Base de dados : MEDLINE
Pesquisa : D02.309.750.500 [Categoria DeCS]
Referências encontradas : 1150 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 115 ir para página                         

  1 / 1150 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28211332
[Au] Autor:Pizzini S; Sbicego C; Corami F; Grotti M; Magi E; Bonato T; Cozzi G; Barbante C; Piazza R
[Ad] Endereço:Institute for the Dynamics of Environmental Processes, National Research Council (CNR-IDPA), Via Torino, 155, 30172 Venice Mestre, VE, Italy. Electronic address: sarah.pizzini@idpa.cnr.it.
[Ti] Título:3,3'-dichlorobiphenyl (non-Aroclor PCB-11) as a marker of non-legacy PCB contamination in marine species: comparison between Antarctic and Mediterranean bivalves.
[So] Source:Chemosphere;175:28-35, 2017 May.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study the accumulation of the 3,3'-dichlorobiphenyl (PCB-11) in monitoring organisms from the Antarctic and Mediterranean coastal environments has been investigated. This lesser-known PCB congener, unrelated to the industrial use of commercial mixtures, continues to be generated and released into the environment mainly as an unintentional by-product of pigment manufacturing. Specimens of the filter-feeders Adamussium colbecki from Terra Nova Bay and of Mytilus galloprovincialis and Ruditapes philippinarum from the north-western Adriatic coasts were collected and analyzed for PCB-11 by Gas Chromatography coupled both to Low-Resolution and High-Resolution Mass Spectrometry (LRMS, HRMS). In order to assess the influence of PCB-11 with respect to the legacy contamination, 126 PCB congeners related to the Aroclor commercial mixtures were simultaneously analyzed. PCB-11 was detected in all the samples, regardless of the species and of the geographical area, representing on average 17.6% and 15.6% of the total PCBs (n = 127) in Antarctic and Mediterranean samples, respectively. In the Adriatic area the highest concentrations were related to the influence of industrial activities or ship traffic, while the highest value found in Antarctic specimens, namely those collected in the austral summer 1997-1998, was ascribed to a local anthropogenic source. The occurrence of PCB-11 in the other samples from Terra Nova Bay may be related to Long-Range Atmospheric Transport (LRAT), facilitated by the higher volatility of the analyte compared to the heavier PCB congeners. Nevertheless, more in-depth studies are needed in order to evaluate the relative contribution of local and distant sources.
[Mh] Termos MeSH primário: Bivalves/química
Monitoramento Ambiental/métodos
Poluentes Ambientais/análise
Bifenilos Policlorados/análise
[Mh] Termos MeSH secundário: Animais
Regiões Antárticas
Organismos Aquáticos/química
Arocloros/análise
Cromatografia Gasosa-Espectrometria de Massas
Região do Mediterrâneo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Environmental Pollutants); 62U12S7CJZ (3,3'-dichlorobiphenyl); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


  2 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28163111
[Au] Autor:Wahlang B; Perkins JT; Petriello MC; Hoffman JB; Stromberg AJ; Hennig B
[Ad] Endereço:Superfund Research Center, University of Kentucky, Lexington, KY, 40536, USA; Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, 40536, USA.
[Ti] Título:A compromised liver alters polychlorinated biphenyl-mediated toxicity.
[So] Source:Toxicology;380:11-22, 2017 Apr 01.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Exposure to environmental toxicants namely polychlorinated biphenyls (PCBs) is correlated with multiple health disorders including liver and cardiovascular diseases. The liver is important for both xenobiotic and endobiotic metabolism. However, the responses of an injured liver to subsequent environmental insults has not been investigated. The current study aims to evaluate the role of a compromised liver in PCB-induced toxicity and define the implications on overall body homeostasis. Male C57Bl/6 mice were fed either an amino acid control diet (CD) or a methionine-choline deficient diet (MCD) during the 12-week study. Mice were subsequently exposed to either PCB126 (4.9mg/kg) or the PCB mixture, Arcolor1260 (20mg/kg) and analyzed for inflammatory, calorimetry and metabolic parameters. Consistent with the literature, MCD diet-fed mice demonstrated steatosis, indicative of a compromised liver. Mice fed the MCD-diet and subsequently exposed to PCB126 showed observable wasting syndrome leading to mortality. PCB126 and Aroclor1260 exposure worsened hepatic fibrosis exhibited by the MCD groups. Interestingly, PCB126 but not Aroclor1260 induced steatosis and inflammation in CD-fed mice. Mice with liver injury and subsequently exposed to PCBs also manifested metabolic disturbances due to alterations in hepatic gene expression. Furthermore, PCB exposure in MCD-fed mice led to extra-hepatic toxicity such as upregulated circulating inflammatory biomarkers, implicating endothelial cell dysfunction. Taken together, these results indicate that environmental pollution can exacerbate toxicity caused by diet-induced liver injury which may be partially due to dysfunctional energy homeostasis. This is relevant to PCB-exposed human cohorts who suffer from alcohol or diet-induced fatty liver diseases.
[Mh] Termos MeSH primário: Fígado Gorduroso/fisiopatologia
Cirrose Hepática/fisiopatologia
Fígado/efeitos dos fármacos
Bifenilos Policlorados/toxicidade
[Mh] Termos MeSH secundário: Adipocinas/sangue
Animais
Arocloros/toxicidade
Biomarcadores/sangue
Glicemia/metabolismo
Doenças Cardiovasculares/sangue
Doenças Cardiovasculares/induzido quimicamente
Doenças Cardiovasculares/patologia
Colina/administração & dosagem
Dieta
Modelos Animais de Doenças
Metabolismo Energético
Fígado Gorduroso/sangue
Fígado Gorduroso/induzido quimicamente
Expressão Gênica
Homeostase/efeitos dos fármacos
Inflamação/sangue
Inflamação/induzido quimicamente
Fígado/fisiopatologia
Cirrose Hepática/sangue
Cirrose Hepática/induzido quimicamente
Masculino
Metionina/administração & dosagem
Metionina/deficiência
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Aroclors); 0 (Biomarkers); 0 (Blood Glucose); 11096-82-5 (aroclor 1260); AE28F7PNPL (Methionine); DFC2HB4I0K (Polychlorinated Biphenyls); N91BDP6H0X (Choline); TSH69IA9XF (3,4,5,3',4'-pentachlorobiphenyl)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE


  3 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27889511
[Au] Autor:Rodenburg LA; Ralston DK
[Ad] Endereço:Department of Environmental Science, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA. Electronic address: rodenburg@envsci.rutgers.edu.
[Ti] Título:Historical sources of polychlorinated biphenyls to the sediment of the New York/New Jersey Harbor.
[So] Source:Chemosphere;169:450-459, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Using dated sediment cores, polychlorinated biphenyl (PCB) congener concentrations in the New York/New Jersey Harbor and Lower Hudson River were investigated using Positive Matrix Factorization. Of the seven factors resolved, six represent Aroclors in various stages of weathering. Factor 1 resembles Aroclor 1242 and is consistent with the Upper Hudson River PCB signal associated with the General Electric capacitor plants near Hudson Falls, NY. This factor is the dominant source of PCBs in the upper layers of the sediment core collected in the Lower Hudson River. Factor 2 (Aroclor 1248) was the dominant PCB component in the core depths corresponding with around 1970, but it has decreased more rapidly since its peak (estimated half-life of about 5 years) than factor 1 (half-life of about 14 years), suggesting that PCBs from the Upper Hudson have delayed the recovery of the Harbor from PCB contamination. The seventh factor, comprised of PCBs 206, 208, and 209, was greatest in concentration in the deepest core slices and is thought be associated with inadvertent production of PCBs during the manufacture of titanium dioxide and/or with foundry waxes containing PCBs. PCB 11, which is thought to be associated with the use of color organic pigments, was examined separately and was detected in sediment throughout the Harbor. Its maximum concentrations generally occurred at the same depth as the maximum total PCB concentrations, suggesting that PCB 11 concentrations decreased after the mid-1970s.
[Mh] Termos MeSH primário: Sedimentos Geológicos/química
Bifenilos Policlorados/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Arocloros/análise
Monitoramento Ambiental
Meia-Vida
História do Século XX
História do Século XXI
Seres Humanos
New Jersey
New York
Rios
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Water Pollutants, Chemical); 12672-29-6 (aroclor 1248); 53469-21-9 (aroclor 1242); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


  4 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27855955
[Au] Autor:Papale M; Giannarelli S; Francesconi S; Di Marco G; Mikkonen A; Conte A; Rizzo C; De Domenico E; Michaud L; Giudice AL
[Ad] Endereço:Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Messina, Italy.
[Ti] Título:Enrichment, isolation and biodegradation potential of psychrotolerant polychlorinated-biphenyl degrading bacteria from the Kongsfjorden (Svalbard Islands, High Arctic Norway).
[So] Source:Mar Pollut Bull;114(2):849-859, 2017 Jan 30.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), have been detected in abiotic Arctic matrices: surface sediments and seawater from coastal areas in the Kongsfjorden were collected and analyzed. Levels of PCBs varied depending on the sampling site. Total PCB concentrations were between 11.63 (site C2W) and 27.69pgl (site AW). These levels were comparable to those reported previously in lake sediments from the northern Svalbard. The occurrence and biodegradation potential of cold-adapted PCB-oxidizing bacteria in seawater and sediment along the fjord was also evaluated. After enrichment with biphenyl, 246 isolates were obtained with 45 of them that were able to grow in the presence of the PCB mixture Aroclor 1242, as the sole carbon source. The catabolic gene bphA was harbored by 17 isolates with affiliates to the genera Algoriphagus, Devosia and Salinibacterium that have been never reported as able to utilize PCBs, thus deserving further investigation. The total removal of Aroclor 1242 and selected PCB congeners was evaluated at 4 and 15°C for eight bphA-harboring isolates and Gelidibacter sp. DS-10. With few exceptions, tested strains showed greater efficiency at 15 than at 4°C. Isolates were able to reduce most chromatographic peaks by >50%, with some di- and trichlorobiphenyls that were quite totally removed (>90%).
[Mh] Termos MeSH primário: Arocloros/análise
Bactérias Aeróbias/isolamento & purificação
Sedimentos Geológicos/microbiologia
Bifenilos Policlorados/análise
Água do Mar/microbiologia
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Aerobiose
Regiões Árticas
Arocloros/metabolismo
Bactérias Aeróbias/genética
Bactérias Aeróbias/metabolismo
Biodegradação Ambiental
Temperatura Baixa
Estuários
Sedimentos Geológicos/química
Bifenilos Policlorados/metabolismo
Água do Mar/química
Svalbard
Microbiologia da Água
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Water Pollutants, Chemical); 53469-21-9 (aroclor 1242); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


  5 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27794483
[Au] Autor:Gillette R; Reilly MP; Topper VY; Thompson LM; Crews D; Gore AC
[Ad] Endereço:Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, United States.
[Ti] Título:Anxiety-like behaviors in adulthood are altered in male but not female rats exposed to low dosages of polychlorinated biphenyls in utero.
[So] Source:Horm Behav;87:8-15, 2017 Jan.
[Is] ISSN:1095-6867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to polychlorinated biphenyls (PCBs), a class of endocrine-disrupting chemicals, can result in altered reproductive behavior in adulthood, especially when exposure occurs during critical periods of brain sexual differentiation in the fetus. Whether PCBs alter other sexually dimorphic behaviors such as those involved in anxiety is poorly understood. To address this, pregnant rat dams were injected twice, on gestational days 16 and 18, with the weakly estrogenic PCB mixture Aroclor 1221 (A1221) at one of two low dosages (0.5mg/kg or 1.0mg/kg, hereafter 1.0 and 0.5), estradiol benzoate (EB; 50µg/kg) as a positive estrogenic control, or the vehicle (3% DMSO in sesame oil). We also conducted a comprehensive assessment of developmental milestones of the F1 male and female offspring. There were no effects of treatment on sex ratio at birth and age at eye opening. Puberty, assessed by vaginal opening in females and preputial separation in males, was not affected in females but was advanced in males treated with A1221 (1.0). Males and females treated with A1221 (both dosages) were heavier in early adulthood relative to controls. The earliest manifestation of this effect developed in males prior to puberty and in females slightly later, during puberty. Anxiety-like behaviors were tested using the light:dark box and elevated plus maze tests in adulthood. In females, anxiety behaviors were unaffected by treatment. Males treated with A1221 (1.0) showed reduced indices of anxiety and increased activity in the light:dark box but not the elevated plus maze. EB failed to replicate the phenotype produced by A1221 for any of the developmental and behavioral endpoints. Collectively, these results indicate that PCBs increase body weight in both sexes, but their effects on anxiety-like behaviors are specific to males. Furthermore, differences between the results of A1221 and EB suggest that the PCBs are likely acting through mechanisms distinct from their estrogenic activity.
[Mh] Termos MeSH primário: Ansiedade/induzido quimicamente
Disruptores Endócrinos/toxicidade
Bifenilos Policlorados/toxicidade
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Efeitos Tardios da Exposição Pré-Natal/psicologia
[Mh] Termos MeSH secundário: Animais
Arocloros/administração & dosagem
Arocloros/toxicidade
Relação Dose-Resposta a Droga
Disruptores Endócrinos/administração & dosagem
Estradiol/análogos & derivados
Estradiol/farmacologia
Feminino
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Bifenilos Policlorados/administração & dosagem
Gravidez
Ratos
Ratos Sprague-Dawley
Reprodução/efeitos dos fármacos
Caracteres Sexuais
Diferenciação Sexual/efeitos dos fármacos
Maturidade Sexual/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Endocrine Disruptors); 11104-28-2 (aroclor 1221); 1S4CJB5ZGN (estradiol 3-benzoate); 4TI98Z838E (Estradiol); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  6 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27734310
[Au] Autor:Tekin S; Pazi I
[Ad] Endereço:Centre For Drug Research and Development and Pharmacokinetic Applications (ARGEFAR), Ege University, Bornova, 35100, Izmir, Turkey.
[Ti] Título:POP levels in blue crab (Callinectes sapidus) and edible fish from the eastern Mediterranean coast.
[So] Source:Environ Sci Pollut Res Int;24(1):509-518, 2017 Jan.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Organochlorinated pesticides and Aroclors were measured in the muscle of two edible fish species (gray mullet, sea bream) and blue crab, collected from eastern Mediterranean coast in 2013. The concentration of organochlorinated pesticides (OCPs) and Aroclors in biota samples which were collected at six sites ranged from 1.0-8.6 and 9-47.5 ng g wet weight, respectively. Total DDT concentrations in seafood samples were compared to tolerance level established by the US Food and Drug Administration (FDA); the concentrations were detected below the tolerence level. Health risk assessment was conducted related to the consumption of chemically contaminated seafood. The estimated daily intake of OCPs calculated by using the estimated daily fish consumption in Turkey was far below the acceptable daily intake as established by FAO/WHO. Our data indicated that consumption of blue crab, gray mullet, and sea bream collected from the Mediterranean coast of Turkey could pose "no risk" for human health in terms of OCPs.
[Mh] Termos MeSH primário: Braquiúros/metabolismo
Exposição Ambiental
Hidrocarbonetos Clorados/metabolismo
Dourada/metabolismo
Alimentos Marinhos/análise
Smegmamorpha/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Animais
Arocloros/metabolismo
Monitoramento Ambiental
Mar Mediterrâneo
Músculos/química
Praguicidas/metabolismo
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Hydrocarbons, Chlorinated); 0 (Pesticides); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7661-6


  7 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27581792
[Au] Autor:Aly HA; Alahdal AM; Nagy AA; Abdallah HM; Abdel-Sattar EA; Azhar AS
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
[Ti] Título:Lipoic acid and Calligonum comosumon attenuate aroclor 1260-induced testicular toxicity in adult rats.
[So] Source:Environ Toxicol;32(4):1147-1157, 2017 Apr.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aroclor 1260 is one of the more representative polychlorinated biphenyls found in biota. This study was designed to delineate the testicular toxicity of Aroclor 1260 and to elucidate the potential protective role of Calligonum comosum (C. comosum) and lipoic acid in adult rats. Aroclor 1260 was dissolved in corn oil and given to rats by gavage at doses 0, 20, 40, or 60 mg/kg/day for 15 consecutive days (Groups I, II, III, and IV, respectively). Groups V and VI were pretreated with C. comosum (200 mg/kg/day) and lipoic acid (35 mg/kg/day) respectively 24 h before Aroclor 1260 (40 mg/kg/day) treatment for 15 consecutive days. Aroclor 1260 (20, 40 or 60 mg/kg/day) treatment significantly decreased testes weight, sperm count and motility and daily sperm production. Serum testosterone was significantly decreased in response to treatment with 40 and 60 mg/kg/day of Aroclor 1260. LDH-X activity was significantly decreased at the three dose levels. Hydrogen peroxide (H O ) production (in a dose-related manner) and lipid peroxidation were significantly increased in response to Aroclor 1260 (20, 40, or 60 mg/kg/day) treatment. Aroclor 1260 at the three dose levels decreased the activities of the antioxidant enzymes SOD, CAT, GPx, and GR and the non-enzymatic antioxidant GSH level. CAT, GPx and GSH showed a dose-response effect. These abnormalities were effectively attenuated by pretreatment with C. comosum (200 mg/kg/day) or lipoic acid (35 mg/kg/day). Histopathological examination showed a dose-related increase in morphological abnormalities of the testis in response to Aroclor 1260 treatment. In conclusion, Aroclor 1260 induced testicular toxicity at least, in part, by induction of oxidative stress. By reversal of biochemical and morphological changes towards normalcy, the cytoprotective role of C. comosum and lipoic acid is illuminated. In comparison, lipoic acid was more protective than C. comosum extract against testicular toxicity induced by Aroclor 1260. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1147-1157, 2017.
[Mh] Termos MeSH primário: Arocloros/toxicidade
Poluentes Ambientais/toxicidade
Depuradores de Radicais Livres/farmacologia
Extratos Vegetais/farmacologia
Testículo/efeitos dos fármacos
Ácido Tióctico/farmacologia
[Mh] Termos MeSH secundário: Animais
Citoproteção
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Estresse Oxidativo/efeitos dos fármacos
Polygonaceae/química
Ratos
Ratos Wistar
Contagem de Espermatozoides
Testículo/enzimologia
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Environmental Pollutants); 0 (Free Radical Scavengers); 0 (Plant Extracts); 11096-82-5 (aroclor 1260); 73Y7P0K73Y (Thioctic Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22310


  8 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27917541
[Au] Autor:Garcia MS; Constantino DH; Silva AP; Perobelli JE
[Ad] Endereço:Central de Laboratórios de Ciência e Tecnologia Ambiental, Universidade Sagrado Coração, USC, Bauru, São Paulo, Brazil.
[Ti] Título:Fish pollutants MeHg and Aroclor cause permanent structural damage in male gonads and kidneys after prepubertal exposure.
[So] Source:Int J Exp Pathol;97(5):360-368, 2016 10.
[Is] ISSN:1365-2613
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated whether or not prepubertal exposure to the fish contaminants methylmercury (MeHg) and the polychlorinated bisphenol Aroclor in low doses interferes with the histomorphometry of the testes, epididymis, liver and kidneys in rats. Wistar male rats, 21 days old, were allocated into the following: control (n = 17, received corn oil), MeHg (n = 17, received MeHg at 0.5 mg/kg/day), Aroclor (n = 17, received Aroclor at 1.0 mg/kg/day), low mix (n = 18, received MeHg at 0.05 mg/kg/day and Aroclor at 0.1 mg/kg/day), high mix (n = 18, received MeHg at 0.5 mg/kg/day and Aroclor at 1.0 mg/kg/day). Dosing continued from post natal day (PND) 23 to 53, by gavage. Euthanasia was performed on PND 53; or, after an interval of 62 days without exposure to chemicals, on PND 115. The degree of maturation of the seminiferous epithelium was delayed in chemical-exposed groups and testicular interstitial oedema was observed at adulthood. The pattern of male gonad organization was changed in the Aroclor group on PND 53 and in all treated groups at adulthood. The animals from Aroclor, low mix and high mix groups showed a reduction in the number of Sertoli cells. Histological evidence of renal injury was observed in all chemical-exposed groups in both ages. A probable target for MeHg and Aroclor in the reproductive system was Sertoli cells, in which possible dysfunctions could be linked to the other testicular alterations. Curiously, the main deleterious effects were late outcomes, along with the absence of synergistic interaction of MeHg and Aroclor in the parameters investigated. In conclusion, fish pollutants MeHg and Aroclor caused permanent structural damage in male gonads and kidneys after prepubertal exposure, without showing clear chemical interactions.
[Mh] Termos MeSH primário: Arocloros/toxicidade
Peixes/metabolismo
Contaminação de Alimentos
Rim/efeitos dos fármacos
Compostos de Metilmercúrio/toxicidade
Testículo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Biometria/métodos
Poluentes Ambientais/toxicidade
Feminino
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/patologia
Masculino
Puberdade
Ratos Wistar
Túbulos Seminíferos/efeitos dos fármacos
Túbulos Seminíferos/patologia
Espermatogênese/efeitos dos fármacos
Testículo/patologia
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aroclors); 0 (Environmental Pollutants); 0 (Methylmercury Compounds)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.1111/iep.12200


  9 / 1150 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26946220
[Au] Autor:Yauk CL; Buick JK; Williams A; Swartz CD; Recio L; Li HH; Fornace AJ; Thomson EM; Aubrecht J
[Ad] Endereço:Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.
[Ti] Título:Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9.
[So] Source:Environ Mol Mutagen;57(4):243-60, 2016 May.
[Is] ISSN:1098-2280
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not express cytochrome P450s, we confirmed accurate classification by the biomarker in cells co-exposed to 1% 5,6 benzoflavone/phenobarbital-induced rat liver S9 for metabolic activation. However, chemicals may require different types of S9 for activation. Here we investigated the response of TK6 cells to higher percentages of Aroclor-, benzoflavone/phenobarbital-, or ethanol-induced rat liver S9 to expand TGx-28.65 biomarker applicability. Transcriptional profiles were derived 3 to 4 hr following a 4 hr co-exposure of TK6 cells to test chemicals and S9. Preliminary studies established that 10% Aroclor- and 5% ethanol-induced S9 alone did not induce the TGx-28.65 biomarker genes. Seven genotoxic and two non-genotoxic chemicals (and concurrent solvent and positive controls) were then tested with one of the S9s (selected based on cell survival and micronucleus induction). Relative survival and micronucleus frequency was assessed by flow cytometry in cells 20 hr post-exposure. Genotoxic/non-genotoxic chemicals were accurately classified using the different S9s. One technical replicate of cells co-treated with dexamethasone and 10% Aroclor-induced S9 was falsely classified as genotoxic, suggesting caution in using high S9 concentrations. Even low concentrations of genotoxic chemicals (those not causing cytotoxicity) were correctly classified, demonstrating that TGx-28.65 is a sensitive biomarker of genotoxicity. A meta-analysis of datasets from 13 chemicals supports that different S9s can be used in TK6 cells, without impairing classification using the TGx-28.65 biomarker.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica/métodos
Testes de Mutagenicidade/métodos
Mutagênicos/toxicidade
[Mh] Termos MeSH secundário: Ativação Metabólica/efeitos dos fármacos
Animais
Apoptose/efeitos dos fármacos
Arocloros/toxicidade
Benzoflavonas/toxicidade
Linhagem Celular
Etanol/toxicidade
Marcadores Genéticos
Seres Humanos
Fígado/efeitos dos fármacos
Fenobarbital/toxicidade
Ratos
Transcriptoma/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aroclors); 0 (Benzoflavones); 0 (Genetic Markers); 0 (Mutagens); 3K9958V90M (Ethanol); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160307
[St] Status:MEDLINE
[do] DOI:10.1002/em.22004


  10 / 1150 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26814625
[Au] Autor:Fuchsman PC; Henning MH; Magar VS
[Ad] Endereço:Ramboll Environ, 13801 West Center Street, Burton, Ohio, USA. pfuchsman@ramboll.com.
[Ti] Título:Comment on "Exposure to mercury and Aroclor 1268 congeners in least terns (Sternula antillarum) in coastal Georgia, USA" by G. L. Robinson, G. L. Mills, A. H. Lindell, S. H. Schweitzer and S. M. Hernandez, Environmental Science: Processes & Impacts, 2015, 17, 1424.
[So] Source:Environ Sci Process Impacts;18(2):289-91; discussion 292-3, 2016 Feb.
[Is] ISSN:2050-7895
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In a recent paper published in this journal (Robinson et al., Environmental Science: Processes & Impacts, 2015, 17, 1424), Robinson et al. reported concentrations of Aroclor 1268 congeners in least tern eggs in coastal Georgia, USA. This comment describes important omissions in Robinson et al.'s interpretation of those egg concentrations that alter the overall conclusions of the least tern study.
[Mh] Termos MeSH primário: Arocloros/metabolismo
Charadriiformes/metabolismo
Monitoramento Ambiental
Mercúrio/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Water Pollutants, Chemical); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160218
[Lr] Data última revisão:
160218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160128
[St] Status:MEDLINE
[do] DOI:10.1039/c5em00489f



página 1 de 115 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde