Copaifera langsdorffii leaves.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1061-1062:240-247, 2017 Sep 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Copaifera langsdorffii Desf. (Fabaceae, Caesalpinioideae), popularly known as "copaiba" or "pau d'óleo", is a species of tree that is found throughout Brazil. The leaves of this tree are used in folk medicine to treat kidney stones. Galloylquinic acid derivatives and flavonoids are the main secondary metabolites found in C. langsdorffii leaves and are likely to be responsible for the effectiveness of this treatment. As an attempt to produce a phytotherapic, we have developed a reliable HPLC-UV method for the quality control of C. langsdorffii leaves. Phenolic compounds were extracted from C. langsdorffii leaves using 70% aqueous ethanol as the extraction solvent. HPLC-UV analyses were carried out on a Synergi Polar-RP column (100×3.0mm, 2.5µm), and the mobile phase was made up of formic acid-water (0.1:99.9, solvent A), and isopropanol-methanol-acetonitrile (5:40:60, solvent B). The elution gradient was A:B (90:10 to 85:15) in 8.0min, followed by A:B (85:15 to 64:36) up to 30.0min, using a flow rate of 0.7mL/min, and UV detection at 280nm. This method was used to quantify nine galloylquinic acid derivatives and two flavonoids, which gave a good detection response and linearity in the range of 1.88-110.0µg/mL. Furthermore, the detection and quantification limits ranged from 0.070 to 0.752µg/mL, and 0.211-2.278µg/mL respectively, with a maximum RSD of 4.18%. The method is reliable for the quality control of C. langsdorffii raw material, its hydroethanolic extract, and could potentially be used to quantify these compounds in other Copaifera species.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Fabaceae/química
Flavonoides/análise
Extratos Vegetais/química
Ácido Quínico/análise
[Mh] Termos MeSH secundário: Flavonoides/química
Limite de Detecção
Modelos Lineares
Folhas de Planta/química
Ácido Quínico/análogos & derivados
Ácido Quínico/química
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 058C04BGYI (Quinic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE


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[PMID]:28755585
[Au] Autor:Spínola V; Castilho PC
[Ad] Endereço:CQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
[Ti] Título:Evaluation of Asteraceae herbal extracts in the management of diabetes and obesity. Contribution of caffeoylquinic acids on the inhibition of digestive enzymes activity and formation of advanced glycation end-products (in vitro).
[So] Source:Phytochemistry;143:29-35, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The study was performed to assess, for the first time, the in vitro anti-diabetic potential of ten Asteraceae plant extracts to inhibit the activity of digestive enzymes (α-amylase, α-, ß-glucosidases and lipase) responsible for hydrolysis/digestion of sugar and lipids. Prevention of advanced glycation end-products (AGEs) formation was evaluated in bovine serum albumin/ribose glycation reaction model. The phytochemical profiles and caffeoylquinic acids (CQAs) contents were determined for the methanolic extract of each plant. Analyzed plant extracts exhibited significant inhibitory activity against key digestive enzymes linked to type II diabetes and obesity. A strong inhibition was observed for glucosidases and mild activity towards amylase and lipase (compared to reference compounds). Moreover, some extracts exhibited potent ability to prevent formation of AGEs, implicated in some diabetic complications. Caffeoylquinic acids were dominant in all plant extracts and findings demonstrate that these compounds are the most relevant hypoglycemic and anti-glycation agents. From the obtained results, Argyranthemum pinnatifidum, Helichrysum melaleucum, and Phagnalon lowei are good candidates for further development of phyto-pharmaceutical preparations as complementary therapy for diabetes and obesity control.
[Mh] Termos MeSH primário: Asteraceae/metabolismo
Diabetes Mellitus Tipo 2/tratamento farmacológico
Produtos Finais de Glicação Avançada/metabolismo
Hipoglicemiantes/farmacologia
Obesidade/tratamento farmacológico
Extratos Vegetais/farmacologia
Ácido Quínico/análogos & derivados
[Mh] Termos MeSH secundário: Antioxidantes/química
Diabetes Mellitus Tipo 2/prevenção & controle
Obesidade/prevenção & controle
Fitoterapia
Ácido Quínico/farmacologia
alfa-Amilases/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glycation End Products, Advanced); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170730
[St] Status:MEDLINE


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[PMID]:28623927
[Au] Autor:Jiang Y; Lin Y; Hu YJ; Song XJ; Pan HH; Zhang HJ
[Ad] Endereço:Dispensary of Traditional Chinese Medicine, Hangzhou First People's Hospital, 261 Huansha Road, Hangzhou, 310006, China.
[Ti] Título:Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.
[So] Source:BMC Complement Altern Med;17(1):320, 2017 Jun 17.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. METHODS: G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model. RESULTS: G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia. The extract of G. pensylvanicum also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, 13 caffeoylquinic acid derivatives and 1 flavone were identified by UPLC-ESI-MS/MS as the main active component of G. pensylvanicum. CONCLUSIONS: The extract of G. pensylvanicum showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Artrite Gotosa/tratamento farmacológico
Gnaphalium/química
Supressores da Gota/administração & dosagem
Hiperuricemia/tratamento farmacológico
Extratos Vegetais/administração & dosagem
Ácido Quínico/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Artrite Gotosa/imunologia
Modelos Animais de Doenças
Proteínas Facilitadoras de Transporte de Glucose/genética
Proteínas Facilitadoras de Transporte de Glucose/metabolismo
Supressores da Gota/química
Seres Humanos
Hiperuricemia/genética
Hiperuricemia/imunologia
Rim/efeitos dos fármacos
Rim/metabolismo
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/química
Ácido Quínico/administração & dosagem
Ácido Quínico/química
Ácido Úrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Glucose Transport Proteins, Facilitative); 0 (Gout Suppressants); 0 (Plant Extracts); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid); 268B43MJ25 (Uric Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1834-9


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[PMID]:28622119
[Au] Autor:Shiono T; Yamamoto K; Yotsumoto Y; Yoshida A
[Ad] Endereço:a Research Laboratories for Beverage Technologies, Research & Development Division , Kirin Company, Ltd. , Yokohama , Japan.
[Ti] Título:Caffeine adsorption of montmorillonite in coffee extracts.
[So] Source:Biosci Biotechnol Biochem;81(8):1591-1597, 2017 Aug.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The growth in health-conscious consumers continues to drive the demand for a wide variety of decaffeinated beverages. We previously developed a new technology using montmorillonite (MMT) in selective decaffeination of tea extract. This study evaluated and compared decaffeination of coffee extract using MMT and activated carbon (AC). MMT adsorbed caffeine without significant adsorption of caffeoylquinic acids (CQAs), feruloylquinic acids (FQAs), dicaffeoylquinic acids (di-CQAs), or caffeoylquinic lactones (CQLs). AC adsorbed caffeine, chlorogenic acids (CGAs) and CQLs simultaneously. The results suggested that the adsorption selectivity for caffeine in coffee extract is higher in MMT than AC. The caffeine adsorption isotherms of MMT in coffee extract fitted well to the Langmuir adsorption model. The adsorption properties in coffee extracts from the same species were comparable, regardless of roasting level and locality of growth. Our findings suggest that MMT is a useful adsorbent in the decaffeination of a wide range of coffee extracts.
[Mh] Termos MeSH primário: Bentonita/química
Cafeína/isolamento & purificação
Coffea/química
Café/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Adsorção
Carvão Vegetal/química
Ácidos Cumáricos/química
Cinética
Lactonas/química
Ácido Quínico/análogos & derivados
Ácido Quínico/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,3-di-O-feruloylquinic acid); 0 (Coffee); 0 (Coumaric Acids); 0 (Lactones); 0 (Plant Extracts); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid); 1302-78-9 (Bentonite); 16291-96-6 (Charcoal); 3G6A5W338E (Caffeine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1340087


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[PMID]:28441769
[Au] Autor:Surjadinata BB; Jacobo-Velázquez DA; Cisneros-Zevallos L
[Ad] Endereço:Department of Horticultural Sciences, Texas A&M University, College Station, TX 778432-133, USA. Bernadeth_Surjadinata@bayvalleyfoods.com.
[Ti] Título:UVA, UVB and UVC Light Enhances the Biosynthesis of Phenolic Antioxidants in Fresh-Cut Carrot through a Synergistic Effect with Wounding.
[So] Source:Molecules;22(4), 2017 Apr 24.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Previously, we found that phenolic content and antioxidant capacity (AOX) in carrots increased with wounding intensity. It was also reported that UV radiation may trigger the phenylpropanoid metabolism in plant tissues. Here, we determined the combined effect of wounding intensity and UV radiation on phenolic compounds, AOX, and the phenylalanine ammonia-lyase (PAL) activity of carrots. Accordingly, phenolic content, AOX, and PAL activity increased in cut carrots with the duration of UVC radiation, whereas whole carrots showed no increase. Carrot pies showed a higher increase compared to slices and shreds. Phenolics, AOX, and PAL activity also increased in cut carrots exposed to UVA or UVB. The major phenolics were chlorogenic acid and its isomers, ferulic acid, and isocoumarin. The type of UV radiation affected phenolic profiles. Chlorogenic acid was induced by all UV radiations but mostly by UVB and UVC, ferulic acid was induced by all UV lights to comparable levels, while isocoumarin and 4,5-diCQA was induced mainly by UVB and UVC compared to UVA. In general, total phenolics correlated linearly with AOX for all treatments. A reactive oxygen species (ROS) mediated hypothetical mechanism explaining the synergistic effect of wounding and different UV radiation stresses on phenolics accumulation in plants is herein proposed.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Daucus carota/metabolismo
[Mh] Termos MeSH secundário: Vias Biossintéticas/efeitos da radiação
Ácido Clorogênico/metabolismo
Culinária
Ácidos Cumáricos/metabolismo
Daucus carota/efeitos da radiação
Isocumarinas/metabolismo
Ácido Quínico/análogos & derivados
Ácido Quínico/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Coumaric Acids); 0 (Isocoumarins); 0 (Reactive Oxygen Species); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid); 318ADP12RI (Chlorogenic Acid); AVM951ZWST (ferulic acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28420230
[Au] Autor:Abrankó L; Clifford MN
[Ad] Endereço:Faculty of Food Science, Department of Applied Chemistry, Szent István University , 1118 Budapest, Hungary.
[Ti] Título:An Unambiguous Nomenclature for the Acyl-quinic Acids Commonly Known as Chlorogenic Acids.
[So] Source:J Agric Food Chem;65(18):3602-3608, 2017 May 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The history of the acyl-quinic acids is briefly reviewed, the merits and limitations of the various nomenclature systems applicable are critically compared, and their limitations are highlighted, in particular their inability to provide an unambiguous description of all quinic acid enantiomers and diastereoisomers and associated acyl-quinic acids. Recommendations are made for a nomenclature system that in combination with IUPAC numbering achieves this objective. A comprehensive set of structures for the quinic acid enantiomers and diastereoisomers is presented. The Supporting Information provides an explanation of trivial names and a decision tree to determine which quinic acid isomer a structure represents.
[Mh] Termos MeSH primário: Ácido Clorogênico/química
Ácido Quínico/química
[Mh] Termos MeSH secundário: Isomerismo
Estrutura Molecular
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
058C04BGYI (Quinic Acid); 318ADP12RI (Chlorogenic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00729


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[PMID]:28245635
[Au] Autor:Santana-Gálvez J; Cisneros-Zevallos L; Jacobo-Velázquez DA
[Ad] Endereço:Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Av. Eugenio Garza Sada 2501 Sur, C.P. 64849 Monterrey, Mexico. jsantanag2000@gmail.com.
[Ti] Título:Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome.
[So] Source:Molecules;22(3), 2017 Feb 26.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from thehydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, mostof them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory,antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discussthe role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolicsyndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms ofaction. The second part of the review will be dealing with the role of chlorogenic acid as a foodadditive. Chlorogenic acid has shown antimicrobial activity against a wide range of organisms,including bacteria, yeasts, molds, viruses, and amoebas. These antimicrobial properties can beuseful for the food industry in its constant search for new and natural molecules for thepreservation of food products. In addition, chlorogenic acid has antioxidant activity, particularlyagainst lipid oxidation; protective properties against degradation of other bioactive compoundspresent in food, and prebiotic activity. The combination of these properties makes chlorogenic acidan excellent candidate for the formulation of dietary supplements and functional foods.
[Mh] Termos MeSH primário: Ácido Clorogênico/análogos & derivados
Ácido Clorogênico/administração & dosagem
Aditivos Alimentares/administração & dosagem
Síndrome Metabólica/dietoterapia
Ácido Quínico/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Ácido Clorogênico/uso terapêutico
Ensaios Clínicos como Assunto
Suplementos Nutricionais
Modelos Animais de Doenças
Aditivos Alimentares/uso terapêutico
Seres Humanos
Síndrome Metabólica/prevenção & controle
Ácido Quínico/administração & dosagem
Ácido Quínico/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Food Additives); 058C04BGYI (Quinic Acid); 318ADP12RI (Chlorogenic Acid); O4601UER1Z (5'-O-caffeoylquinic acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE



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