Base de dados : MEDLINE
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[PMID]:29291440
[Au] Autor:Vágvölgyi M; Martins A; Kulmány Á; Zupkó I; Gáti T; Simon A; Tóth G; Hunyadi A
[Ad] Endereço:Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
[Ti] Título:Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam.
[So] Source:Eur J Med Chem;144:730-739, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Multidrug resistance is a widespread problem among various diseases and cancer is no exception. We had previously described the chemo-sensitizing activity of ecdysteroid derivatives with low polarity on drug susceptible and multi-drug resistant (MDR) cancer cells. We have also shown that these molecules have a marked selectivity towards the MDR cells. Recent studies on the oximation of various steroid derivatives indicated remarkable increase in their antitumor activity, but there is no related bioactivity data on ecdysteroid oximes. In our present study, 13 novel ecdysteroid derivatives (oximes, oxime ethers and a lactam) and one known compound were synthesized from 20-hydroxyecdysone 2,3;20,22-diacetonide and fully characterized by comprehensive NMR techniques revealing their complete H and C signal assignments. The compounds exerted moderate to strong in vitro antiproliferative activity on HeLa, SiHa, MCF-7 and MDA-MB-231 cell lines. Oxime and particularly oxime ether formation strongly increased their inhibitory activity on the efflux of rhodamine 123 by P-glycoprotein (P-gp), while the new ecdysteroid lactam did not interfere with the efflux function. All compounds exerted potent chemo-sensitizing activity towards doxorubicin on a mouse lymphoma cell line and on its MDR counterpart, and, on the latter, the lactam was found the most active. Because of its MDR-selective chemo-sensitizing activity with no functional effect on P-gp, this lactam is of high potential interest as a new lead for further antitumor studies.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Ecdisteroides/farmacologia
Éteres/farmacologia
Lactamas/farmacologia
Neoplasias/tratamento farmacológico
Nitrogênio/farmacologia
Oximas/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Resistência a Múltiplos Medicamentos/efeitos dos fármacos
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Ecdisteroides/síntese química
Ecdisteroides/química
Éteres/síntese química
Éteres/química
Seres Humanos
Lactamas/síntese química
Lactamas/química
Estrutura Molecular
Neoplasias/patologia
Nitrogênio/química
Oximas/síntese química
Oximas/química
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Ecdysteroids); 0 (Ethers); 0 (Lactams); 0 (Oximes); N762921K75 (Nitrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:29205213
[Au] Autor:Zanelli L; Todros S; Carniel EL; Pavan PG; Pavan PG
[Ad] Endereço:Department of Mathematics, University of Padova, Padova, Italy.
[Ti] Título:Mechanical properties variation and constitutive modelling of biomedical polymers after sterilization.
[So] Source:Acta Bioeng Biomech;19(3):3-9, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In this work, the mechanical behavior of two block copolymers for biomedical applications is studied with particular regard to the effects induced by a steam sterilization treatment that biomedical devices usually undergo in healthcare facilities. This investigation is aimed at describing the elasto-plastic behavior of the stress-strain response, determining a functional dependence between material constitutive parameters, to obtain an optimal constitutive model. METHODS: The mechanical properties of these polymers are analyzed through uniaxial tensile tests, before and after the sterilization process. The effect of sterilization on the mechanical behavior is evaluated. The Ramberg-Osgood model is used to describe the elasto-plastic behavior of the stress-strain response. RESULTS: Data from uniaxial tensile tests are discussed in the light of previous data on the same polymeric materials, in order to highlight the correlation between physicochemical and mechanical properties variation. The material constitutive parameters are determined and the functional dependence between them is found, thus enabling an optimal constitutive model to be obtained. CONCLUSIONS: The effect of sterilization on the material constitutive parameters is studied, to evaluate the suitability of the model in describing the mechanical response of biomedical polymer before and after sterilization treatment. The same approach can be applied to other biomaterials, under various tensile tests, and for several processes that induce variation in mechanical properties.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Éteres/química
Modelos Químicos
Nylons/química
Esterilização/métodos
[Mh] Termos MeSH secundário: Força Compressiva
Simulação por Computador
Módulo de Elasticidade
Teste de Materiais
Estresse Mecânico
Resistência à Tração
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Ethers); 0 (Nylons); 0 (polyamide-ether-elastomer)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:28917650
[Au] Autor:Belmessieri D; Gozlan C; Duclos MC; Dumitrescu O; Lina G; Redl A; Duguet N; Lemaire M
[Ad] Endereço:Univ Lyon, Université Claude Bernard Lyon1, CNRS, INSA-Lyon, CPE-Lyon, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, (ICBMS), UMR 5246, Equipe CAtalyse, SYnthèse et ENvironnement (CASYEN), 43 boulevard du 11 novembre 1918, F-69622 Villeurbanne Cedex, France; Univ Lyon, Universit
[Ti] Título:Dodecyl sorbitan ethers as antimicrobials against Gram-positive bacteria.
[So] Source:Bioorg Med Chem Lett;27(20):4660-4663, 2017 10 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A range of amphiphilic sorbitan ethers has been synthesized in two steps from sorbitan following an acetalization/hydrogenolysis sequence. These sorbitan ethers and the acetal intermediates have been evaluated as antimicrobials against Gram-negative and Gram-positive bacteria. No antimicrobial activity was observed for Gram-negative bacteria. However, the compounds bearing a linear dodecyl chain exhibit antimicrobial activity (MIC as low as 8µg/mL) against Gram-positive bacteria such as Listeria monocytogenes, Enterococcus faecalis and Staphylococcus aureus. Encouraged by these preliminary results, dodecyl sorbitan was tested against a range of resistant strains and was found to be active against vancomycin-, methicillin- and daptomycin-resistant strains (MIC=32-64µg/mL).
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Éteres/química
Éteres/farmacologia
Bactérias Gram-Positivas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anti-Infecciosos/síntese química
Farmacorresistência Bacteriana/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Polissorbatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Ethers); 0 (Polysorbates)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


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[PMID]:28868763
[Au] Autor:Shinde S; Rode C
[Ad] Endereço:Chemical Engineering and Process Development Division, CSIR National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
[Ti] Título:Cascade Reductive Etherification of Bioderived Aldehydes over Zr-Based Catalysts.
[So] Source:ChemSusChem;10(20):4090-4101, 2017 Oct 23.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:An efficient one-pot catalytic cascade sequence has been developed for the production of value-added ethers from bioderived aldehydes. Etherification of 5-(hydroxymethyl)furfural with different aliphatic alcohols over acidic Zr-montmorillonite (Zr-Mont) catalyst produced a mixture of 5-(alkoxymethyl)furfural and 2-(dialkoxymethyl)-5-(alkoxymethyl)furan. The latter was selectively converted back into 5-(alkoxymethyl)furfural by treating it with water over the same catalyst. The synthesis of 2,5-bis(alkoxymethyl)furan was achieved through a cascade sequence involving etherification, transfer hydrogenation, and re-etherification over a combination of acidic Zr-Mont and the charge-transfer hydrogenation catalyst [ZrO(OH) ]. This catalyst combination was further explored for the cascade conversion of 2-furfuraldehyde into 2-(alkoxymethyl)furan. The scope of this strategy was then extended for the reductive etherification of lignin-derived arylaldehydes to obtain the respective benzyl ethers in >80 % yield. Additionally, the mixture of Zr-Mont and ZrO(OH) does not undergo mutual destruction, which was proved by recycling experiments and XRD analysis. Both the catalysts were thoroughly characterized using BET, temperature-programmed desorption of NH and CO , pyridine-FTIR, XRD, inductively coupled plasma optical emission spectroscopy, and X-ray photoelectron spectroscopy techniques.
[Mh] Termos MeSH primário: Aldeídos/química
Éteres/química
Zircônio/química
[Mh] Termos MeSH secundário: 2-Propanol/química
Catálise
Furaldeído/análogos & derivados
Furaldeído/química
Hidrogenação
Modelos Moleculares
Conformação Molecular
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Ethers); 70ETD81LF0 (5-hydroxymethylfurfural); C6V6S92N3C (Zirconium); DJ1HGI319P (Furaldehyde); ND2M416302 (2-Propanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701275


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[PMID]:28844931
[Au] Autor:Zhang C; Liu SJ; Yang L; Yuan MY; Li JY; Hou B; Li HM; Yang XZ; Ding CC; Hu JM
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, People's Republic of China.
[Ti] Título:Sesquiterpene amino ether and cytotoxic phenols from Dendrobium wardianum Warner.
[So] Source:Fitoterapia;122:76-79, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A new bibenzyl derivative, dendrocandin V (1) and a new sesquiterpene amino ether, wardianumine A (2), together with eleven known compounds, including phenanthrenes (denbinobin (3), 9,10-dihydro-denbinobin (4), mostatin (5), loddigesiinols A (6)), bibenzyls (moscatilin (7), 5-hydroxy-3,4'-dimethoxybibenzyl (8), 3,4-dihydroxy-5,4'-dimethoxy bibenzyl (9), dendrocandin A (10), gigantol (11), dendrocandin U (12)) and an alkaloids (dihydroshihunine, 13) were isolated from the EtOH extraction of stems of Dendrobium wardianum Warner. Isolation of the new compound 2 indicated that N,N-dimethylethanolamine as the key adduction in the synthesis of dendroxine and its analogs in Dendrobium species. The hypothetical biosynthetic pathway of 2 was then postulated. Inspired by literature and traditional usage of the herbal medicine, some compounds were sent for cytotoxic activity and the results indicated that compounds 1, 3, 4, 5 showed cytotoxic activities against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC50 from 2.33-38.48µM. Among those compounds, 3 and 4 showed cell line selectivity with strong activity comparable to DDP.
[Mh] Termos MeSH primário: Dendrobium/química
Éteres/química
Fenóis/química
Sesquiterpenos/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Éteres/isolamento & purificação
Seres Humanos
Estrutura Molecular
Fenóis/isolamento & purificação
Caules de Planta/química
Plantas Medicinais/química
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Ethers); 0 (Phenols); 0 (Sesquiterpenes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28832632
[Au] Autor:Song J; Kang HJ; Lee JW; Wenas MA; Jeong SH; Lee T; Oh K; Min KH
[Ad] Endereço:College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
[Ti] Título:Transetherification of 2,4-dimethoxynitrobenzene by aromatic nucleophilic substitution.
[So] Source:PLoS One;12(8):e0183575, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In view of the few reports concerning aromatic nucleophilic substitution reactions featuring an alkoxy group as a leaving group, the aromatic nucleophilic substitution of 2,4-dimethoxynitrobenzene was investigated with a bulky t-butoxide nucleophile under microwave irradiation. The transetherification of 2,4-dimethoxynitrobenezene with sodium t-butoxide under specific conditions, namely for 20 min at 110°C in 10% dimethoxyethane in toluene, afforded the desired product in 87% yield with exclusive ortho-selectivity. A variety of reaction conditions were screened to obtain the maximum yield. The aromatic nucleophilic substitution of 2,4-dimethoxynitrobenzene with t-butoxide should be carried out under controlled conditions in order to avoid the formation of byproducts, unlike that of dihalogenated activated benzenes. Among the formed byproducts, a major compound was elucidated as 2,4-dimethoxy-N-(5-methoxy-2-nitrophenyl)aniline by X-ray crystallography.
[Mh] Termos MeSH primário: Éteres/química
Nitrobenzenos/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
Cristalografia por Raios X
Espectroscopia de Prótons por Ressonância Magnética
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethers); 0 (Nitrobenzenes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183575


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[PMID]:28779679
[Au] Autor:Lai C; Tang S; Yang B; Gao Z; Li X; Yong Q
[Ad] Endereço:Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China; College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
[Ti] Título:Enhanced enzymatic saccharification of corn stover by in situ modification of lignin with poly (ethylene glycol) ether during low temperature alkali pretreatment.
[So] Source:Bioresour Technol;244(Pt 1):92-99, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel pretreatment process of corn stover was established in this study by in situ modification of lignin with poly (ethylene glycol) diglycidyl ether (PEGDE) during low temperature alkali pretreatment. The addition of PEGDE obviously improved the enzymatic hydrolysis by covalently modifying the residual lignins in substrates. Under the optimized conditions (pretreated with 10% (w/w) NaOH and 10% (w/w) PEGDE at 70°C for 2.5h), the total fermentable sugar yield was increased by 46.4%, from 23.7g to 34.7g per 100g raw materials. Additionally, the remaining activities of exo-glucanase and ß-glucosidase in supernatant were increased by 58.6% and 40.6% respectively, demonstrating that the enhancement of enzymatic hydrolysis was mainly due to the alleviation of enzyme non-productive binding. Although the isolated lignin modified with PEGDE enhanced the enzymatic hydrolysis of substrates as well, this in situ lignin modification provided an efficient but simple way to improve enzymatic saccharification.
[Mh] Termos MeSH primário: Etilenoglicóis
Lignina
Zea mays
[Mh] Termos MeSH secundário: Álcalis
Éteres
Hidrólise
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkalies); 0 (Ethers); 0 (Ethylene Glycols); 9005-53-2 (Lignin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


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[PMID]:28730737
[Au] Autor:Teong SP; Lim J; Zhang Y
[Ad] Endereço:Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.
[Ti] Título:Vinylation of Aryl Ether (Lignin ß-O-4 Linkage) and Epoxides with Calcium Carbide through C-O Bond Cleavage.
[So] Source:ChemSusChem;10(16):3198-3201, 2017 Aug 24.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Calcium carbide has been increasingly used as a sustainable, easy-to-handle, and low-cost feedstock in organic synthesis. Currently, methodologies of using calcium carbide as "solid acetylene" in synthesis are strictly limited to activation and reaction with X-H (X=C, N, O, S) bonds. Herein, a mild and transition-metal-free protocol was developed for the vinylation of epoxides and aryl ether linkage (ß-O-4 lignin model compound) with calcium carbide through C-O bond cleavage, forming valuable vinyl ether products. Calcium carbide plays a vital role in the C-O bond activation and cleavage, and in providing acetylide source for the formation of vinylated products. These exciting results may provide new methodologies for organic synthesis and new insights toward lignin- or biomassrelated degradation to useful products.
[Mh] Termos MeSH primário: Acetileno/análogos & derivados
Alcenos/química
Carbono/química
Compostos de Epóxi/química
Éteres/química
Lignina/química
Oxigênio/química
[Mh] Termos MeSH secundário: Acetileno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Epoxy Compounds); 0 (Ethers); 7440-44-0 (Carbon); 846WNV4A5F (calcium carbide); 9005-53-2 (Lignin); OC7TV75O83 (Acetylene); S88TT14065 (Oxygen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701153


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[PMID]:28708379
[Au] Autor:Wyche TP; Alvarenga RFR; Piotrowski JS; Duster MN; Warrack SR; Cornilescu G; De Wolfe TJ; Hou Y; Braun DR; Ellis GA; Simpkins SW; Nelson J; Myers CL; Steele J; Mori H; Safdar N; Markley JL; Rajski SR; Bugni TS
[Ad] Endereço:Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
[Ti] Título:Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.
[So] Source:ACS Chem Biol;12(9):2287-2295, 2017 Sep 15.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A polyether antibiotic, ecteinamycin (1), was isolated from a marine Actinomadura sp., cultivated from the ascidian Ecteinascidia turbinata. C enrichment, high resolution NMR spectroscopy, and molecular modeling enabled elucidation of the structure of 1, which was validated on the basis of comparisons with its recently reported crystal structure. Importantly, ecteinamycin demonstrated potent activity against the toxigenic strain of Clostridium difficile NAP1/B1/027 (MIC = 59 ng/µL), as well as other toxigenic and nontoxigenic C. difficile isolates both in vitro and in vivo. Additionally, chemical genomics studies using Escherichia coli barcoded deletion mutants led to the identification of sensitive mutants such as trkA and kdpD involved in potassium cation transport and homeostasis supporting a mechanistic proposal that ecteinamycin acts as an ionophore antibiotic. This is the first antibacterial agent whose mechanism of action has been studied using E. coli chemical genomics. On the basis of these data, we propose ecteinamycin as an ionophore antibiotic that causes C. difficile detoxification and cell death via potassium transport dysregulation.
[Mh] Termos MeSH primário: Actinomycetales/química
Antibacterianos/química
Antibacterianos/farmacologia
Clostridium difficile/efeitos dos fármacos
Ionóforos/química
Ionóforos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/isolamento & purificação
Enterocolite Pseudomembranosa/tratamento farmacológico
Enterocolite Pseudomembranosa/microbiologia
Éteres/química
Éteres/isolamento & purificação
Éteres/farmacologia
Seres Humanos
Ionóforos/isolamento & purificação
Urocordados/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Ethers); 0 (Ionophores)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.7b00388


  10 / 7762 MEDLINE  
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[PMID]:28699190
[Au] Autor:Steinbauer J; Werner T
[Ad] Endereço:Leibniz Institute for Catalysis at the, University of Rostock (LIKAT), Albert Einstein Str. 29a, 18059, Rostock, Germany.
[Ti] Título:Poly(ethylene glycol)s as Ligands in Calcium-Catalyzed Cyclic Carbonate Synthesis.
[So] Source:ChemSusChem;10(15):3025-3029, 2017 Aug 10.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Herein the use of CaI in combination with poly(ethylene glycol) dimethyl ether (PEG DME 500) as an efficient catalyst system for the addition of CO to epoxides is reported. This protocol is based on a nontoxic and abundant metal in conjunction with a polymeric ligand. Fifteen terminal epoxides were converted at room temperature to give the desired products in yields up to 99 %. Notably, this system was also effective for the synthesis of twelve challenging internal carbonates in yields up to 98 %.
[Mh] Termos MeSH primário: Cálcio/química
Carbonatos/química
Carbonatos/síntese química
Éteres/química
Polietilenoglicóis/química
[Mh] Termos MeSH secundário: Catálise
Técnicas de Química Sintética
Ligantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbonates); 0 (Ethers); 0 (Ligands); 0 (poly(ethylene glycol) dimethyl ether); 30IQX730WE (Polyethylene Glycols); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700788



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