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[PMID]:28471102
[Au] Autor:Yoo SG; Cho MJ; Kim US; Baek SH
[Ad] Endereço:Department of Ophthalmology, Kim's Eye Hospital, Seoul, Korea.
[Ti] Título:Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen.
[So] Source:Korean J Ophthalmol;31(3):249-256, 2017 Jun.
[Is] ISSN:2092-9382
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effectiveness of a cycloplegic regimen using 0.5% tropicamide and 0.5% phenylephrine (Tropherine, Hanmi Pharm), in addition to 1% cyclopentolate, in hyperopic children. METHODS: The medical records of hyperopic patients below the age of 14 years who had undergone cycloplegic retinoscopy were retrospectively reviewed. Cycloplegic refractions were performed using one of two cycloplegic regimens. Regimen 1 was a Tropherine-added regimen comprising the administration of one drop of 1% cyclopentolate followed by two to three drops of Tropherine added at 15-minute intervals. Regimen 2 was a cyclopentolate-only regimen comprising the administration of three to four drops of 1% cyclopentolate at 15-minute intervals. The mean difference between noncycloplegic and cycloplegic refraction was compared between the two regimens. RESULTS: A total of 308 eyes of 308 hyperopic children were included. The mean difference (±standard deviation) in the spherical equivalent (SE) between cycloplegic and noncycloplegic refraction was significantly larger in regimen 2 than in regimen 1, with values of +1.70 ± 1.03 diopters (D) and +1.25 ± 0.89 D, respectively (p=0.001). The SE change after cycloplegia was significantly different between the two regimens only in patients aged 5 years or younger (p=0.001), particularly in those with high hyperopia with an SE ≥5 D (p=0.005) or fully accommodative esotropia (p=0.009). There was no significant difference between the two regimens in patients older than 5 years, regardless of the presence of high hyperopia or fully accommodative esotropia. CONCLUSIONS: The Tropherine-added regimen exerted a weaker cycloplegic effect than the cyclopentolate-only regimen, particularly in children under the age of 5 years with high hyperopia or fully accommodative esotropia. However, the difference in refraction between the two regimens was small. A Tropherine-added regimen can be effective in hyperopic children, with less associated discomfort than the instillation of cyclopentolate.
[Mh] Termos MeSH primário: Acomodação Ocular/efeitos dos fármacos
Ciclopentolato/administração & dosagem
Oftalmopatias Hereditárias/tratamento farmacológico
Hiperopia/tratamento farmacológico
Fenilefrina/administração & dosagem
Refração Ocular/efeitos dos fármacos
Tropicamida/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Quimioterapia Combinada
Oftalmopatias Hereditárias/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Hiperopia/fisiopatologia
Lactente
Recém-Nascido
Masculino
Midriáticos/administração & dosagem
Soluções Oftálmicas/administração & dosagem
Estudos Retrospectivos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); I76F4SHP7J (Cyclopentolate); N0A3Z5XTC6 (Tropicamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.3341/kjo.2016.0007


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[PMID]:29202152
[Au] Autor:Nunn A; Sturek JM; Reuss JE; Rein MF; Heysell SK
[Ad] Endereço:Department of Pediatrics, Penn State Health Children's Hospital, Hershey, PA, USA.
[Ti] Título:Subacute loss of vision in one eye · rash on hands and feet · plaques with scaling on genitals · Dx?
[So] Source:J Fam Pract;66(12):E9-E11, 2017 Dec.
[Is] ISSN:1533-7294
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 67-year-old man presented to the hospital with subacute loss of vision in his left eye. The visual changes began 2 weeks earlier, with a central area of visual loss that had since progressed to near complete vision loss in the left eye. Physical examination revealed patchy alopecia, a scaling and hyperkeratotic rash of his hands and feet, and blanching, erythematous plaques with associated scaling on the scrotum and glans penis. Ophthalmologic examination revealed 1/200 vision in his left eye with a large plaque occupying a substantial portion of the superior quadrant, smaller perifoveal plaques in both of his eyes, and a small infiltrate above the left optic nerve head. The patient also described fatigue, loss of taste, and an unintentional weight loss of 7 to 10 kg over the previous 6 months. He had seen his primary care provider 3 months prior for a burning sensation and scaling rash on his feet and hands, and was prescribed a topical steroid.
[Mh] Termos MeSH primário: Infecções por HIV/diagnóstico
Sífilis/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/uso terapêutico
Fármacos Anti-HIV/uso terapêutico
Biópsia
Coinfecção
Ciclopentolato/uso terapêutico
Diagnóstico Diferencial
Exantema/diagnóstico
Exantema/tratamento farmacológico
Glucocorticoides/uso terapêutico
Infecções por HIV/tratamento farmacológico
Seres Humanos
Masculino
Midriáticos/uso terapêutico
Penicilinas/uso terapêutico
Prednisolona/uso terapêutico
Sífilis/tratamento farmacológico
Transtornos da Visão/diagnóstico
Transtornos da Visão/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-HIV Agents); 0 (Glucocorticoids); 0 (Mydriatics); 0 (Penicillins); 9PHQ9Y1OLM (Prednisolone); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:28503812
[Au] Autor:Lin Z; Vasudevan B; Ciuffreda KJ; Zhou HJ; Mao GY; Wang NL; Liang YB
[Ad] Endereço:School of Ophthalmology and Optometry, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.
[Ti] Título:The difference between cycloplegic and non-cycloplegic autorefraction and its association with progression of refractive error in Beijing urban children.
[So] Source:Ophthalmic Physiol Opt;37(4):489-497, 2017 Jul.
[Is] ISSN:1475-1313
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the difference between cycloplegic and non-cycloplegic autorefraction and its association with the progression of refractive error in Beijing urban children. METHODS: A total of 386 children aged 6-17 years were enrolled in the baseline investigation of the Beijing Myopia Progression Study in 2010. They were invited for follow-up vision examinations in the years 2011, 2012, and 2013, including cycloplegic (cyclopentolate 1%, three times) autorefraction. We investigated the difference between the cycloplegic spherical equivalent (SE) and the non-cycloplegic SE (DSE) provided by autorefraction and its association with refractive error progression. The progression of refractive error was defined as the difference between the cycloplegic SE at follow-up and at baseline. RESULTS: Two hundred and nineteen children (57%) with completed refractive data (mean ± standard deviation: -1.36 ± 2.44 D at baseline) were ultimately enrolled. The DSE reduced from 0.51 ± 0.72 D at baseline to 0.19 ± 0.43 D in the third year of follow-up (p = 0.01). The baseline DSE was positively associated with the children's baseline cycloplegic refraction (ß = 0.193 dioptre dioptre , p < 0.001). After further divided by refractive status, the DSE was consistently higher in the hyperopic group than in either the emmetropic or myopic groups at each follow-up (all p < 0.001). In the multivariate regression analysis, the myopic children with larger baseline DSE (ß = -0.404 dioptre dioptre , p = 0.01) exhibited more myopic refractive change. However, baseline DSE was not found to be a significant risk factor (relative risk, 95% confidence interval: 1.06, 0.79-1.41) for those with newly developed myopia. CONCLUSION: In this sample, the children's DSE was found to be increased as the hyperopic refraction increased. Furthermore, greater the DSE was associated with the progression of refractive error among the myopic children, but not with the onset of myopia.
[Mh] Termos MeSH primário: Ciclopentolato/administração & dosagem
Refração Ocular/fisiologia
Erros de Refração/fisiopatologia
População Urbana
[Mh] Termos MeSH secundário: Adolescente
Pequim/epidemiologia
Criança
Progressão da Doença
Feminino
Seguimentos
Seres Humanos
Incidência
Masculino
Midriáticos/administração & dosagem
Soluções Oftálmicas
Refração Ocular/efeitos dos fármacos
Erros de Refração/epidemiologia
Estudos Retrospectivos
Testes Visuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1111/opo.12381


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[PMID]:28118561
[Au] Autor:Rezk MR; Fayed AS; Marzouk HM; Abbas SS
[Ad] Endereço:Cairo University, Faculty of Pharmacy, Analytical Chemistry Department, El- Kasr El-Aini St, 11562 Cairo, Egypt.
[Ti] Título:Chromatographic Determination of Cyclopentolate Hydrochloride and Phenylephrine Hydrochloride in the Presence of Their Potential Degradation Products.
[So] Source:J AOAC Int;100(2):434-444, 2017 Mar 01.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two sensitive, selective, and precise stability-indicating methods have been developed for the simultaneous determination of the active pharmaceutical ingredients cyclopentolate hydrochloride (CLO) and phenylephrine hydrochloride (PHE) in their pure forms and in the presence of their degradation products. The methods were applied for the determination of CLO and PHE in a pharmaceutical formulation. Method A was based on isocratic elution HPLC determination. Separation was achieved using a Waters Spherisorb ODS2 C18 analytical column (5 µm particle size) and a mobile phase of 0.1% heptane-1-sulphonic acid sodium salt in methanol-water (80 + 20, v/v). The flow rate was 1.0 mL/min and detection was performed at 210 nm. Method B was an HPTLC- densitometric method using HPTLC silica gel 60 F254 plates and an optimized mobile phase of ethyl acetate-methanol-ammonia (8 + 2 + 0.1, v/v/v). The separated spots were densitometrically scanned at 210 nm. Polynomial equations were used for regression. The developed methods are suitable for the determination of CLO and PHE in their binary mixture and in the presence of their corresponding degradation products. The two methods were validated in compliance with International Conference on Harmonization guidelines and successfully applied for the determination of CLO and PHE as synthetically prepared in laboratory mixtures and in the presence of their possible degradation products. CLO alkaline degradation products were stated as potential impurities in British Pharmacopoeia. The degradation products were separated and identified by mass spectra. Postulation of a PHE oxidative degradation pathway was suggested. The obtained results were statistically analyzed and compared with those obtained by applying the official methods for both drugs.
[Mh] Termos MeSH primário: Ciclopentolato/análise
Fenilefrina/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Ciclopentolato/química
Densitometria
Peróxido de Hidrogênio/química
Modelos Químicos
Soluções Oftálmicas
Oxirredução
Fenilefrina/química
Hidróxido de Sódio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ophthalmic Solutions); 1WS297W6MV (Phenylephrine); 55X04QC32I (Sodium Hydroxide); BBX060AN9V (Hydrogen Peroxide); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.16-0215


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[PMID]:27906812
[Au] Autor:Rosman MS; Skaat A; Chien JL; Ghassibi MP; Sarimiye TF; Ritch R; Liebmann JM; Park SC
[Ad] Endereço:*Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai §Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, Columbia University Medical Center ∥Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York ¶Department of Ophthalmology, Hofstra Northwell School of Medicine, Hempstead, NY †Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel ‡George Washington University School of Medicine and Health Sciences, Washington, DC.
[Ti] Título:Effect of Cyclopentolate on In Vivo Schlemm Canal Microarchitecture in Healthy Subjects.
[So] Source:J Glaucoma;26(2):133-137, 2017 Feb.
[Is] ISSN:1536-481X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To characterize the in vivo effect of cyclopentolate on the microstructure of Schlemm canal (SC) in healthy eyes. METHODS: For healthy subjects, 81 serial horizontal enhanced depth imaging optical coherence tomography B-scans (interval between scans, ∼35 µm) of the nasal corneoscleral limbal area were obtained before and 1 hour after cyclopentolate 1% administration in 1 eye. The structures of aqueous and blood vessels in each scan were used as landmarks to select 50 overlapping scans between the 2 sets of 81 serial scans (before and after cyclopentolate administration). The SC cross-sectional area was measured in each of the 50 selected scans. After 3-dimensional reconstruction, SC volume was determined. RESULTS: Twelve eyes (12 healthy subjects) were imaged successfully before and after cyclopentolate administration. Mean age was 27.8±4.9 years (range, 25 to 38 y). Following cyclopentolate administration, mean intraocular pressure did not change significantly (13.9±1.5 to 14.2±1.5 mm Hg; P=0.19). Mean SC cross-sectional area decreased by 17%, from 3563±706 to 2959±460 µm (P<0.001). Mean SC volume in the overlapping area (approximately 1.7 mm of circumferential length of SC) decreased from 6,164,061±1,220,787 to 5,119,462±794,763 µm (P<0.001). The decrease in the mean SC cross-sectional area after cyclopentolate administration was greater in eyes with larger baseline SC cross-sectional area (P<0.001, R=0.873). CONCLUSIONS: Cyclopentolate causes a reduction in SC dimensions in healthy eyes. Future studies are warranted to determine the exact mechanism(s) of this change.
[Mh] Termos MeSH primário: Ciclopentolato/farmacologia
Limbo da Córnea/anatomia & histologia
Limbo da Córnea/efeitos dos fármacos
Midriáticos/farmacologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Voluntários Saudáveis
Seres Humanos
Pressão Intraocular
Masculino
Estudos Prospectivos
Tomografia de Coerência Óptica/métodos
Tonometria Ocular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.1097/IJG.0000000000000599


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[PMID]:27426488
[Au] Autor:Guha S; Shah S; Shah K; Hurakadli P; Majee D; Gandhi S
[Ad] Endereço:Sankara Nethralaya, Kolkata, West Bengal, India.
[Ti] Título:A comparison of cycloplegic autorefraction and retinoscopy in Indian children.
[So] Source:Clin Exp Optom;100(1):73-78, 2017 Jan.
[Is] ISSN:1444-0938
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Correction of significant refractive errors in childhood helps in preventing amblyopia and strabismus. India has a huge demand for eye-care services related to uncorrected refractive errors with limited manpower resources. This can be overcome by autorefractors, which are free of operator bias, do not need skilled eye-care professionals and can be operated with ease. Hence, the purpose of this study, the first in the Indian population, was to determine the accuracy of autorefraction compared to traditional retinoscopy under cycloplegia. METHOD: A cross-sectional study of all children meeting our inclusion criteria was conducted from July till October 2011 in a tertiary eye care centre. Children underwent cycloplegic (cyclopentolate plus tropicamide) refraction with an auto-refractometer (Topcon KR-8900) and traditional retinoscopy and the results were compared. Patients were divided into three groups: Group 1: Myopia and myopic astigmatism, Group 2: Hyperopia and hyperopic astigmatism and Group 3: Mixed astigmatism. Clinically significant difference was defined as either of more than 0.50 D difference in sphere, more than 0.5 D difference in cylinder or more than 20 degrees difference in axis. RESULTS: The left eyes of 294 children (148 male) were included in the study. Mean age was 8.22 ± 3.47 years. Clinically significant differences were noted in 13.22 per cent of eyes in Group 1, 15.09 per cent of eyes in Group 2 and 20.90 per cent of eyes in Group 3. Clinically significant differences were more common in children aged less than six years (25 per cent) compared to older children (9.19 per cent). Comparing the sphere, cylinder, spherical equivalent and length of power vector values gained by autorefraction and retinoscopy, no statistically significant differences were found in any group. CONCLUSION: Autorefraction with Topcon KR-8900 can be used reliably in Indian children older than six years, if conducted under cycloplegia. In mixed astigmatism and children less than six years, it should be corroborated with retinoscopy.
[Mh] Termos MeSH primário: Ciclopentolato/administração & dosagem
Midriáticos/administração & dosagem
Refração Ocular
Retinoscopia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mydriatics); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1111/cxo.12375


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[PMID]:28009338
[Au] Autor:Ahmad A; Mondal T; Klein B
[Ad] Endereço:Department of Pediatrics, McMaster University, ON, Canada.
[Ti] Título:Atrial arrhythmia after newborn eye exam, to caffeine or not to caffeine?
[So] Source:J Neonatal Perinatal Med;9(4):427-431, 2016.
[Is] ISSN:1878-4429
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mydriatic drops are routinely administered to premature neonates to screen for retinopathy of prematurity. Adverse anticholinergic side effects, particularly convulsions and tachycardia have been reported in the pediatric age group following instillation of mydriatics for diagnostic fundus examination [1, 2]. Caffeine is frequently used for apnea of prematurity. In the neonatal intensive care unit, the combined use of caffeine and mydriatic drops is a common practice. Here we report two cases of atrial arrhythmias after neonatal eye exam that improved with conservative management. Both patients were receiving caffeine at the time of events.
[Mh] Termos MeSH primário: Apneia/tratamento farmacológico
Complexos Atriais Prematuros/induzido quimicamente
Bradicardia/induzido quimicamente
Cafeína/efeitos adversos
Estimulantes do Sistema Nervoso Central/efeitos adversos
Midriáticos/efeitos adversos
Oftalmoscopia/métodos
Retinopatia da Prematuridade/diagnóstico
[Mh] Termos MeSH secundário: Ciclopentolato/efeitos adversos
Interações Medicamentosas
Feminino
Fundo de Olho
Seres Humanos
Lactente
Recém-Nascido
Recém-Nascido Prematuro
Fenilefrina/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Central Nervous System Stimulants); 0 (Mydriatics); 1WS297W6MV (Phenylephrine); 3G6A5W338E (Caffeine); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.3233/NPM-160167


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[PMID]:27907165
[Au] Autor:Zhu D; Wang Y; Yang X; Yang D; Guo K; Guo Y; Jing X; Pan CW
[Ad] Endereço:Department of Ophthalmology, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, China.
[Ti] Título:Pre- and Postcycloplegic Refractions in Children and Adolescents.
[So] Source:PLoS One;11(12):e0167628, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine the difference between cycloplegic and non-cycloplegic refractive error and its associated factors in Chinese children and adolescents with a high prevalence of myopia. METHODS: A school-based study including 1565 students aged 6 to 21 years was conducted in 2013 in Ejina, Inner Mongolia, China. Comprehensive eye examinations were performed. Pre-and postcycloplegic refractive error were measured using an auto-refractor. For cycloplegic refraction, one drop of topical 1.0% cyclopentolate was administered to each eye twice with a 5-minute interval and a third drop was administered 15 minutes after the second drop if the pupil size was less than 6 mm or if the pupillary light reflex was still present. RESULTS: Two drops of cyclopentolate were found to be sufficient in 59% of the study participants while the other 41% need an additional drop. The prevalence of myopia was 89.5% in participants aged over 12 years and 68.6% in those aged 12 years or younger (P<0.001). When myopia was defined as spherical equivalent (SE) of less than -0.5 diopter (D), the prevalence estimates were 76.7% (95% confidence interval [CI] 74.6-78.8) and 54.1% (95%CI 51.6-56.6) before and after cycloplegic refraction, respectively. When hyperopia was defined as SE of more than 0.5D, the prevalence was only 2.8% (95%CI 1.9-3.6) before cycloplegic refraction while it was 15.5% (95%CI 13.7-17.3) after cycloplegic refraction. Increased difference between cycloplegic and non-cycloplegic refractive error was associated with decreased intraocular pressures (P = 0.01). CONCLUSIONS: Lack of cycloplegia in refractive error measurement was associated with significant misclassifications in both myopia and hyperopia among Chinese children and adolescents. Decreased intraocular pressure was related to a greater difference between cycloplegic and non-cycloplegic refractive error.
[Mh] Termos MeSH primário: Hiperopia/diagnóstico
Miopia/diagnóstico
Refração Ocular/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
China
Ciclopentolato/administração & dosagem
Feminino
Seres Humanos
Hiperopia/patologia
Miopia/epidemiologia
Erros de Refração/diagnóstico
Erros de Refração/fisiopatologia
Retinoscopia
Testes Visuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167628


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[PMID]:27843084
[Au] Autor:Kalezic T; Vukovic I; Andjelkovic M; Gajic M; Potic J; Stojkovic M
[Ad] Endereço:Département de cornée et des maladies externes, clinique des maladies des yeux, centre clinique de Serbie, faculté de médecine, université de Belgrade, 2, rue Pasterova, 11000 Belgrade, Serbie. Electronic address: tanjakalezic@gmail.com.
[Ti] Título:[The effects of cycloplegic eyedrops on corneal tomography].
[Ti] Título:Effets des gouttes cycloplégiques sur la tomographie cornéenne..
[So] Source:J Fr Ophtalmol;39(10):829-835, 2016 Dec.
[Is] ISSN:1773-0597
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:PURPOSE: Whether cycloplegics affect standard keratorefractometric and tomographic measurements is unknown. The purpose of our study was to compare the effects of cycloplegics (cyclopentolate and atropine) on corneal shape and refractive power of the eye. METHODS: This study was performed on 84 eyes of 49 study participants. Patients were randomized into two groups: atropine 1% (32 eyes) and cyclopentolate 1% (52 eyes). Corneal tomography was performed with the Orbscan IIz. To evaluate the corneal shape, simulated keratometry values, anterior and posterior best-fit sphere, white-to-white and tangential and axial corneal power were performed for the anterior and posterior corneal surfaces before and during cycloplegia. Pupil diameter, anterior chamber depth, corneal thickness at the 3, 5 and 7mm optical zones, thinnest area of the cornea and corneal thickness at the visual axis were examined. Data were analyzed using an SPSS statistical package. RESULTS: The anterior and posterior BFS (in the atropine 1% group, anterior BFS was P=0.188; anterior BFS in the cyclopentolate group was P=0.227) and tangential and axial corneal power showed no change during cycloplegia in either group. SimK showed no statistical significance. The ACD was deeper when using atropine than cyclopentolate. Corneal thickness remained unchanged during cycloplegia in both groups. Pupil diameter was larger in light-colored irides in the cyclopentolate group than the atropine group. There was no change in W to W before (P=0.473) and during cycloplegia (P=0.287) in either group. CONCLUSIONS: Our results suggest that usage of atropine or cyclopentolate does not alter corneal shape.
[Mh] Termos MeSH primário: Atropina/farmacologia
Córnea/efeitos dos fármacos
Topografia da Córnea
Ciclopentolato/farmacologia
Midriáticos/farmacologia
Soluções Oftálmicas/farmacologia
[Mh] Termos MeSH secundário: Adulto
Atropina/administração & dosagem
Córnea/patologia
Córnea/cirurgia
Ciclopentolato/administração & dosagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Midriáticos/administração & dosagem
Refração Ocular/efeitos dos fármacos
Procedimentos Cirúrgicos Refrativos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); 7C0697DR9I (Atropine); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE


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[PMID]:27799585
[Au] Autor:Zurevinsky J; Sawchuk K; Lim HJ; Lee CH; Rubab S
[Ad] Endereço:From the Orthoptic Clinic, Eye Care Centre, Saskatoon Health Region, Saskatoon, Saskatchewan.
[Ti] Título:A Clinical Randomized Trial Comparing the Cycloplegic Effect of Cyclopentolate Drops Applied to Closed Eyelids Versus Open Eyelids.
[So] Source:Am Orthopt J;66(1):114-121, 2016 Jan.
[Is] ISSN:0065-955X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Adequate cycloplegia and dilation are required for refraction and fundus exam in children. Standard practice is to instill cycloplegic drops in the inferior cul-de-sac, and this is often traumatic for children. Our study assesses the use of cyclopentolate on closed lids as a method of instillation for ensuring complete cycloplegia. PATIENTS AND METHOD: Ninety children presenting for annual refraction were enrolled. Three were excluded as they did not finish the testing. One drop of Alcaine and one drop of cyclopentolate HCL 1% were used in each eye. Cyclopentolate drops were placed on the inner canthus near the lid margin on the closed eye and directly onto the conjunctiva of the fellow eye. RESULTS: Overall, 145/174 eyes (83%) were fully cyclopleged with one drop. The methods of instillation were equally successful (seventy-two indirect vs. seventy-three direct). Age, eye color, spherical refractive error, astigmatic refractive error, and presence of amblyopia on the study visit played no role in the success of either method. Dark irises where the pupil margin was clinically indistinguishable had the largest number of failures (n = 17/44) in comparison to light irises (12/130), but had an equal amount of failures for both direct and indirect methods. CONCLUSION: Placing one drop of cyclopentolate HCL 1% on a closed eyelid had a success rate for complete cycloplegia that was equivalent to placing one drop directly on the cornea.
[Mh] Termos MeSH primário: Ciclopentolato/administração & dosagem
Pálpebras/efeitos dos fármacos
Midriáticos/administração & dosagem
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Cor de Olho/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Soluções Oftálmicas
Pupila/efeitos dos fármacos
Retinoscopia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Mydriatics); 0 (Ophthalmic Solutions); I76F4SHP7J (Cyclopentolate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE



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