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[PMID]:29175697
[Au] Autor:Li B; Zhou H; Yang G; Han F; Li Y; Gao Y; Gao J; Zhang F; Sun L
[Ad] Endereço:School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, Liaoning Province, China; School of Pharmacy, Taishan Medical University, Changcheng Road 619, Tai'an, Shandong Province, China.
[Ti] Título:In vivo study of erysolin metabolic profile by ultra high performance liquid chromatography coupleded to Fourier transform ion cyclotron resonance mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1072:173-181, 2018 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An ultra high performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) method was developed for the first time to study the in vivo metabolism of erysolin, a compound derived from cruciferous plants which has a definite effect of anti-tumor and anti-nerve injury. In this research, the chromatographic separation was performed on an ACQUITY UPLC BEH C18 column (2.1 mm×100mm, 1.7µm, Waters, USA) and eluted by a gradient program, the identification work was achieved on a Bruker ultra-high resolution spectrometer in positive ion mode. Plasma, urine, feces and bile samples were collected from rats to screen metabolites after an intragastric administration of erysolin at the dose of 100mg/kg. As a result, the parent drug and a total of six phase II metabolites were detected and preliminarily identified by analyzing their MS and MS/MS spectrometry profiles. Our results indicated that erysolin mainly metabolized via the mercapturic acid metabolic pathway, erysolin first react with glutathione to form glutathione conjugate, followed by taking off the glutamic acid and glycine to form cysteine conjugate, then the N-acetylation reaction occurs, the product would be excreted out of the body at last. In conclusion, results obtained in our study may contribute to a better understanding of the metabolism process and characteristics of erysolin in vivo, and provide an important reference for future research.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Espectrometria de Massas/métodos
Sulfonas/sangue
Tiocianatos/sangue
[Mh] Termos MeSH secundário: Animais
Masculino
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Sulfonas/química
Sulfonas/farmacocinética
Tiocianatos/química
Tiocianatos/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sulfones); 0 (Thiocyanates); 504-84-7 (erysolin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29307179
[Au] Autor:Morroni F; Sita G; Djemil A; D'Amico M; Pruccoli L; Cantelli-Forti G; Hrelia P; Tarozzi A
[Ad] Endereço:Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna , Bologna, Italy.
[Ti] Título:Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.
[So] Source:J Agric Food Chem;66(4):856-865, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several studies suggest that an increase of glutathione (GSH) through activation of the transcriptional nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the dopaminergic neurons may be a promising neuroprotective strategy in Parkinson's disease (PD). Among Nrf2 activators, isothiocyanate sulforaphane (SFN), derived from precursor glucosinolate present in Brassica vegetables, has gained attention as a potential neuroprotective compound. Bioavailability studies also suggest the contribution of SFN metabolites, including erucin (ERN), to the neuroprotective effects of SFN. Therefore, we compared the in vitro neuroprotective effects of SFN and ERN at the same dose level (5 µM) and oxidative treatment with 6-hydroxydopamine (6-OHDA) in SH-SY5Y cells. The pretreatment of SH-SY5Y cells with SFN recorded a higher (p < 0.05) active nuclear Nrf2 protein (12.0 ± 0.4 vs 8.0 ± 0.2 fold increase), mRNA Nrf2 (2.0 ± 0.3 vs 1.4 ± 0.1 fold increase), total GSH (384.0 ± 9.0 vs 256.0 ± 8.0 µM) levels, and resistance to neuronal apoptosis elicited by 6-OHDA compared to ERN. By contrast, the simultaneous treatment of SH-SY5Y cells with either SFN or ERN and 6-OHDA recorded similar neuroprotective effects with both the isothiocyanates (Nrf2 protein 2.2 ± 0.2 vs 2.1 ± 0.1 and mRNA Nrf2 2.1 ± 0.3 vs 1.9 ± 0.2 fold increase; total GSH 384.0 ± 4.8 vs 352.0 ± 6.4 µM). Finally, in vitro finding was confirmed in a 6-OHDA-PD mouse model. The metabolic oxidation of ERN to SFN could account for their similar neuroprotective effects in vivo, raising the possibility of using vegetables containing a precursor of ERN for systemic antioxidant benefits in a similar manner to SFN.
[Mh] Termos MeSH primário: Neurônios Dopaminérgicos/efeitos dos fármacos
Isotiocianatos/farmacologia
Fármacos Neuroprotetores/farmacologia
Doença de Parkinson/prevenção & controle
Sulfetos/farmacologia
Tiocianatos/farmacologia
[Mh] Termos MeSH secundário: Animais
Brassica/química
Linhagem Celular Tumoral
Neurônios Dopaminérgicos/química
Glutationa/análise
Seres Humanos
Isotiocianatos/metabolismo
Isotiocianatos/uso terapêutico
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fator 2 Relacionado a NF-E2/análise
Fator 2 Relacionado a NF-E2/genética
Neuroblastoma
Fármacos Neuroprotetores/uso terapêutico
Oxirredução
Oxidopamina/administração & dosagem
RNA Mensageiro/análise
Sulfetos/metabolismo
Sulfetos/uso terapêutico
Tiocianatos/metabolismo
Tiocianatos/uso terapêutico
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isothiocyanates); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Neuroprotective Agents); 0 (RNA, Messenger); 0 (Sulfides); 0 (Thiocyanates); 8HW4YBZ748 (Oxidopamine); CTE370DL3U (erucin); GA49J4310U (sulforafan); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04641


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[PMID]:28764036
[Au] Autor:Kokotou MG; Revelou PK; Pappas C; Constantinou-Kokotou V
[Ad] Endereço:Chemical Laboratories, Agricultural University of Athens, Iera odos 75, Athens 11855, Greece.
[Ti] Título:High resolution mass spectrometry studies of sulforaphane and indole-3-carbinol in broccoli.
[So] Source:Food Chem;237:566-573, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Broccoli is a rich source of bioactive compounds. Among them, sulforaphane and indole-3-carbinol have attracted a lot of attention, since their consumption is associated with reduced risk of cancer. In this work, the development of an efficient and direct method for the simultaneous determination of sulforaphane and indole-3-carbinol in broccoli using UPLC-HRMS/MS is described. The correlation coefficient, and limits of detection (LOD) and quantification (LOQ) were 0.993, 0.77mg/L and 2.35mg/L for sulforaphane and 0.997, 0.42mg/L, 1.29mg/L for indole-3-carbinol, respectively. The content of sulforaphane and indole-3-carbinol varied between 72±9-304±2mg and 77±1-117±3mg per 100g of fresh florets, respectively. Taking into consideration the differences in cultivar, geography, season and environmental factors, the results agreed with values published in the literature using other techniques.
[Mh] Termos MeSH primário: Brassica
Indóis/análise
Isotiocianatos/análise
[Mh] Termos MeSH secundário: Seres Humanos
Espectrometria de Massas
Tiocianatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Isothiocyanates); 0 (Thiocyanates); C11E72455F (indole-3-carbinol); GA49J4310U (sulforafan)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  4 / 7304 MEDLINE  
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[PMID]:28703651
[Au] Autor:Kim SSR; He X; Braverman LE; Narla R; Gupta PK; Leung AM
[Ti] Título:Letter to the Editor.
[So] Source:Endocr Pract;23(7):885-886, 2017 07.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Brassica/química
Sucos de Frutas e Vegetais
Iodo/urina
Tiocianatos/metabolismo
Glândula Tireoide/metabolismo
Tireotropina/sangue
Tiroxina/sangue
[Mh] Termos MeSH secundário: Seres Humanos
Radioisótopos do Iodo
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Thiocyanates); 302-04-5 (thiocyanate); 9002-71-5 (Thyrotropin); 9679TC07X4 (Iodine); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.4158/1934-2403-23.7.885


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[PMID]:28691485
[Au] Autor:Tan Z; Lou TT; Huang ZX; Zong J; Xu KX; Li QF; Chen D
[Ad] Endereço:State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University , Tianjin 300072, China.
[Ti] Título:Single-Drop Raman Imaging Exposes the Trace Contaminants in Milk.
[So] Source:J Agric Food Chem;65(30):6274-6281, 2017 Aug 02.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Better milk safety control can offer important means to promote public health. However, few technologies can detect different types of contaminants in milk simultaneously. In this regard, the present work proposes a single-drop Raman imaging (SDRI) strategy for semiquantitation of multiple hazardous factors in milk solutions. By developing SDRI strategy that incorporates the coffee-ring effect (a natural phenomenon often presents in a condensed circle pattern after a drop evaporated) for sample pretreatment and discrete wavelet transform for spectra processing, the method serves well to expose typical hazardous molecular species in milk products, such as melamine, sodium thiocyanate and lincomycin hydrochloride, with little sample preparation. The detection sensitivity for melamine, sodium thiocyanate, and lincomycin hydrochloride are 0.1 mg kg , 1 mg kg , and 0.1 mg kg , respectively. Theoretically, we establish that the SDRI represents a novel and environment-friendly method that screens the milk safety efficiently, which could be well extended to inspection of other food safety.
[Mh] Termos MeSH primário: Contaminação de Alimentos/análise
Análise de Perigos e Pontos Críticos de Controle/métodos
Leite/química
Análise Espectral Raman/métodos
[Mh] Termos MeSH secundário: Animais
Tiocianatos/análise
Triazinas/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thiocyanates); 0 (Triazines); 5W0K9HKA05 (sodium thiocyanate); N3GP2YSD88 (melamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01814


  6 / 7304 MEDLINE  
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[PMID]:28632039
[Au] Autor:Willemin ME; Lumen A
[Ad] Endereço:a Division of Biochemical Toxicology , National Center for Toxicological Research, US Food and Drug Administration , Jefferson , AR , USA.
[Ti] Título:Thiocyanate: a review and evaluation of the kinetics and the modes of action for thyroid hormone perturbations.
[So] Source:Crit Rev Toxicol;47(7):537-563, 2017 Aug.
[Is] ISSN:1547-6898
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Exposure of the population to thiocyanate is predominantly through the diet and cigarette smoke. Thiocyanate is a potential thyroid disruptor due to its capacity to inhibit the uptake of iodide by the thyroid. Thiocyanate also interacts with the enzymatic reactions associated with iodide organification and thyroid hormone synthesis. Quantification of the dose-response relationships of thiocyanate and alteration in thyroid hormone levels is important for evaluating the risk of exposure to thiocyanate in humans. In this review, we highlight the key whole-body and intra-thyroidal aspects of thiocyanate kinetics in rats and its various modes of action for perturbing thyroid function. The inter-play between the various transporter- and enzyme-mediated modes of action contributes to the complexity in the dose-response relationship determinations for thiocyanate. We map the available modes of action in a mechanistic and quantitative manner. Findings summarized in this study can help support the development of a quantitative model to study the interaction effects of thiocyanate on the thyroid function. Additionally, the data gaps identified can help guide future experimental designs to characterize further thiocyanate dose-response. Finally, the strengths and weaknesses in current risk assessment considerations used for thiocyanate as a component of thyroid-active chemical mixtures are discussed.
[Mh] Termos MeSH primário: Poluentes Ambientais/toxicidade
Tiocianatos/toxicidade
[Mh] Termos MeSH secundário: Animais
Cinética
Ratos
Glândula Tireoide/efeitos dos fármacos
Hormônios Tireóideos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Thiocyanates); 0 (Thyroid Hormones)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1080/10408444.2017.1281590


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[PMID]:28430972
[Au] Autor:McMullen J; Ghassabian A; Kohn B; Trasande L
[Ad] Endereço:School of Medicine, New York University, New York, New York 10003.
[Ti] Título:Identifying Subpopulations Vulnerable to the Thyroid-Blocking Effects of Perchlorate and Thiocyanate.
[So] Source:J Clin Endocrinol Metab;102(7):2637-2645, 2017 Jul 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Common environmental contaminants can disrupt normal thyroid function, which plays essential but varying roles at different ages. Objective: To evaluate the relationship of perchlorate, thiocyanate, and nitrate, three sodium-iodide symporter (NIS) inhibitors, and thyroid function in different age-sex-stratified populations. Design, Setting, Participants, and Intervention: This was a cross-sectional analysis of data from the 2009 to 2012 National Health and Nutrition Examination Survey evaluating the exposure to perchlorate, thiocyanate, and nitrate in 3151 participants aged 12 to 80. Main Outcome Measure: Blood serum free thyroxine (FT4) as both a continuous and categorical variable. We also assessed blood serum thyroid stimulating hormone. Results: Controlling for serum cotinine, body mass index, total daily energy consumption, race/ethnicity, and poverty-to-income ratio, for each log unit increase in perchlorate, FT4 decreased by 0.03 ng/dL in both the general population (P = 0.004) and in all women (P = 0.005), and by 0.06 ng/dL in adolescent girls (P = 0.029), corresponding to 4% and 8% decreases relative to median FT4, respectively. For each log unit increase thiocyanate, FT4 decreased by 0.07 ng/dL in adolescent boys (P = 0.003), corresponding to a 9% decrease relative to median FT4, respectively. Conclusions: Our results indicate that adolescent boys and girls represent vulnerable subpopulations to the thyroid-blocking effects of NIS symporter inhibitors. These results suggest a valuable screening and intervention opportunity.
[Mh] Termos MeSH primário: Exposição Ambiental/efeitos adversos
Percloratos/efeitos adversos
Tiocianatos/efeitos adversos
Glândula Tireoide/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Criança
Estudos Transversais
Feminino
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
Análise Multivariada
Percloratos/química
Estudos Retrospectivos
Medição de Risco
Fatores Sexuais
Tiocianatos/química
Testes de Função Tireóidea
Tireotropina/sangue
Tiroxina/sangue
Populações Vulneráveis
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Perchlorates); 0 (Thiocyanates); 9002-71-5 (Thyrotropin); Q51BO43MG4 (Thyroxine); VLA4NZX2P4 (perchlorate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2017-00046


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[PMID]:28415515
[Au] Autor:Abdel-Haleem FM; Rizk MS
[Ad] Endereço:Chemistry department, Faculty of Science, Cairo university, Giza, Egypt. Electronic address: fatehy@sci.cu.edu.eg.
[Ti] Título:Highly selective thiocyanate optochemical sensor based on manganese(III)-salophen ionophore.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:682-687, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report on the development of optochemical sensor based on Mn(III)-salophen ionophore. The sensor was prepared by embedding the ionophore in a plasticized poly (vinyl chloride) impregnated with the chromoionophore ETH7075. Optical response to thiocyanate occurred due to thiocyanate extraction into the polymer via formation of strong complex with the ionophore and simultaneous protonation of the indicator dye yielding the optical response at 545nm. The developed optochemical sensor exhibited high selectivity for thiocyanate over other anions including the most lipophilic species such as salicylate and perchlorate. For instance, the optical selectivity coefficients, logK , were as follow: ClO =-5.8; Sal =-4.0; NO Ë‚-6. Further, the thiocyanate optical selectivity obtained using the present optochemical sensor was greatly enhanced in comparison with that obtained using an anion-exchanger based sensor. Also, the optimized optochemical sensor exhibited micro-molar detection limit with 2min response time at pH4.5 using acetate buffer. The reversibility of the optimized sensor was poor due to strong ligation of the thiocyanate to the central Metal ion, log K=14.1, which can be overcome by soaking the optode in sodium hydroxide followed by soaking in buffer solution. The developed sensor was utilized successfully for the determination of thiocyanate in human saliva and in spiked saliva samples.
[Mh] Termos MeSH primário: Ionóforos/química
Manganês/química
Salicilatos/química
Tiocianatos/análise
[Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio
Cloreto de Polivinila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ionophores); 0 (Salicylates); 0 (Thiocyanates); 118-57-0 (salophen); 302-04-5 (thiocyanate); 42Z2K6ZL8P (Manganese); 9002-86-2 (Polyvinyl Chloride)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  9 / 7304 MEDLINE  
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[PMID]:28414980
[Au] Autor:Datta D; J Swamy M
[Ad] Endereço:School of Chemistry, University of Hyderabad, Hyderabad 5000 46, India.
[Ti] Título:Fluorescence and circular dichroism studies on the accessibility of tryptophan residues and unfolding of a jacalin-related α-d-galactose-specific lectin from mulberry (Morus indica).
[So] Source:J Photochem Photobiol B;170:108-117, 2017 May.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:MLGL (Mulberry Latex Galactose-specific Lectin) is an α-d-galactose binding lectin isolated from the latex of mulberry (Morus indica) tree and contains two tryptophan residues in each of its subunits. The fluorescence emission maximum of native MLGL seen at 326nm shifts to 350nm upon incubation with 6M guanidinium thiocyanate (Gdn.SCN), suggesting that the tryptophans are located inside the hydrophobic core of the protein and become fully exposed upon denaturation. Fluorescence quenching studies revealed that the neutral acrylamide exhibits the highest quenching, with ~33% of total fluorescence in the native protein being quenched at a quencher concentration of 0.5M, whereas iodide (~24%) and cesium (~4%) ions showed significantly lower quenching. With the denatured protein, acrylamide quenching involves both dynamic and static processes as evident from an upward curving Stern-Volmer plot. Time-resolved fluorescence studies showed two lifetime components of 3.7ns and 1.3ns for the native protein, while three lifetime components were observed for the denatured protein. MLGL showed high resistance to urea (up to 8M) and guanidine hydrochloride (up to 6M), whereas treatment with 6M Gdn.SCN completely denatured the protein, via a broad sigmoidal transition with a transition midpoint at ~3.75M. Circular dichroism studies and hemagglutination assays showed that the secondary and tertiary structures as well as lectin activity of MLGL were unaffected up to 70°C. Additionally, pH dependent studies showed that the secondary structure of MLGL is unaltered in the pH range 6.2 to 8.5, but a decrease in lectin activity is observed (~50%) at pH6.2.
[Mh] Termos MeSH primário: Galactose/metabolismo
Lectinas/metabolismo
Morus/metabolismo
Lectinas de Plantas/química
Triptofano/química
[Mh] Termos MeSH secundário: Césio/química
Dicroísmo Circular
Galactose/química
Guanidina/química
Guanidinas/química
Concentração de Íons de Hidrogênio
Iodetos/química
Lectinas/química
Estrutura Quaternária de Proteína
Estrutura Secundária de Proteína
Desdobramento de Proteína
Espectrometria de Fluorescência
Temperatura Ambiente
Tiocianatos/química
Ureia/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Guanidines); 0 (Iodides); 0 (Lectins); 0 (Plant Lectins); 0 (Thiocyanates); 0 (jacalin); 1KSV9V4Y4I (Cesium); 593-84-0 (guanidine thiocyanate); 8DUH1N11BX (Tryptophan); 8W8T17847W (Urea); JU58VJ6Y3B (Guanidine); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE


  10 / 7304 MEDLINE  
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[PMID]:28395467
[Au] Autor:Yong L; Zhang L; Wang YB; Yang DJ; Liu ZP; Wang T; Huang JP; Zhou PP
[Ad] Endereço:China National Center for Food Safety Risk Assessment, Beijing 100022, China.
[Ti] Título:[Liquid milk exposure and risk assessment of thiocyanate in Chinese populations].
[So] Source:Zhonghua Yu Fang Yi Xue Za Zhi;51(4):332-335, 2017 Apr 06.
[Is] ISSN:0253-9624
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze liquid milk exposure of thiocyanate among Chinese population and preliminarily assess its health risk. A total of 2 059 raw milk samples were collected during 2013 and 2014 from 12 Chinese provinces, New Zealand and Netherlands. Farms were chosed according to the main sources of dairy companies, the distribution of farms and the yield of milk. Content of thiocyanate were detected by ion chromatography. Liquid milk consumption data were taken from Chinese beverage and alcoholic beverage consumption survey in 18 cities or counties in 9 provinces, including 16 775 subjects older than 3. A simple distribution model was used to estimate the exposure of thiocyanate from liquid milk. The tolerable daily intake (TDI) of thiocyanate was made 0.08 mg·kg(-1)·d(-1). Then the exposures of different age groups were compared with TDI. Finally, 1 331 samples out of 2 059 were detected to contain thiocyanate. The detection rate was 65%. The average concentration of thiocyanate was 2.11 mg/kg, with a range of 0.10-16.20 mg/kg. The general population's consumption of thiocyanate by drinking liquid milk was 0.001 mg · kg(-1) · d(-1), which was lower than TDI. The (95) of general population and consumers were 0.009 mg · kg(-1) · d(-1) and 0.020 mg·kg( -1)·d(-1) respectively, which were also lower than TDI. Mean exposures of population aged 3-6, 7-12, 13-17, 18-59 as well as elderly aged 60 and above were 0.007, 0.003, 0.002, 0.001 and 0.001 mg · kg(-1)·d(-1) respectively, which were all lower than TDI. The results suggested that the health risk of thiocyanate exposure by drinking liquid milk among Chinese population was at a low level. However, milk products for children deserve more concern.
[Mh] Termos MeSH primário: Inocuidade dos Alimentos/métodos
Leite/química
Tiocianatos/química
[Mh] Termos MeSH secundário: Idoso
Animais
Grupo com Ancestrais do Continente Asiático
Criança
Seres Humanos
Países Baixos
Nova Zelândia
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thiocyanates); 302-04-5 (thiocyanate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-9624.2017.04.010



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