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[PMID]: 29478646 [Au] Autor: Minomo K; Ohtsuka N; Nojiri K; Matsumoto R [Ad] Endereço: Center for Environmental Science in Saitama, Kazo, Saitama 347-0115, Japan. Electronic address: minomo.kotaro@pref.saitama.lg.jp. [Ti] Título: Influence of combustion-originated dioxins in atmospheric deposition on water quality of an urban river in Japan. [So] Source: J Environ Sci (China);64:245-251, 2018 Feb. [Is] ISSN: 1001-0742 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Bulk (wet and dry) deposition samples were collected in Saitama Prefecture, Japan throughout a year (February 8, 2012 to February 7, 2013) to estimate the influence of dioxins emitting from waste incinerators on river water quality. The annual deposition flux of dioxins was 3.3ng-toxic equivalent (TEQ)/m /year. Source identification using indicative congeners estimated that 82% of dioxin TEQ in the bulk deposition (2.7ng-TEQ/m /year) was combustion-originated, indicating that most of the dioxins in the deposition were derived from waste incinerators. In Saitama prefecture the annual flux of combustion-originated dioxins in depositions was apparently consistent with that of dioxin emission into the air from waste incinerators. The TEQ of combustion-originated dioxins in the deposition per rainfall was 2.4pg-TEQ/L on annual average, exceeding the environmental quality standard (EQS) for water in Japan of 1pg-TEQ/L. This suggests there is a possibility that dioxins in atmospheric deposition have a significant influence on the water quality of urban rivers which rainwater directly flows into because of many paved areas in the basins. The influence of combustion-originated dioxin in the deposition on the water quality of Ayase River, an urban river heavily polluted with dioxins, was estimated at 0.29pg-TEQ/L on annual average in 2015. It seems that dioxins in atmospheric deposition from waste incinerators have a significant influence on water quality of some urban rivers via rainwater though the dioxins in the ambient air have achieved the EQS for atmosphere at all monitoring sites in Japan. [Mh] Termos MeSH primário: Poluentes Atmosféricos/análise Atmosfera/química Dioxinas/análise Monitoramento Ambiental Incineração [Mh] Termos MeSH secundário: Japão Chuvas/química Rios/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Air Pollutants); 0 (Dioxins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180227 [St] Status: MEDLINE

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[PMID]: 29406108 [Au] Autor: Xu T; Xie HQ; Li Y; Xia Y; Sha R; Wang L; Chen Y; Xu L; Zhao B [Ad] Endereço: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100085, China. Electronic address: xutuan2012@163.com. [Ti] Título: Dioxin induces expression of hsa-miR-146b-5p in human neuroblastoma cells. [So] Source: J Environ Sci (China);63:260-267, 2018 Jan. [Is] ISSN: 1001-0742 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Dioxin can cause a series of neural toxicological effects. MicroRNAs (miRs) play important roles in regulating nervous system function and mediating cellular responses to environmental pollutants, such as dioxin. Hsa-miR-146b-5p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-miR-146b-5p. We found that the hsa-miR-146b-5p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line. Potential roles of hsa-miR-146b-5p in mediating neural toxicological effects of dioxin may be due to the regulation of certain target genes. We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3'-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Functional bioinformatic analysis showed that the known and predicted target genes of hsa-miR-146b-5p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which AChE may serve as a responsive gene for mediating the effect. [Mh] Termos MeSH primário: Dioxinas/toxicidade Poluentes Ambientais/toxicidade [Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo Linhagem Celular Tumoral Expressão Gênica/efeitos dos fármacos Seres Humanos MicroRNAs/metabolismo Neuroblastoma Testes de Toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dioxins); 0 (Environmental Pollutants); 0 (MIRN146 microRNA, human); 0 (MicroRNAs); EC 3.1.1.7 (Acetylcholinesterase) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180207 [St] Status: MEDLINE

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[PMID]: 28951041 [Au] Autor: Chen Y; Lin K; Chen D; Wang K; Zhou W; Wu Y; Huang X [Ad] Endereço: State Key Laboratory of Marine Environmental Science, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem, College of the Environment and Ecology, Xiamen University, Xiamen 361102, China; College of Environment, Zhejiang University of Technology, Hangzhou 310032, China. [Ti] Título: Formation of environmentally relevant polyhalogenated carbazoles from chloroperoxidase-catalyzed halogenation of carbazole. [So] Source: Environ Pollut;232:264-273, 2018 Jan. [Is] ISSN: 1873-6424 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Polyhalogenated carbazoles (PHCs) are a class of emerging organic contaminants that have received increasing concern due to their widespread distribution and dioxin-like toxicity. Although previous studies have suggested possible natural sources of PHCs in the environment, the formation pathways are poorly understood. Here we explored the production of PHCs from halogenation of carbazole in the presence of Br and/or Cl under the catalysis of chloroperoxidase (CPO) isolated from the marine fungus Caldariomyces fumago. Overall, a total of 25 congeners including mono-to tetra-substituted chlorinated, brominated, and mixed halogenated carbazoles (with substitution patterns of -BrCl, -BrCl , -BrCl , -Br Cl, -Br Cl , and -Br Cl) were produced from the reactions under various conditions. The PHC product profiles were apparently dependent on the halide concentrations. In the CPO-mediated chlorination of carbazole, 3-mono- and 3,6-dichlorocarbazoles predominated in the formation products. In addition to the less abundant mixed halogenated carbazoles (-Br Cl), 1,3,6-tri- and 1,3,6,8-tetrabromocarbazoles were the dominant products in reactions containing both Br and Cl . The CPO-catalyzed halogenation of carbazole could take place in pH 3-7, but the formation products were pH dependent. Results of this study suggest that CPO-catalyzed halogenation of carbazole may play an important role in the natural formation of PHCs. [Mh] Termos MeSH primário: Carbazóis/química Cloreto Peroxidase/química Modelos Químicos [Mh] Termos MeSH secundário: Carbazóis/toxicidade Catálise Dioxinas Meio Ambiente Halogenação Bifenilos Policlorados Dibenzodioxinas Policloradas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Carbazoles); 0 (Dioxins); 0 (Polychlorinated Dibenzodioxins); 0P2197HHHN (carbazole); DFC2HB4I0K (Polychlorinated Biphenyls); EC 1.11.1.10 (Chloride Peroxidase) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180119 [Lr] Data última revisão: 180119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170928 [St] Status: MEDLINE

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[PMID]: 28910589 [Au] Autor: Tairova Z; Strand J; Bossi R; Larsen MM; Förlin L; Bignert A; Hedman J; Gercken J; Lang T; Fricke NF; Asmund G; Long M; Bonefeld-Jørgensen EC [Ad] Endereço: a Department of Bioscience , Aarhus University , Roskilde , Denmark. [Ti] Título: Persistent organic pollutants and related biological responses measured in coastal fish using chemical and biological screening methods. [So] Source: J Toxicol Environ Health A;80(16-18):862-880, 2017. [Is] ISSN: 1528-7394 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The aim of this study was to investigate the spatial distribution, levels of dioxin-like compounds (DLC), and biological responses in two fish species. The viviparous eelpout (Zoarces viviparus) was collected from various locations in the Baltic Sea and in fjords of Kattegat and Skagerrak, while shorthorn sculpin (Myoxocephalus scorpius) was obtained at the polychlorinated biphenyl (PCB) polluted site in North West Greenland. Significant differences were detected both in contaminant levels and relative contributions from either polychlorinated dibenzodioxins (PCDD) or polychlorinated dibenzofurans (PCDF or furans) and mono-ortho- and non-ortho (coplanar) polychlorinated biphenyls (dl-PCB). Fish from the eastern Baltic Sea generally displayed higher contributions from PCDD/F compared to dl-PCB, whereas dl-PCB were generally predominated in fish from Danish, Swedish, and German sites. Levels of dl-PCB in muscle tissues were above OSPAR environmental assessment criteria (EAC) for PCB118, indicating a potential risk of adverse biological effects in the ecosystem, whereas levels of the total WHO-TEQs were below threshold for sea food suggesting limited risks for humans. No significant relationships between levels of DLC (expressed as WHO-TEQ), and biological responses such as the induction of CYP1A enzymatic activity and fry reproductive disorders were observed in eelpout. No marked relationship between WHO-TEQ and combined biological aryl hydrocarbon receptor-mediated transactivity (expressed as AhR-TEQ) was noted. However, there was a positive correlation between polycyclic aromatic hydrocarbon (PAH) metabolites and induction of CYP1A activity, suggesting that PAH exhibited greater potential than DLC to produce biological effects in eelpout from the Baltic Sea. [Mh] Termos MeSH primário: Monitoramento Ambiental Peixes/metabolismo Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: Animais Citocromo P-450 CYP1A1/genética Citocromo P-450 CYP1A1/metabolismo Dioxinas/análise Dioxinas/toxicidade Contaminação de Alimentos/análise Alemanha Groenlândia Bifenilos Policlorados/análise Dibenzodioxinas Policloradas/análise Hidrocarbonetos Aromáticos Policíclicos/análise Receptores de Hidrocarboneto Arílico/metabolismo Reprodução/efeitos dos fármacos Alimentos Marinhos/análise Água do Mar/química Suécia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dioxins); 0 (Polychlorinated Dibenzodioxins); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Receptors, Aryl Hydrocarbon); 0 (Water Pollutants, Chemical); DFC2HB4I0K (Polychlorinated Biphenyls); EC 1.14.14.1 (Cytochrome P-450 CYP1A1) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170915 [St] Status: MEDLINE [do] DOI: 10.1080/15287394.2017.1372870

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[PMID]: 28898241 [Au] Autor: Leijs MM; Koppe JG; Vulsma T; Olie K; van Aalderen WMC; de Voogt P; Legler J; Ten Tusscher GW [Ad] Endereço: Department of Paediatrics and Neonatology, Emma Children's Hospital Academic Medical Center, Amsterdam, The Netherlands. [Ti] Título: Alterations in the programming of energy metabolism in adolescents with background exposure to dioxins, dl-PCBs and PBDEs. [So] Source: PLoS One;12(9):e0184006, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Dioxins and PCBs are highly toxic and persistent environmental pollutants that are measurable in humans worldwide. These persistent organic pollutants are associated with a higher incidence of diabetes mellitus. We hypothesise that perinatal (background) exposure to industrial pollutants like dioxins also influences body mass development and energy metabolism in later life. STUDY DESIGN: In The Netherlands, the perinatal exposure (prenatal exposure and postnatal lactational intake) to dioxins has been studied prospectively since 1987. Fasting glucose, insulin, HbA1c and leptin were analysed in 33 children of the original cohort of 60. BMI, glucose:insulin and BMI:leptin ratios were calculated. Prenatal exposure, lactational intake and current serum levels of dioxins (PCDD/F), dl-PCBs and PBDE concentrations were determined using (HR)GC-MS. RESULTS: Prenatal dioxin (PCDD/F) exposure was positively correlated to the glucose:insulin ratio (p = 0.024) and negatively correlated to the fasting insulin concentration (p = 0.017) in adolescence. Postnatal lactational PCDD/F intake was also negatively correlated to fasting insulin concentration (p = 0.028). Current serum levels of PCDD/Fs and total TEQ (dl-PCBs+PCDD/Fs) were positively correlated to the fasting serum glucose concentration (p = 0.015 and p = 0.037, respectively).No metabolic effects were seen in association with current serum levels of PBDEs. A positive correlation between the insulin and leptin concentrations (p = 0.034) was observed. No effects were found on leptin levels, BMI:leptin ratio, HbA1c levels or BMI. DISCUSSION/CONCLUSION: This study indicates that prenatal and lactational exposure influences glucose metabolism in adolescents, presumably through a negative effect on insulin secretion by pancreatic beta cells. Additionally, the very low recent background exposure to dioxins in puberty possibly has an effect on the glucose level. [Mh] Termos MeSH primário: Dioxinas/toxicidade Metabolismo Energético/efeitos dos fármacos [Mh] Termos MeSH secundário: Adolescente Adulto Biomarcadores Glicemia Índice de Massa Corporal Dioxinas/sangue Exposição Ambiental/efeitos adversos Poluentes Ambientais/toxicidade Feminino Hemoglobina A Glicada Seres Humanos Insulina/sangue Leptina/sangue Masculino Exposição Materna/efeitos adversos Países Baixos Bifenilos Policlorados/sangue Bifenilos Policlorados/toxicidade Dibenzodioxinas Policloradas/sangue Dibenzodioxinas Policloradas/toxicidade Gravidez Puberdade/efeitos dos fármacos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Blood Glucose); 0 (Dioxins); 0 (Environmental Pollutants); 0 (Glycated Hemoglobin A); 0 (Insulin); 0 (Leptin); 0 (Polychlorinated Dibenzodioxins); 0 (hemoglobin A1c protein, human); DFC2HB4I0K (Polychlorinated Biphenyls) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170913 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0184006

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[PMID]: 28838694 [Au] Autor: Banerjee S; Chattopadhyay A; Fernandes JRD; Banerjee A; Phadte AA; Savardekar AV; Singh KS [Ad] Endereço: Birla Institute of Technology and Science-Pilani, K.K. Birla Goa Campus, NH-17B Bypass, Zuarinagar, Goa 403726, India. Electronic address: subhadeepb@goa.bits-pilani.ac.in. [Ti] Título: Synthesis and electronic properties of ester substituted 1,4-dicyanodibenzodioxins and evaluation of anti-proliferative activity of all isomeric 1,2-, 2,3- and 1,4-dicyanodibenzodioxins against HeLa cell line. [So] Source: Bioorg Med Chem Lett;27(18):4280-4284, 2017 09 15. [Is] ISSN: 1464-3405 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: 1,4-Dicyanodibenzodioxins bearing carboxy methyl ester groups were synthesized using our established one-step SNAr coupling reaction between ortho- and meta-ester substituted catechols and perfluorinated terephthalonitrile. These are the first examples of 1,4-dicyanodibenzodioxins substituted at both the benzene moieties. Optical spectra were similar to the earlier examples reported, with a marginal blue shift for the ester dibenzodioxins. Theoretical analysis of the molecular orbitals reveals modest destabilization of the frontier molecular orbitals of one carboxy methyl ester isomer over the other and overall higher HOMO-LUMO gap for both isomers when compared to the earlier published 1,4-dicyanodibenzodioxins. In vitro cytotoxicity against human cervical cancer HeLa cell line was evaluated for these two compounds and all other previously published dibenzodioxins from our laboratory (1,4-dicyano, 1,2-dicyano and 2,3-dicyano variants). A number of derivatives showed anti-tumor activity in µM ranges and also exhibited no cytotoxicity against normal HEK 293 cell line. Mechanistic investigation of cell death pathways indicated high levels of reactive oxygen species (ROS) in the dibenzodioxin treated tumor cell lines along with cellular nuclear fragmentation, both of which are markers of the apoptotic cell death pathway. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Dioxinas/farmacologia Ésteres/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/síntese química Antineoplásicos/química Proliferação Celular/efeitos dos fármacos Dioxinas/síntese química Dioxinas/química Relação Dose-Resposta a Droga Ensaios de Seleção de Medicamentos Antitumorais Elétrons Ésteres/síntese química Ésteres/química Células HeLa Seres Humanos Estrutura Molecular Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Dioxins); 0 (Esters) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171125 [Lr] Data última revisão: 171125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170826 [St] Status: MEDLINE

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[PMID]: 28803151 [Au] Autor: Nakajima S; Saijo Y; Miyashita C; Ikeno T; Sasaki S; Kajiwara J; Kishi R [Ad] Endereço: School of Health Sciences, Sapporo Medical University, Minami 1, Nishi 17, Chuo-ku, Sapporo 060-8556, Japan. Electronic address: sonomi@sapmed.ac.jp. [Ti] Título: Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children: Sapporo cohort study. [So] Source: Environ Res;159:222-231, 2017 11. [Is] ISSN: 1096-0953 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known. OBJECTIVES: We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects. METHODS: The levels of all and each individual DLC isomers were estimated in maternal peripheral blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development-2nd Edition for 6-month-old infants (n = 190) and 18-month-old children (n = 121). RESULTS: In male children, levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables. However, at 18 months of age, these associations were absent. In female children, the level of only one DLC isomer was significantly negatively associated with PDI at 6 months of age. However, in contrast to the male children, the levels of six DLC isomers in 18-month-old female children were significantly positively associated with the Mental Developmental Index. CONCLUSIONS: These findings indicate that adverse neurodevelopmental effects of prenatal background-level exposure to DLCs may be stronger in male children. [Mh] Termos MeSH primário: Desenvolvimento Infantil/efeitos dos fármacos Dioxinas/sangue Dioxinas/toxicidade Exposição Ambiental Poluentes Ambientais/sangue Transtornos do Neurodesenvolvimento/induzido quimicamente Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente [Mh] Termos MeSH secundário: Feminino Seres Humanos Lactente Japão Masculino Gravidez Estudos Prospectivos Fatores Sexuais [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Dioxins); 0 (Environmental Pollutants) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171120 [Lr] Data última revisão: 171120 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170814 [St] Status: MEDLINE

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[PMID]: 28686496 [Au] Autor: Rawn DFK; Dowd M; Scuby MJS; Pantazopoulos PP; Feeley M [Ad] Endereço: 1 Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, 2203C, Tunney's Pasture, Ottawa, Ontario, Canada K1A 0K9. [Ti] Título: Polychlorinated Biphenyls and Polychlorinated Dioxins-Furans in Lake Trout and Whitefish Composite Samples from Commercial Fisheries in Lakes Erie, Huron, and Superior. [So] Source: J Food Prot;80(8):1228-1238, 2017 Aug. [Is] ISSN: 1944-9097 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Polychlorinated biphenyls (PCBs; sum of 36 congeners) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs; sum of 17 2,3,7,8-substituted congeners) were measured in 93 composite samples prepared from individual lake trout (Salvelinus namaycush) and whitefish (Coregonus clupeaformis) samples collected from Lake Erie, Lake Huron, and Lake Superior. All samples had detectable concentrations of PCBs and PCDD/Fs; maximum PCB concentrations in both trout (750 ng g whole weight [ww]) and whitefish (210 ng g ww) were found in composites from fish collected from Lake Huron. The maximum toxic equivalent concentration was found in a lake trout composite sample from Lake Huron (53 pg g ww). PCB and PCDD/F congener profiles were comparable to patterns observed in fishes collected from other regions of Canada, although concentrations were above those found in other regions. A positive correlation was found between PCB concentrations determined using the historical Aroclor equivalency method and those determined using the sum of the congeners measured (r = 0.871; Spearman correlation r = 0.917) or using the six indicator PCB congeners (28, 52, 101, 138, 153, and 180; r = 0.850; Spearman correlation r = 0.935). PCBs were the dominant contributor to the overall toxic equivalent concentrations in the fish composite samples tested. These findings provide insight into PCB and PCDD/F concentrations in two commercially important fish species over a discrete time period. [Mh] Termos MeSH primário: Dioxinas/isolamento & purificação Contaminação de Alimentos/análise Bifenilos Policlorados/isolamento & purificação Salmonidae/metabolismo Truta/metabolismo [Mh] Termos MeSH secundário: Animais Canadá Pesqueiros Furanos Lagos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dioxins); 0 (Furans); DFC2HB4I0K (Polychlorinated Biphenyls) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170708 [St] Status: MEDLINE [do] DOI: 10.4315/0362-028X.JFP-16-530

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[PMID]: 28550783 [Au] Autor: Wang Q; Kelly BC [Ad] Endereço: Department of Civil and Environmental Engineering, National University of Singapore, Singapore. [Ti] Título: Occurrence, distribution and bioaccumulation behaviour of hydrophobic organic contaminants in a large-scale constructed wetland in Singapore. [So] Source: Chemosphere;183:257-265, 2017 Sep. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: This study involved a field-based investigation to assess the occurrence, distribution and bioaccumulation behaviour of hydrophobic organic contaminants in a large-scale constructed wetland. Samples of raw leachate, water and wetland plants, Typha angustifolia, were collected for chemical analysis. Target contaminants included polychlorinated biphenyls (PCBs), organochlorine pesticides (OCP), as well as several halogenated flame retardants (HFRs) and personal care products (triclosan and synthetic musks). In addition to PCBs and OCPs, synthetic musks, triclosan (TCS) and dechlorane plus stereoisomers (syn- and anti-DPs) were frequently detected. Root concentration factors (log RCF L/kg wet weight) of the various contaminants ranged between 3.0 and 7.9. Leaf concentration factors (log LCF L/kg wet weight) ranged between 2.4 and 8.2. syn- and anti-DPs exhibited the greatest RCF and LCF values. A strong linear relationship was observed between log RCF and octanol-water partition coefficient (log K ). Translocation factors (log TFs) were negatively correlated with log K . The results demonstrate that more hydrophobic compounds exhibit higher degrees of partitioning into plant roots and are less effectively transported from roots to plant leaves. Methyl triclosan (MTCS) and 2,8-dichlorodibenzo-p-dioxin (DCDD), TCS degradation products, exhibited relatively high concentrations in roots and leaves., highlighting the importance of degradation/biotransformation. The results further suggest that Typha angustifolia in this constructed wetland can aid the removal of hydrophobic organic contaminants present in this landfill leachate. The findings will aid future investigations regarding the fate and bioaccumulation of hydrophobic organic contaminants in constructed wetlands. [Mh] Termos MeSH primário: Monitoramento Ambiental/métodos Compostos Orgânicos/análise Typhaceae/metabolismo Poluentes Químicos da Água/análise Zonas Úmidas [Mh] Termos MeSH secundário: Dioxinas/análise Dioxinas/metabolismo Retardadores de Chama/análise Retardadores de Chama/metabolismo Hidrocarbonetos Clorados/análise Hidrocarbonetos Clorados/metabolismo Interações Hidrofóbicas e Hidrofílicas Compostos Orgânicos/metabolismo Praguicidas/análise Praguicidas/metabolismo Bifenilos Policlorados/análise Bifenilos Policlorados/metabolismo Compostos Policíclicos/análise Compostos Policíclicos/metabolismo Singapura Triclosan/análogos & derivados Triclosan/análise Triclosan/metabolismo Typhaceae/crescimento & desenvolvimento Poluentes Químicos da Água/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dioxins); 0 (Flame Retardants); 0 (Hydrocarbons, Chlorinated); 0 (Organic Chemicals); 0 (Pesticides); 0 (Polycyclic Compounds); 0 (Water Pollutants, Chemical); 0 (dechlorane plus); 4NM5039Y5X (Triclosan); 5174UR1DP5 (methyl triclosan); DFC2HB4I0K (Polychlorinated Biphenyls); JPA391PZI1 (2,8-dichlorodibenzo-4-dioxin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170528 [St] Status: MEDLINE

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[PMID]: 28550780 [Au] Autor: Götz R; Bergemann M; Stachel B; Umlauf G [Ad] Endereço: Nettelhof 6, D-22609 Hamburg, Germany. Electronic address: rainer.goetzgoetz@web.de. [Ti] Título: Dioxin in the river Elbe. [So] Source: Chemosphere;183:229-241, 2017 Sep. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: This paper provides a macro-analysis of the dioxin contamination in the river Elbe from the 1940s to the present. Based on different data sets, the historic dioxin concentration in the Elbe has been reconstructed. For the section between the tributary Mulde and Hamburg, during the 1940s, we find a concentration of about 1500 pg WHO-TEQ g . We argue that this dioxin contamination was caused mainly by emissions from a magnesium plant in Bitterfeld-Wolfen, whose effluents were discharged into a tributary of the river Mulde which flows into the Elbe. Dioxin pattern recognition with neural networks (Kohonen) confirms this. A model simulation shows that a hypothetical dioxin concentration of 10,000 pg WHO-TEQ g in the tributary Mulde could have caused the reconstructed dioxin concentration of 1500 pg WHO-TEQ g in the Elbe. The recent dioxin concentration (about 25-100 pg WHO-TEQ g ) in the river Elbe, downstream the tributary Mulde, originates, according to our hypothesis, from emissions of the banks and the highly contaminated flood plains (transport of the particle bound dioxin). As other possible dioxin sources, the following could be excluded: the dioxin concentration in the Mulde, groynes, small ports, sport boat harbours, and extreme floods. Our hypothesis is supported by the results of pattern recognition techniques and a model simulation. According to these findings, we argue that remediation efforts to reduce the dioxin concentration in the river Elbe are unlikely to be successful. [Mh] Termos MeSH primário: Dioxinas/análise Monitoramento Ambiental/métodos Sedimentos Geológicos/química Modelos Teóricos Rios/química Poluentes Químicos da Água/análise [Mh] Termos MeSH secundário: Análise por Conglomerados Monitoramento Ambiental/história Alemanha História do Século XX História do Século XXI Redes Neurais (Computação) [Pt] Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dioxins); 0 (Water Pollutants, Chemical) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171003 [Lr] Data última revisão: 171003 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170528 [St] Status: MEDLINE

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